Compile Data Set for Download or QSAR

Found 5 hits Enz. Inhib. hit(s) with Target = 'cGMP-specific 3',5'-cyclic phosphodiesterase' and Ligand = 'BDBM50020874'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50020874 ((3-Chloro-phenyl)-(4-phenyl-phthalazin-1-yl)-amine...) Show SMILES Clc1cccc(Nc2nnc(-c3ccccc3)c3ccccc23)c1 Show InChI InChI=1S/C20H14ClN3/c21-15-9-6-10-16(13-15)22-20-18-12-5-4-11-17(18)19(23-24-20)14-7-2-1-3-8-14/h1-13H,(H,22,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
SmithKline Beecham Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of phosphodiesterase 5A				J Med Chem 37: 476-85 (1994) BindingDB Entry DOI: 10.7270/Q2P26X6N
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50020874 ((3-Chloro-phenyl)-(4-phenyl-phthalazin-1-yl)-amine...) Show SMILES Clc1cccc(Nc2nnc(-c3ccccc3)c3ccccc23)c1 Show InChI InChI=1S/C20H14ClN3/c21-15-9-6-10-16(13-15)22-20-18-12-5-4-11-17(18)19(23-24-20)14-7-2-1-3-8-14/h1-13H,(H,22,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ de Strasbourg Curated by ChEMBL					Assay Description Inhibition of PDE5 (unknown origin) using 0.4 uM cGMP as substrate				Eur J Med Chem 177: 269-290 (2019) Article DOI: 10.1016/j.ejmech.2019.05.026 BindingDB Entry DOI: 10.7270/Q2C250W8
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50020874 ((3-Chloro-phenyl)-(4-phenyl-phthalazin-1-yl)-amine...) Show SMILES Clc1cccc(Nc2nnc(-c3ccccc3)c3ccccc23)c1 Show InChI InChI=1S/C20H14ClN3/c21-15-9-6-10-16(13-15)22-20-18-12-5-4-11-17(18)19(23-24-20)14-7-2-1-3-8-14/h1-13H,(H,22,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co. Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against cyclic GMP-phosphodiesterase (PDE V) isolated from porcine aorta.				J Med Chem 36: 3765-70 (1994) BindingDB Entry DOI: 10.7270/Q279459H
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50020874 ((3-Chloro-phenyl)-(4-phenyl-phthalazin-1-yl)-amine...) Show SMILES Clc1cccc(Nc2nnc(-c3ccccc3)c3ccccc23)c1 Show InChI InChI=1S/C20H14ClN3/c21-15-9-6-10-16(13-15)22-20-18-12-5-4-11-17(18)19(23-24-20)14-7-2-1-3-8-14/h1-13H,(H,22,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Biofor Inc. Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase 5 from human platelets				J Med Chem 38: 3547-57 (1995) BindingDB Entry DOI: 10.7270/Q2F190CB
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Bos taurus)	BDBM50020874 ((3-Chloro-phenyl)-(4-phenyl-phthalazin-1-yl)-amine...) Show SMILES Clc1cccc(Nc2nnc(-c3ccccc3)c3ccccc23)c1 Show InChI InChI=1S/C20H14ClN3/c21-15-9-6-10-16(13-15)22-20-18-12-5-4-11-17(18)19(23-24-20)14-7-2-1-3-8-14/h1-13H,(H,22,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ de Strasbourg Curated by ChEMBL					Assay Description Inhibition of bovine aortic smooth muscle PDE5 using cGMP as substrate incubated for 30 mins in presence of EGTA and [3H]cGMP by liquid scintillation...				Eur J Med Chem 177: 269-290 (2019) Article DOI: 10.1016/j.ejmech.2019.05.026 BindingDB Entry DOI: 10.7270/Q2C250W8
					More data for this Ligand-Target Pair