BindingDB PrimarySearch

Found 4 hits Enz. Inhib. hit(s) with Target = 'Macrophage metalloelastase' and Ligand = 'BDBM50215926'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Macrophage metalloelastase (Homo sapiens (Human))	BDBM50215926 (4-(4,5-dibromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]py...) Show SMILES Nc1nc2c(nccc2[nH]1)-c1cc(Br)c(Br)[nH]1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	924	n/a	n/a	n/a	n/a	n/a	n/a
Macquarie University Curated by ChEMBL					Assay Description Inhibition of MMP12				J Med Chem 54: 2492-503 (2011) Article DOI: 10.1021/jm200039m BindingDB Entry DOI: 10.7270/Q2QV3NMT
Macquarie University Curated by ChEMBL					More data for this Ligand-Target Pair
Macrophage metalloelastase (Homo sapiens (Human))	BDBM50215926 (4-(4,5-dibromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]py...) Show SMILES Nc1nc2c(nccc2[nH]1)-c1cc(Br)c(Br)[nH]1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.66E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wroclaw University of Economics Curated by ChEMBL					Assay Description Inhibition of MMP12 (unknown origin)				Bioorg Med Chem 23: 6087-99 (2015) Article DOI: 10.1016/j.bmc.2015.07.045 BindingDB Entry DOI: 10.7270/Q2S75J31
Wroclaw University of Economics Curated by ChEMBL					More data for this Ligand-Target Pair
Macrophage metalloelastase (Homo sapiens (Human))	BDBM50215926 (4-(4,5-dibromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]py...) Show SMILES Nc1nc2c(nccc2[nH]1)-c1cc(Br)c(Br)[nH]1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.66E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kyorin Pharmaceutical Co., Ltd Curated by ChEMBL					Assay Description Inhibition of human MMP12 catalytic domain				Bioorg Med Chem Lett 19: 5461-3 (2009) Article DOI: 10.1016/j.bmcl.2009.07.099 BindingDB Entry DOI: 10.7270/Q2HX1CRC
Kyorin Pharmaceutical Co., Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Macrophage metalloelastase (Homo sapiens (Human))	BDBM50215926 (4-(4,5-dibromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]py...) Show SMILES Nc1nc2c(nccc2[nH]1)-c1cc(Br)c(Br)[nH]1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.66E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kyorin Pharmaceutical Co. Ltd Curated by ChEMBL					Assay Description Inhibition of MMP12				Bioorg Med Chem Lett 17: 4495-9 (2007) Article DOI: 10.1016/j.bmcl.2007.06.005 BindingDB Entry DOI: 10.7270/Q2MW2GVX
Kyorin Pharmaceutical Co. Ltd Curated by ChEMBL					More data for this Ligand-Target Pair