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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mast/stem cell growth factor receptor Kit (Homo sapiens (Human)) | BDBM50515229 (CHEMBL4577779) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet  | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of human KIT | J Med Chem 62: 6083-6101 (2019) Article DOI: 10.1021/acs.jmedchem.9b00280 BindingDB Entry DOI: 10.7270/Q21Z47S9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mast/stem cell growth factor receptor Kit (Homo sapiens (Human)) | BDBM50515229 (CHEMBL4577779) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of human N-terminal GST-tagged KIT V559D/T670I double mutant (544 to end residues) expressed in baculovirus infected Sf9 insect cells by L... | J Med Chem 62: 6083-6101 (2019) Article DOI: 10.1021/acs.jmedchem.9b00280 BindingDB Entry DOI: 10.7270/Q21Z47S9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mast/stem cell growth factor receptor Kit (Homo sapiens (Human)) | BDBM50515229 (CHEMBL4577779) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | <100 | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of c-KIT 560 to 578 deletion mutant in human GISTT1 cells assessed as reduction in c-KIT autophosphorylation at Y703 residue measured afte... | J Med Chem 62: 6083-6101 (2019) Article DOI: 10.1021/acs.jmedchem.9b00280 BindingDB Entry DOI: 10.7270/Q21Z47S9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mast/stem cell growth factor receptor Kit (Homo sapiens (Human)) | BDBM50515229 (CHEMBL4577779) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | <100 | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of c-KIT 560 to 578 deletion mutant in human GISTT1 cells assessed as reduction in AKT phosphorylation at T308 residue measured after 2 hr... | J Med Chem 62: 6083-6101 (2019) Article DOI: 10.1021/acs.jmedchem.9b00280 BindingDB Entry DOI: 10.7270/Q21Z47S9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mast/stem cell growth factor receptor Kit (Homo sapiens (Human)) | BDBM50515229 (CHEMBL4577779) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | <100 | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of c-KIT 560 to 578 deletion mutant in human GISTT1 cells assessed as reduction in c-KIT autophosphorylation at Y719 residue measured afte... | J Med Chem 62: 6083-6101 (2019) Article DOI: 10.1021/acs.jmedchem.9b00280 BindingDB Entry DOI: 10.7270/Q21Z47S9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mast/stem cell growth factor receptor Kit (Homo sapiens (Human)) | BDBM50515229 (CHEMBL4577779) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | <100 | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of c-KIT 560 to 578 deletion/T670I mutant in human GISTT1 cells assessed as reduction in c-KIT autophosphorylation at Y703 residue measure... | J Med Chem 62: 6083-6101 (2019) Article DOI: 10.1021/acs.jmedchem.9b00280 BindingDB Entry DOI: 10.7270/Q21Z47S9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mast/stem cell growth factor receptor Kit (Homo sapiens (Human)) | BDBM50515229 (CHEMBL4577779) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | <100 | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of c-KIT 560 to 578 deletion/T670I mutant in human GISTT1 cells assessed as reduction in c-KIT autophosphorylation at Y719 residue measure... | J Med Chem 62: 6083-6101 (2019) Article DOI: 10.1021/acs.jmedchem.9b00280 BindingDB Entry DOI: 10.7270/Q21Z47S9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mast/stem cell growth factor receptor Kit (Homo sapiens (Human)) | BDBM50515229 (CHEMBL4577779) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | <100 | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of c-KIT 560 to 578 deletion/T670I mutant in human GISTT1 cells assessed as reduction in c-KIT autophosphorylation at Y823 residue measure... | J Med Chem 62: 6083-6101 (2019) Article DOI: 10.1021/acs.jmedchem.9b00280 BindingDB Entry DOI: 10.7270/Q21Z47S9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mast/stem cell growth factor receptor Kit (Homo sapiens (Human)) | BDBM50515229 (CHEMBL4577779) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | <100 | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of c-KIT 560 to 578 deletion/T670I mutant in human GIST5R cells assessed as reduction in c-KIT autophosphorylation at Y823 residue measure... | J Med Chem 62: 6083-6101 (2019) Article DOI: 10.1021/acs.jmedchem.9b00280 BindingDB Entry DOI: 10.7270/Q21Z47S9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mast/stem cell growth factor receptor Kit (Homo sapiens (Human)) | BDBM50515229 (CHEMBL4577779) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | <100 | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of c-KIT 560 to 578 deletion mutant in human GISTT1 cells assessed as reduction in AKT phosphorylation at S473 residue measured after 2 hr... | J Med Chem 62: 6083-6101 (2019) Article DOI: 10.1021/acs.jmedchem.9b00280 BindingDB Entry DOI: 10.7270/Q21Z47S9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mast/stem cell growth factor receptor Kit (Homo sapiens (Human)) | BDBM50515229 (CHEMBL4577779) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | <100 | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of c-KIT 560 to 578 deletion mutant in human GISTT1 cells assessed as reduction in pS6 phosphorylation at S236 residue measured after 2 hr... | J Med Chem 62: 6083-6101 (2019) Article DOI: 10.1021/acs.jmedchem.9b00280 BindingDB Entry DOI: 10.7270/Q21Z47S9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mast/stem cell growth factor receptor Kit (Homo sapiens (Human)) | BDBM50515229 (CHEMBL4577779) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | <100 | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of c-KIT 560 to 578 deletion mutant in human GISTT1 cells assessed as reduction in ERK phosphorylation at T202 residue measured after 2 hr... | J Med Chem 62: 6083-6101 (2019) Article DOI: 10.1021/acs.jmedchem.9b00280 BindingDB Entry DOI: 10.7270/Q21Z47S9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mast/stem cell growth factor receptor Kit (Homo sapiens (Human)) | BDBM50515229 (CHEMBL4577779) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | <100 | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of c-KIT 560 to 578 deletion mutant in human GISTT1 cells assessed as reduction in ERK phosphorylation at T204 residue measured after 2 hr... | J Med Chem 62: 6083-6101 (2019) Article DOI: 10.1021/acs.jmedchem.9b00280 BindingDB Entry DOI: 10.7270/Q21Z47S9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mast/stem cell growth factor receptor Kit (Homo sapiens (Human)) | BDBM50515229 (CHEMBL4577779) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | <100 | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of c-KIT 560 to 578 deletion/T670I mutant in human GISTT1 cells assessed as reduction in AKT phosphorylation at S473 residue measured afte... | J Med Chem 62: 6083-6101 (2019) Article DOI: 10.1021/acs.jmedchem.9b00280 BindingDB Entry DOI: 10.7270/Q21Z47S9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mast/stem cell growth factor receptor Kit (Homo sapiens (Human)) | BDBM50515229 (CHEMBL4577779) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | <100 | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of c-KIT 560 to 578 deletion/T670I mutant in human GISTT1 cells assessed as reduction in pS6 phosphorylation at S236 residue measured afte... | J Med Chem 62: 6083-6101 (2019) Article DOI: 10.1021/acs.jmedchem.9b00280 BindingDB Entry DOI: 10.7270/Q21Z47S9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mast/stem cell growth factor receptor Kit (Homo sapiens (Human)) | BDBM50515229 (CHEMBL4577779) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | <100 | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of c-KIT 560 to 578 deletion/T670I mutant in human GIST5R assessed as reduction in AKT phosphorylation at T308 residue measured after 2 hr... | J Med Chem 62: 6083-6101 (2019) Article DOI: 10.1021/acs.jmedchem.9b00280 BindingDB Entry DOI: 10.7270/Q21Z47S9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mast/stem cell growth factor receptor Kit (Homo sapiens (Human)) | BDBM50515229 (CHEMBL4577779) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | <100 | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of c-KIT 560 to 578 deletion/T670I mutant in human GIST5R assessed as reduction in AKT phosphorylation at S473 residue measured after 2 hr... | J Med Chem 62: 6083-6101 (2019) Article DOI: 10.1021/acs.jmedchem.9b00280 BindingDB Entry DOI: 10.7270/Q21Z47S9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mast/stem cell growth factor receptor Kit (Homo sapiens (Human)) | BDBM50515229 (CHEMBL4577779) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | <100 | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of c-KIT 560 to 578 deletion/T670I mutant in human GIST5R assessed as reduction in pS6 phosphorylation at S235 residue measured after 2 hr... | J Med Chem 62: 6083-6101 (2019) Article DOI: 10.1021/acs.jmedchem.9b00280 BindingDB Entry DOI: 10.7270/Q21Z47S9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mast/stem cell growth factor receptor Kit (Homo sapiens (Human)) | BDBM50515229 (CHEMBL4577779) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | <100 | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of c-KIT 560 to 578 deletion/T670I mutant in human GIST5R assessed as reduction in ERK phosphorylation at T202 residue measured after 2 hr... | J Med Chem 62: 6083-6101 (2019) Article DOI: 10.1021/acs.jmedchem.9b00280 BindingDB Entry DOI: 10.7270/Q21Z47S9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mast/stem cell growth factor receptor Kit (Homo sapiens (Human)) | BDBM50515229 (CHEMBL4577779) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | <100 | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of c-KIT 560 to 578 deletion/T670I mutant in human GIST5R cells assessed as reduction in c-KIT autophosphorylation at Y703 residue measure... | J Med Chem 62: 6083-6101 (2019) Article DOI: 10.1021/acs.jmedchem.9b00280 BindingDB Entry DOI: 10.7270/Q21Z47S9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mast/stem cell growth factor receptor Kit (Homo sapiens (Human)) | BDBM50515229 (CHEMBL4577779) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | <100 | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of c-KIT 560 to 578 deletion/T670I mutant in human GISTT1 cells assessed as reduction in ERK phosphorylation at T202 residue measured afte... | J Med Chem 62: 6083-6101 (2019) Article DOI: 10.1021/acs.jmedchem.9b00280 BindingDB Entry DOI: 10.7270/Q21Z47S9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mast/stem cell growth factor receptor Kit (Homo sapiens (Human)) | BDBM50515229 (CHEMBL4577779) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | <100 | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of c-KIT 560 to 578 deletion/T670I mutant in human GIST5R cells assessed as reduction in c-KIT autophosphorylation at Y719 residue measure... | J Med Chem 62: 6083-6101 (2019) Article DOI: 10.1021/acs.jmedchem.9b00280 BindingDB Entry DOI: 10.7270/Q21Z47S9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mast/stem cell growth factor receptor Kit (Homo sapiens (Human)) | BDBM50515229 (CHEMBL4577779) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | <100 | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of c-KIT 560 to 578 deletion mutant in human GISTT1 cells assessed as reduction in pS6 phosphorylation at S235 residue measured after 2 hr... | J Med Chem 62: 6083-6101 (2019) Article DOI: 10.1021/acs.jmedchem.9b00280 BindingDB Entry DOI: 10.7270/Q21Z47S9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mast/stem cell growth factor receptor Kit (Homo sapiens (Human)) | BDBM50515229 (CHEMBL4577779) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | <100 | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of c-KIT 560 to 578 deletion/T670I mutant in human GISTT1 cells assessed as reduction in AKT phosphorylation at T308 residue measured afte... | J Med Chem 62: 6083-6101 (2019) Article DOI: 10.1021/acs.jmedchem.9b00280 BindingDB Entry DOI: 10.7270/Q21Z47S9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mast/stem cell growth factor receptor Kit (Homo sapiens (Human)) | BDBM50515229 (CHEMBL4577779) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | <100 | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of c-KIT 560 to 578 deletion/T670I mutant in human GISTT1 cells assessed as reduction in ERK phosphorylation at T204 residue measured afte... | J Med Chem 62: 6083-6101 (2019) Article DOI: 10.1021/acs.jmedchem.9b00280 BindingDB Entry DOI: 10.7270/Q21Z47S9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mast/stem cell growth factor receptor Kit (Homo sapiens (Human)) | BDBM50515229 (CHEMBL4577779) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | <100 | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of c-KIT 560 to 578 deletion/T670I mutant in human GIST5R assessed as reduction in pS6 phosphorylation at S236 residue measured after 2 hr... | J Med Chem 62: 6083-6101 (2019) Article DOI: 10.1021/acs.jmedchem.9b00280 BindingDB Entry DOI: 10.7270/Q21Z47S9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mast/stem cell growth factor receptor Kit (Homo sapiens (Human)) | BDBM50515229 (CHEMBL4577779) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | <100 | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of c-KIT 560 to 578 deletion mutant in human GISTT1 cells assessed as reduction in c-KIT autophosphorylation at Y823 residue measured afte... | J Med Chem 62: 6083-6101 (2019) Article DOI: 10.1021/acs.jmedchem.9b00280 BindingDB Entry DOI: 10.7270/Q21Z47S9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mast/stem cell growth factor receptor Kit (Homo sapiens (Human)) | BDBM50515229 (CHEMBL4577779) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | <100 | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of c-KIT 560 to 578 deletion/T670I mutant in human GISTT1 cells assessed as reduction in pS6 phosphorylation at S235 residue measured afte... | J Med Chem 62: 6083-6101 (2019) Article DOI: 10.1021/acs.jmedchem.9b00280 BindingDB Entry DOI: 10.7270/Q21Z47S9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mast/stem cell growth factor receptor Kit (Homo sapiens (Human)) | BDBM50515229 (CHEMBL4577779) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | <100 | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of c-KIT 560 to 578 deletion/T670I mutant in human GIST5R assessed as reduction in ERK phosphorylation at T204 residue measured after 2 hr... | J Med Chem 62: 6083-6101 (2019) Article DOI: 10.1021/acs.jmedchem.9b00280 BindingDB Entry DOI: 10.7270/Q21Z47S9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
