Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A' and Ligand = 'BDBM115428'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat))	BDBM115428 (US8637500, 297) Show SMILES CCOC(=O)N1CCC(CC1)c1nccnc1Oc1ccc(Nc2ccc(C)cn2)cc1 Show InChI InChI=1S/C24H27N5O3/c1-3-31-24(30)29-14-10-18(11-15-29)22-23(26-13-12-25-22)32-20-7-5-19(6-8-20)28-21-9-4-17(2)16-27-21/h4-9,12-13,16,18H,3,10-11,14-15H2,1-2H3,(H,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0560	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 μL of serial diluted PDE10A (BPS Bi...				US Patent US8637500 (2014) BindingDB Entry DOI: 10.7270/Q2XP73MV
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