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Compile Data Set for Download or QSAR

Found 4 hits Enz. Inhib. hit(s) with Target = 'Platelet-activating factor receptor' and Ligand = 'BDBM50002831'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet-activating factor receptor


(Homo sapiens (Human))
BDBM50002831
PNG
((2R,5R)-2,5-Bis-(3,4,5-trimethoxy-phenyl)-tetrahyd...)
Show SMILES COc1cc(cc(OC)c1OC)[C@@H]1CC[C@H](O1)c1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C22H28O7/c1-23-17-9-13(10-18(24-2)21(17)27-5)15-7-8-16(29-15)14-11-19(25-3)22(28-6)20(12-14)26-4/h9-12,15-16H,7-8H2,1-6H3/t15-,16-/m0/s1
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215n/an/an/an/an/an/an/an/a



Rhone-Poulenc Sante

Curated by PDSP Ki Database




J Pharmacol Exp Ther 252: 1221-7 (1990)


BindingDB Entry DOI: 10.7270/Q2JW8CC2
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))
BDBM50002831
PNG
((2R,5R)-2,5-Bis-(3,4,5-trimethoxy-phenyl)-tetrahyd...)
Show SMILES COc1cc(cc(OC)c1OC)[C@@H]1CC[C@H](O1)c1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C22H28O7/c1-23-17-9-13(10-18(24-2)21(17)27-5)15-7-8-16(29-15)14-11-19(25-3)22(28-6)20(12-14)26-4/h9-12,15-16H,7-8H2,1-6H3/t15-,16-/m0/s1
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268n/an/an/an/an/an/an/an/a



Rhone-Poulenc Sante

Curated by PDSP Ki Database




J Pharmacol Exp Ther 252: 1221-7 (1990)


BindingDB Entry DOI: 10.7270/Q2JW8CC2
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)
BDBM50002831
PNG
((2R,5R)-2,5-Bis-(3,4,5-trimethoxy-phenyl)-tetrahyd...)
Show SMILES COc1cc(cc(OC)c1OC)[C@@H]1CC[C@H](O1)c1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C22H28O7/c1-23-17-9-13(10-18(24-2)21(17)27-5)15-7-8-16(29-15)14-11-19(25-3)22(28-6)20(12-14)26-4/h9-12,15-16H,7-8H2,1-6H3/t15-,16-/m0/s1
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n/an/a 20n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of PAF receptor binding to rabbit platelet plasma membranes


J Med Chem 29: 1917-21 (1986)


BindingDB Entry DOI: 10.7270/Q2X63KZS
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))
BDBM50002831
PNG
((2R,5R)-2,5-Bis-(3,4,5-trimethoxy-phenyl)-tetrahyd...)
Show SMILES COc1cc(cc(OC)c1OC)[C@@H]1CC[C@H](O1)c1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C22H28O7/c1-23-17-9-13(10-18(24-2)21(17)27-5)15-7-8-16(29-15)14-11-19(25-3)22(28-6)20(12-14)26-4/h9-12,15-16H,7-8H2,1-6H3/t15-,16-/m0/s1
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n/an/a 1.50E+3n/an/an/an/an/an/a



Schering-Plough Corporation

Curated by ChEMBL


Assay Description
Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when ch...


J Med Chem 34: 457-61 (1991)


BindingDB Entry DOI: 10.7270/Q2BV7FK0
More data for this
Ligand-Target Pair