Compile Data Set for Download or QSAR

Found 307 hits of ic50 for UniProtKB: P42261   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glutamate receptor 1 (Homo sapiens (Human))	BDBM426302 (6-(7-Morpholino-2-phenyl-pyrazolo[1,5-c]pyrimidin-...) Show SMILES O=c1[nH]c2ccc(cc2s1)-c1c(nn2c(nccc12)N1CCOCC1)-c1ccccc1 Show InChI InChI=1S/C23H19N5O2S/c29-23-25-17-7-6-16(14-19(17)31-23)20-18-8-9-24-22(27-10-12-30-13-11-27)28(18)26-21(20)15-4-2-1-3-5-15/h1-9,14H,10-13H2,(H,25,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0500	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR
					More data for this Ligand-Target Pair
Glutamate receptor 1 (Homo sapiens (Human))	BDBM426170 (5-(2-(4-Fluorophenyl)-8-(4-oxopiperidin-1-yl)imida...) Show SMILES Fc1ccc(cc1)-c1nc2c(nccn2c1-c1ccc2NC(=O)Cc2c1)N1CCC(=O)CC1 Show InChI InChI=1S/C25H20FN5O2/c26-18-4-1-15(2-5-18)22-23(16-3-6-20-17(13-16)14-21(33)28-20)31-12-9-27-24(25(31)29-22)30-10-7-19(32)8-11-30/h1-6,9,12-13H,7-8,10-11,14H2,(H,28,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0600	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR
					More data for this Ligand-Target Pair
Glutamate receptor 1 (Homo sapiens (Human))	BDBM426273 (6-[7-(4-Methoxy-1-piperidyl)-2-phenyl-pyrazolo[1,5...) Show SMILES COC1CCN(CC1)c1nccc2c(c(nn12)-c1ccccc1)-c1ccc2[nH]c(=O)sc2c1 Show InChI InChI=1S/C25H23N5O2S/c1-32-18-10-13-29(14-11-18)24-26-12-9-20-22(17-7-8-19-21(15-17)33-25(31)27-19)23(28-30(20)24)16-5-3-2-4-6-16/h2-9,12,15,18H,10-11,13-14H2,1H3,(H,27,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0600	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR
					More data for this Ligand-Target Pair
Glutamate receptor 1 (Homo sapiens (Human))	BDBM426136 (5-[8-(4-Fluoro-1-piperidyl)-2-phenyl-imidazo[1,2-a...) Show SMILES FC1CCN(CC1)c1nccn2c(c(nc12)-c1ccccc1)-c1ccc2NC(=O)Cc2c1 Show InChI InChI=1S/C25H22FN5O/c26-19-8-11-30(12-9-19)24-25-29-22(16-4-2-1-3-5-16)23(31(25)13-10-27-24)17-6-7-20-18(14-17)15-21(32)28-20/h1-7,10,13-14,19H,8-9,11-12,15H2,(H,28,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0600	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR
					More data for this Ligand-Target Pair
Glutamate receptor 1 (Homo sapiens (Human))	BDBM426135 (5-[2-(4-Fluorophenyl)-8-(4-fluoro-1-piperidyl)imid...) Show SMILES FC1CCN(CC1)c1nccn2c(c(nc12)-c1ccc(F)cc1)-c1ccc2NC(=O)Cc2c1 Show InChI InChI=1S/C25H21F2N5O/c26-18-4-1-15(2-5-18)22-23(16-3-6-20-17(13-16)14-21(33)29-20)32-12-9-28-24(25(32)30-22)31-10-7-19(27)8-11-31/h1-6,9,12-13,19H,7-8,10-11,14H2,(H,29,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0800	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR
					More data for this Ligand-Target Pair
Glutamate receptor 1 (Homo sapiens (Human))	BDBM426272 (4-[3-(1H-Indazol-5-yl)-4-methyl-2-phenyl-pyrazolo[...) Show SMILES Cc1cnc(N2CCOCC2)n2nc(c(-c3ccc4[nH]ncc4c3)c12)-c1ccccc1 Show InChI InChI=1S/C24H22N6O/c1-16-14-25-24(29-9-11-31-12-10-29)30-23(16)21(22(28-30)17-5-3-2-4-6-17)18-7-8-20-19(13-18)15-26-27-20/h2-8,13-15H,9-12H2,1H3,(H,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0800	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR
					More data for this Ligand-Target Pair
Glutamate receptor 1 (Homo sapiens (Human))	BDBM426234 (5-[2-(4-Fluorophenyl)-7-(4-oxo-1-piperidyl)pyrazol...) Show SMILES Fc1ccc(cc1)-c1nn2c(nccc2c1-c1ccc2NC(=O)Cc2c1)N1CCC(=O)CC1 Show InChI InChI=1S/C25H20FN5O2/c26-18-4-1-15(2-5-18)24-23(16-3-6-20-17(13-16)14-22(33)28-20)21-7-10-27-25(31(21)29-24)30-11-8-19(32)9-12-30/h1-7,10,13H,8-9,11-12,14H2,(H,28,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0800	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR
					More data for this Ligand-Target Pair
Glutamate receptor 1 (Homo sapiens (Human))	BDBM426129 (5-[2-(4-Fluorophenyl)-8-(4-hydroxy-4-methyl-1-pipe...) Show SMILES CC1(O)CCN(CC1)c1nccn2c(c(nc12)-c1ccc(F)cc1)-c1ccc2NC(=O)Cc2c1 Show InChI InChI=1S/C26H24FN5O2/c1-26(34)8-11-31(12-9-26)24-25-30-22(16-2-5-19(27)6-3-16)23(32(25)13-10-28-24)17-4-7-20-18(14-17)15-21(33)29-20/h2-7,10,13-14,34H,8-9,11-12,15H2,1H3,(H,29,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR
					More data for this Ligand-Target Pair
Glutamate receptor 1 (Homo sapiens (Human))	BDBM426268 (5-(4-Methyl-7-morpholino-2-phenyl-pyrazolo[1,5-c]p...) Show SMILES Cc1cnc(N2CCOCC2)n2nc(c(-c3ccc4NC(=O)Cc4c3)c12)-c1ccccc1 Show InChI InChI=1S/C25H23N5O2/c1-16-15-26-25(29-9-11-32-12-10-29)30-24(16)22(23(28-30)17-5-3-2-4-6-17)18-7-8-20-19(13-18)14-21(31)27-20/h2-8,13,15H,9-12,14H2,1H3,(H,27,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.130	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR
					More data for this Ligand-Target Pair
Glutamate receptor 1 (Homo sapiens (Human))	BDBM426223 (5-[5-Chloro-2-(4-fluorophenyl)-8-morpholino-imidaz...) Show SMILES Fc1ccc(cc1)-c1nc2c(ncc(Cl)n2c1-c1ccc2NC(=O)Cc2c1)N1CCOCC1 Show InChI InChI=1S/C24H19ClFN5O2/c25-19-13-27-23(30-7-9-33-10-8-30)24-29-21(14-1-4-17(26)5-2-14)22(31(19)24)15-3-6-18-16(11-15)12-20(32)28-18/h1-6,11,13H,7-10,12H2,(H,28,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.130	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR
					More data for this Ligand-Target Pair
Glutamate receptor 1 (Homo sapiens (Human))	BDBM426133 (5-[2-(4-Fluorophenyl)-8-(4-methoxy-1-piperidyl)imi...) Show SMILES COC1CCN(CC1)c1nccn2c(c(nc12)-c1ccc(F)cc1)-c1ccc2NC(=O)Cc2c1 Show InChI InChI=1S/C26H24FN5O2/c1-34-20-8-11-31(12-9-20)25-26-30-23(16-2-5-19(27)6-3-16)24(32(26)13-10-28-25)17-4-7-21-18(14-17)15-22(33)29-21/h2-7,10,13-14,20H,8-9,11-12,15H2,1H3,(H,29,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.130	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR
					More data for this Ligand-Target Pair
Glutamate receptor 1 (Homo sapiens (Human))	BDBM426247 (5-[7-(4-Hydroxy-1-piperidyl)-2-phenyl-pyrazolo[1,5...) Show SMILES OC1CCN(CC1)c1nccc2c(c(nn12)-c1ccccc1)-c1ccc2NC(=O)Cc2c1 Show InChI InChI=1S/C25H23N5O2/c31-19-9-12-29(13-10-19)25-26-11-8-21-23(17-6-7-20-18(14-17)15-22(32)27-20)24(28-30(21)25)16-4-2-1-3-5-16/h1-8,11,14,19,31H,9-10,12-13,15H2,(H,27,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.160	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR
					More data for this Ligand-Target Pair
Glutamate receptor 1 (Homo sapiens (Human))	BDBM426249 (5-[7-(4-Methoxy-1-piperidyl)-2-phenyl-pyrazolo[1,5...) Show SMILES COC1CCN(CC1)c1nccc2c(c(nn12)-c1ccccc1)-c1ccc2NC(=O)Cc2c1 Show InChI InChI=1S/C26H25N5O2/c1-33-20-10-13-30(14-11-20)26-27-12-9-22-24(18-7-8-21-19(15-18)16-23(32)28-21)25(29-31(22)26)17-5-3-2-4-6-17/h2-9,12,15,20H,10-11,13-14,16H2,1H3,(H,28,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.160	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR
					More data for this Ligand-Target Pair
Glutamate receptor 1 (Homo sapiens (Human))	BDBM426245 (5-(2-(4-Fluorophenyl)-8-(1,2,6-triazaspiro[2;5]oct...) Show SMILES Fc1ccc(cc1)-c1nc2c(nccn2c1-c1ccc2NC(=O)Cc2c1)N1CCC2(CC1)N=N2 |c:38| Show InChI InChI=1S/C25H20FN7O/c26-18-4-1-15(2-5-18)21-22(16-3-6-19-17(13-16)14-20(34)28-19)33-12-9-27-23(24(33)29-21)32-10-7-25(8-11-32)30-31-25/h1-6,9,12-13H,7-8,10-11,14H2,(H,28,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.160	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR
					More data for this Ligand-Target Pair
Glutamate receptor 1 (Homo sapiens (Human))	BDBM426232 (5-[7-(4-Acetylpiperazin-1-yl)-2-(4-fluorophenyl)py...) Show SMILES CC(=O)N1CCN(CC1)c1nccc2c(c(nn12)-c1ccc(F)cc1)-c1ccc2NC(=O)Cc2c1 Show InChI InChI=1S/C26H23FN6O2/c1-16(34)31-10-12-32(13-11-31)26-28-9-8-22-24(18-4-7-21-19(14-18)15-23(35)29-21)25(30-33(22)26)17-2-5-20(27)6-3-17/h2-9,14H,10-13,15H2,1H3,(H,29,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.160	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR
					More data for this Ligand-Target Pair
Glutamate receptor 1 (Homo sapiens (Human))	BDBM426131 ((trans)-5-[8-(3-Fluoro-4-hydroxy-1-piperidyl)-2-(4...) Show SMILES O[C@@H]1CCN(C[C@H]1F)c1nccn2c(c(nc12)-c1ccc(F)cc1)-c1ccc2NC(=O)Cc2c1 |r| Show InChI InChI=1S/C25H21F2N5O2/c26-17-4-1-14(2-5-17)22-23(15-3-6-19-16(11-15)12-21(34)29-19)32-10-8-28-24(25(32)30-22)31-9-7-20(33)18(27)13-31/h1-6,8,10-11,18,20,33H,7,9,12-13H2,(H,29,34)/t18-,20-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.160	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR
					More data for this Ligand-Target Pair
Glutamate receptor 1 (Homo sapiens (Human))	BDBM426126 (5-(8-Morpholino-2-phenyl-imidazo[1,2-a]pyrazin-3-y...) Show SMILES O=C1Cc2cc(ccc2N1)-c1c(nc2c(nccn12)N1CCOCC1)-c1ccccc1 Show InChI InChI=1S/C24H21N5O2/c30-20-15-18-14-17(6-7-19(18)26-20)22-21(16-4-2-1-3-5-16)27-24-23(25-8-9-29(22)24)28-10-12-31-13-11-28/h1-9,14H,10-13,15H2,(H,26,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.160	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR
					More data for this Ligand-Target Pair
Glutamate receptor 1 (Homo sapiens (Human))	BDBM426226 (5-[2-(4-Fluorophenyl)-7-(4-hydroxy-1-piperidyl)pyr...) Show SMILES OC1CCN(CC1)c1nccc2c(c(nn12)-c1ccc(F)cc1)-c1ccc2NC(=O)Cc2c1 Show InChI InChI=1S/C25H22FN5O2/c26-18-4-1-15(2-5-18)24-23(16-3-6-20-17(13-16)14-22(33)28-20)21-7-10-27-25(31(21)29-24)30-11-8-19(32)9-12-30/h1-7,10,13,19,32H,8-9,11-12,14H2,(H,28,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR
					More data for this Ligand-Target Pair				3D Structure (crystal)
Glutamate receptor 1 (Homo sapiens (Human))	BDBM426069 (5-[2-(4-Fluorophenyl)-8-morpholino-imidazo[1,2-a]p...) Show SMILES Fc1ccc(cc1)-c1nc2c(nccn2c1-c1ccc2NC(=O)Cc2c1)N1CCOCC1 Show InChI InChI=1S/C24H20FN5O2/c25-18-4-1-15(2-5-18)21-22(16-3-6-19-17(13-16)14-20(31)27-19)30-8-7-26-23(24(30)28-21)29-9-11-32-12-10-29/h1-8,13H,9-12,14H2,(H,27,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR
					More data for this Ligand-Target Pair
Glutamate receptor 1 (Homo sapiens (Human))	BDBM426074 (1-[4-[2-(4-Fluorophenyl)-3-(1H-indazol-5-yl)imidaz...) Show SMILES CC(=O)N1CCN(CC1)c1nccn2c(c(nc12)-c1ccc(F)cc1)-c1ccc2[nH]ncc2c1 Show InChI InChI=1S/C25H22FN7O/c1-16(34)31-10-12-32(13-11-31)24-25-29-22(17-2-5-20(26)6-3-17)23(33(25)9-8-27-24)18-4-7-21-19(14-18)15-28-30-21/h2-9,14-15H,10-13H2,1H3,(H,28,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR
					More data for this Ligand-Target Pair
Glutamate receptor 1 (Homo sapiens (Human))	BDBM426116 (5-[8-(1,4-Dioxa-8-azaspiro[4;5]decan-8-yl)-2-(4- |...) Show SMILES Fc1ccc(cc1)-c1nc2c(nccn2c1-c1ccc2NC(=O)Cc2c1)N1CCC2(CC1)OCCO2 Show InChI InChI=1S/C27H24FN5O3/c28-20-4-1-17(2-5-20)23-24(18-3-6-21-19(15-18)16-22(34)30-21)33-12-9-29-25(26(33)31-23)32-10-7-27(8-11-32)35-13-14-36-27/h1-6,9,12,15H,7-8,10-11,13-14,16H2,(H,30,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR
					More data for this Ligand-Target Pair
Glutamate receptor 1 (Homo sapiens (Human))	BDBM426237 (5-[2-(4-Fluorophenyl)-7-(3-methylmorpholin-4-yl)py...) Show SMILES CC1COCCN1c1nccc2c(c(nn12)-c1ccc(F)cc1)-c1ccc2NC(=O)Cc2c1 Show InChI InChI=1S/C25H22FN5O2/c1-15-14-33-11-10-30(15)25-27-9-8-21-23(17-4-7-20-18(12-17)13-22(32)28-20)24(29-31(21)25)16-2-5-19(26)6-3-16/h2-9,12,15H,10-11,13-14H2,1H3,(H,28,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR
					More data for this Ligand-Target Pair
Glutamate receptor 1 (Homo sapiens (Human))	BDBM426246 (5-[2-(4-Fluorophenyl)-7-(4-hydroxy-4-methyl-1-pipe...) Show SMILES CC1(O)CCN(CC1)c1nccc2c(c(nn12)-c1ccc(F)cc1)-c1ccc2NC(=O)Cc2c1 Show InChI InChI=1S/C26H24FN5O2/c1-26(34)9-12-31(13-10-26)25-28-11-8-21-23(17-4-7-20-18(14-17)15-22(33)29-20)24(30-32(21)25)16-2-5-19(27)6-3-16/h2-8,11,14,34H,9-10,12-13,15H2,1H3,(H,29,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR
					More data for this Ligand-Target Pair
Glutamate receptor 1 (Homo sapiens (Human))	BDBM426250 (5-[2-(4-Fluorophenyl)-7-(4-fluoro-1-piperidyl)pyra...) Show SMILES FC1CCN(CC1)c1nccc2c(c(nn12)-c1ccc(F)cc1)-c1ccc2NC(=O)Cc2c1 Show InChI InChI=1S/C25H21F2N5O/c26-18-4-1-15(2-5-18)24-23(16-3-6-20-17(13-16)14-22(33)29-20)21-7-10-28-25(32(21)30-24)31-11-8-19(27)9-12-31/h1-7,10,13,19H,8-9,11-12,14H2,(H,29,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR
					More data for this Ligand-Target Pair
Glutamate receptor 1 (Homo sapiens (Human))	BDBM426094 (4-[2-(4-Fluorophenyl)-3-(1H-indazol-5-yl)imidazo[1...) Show SMILES Fc1ccc(cc1)-c1nc2c(nccn2c1-c1ccc2[nH]ncc2c1)N1CCNC(=O)C1 Show InChI InChI=1S/C23H18FN7O/c24-17-4-1-14(2-5-17)20-21(15-3-6-18-16(11-15)12-27-29-18)31-10-8-26-22(23(31)28-20)30-9-7-25-19(32)13-30/h1-6,8,10-12H,7,9,13H2,(H,25,32)(H,27,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR
					More data for this Ligand-Target Pair
Glutamate receptor 1 (Homo sapiens (Human))	BDBM426132 (5-[8-(3,3-Difluoro-4-hydroxy-1-piperidyl)-2-(4-flu...) Show SMILES OC1CCN(CC1(F)F)c1nccn2c(c(nc12)-c1ccc(F)cc1)-c1ccc2NC(=O)Cc2c1 Show InChI InChI=1S/C25H20F3N5O2/c26-17-4-1-14(2-5-17)21-22(15-3-6-18-16(11-15)12-20(35)30-18)33-10-8-29-23(24(33)31-21)32-9-7-19(34)25(27,28)13-32/h1-6,8,10-11,19,34H,7,9,12-13H2,(H,30,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.25	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR
					More data for this Ligand-Target Pair
Glutamate receptor 1 (Homo sapiens (Human))	BDBM426137 (5-[8-[4-(Fluoromethyl)-1-piperidyl]-2-phenyl-imida...) Show SMILES FCC1CCN(CC1)c1nccn2c(c(nc12)-c1ccccc1)-c1ccc2NC(=O)Cc2c1 Show InChI InChI=1S/C26H24FN5O/c27-16-17-8-11-31(12-9-17)25-26-30-23(18-4-2-1-3-5-18)24(32(26)13-10-28-25)19-6-7-21-20(14-19)15-22(33)29-21/h1-7,10,13-14,17H,8-9,11-12,15-16H2,(H,29,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.25	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR
					More data for this Ligand-Target Pair
Glutamate receptor 1 (Homo sapiens (Human))	BDBM426134 ((cis)-5-[8-(3-Fluoro-4-hydroxy-1-piperidyl)-2-(4- ...) Show SMILES O[C@H]1CCN(C[C@H]1F)c1nccn2c(c(nc12)-c1ccc(F)cc1)-c1ccc2NC(=O)Cc2c1 |r| Show InChI InChI=1S/C25H21F2N5O2/c26-17-4-1-14(2-5-17)22-23(15-3-6-19-16(11-15)12-21(34)29-19)32-10-8-28-24(25(32)30-22)31-9-7-20(33)18(27)13-31/h1-6,8,10-11,18,20,33H,7,9,12-13H2,(H,29,34)/t18-,20+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.320	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR
					More data for this Ligand-Target Pair
Glutamate receptor 1 (Homo sapiens (Human))	BDBM426097 (US10513523, Example 36 | tert-Butyl 4-[2-benzyl-3-...) Show SMILES CC(C)(C)OC(=O)N1CCN(CC1)c1nccn2c(c(Cc3ccccc3)nc12)-c1ccc2NC(=O)Cc2c1 Show InChI InChI=1S/C30H32N6O3/c1-30(2,3)39-29(38)35-15-13-34(14-16-35)27-28-33-24(17-20-7-5-4-6-8-20)26(36(28)12-11-31-27)21-9-10-23-22(18-21)19-25(37)32-23/h4-12,18H,13-17,19H2,1-3H3,(H,32,37)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.320	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR
					More data for this Ligand-Target Pair
Glutamate receptor 1 (Homo sapiens (Human))	BDBM426143 (5-[5-Chloro-2-(4-fluorophenyl)-8-morpholino-imidaz...) Show SMILES Fc1ccc(cc1)-c1nc2c(ncc(Cl)n2c1-c1ccc2[nH]c(=O)[nH]c2c1)N1CCOCC1 Show InChI InChI=1S/C23H18ClFN6O2/c24-18-12-26-21(30-7-9-33-10-8-30)22-29-19(13-1-4-15(25)5-2-13)20(31(18)22)14-3-6-16-17(11-14)28-23(32)27-16/h1-6,11-12H,7-10H2,(H2,27,28,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.320	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR
					More data for this Ligand-Target Pair
Glutamate receptor 1 (Homo sapiens (Human))	BDBM426098 (5-[2-(4-Fluorophenyl)-8-(4-hydroxy-1-piperidyl)imi...) Show SMILES OC1CCN(CC1)c1nccn2c(c(nc12)-c1ccc(F)cc1)-c1ccc2NC(=O)Cc2c1 Show InChI InChI=1S/C25H22FN5O2/c26-18-4-1-15(2-5-18)22-23(16-3-6-20-17(13-16)14-21(33)28-20)31-12-9-27-24(25(31)29-22)30-10-7-19(32)8-11-30/h1-6,9,12-13,19,32H,7-8,10-11,14H2,(H,28,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.320	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR
					More data for this Ligand-Target Pair
Glutamate receptor 1 (Homo sapiens (Human))	BDBM426115 (5-[2-(4-Fluorophenyl)-8-(3-hydroxy-1-piperidyl)imi...) Show SMILES OC1CCCN(C1)c1nccn2c(c(nc12)-c1ccc(F)cc1)-c1ccc2NC(=O)Cc2c1 Show InChI InChI=1S/C25H22FN5O2/c26-18-6-3-15(4-7-18)22-23(16-5-8-20-17(12-16)13-21(33)28-20)31-11-9-27-24(25(31)29-22)30-10-1-2-19(32)14-30/h3-9,11-12,19,32H,1-2,10,13-14H2,(H,28,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.320	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR
					More data for this Ligand-Target Pair
Glutamate receptor 1 (Homo sapiens (Human))	BDBM426213 (5-(2-Benzoyl-8-morpholino-imidazo[1,2-a]pyrazin-3-...) Show SMILES O=C(c1nc2c(nccn2c1-c1ccc2NC(=O)Cc2c1)N1CCOCC1)c1ccccc1 Show InChI InChI=1S/C25H21N5O3/c31-20-15-18-14-17(6-7-19(18)27-20)22-21(23(32)16-4-2-1-3-5-16)28-25-24(26-8-9-30(22)25)29-10-12-33-13-11-29/h1-9,14H,10-13,15H2,(H,27,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.320	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR
					More data for this Ligand-Target Pair
Glutamate receptor 1 (Homo sapiens (Human))	BDBM426253 (US10513523, Example 193 | trans-5-[7-(3-Fluoro-4-h...) Show SMILES O[C@@H]1CCN(C[C@H]1F)c1nccc2c(c(nn12)-c1ccccc1)-c1ccc2NC(=O)Cc2c1 |r| Show InChI InChI=1S/C25H22FN5O2/c26-18-14-30(11-9-21(18)32)25-27-10-8-20-23(16-6-7-19-17(12-16)13-22(33)28-19)24(29-31(20)25)15-4-2-1-3-5-15/h1-8,10,12,18,21,32H,9,11,13-14H2,(H,28,33)/t18-,21-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.320	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR
					More data for this Ligand-Target Pair
Glutamate receptor 1 (Homo sapiens (Human))	BDBM426178 (6-[2-(4-Fluorophenyl)-8-morpholino-imidazo[1,2-a]p...) Show SMILES Fc1ccc(cc1)-c1nc2c(nccn2c1-c1ccc2[nH]c(=O)sc2c1)N1CCOCC1 Show InChI InChI=1S/C23H18FN5O2S/c24-16-4-1-14(2-5-16)19-20(15-3-6-17-18(13-15)32-23(30)26-17)29-8-7-25-21(22(29)27-19)28-9-11-31-12-10-28/h1-8,13H,9-12H2,(H,26,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.320	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR
					More data for this Ligand-Target Pair
Glutamate receptor 1 (Homo sapiens (Human))	BDBM426174 (5-(8-(4-Acetylpiperazin-1-yl)-2-benzyl-5-bromoimid...) Show SMILES CC(=O)N1CCN(CC1)c1ncc(Br)n2c(c(Cc3ccccc3)nc12)-c1ccc2NC(=O)Cc2c1 Show InChI InChI=1S/C27H25BrN6O2/c1-17(35)32-9-11-33(12-10-32)26-27-31-22(13-18-5-3-2-4-6-18)25(34(27)23(28)16-29-26)19-7-8-21-20(14-19)15-24(36)30-21/h2-8,14,16H,9-13,15H2,1H3,(H,30,36)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.320	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR
					More data for this Ligand-Target Pair
Glutamate receptor 1 (Homo sapiens (Human))	BDBM426073 (5-[8-(4-Acetylpiperazin-1-yl)-2-(4-fluorophenyl)im...) Show SMILES CC(=O)N1CCN(CC1)c1nccn2c(c(nc12)-c1ccc(F)cc1)-c1ccc2NC(=O)Cc2c1 Show InChI InChI=1S/C26H23FN6O2/c1-16(34)31-10-12-32(13-11-31)25-26-30-23(17-2-5-20(27)6-3-17)24(33(26)9-8-28-25)18-4-7-21-19(14-18)15-22(35)29-21/h2-9,14H,10-13,15H2,1H3,(H,29,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR
					More data for this Ligand-Target Pair
Glutamate receptor 1 (Homo sapiens (Human))	BDBM426072 (5-[2-(4-Fluorophenyl)-8-morpholino-imidazo[1,2-a]p...) Show SMILES Fc1ccc(cc1)-c1nc2c(nccn2c1-c1ccc2[nH]c(=O)[nH]c2c1)N1CCOCC1 Show InChI InChI=1S/C23H19FN6O2/c24-16-4-1-14(2-5-16)19-20(15-3-6-17-18(13-15)27-23(31)26-17)30-8-7-25-21(22(30)28-19)29-9-11-32-12-10-29/h1-8,13H,9-12H2,(H2,26,27,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR
					More data for this Ligand-Target Pair
Glutamate receptor 1 (Homo sapiens (Human))	BDBM426142 (5-[8-(3-Fluoroazetidin-1-yl)-2-phenyl-imidazo[1,2-...) Show SMILES FC1CN(C1)c1nccn2c(c(nc12)-c1ccccc1)-c1ccc2NC(=O)Cc2c1 Show InChI InChI=1S/C23H18FN5O/c24-17-12-28(13-17)22-23-27-20(14-4-2-1-3-5-14)21(29(23)9-8-25-22)15-6-7-18-16(10-15)11-19(30)26-18/h1-10,17H,11-13H2,(H,26,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR
					More data for this Ligand-Target Pair
Glutamate receptor 1 (Homo sapiens (Human))	BDBM426108 (5-[8-(1,1-Dioxo-1,4-thiazinan-4-yl)-2-(4-fluorophe...) Show SMILES Fc1ccc(cc1)-c1nc2c(nccn2c1-c1ccc2NC(=O)Cc2c1)N1CCS(=O)(=O)CC1 Show InChI InChI=1S/C24H20FN5O3S/c25-18-4-1-15(2-5-18)21-22(16-3-6-19-17(13-16)14-20(31)27-19)30-8-7-26-23(24(30)28-21)29-9-11-34(32,33)12-10-29/h1-8,13H,9-12,14H2,(H,27,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR
					More data for this Ligand-Target Pair
Glutamate receptor 1 (Homo sapiens (Human))	BDBM426267 (5-(4-Bromo-7-morpholino-2-phenyl-pyrazolo[1,5-c]py...) Show SMILES Brc1cnc(N2CCOCC2)n2nc(c(-c3ccc4NC(=O)Cc4c3)c12)-c1ccccc1 Show InChI InChI=1S/C24H20BrN5O2/c25-18-14-26-24(29-8-10-32-11-9-29)30-23(18)21(22(28-30)15-4-2-1-3-5-15)16-6-7-19-17(12-16)13-20(31)27-19/h1-7,12,14H,8-11,13H2,(H,27,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR
					More data for this Ligand-Target Pair
Glutamate receptor 1 (Homo sapiens (Human))	BDBM426293 (4-[3-(1H-Indazol-5-yl)-2-phenyl-pyrazolo[1,5-c]pyr...) Show SMILES C1CN(CCO1)c1nccc2c(c(nn12)-c1ccccc1)-c1ccc2[nH]ncc2c1 Show InChI InChI=1S/C23H20N6O/c1-2-4-16(5-3-1)22-21(17-6-7-19-18(14-17)15-25-26-19)20-8-9-24-23(29(20)27-22)28-10-12-30-13-11-28/h1-9,14-15H,10-13H2,(H,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR
					More data for this Ligand-Target Pair
Glutamate receptor 1 (Homo sapiens (Human))	BDBM426138 (5-[8-[4-(2-Fluoroethyl)-1-piperidyl]-2-phenyl-imid...) Show SMILES FCCC1CCN(CC1)c1nccn2c(c(nc12)-c1ccccc1)-c1ccc2NC(=O)Cc2c1 Show InChI InChI=1S/C27H26FN5O/c28-11-8-18-9-13-32(14-10-18)26-27-31-24(19-4-2-1-3-5-19)25(33(27)15-12-29-26)20-6-7-22-21(16-20)17-23(34)30-22/h1-7,12,15-16,18H,8-11,13-14,17H2,(H,30,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR
					More data for this Ligand-Target Pair
Glutamate receptor 1 (Homo sapiens (Human))	BDBM426140 (5-[8-(6-Oxa-3-azabicyclo[3;1;1]heptan-3-yl)-2-phen...) Show SMILES O=C1Cc2cc(ccc2N1)-c1c(nc2c(nccn12)N1CC2CC(C1)O2)-c1ccccc1 |THB:14:19:22:25| Show InChI InChI=1S/C25H21N5O2/c31-21-11-17-10-16(6-7-20(17)27-21)23-22(15-4-2-1-3-5-15)28-25-24(26-8-9-30(23)25)29-13-18-12-19(14-29)32-18/h1-10,18-19H,11-14H2,(H,27,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR
					More data for this Ligand-Target Pair
Glutamate receptor 1 (Homo sapiens (Human))	BDBM426069 (5-[2-(4-Fluorophenyl)-8-morpholino-imidazo[1,2-a]p...) Show SMILES Fc1ccc(cc1)-c1nc2c(nccn2c1-c1ccc2NC(=O)Cc2c1)N1CCOCC1 Show InChI InChI=1S/C24H20FN5O2/c25-18-4-1-15(2-5-18)21-22(16-3-6-19-17(13-16)14-20(31)27-19)30-8-7-26-23(24(30)28-21)29-9-11-32-12-10-29/h1-8,13H,9-12,14H2,(H,27,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR
					More data for this Ligand-Target Pair
Glutamate receptor 1 (Homo sapiens (Human))	BDBM426162 (5-[8-(Dimethylamino)-2-(4-fluorophenyl)imidazo[1,2...) Show SMILES CN(C)c1nccn2c(c(nc12)-c1ccc(F)cc1)-c1ccc2[nH]c(=O)[nH]c2c1 Show InChI InChI=1S/C21H17FN6O/c1-27(2)19-20-26-17(12-3-6-14(22)7-4-12)18(28(20)10-9-23-19)13-5-8-15-16(11-13)25-21(29)24-15/h3-11H,1-2H3,(H2,24,25,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR
					More data for this Ligand-Target Pair
Glutamate receptor 1 (Homo sapiens (Human))	BDBM426093 (5-[2-(4-Fluorophenyl)-8-(3-oxopiperazin-1-yl)imida...) Show SMILES Fc1ccc(cc1)-c1nc2c(nccn2c1-c1ccc2NC(=O)Cc2c1)N1CCNC(=O)C1 Show InChI InChI=1S/C24H19FN6O2/c25-17-4-1-14(2-5-17)21-22(15-3-6-18-16(11-15)12-19(32)28-18)31-10-8-27-23(24(31)29-21)30-9-7-26-20(33)13-30/h1-6,8,10-11H,7,9,12-13H2,(H,26,33)(H,28,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR
					More data for this Ligand-Target Pair
Glutamate receptor 1 (Homo sapiens (Human))	BDBM426120 (5-[8-(3-Fluoroazetidin-1-yl)-2-(4-fluorophenyl)imi...) Show SMILES FC1CN(C1)c1nccn2c(c(nc12)-c1ccc(F)cc1)-c1ccc2NC(=O)Cc2c1 Show InChI InChI=1S/C23H17F2N5O/c24-16-4-1-13(2-5-16)20-21(14-3-6-18-15(9-14)10-19(31)27-18)30-8-7-26-22(23(30)28-20)29-11-17(25)12-29/h1-9,17H,10-12H2,(H,27,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR
					More data for this Ligand-Target Pair
Glutamate receptor 1 (Homo sapiens (Human))	BDBM426096 (5-[2-(3,4-Difluorophenyl)-8-morpholino-imidazo[1,2...) Show SMILES Fc1ccc(cc1F)-c1nc2c(nccn2c1-c1ccc2NC(=O)Cc2c1)N1CCOCC1 Show InChI InChI=1S/C24H19F2N5O2/c25-17-3-1-14(12-18(17)26)21-22(15-2-4-19-16(11-15)13-20(32)28-19)31-6-5-27-23(24(31)29-21)30-7-9-33-10-8-30/h1-6,11-12H,7-10,13H2,(H,28,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR
					More data for this Ligand-Target Pair
Glutamate receptor 1 (Homo sapiens (Human))	BDBM426248 (5-[7-(4-Fluoro-1-piperidyl)-2-phenyl-pyrazolo[1,5-...) Show SMILES FC1CCN(CC1)c1nccc2c(c(nn12)-c1ccccc1)-c1ccc2NC(=O)Cc2c1 Show InChI InChI=1S/C25H22FN5O/c26-19-9-12-30(13-10-19)25-27-11-8-21-23(17-6-7-20-18(14-17)15-22(32)28-20)24(29-31(21)25)16-4-2-1-3-5-16/h1-8,11,14,19H,9-10,12-13,15H2,(H,28,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10513523 (2019) BindingDB Entry DOI: 10.7270/Q2KW5JDR
					More data for this Ligand-Target Pair

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