BindingDB PrimarySearch

Found 11 hits Enz. Inhib. hit(s) with Target = 'Mu-type opioid receptor' and Ligand = 'BDBM50176259'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50176259 ((1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphen...) Show SMILES COc1cccc(c1)[C@@]1(O)CCCC[C@@H]1CN(C)C Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars	DrugBank Article PubMed	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Rensselaer Polytechnic Institute Curated by ChEMBL					Assay Description Activity at human cloned mu opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assay				Bioorg Med Chem Lett 19: 203-8 (2008) Article DOI: 10.1016/j.bmcl.2008.10.134 BindingDB Entry DOI: 10.7270/Q2RX9D1K
Rensselaer Polytechnic Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50176259 ((1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphen...) Show SMILES COc1cccc(c1)[C@@]1(O)CCCC[C@@H]1CN(C)C Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars	DrugBank Article PubMed	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Opioid receptor mu 1 agonist activity with monoamine (NE, 5-HT) uptake-blocking activity in the 0.8-1 uM range				J Med Chem 42: 1481-500 (1999) Article DOI: 10.1021/jm9805034 BindingDB Entry DOI: 10.7270/Q2HX1DCV
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Mu-type opioid receptor (Rattus norvegicus (rat))	BDBM50176259 ((1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphen...) Show SMILES COc1cccc(c1)[C@@]1(O)CCCC[C@@H]1CN(C)C Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wroclaw Medical University Curated by ChEMBL					Assay Description Displacement of [3H]-dihydromorphine from mu opioid receptor in rat cerebral cortex by liquid scintillation counting				Eur J Med Chem 46: 4992-9 (2011) Article DOI: 10.1016/j.ejmech.2011.08.006 BindingDB Entry DOI: 10.7270/Q27S7P5W
Wroclaw Medical University Curated by ChEMBL					More data for this Ligand-Target Pair
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50176259 ((1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphen...) Show SMILES COc1cccc(c1)[C@@]1(O)CCCC[C@@H]1CN(C)C Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars	DrugBank Article PubMed	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Fudan University Curated by ChEMBL					Assay Description Binding affinity towards aldosterone receptor (Mineralocorticoid receptor)				ACS Med Chem Lett 7: 391-6 (2016) Article DOI: 10.1021/acsmedchemlett.5b00423 BindingDB Entry DOI: 10.7270/Q2R78H4W
Fudan University Curated by ChEMBL					More data for this Ligand-Target Pair
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50176259 ((1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphen...) Show SMILES COc1cccc(c1)[C@@]1(O)CCCC[C@@H]1CN(C)C Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	5.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sepracor Inc. Curated by ChEMBL					Assay Description Inhibition of mu opioid receptor				Bioorg Med Chem Lett 16: 691-4 (2005) Article DOI: 10.1016/j.bmcl.2005.10.024 BindingDB Entry DOI: 10.7270/Q2MG7Q9D
Sepracor Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50176259 ((1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphen...) Show SMILES COc1cccc(c1)[C@@]1(O)CCCC[C@@H]1CN(C)C Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	7.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sepracor Inc. Curated by ChEMBL					Assay Description Inhibition of mu opioid receptor				Bioorg Med Chem Lett 16: 691-4 (2005) Article DOI: 10.1016/j.bmcl.2005.10.024 BindingDB Entry DOI: 10.7270/Q2MG7Q9D
Sepracor Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50176259 ((1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphen...) Show SMILES COc1cccc(c1)[C@@]1(O)CCCC[C@@H]1CN(C)C Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	7.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sepracor Inc. Curated by ChEMBL					Assay Description Binding affinity to mu opioid receptor				Bioorg Med Chem Lett 18: 1674-80 (2008) Article DOI: 10.1016/j.bmcl.2008.01.051 BindingDB Entry DOI: 10.7270/Q2VQ33HQ
Sepracor Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50176259 ((1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphen...) Show SMILES COc1cccc(c1)[C@@]1(O)CCCC[C@@H]1CN(C)C Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sepracor Inc. Curated by ChEMBL					Assay Description Inhibition of mu opioid receptor				Bioorg Med Chem Lett 16: 691-4 (2005) Article DOI: 10.1016/j.bmcl.2005.10.024 BindingDB Entry DOI: 10.7270/Q2MG7Q9D
Sepracor Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50176259 ((1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphen...) Show SMILES COc1cccc(c1)[C@@]1(O)CCCC[C@@H]1CN(C)C Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sepracor Inc. Curated by ChEMBL					Assay Description Inhibition of mu opioid receptor				Bioorg Med Chem Lett 16: 691-4 (2005) Article DOI: 10.1016/j.bmcl.2005.10.024 BindingDB Entry DOI: 10.7270/Q2MG7Q9D
Sepracor Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50176259 ((1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphen...) Show SMILES COc1cccc(c1)[C@@]1(O)CCCC[C@@H]1CN(C)C Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a
Fudan University Curated by ChEMBL					Assay Description Agonist activity at human MOR expressed in CHO cell membranes after 60 mins by [35S]GTP-gamma-S binding assay				ACS Med Chem Lett 7: 391-6 (2016) Article DOI: 10.1021/acsmedchemlett.5b00423 BindingDB Entry DOI: 10.7270/Q2R78H4W
Fudan University Curated by ChEMBL					More data for this Ligand-Target Pair
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50176259 ((1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphen...) Show SMILES COc1cccc(c1)[C@@]1(O)CCCC[C@@H]1CN(C)C Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity at human mu opioid receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 1 hr by HTRF ...				ACS Med Chem Lett 3: 227-231 (2012) Article DOI: 10.1021/ml200268w BindingDB Entry DOI: 10.7270/Q2TX3GF4
TBA Curated by ChEMBL					More data for this Ligand-Target Pair