Found 40 hits for monomerid = 22040 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Gamma-aminobutyric acid receptor subunit alpha-1
(Rattus norvegicus (Rat)) | BDBM22040
(4 -chlorodiazepam | 4' Cl-diazepam | 7-chloro-...)Show SMILES CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccc(Cl)cc1 |c:10| Show InChI InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3 | PDB
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| 0.410 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tokyo Dental College
Curated by PDSP Ki Database
| |
Biochem Pharmacol 55: 209-14 (1998)
Article DOI: 10.1016/s0006-2952(97)00433-4 BindingDB Entry DOI: 10.7270/Q2NP22ZJ |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1
(Rattus norvegicus (Rat)) | BDBM22040
(4 -chlorodiazepam | 4' Cl-diazepam | 7-chloro-...)Show SMILES CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccc(Cl)cc1 |c:10| Show InChI InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3 | PDB
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| 1.24 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tokyo Dental College
Curated by PDSP Ki Database
| |
Biochem Pharmacol 55: 209-14 (1998)
Article DOI: 10.1016/s0006-2952(97)00433-4 BindingDB Entry DOI: 10.7270/Q2NP22ZJ |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1
(Rattus norvegicus (Rat)) | BDBM22040
(4 -chlorodiazepam | 4' Cl-diazepam | 7-chloro-...)Show SMILES CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccc(Cl)cc1 |c:10| Show InChI InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3 | PDB
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| 4.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by PDSP Ki Database
| |
Proc Natl Acad Sci U S A 74: 3805-9 (1977)
Article DOI: 10.1073/pnas.74.9.3805 BindingDB Entry DOI: 10.7270/Q2Q23XR0 |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1
(Rattus norvegicus (Rat)) | BDBM22040
(4 -chlorodiazepam | 4' Cl-diazepam | 7-chloro-...)Show SMILES CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccc(Cl)cc1 |c:10| Show InChI InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3 | PDB
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| 4.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by PDSP Ki Database
| |
Proc Natl Acad Sci U S A 74: 3805-9 (1977)
Article DOI: 10.1073/pnas.74.9.3805 BindingDB Entry DOI: 10.7270/Q2Q23XR0 |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1
(Rattus norvegicus (Rat)) | BDBM22040
(4 -chlorodiazepam | 4' Cl-diazepam | 7-chloro-...)Show SMILES CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccc(Cl)cc1 |c:10| Show InChI InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3 | PDB
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| 4.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by PDSP Ki Database
| |
Proc Natl Acad Sci U S A 74: 3805-9 (1977)
Article DOI: 10.1073/pnas.74.9.3805 BindingDB Entry DOI: 10.7270/Q2Q23XR0 |
More data for this Ligand-Target Pair | |
Peripheral-Type Benzodiazepine Receptor
(Rattus norvegicus (rat)) | BDBM22040
(4 -chlorodiazepam | 4' Cl-diazepam | 7-chloro-...)Show SMILES CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccc(Cl)cc1 |c:10| Show InChI InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3 | PDB
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| 6.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Sumitomo Pharma Co., Ltd
Curated by ChEMBL
| Assay Description Displacement of [3H]PK11195 from TSPO receptor in rat Sprague-Dawley kidney membranes after 1 hr by liquid scintillation counting |
Bioorg Med Chem 20: 5568-82 (2012)
Article DOI: 10.1016/j.bmc.2012.07.023 BindingDB Entry DOI: 10.7270/Q2DF6SGW |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1
(Rattus norvegicus (Rat)) | BDBM22040
(4 -chlorodiazepam | 4' Cl-diazepam | 7-chloro-...)Show SMILES CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccc(Cl)cc1 |c:10| Show InChI InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3 | PDB
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| 7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Technion-Israel Institute of Technology
Curated by PDSP Ki Database
| |
Life Sci 49: 1155-61 (1991)
Article DOI: 10.1016/0024-3205(91)90562-p BindingDB Entry DOI: 10.7270/Q2319TC5 |
More data for this Ligand-Target Pair | |
Peripheral-Type Benzodiazepine Receptor
(Rattus norvegicus (rat)) | BDBM22040
(4 -chlorodiazepam | 4' Cl-diazepam | 7-chloro-...)Show SMILES CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccc(Cl)cc1 |c:10| Show InChI InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3 | PDB
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| 7.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Medical Center
Curated by ChEMBL
| Assay Description Binding affinity for peripheral benzodiazepine receptor of rat kidney |
J Med Chem 31: 2081-6 (1988)
BindingDB Entry DOI: 10.7270/Q2BK1BBK |
More data for this Ligand-Target Pair | |
Peripheral-Type Benzodiazepine Receptor
(Rattus norvegicus (rat)) | BDBM22040
(4 -chlorodiazepam | 4' Cl-diazepam | 7-chloro-...)Show SMILES CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccc(Cl)cc1 |c:10| Show InChI InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3 | PDB
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| 23 | -9.68 | n/a | n/a | n/a | n/a | n/a | 7.4 | 4 |
Universita di Pisa
| Assay Description Assays were performed by incubating aliquots of rat kidney mitochondria suspensions with [3H]PK 11195 and a range of concentrations of the test compo... |
J Med Chem 50: 404-7 (2007)
Article DOI: 10.1021/jm061137o BindingDB Entry DOI: 10.7270/Q23J3B8X |
More data for this Ligand-Target Pair | |
Peripheral-Type Benzodiazepine Receptor
(Rattus norvegicus (rat)) | BDBM22040
(4 -chlorodiazepam | 4' Cl-diazepam | 7-chloro-...)Show SMILES CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccc(Cl)cc1 |c:10| Show InChI InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3 | PDB
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| 23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Napoli Federico II
Curated by ChEMBL
| Assay Description Displacement of [3H]PK11195 from TSPO receptor in rat kidney membranes |
Eur J Med Chem 46: 4506-20 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.025 BindingDB Entry DOI: 10.7270/Q26D5V0V |
More data for this Ligand-Target Pair | |
Peripheral-Type Benzodiazepine Receptor
(Rattus norvegicus (rat)) | BDBM22040
(4 -chlorodiazepam | 4' Cl-diazepam | 7-chloro-...)Show SMILES CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccc(Cl)cc1 |c:10| Show InChI InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3 | PDB
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| 23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Salerno
Curated by ChEMBL
| Assay Description Displacement of [3H]PK11195 from TSPO in rat kidney mitochondrial membranes by competitive binding assay |
J Med Chem 55: 4506-10 (2012)
Article DOI: 10.1021/jm201703k BindingDB Entry DOI: 10.7270/Q2TB1806 |
More data for this Ligand-Target Pair | |
Peripheral-Type Benzodiazepine Receptor
(Rattus norvegicus (rat)) | BDBM22040
(4 -chlorodiazepam | 4' Cl-diazepam | 7-chloro-...)Show SMILES CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccc(Cl)cc1 |c:10| Show InChI InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3 | PDB
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| 23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health
Curated by ChEMBL
| Assay Description Displacement of [11C]PK11195 from TSPO in rat kidney mitochondrial membrane |
J Med Chem 54: 366-73 (2011)
Article DOI: 10.1021/jm101230g BindingDB Entry DOI: 10.7270/Q2ZC83T4 |
More data for this Ligand-Target Pair | |
Peripheral-Type Benzodiazepine Receptor
(Rattus norvegicus (rat)) | BDBM22040
(4 -chlorodiazepam | 4' Cl-diazepam | 7-chloro-...)Show SMILES CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccc(Cl)cc1 |c:10| Show InChI InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3 | PDB
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| 23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa
Curated by ChEMBL
| Assay Description Displacement of [3H]PK11195 from translocator protein in rat kidney mitochondrial membrane |
J Med Chem 51: 5798-806 (2008)
Article DOI: 10.1021/jm8003224 BindingDB Entry DOI: 10.7270/Q2GF0VD5 |
More data for this Ligand-Target Pair | |
Peripheral-Type Benzodiazepine Receptor
(Rattus norvegicus (rat)) | BDBM22040
(4 -chlorodiazepam | 4' Cl-diazepam | 7-chloro-...)Show SMILES CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccc(Cl)cc1 |c:10| Show InChI InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3 | PDB
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| 23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa
Curated by ChEMBL
| Assay Description Binding affinity to peripheral benzodiazepine receptors using [3H]-PK11195 radioligand in rat kidney mitochondrial membrane |
J Med Chem 47: 1852-5 (2004)
Article DOI: 10.1021/jm030973k BindingDB Entry DOI: 10.7270/Q2WQ04K6 |
More data for this Ligand-Target Pair | |
Peripheral-Type Benzodiazepine Receptor
(Rattus norvegicus (rat)) | BDBM22040
(4 -chlorodiazepam | 4' Cl-diazepam | 7-chloro-...)Show SMILES CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccc(Cl)cc1 |c:10| Show InChI InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3 | PDB
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| 23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa
Curated by ChEMBL
| Assay Description Displacement of [3H]Ro5-4864 from TSPO in rat kidney mitochondrial membrane |
J Med Chem 53: 4085-93 (2010)
Article DOI: 10.1021/jm100100q BindingDB Entry DOI: 10.7270/Q2XG9R9C |
More data for this Ligand-Target Pair | |
Peripheral-Type Benzodiazepine Receptor
(Rattus norvegicus (rat)) | BDBM22040
(4 -chlorodiazepam | 4' Cl-diazepam | 7-chloro-...)Show SMILES CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccc(Cl)cc1 |c:10| Show InChI InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3 | PDB
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| 23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa
Curated by ChEMBL
| Assay Description Inhibition of [3H]PK11195 binding to TSPO in rat kidney mitochondrial membranes |
J Med Chem 58: 6081-92 (2015)
BindingDB Entry DOI: 10.7270/Q20003WH |
More data for this Ligand-Target Pair | |
Peripheral-Type Benzodiazepine Receptor
(Rattus norvegicus (rat)) | BDBM22040
(4 -chlorodiazepam | 4' Cl-diazepam | 7-chloro-...)Show SMILES CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccc(Cl)cc1 |c:10| Show InChI InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3 | PDB
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| 23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Salerno
Curated by ChEMBL
| Assay Description Displacement of [3H]PK11195 from TSPO in rat kidney mitochondrial membranes |
J Med Chem 57: 2413-28 (2014)
Article DOI: 10.1021/jm401721h BindingDB Entry DOI: 10.7270/Q2416ZKP |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1
(Rattus norvegicus (Rat)) | BDBM22040
(4 -chlorodiazepam | 4' Cl-diazepam | 7-chloro-...)Show SMILES CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccc(Cl)cc1 |c:10| Show InChI InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3 | PDB
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| 27 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Technion-Israel Institute of Technology
Curated by PDSP Ki Database
| |
Life Sci 49: 1155-61 (1991)
Article DOI: 10.1016/0024-3205(91)90562-p BindingDB Entry DOI: 10.7270/Q2319TC5 |
More data for this Ligand-Target Pair | |
Peripheral-Type Benzodiazepine Receptor
(Rattus norvegicus (rat)) | BDBM22040
(4 -chlorodiazepam | 4' Cl-diazepam | 7-chloro-...)Show SMILES CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccc(Cl)cc1 |c:10| Show InChI InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3 | PDB
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| 34 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University
Curated by ChEMBL
| Assay Description Displacement of [3H]PK11195 from PBR in rat kidney mitochondrial membrane |
Bioorg Med Chem 16: 6145-55 (2008)
Article DOI: 10.1016/j.bmc.2008.04.046 BindingDB Entry DOI: 10.7270/Q26Q1Z4G |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1
(Homo sapiens (Human)) | BDBM22040
(4 -chlorodiazepam | 4' Cl-diazepam | 7-chloro-...)Show SMILES CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccc(Cl)cc1 |c:10| Show InChI InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3 | PDB
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| 750 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Technion-Israel Institute of Technology
Curated by PDSP Ki Database
| |
Life Sci 49: 1155-61 (1991)
Article DOI: 10.1016/0024-3205(91)90562-p BindingDB Entry DOI: 10.7270/Q2319TC5 |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1
(Homo sapiens (Human)) | BDBM22040
(4 -chlorodiazepam | 4' Cl-diazepam | 7-chloro-...)Show SMILES CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccc(Cl)cc1 |c:10| Show InChI InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3 | PDB
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| 750 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Technion-Israel Institute of Technology
Curated by PDSP Ki Database
| |
Life Sci 49: 1155-61 (1991)
Article DOI: 10.1016/0024-3205(91)90562-p BindingDB Entry DOI: 10.7270/Q2319TC5 |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1
(Homo sapiens (Human)) | BDBM22040
(4 -chlorodiazepam | 4' Cl-diazepam | 7-chloro-...)Show SMILES CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccc(Cl)cc1 |c:10| Show InChI InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3 | PDB
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| Article PubMed
| 750 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Technion-Israel Institute of Technology
Curated by PDSP Ki Database
| |
Life Sci 49: 1155-61 (1991)
Article DOI: 10.1016/0024-3205(91)90562-p BindingDB Entry DOI: 10.7270/Q2319TC5 |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid type B receptor subunit 1
(Rattus norvegicus (Rat)) | BDBM22040
(4 -chlorodiazepam | 4' Cl-diazepam | 7-chloro-...)Show SMILES CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccc(Cl)cc1 |c:10| Show InChI InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3 | PDB
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| 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Georgetown University
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 256: 1154-60 (1991)
BindingDB Entry DOI: 10.7270/Q2125R4D |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid type B receptor subunit 1
(Rattus norvegicus (Rat)) | BDBM22040
(4 -chlorodiazepam | 4' Cl-diazepam | 7-chloro-...)Show SMILES CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccc(Cl)cc1 |c:10| Show InChI InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3 | PDB
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| 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Georgetown University
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 256: 1154-60 (1991)
BindingDB Entry DOI: 10.7270/Q2125R4D |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid type B receptor subunit 1
(Rattus norvegicus (Rat)) | BDBM22040
(4 -chlorodiazepam | 4' Cl-diazepam | 7-chloro-...)Show SMILES CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccc(Cl)cc1 |c:10| Show InChI InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3 | PDB
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| 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Georgetown University
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 256: 1154-60 (1991)
BindingDB Entry DOI: 10.7270/Q2125R4D |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1
(Rattus norvegicus (Rat)) | BDBM22040
(4 -chlorodiazepam | 4' Cl-diazepam | 7-chloro-...)Show SMILES CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccc(Cl)cc1 |c:10| Show InChI InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3 | PDB
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| Article PubMed
| 9.85E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Technion-Israel Institute of Technology
Curated by PDSP Ki Database
| |
Life Sci 49: 1155-61 (1991)
Article DOI: 10.1016/0024-3205(91)90562-p BindingDB Entry DOI: 10.7270/Q2319TC5 |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1
(Rattus norvegicus (Rat)) | BDBM22040
(4 -chlorodiazepam | 4' Cl-diazepam | 7-chloro-...)Show SMILES CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccc(Cl)cc1 |c:10| Show InChI InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3 | PDB
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| 9.86E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Technion-Israel Institute of Technology
Curated by PDSP Ki Database
| |
Life Sci 49: 1155-61 (1991)
Article DOI: 10.1016/0024-3205(91)90562-p BindingDB Entry DOI: 10.7270/Q2319TC5 |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1
(Rattus norvegicus (Rat)) | BDBM22040
(4 -chlorodiazepam | 4' Cl-diazepam | 7-chloro-...)Show SMILES CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccc(Cl)cc1 |c:10| Show InChI InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3 | PDB
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by PDSP Ki Database
| |
Proc Natl Acad Sci U S A 74: 3805-9 (1977)
Article DOI: 10.1073/pnas.74.9.3805 BindingDB Entry DOI: 10.7270/Q2Q23XR0 |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1
(Rattus norvegicus (Rat)) | BDBM22040
(4 -chlorodiazepam | 4' Cl-diazepam | 7-chloro-...)Show SMILES CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccc(Cl)cc1 |c:10| Show InChI InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3 | PDB
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tokyo Dental College
Curated by PDSP Ki Database
| |
Biochem Pharmacol 55: 209-14 (1998)
Article DOI: 10.1016/s0006-2952(97)00433-4 BindingDB Entry DOI: 10.7270/Q2NP22ZJ |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1
(Rattus norvegicus (Rat)) | BDBM22040
(4 -chlorodiazepam | 4' Cl-diazepam | 7-chloro-...)Show SMILES CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccc(Cl)cc1 |c:10| Show InChI InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3 | PDB
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tokyo Dental College
Curated by PDSP Ki Database
| |
Biochem Pharmacol 55: 209-14 (1998)
Article DOI: 10.1016/s0006-2952(97)00433-4 BindingDB Entry DOI: 10.7270/Q2NP22ZJ |
More data for this Ligand-Target Pair | |
Peripheral-Type Benzodiazepine Receptor
(Rattus norvegicus (rat)) | BDBM22040
(4 -chlorodiazepam | 4' Cl-diazepam | 7-chloro-...)Show SMILES CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccc(Cl)cc1 |c:10| Show InChI InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3 | PDB
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| n/a | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a |
Brain and Mind Research Institute
Curated by ChEMBL
| Assay Description Displacement of [3H]Ro5-4864 from TSPO in rat kainate lesioned striatum |
J Med Chem 52: 581-92 (2009)
Article DOI: 10.1021/jm8011678 BindingDB Entry DOI: 10.7270/Q2222VP0 |
More data for this Ligand-Target Pair | |
Peripheral-Type Benzodiazepine Receptor
(Rattus norvegicus (rat)) | BDBM22040
(4 -chlorodiazepam | 4' Cl-diazepam | 7-chloro-...)Show SMILES CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccc(Cl)cc1 |c:10| Show InChI InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3 | PDB
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| n/a | n/a | 58 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Siena
Curated by ChEMBL
| Assay Description Displacement of [3H]-PK 11195 from peripheral (mitochondrial) benzodiazepine receptor |
J Med Chem 37: 1427-38 (1994)
BindingDB Entry DOI: 10.7270/Q2668DVR |
More data for this Ligand-Target Pair | |
Translocator protein
(Homo sapiens (Human)) | BDBM22040
(4 -chlorodiazepam | 4' Cl-diazepam | 7-chloro-...)Show SMILES CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccc(Cl)cc1 |c:10| Show InChI InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3 | KEGG
UniProtKB/SwissProt
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| n/a | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a |
Emory University
Curated by ChEMBL
| Assay Description Binding affinity to human PBR |
Bioorg Med Chem 16: 6145-55 (2008)
Article DOI: 10.1016/j.bmc.2008.04.046 BindingDB Entry DOI: 10.7270/Q26Q1Z4G |
More data for this Ligand-Target Pair | |
Peripheral-Type Benzodiazepine Receptor
(Rattus norvegicus (rat)) | BDBM22040
(4 -chlorodiazepam | 4' Cl-diazepam | 7-chloro-...)Show SMILES CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccc(Cl)cc1 |c:10| Show InChI InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3 | PDB
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| n/a | n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by ChEMBL
| Assay Description Binding affinity constant for Benzodiazepine receptor in normal rat brain homogenate |
J Med Chem 40: 1726-30 (1997)
Article DOI: 10.1021/jm960592p BindingDB Entry DOI: 10.7270/Q2X929DZ |
More data for this Ligand-Target Pair | |
Peripheral-Type Benzodiazepine Receptor
(Rattus norvegicus (rat)) | BDBM22040
(4 -chlorodiazepam | 4' Cl-diazepam | 7-chloro-...)Show SMILES CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccc(Cl)cc1 |c:10| Show InChI InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3 | PDB
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| n/a | n/a | n/a | 58 | n/a | n/a | n/a | n/a | n/a |
Universit£ di Ferrara
Curated by ChEMBL
| Assay Description Binding affinity constant for peripheral (mitochondrial) Benzodiazepine receptor |
J Med Chem 38: 4730-8 (1995)
BindingDB Entry DOI: 10.7270/Q2ZW1MJ8 |
More data for this Ligand-Target Pair | |
Peripheral-type benzodiazepine receptor
(Mus musculus) | BDBM22040
(4 -chlorodiazepam | 4' Cl-diazepam | 7-chloro-...)Show SMILES CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccc(Cl)cc1 |c:10| Show InChI InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3 | PDB
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| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacia & Upjohn
Curated by ChEMBL
| Assay Description Displacement of [3H]-PK11195 binding from peripheral benzodiazepine receptor in MA-10 mouse tumor Leydig cells |
J Med Chem 39: 2435-7 (1996)
Article DOI: 10.1021/jm960084f BindingDB Entry DOI: 10.7270/Q2H1314Z |
More data for this Ligand-Target Pair | |
Peripheral-Type Benzodiazepine Receptor
(Rattus norvegicus (rat)) | BDBM22040
(4 -chlorodiazepam | 4' Cl-diazepam | 7-chloro-...)Show SMILES CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccc(Cl)cc1 |c:10| Show InChI InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3 | PDB
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| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacia & Upjohn
Curated by ChEMBL
| Assay Description Displacement of [3H]-PK11195 binding from peripheral benzodiazepine receptor in C6 rat glioma cell line |
J Med Chem 39: 2435-7 (1996)
Article DOI: 10.1021/jm960084f BindingDB Entry DOI: 10.7270/Q2H1314Z |
More data for this Ligand-Target Pair | |
Peripheral-Type Benzodiazepine Receptor
(Rattus norvegicus (rat)) | BDBM22040
(4 -chlorodiazepam | 4' Cl-diazepam | 7-chloro-...)Show SMILES CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccc(Cl)cc1 |c:10| Show InChI InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3 | PDB
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| Article PubMed
| n/a | n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by ChEMBL
| Assay Description Binding affinity constant for Benzodiazepine receptor in rat C6 glioma cells |
J Med Chem 40: 1726-30 (1997)
Article DOI: 10.1021/jm960592p BindingDB Entry DOI: 10.7270/Q2X929DZ |
More data for this Ligand-Target Pair | |
Peripheral-Type Benzodiazepine Receptor
(Rattus norvegicus (rat)) | BDBM22040
(4 -chlorodiazepam | 4' Cl-diazepam | 7-chloro-...)Show SMILES CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccc(Cl)cc1 |c:10| Show InChI InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3 | PDB
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| Article PubMed
| n/a | n/a | n/a | 3.5 | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by ChEMBL
| Assay Description Binding affinity constant for Benzodiazepine receptor in rat RG-2 glioma cells |
J Med Chem 40: 1726-30 (1997)
Article DOI: 10.1021/jm960592p BindingDB Entry DOI: 10.7270/Q2X929DZ |
More data for this Ligand-Target Pair | |
Benzodiazepine receptors; peripheral & central
(Rattus norvegicus (rat)) | BDBM22040
(4 -chlorodiazepam | 4' Cl-diazepam | 7-chloro-...)Show SMILES CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccc(Cl)cc1 |c:10| Show InChI InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3 | PDB
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| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Institute of Science and Technology (KIST)
Curated by ChEMBL
| Assay Description Displacement of [3H]PK11195 from TSPO in Sprague-Dawley rat cerebral cortex membranes after 60 mins by liquid scintillation counting analysis |
Eur J Med Chem 141: 240-256 (2017)
Article DOI: 10.1016/j.ejmech.2017.09.033 BindingDB Entry DOI: 10.7270/Q2ZG6VRM |
More data for this Ligand-Target Pair | |