Reaction Details |
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Target | Short transient receptor potential channel 5 |
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Ligand | BDBM50529421 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1908633 (CHEMBL4410991) |
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IC50 | 280±n/a nM |
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Citation | Yu, M; Ledeboer, MW; Daniels, M; Malojcic, G; Tibbitts, TT; Coeffet-Le Gal, M; Pan-Zhou, XR; Westerling-Bui, A; Beconi, M; Reilly, JF; Mundel, P; Harmange, JC Discovery of a Potent and Selective TRPC5 Inhibitor, Efficacious in a Focal Segmental Glomerulosclerosis Model. ACS Med Chem Lett10:1579-1585 (2019) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Short transient receptor potential channel 5 |
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Name: | Short transient receptor potential channel 5 |
Synonyms: | TRP5 | TRPC5 | TRPC5_HUMAN | Transient receptor protein 5 (TRPC5) |
Type: | Enzyme |
Mol. Mass.: | 111421.47 |
Organism: | Homo sapiens (Human) |
Description: | Q9UL62 |
Residue: | 973 |
Sequence: | MAQLYYKKVNYSPYRDRIPLQIVRAETELSAEEKAFLNAVEKGDYATVKQALQEAEIYYN
VNINCMDPLGRSALLIAIENENLEIMELLLNHSVYVGDALLYAIRKEVVGAVELLLSYRR
PSGEKQVPTLMMDTQFSEFTPDITPIMLAAHTNNYEIIKLLVQKRVTIPRPHQIRCNCVE
CVSSSEVDSLRHSRSRLNIYKALASPSLIALSSEDPILTAFRLGWELKELSKVENEFKAE
YEELSQQCKLFAKDLLDQARSSRELEIILNHRDDHSEELDPQKYHDLAKLKVAIKYHQKE
FVAQPNCQQLLATLWYDGFPGWRRKHWVVKLLTCMTIGFLFPMLSIAYLISPRSNLGLFI
KKPFIKFICHTASYLTFLFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGEIK
EMWDGGFTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEMWHPTLIAEA
LFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYF
YYETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTEFV
GATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFDEGGTLPPP
FNIIPSPKSFLYLGNWFNNTFCPKRDPDGRRRRRNLRSFTERNADSLIQNQHYQEVIRNL
VKRYVAAMIRNSKTHEGLTEENFKELKQDISSFRYEVLDLLGNRKHPRSFSTSSTELSQR
DDNNDGSGGARAKSKSVSFNLGCKKKTCHGPPLIRTMPRSSGAQGKSKAESSSKRSFMGP
SLKKLGLLFSKFNGHMSEPSSEPMYTISDGIVQQHCMWQDIRYSQMEKGKAEACSQSEIN
LSEVELGEVQGAAQSSECPLACSSSLHCASSICSSNSKLLDSSEDVFETWGEACDLLMHK
WGDGQEEQVTTRL
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BDBM50529421 |
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n/a |
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Name | BDBM50529421 |
Synonyms: | CHEMBL4530872 |
Type | Small organic molecule |
Emp. Form. | C16H14ClF3N4O2 |
Mol. Mass. | 386.756 |
SMILES | FC(F)(F)c1ccccc1CN1CCN(CC1=O)c1cn[nH]c(=O)c1Cl |
Structure |
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