BindingDB PrimarySearch

Found 17 hits of ic50 for drug = Acular
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM85511 (CAS_74103-07-4 \| KETOROLAC \| Ketorolac tris salt \|...) Show SMILES OC(=O)C1CCn2c1ccc2C(=O)c1ccccc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars	DrugBank Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Faculdade de Ci�ncias e Tecnologia-UNL Curated by ChEMBL					Assay Description Inhibition of human COX2 measured after pre-incubation of enzyme with compound				J Med Chem 54: 8555-62 (2011) Article DOI: 10.1021/jm201090k BindingDB Entry DOI: 10.7270/Q2W95B6H
Faculdade de Ci�ncias e Tecnologia-UNL Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM85511 (CAS_74103-07-4 \| KETOROLAC \| Ketorolac tris salt \|...) Show SMILES OC(=O)C1CCn2c1ccc2C(=O)c1ccccc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars	DrugBank Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
Kagoshima University Curated by ChEMBL					Assay Description Inhibition of recombinant human COX2 using arachidonic acid as substrate measured after 2 to 5 mins				Eur J Med Chem 126: 270-276 (2017) Article DOI: 10.1016/j.ejmech.2016.11.038 BindingDB Entry DOI: 10.7270/Q2T72KP7
Kagoshima University Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin-H2 D-isomerase (Mus musculus)	BDBM85511 (CAS_74103-07-4 \| KETOROLAC \| Ketorolac tris salt \|...) Show SMILES OC(=O)C1CCn2c1ccc2C(=O)c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	230	n/a	n/a	n/a	n/a	n/a	n/a
Sterling Research Group Curated by ChEMBL					Assay Description Concentration required to inhibit 50% activity of prostaglandin synthetase was determined in vitro in mouse brain microsomes				J Med Chem 34: 1099-110 (1991) BindingDB Entry DOI: 10.7270/Q24M955S
Sterling Research Group Curated by ChEMBL					More data for this Ligand-Target Pair
Caspase-9 (Homo sapiens (Human))	BDBM85511 (CAS_74103-07-4 \| KETOROLAC \| Ketorolac tris salt \|...) Show SMILES OC(=O)C1CCn2c1ccc2C(=O)c1ccccc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	850	n/a	n/a	n/a	n/a	7.4	n/a
University of Colorado					Assay Description Experiments were performed in a 384-well format (Greiner no. 781207) as per the conditions noted here. Caspase-1: 2.5 nM enzyme, 6.5 mM WEHD substrat...				Cell Chem Biol 24: 281-292 (2017) Article DOI: 10.1016/j.chembiol.2017.02.003 BindingDB Entry DOI: 10.7270/Q2C53JQX
University of Colorado					More data for this Ligand-Target Pair
Caspase-4 (Homo sapiens (Human))	BDBM85511 (CAS_74103-07-4 \| KETOROLAC \| Ketorolac tris salt \|...) Show SMILES OC(=O)C1CCn2c1ccc2C(=O)c1ccccc1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	860	n/a	n/a	n/a	n/a	7.4	n/a
University of Colorado					Assay Description Experiments were performed in a 384-well format (Greiner no. 781207) as per the conditions noted here. Caspase-1: 2.5 nM enzyme, 6.5 mM WEHD substrat...				Cell Chem Biol 24: 281-292 (2017) Article DOI: 10.1016/j.chembiol.2017.02.003 BindingDB Entry DOI: 10.7270/Q2C53JQX
University of Colorado					More data for this Ligand-Target Pair
Caspase-5 (Homo sapiens (Human))	BDBM85511 (CAS_74103-07-4 \| KETOROLAC \| Ketorolac tris salt \|...) Show SMILES OC(=O)C1CCn2c1ccc2C(=O)c1ccccc1 Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	7.4	n/a
University of Colorado					Assay Description Experiments were performed in a 384-well format (Greiner no. 781207) as per the conditions noted here. Caspase-1: 2.5 nM enzyme, 6.5 mM WEHD substrat...				Cell Chem Biol 24: 281-292 (2017) Article DOI: 10.1016/j.chembiol.2017.02.003 BindingDB Entry DOI: 10.7270/Q2C53JQX
University of Colorado					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 1 (Homo sapiens (Human))	BDBM85511 (CAS_74103-07-4 \| KETOROLAC \| Ketorolac tris salt \|...) Show SMILES OC(=O)C1CCn2c1ccc2C(=O)c1ccccc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars		n/a	n/a	1.23E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Cell division control protein 42 homolog/Ras-related C3 botulinum toxin substrate 1 (Homo sapiens (Human))	BDBM85511 (CAS_74103-07-4 \| KETOROLAC \| Ketorolac tris salt \|...) Show SMILES OC(=O)C1CCn2c1ccc2C(=O)c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kagoshima University Curated by ChEMBL					Assay Description Inhibition of RAC1/CDC42 in human ovarian cancer cells				Eur J Med Chem 126: 270-276 (2017) Article DOI: 10.1016/j.ejmech.2016.11.038 BindingDB Entry DOI: 10.7270/Q2T72KP7
Kagoshima University Curated by ChEMBL					More data for this Ligand-Target Pair
Caspase-3 (Homo sapiens (Human))	BDBM85511 (CAS_74103-07-4 \| KETOROLAC \| Ketorolac tris salt \|...) Show SMILES OC(=O)C1CCn2c1ccc2C(=O)c1ccccc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	7.4	n/a
University of Colorado					Assay Description Experiments were performed in a 384-well format (Greiner no. 781207) as per the conditions noted here. Caspase-1: 2.5 nM enzyme, 6.5 mM WEHD substrat...				Cell Chem Biol 24: 281-292 (2017) Article DOI: 10.1016/j.chembiol.2017.02.003 BindingDB Entry DOI: 10.7270/Q2C53JQX
University of Colorado					More data for this Ligand-Target Pair
ATP-binding cassette sub-family C member 4 (Homo sapiens (Human))	BDBM85511 (CAS_74103-07-4 \| KETOROLAC \| Ketorolac tris salt \|...) Show SMILES OC(=O)C1CCn2c1ccc2C(=O)c1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...				Toxicol Sci 136: 216-41 (2013) Article DOI: 10.1093/toxsci/kft176 BindingDB Entry DOI: 10.7270/Q2JM2D2D
Amgen Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM85511 (CAS_74103-07-4 \| KETOROLAC \| Ketorolac tris salt \|...) Show SMILES OC(=O)C1CCn2c1ccc2C(=O)c1ccccc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars	DrugBank	n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Caspase-1 (Homo sapiens (Human))	BDBM85511 (CAS_74103-07-4 \| KETOROLAC \| Ketorolac tris salt \|...) Show SMILES OC(=O)C1CCn2c1ccc2C(=O)c1ccccc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.80E+4	n/a	n/a	n/a	n/a	7.4	n/a
University of Colorado					Assay Description Experiments were performed in a 384-well format (Greiner no. 781207) as per the conditions noted here. Caspase-1: 2.5 nM enzyme, 6.5 mM WEHD substrat...				Cell Chem Biol 24: 281-292 (2017) Article DOI: 10.1016/j.chembiol.2017.02.003 BindingDB Entry DOI: 10.7270/Q2C53JQX
University of Colorado					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 1 (Homo sapiens (Human))	BDBM85511 (CAS_74103-07-4 \| KETOROLAC \| Ketorolac tris salt \|...) Show SMILES OC(=O)C1CCn2c1ccc2C(=O)c1ccccc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	3.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Kagoshima University Curated by ChEMBL					Assay Description Inhibition of PAK1 in human A549 cells using myelin basic protein as substrate preincubated for 24 hrs followed by PAK1 immunoprecipation and substra...				Eur J Med Chem 126: 270-276 (2017) Article DOI: 10.1016/j.ejmech.2016.11.038 BindingDB Entry DOI: 10.7270/Q2T72KP7
Kagoshima University Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM85511 (CAS_74103-07-4 \| KETOROLAC \| Ketorolac tris salt \|...) Show SMILES OC(=O)C1CCn2c1ccc2C(=O)c1ccccc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars	DrugBank Article PubMed	n/a	n/a	6.05E+4	n/a	n/a	n/a	n/a	n/a	n/a
Faculdade de Ci�ncias e Tecnologia-UNL Curated by ChEMBL					Assay Description Instantaneous inhibition of human COX2 measured immediately after incubation of enzyme with compound				J Med Chem 54: 8555-62 (2011) Article DOI: 10.1021/jm201090k BindingDB Entry DOI: 10.7270/Q2W95B6H
Faculdade de Ci�ncias e Tecnologia-UNL Curated by ChEMBL					More data for this Ligand-Target Pair
ATP-binding cassette sub-family C member 3 (Homo sapiens (Human))	BDBM85511 (CAS_74103-07-4 \| KETOROLAC \| Ketorolac tris salt \|...) Show SMILES OC(=O)C1CCn2c1ccc2C(=O)c1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...				Toxicol Sci 136: 216-41 (2013) Article DOI: 10.1093/toxsci/kft176 BindingDB Entry DOI: 10.7270/Q2JM2D2D
Amgen Inc Curated by ChEMBL					More data for this Ligand-Target Pair
ATP-binding cassette sub-family C member 2 (Homo sapiens (Human))	BDBM85511 (CAS_74103-07-4 \| KETOROLAC \| Ketorolac tris salt \|...) Show SMILES OC(=O)C1CCn2c1ccc2C(=O)c1ccccc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...				Toxicol Sci 136: 216-41 (2013) Article DOI: 10.1093/toxsci/kft176 BindingDB Entry DOI: 10.7270/Q2JM2D2D
Amgen Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Bile salt export pump (Homo sapiens (Human))	BDBM85511 (CAS_74103-07-4 \| KETOROLAC \| Ketorolac tris salt \|...) Show SMILES OC(=O)C1CCn2c1ccc2C(=O)c1ccccc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...				Toxicol Sci 136: 216-41 (2013) Article DOI: 10.1093/toxsci/kft176 BindingDB Entry DOI: 10.7270/Q2JM2D2D
Amgen Inc Curated by ChEMBL					More data for this Ligand-Target Pair