BindingDB PrimarySearch

Found 11 hits Enz. Inhib. hit(s) with Target = 'Thromboxane A2 receptor' and Ligand = 'BDBM50188619'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Thromboxane A2 receptor (Homo sapiens (Human))	BDBM50188619 (1-(2-(p-toluidino)-5-nitrophenylsulfonyl)-3-tert-b...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Li&eagrove;ge Curated by PDSP K_i Database									J Pharmacol Exp Ther 313: 293-301 (2005) Article DOI: 10.1124/jpet.104.079301 BindingDB Entry DOI: 10.7270/Q2NV9GVJ
University of Li&eagrove;ge Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Thromboxane A2 receptor (Homo sapiens (Human))	BDBM50188619 (1-(2-(p-toluidino)-5-nitrophenylsulfonyl)-3-tert-b...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Li&eagrove;ge Curated by PDSP K_i Database									J Pharmacol Exp Ther 313: 293-301 (2005) Article DOI: 10.1124/jpet.104.079301 BindingDB Entry DOI: 10.7270/Q2NV9GVJ
University of Li&eagrove;ge Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Thromboxane A2 receptor (Homo sapiens (Human))	BDBM50188619 (1-(2-(p-toluidino)-5-nitrophenylsulfonyl)-3-tert-b...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.780	n/a	n/a	n/a	n/a	n/a	n/a
University of Liège Curated by ChEMBL					Assay Description Displacement of [3H]SQ29,548 from TPbeta receptor (long isoform) expressed in COS7 cells at 1 uM				J Med Chem 49: 3701-9 (2006) Article DOI: 10.1021/jm060108a BindingDB Entry DOI: 10.7270/Q2X63MJT
University of Liège Curated by ChEMBL					More data for this Ligand-Target Pair
Thromboxane A2 receptor (Homo sapiens (Human))	BDBM50188619 (1-(2-(p-toluidino)-5-nitrophenylsulfonyl)-3-tert-b...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.05	n/a	n/a	n/a	n/a	n/a	n/a
University of Liège Curated by ChEMBL					Assay Description Displacement of [3H]SQ29,548 from TPalpha receptor (short isoform) expressed in COS7 cells at 1 uM				J Med Chem 49: 3701-9 (2006) Article DOI: 10.1021/jm060108a BindingDB Entry DOI: 10.7270/Q2X63MJT
University of Liège Curated by ChEMBL					More data for this Ligand-Target Pair
Thromboxane A2 receptor (Homo sapiens (Human))	BDBM50188619 (1-(2-(p-toluidino)-5-nitrophenylsulfonyl)-3-tert-b...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	n/a
University of Liège Curated by ChEMBL					Assay Description Antagonist activity at human thromboxane A2 receptor isoform beta expressed in HEK293 cells assessed as inhibition of U46619-induced calcium mobiliza...				J Med Chem 50: 3928-36 (2007) Article DOI: 10.1021/jm070427h BindingDB Entry DOI: 10.7270/Q2RB7497
University of Liège Curated by ChEMBL					More data for this Ligand-Target Pair
Thromboxane A2 receptor (Homo sapiens (Human))	BDBM50188619 (1-(2-(p-toluidino)-5-nitrophenylsulfonyl)-3-tert-b...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	53.1	n/a	n/a	n/a	n/a	n/a	n/a
University of Liège Curated by ChEMBL					Assay Description Activity at TPbeta (long isoform) receptor expressed in HEK293 cells assessed as ability to antagonize U46619-mediated calcium ion mobilization				J Med Chem 49: 3701-9 (2006) Article DOI: 10.1021/jm060108a BindingDB Entry DOI: 10.7270/Q2X63MJT
University of Liège Curated by ChEMBL					More data for this Ligand-Target Pair
Thromboxane A2 receptor (Homo sapiens (Human))	BDBM50188619 (1-(2-(p-toluidino)-5-nitrophenylsulfonyl)-3-tert-b...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	240	n/a	n/a	n/a	n/a	n/a	n/a
University of Liège Curated by ChEMBL					Assay Description Inhibition of U46619-induced platelet aggregation				J Med Chem 49: 3701-9 (2006) Article DOI: 10.1021/jm060108a BindingDB Entry DOI: 10.7270/Q2X63MJT
University of Liège Curated by ChEMBL					More data for this Ligand-Target Pair
Thromboxane A2 receptor (Homo sapiens (Human))	BDBM50188619 (1-(2-(p-toluidino)-5-nitrophenylsulfonyl)-3-tert-b...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	319	n/a	n/a	n/a	n/a	n/a	n/a
University of Liège Curated by ChEMBL					Assay Description Activity at TPalpha (short isoform) receptor expressed in HEK293 cells assessed as ability to antagonize U46619-mediated calcium ion mobilization				J Med Chem 49: 3701-9 (2006) Article DOI: 10.1021/jm060108a BindingDB Entry DOI: 10.7270/Q2X63MJT
University of Liège Curated by ChEMBL					More data for this Ligand-Target Pair
Thromboxane A2 receptor (Homo sapiens (Human))	BDBM50188619 (1-(2-(p-toluidino)-5-nitrophenylsulfonyl)-3-tert-b...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	319	n/a	n/a	n/a	n/a	n/a	n/a
University of Liège Curated by ChEMBL					Assay Description Antagonist activity at human thromboxane A2 receptor isoform alpha expressed in HEK293 cells assessed as inhibition of U46619-induced calcium mobiliz...				J Med Chem 50: 3928-36 (2007) Article DOI: 10.1021/jm070427h BindingDB Entry DOI: 10.7270/Q2RB7497
University of Liège Curated by ChEMBL					More data for this Ligand-Target Pair
Thromboxane A2 receptor (Homo sapiens (Human))	BDBM50188619 (1-(2-(p-toluidino)-5-nitrophenylsulfonyl)-3-tert-b...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	620	n/a	n/a	n/a	n/a	n/a	n/a
University of Liege Curated by ChEMBL					Assay Description Antagonist activity at human thromboxane A2 receptor beta over-expressed in HEK293 cells assessed as inhibition of U-46619-induced intracellular calc...				Eur J Med Chem 65: 32-40 (2013) Article DOI: 10.1016/j.ejmech.2013.04.033 BindingDB Entry DOI: 10.7270/Q2W95BMW
University of Liege Curated by ChEMBL					More data for this Ligand-Target Pair
Thromboxane A2 receptor (Homo sapiens (Human))	BDBM50188619 (1-(2-(p-toluidino)-5-nitrophenylsulfonyl)-3-tert-b...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
University of Liege Curated by ChEMBL					Assay Description Antagonist activity at human thromboxane A2 receptor alpha over-expressed in HEK293 cells assessed as inhibition of U-46619-induced intracellular cal...				Eur J Med Chem 65: 32-40 (2013) Article DOI: 10.1016/j.ejmech.2013.04.033 BindingDB Entry DOI: 10.7270/Q2W95BMW
University of Liege Curated by ChEMBL					More data for this Ligand-Target Pair