Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Endothelin-1 receptor (Homo sapiens (Human)) | BDBM50045246 (Ac-D-Dip-Orn-Asp-Ile-Ile-Trp | CHEMBL2370066) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 13 | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description Effective concentration against ET A receptor from rabbit renal artery vascular smooth muscle cells | J Med Chem 36: 2585-94 (1993) BindingDB Entry DOI: 10.7270/Q2V69K6K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Endothelin-1 receptor (Homo sapiens (Human)) | BDBM50045264 (Ac-D-Dip-Leu-Asp-Val-Ile-Trp | CHEMBL315841) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 17 | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description Effective concentration against ET A receptor from rabbit renal artery vascular smooth muscle cells | J Med Chem 36: 2585-94 (1993) BindingDB Entry DOI: 10.7270/Q2V69K6K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Endothelin-1 receptor (Homo sapiens (Human)) | BDBM50045263 (Ac-D-Dip-Glu-Asp-Ile-Ile-Trp | CHEMBL407269) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 25 | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description Effective concentration against ET A receptor from rabbit renal artery vascular smooth muscle cells | J Med Chem 36: 2585-94 (1993) BindingDB Entry DOI: 10.7270/Q2V69K6K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Endothelin-1 receptor (Homo sapiens (Human)) | BDBM50045224 (Ac-D-Dip-Leu-Phe-Ile-Ile-Trp | CHEMBL387200) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 580 | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description Effective concentration against ET A receptor from rabbit renal artery vascular smooth muscle cells | J Med Chem 36: 2585-94 (1993) BindingDB Entry DOI: 10.7270/Q2V69K6K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Endothelin-1 receptor (Homo sapiens (Human)) | BDBM50045256 (CHEMBL2370067 | D-Dip-Leu-Asp-Ile-Ile-Trp) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description Effective concentration against ET A receptor from rabbit renal artery vascular smooth muscle cells | J Med Chem 36: 2585-94 (1993) BindingDB Entry DOI: 10.7270/Q2V69K6K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Endothelin-1 receptor (Homo sapiens (Human)) | BDBM50045234 (Ac-D-Dip-Leu-Asp-Ile-Ile-Tyr | CHEMBL313344) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description Effective concentration against ET A receptor from rabbit renal artery vascular smooth muscle cells | J Med Chem 36: 2585-94 (1993) BindingDB Entry DOI: 10.7270/Q2V69K6K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Endothelin-1 receptor (Homo sapiens (Human)) | BDBM50499310 (CHEMBL3736433) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | <5.01E+3 | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica N.V. Curated by ChEMBL | Assay Description Agonist activity at human wild-type ETA receptor expressed in CHO-K1 cells assessed as calcium level by HTRF assay | J Med Chem 58: 9287-95 (2015) Article DOI: 10.1021/acs.jmedchem.5b01088 BindingDB Entry DOI: 10.7270/Q21C20VP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Endothelin-1 receptor (Homo sapiens (Human)) | BDBM25761 (Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | <5.01E+3 | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica N.V. Curated by ChEMBL | Assay Description Agonist activity at human wild-type ETA receptor expressed in CHO-K1 cells assessed as calcium level by HTRF assay | J Med Chem 58: 9287-95 (2015) Article DOI: 10.1021/acs.jmedchem.5b01088 BindingDB Entry DOI: 10.7270/Q21C20VP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Endothelin-1 receptor (Homo sapiens (Human)) | BDBM50499311 (CHEMBL3736156) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | <5.01E+3 | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica N.V. Curated by ChEMBL | Assay Description Agonist activity at human wild-type ETA receptor expressed in CHO-K1 cells assessed as calcium level by HTRF assay | J Med Chem 58: 9287-95 (2015) Article DOI: 10.1021/acs.jmedchem.5b01088 BindingDB Entry DOI: 10.7270/Q21C20VP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Endothelin-1 receptor (Homo sapiens (Human)) | BDBM50045249 (Ac-D-Dip-Leu-Asp-Ile-Val-Trp | CHEMBL86703) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description Effective concentration against ET A receptor from rabbit renal artery vascular smooth muscle cells | J Med Chem 36: 2585-94 (1993) BindingDB Entry DOI: 10.7270/Q2V69K6K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Endothelin-1 receptor (Homo sapiens (Human)) | BDBM50516235 (CHEMBL4563408) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
RTI International Curated by ChEMBL | Assay Description Displacement of [125I]endothelin-1 from recombinant human ETA receptor after 120 mins by scintillation counting analysis | J Med Chem 62: 6330-6345 (2019) Article DOI: 10.1021/acs.jmedchem.9b00727 BindingDB Entry DOI: 10.7270/Q24F1V3D | |||||||||||
More data for this Ligand-Target Pair |