BindingDB PrimarySearch

Found 16 hits Enz. Inhib. hit(s) with Target = 'Sterol O-acyltransferase 1' and Ligand = 'BDBM50005944'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Sterol O-acyltransferase 1 (Rattus norvegicus)	BDBM50005944 (2,2-Dimethyl-dodecanoic acid (2,4,6-trimethoxy-phe...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	73	n/a	n/a	n/a	n/a	n/a	n/a
Parke-Davis Pharmaceutical Research Curated by ChEMBL					Assay Description In vitro inhibition of rat intestinal acyl coenzyme A:cholesterol acyltransferase using [1-14C]oleolyl-CoA				J Med Chem 37: 1810-22 (1994) BindingDB Entry DOI: 10.7270/Q2CR5V0V
Parke-Davis Pharmaceutical Research Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Sterol O-acyltransferase 1 (Rattus norvegicus)	BDBM50005944 (2,2-Dimethyl-dodecanoic acid (2,4,6-trimethoxy-phe...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
Warner-Lambert Company Curated by ChEMBL					Assay Description Concentration required for the in vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase (ACAT) in liver microsomes isolated from cholestero...				Bioorg Med Chem Lett 5: 295-300 (1995) BindingDB Entry DOI: 10.7270/Q29Z94WS
Warner-Lambert Company Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Sterol O-acyltransferase 1 (Rattus norvegicus)	BDBM50005944 (2,2-Dimethyl-dodecanoic acid (2,4,6-trimethoxy-phe...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Concentration required for the in vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase (ACAT) in liver microsomes isolated from cholestero...				Bioorg Med Chem Lett 5: 289-294 (1995) Article DOI: 10.1016/0960-894X(95)00024-N BindingDB Entry DOI: 10.7270/Q2FQ9WKP
TBA Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Sterol O-acyltransferase 1 (Rattus norvegicus)	BDBM50005944 (2,2-Dimethyl-dodecanoic acid (2,4,6-trimethoxy-phe...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	149	n/a	n/a	n/a	n/a	n/a	n/a
Institute for Bio-Medical Research Curated by ChEMBL					Assay Description Inhibitory activity of the compound against Acyl coenzyme A:cholesterol acyltransferase 1 obtained from rat liver microsomes				J Med Chem 39: 1262-70 (1996) Article DOI: 10.1021/jm950828+ BindingDB Entry DOI: 10.7270/Q24T6HGW
Institute for Bio-Medical Research Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Sterol O-acyltransferase 1 (Homo sapiens (Human))	BDBM50005944 (2,2-Dimethyl-dodecanoic acid (2,4,6-trimethoxy-phe...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Kansas State University Curated by ChEMBL					Assay Description Inhibition of ACAT activity in human MC65 cells using NBD-cholesterol staining after 48 hrs by fluorescence assay				J Med Chem 55: 8969-73 (2012) Article DOI: 10.1021/jm3012189 BindingDB Entry DOI: 10.7270/Q2000370
Kansas State University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Sterol O-acyltransferase 1 (Mus musculus)	BDBM50005944 (2,2-Dimethyl-dodecanoic acid (2,4,6-trimethoxy-phe...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	310	n/a	n/a	n/a	n/a	n/a	n/a
Kowa Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of ACAT1 in mouse J774 cells assessed as reduction in esterified cholesterol accumulation after 18 hrs in presence of 25-hydroxycholestero...				Bioorg Med Chem 26: 4001-4013 (2018) Article DOI: 10.1016/j.bmc.2018.06.024 BindingDB Entry DOI: 10.7270/Q22F7R3T
Kowa Co., Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Sterol O-acyltransferase 1 (Mus musculus)	BDBM50005944 (2,2-Dimethyl-dodecanoic acid (2,4,6-trimethoxy-phe...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound was tested for its ability to penetrate the cell wall and inhibit macrophage ACAT in cell culture using murine IC-21 macrophages (MAI)				Bioorg Med Chem Lett 6: 1753-1758 (1996) Article DOI: 10.1016/0960-894X(96)00310-1 BindingDB Entry DOI: 10.7270/Q2VD6ZF6
TBA Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Sterol O-acyltransferase 1 (Homo sapiens (Human))	BDBM50005944 (2,2-Dimethyl-dodecanoic acid (2,4,6-trimethoxy-phe...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	619	n/a	n/a	n/a	n/a	n/a	n/a
Azwell Inc. Curated by ChEMBL					Assay Description Compound was tested for inhibitory activity against ACAT from canine intestine				Bioorg Med Chem Lett 9: 2039-42 (1999) BindingDB Entry DOI: 10.7270/Q2FF3RJJ
Azwell Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Sterol O-acyltransferase 1 (Homo sapiens (Human))	BDBM50005944 (2,2-Dimethyl-dodecanoic acid (2,4,6-trimethoxy-phe...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	838	n/a	n/a	n/a	n/a	n/a	n/a
Azwell Inc. Curated by ChEMBL					Assay Description Compound was tested for inhibitory activity against ACAT from HepG2 microsome in human				Bioorg Med Chem Lett 9: 2039-42 (1999) BindingDB Entry DOI: 10.7270/Q2FF3RJJ
Azwell Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Sterol O-acyltransferase 1 (Homo sapiens (Human))	BDBM50005944 (2,2-Dimethyl-dodecanoic acid (2,4,6-trimethoxy-phe...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	926	n/a	n/a	n/a	n/a	n/a	n/a
Azwell Inc. Curated by ChEMBL					Assay Description Compound was tested for inhibitory activity against ACAT from U937 microsome in human				Bioorg Med Chem Lett 9: 2039-42 (1999) BindingDB Entry DOI: 10.7270/Q2FF3RJJ
Azwell Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Sterol O-acyltransferase 1 (Homo sapiens (Human))	BDBM50005944 (2,2-Dimethyl-dodecanoic acid (2,4,6-trimethoxy-phe...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	4.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of Acyl coenzyme A:cholesterol acyltransferase (ACAT)				J Med Chem 24: 496-9 (1981) BindingDB Entry DOI: 10.7270/Q2K64JTV
TBA Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Sterol O-acyltransferase 1 (Homo sapiens (Human))	BDBM50005944 (2,2-Dimethyl-dodecanoic acid (2,4,6-trimethoxy-phe...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	4.59E+3	n/a	n/a	n/a	n/a	n/a	n/a
Azwell Inc. Curated by ChEMBL					Assay Description Compound was tested for inhibitory activity against ACAT from HepG2 microsome in human				Bioorg Med Chem Lett 9: 2039-42 (1999) BindingDB Entry DOI: 10.7270/Q2FF3RJJ
Azwell Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Sterol O-acyltransferase 1 (Homo sapiens (Human))	BDBM50005944 (2,2-Dimethyl-dodecanoic acid (2,4,6-trimethoxy-phe...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	4.65E+3	n/a	n/a	n/a	n/a	n/a	n/a
Azwell Inc. Curated by ChEMBL					Assay Description Compound was tested for inhibitory activity against ACAT from canine adrenal gland				Bioorg Med Chem Lett 9: 2039-42 (1999) BindingDB Entry DOI: 10.7270/Q2FF3RJJ
Azwell Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Sterol O-acyltransferase 1 (Homo sapiens (Human))	BDBM50005944 (2,2-Dimethyl-dodecanoic acid (2,4,6-trimethoxy-phe...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	5.87E+3	n/a	n/a	n/a	n/a	n/a	n/a
Azwell Inc. Curated by ChEMBL					Assay Description Compound was tested for inhibitory activity against ACAT from U937 microsome in human				Bioorg Med Chem Lett 9: 2039-42 (1999) BindingDB Entry DOI: 10.7270/Q2FF3RJJ
Azwell Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Sterol O-acyltransferase 1 (Rattus norvegicus)	BDBM50005944 (2,2-Dimethyl-dodecanoic acid (2,4,6-trimethoxy-phe...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	6.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description In vitro inhibition of acyl coenzyme A:cholesterol acyltransferase 1, rat liver microsomal assay				J Med Chem 38: 1600-7 (1995) BindingDB Entry DOI: 10.7270/Q26T0KN9
Schering-Plough Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Sterol O-acyltransferase 1 (Rattus norvegicus)	BDBM50005944 (2,2-Dimethyl-dodecanoic acid (2,4,6-trimethoxy-phe...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	6.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Concentration required for 50% inhibition of Acyl coenzyme A:cholesterol acyltransferase activity using microsomal ACAT assay				J Med Chem 37: 1733-6 (1994) BindingDB Entry DOI: 10.7270/Q20P0Z20
Schering-Plough Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)