Found 4 hits Enz. Inhib. hit(s) with Target = 'Short transient receptor potential channel 5' and Ligand = 'BDBM50529421' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Short transient receptor potential channel 5
(Homo sapiens (Human)) | BDBM50529421
(CHEMBL4530872)Show SMILES FC(F)(F)c1ccccc1CN1CCN(CC1=O)c1cn[nH]c(=O)c1Cl Show InChI InChI=1S/C16H14ClF3N4O2/c17-14-12(7-21-22-15(14)26)23-5-6-24(13(25)9-23)8-10-3-1-2-4-11(10)16(18,19)20/h1-4,7H,5-6,8-9H2,(H,22,26) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
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MCE PC cid PC sid PDB UniChem
| Article PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128612 BindingDB Entry DOI: 10.7270/Q2P84GX0 |
More data for this Ligand-Target Pair | |
Short transient receptor potential channel 5
(Homo sapiens (Human)) | BDBM50529421
(CHEMBL4530872)Show SMILES FC(F)(F)c1ccccc1CN1CCN(CC1=O)c1cn[nH]c(=O)c1Cl Show InChI InChI=1S/C16H14ClF3N4O2/c17-14-12(7-21-22-15(14)26)23-5-6-24(13(25)9-23)8-10-3-1-2-4-11(10)16(18,19)20/h1-4,7H,5-6,8-9H2,(H,22,26) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid PDB UniChem
| Article PubMed
| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Goldfinch Bio Inc.
Curated by ChEMBL
| Assay Description Inhibition of rosiglitazone-activated human TRPC5 channel expressed in HEK293 cells assessed as reduction in Ca2+ current measured at +80 mV with hol... |
ACS Med Chem Lett 10: 1579-1585 (2019)
Article DOI: 10.1021/acsmedchemlett.9b00430 BindingDB Entry DOI: 10.7270/Q2DN48HF |
More data for this Ligand-Target Pair | |
Short transient receptor potential channel 5
(Homo sapiens (Human)) | BDBM50529421
(CHEMBL4530872)Show SMILES FC(F)(F)c1ccccc1CN1CCN(CC1=O)c1cn[nH]c(=O)c1Cl Show InChI InChI=1S/C16H14ClF3N4O2/c17-14-12(7-21-22-15(14)26)23-5-6-24(13(25)9-23)8-10-3-1-2-4-11(10)16(18,19)20/h1-4,7H,5-6,8-9H2,(H,22,26) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid PDB UniChem
| Article PubMed
| n/a | n/a | 211 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128612 BindingDB Entry DOI: 10.7270/Q2P84GX0 |
More data for this Ligand-Target Pair | |
Short transient receptor potential channel 5
(Homo sapiens (Human)) | BDBM50529421
(CHEMBL4530872)Show SMILES FC(F)(F)c1ccccc1CN1CCN(CC1=O)c1cn[nH]c(=O)c1Cl Show InChI InChI=1S/C16H14ClF3N4O2/c17-14-12(7-21-22-15(14)26)23-5-6-24(13(25)9-23)8-10-3-1-2-4-11(10)16(18,19)20/h1-4,7H,5-6,8-9H2,(H,22,26) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid PDB UniChem
| Article PubMed
| n/a | n/a | 280 | n/a | n/a | n/a | n/a | n/a | n/a |
Goldfinch Bio Inc.
Curated by ChEMBL
| Assay Description Inhibition of human TRPC5 channel expressed in HEK293 cells assessed as decrease in current amplitude treated for 3 mins measured between +80 mV and ... |
ACS Med Chem Lett 10: 1579-1585 (2019)
Article DOI: 10.1021/acsmedchemlett.9b00430 BindingDB Entry DOI: 10.7270/Q2DN48HF |
More data for this Ligand-Target Pair | |