| Reaction Details |
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 | Report a problem with these data |
| Target | Dopamine beta-hydroxylase |
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| Ligand | BDBM50014968 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_59269 (CHEMBL872495) |
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| pH | 6.6±n/a |
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| Ki | 344±n/a nM |
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| Comments | extracted |
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| Citation |  Kruse, LI; Kaiser, C; DeWolf, WE; Frazee, JS; Garvey, E; Hilbert, EL; Faulkner, WA; Flaim, KE; Sawyer, JL; Berkowitz, BA Multisubstrate inhibitors of dopamine beta-hydroxylase. 1. Some 1-phenyl and 1-phenyl-bridged derivatives of imidazole-2-thione. J Med Chem29:2465-72 (1987) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Dopamine beta-hydroxylase |
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| Name: | Dopamine beta-hydroxylase |
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| Synonyms: | DBH | DOPO_BOVIN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 68136.39 |
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| Organism: | Bos taurus |
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| Description: | ChEMBL_50738 |
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| Residue: | 610 |
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| Sequence: | MQVPSPSVREAASMYGTAVAVFLVILVAALQGSAPAESPFPFHIPLDPEGTLELSWNISY
AQETIYFQLLVRELKAGVLFGMSDRGELENADLVVLWTDRDGAYFGDAWSDQKGQVHLDS
QQDYQLLRAQRTPEGLYLLFKRPFGTCDPNDYLIEDGTVHLVYGFLEEPLRSLESINTSG
LHTGLQRVQLLKPSIPKPALPADTRTMEIRAPDVLIPGQQTTYWCYVTELPDGFPRHHIV
MYEPIVTEGNEALVHHMEVFQCAAEFETIPHFSGPCDSKMKPQRLNFCRHVLAAWALGAK
AFYYPEEAGLAFGGPGSSRFLRLEVHYHNPLVITGRRDSSGIRLYYTAALRRFDAGIMEL
GLAYTPVMAIPPQETAFVLTGYCTDKCTQLALPASGIHIFASQLHTHLTGRKVVTVLARD
GRETEIVNRDNHYSPHFQEIRMLKKVVSVQPGDVLITSCTYNTEDRRLATVGGFGILEEM
CVNYVHYYPQTQLELCKSAVDPGFLHKYFRLVNRFNSEEVCTCPQASVPEQFASVPWNSF
NREVLKALYGFAPISMHCNRSSAVRFQGEWNRQPLPEIVSRLEEPTPHCPASQAQSPAGP
TVLNISGGKG
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|
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| BDBM50014968 |
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| n/a |
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| Name | BDBM50014968 |
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| Synonyms: | 1-(4-Hydroxy-benzyl)-1,3-dihydro-imidazole-2-thione | 4-(2-Mercapto-imidazol-1-ylmethyl)-phenol | CHEMBL164747 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H10N2OS |
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| Mol. Mass. | 206.264 |
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| SMILES | Oc1ccc(Cn2cc[nH]c2=S)cc1 |
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| Structure | 
|
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