BDBM50020874 (3-Chloro-phenyl)-(4-phenyl-phthalazin-1-yl)-amine::CHEMBL332898
SMILES: Clc1cccc(Nc2nnc(-c3ccccc3)c3ccccc23)c1
InChI Key: InChIKey=CEHQLKSLMFIHBF-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Phosphodiesterase 1 (Homo sapiens (Human)) | BDBM50020874 ((3-Chloro-phenyl)-(4-phenyl-phthalazin-1-yl)-amine...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 9.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Binding affinity for [Ca(2+)]/calmodulin dependent phosphodiesterase PDE 1 of human brain | J Med Chem 28: 537-45 (1985) BindingDB Entry DOI: 10.7270/Q2N58MXT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase 3 (Homo sapiens (Human)) | BDBM50020874 ((3-Chloro-phenyl)-(4-phenyl-phthalazin-1-yl)-amine...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 1.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Binding affinity for low Km cAMP phosphodiesterase PDE III of human platelets | J Med Chem 28: 537-45 (1985) BindingDB Entry DOI: 10.7270/Q2N58MXT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase 1 (Homo sapiens (Human)) | BDBM50020874 ((3-Chloro-phenyl)-(4-phenyl-phthalazin-1-yl)-amine...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co. Ltd. Curated by ChEMBL | Assay Description Inhibition of [Ca(2+)]-calmodulin-dependent cGMP-phosphodiesterase 1 from porcine coronary arteries | J Med Chem 36: 3765-70 (1994) BindingDB Entry DOI: 10.7270/Q279459H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human)) | BDBM50020874 ((3-Chloro-phenyl)-(4-phenyl-phthalazin-1-yl)-amine...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co. Ltd. Curated by ChEMBL | Assay Description Inhibitory activity against cyclic GMP-phosphodiesterase (PDE V) isolated from porcine aorta. | J Med Chem 36: 3765-70 (1994) BindingDB Entry DOI: 10.7270/Q279459H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase 3A (Sus scrofa) | BDBM50020874 ((3-Chloro-phenyl)-(4-phenyl-phthalazin-1-yl)-amine...) | PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co. Ltd. Curated by ChEMBL | Assay Description Inhibition of cGMP-inhibited phosphodiesterase from porcine coronary arteries | J Med Chem 36: 3765-70 (1994) BindingDB Entry DOI: 10.7270/Q279459H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Homo sapiens phosphodiesterase 2A (PDE2A) (Homo sapiens (Human)) | BDBM50020874 ((3-Chloro-phenyl)-(4-phenyl-phthalazin-1-yl)-amine...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Strasbourg Curated by ChEMBL | Assay Description Inhibition of human platelets PDE2 at 10 uM using cAMP as substrate incubated for 30 mins in presence of [3H]cAMP and cGMP by liquid scintillation co... | Eur J Med Chem 177: 269-290 (2019) Article DOI: 10.1016/j.ejmech.2019.05.026 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Homo sapiens phosphodiesterase 2A (PDE2A) (Homo sapiens (Human)) | BDBM50020874 ((3-Chloro-phenyl)-(4-phenyl-phthalazin-1-yl)-amine...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co. Ltd. Curated by ChEMBL | Assay Description Inhibition of cGMP-stimulated phosphodiesterase 2 of porcine coronary arteries | J Med Chem 36: 3765-70 (1994) BindingDB Entry DOI: 10.7270/Q279459H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
3',5'-cyclic phosphodiesterase (Homo sapiens (Human)) | BDBM50020874 ((3-Chloro-phenyl)-(4-phenyl-phthalazin-1-yl)-amine...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Strasbourg Curated by ChEMBL | Assay Description Inhibition of PDE5 (unknown origin) using 0.4 uM cGMP as substrate | Eur J Med Chem 177: 269-290 (2019) Article DOI: 10.1016/j.ejmech.2019.05.026 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase 5A (Bos taurus) | BDBM50020874 ((3-Chloro-phenyl)-(4-phenyl-phthalazin-1-yl)-amine...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 6.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Strasbourg Curated by ChEMBL | Assay Description Inhibition of bovine aortic smooth muscle PDE5 using cGMP as substrate incubated for 30 mins in presence of EGTA and [3H]cGMP by liquid scintillation... | Eur J Med Chem 177: 269-290 (2019) Article DOI: 10.1016/j.ejmech.2019.05.026 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human)) | BDBM50020874 ((3-Chloro-phenyl)-(4-phenyl-phthalazin-1-yl)-amine...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals Curated by ChEMBL | Assay Description Inhibition of phosphodiesterase 5A | J Med Chem 37: 476-85 (1994) BindingDB Entry DOI: 10.7270/Q2P26X6N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human)) | BDBM50020874 ((3-Chloro-phenyl)-(4-phenyl-phthalazin-1-yl)-amine...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Biofor Inc. Curated by ChEMBL | Assay Description Inhibitory activity against phosphodiesterase 5 from human platelets | J Med Chem 38: 3547-57 (1995) BindingDB Entry DOI: 10.7270/Q2F190CB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase 4A (Sus scrofa) | BDBM50020874 ((3-Chloro-phenyl)-(4-phenyl-phthalazin-1-yl)-amine...) | UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 3.72E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co. Ltd. Curated by ChEMBL | Assay Description Inhibition of cAMP specific phosphodiesterase from porcine coronary arteries | J Med Chem 36: 3765-70 (1994) BindingDB Entry DOI: 10.7270/Q279459H | |||||||||||
More data for this Ligand-Target Pair |