BindingDB PrimarySearch

Found 24 hits Enz. Inhib. hit(s) with Target = 'Translocator protein' and Ligand = 'BDBM22040'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Translocator protein (Rattus norvegicus (rat))	BDBM22040 (4 -chlorodiazepam \| 4' Cl-diazepam \| 7-chloro-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	6.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Dainippon Sumitomo Pharma Co., Ltd Curated by ChEMBL					Assay Description Displacement of [3H]PK11195 from TSPO receptor in rat Sprague-Dawley kidney membranes after 1 hr by liquid scintillation counting				Bioorg Med Chem 20: 5568-82 (2012) Article DOI: 10.1016/j.bmc.2012.07.023 BindingDB Entry DOI: 10.7270/Q2DF6SGW
Dainippon Sumitomo Pharma Co., Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Translocator protein (Rattus norvegicus (rat))	BDBM22040 (4 -chlorodiazepam \| 4' Cl-diazepam \| 7-chloro-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	7.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Medical Center Curated by ChEMBL					Assay Description Binding affinity for peripheral benzodiazepine receptor of rat kidney				J Med Chem 31: 2081-6 (1988) BindingDB Entry DOI: 10.7270/Q2BK1BBK
University of Michigan Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Translocator protein (Rattus norvegicus (rat))	BDBM22040 (4 -chlorodiazepam \| 4' Cl-diazepam \| 7-chloro-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	23	-40.5	n/a	n/a	n/a	n/a	n/a	7.4	4
Universita di Pisa					Assay Description Assays were performed by incubating aliquots of rat kidney mitochondria suspensions with [3H]PK 11195 and a range of concentrations of the test compo...				J Med Chem 50: 404-7 (2007) Article DOI: 10.1021/jm061137o BindingDB Entry DOI: 10.7270/Q23J3B8X
Universita di Pisa					More data for this Ligand-Target Pair
Translocator protein (Rattus norvegicus (rat))	BDBM22040 (4 -chlorodiazepam \| 4' Cl-diazepam \| 7-chloro-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	23	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01808 BindingDB Entry DOI: 10.7270/Q2SF316G
TBA					More data for this Ligand-Target Pair
Translocator protein (Rattus norvegicus (rat))	BDBM22040 (4 -chlorodiazepam \| 4' Cl-diazepam \| 7-chloro-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	23	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Napoli Federico II Curated by ChEMBL					Assay Description Displacement of [3H]PK11195 from TSPO receptor in rat kidney membranes				Eur J Med Chem 46: 4506-20 (2011) Article DOI: 10.1016/j.ejmech.2011.07.025 BindingDB Entry DOI: 10.7270/Q26D5V0V
Universit£ di Napoli Federico II Curated by ChEMBL					More data for this Ligand-Target Pair
Translocator protein (Rattus norvegicus (rat))	BDBM22040 (4 -chlorodiazepam \| 4' Cl-diazepam \| 7-chloro-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	23	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Salerno Curated by ChEMBL					Assay Description Displacement of [3H]PK11195 from TSPO in rat kidney mitochondrial membranes by competitive binding assay				J Med Chem 55: 4506-10 (2012) Article DOI: 10.1021/jm201703k BindingDB Entry DOI: 10.7270/Q2TB1806
Universit£ di Salerno Curated by ChEMBL					More data for this Ligand-Target Pair
Translocator protein (Rattus norvegicus (rat))	BDBM22040 (4 -chlorodiazepam \| 4' Cl-diazepam \| 7-chloro-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	23	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Displacement of [11C]PK11195 from TSPO in rat kidney mitochondrial membrane				J Med Chem 54: 366-73 (2011) Article DOI: 10.1021/jm101230g BindingDB Entry DOI: 10.7270/Q2ZC83T4
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Translocator protein (Rattus norvegicus (rat))	BDBM22040 (4 -chlorodiazepam \| 4' Cl-diazepam \| 7-chloro-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	23	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Pisa Curated by ChEMBL					Assay Description Displacement of [3H]PK11195 from translocator protein in rat kidney mitochondrial membrane				J Med Chem 51: 5798-806 (2008) Article DOI: 10.1021/jm8003224 BindingDB Entry DOI: 10.7270/Q2GF0VD5
Universit£ di Pisa Curated by ChEMBL					More data for this Ligand-Target Pair
Translocator protein (Rattus norvegicus (rat))	BDBM22040 (4 -chlorodiazepam \| 4' Cl-diazepam \| 7-chloro-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	23	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Pisa Curated by ChEMBL					Assay Description Binding affinity to peripheral benzodiazepine receptors using [3H]-PK11195 radioligand in rat kidney mitochondrial membrane				J Med Chem 47: 1852-5 (2004) Article DOI: 10.1021/jm030973k BindingDB Entry DOI: 10.7270/Q2WQ04K6
Universit£ di Pisa Curated by ChEMBL					More data for this Ligand-Target Pair
Translocator protein (Rattus norvegicus (rat))	BDBM22040 (4 -chlorodiazepam \| 4' Cl-diazepam \| 7-chloro-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	23	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Pisa Curated by ChEMBL					Assay Description Displacement of [3H]Ro5-4864 from TSPO in rat kidney mitochondrial membrane				J Med Chem 53: 4085-93 (2010) Article DOI: 10.1021/jm100100q BindingDB Entry DOI: 10.7270/Q2XG9R9C
Universit£ di Pisa Curated by ChEMBL					More data for this Ligand-Target Pair
Translocator protein (Rattus norvegicus (rat))	BDBM22040 (4 -chlorodiazepam \| 4' Cl-diazepam \| 7-chloro-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	23	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Pisa Curated by ChEMBL					Assay Description Inhibition of [3H]PK11195 binding to TSPO in rat kidney mitochondrial membranes				J Med Chem 58: 6081-92 (2015) Article DOI: 10.1021/acs.jmedchem.5b00689 BindingDB Entry DOI: 10.7270/Q20003WH
Universit£ di Pisa Curated by ChEMBL					More data for this Ligand-Target Pair
Translocator protein (Rattus norvegicus (rat))	BDBM22040 (4 -chlorodiazepam \| 4' Cl-diazepam \| 7-chloro-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	23	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Salerno Curated by ChEMBL					Assay Description Displacement of [3H]PK11195 from TSPO in rat kidney mitochondrial membranes				J Med Chem 57: 2413-28 (2014) Article DOI: 10.1021/jm401721h BindingDB Entry DOI: 10.7270/Q2416ZKP
Universit£ di Salerno Curated by ChEMBL					More data for this Ligand-Target Pair
Translocator protein (Rattus norvegicus (rat))	BDBM22040 (4 -chlorodiazepam \| 4' Cl-diazepam \| 7-chloro-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	34	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Curated by ChEMBL					Assay Description Displacement of [3H]PK11195 from PBR in rat kidney mitochondrial membrane				Bioorg Med Chem 16: 6145-55 (2008) Article DOI: 10.1016/j.bmc.2008.04.046 BindingDB Entry DOI: 10.7270/Q26Q1Z4G
Emory University Curated by ChEMBL					More data for this Ligand-Target Pair
Translocator protein (Rattus norvegicus (rat))	BDBM22040 (4 -chlorodiazepam \| 4' Cl-diazepam \| 7-chloro-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Pharmacia & Upjohn Curated by ChEMBL					Assay Description Displacement of [3H]-PK11195 binding from peripheral benzodiazepine receptor in C6 rat glioma cell line				J Med Chem 39: 2435-7 (1996) Article DOI: 10.1021/jm960084f BindingDB Entry DOI: 10.7270/Q2H1314Z
Pharmacia & Upjohn Curated by ChEMBL					More data for this Ligand-Target Pair
Translocator protein (Mus musculus)	BDBM22040 (4 -chlorodiazepam \| 4' Cl-diazepam \| 7-chloro-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Pharmacia & Upjohn Curated by ChEMBL					Assay Description Displacement of [3H]-PK11195 binding from peripheral benzodiazepine receptor in MA-10 mouse tumor Leydig cells				J Med Chem 39: 2435-7 (1996) Article DOI: 10.1021/jm960084f BindingDB Entry DOI: 10.7270/Q2H1314Z
Pharmacia & Upjohn Curated by ChEMBL					More data for this Ligand-Target Pair
Translocator protein (Rattus norvegicus (rat))	BDBM22040 (4 -chlorodiazepam \| 4' Cl-diazepam \| 7-chloro-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Korea Institute of Science and Technology (KIST) Curated by ChEMBL					Assay Description Displacement of [3H]PK11195 from TSPO in Sprague-Dawley rat cerebral cortex membranes after 60 mins by liquid scintillation counting analysis				Eur J Med Chem 141: 240-256 (2017) Article DOI: 10.1016/j.ejmech.2017.09.033 BindingDB Entry DOI: 10.7270/Q2ZG6VRM
					More data for this Ligand-Target Pair
Translocator protein (Rattus norvegicus (rat))	BDBM22040 (4 -chlorodiazepam \| 4' Cl-diazepam \| 7-chloro-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	58	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Siena Curated by ChEMBL					Assay Description Displacement of [3H]-PK 11195 from peripheral (mitochondrial) benzodiazepine receptor				J Med Chem 37: 1427-38 (1994) BindingDB Entry DOI: 10.7270/Q2668DVR
Universit£ di Siena Curated by ChEMBL					More data for this Ligand-Target Pair
Translocator protein (Homo sapiens (Human))	BDBM22040 (4 -chlorodiazepam \| 4' Cl-diazepam \| 7-chloro-...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a
Emory University Curated by ChEMBL					Assay Description Binding affinity to human PBR				Bioorg Med Chem 16: 6145-55 (2008) Article DOI: 10.1016/j.bmc.2008.04.046 BindingDB Entry DOI: 10.7270/Q26Q1Z4G
Emory University Curated by ChEMBL					More data for this Ligand-Target Pair
Translocator protein (Rattus norvegicus (rat))	BDBM22040 (4 -chlorodiazepam \| 4' Cl-diazepam \| 7-chloro-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description Binding affinity constant for Benzodiazepine receptor in normal rat brain homogenate				J Med Chem 40: 1726-30 (1997) Article DOI: 10.1021/jm960592p BindingDB Entry DOI: 10.7270/Q2X929DZ
University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair
Translocator protein (Rattus norvegicus (rat))	BDBM22040 (4 -chlorodiazepam \| 4' Cl-diazepam \| 7-chloro-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description Binding affinity constant for Benzodiazepine receptor in rat C6 glioma cells				J Med Chem 40: 1726-30 (1997) Article DOI: 10.1021/jm960592p BindingDB Entry DOI: 10.7270/Q2X929DZ
University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair
Translocator protein (Rattus norvegicus (rat))	BDBM22040 (4 -chlorodiazepam \| 4' Cl-diazepam \| 7-chloro-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	58	n/a	n/a	n/a	n/a	n/a
Universit£ di Ferrara Curated by ChEMBL					Assay Description Binding affinity constant for peripheral (mitochondrial) Benzodiazepine receptor				J Med Chem 38: 4730-8 (1995) BindingDB Entry DOI: 10.7270/Q2ZW1MJ8
Universit£ di Ferrara Curated by ChEMBL					More data for this Ligand-Target Pair
Translocator protein (Rattus norvegicus (rat))	BDBM22040 (4 -chlorodiazepam \| 4' Cl-diazepam \| 7-chloro-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description Binding affinity constant for Benzodiazepine receptor in rat RG-2 glioma cells				J Med Chem 40: 1726-30 (1997) Article DOI: 10.1021/jm960592p BindingDB Entry DOI: 10.7270/Q2X929DZ
University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair
Translocator protein (Homo sapiens (Human))	BDBM22040 (4 -chlorodiazepam \| 4' Cl-diazepam \| 7-chloro-...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars		n/a	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitory activity against Dihydrofolate reductase of Escherichia coli				Citation and Details
TBA					More data for this Ligand-Target Pair
Translocator protein (Rattus norvegicus (rat))	BDBM22040 (4 -chlorodiazepam \| 4' Cl-diazepam \| 7-chloro-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a
Brain and Mind Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]Ro5-4864 from TSPO in rat kainate lesioned striatum				J Med Chem 52: 581-92 (2009) Article DOI: 10.1021/jm8011678 BindingDB Entry DOI: 10.7270/Q2222VP0
Brain and Mind Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair