Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Glutamate receptor 1 (Homo sapiens (Human)) | BDBM426302 (6-(7-Morpholino-2-phenyl-pyrazolo[1,5-c]pyrimidin-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.0500 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv... | US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor 1 (Homo sapiens (Human)) | BDBM426273 (6-[7-(4-Methoxy-1-piperidyl)-2-phenyl-pyrazolo[1,5...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.0600 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv... | US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor 1 (Homo sapiens (Human)) | BDBM426136 (5-[8-(4-Fluoro-1-piperidyl)-2-phenyl-imidazo[1,2-a...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.0600 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv... | US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor 1 (Homo sapiens (Human)) | BDBM426170 (5-(2-(4-Fluorophenyl)-8-(4-oxopiperidin-1-yl)imida...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.0600 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv... | US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor 1 (Homo sapiens (Human)) | BDBM426135 (5-[2-(4-Fluorophenyl)-8-(4-fluoro-1-piperidyl)imid...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.0800 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv... | US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor 1 (Homo sapiens (Human)) | BDBM426234 (5-[2-(4-Fluorophenyl)-7-(4-oxo-1-piperidyl)pyrazol...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.0800 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv... | US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor 1 (Homo sapiens (Human)) | BDBM426272 (4-[3-(1H-Indazol-5-yl)-4-methyl-2-phenyl-pyrazolo[...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.0800 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv... | US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor 1/Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human)) | BDBM426135 (5-[2-(4-Fluorophenyl)-8-(4-fluoro-1-piperidyl)imid...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanford Burnham Prebys Medical Discovery Institute Curated by ChEMBL | Assay Description Negative allosteric modulation of recombinant human GluA1 flop isoform/TARPgamma2 expressed in HEK293 cells assessed as inhibition of glutamate-induc... | ACS Med Chem Lett 10: 267-272 (2019) Article DOI: 10.1021/acsmedchemlett.8b00599 BindingDB Entry DOI: 10.7270/Q26H4MRG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor 1 (Homo sapiens (Human)) | BDBM426129 (5-[2-(4-Fluorophenyl)-8-(4-hydroxy-4-methyl-1-pipe...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv... | US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor 1/Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human)) | BDBM426135 (5-[2-(4-Fluorophenyl)-8-(4-fluoro-1-piperidyl)imid...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanford Burnham Prebys Medical Discovery Institute Curated by ChEMBL | Assay Description Negative allosteric modulation of recombinant human GluA1 flop isoform/TARPgamma2 expressed in HEK293 cells assessed as inhibition of glutamate-induc... | ACS Med Chem Lett 10: 267-272 (2019) Article DOI: 10.1021/acsmedchemlett.8b00599 BindingDB Entry DOI: 10.7270/Q26H4MRG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor 1 (Homo sapiens (Human)) | BDBM426133 (5-[2-(4-Fluorophenyl)-8-(4-methoxy-1-piperidyl)imi...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.130 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv... | US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor 1 (Homo sapiens (Human)) | BDBM426268 (5-(4-Methyl-7-morpholino-2-phenyl-pyrazolo[1,5-c]p...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.130 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv... | US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor 1 (Homo sapiens (Human)) | BDBM426223 (5-[5-Chloro-2-(4-fluorophenyl)-8-morpholino-imidaz...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.130 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv... | US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor 1 (Homo sapiens (Human)) | BDBM426126 (5-(8-Morpholino-2-phenyl-imidazo[1,2-a]pyrazin-3-y...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.160 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv... | US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor 1 (Homo sapiens (Human)) | BDBM426131 ((trans)-5-[8-(3-Fluoro-4-hydroxy-1-piperidyl)-2-(4...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.160 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv... | US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor 1 (Homo sapiens (Human)) | BDBM426249 (5-[7-(4-Methoxy-1-piperidyl)-2-phenyl-pyrazolo[1,5...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.160 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv... | US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor 1 (Homo sapiens (Human)) | BDBM426245 (5-(2-(4-Fluorophenyl)-8-(1,2,6-triazaspiro[2;5]oct...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.160 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv... | US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor 1 (Homo sapiens (Human)) | BDBM426247 (5-[7-(4-Hydroxy-1-piperidyl)-2-phenyl-pyrazolo[1,5...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.160 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv... | US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor 1 (Homo sapiens (Human)) | BDBM426232 (5-[7-(4-Acetylpiperazin-1-yl)-2-(4-fluorophenyl)py...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.160 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv... | US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor 1/Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human)) | BDBM50459036 (CHEMBL4211865) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research & Development L.L.C. Curated by ChEMBL | Assay Description Modulation of recombinant human GluA1 flop isoform/TARPgamma8 expressed in HEK293F cells assessed as blockade of glutamate-induced calcium flux by ca... | ACS Med Chem Lett 9: 821-826 (2018) Article DOI: 10.1021/acsmedchemlett.8b00215 BindingDB Entry DOI: 10.7270/Q2ZW1PJ3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor 1/Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human)) | BDBM426226 (5-[2-(4-Fluorophenyl)-7-(4-hydroxy-1-piperidyl)pyr...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanford Burnham Prebys Medical Discovery Institute Curated by ChEMBL | Assay Description Negative allosteric modulation of recombinant human GluA1 flop isoform/TARPgamma2 expressed in HEK293 cells assessed as inhibition of glutamate-induc... | ACS Med Chem Lett 10: 267-272 (2019) Article DOI: 10.1021/acsmedchemlett.8b00599 BindingDB Entry DOI: 10.7270/Q26H4MRG | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Glutamate receptor 1 (Homo sapiens (Human)) | BDBM426074 (1-[4-[2-(4-Fluorophenyl)-3-(1H-indazol-5-yl)imidaz...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv... | US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor 1 (Homo sapiens (Human)) | BDBM426094 (4-[2-(4-Fluorophenyl)-3-(1H-indazol-5-yl)imidazo[1...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv... | US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor 1 (Homo sapiens (Human)) | BDBM426116 (5-[8-(1,4-Dioxa-8-azaspiro[4;5]decan-8-yl)-2-(4- |...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv... | US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor 1 (Homo sapiens (Human)) | BDBM426250 (5-[2-(4-Fluorophenyl)-7-(4-fluoro-1-piperidyl)pyra...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv... | US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor 1 (Homo sapiens (Human)) | BDBM426226 (5-[2-(4-Fluorophenyl)-7-(4-hydroxy-1-piperidyl)pyr...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | PDB US Patent | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv... | US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Glutamate receptor 1 (Homo sapiens (Human)) | BDBM426237 (5-[2-(4-Fluorophenyl)-7-(3-methylmorpholin-4-yl)py...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv... | US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor 1 (Homo sapiens (Human)) | BDBM426246 (5-[2-(4-Fluorophenyl)-7-(4-hydroxy-4-methyl-1-pipe...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv... | US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor 1 (Homo sapiens (Human)) | BDBM426069 (5-[2-(4-Fluorophenyl)-8-morpholino-imidazo[1,2-a]p...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv... | US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor 1 (Homo sapiens (Human)) | BDBM426132 (5-[8-(3,3-Difluoro-4-hydroxy-1-piperidyl)-2-(4-flu...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.25 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv... | US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor 1 (Homo sapiens (Human)) | BDBM426137 (5-[8-[4-(Fluoromethyl)-1-piperidyl]-2-phenyl-imida...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.25 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv... | US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor 1/Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human)) | BDBM426232 (5-[7-(4-Acetylpiperazin-1-yl)-2-(4-fluorophenyl)py...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.251 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanford Burnham Prebys Medical Discovery Institute Curated by ChEMBL | Assay Description Negative allosteric modulation of recombinant human GluA1 flop isoform/TARPgamma2 expressed in HEK293 cells assessed as inhibition of glutamate-induc... | ACS Med Chem Lett 10: 267-272 (2019) Article DOI: 10.1021/acsmedchemlett.8b00599 BindingDB Entry DOI: 10.7270/Q26H4MRG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor 1 (Homo sapiens (Human)) | BDBM426097 (US10513523, Example 36 | tert-Butyl 4-[2-benzyl-3-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.320 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv... | US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor 1 (Homo sapiens (Human)) | BDBM426098 (5-[2-(4-Fluorophenyl)-8-(4-hydroxy-1-piperidyl)imi...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.320 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv... | US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor 1 (Homo sapiens (Human)) | BDBM426115 (5-[2-(4-Fluorophenyl)-8-(3-hydroxy-1-piperidyl)imi...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.320 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv... | US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor 1 (Homo sapiens (Human)) | BDBM426134 ((cis)-5-[8-(3-Fluoro-4-hydroxy-1-piperidyl)-2-(4- ...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.320 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv... | US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor 1 (Homo sapiens (Human)) | BDBM426253 (US10513523, Example 193 | trans-5-[7-(3-Fluoro-4-h...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.320 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv... | US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor 1 (Homo sapiens (Human)) | BDBM426174 (5-(8-(4-Acetylpiperazin-1-yl)-2-benzyl-5-bromoimid...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.320 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv... | US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor 1 (Homo sapiens (Human)) | BDBM426178 (6-[2-(4-Fluorophenyl)-8-morpholino-imidazo[1,2-a]p...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.320 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv... | US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor 1 (Homo sapiens (Human)) | BDBM426213 (5-(2-Benzoyl-8-morpholino-imidazo[1,2-a]pyrazin-3-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.320 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv... | US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor 1 (Homo sapiens (Human)) | BDBM426143 (5-[5-Chloro-2-(4-fluorophenyl)-8-morpholino-imidaz...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.320 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv... | US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor 1/Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human)) | BDBM426073 (5-[8-(4-Acetylpiperazin-1-yl)-2-(4-fluorophenyl)im...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.398 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanford Burnham Prebys Medical Discovery Institute Curated by ChEMBL | Assay Description Negative allosteric modulation of recombinant human GluA1 flop isoform/TARPgamma2 expressed in HEK293 cells assessed as inhibition of glutamate-induc... | ACS Med Chem Lett 10: 267-272 (2019) Article DOI: 10.1021/acsmedchemlett.8b00599 BindingDB Entry DOI: 10.7270/Q26H4MRG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor 1/Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human)) | BDBM426098 (5-[2-(4-Fluorophenyl)-8-(4-hydroxy-1-piperidyl)imi...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.398 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanford Burnham Prebys Medical Discovery Institute Curated by ChEMBL | Assay Description Negative allosteric modulation of recombinant human GluA1 flop isoform/TARPgamma2 expressed in HEK293 cells assessed as inhibition of glutamate-induc... | ACS Med Chem Lett 10: 267-272 (2019) Article DOI: 10.1021/acsmedchemlett.8b00599 BindingDB Entry DOI: 10.7270/Q26H4MRG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor 1 (Homo sapiens (Human)) | BDBM426072 (5-[2-(4-Fluorophenyl)-8-morpholino-imidazo[1,2-a]p...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv... | US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor 1 (Homo sapiens (Human)) | BDBM426073 (5-[8-(4-Acetylpiperazin-1-yl)-2-(4-fluorophenyl)im...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv... | US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor 1 (Homo sapiens (Human)) | BDBM426108 (5-[8-(1,1-Dioxo-1,4-thiazinan-4-yl)-2-(4-fluorophe...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv... | US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor 1 (Homo sapiens (Human)) | BDBM426293 (4-[3-(1H-Indazol-5-yl)-2-phenyl-pyrazolo[1,5-c]pyr...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv... | US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor 1 (Homo sapiens (Human)) | BDBM426142 (5-[8-(3-Fluoroazetidin-1-yl)-2-phenyl-imidazo[1,2-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv... | US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor 1 (Homo sapiens (Human)) | BDBM426267 (5-(4-Bromo-7-morpholino-2-phenyl-pyrazolo[1,5-c]py...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv... | US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor 1 (Homo sapiens (Human)) | BDBM426138 (5-[8-[4-(2-Fluoroethyl)-1-piperidyl]-2-phenyl-imid...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv... | US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR | |||||||||||
More data for this Ligand-Target Pair |
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