BindingDB PrimarySearch

Found 11 hits Enz. Inhib. hit(s) with Target = 'Indoleamine 2,3-dioxygenase 1' and Ligand = 'BDBM50126142'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM50126142 (4-Phenylimidazole \| CHEMBL14145 \| US11053207, Comp...) Show SMILES c1ncc([nH]1)-c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
SIB Swiss Institute of Bioinformatics Curated by ChEMBL					Assay Description Inhibition of full-length human IDO1 expressed in Escherichia coli Rosetta (DE3) using L-Trp substrate by HPLC analysis				J Med Chem 62: 8784-8795 (2019) Article DOI: 10.1021/acs.jmedchem.9b00942 BindingDB Entry DOI: 10.7270/Q22V2KK8
SIB Swiss Institute of Bioinformatics Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM50126142 (4-Phenylimidazole \| CHEMBL14145 \| US11053207, Comp...) Show SMILES c1ncc([nH]1)-c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
SIB Swiss Institute of Bioinformatics Curated by ChEMBL					Assay Description Inhibition of full-length human IDO1 expressed in Escherichia coli Rosetta (DE3) using L-Trp substrate by HPLC analysis				J Med Chem 62: 8784-8795 (2019) Article DOI: 10.1021/acs.jmedchem.9b00942 BindingDB Entry DOI: 10.7270/Q22V2KK8
SIB Swiss Institute of Bioinformatics Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM50126142 (4-Phenylimidazole \| CHEMBL14145 \| US11053207, Comp...) Show SMILES c1ncc([nH]1)-c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	2.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human IDO1 expressed in Escherichia coli Rosetta (DE3) cells assessed as reduction in kynurenine production using L-tryptop...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01968 BindingDB Entry DOI: 10.7270/Q2G164NR
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM50126142 (4-Phenylimidazole \| CHEMBL14145 \| US11053207, Comp...) Show SMILES c1ncc([nH]1)-c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	2.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
NewLink Genetics Corporation Curated by ChEMBL					Assay Description Inhibition of purified human IDO1 using L-tryptophan as substrate preincubated for 5 mins followed by substrate addition and measured after 15 mins b...				J Med Chem 62: 6705-6733 (2019) Article DOI: 10.1021/acs.jmedchem.9b00662 BindingDB Entry DOI: 10.7270/Q21G0QNZ
NewLink Genetics Corporation Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM50126142 (4-Phenylimidazole \| CHEMBL14145 \| US11053207, Comp...) Show SMILES c1ncc([nH]1)-c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB US Patent	n/a	n/a	3.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Firstly, the compound was subject to a 3-fold gradient dilution. 1 μL of each concentration was added to a 96-well plate; 50 μL of the IDO ...				Citation and Details BindingDB Entry DOI: 10.7270/Q289191R
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM50126142 (4-Phenylimidazole \| CHEMBL14145 \| US11053207, Comp...) Show SMILES c1ncc([nH]1)-c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	4.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
School of Pharmacy, Fudan University, Shanghai 201203, China. Curated by ChEMBL					Assay Description Inhibition of human IDO expressed in Escherichia coli BL21(DE3) cells assessed as inhibition of kynurenine production using L-tryptophan as substrate...				Bioorg Med Chem 25: 3780-3791 (2017) Article DOI: 10.1016/j.bmc.2017.05.017 BindingDB Entry DOI: 10.7270/Q2QJ7KQR
					More data for this Ligand-Target Pair				3D Structure (crystal)
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM50126142 (4-Phenylimidazole \| CHEMBL14145 \| US11053207, Comp...) Show SMILES c1ncc([nH]1)-c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	4.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Colorado College Curated by ChEMBL					Assay Description Inhibition of IDO1 (unknown origin)				J Med Chem 58: 8762-82 (2015) Article DOI: 10.1021/acs.jmedchem.5b00461 BindingDB Entry DOI: 10.7270/Q2C82C3F
Colorado College Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM50126142 (4-Phenylimidazole \| CHEMBL14145 \| US11053207, Comp...) Show SMILES c1ncc([nH]1)-c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	4.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.ejmech.2021.113967 BindingDB Entry DOI: 10.7270/Q26W9G4F
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM50126142 (4-Phenylimidazole \| CHEMBL14145 \| US11053207, Comp...) Show SMILES c1ncc([nH]1)-c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	1.40E+5	n/a	n/a	n/a	n/a	n/a	n/a
SIB Swiss Institute of Bioinformatics Curated by ChEMBL					Assay Description Inhibition of IDO1 in IFN-gamma-stimulated human HeLa cells assessed as decrease in kynurenine levels after 48 hrs				J Med Chem 62: 8784-8795 (2019) Article DOI: 10.1021/acs.jmedchem.9b00942 BindingDB Entry DOI: 10.7270/Q22V2KK8
SIB Swiss Institute of Bioinformatics Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM50126142 (4-Phenylimidazole \| CHEMBL14145 \| US11053207, Comp...) Show SMILES c1ncc([nH]1)-c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	1.40E+5	n/a	n/a	n/a	n/a	n/a	n/a
SIB Swiss Institute of Bioinformatics Curated by ChEMBL					Assay Description Inhibition of IDO1 in IFN-gamma-stimulated human HeLa cells assessed as decrease in kynurenine levels after 48 hrs				J Med Chem 62: 8784-8795 (2019) Article DOI: 10.1021/acs.jmedchem.9b00942 BindingDB Entry DOI: 10.7270/Q22V2KK8
SIB Swiss Institute of Bioinformatics Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM50126142 (4-Phenylimidazole \| CHEMBL14145 \| US11053207, Comp...) Show SMILES c1ncc([nH]1)-c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	1.43E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human IDO1				Citation and Details BindingDB Entry DOI: 10.7270/Q21G0QZ0
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)