Compile Data Set for Download or QSAR

Found 126 hits of ic50 for UniProtKB: P70604   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM392076 (US10301272, Example 7/9) Show SMILES CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCCCC2)C(=O)N[C@H]2C[C@@H](C2)C(O)=O)c2ccccc12 |r,wU:27.28,wD:29.33,(8.76,1.15,;7.67,.06,;6.19,.46,;7.28,1.55,;8.07,-1.42,;6.98,-2.51,;6.59,-4,;8.07,-3.6,;5.5,-2.11,;5.1,-.63,;3.61,-.23,;2.52,-1.32,;1.03,-.92,;.56,.55,;-.98,.55,;-1.46,-.92,;-.21,-1.82,;-.21,-3.36,;-1.55,-4.13,;-2.88,-3.36,;-4.21,-4.13,;-4.21,-5.67,;-2.88,-6.44,;-1.55,-5.67,;-2.07,1.64,;-1.67,3.12,;-3.56,1.24,;-4.65,2.33,;-6.19,2.33,;-6.19,3.87,;-4.65,3.87,;-7.28,4.96,;-6.88,6.44,;-8.76,4.56,;2.92,-2.8,;1.83,-3.89,;2.23,-5.38,;3.72,-5.78,;4.81,-4.69,;4.41,-3.2,)| Show InChI InChI=1S/C30H37N3O5S2/c1-30(2,3)33-40(37,38)25-14-13-23(21-11-7-8-12-22(21)25)26-24(15-18-9-5-4-6-10-18)32-28(39-26)27(34)31-20-16-19(17-20)29(35)36/h7-8,11-14,18-20,33H,4-6,9-10,15-17H2,1-3H3,(H,31,34)(H,35,36)/t19-,20-	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.0120	n/a	n/a	n/a	n/a	n/a	n/a
Phenex Pharmaceuticals AG Curated by ChEMBL					Assay Description Displacement of [125I]apamin from rat brain SkCa channel after 60 mins by scintillation counting analysis				Bioorg Med Chem Lett 28: 1446-1455 (2018) Article DOI: 10.1016/j.bmcl.2018.03.093 BindingDB Entry DOI: 10.7270/Q27W6FPC
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50155248 (CHEMBL3774478) Show SMILES [H][C@@]12CCCN1C(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@@]1([H])CSSC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@]([H])(CSSC[C@@H](N)C(=O)N[C@@H](CC(N)=O)C(=O)N1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@@]([H])(NC(=O)[C@H](CCC(O)=O)NC2=O)[C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O |r| Show InChI InChI=1S/C79H131N31O24S4/c1-35(2)26-49-70(127)107-51-31-136-135-30-41(81)63(120)105-50(28-57(84)114)71(128)108-53(73(130)99-42(12-7-8-22-80)64(121)96-38(5)77(134)110-25-11-15-54(110)75(132)102-47(18-21-58(115)116)69(126)109-59(39(6)111)76(133)95-37(4)62(119)104-49)33-138-137-32-52(106-66(123)44(14-10-24-92-79(88)89)98-65(122)43(13-9-23-91-78(86)87)97-61(118)36(3)94-72(51)129)74(131)101-45(16-19-55(82)112)67(124)100-46(17-20-56(83)113)68(125)103-48(60(85)117)27-40-29-90-34-93-40/h29,34-39,41-54,59,111H,7-28,30-33,80-81H2,1-6H3,(H2,82,112)(H2,83,113)(H2,84,114)(H2,85,117)(H,90,93)(H,94,129)(H,95,133)(H,96,121)(H,97,118)(H,98,122)(H,99,130)(H,100,124)(H,101,131)(H,102,132)(H,103,125)(H,104,119)(H,105,120)(H,106,123)(H,107,127)(H,108,128)(H,109,126)(H,115,116)(H4,86,87,91)(H4,88,89,92)/t36-,37-,38-,39+,41+,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54-,59-/m0/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.0160	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Medical College Curated by ChEMBL					Assay Description Displacement of [125I]apamin from rat cerebral cortex small conductance calcium-activated potassium channel				Bioorg Med Chem 24: 1793-810 (2016) Article DOI: 10.1016/j.bmc.2016.03.006 BindingDB Entry DOI: 10.7270/Q2J67JS7
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50092131 (1,7-diazonia-15,21-diazapentacyclo[20.6.2.27,14.08...) Show SMILES C1CCN[c+]2ccn(CCCCCn3cc[c+](NCC1)c1ccccc31)c1ccccc21 Show InChI InChI=1S/C28H34N4/c1-7-17-29-25-15-21-31(27-13-5-3-11-23(25)27)19-9-2-10-20-32-22-16-26(30-18-8-1)24-12-4-6-14-28(24)32/h3-6,11-16,21-22,29-30H,1-2,7-10,17-20H2/q+2	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Aristotelian University of Thessaloniki Curated by ChEMBL					Assay Description Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activity				Bioorg Med Chem Lett 14: 4231-5 (2004) Article DOI: 10.1016/j.bmcl.2004.06.011 BindingDB Entry DOI: 10.7270/Q2FF3W4T
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50061977 (17,25-diazonia-2,9-diazaheptacyclo[23.6.2.24,7.210...) Show SMILES C1N[c+]2ccn(Cc3cccc(Cn4cc[c+](NCc5ccc1cc5)c1ccccc41)c3)c1ccccc21 Show InChI InChI=1S/C34H30N4/c1-3-10-33-29(8-1)31-16-18-37(33)23-27-6-5-7-28(20-27)24-38-19-17-32(30-9-2-4-11-34(30)38)36-22-26-14-12-25(13-15-26)21-35-31/h1-20,35-36H,21-24H2/q+2	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...				J Med Chem 43: 420-31 (2000) Article DOI: 10.1021/jm9902537 BindingDB Entry DOI: 10.7270/Q21V5HQ2
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50061977 (17,25-diazonia-2,9-diazaheptacyclo[23.6.2.24,7.210...) Show SMILES C1N[c+]2ccn(Cc3cccc(Cn4cc[c+](NCc5ccc1cc5)c1ccccc41)c3)c1ccccc21 Show InChI InChI=1S/C34H30N4/c1-3-10-33-29(8-1)31-16-18-37(33)23-27-6-5-7-28(20-27)24-38-19-17-32(30-9-2-4-11-34(30)38)36-22-26-14-12-25(13-15-26)21-35-31/h1-20,35-36H,21-24H2/q+2	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Aristotelian University of Thessaloniki Curated by ChEMBL					Assay Description Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activity				Bioorg Med Chem Lett 14: 4231-5 (2004) Article DOI: 10.1016/j.bmcl.2004.06.011 BindingDB Entry DOI: 10.7270/Q2FF3W4T
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50474856 (CHEMBL184300) Show SMILES C1CC[n+]2ccc(NCCCCNc3cc[n+](CC1)c1ccccc31)c1ccccc21 Show InChI InChI=1S/C27H30N4/c1-8-18-30-20-14-24(22-10-2-4-12-26(22)30)28-16-6-7-17-29-25-15-21-31(19-9-1)27-13-5-3-11-23(25)27/h2-5,10-15,20-21H,1,6-9,16-19H2/p+2/b28-24+,29-25+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Aristotelian University of Thessaloniki Curated by ChEMBL					Assay Description Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activity				Bioorg Med Chem Lett 14: 4231-5 (2004) Article DOI: 10.1016/j.bmcl.2004.06.011 BindingDB Entry DOI: 10.7270/Q2FF3W4T
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50474870 (CHEMBL185146) Show SMILES C1CCNc2cc[n+](Cc3cccc(C[n+]4ccc(NC1)c1ccccc41)c3)c1ccccc21 Show InChI InChI=1S/C30H28N4/c1-3-12-29-25(10-1)27-14-18-33(29)21-23-8-7-9-24(20-23)22-34-19-15-28(32-17-6-5-16-31-27)26-11-2-4-13-30(26)34/h1-4,7-15,18-20H,5-6,16-17,21-22H2/p+2/b31-27+,32-28?	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Aristotelian University of Thessaloniki Curated by ChEMBL					Assay Description Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activity				Bioorg Med Chem Lett 14: 4231-5 (2004) Article DOI: 10.1016/j.bmcl.2004.06.011 BindingDB Entry DOI: 10.7270/Q2FF3W4T
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50474869 (CHEMBL181911) Show SMILES C1CCCNc2cc[n+](CCCCC[n+]3ccc(NCC1)c1ccccc31)c1ccccc21 Show InChI InChI=1S/C29H34N4/c1-2-9-19-31-27-17-23-33(29-15-7-5-13-25(27)29)21-11-3-10-20-32-22-16-26(30-18-8-1)24-12-4-6-14-28(24)32/h4-7,12-17,22-23H,1-3,8-11,18-21H2/p+2/b30-26+,31-27?	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Aristotelian University of Thessaloniki Curated by ChEMBL					Assay Description Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activity				Bioorg Med Chem Lett 14: 4231-5 (2004) Article DOI: 10.1016/j.bmcl.2004.06.011 BindingDB Entry DOI: 10.7270/Q2FF3W4T
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50474865 (CHEMBL183644) Show SMILES C1CCNc2cc[n+](CCCC[n+]3ccc(NCC1)c1ccccc31)c1ccccc21 Show InChI InChI=1S/C27H30N4/c1-6-16-28-24-14-20-30(26-12-4-2-10-22(24)26)18-8-9-19-31-21-15-25(29-17-7-1)23-11-3-5-13-27(23)31/h2-5,10-15,20-21H,1,6-9,16-19H2/p+2/b28-24+,29-25+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Aristotelian University of Thessaloniki Curated by ChEMBL					Assay Description Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activity				Bioorg Med Chem Lett 14: 4231-5 (2004) Article DOI: 10.1016/j.bmcl.2004.06.011 BindingDB Entry DOI: 10.7270/Q2FF3W4T
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50474867 (CHEMBL184858) Show SMILES C1CCC[n+]2ccc(NCCCCCNc3cc[n+](CC1)c1ccccc31)c1ccccc21 Show InChI InChI=1S/C29H34N4/c1-2-11-21-33-23-17-27(25-13-5-7-15-29(25)33)31-19-9-3-8-18-30-26-16-22-32(20-10-1)28-14-6-4-12-24(26)28/h4-7,12-17,22-23H,1-3,8-11,18-21H2/p+2/b30-26+,31-27+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Aristotelian University of Thessaloniki Curated by ChEMBL					Assay Description Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activity				Bioorg Med Chem Lett 14: 4231-5 (2004) Article DOI: 10.1016/j.bmcl.2004.06.011 BindingDB Entry DOI: 10.7270/Q2FF3W4T
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50474866 (CHEMBL181912) Show SMILES C1CNc2cc[n+](Cc3cccc(C[n+]4ccc(NC1)c1ccccc41)c3)c1ccccc21 Show InChI InChI=1S/C29H26N4/c1-3-11-28-24(9-1)26-13-17-32(28)20-22-7-5-8-23(19-22)21-33-18-14-27(31-16-6-15-30-26)25-10-2-4-12-29(25)33/h1-5,7-14,17-19H,6,15-16,20-21H2/p+2/b30-26+,31-27+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Aristotelian University of Thessaloniki Curated by ChEMBL					Assay Description Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activity				Bioorg Med Chem Lett 14: 4231-5 (2004) Article DOI: 10.1016/j.bmcl.2004.06.011 BindingDB Entry DOI: 10.7270/Q2FF3W4T
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50473100 (CHEMBL344807) Show SMILES COc1c2C[n+]3ccc(NCc4ccc(CNc5cc[n+](Cc1ccc2)c1ccccc51)cc4)c1ccccc31 Show InChI InChI=1S/C35H30N4O/c1-40-35-27-7-6-8-28(35)24-39-20-18-32(30-10-3-5-12-34(30)39)37-22-26-15-13-25(14-16-26)21-36-31-17-19-38(23-27)33-11-4-2-9-29(31)33/h2-20H,21-24H2,1H3/p+2	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...				J Med Chem 43: 420-31 (2000) Article DOI: 10.1021/jm9902537 BindingDB Entry DOI: 10.7270/Q21V5HQ2
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50473103 (CHEMBL430146) Show SMILES C1Nc2cc[n+](Cc3ccc(C[n+]4ccc(NCc5ccc1cc5)c1ccccc41)cc3)c1ccccc21 Show InChI InChI=1S/C34H28N4/c1-3-7-33-29(5-1)31-17-19-37(33)23-27-13-15-28(16-14-27)24-38-20-18-32(30-6-2-4-8-34(30)38)36-22-26-11-9-25(10-12-26)21-35-31/h1-20H,21-24H2/p+2	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
Aristotelian University of Thessaloniki Curated by ChEMBL					Assay Description Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activity				Bioorg Med Chem Lett 14: 4231-5 (2004) Article DOI: 10.1016/j.bmcl.2004.06.011 BindingDB Entry DOI: 10.7270/Q2FF3W4T
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50473103 (CHEMBL430146) Show SMILES C1Nc2cc[n+](Cc3ccc(C[n+]4ccc(NCc5ccc1cc5)c1ccccc41)cc3)c1ccccc21 Show InChI InChI=1S/C34H28N4/c1-3-7-33-29(5-1)31-17-19-37(33)23-27-13-15-28(16-14-27)24-38-20-18-32(30-6-2-4-8-34(30)38)36-22-26-11-9-25(10-12-26)21-35-31/h1-20H,21-24H2/p+2	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...				J Med Chem 43: 420-31 (2000) Article DOI: 10.1021/jm9902537 BindingDB Entry DOI: 10.7270/Q21V5HQ2
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50474868 (CHEMBL184891) Show SMILES C1CC[n+]2ccc(NCCCNc3cc[n+](CC1)c1ccccc31)c1ccccc21 Show InChI InChI=1S/C26H28N4/c1-6-17-29-19-13-23(21-9-2-4-11-25(21)29)27-15-8-16-28-24-14-20-30(18-7-1)26-12-5-3-10-22(24)26/h2-5,9-14,19-20H,1,6-8,15-18H2/p+2/b27-23+,28-24+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Aristotelian University of Thessaloniki Curated by ChEMBL					Assay Description Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activity				Bioorg Med Chem Lett 14: 4231-5 (2004) Article DOI: 10.1016/j.bmcl.2004.06.011 BindingDB Entry DOI: 10.7270/Q2FF3W4T
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50474871 (CHEMBL182716) Show SMILES C1CCNc2cc[n+](Cc3cccc(C[n+]4ccc(NCC1)c1ccccc41)c3)c1ccccc21 Show InChI InChI=1S/C31H30N4/c1-6-17-32-28-15-19-34(30-13-4-2-11-26(28)30)22-24-9-8-10-25(21-24)23-35-20-16-29(33-18-7-1)27-12-3-5-14-31(27)35/h2-5,8-16,19-21H,1,6-7,17-18,22-23H2/p+2/b32-28+,33-29+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
Aristotelian University of Thessaloniki Curated by ChEMBL					Assay Description Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activity				Bioorg Med Chem Lett 14: 4231-5 (2004) Article DOI: 10.1016/j.bmcl.2004.06.011 BindingDB Entry DOI: 10.7270/Q2FF3W4T
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50474863 (CHEMBL360624) Show SMILES C1CCCNc2cc[n+](Cc3cccc(C[n+]4ccc(NCC1)c1ccccc41)c3)c1ccccc21 Show InChI InChI=1S/C32H32N4/c1-2-8-19-34-30-17-21-36(32-15-6-4-13-28(30)32)24-26-11-9-10-25(22-26)23-35-20-16-29(33-18-7-1)27-12-3-5-14-31(27)35/h3-6,9-17,20-22H,1-2,7-8,18-19,23-24H2/p+2/b33-29+,34-30?	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
Aristotelian University of Thessaloniki Curated by ChEMBL					Assay Description Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activity				Bioorg Med Chem Lett 14: 4231-5 (2004) Article DOI: 10.1016/j.bmcl.2004.06.011 BindingDB Entry DOI: 10.7270/Q2FF3W4T
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50474872 (CHEMBL1180184) Show SMILES C1CCNc2cc[n+](CCCC[n+]3ccc(NC1)c1ccccc31)c1ccccc21 Show InChI InChI=1S/C26H28N4/c1-3-11-25-21(9-1)23-13-19-29(25)17-7-8-18-30-20-14-24(28-16-6-5-15-27-23)22-10-2-4-12-26(22)30/h1-4,9-14,19-20H,5-8,15-18H2/p+2/b27-23-,28-24+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Aristotelian University of Thessaloniki Curated by ChEMBL					Assay Description Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activity				Bioorg Med Chem Lett 14: 4231-5 (2004) Article DOI: 10.1016/j.bmcl.2004.06.011 BindingDB Entry DOI: 10.7270/Q2FF3W4T
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50474858 (CHEMBL186139) Show SMILES C1CCCNc2cc[n+](CCCCCC[n+]3ccc(NCC1)c1ccccc31)c1ccccc21 Show InChI InChI=1S/C30H36N4/c1-2-10-20-32-28-18-24-34(30-16-8-6-14-26(28)30)22-12-4-3-11-21-33-23-17-27(31-19-9-1)25-13-5-7-15-29(25)33/h5-8,13-18,23-24H,1-4,9-12,19-22H2/p+2/b31-27+,32-28?	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
Aristotelian University of Thessaloniki Curated by ChEMBL					Assay Description Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activity				Bioorg Med Chem Lett 14: 4231-5 (2004) Article DOI: 10.1016/j.bmcl.2004.06.011 BindingDB Entry DOI: 10.7270/Q2FF3W4T
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50150389 (17,23-diazonia-2,9-diazahexacyclo[21.6.2.24,7.210,...) Show SMILES C1CCn2cc[c+](NCc3ccc(CN[c+]4ccn(CC1)c1ccccc41)cc3)c1ccccc21 Show InChI InChI=1S/C31H32N4/c1-6-18-34-20-16-28(26-8-2-4-10-30(26)34)32-22-24-12-14-25(15-13-24)23-33-29-17-21-35(19-7-1)31-11-5-3-9-27(29)31/h2-5,8-17,20-21,32-33H,1,6-7,18-19,22-23H2/q+2	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
Aristotelian University of Thessaloniki Curated by ChEMBL					Assay Description Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activity				Bioorg Med Chem Lett 14: 4231-5 (2004) Article DOI: 10.1016/j.bmcl.2004.06.011 BindingDB Entry DOI: 10.7270/Q2FF3W4T
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50473097 (CHEMBL136488) Show SMILES Oc1c2C[n+]3ccc(NCc4ccc(CNc5cc[n+](Cc1ccc2)c1ccccc51)cc4)c1ccccc31 Show InChI InChI=1S/C34H28N4O/c39-34-26-6-5-7-27(34)23-38-19-17-31(29-9-2-4-11-33(29)38)36-21-25-14-12-24(13-15-25)20-35-30-16-18-37(22-26)32-10-3-1-8-28(30)32/h1-19,39H,20-23H2/p+2	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...				J Med Chem 43: 420-31 (2000) Article DOI: 10.1021/jm9902537 BindingDB Entry DOI: 10.7270/Q21V5HQ2
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50474859 (CHEMBL185258) Show SMILES C1CCC[n+]2ccc(NCc3ccc(CNc4cc[n+](CC1)c1ccccc41)cc3)c1ccccc21 Show InChI InChI=1S/C32H32N4/c1-2-8-20-36-22-18-30(28-10-4-6-12-32(28)36)34-24-26-15-13-25(14-16-26)23-33-29-17-21-35(19-7-1)31-11-5-3-9-27(29)31/h3-6,9-18,21-22H,1-2,7-8,19-20,23-24H2/p+2/b33-29+,34-30+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	65	n/a	n/a	n/a	n/a	n/a	n/a
Aristotelian University of Thessaloniki Curated by ChEMBL					Assay Description Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activity				Bioorg Med Chem Lett 14: 4231-5 (2004) Article DOI: 10.1016/j.bmcl.2004.06.011 BindingDB Entry DOI: 10.7270/Q2FF3W4T
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50473106 (CHEMBL137175) Show SMILES C1Nc2cc[n+](Cc3ccc(C[n+]4ccc(NCc5cccc1c5)c1ccccc41)cc3)c1ccccc21 Show InChI InChI=1S/C34H28N4/c1-3-10-33-29(8-1)31-16-18-37(33)23-25-12-14-26(15-13-25)24-38-19-17-32(30-9-2-4-11-34(30)38)36-22-28-7-5-6-27(20-28)21-35-31/h1-20H,21-24H2/p+2/b35-31+,36-32?	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
Aristotelian University of Thessaloniki Curated by ChEMBL					Assay Description Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activity				Bioorg Med Chem Lett 14: 4231-5 (2004) Article DOI: 10.1016/j.bmcl.2004.06.011 BindingDB Entry DOI: 10.7270/Q2FF3W4T
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50473106 (CHEMBL137175) Show SMILES C1Nc2cc[n+](Cc3ccc(C[n+]4ccc(NCc5cccc1c5)c1ccccc41)cc3)c1ccccc21 Show InChI InChI=1S/C34H28N4/c1-3-10-33-29(8-1)31-16-18-37(33)23-25-12-14-26(15-13-25)24-38-19-17-32(30-9-2-4-11-34(30)38)36-22-28-7-5-6-27(20-28)21-35-31/h1-20H,21-24H2/p+2/b35-31+,36-32?	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...				J Med Chem 43: 420-31 (2000) Article DOI: 10.1021/jm9902537 BindingDB Entry DOI: 10.7270/Q21V5HQ2
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50084848 (BIs-cyclo(4N-pentyl-1-(4-methylbenzyl)-4-quinolini...) Show SMILES C1CCCCCN[c+]2ccn(Cc3ccc(Cc4ccc(Cn5cc[c+](NCCCC1)c1ccccc51)cc4)cc3)c1ccccc21 Show InChI InChI=1S/C43H48N4/c1-2-4-6-12-28-45-41-26-30-47(43-16-10-8-14-39(41)43)33-37-23-19-35(20-24-37)31-34-17-21-36(22-18-34)32-46-29-25-40(44-27-11-5-3-1)38-13-7-9-15-42(38)46/h7-10,13-26,29-30,44-45H,1-6,11-12,27-28,31-33H2/q+2	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...				J Med Chem 43: 420-31 (2000) Article DOI: 10.1021/jm9902537 BindingDB Entry DOI: 10.7270/Q21V5HQ2
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (Rattus norvegicus (Rat))	BDBM50084848 (BIs-cyclo(4N-pentyl-1-(4-methylbenzyl)-4-quinolini...) Show SMILES C1CCCCCN[c+]2ccn(Cc3ccc(Cc4ccc(Cn5cc[c+](NCCCC1)c1ccccc51)cc4)cc3)c1ccccc21 Show InChI InChI=1S/C43H48N4/c1-2-4-6-12-28-45-41-26-30-47(43-16-10-8-14-39(41)43)33-37-23-19-35(20-24-37)31-34-17-21-36(22-18-34)32-46-29-25-40(44-27-11-5-3-1)38-13-7-9-15-42(38)46/h7-10,13-26,29-30,44-45H,1-6,11-12,27-28,31-33H2/q+2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...				Bioorg Med Chem Lett 7: 7-10 (1997) Article DOI: 10.1016/S0960-894X(96)00568-9 BindingDB Entry DOI: 10.7270/Q22B8Z1R
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50473094 (CHEMBL137155) Show SMILES Cc1ccc-2c(Cc3cc(C[n+]4ccc(NCCCCCCCCCCNc5cc[n+](C)c6ccccc56)c5ccccc45)ccc-23)c1 Show InChI InChI=1S/C44H48N4/c1-33-19-21-37-35(29-33)31-36-30-34(20-22-38(36)37)32-48-28-24-42(40-16-10-12-18-44(40)48)46-26-14-8-6-4-3-5-7-13-25-45-41-23-27-47(2)43-17-11-9-15-39(41)43/h9-12,15-24,27-30H,3-8,13-14,25-26,31-32H2,1-2H3/p+2	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...				J Med Chem 43: 420-31 (2000) Article DOI: 10.1021/jm9902537 BindingDB Entry DOI: 10.7270/Q21V5HQ2
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (Rattus norvegicus (Rat))	BDBM50289333 (21,35-diazonia-2,13-diazaoctacyclo[33.6.2.214,21.1...) Show SMILES C1c2cc3Cn4cc[c+](NCCCCCCCCCCN[c+]5ccn(Cc6ccc(c1c6)-c2cc3)c1ccccc51)c1ccccc41 Show InChI InChI=1S/C43H46N4/c1-2-4-6-12-24-45-41-22-26-47(43-16-10-8-14-39(41)43)31-33-18-20-37-35(28-33)29-34-27-32(17-19-36(34)37)30-46-25-21-40(44-23-11-5-3-1)38-13-7-9-15-42(38)46/h7-10,13-22,25-28,44-45H,1-6,11-12,23-24,29-31H2/q+2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...				Bioorg Med Chem Lett 7: 7-10 (1997) Article DOI: 10.1016/S0960-894X(96)00568-9 BindingDB Entry DOI: 10.7270/Q22B8Z1R
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50473098 (CHEMBL342213) Show SMILES Oc1c2C[n+]3ccc(NCc4ccc(CNc5cc[n+](Cc1cc(I)c2)c1ccccc51)cc4)c1ccccc31 Show InChI InChI=1S/C34H27IN4O/c35-27-17-25-21-38-15-13-30(28-5-1-3-7-32(28)38)36-19-23-9-11-24(12-10-23)20-37-31-14-16-39(22-26(18-27)34(25)40)33-8-4-2-6-29(31)33/h1-18,40H,19-22H2/p+2	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...				J Med Chem 43: 420-31 (2000) Article DOI: 10.1021/jm9902537 BindingDB Entry DOI: 10.7270/Q21V5HQ2
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50084852 (1,14-diazonia-22,33-diazaheptacyclo[32.6.2.214,21....) Show SMILES C1CCCCCN[c+]2ccn(Cc3cccc(c3)-c3cccc(Cn4cc[c+](NCCCC1)c1ccccc41)c3)c1ccccc21 Show InChI InChI=1S/C42H46N4/c1-2-4-6-12-26-44-40-24-28-46(42-22-10-8-20-38(40)42)32-34-16-14-18-36(30-34)35-17-13-15-33(29-35)31-45-27-23-39(43-25-11-5-3-1)37-19-7-9-21-41(37)45/h7-10,13-24,27-30,43-44H,1-6,11-12,25-26,31-32H2/q+2	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...				J Med Chem 43: 420-31 (2000) Article DOI: 10.1021/jm9902537 BindingDB Entry DOI: 10.7270/Q21V5HQ2
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (Rattus norvegicus (Rat))	BDBM50084852 (1,14-diazonia-22,33-diazaheptacyclo[32.6.2.214,21....) Show SMILES C1CCCCCN[c+]2ccn(Cc3cccc(c3)-c3cccc(Cn4cc[c+](NCCCC1)c1ccccc41)c3)c1ccccc21 Show InChI InChI=1S/C42H46N4/c1-2-4-6-12-26-44-40-24-28-46(42-22-10-8-20-38(40)42)32-34-16-14-18-36(30-34)35-17-13-15-33(29-35)31-45-27-23-39(43-25-11-5-3-1)37-19-7-9-21-41(37)45/h7-10,13-24,27-30,43-44H,1-6,11-12,25-26,31-32H2/q+2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...				Bioorg Med Chem Lett 7: 7-10 (1997) Article DOI: 10.1016/S0960-894X(96)00568-9 BindingDB Entry DOI: 10.7270/Q22B8Z1R
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50473099 (CHEMBL140380) Show SMILES C1c2cc3C[n+]4ccc(NCc5ccc(cc5)-c5ccc(CNc6cc[n+](Cc7ccc(c1c7)-c2cc3)c1ccccc61)cc5)c1ccccc41 Show InChI InChI=1S/C47H36N4/c1-3-7-46-42(5-1)44-21-23-50(46)30-34-13-19-40-38(25-34)27-39-26-35(14-20-41(39)40)31-51-24-22-45(43-6-2-4-8-47(43)51)49-29-33-11-17-37(18-12-33)36-15-9-32(10-16-36)28-48-44/h1-26H,27-31H2/p+2/b48-44+,49-45+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...				J Med Chem 43: 420-31 (2000) Article DOI: 10.1021/jm9902537 BindingDB Entry DOI: 10.7270/Q21V5HQ2
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50473107 (CHEMBL341700) Show SMILES C1Nc2cc[n+](Cc3cccc(C[n+]4ccc(NCc5cccc1c5)c1ccccc41)c3)c1ccccc21 Show InChI InChI=1S/C34H28N4/c1-3-13-33-29(11-1)31-15-17-37(33)23-27-9-6-10-28(20-27)24-38-18-16-32(30-12-2-4-14-34(30)38)36-22-26-8-5-7-25(19-26)21-35-31/h1-20H,21-24H2/p+2/b35-31-,36-32?	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...				J Med Chem 43: 420-31 (2000) Article DOI: 10.1021/jm9902537 BindingDB Entry DOI: 10.7270/Q21V5HQ2
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50473107 (CHEMBL341700) Show SMILES C1Nc2cc[n+](Cc3cccc(C[n+]4ccc(NCc5cccc1c5)c1ccccc41)c3)c1ccccc21 Show InChI InChI=1S/C34H28N4/c1-3-13-33-29(11-1)31-15-17-37(33)23-27-9-6-10-28(20-27)24-38-18-16-32(30-12-2-4-14-34(30)38)36-22-26-8-5-7-25(19-26)21-35-31/h1-20H,21-24H2/p+2/b35-31-,36-32?	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
Aristotelian University of Thessaloniki Curated by ChEMBL					Assay Description Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activity				Bioorg Med Chem Lett 14: 4231-5 (2004) Article DOI: 10.1016/j.bmcl.2004.06.011 BindingDB Entry DOI: 10.7270/Q2FF3W4T
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50474857 (CHEMBL185106) Show SMILES C1CC[n+]2ccc(NCCCNc3cc[n+](C1)c1ccccc31)c1ccccc21 Show InChI InChI=1S/C25H26N4/c1-3-10-24-20(8-1)22-12-18-28(24)16-5-6-17-29-19-13-23(27-15-7-14-26-22)21-9-2-4-11-25(21)29/h1-4,8-13,18-19H,5-7,14-17H2/p+2/b26-22+,27-23+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
Aristotelian University of Thessaloniki Curated by ChEMBL					Assay Description Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activity				Bioorg Med Chem Lett 14: 4231-5 (2004) Article DOI: 10.1016/j.bmcl.2004.06.011 BindingDB Entry DOI: 10.7270/Q2FF3W4T
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50084849 (Bis-quinolinium cyclophane analogue | CHEMBL258254...) Show SMILES C1CCCCCN[c+]2ccn(Cc3ccc(cc3)\C=C/c3ccc(Cn4cc[c+](NCCCC1)c1ccccc41)cc3)c1ccccc21 |c:19| Show InChI InChI=1S/C44H48N4/c1-2-4-6-12-30-46-42-28-32-48(44-16-10-8-14-40(42)44)34-38-25-21-36(22-26-38)18-17-35-19-23-37(24-20-35)33-47-31-27-41(45-29-11-5-3-1)39-13-7-9-15-43(39)47/h7-10,13-28,31-32,45-46H,1-6,11-12,29-30,33-34H2/q+2/b18-17-	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...				J Med Chem 43: 420-31 (2000) Article DOI: 10.1021/jm9902537 BindingDB Entry DOI: 10.7270/Q21V5HQ2
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50474873 (CHEMBL185137) Show SMILES C1CC[n+]2ccc(NCc3ccc(CNc4cc[n+](C1)c1ccccc41)cc3)c1ccccc21 Show InChI InChI=1S/C30H28N4/c1-3-9-29-25(7-1)27-15-19-33(29)17-5-6-18-34-20-16-28(26-8-2-4-10-30(26)34)32-22-24-13-11-23(12-14-24)21-31-27/h1-4,7-16,19-20H,5-6,17-18,21-22H2/p+2/b31-27+,32-28+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
Aristotelian University of Thessaloniki Curated by ChEMBL					Assay Description Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activity				Bioorg Med Chem Lett 14: 4231-5 (2004) Article DOI: 10.1016/j.bmcl.2004.06.011 BindingDB Entry DOI: 10.7270/Q2FF3W4T
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (Rattus norvegicus (Rat))	BDBM50084849 (Bis-quinolinium cyclophane analogue | CHEMBL258254...) Show SMILES C1CCCCCN[c+]2ccn(Cc3ccc(cc3)\C=C/c3ccc(Cn4cc[c+](NCCCC1)c1ccccc41)cc3)c1ccccc21 |c:19| Show InChI InChI=1S/C44H48N4/c1-2-4-6-12-30-46-42-28-32-48(44-16-10-8-14-40(42)44)34-38-25-21-36(22-26-38)18-17-35-19-23-37(24-20-35)33-47-31-27-41(45-29-11-5-3-1)39-13-7-9-15-43(39)47/h7-10,13-28,31-32,45-46H,1-6,11-12,29-30,33-34H2/q+2/b18-17-	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...				Bioorg Med Chem Lett 7: 7-10 (1997) Article DOI: 10.1016/S0960-894X(96)00568-9 BindingDB Entry DOI: 10.7270/Q22B8Z1R
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50474862 (CHEMBL425707) Show SMILES C1C[n+]2ccc(NCc3ccc(CNc4cc[n+](C1)c1ccccc41)cc3)c1ccccc21 Show InChI InChI=1S/C29H26N4/c1-3-8-28-24(6-1)26-14-18-32(28)16-5-17-33-19-15-27(25-7-2-4-9-29(25)33)31-21-23-12-10-22(11-13-23)20-30-26/h1-4,6-15,18-19H,5,16-17,20-21H2/p+2/b30-26+,31-27+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
Aristotelian University of Thessaloniki Curated by ChEMBL					Assay Description Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activity				Bioorg Med Chem Lett 14: 4231-5 (2004) Article DOI: 10.1016/j.bmcl.2004.06.011 BindingDB Entry DOI: 10.7270/Q2FF3W4T
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50473102 (CHEMBL137266) Show SMILES C1Nc2cc[n+](Cc3ccc(cc3)-c3ccc(C[n+]4ccc(NCc5ccc(Cc6ccc1cc6)cc5)c1ccccc41)cc3)c1ccccc21 Show InChI InChI=1S/C47H38N4/c1-3-7-46-42(5-1)44-25-27-50(46)32-38-17-21-40(22-18-38)41-23-19-39(20-24-41)33-51-28-26-45(43-6-2-4-8-47(43)51)49-31-37-15-11-35(12-16-37)29-34-9-13-36(14-10-34)30-48-44/h1-28H,29-33H2/p+2	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...				J Med Chem 43: 420-31 (2000) Article DOI: 10.1021/jm9902537 BindingDB Entry DOI: 10.7270/Q21V5HQ2
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50084839 (Bis-quinolinium cyclophane analogue | CHEMBL6266 |...) Show SMILES C1CCCCCN[c+]2ccn(Cc3ccc(cc3)-c3ccc(Cn4cc[c+](NCCCC1)c1ccccc41)cc3)c1ccccc21 Show InChI InChI=1S/C42H46N4/c1-2-4-6-12-28-44-40-26-30-46(42-16-10-8-14-38(40)42)32-34-19-23-36(24-20-34)35-21-17-33(18-22-35)31-45-29-25-39(43-27-11-5-3-1)37-13-7-9-15-41(37)45/h7-10,13-26,29-30,43-44H,1-6,11-12,27-28,31-32H2/q+2	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...				J Med Chem 43: 420-31 (2000) Article DOI: 10.1021/jm9902537 BindingDB Entry DOI: 10.7270/Q21V5HQ2
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (Rattus norvegicus (Rat))	BDBM50084839 (Bis-quinolinium cyclophane analogue | CHEMBL6266 |...) Show SMILES C1CCCCCN[c+]2ccn(Cc3ccc(cc3)-c3ccc(Cn4cc[c+](NCCCC1)c1ccccc41)cc3)c1ccccc21 Show InChI InChI=1S/C42H46N4/c1-2-4-6-12-28-44-40-26-30-46(42-16-10-8-14-38(40)42)32-34-19-23-36(24-20-34)35-21-17-33(18-22-35)31-45-29-25-39(43-27-11-5-3-1)37-13-7-9-15-41(37)45/h7-10,13-26,29-30,43-44H,1-6,11-12,27-28,31-32H2/q+2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...				Bioorg Med Chem Lett 7: 7-10 (1997) Article DOI: 10.1016/S0960-894X(96)00568-9 BindingDB Entry DOI: 10.7270/Q22B8Z1R
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (Rattus norvegicus (Rat))	BDBM50084851 (Bis-quinolinium cyclophane analogue | CHEMBL266885...) Show SMILES C1CCCCCN[c+]2ccn(Cc3ccc(CCc4ccc(Cn5cc[c+](NCCCC1)c1ccccc51)cc4)cc3)c1ccccc21 Show InChI InChI=1S/C44H50N4/c1-2-4-6-12-30-46-42-28-32-48(44-16-10-8-14-40(42)44)34-38-25-21-36(22-26-38)18-17-35-19-23-37(24-20-35)33-47-31-27-41(45-29-11-5-3-1)39-13-7-9-15-43(39)47/h7-10,13-16,19-28,31-32,45-46H,1-6,11-12,17-18,29-30,33-34H2/q+2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...				Bioorg Med Chem Lett 7: 7-10 (1997) Article DOI: 10.1016/S0960-894X(96)00568-9 BindingDB Entry DOI: 10.7270/Q22B8Z1R
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50084851 (Bis-quinolinium cyclophane analogue | CHEMBL266885...) Show SMILES C1CCCCCN[c+]2ccn(Cc3ccc(CCc4ccc(Cn5cc[c+](NCCCC1)c1ccccc51)cc4)cc3)c1ccccc21 Show InChI InChI=1S/C44H50N4/c1-2-4-6-12-30-46-42-28-32-48(44-16-10-8-14-40(42)44)34-38-25-21-36(22-26-38)18-17-35-19-23-37(24-20-35)33-47-31-27-41(45-29-11-5-3-1)39-13-7-9-15-43(39)47/h7-10,13-16,19-28,31-32,45-46H,1-6,11-12,17-18,29-30,33-34H2/q+2	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...				J Med Chem 43: 420-31 (2000) Article DOI: 10.1021/jm9902537 BindingDB Entry DOI: 10.7270/Q21V5HQ2
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50474864 (CHEMBL119859) Show SMILES [I-].[I-].C1CCCCNc2cc[n+](CCCCCCCC[n+]3ccc(NCCC1)c1ccccc31)c1ccccc21 Show InChI InChI=1S/C34H44N4/c1-2-6-14-24-36-32-22-28-38(34-20-12-10-18-30(32)34)26-16-8-4-3-7-15-25-37-27-21-31(35-23-13-5-1)29-17-9-11-19-33(29)37/h9-12,17-22,27-28H,1-8,13-16,23-26H2/p+2/b35-31+,36-32?	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
Aristotelian University of Thessaloniki Curated by ChEMBL					Assay Description Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activity				Bioorg Med Chem Lett 14: 4231-5 (2004) Article DOI: 10.1016/j.bmcl.2004.06.011 BindingDB Entry DOI: 10.7270/Q2FF3W4T
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50054105 ((Z)-1.1'-[stilbene-4,4'-diylbis(methylene)]bis(4-a...) Show SMILES [NH2+]=c1ccn(Cc2ccc(\C=C/c3ccc(Cn4ccc(=[NH2+])c5ccccc45)cc3)cc2)c2ccccc12 Show InChI InChI=1S/C34H28N4/c35-31-19-21-37(33-7-3-1-5-29(31)33)23-27-15-11-25(12-16-27)9-10-26-13-17-28(18-14-26)24-38-22-20-32(36)30-6-2-4-8-34(30)38/h1-22,35-36H,23-24H2/p+2/b10-9-,35-31?,36-32?	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...				J Med Chem 43: 420-31 (2000) Article DOI: 10.1021/jm9902537 BindingDB Entry DOI: 10.7270/Q21V5HQ2
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (Rattus norvegicus (Rat))	BDBM50054105 ((Z)-1.1'-[stilbene-4,4'-diylbis(methylene)]bis(4-a...) Show SMILES [NH2+]=c1ccn(Cc2ccc(\C=C/c3ccc(Cn4ccc(=[NH2+])c5ccccc45)cc3)cc2)c2ccccc12 Show InChI InChI=1S/C34H28N4/c35-31-19-21-37(33-7-3-1-5-29(31)33)23-27-15-11-25(12-16-27)9-10-26-13-17-28(18-14-26)24-38-22-20-32(36)30-6-2-4-8-34(30)38/h1-22,35-36H,23-24H2/p+2/b10-9-,35-31?,36-32?	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...				Bioorg Med Chem Lett 7: 7-10 (1997) Article DOI: 10.1016/S0960-894X(96)00568-9 BindingDB Entry DOI: 10.7270/Q22B8Z1R
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50473108 (CHEMBL137116) Show SMILES C1CCCCC[n+]2ccc(NCc3ccc(cc3)-c3ccc(CNc4cc[n+](CCCC1)c1ccccc41)cc3)c1ccccc21 Show InChI InChI=1S/C42H44N4/c1-2-4-6-12-28-46-30-26-40(38-14-8-10-16-42(38)46)44-32-34-19-23-36(24-20-34)35-21-17-33(18-22-35)31-43-39-25-29-45(27-11-5-3-1)41-15-9-7-13-37(39)41/h7-10,13-26,29-30H,1-6,11-12,27-28,31-32H2/p+2/b43-39+,44-40+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...				J Med Chem 43: 420-31 (2000) Article DOI: 10.1021/jm9902537 BindingDB Entry DOI: 10.7270/Q21V5HQ2
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50473111 (CHEMBL137256) Show SMILES C1Nc2cc[n+](Cc3ccc(cc3)\C=C/c3ccc(C[n+]4ccc(NCc5ccc(Cc6ccc1cc6)cc5)c1ccccc41)cc3)c1ccccc21 |c:14| Show InChI InChI=1S/C49H40N4/c1-3-7-48-44(5-1)46-27-29-52(48)34-42-23-11-36(12-24-42)9-10-37-13-25-43(26-14-37)35-53-30-28-47(45-6-2-4-8-49(45)53)51-33-41-21-17-39(18-22-41)31-38-15-19-40(20-16-38)32-50-46/h1-30H,31-35H2/p+2/b10-9-,50-46+,51-47?	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...				J Med Chem 43: 420-31 (2000) Article DOI: 10.1021/jm9902537 BindingDB Entry DOI: 10.7270/Q21V5HQ2
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50473109 (CHEMBL136303) Show SMILES C1Nc2cc[n+](Cc3ccc(Cc4ccc(C[n+]5ccc(NCc6ccc(Cc7ccc1cc7)cc6)c1ccccc51)cc4)cc3)c1ccccc21 Show InChI InChI=1S/C48H40N4/c1-3-7-47-43(5-1)45-25-27-51(47)33-41-21-13-37(14-22-41)30-38-15-23-42(24-16-38)34-52-28-26-46(44-6-2-4-8-48(44)52)50-32-40-19-11-36(12-20-40)29-35-9-17-39(18-10-35)31-49-45/h1-28H,29-34H2/p+2/b49-45+,50-46+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...				J Med Chem 43: 420-31 (2000) Article DOI: 10.1021/jm9902537 BindingDB Entry DOI: 10.7270/Q21V5HQ2
					More data for this Ligand-Target Pair

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