Compile Data Set for Download or QSAR

Found 125 hits of ic50 for UniProtKB: P70605   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM392076 (US10301272, Example 7/9) Show SMILES CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCCCC2)C(=O)N[C@H]2C[C@@H](C2)C(O)=O)c2ccccc12 |r,wU:27.28,wD:29.33,(8.76,1.15,;7.67,.06,;6.19,.46,;7.28,1.55,;8.07,-1.42,;6.98,-2.51,;6.59,-4,;8.07,-3.6,;5.5,-2.11,;5.1,-.63,;3.61,-.23,;2.52,-1.32,;1.03,-.92,;.56,.55,;-.98,.55,;-1.46,-.92,;-.21,-1.82,;-.21,-3.36,;-1.55,-4.13,;-2.88,-3.36,;-4.21,-4.13,;-4.21,-5.67,;-2.88,-6.44,;-1.55,-5.67,;-2.07,1.64,;-1.67,3.12,;-3.56,1.24,;-4.65,2.33,;-6.19,2.33,;-6.19,3.87,;-4.65,3.87,;-7.28,4.96,;-6.88,6.44,;-8.76,4.56,;2.92,-2.8,;1.83,-3.89,;2.23,-5.38,;3.72,-5.78,;4.81,-4.69,;4.41,-3.2,)| Show InChI InChI=1S/C30H37N3O5S2/c1-30(2,3)33-40(37,38)25-14-13-23(21-11-7-8-12-22(21)25)26-24(15-18-9-5-4-6-10-18)32-28(39-26)27(34)31-20-16-19(17-20)29(35)36/h7-8,11-14,18-20,33H,4-6,9-10,15-17H2,1-3H3,(H,31,34)(H,35,36)/t19-,20-	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.0120	n/a	n/a	n/a	n/a	n/a	n/a
Phenex Pharmaceuticals AG Curated by ChEMBL					Assay Description Displacement of [125I]apamin from rat brain SkCa channel after 60 mins by scintillation counting analysis				Bioorg Med Chem Lett 28: 1446-1455 (2018) Article DOI: 10.1016/j.bmcl.2018.03.093 BindingDB Entry DOI: 10.7270/Q27W6FPC
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50155248 (CHEMBL3774478) Show SMILES [H][C@@]12CCCN1C(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@@]1([H])CSSC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@]([H])(CSSC[C@@H](N)C(=O)N[C@@H](CC(N)=O)C(=O)N1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@@]([H])(NC(=O)[C@H](CCC(O)=O)NC2=O)[C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O |r| Show InChI InChI=1S/C79H131N31O24S4/c1-35(2)26-49-70(127)107-51-31-136-135-30-41(81)63(120)105-50(28-57(84)114)71(128)108-53(73(130)99-42(12-7-8-22-80)64(121)96-38(5)77(134)110-25-11-15-54(110)75(132)102-47(18-21-58(115)116)69(126)109-59(39(6)111)76(133)95-37(4)62(119)104-49)33-138-137-32-52(106-66(123)44(14-10-24-92-79(88)89)98-65(122)43(13-9-23-91-78(86)87)97-61(118)36(3)94-72(51)129)74(131)101-45(16-19-55(82)112)67(124)100-46(17-20-56(83)113)68(125)103-48(60(85)117)27-40-29-90-34-93-40/h29,34-39,41-54,59,111H,7-28,30-33,80-81H2,1-6H3,(H2,82,112)(H2,83,113)(H2,84,114)(H2,85,117)(H,90,93)(H,94,129)(H,95,133)(H,96,121)(H,97,118)(H,98,122)(H,99,130)(H,100,124)(H,101,131)(H,102,132)(H,103,125)(H,104,119)(H,105,120)(H,106,123)(H,107,127)(H,108,128)(H,109,126)(H,115,116)(H4,86,87,91)(H4,88,89,92)/t36-,37-,38-,39+,41+,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54-,59-/m0/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.0160	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Medical College Curated by ChEMBL					Assay Description Displacement of [125I]apamin from rat cerebral cortex small conductance calcium-activated potassium channel				Bioorg Med Chem 24: 1793-810 (2016) Article DOI: 10.1016/j.bmc.2016.03.006 BindingDB Entry DOI: 10.7270/Q2J67JS7
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50092131 (1,7-diazonia-15,21-diazapentacyclo[20.6.2.27,14.08...) Show SMILES C1CCN[c+]2ccn(CCCCCn3cc[c+](NCC1)c1ccccc31)c1ccccc21 Show InChI InChI=1S/C28H34N4/c1-7-17-29-25-15-21-31(27-13-5-3-11-23(25)27)19-9-2-10-20-32-22-16-26(30-18-8-1)24-12-4-6-14-28(24)32/h3-6,11-16,21-22,29-30H,1-2,7-10,17-20H2/q+2	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Aristotelian University of Thessaloniki Curated by ChEMBL					Assay Description Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activity				Bioorg Med Chem Lett 14: 4231-5 (2004) Article DOI: 10.1016/j.bmcl.2004.06.011 BindingDB Entry DOI: 10.7270/Q2FF3W4T
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50061977 (17,25-diazonia-2,9-diazaheptacyclo[23.6.2.24,7.210...) Show SMILES C1N[c+]2ccn(Cc3cccc(Cn4cc[c+](NCc5ccc1cc5)c1ccccc41)c3)c1ccccc21 Show InChI InChI=1S/C34H30N4/c1-3-10-33-29(8-1)31-16-18-37(33)23-27-6-5-7-28(20-27)24-38-19-17-32(30-9-2-4-11-34(30)38)36-22-26-14-12-25(13-15-26)21-35-31/h1-20,35-36H,21-24H2/q+2	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...				J Med Chem 43: 420-31 (2000) Article DOI: 10.1021/jm9902537 BindingDB Entry DOI: 10.7270/Q21V5HQ2
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50061977 (17,25-diazonia-2,9-diazaheptacyclo[23.6.2.24,7.210...) Show SMILES C1N[c+]2ccn(Cc3cccc(Cn4cc[c+](NCc5ccc1cc5)c1ccccc41)c3)c1ccccc21 Show InChI InChI=1S/C34H30N4/c1-3-10-33-29(8-1)31-16-18-37(33)23-27-6-5-7-28(20-27)24-38-19-17-32(30-9-2-4-11-34(30)38)36-22-26-14-12-25(13-15-26)21-35-31/h1-20,35-36H,21-24H2/q+2	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Aristotelian University of Thessaloniki Curated by ChEMBL					Assay Description Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activity				Bioorg Med Chem Lett 14: 4231-5 (2004) Article DOI: 10.1016/j.bmcl.2004.06.011 BindingDB Entry DOI: 10.7270/Q2FF3W4T
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50474856 (CHEMBL184300) Show SMILES C1CC[n+]2ccc(NCCCCNc3cc[n+](CC1)c1ccccc31)c1ccccc21 Show InChI InChI=1S/C27H30N4/c1-8-18-30-20-14-24(22-10-2-4-12-26(22)30)28-16-6-7-17-29-25-15-21-31(19-9-1)27-13-5-3-11-23(25)27/h2-5,10-15,20-21H,1,6-9,16-19H2/p+2/b28-24+,29-25+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Aristotelian University of Thessaloniki Curated by ChEMBL					Assay Description Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activity				Bioorg Med Chem Lett 14: 4231-5 (2004) Article DOI: 10.1016/j.bmcl.2004.06.011 BindingDB Entry DOI: 10.7270/Q2FF3W4T
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50474870 (CHEMBL185146) Show SMILES C1CCNc2cc[n+](Cc3cccc(C[n+]4ccc(NC1)c1ccccc41)c3)c1ccccc21 Show InChI InChI=1S/C30H28N4/c1-3-12-29-25(10-1)27-14-18-33(29)21-23-8-7-9-24(20-23)22-34-19-15-28(32-17-6-5-16-31-27)26-11-2-4-13-30(26)34/h1-4,7-15,18-20H,5-6,16-17,21-22H2/p+2/b31-27+,32-28?	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Aristotelian University of Thessaloniki Curated by ChEMBL					Assay Description Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activity				Bioorg Med Chem Lett 14: 4231-5 (2004) Article DOI: 10.1016/j.bmcl.2004.06.011 BindingDB Entry DOI: 10.7270/Q2FF3W4T
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50474869 (CHEMBL181911) Show SMILES C1CCCNc2cc[n+](CCCCC[n+]3ccc(NCC1)c1ccccc31)c1ccccc21 Show InChI InChI=1S/C29H34N4/c1-2-9-19-31-27-17-23-33(29-15-7-5-13-25(27)29)21-11-3-10-20-32-22-16-26(30-18-8-1)24-12-4-6-14-28(24)32/h4-7,12-17,22-23H,1-3,8-11,18-21H2/p+2/b30-26+,31-27?	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Aristotelian University of Thessaloniki Curated by ChEMBL					Assay Description Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activity				Bioorg Med Chem Lett 14: 4231-5 (2004) Article DOI: 10.1016/j.bmcl.2004.06.011 BindingDB Entry DOI: 10.7270/Q2FF3W4T
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50474865 (CHEMBL183644) Show SMILES C1CCNc2cc[n+](CCCC[n+]3ccc(NCC1)c1ccccc31)c1ccccc21 Show InChI InChI=1S/C27H30N4/c1-6-16-28-24-14-20-30(26-12-4-2-10-22(24)26)18-8-9-19-31-21-15-25(29-17-7-1)23-11-3-5-13-27(23)31/h2-5,10-15,20-21H,1,6-9,16-19H2/p+2/b28-24+,29-25+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Aristotelian University of Thessaloniki Curated by ChEMBL					Assay Description Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activity				Bioorg Med Chem Lett 14: 4231-5 (2004) Article DOI: 10.1016/j.bmcl.2004.06.011 BindingDB Entry DOI: 10.7270/Q2FF3W4T
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50474867 (CHEMBL184858) Show SMILES C1CCC[n+]2ccc(NCCCCCNc3cc[n+](CC1)c1ccccc31)c1ccccc21 Show InChI InChI=1S/C29H34N4/c1-2-11-21-33-23-17-27(25-13-5-7-15-29(25)33)31-19-9-3-8-18-30-26-16-22-32(20-10-1)28-14-6-4-12-24(26)28/h4-7,12-17,22-23H,1-3,8-11,18-21H2/p+2/b30-26+,31-27+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Aristotelian University of Thessaloniki Curated by ChEMBL					Assay Description Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activity				Bioorg Med Chem Lett 14: 4231-5 (2004) Article DOI: 10.1016/j.bmcl.2004.06.011 BindingDB Entry DOI: 10.7270/Q2FF3W4T
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50473100 (CHEMBL344807) Show SMILES COc1c2C[n+]3ccc(NCc4ccc(CNc5cc[n+](Cc1ccc2)c1ccccc51)cc4)c1ccccc31 Show InChI InChI=1S/C35H30N4O/c1-40-35-27-7-6-8-28(35)24-39-20-18-32(30-10-3-5-12-34(30)39)37-22-26-15-13-25(14-16-26)21-36-31-17-19-38(23-27)33-11-4-2-9-29(31)33/h2-20H,21-24H2,1H3/p+2	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...				J Med Chem 43: 420-31 (2000) Article DOI: 10.1021/jm9902537 BindingDB Entry DOI: 10.7270/Q21V5HQ2
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50474866 (CHEMBL181912) Show SMILES C1CNc2cc[n+](Cc3cccc(C[n+]4ccc(NC1)c1ccccc41)c3)c1ccccc21 Show InChI InChI=1S/C29H26N4/c1-3-11-28-24(9-1)26-13-17-32(28)20-22-7-5-8-23(19-22)21-33-18-14-27(31-16-6-15-30-26)25-10-2-4-12-29(25)33/h1-5,7-14,17-19H,6,15-16,20-21H2/p+2/b30-26+,31-27+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Aristotelian University of Thessaloniki Curated by ChEMBL					Assay Description Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activity				Bioorg Med Chem Lett 14: 4231-5 (2004) Article DOI: 10.1016/j.bmcl.2004.06.011 BindingDB Entry DOI: 10.7270/Q2FF3W4T
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50473103 (CHEMBL430146) Show SMILES C1Nc2cc[n+](Cc3ccc(C[n+]4ccc(NCc5ccc1cc5)c1ccccc41)cc3)c1ccccc21 Show InChI InChI=1S/C34H28N4/c1-3-7-33-29(5-1)31-17-19-37(33)23-27-13-15-28(16-14-27)24-38-20-18-32(30-6-2-4-8-34(30)38)36-22-26-11-9-25(10-12-26)21-35-31/h1-20H,21-24H2/p+2	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
Aristotelian University of Thessaloniki Curated by ChEMBL					Assay Description Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activity				Bioorg Med Chem Lett 14: 4231-5 (2004) Article DOI: 10.1016/j.bmcl.2004.06.011 BindingDB Entry DOI: 10.7270/Q2FF3W4T
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50473103 (CHEMBL430146) Show SMILES C1Nc2cc[n+](Cc3ccc(C[n+]4ccc(NCc5ccc1cc5)c1ccccc41)cc3)c1ccccc21 Show InChI InChI=1S/C34H28N4/c1-3-7-33-29(5-1)31-17-19-37(33)23-27-13-15-28(16-14-27)24-38-20-18-32(30-6-2-4-8-34(30)38)36-22-26-11-9-25(10-12-26)21-35-31/h1-20H,21-24H2/p+2	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...				J Med Chem 43: 420-31 (2000) Article DOI: 10.1021/jm9902537 BindingDB Entry DOI: 10.7270/Q21V5HQ2
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50474868 (CHEMBL184891) Show SMILES C1CC[n+]2ccc(NCCCNc3cc[n+](CC1)c1ccccc31)c1ccccc21 Show InChI InChI=1S/C26H28N4/c1-6-17-29-19-13-23(21-9-2-4-11-25(21)29)27-15-8-16-28-24-14-20-30(18-7-1)26-12-5-3-10-22(24)26/h2-5,9-14,19-20H,1,6-8,15-18H2/p+2/b27-23+,28-24+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Aristotelian University of Thessaloniki Curated by ChEMBL					Assay Description Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activity				Bioorg Med Chem Lett 14: 4231-5 (2004) Article DOI: 10.1016/j.bmcl.2004.06.011 BindingDB Entry DOI: 10.7270/Q2FF3W4T
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50474871 (CHEMBL182716) Show SMILES C1CCNc2cc[n+](Cc3cccc(C[n+]4ccc(NCC1)c1ccccc41)c3)c1ccccc21 Show InChI InChI=1S/C31H30N4/c1-6-17-32-28-15-19-34(30-13-4-2-11-26(28)30)22-24-9-8-10-25(21-24)23-35-20-16-29(33-18-7-1)27-12-3-5-14-31(27)35/h2-5,8-16,19-21H,1,6-7,17-18,22-23H2/p+2/b32-28+,33-29+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
Aristotelian University of Thessaloniki Curated by ChEMBL					Assay Description Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activity				Bioorg Med Chem Lett 14: 4231-5 (2004) Article DOI: 10.1016/j.bmcl.2004.06.011 BindingDB Entry DOI: 10.7270/Q2FF3W4T
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50474863 (CHEMBL360624) Show SMILES C1CCCNc2cc[n+](Cc3cccc(C[n+]4ccc(NCC1)c1ccccc41)c3)c1ccccc21 Show InChI InChI=1S/C32H32N4/c1-2-8-19-34-30-17-21-36(32-15-6-4-13-28(30)32)24-26-11-9-10-25(22-26)23-35-20-16-29(33-18-7-1)27-12-3-5-14-31(27)35/h3-6,9-17,20-22H,1-2,7-8,18-19,23-24H2/p+2/b33-29+,34-30?	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
Aristotelian University of Thessaloniki Curated by ChEMBL					Assay Description Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activity				Bioorg Med Chem Lett 14: 4231-5 (2004) Article DOI: 10.1016/j.bmcl.2004.06.011 BindingDB Entry DOI: 10.7270/Q2FF3W4T
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50474872 (CHEMBL1180184) Show SMILES C1CCNc2cc[n+](CCCC[n+]3ccc(NC1)c1ccccc31)c1ccccc21 Show InChI InChI=1S/C26H28N4/c1-3-11-25-21(9-1)23-13-19-29(25)17-7-8-18-30-20-14-24(28-16-6-5-15-27-23)22-10-2-4-12-26(22)30/h1-4,9-14,19-20H,5-8,15-18H2/p+2/b27-23-,28-24+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Aristotelian University of Thessaloniki Curated by ChEMBL					Assay Description Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activity				Bioorg Med Chem Lett 14: 4231-5 (2004) Article DOI: 10.1016/j.bmcl.2004.06.011 BindingDB Entry DOI: 10.7270/Q2FF3W4T
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50473097 (CHEMBL136488) Show SMILES Oc1c2C[n+]3ccc(NCc4ccc(CNc5cc[n+](Cc1ccc2)c1ccccc51)cc4)c1ccccc31 Show InChI InChI=1S/C34H28N4O/c39-34-26-6-5-7-27(34)23-38-19-17-31(29-9-2-4-11-33(29)38)36-21-25-14-12-24(13-15-25)20-35-30-16-18-37(22-26)32-10-3-1-8-28(30)32/h1-19,39H,20-23H2/p+2	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...				J Med Chem 43: 420-31 (2000) Article DOI: 10.1021/jm9902537 BindingDB Entry DOI: 10.7270/Q21V5HQ2
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50474858 (CHEMBL186139) Show SMILES C1CCCNc2cc[n+](CCCCCC[n+]3ccc(NCC1)c1ccccc31)c1ccccc21 Show InChI InChI=1S/C30H36N4/c1-2-10-20-32-28-18-24-34(30-16-8-6-14-26(28)30)22-12-4-3-11-21-33-23-17-27(31-19-9-1)25-13-5-7-15-29(25)33/h5-8,13-18,23-24H,1-4,9-12,19-22H2/p+2/b31-27+,32-28?	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
Aristotelian University of Thessaloniki Curated by ChEMBL					Assay Description Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activity				Bioorg Med Chem Lett 14: 4231-5 (2004) Article DOI: 10.1016/j.bmcl.2004.06.011 BindingDB Entry DOI: 10.7270/Q2FF3W4T
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50150389 (17,23-diazonia-2,9-diazahexacyclo[21.6.2.24,7.210,...) Show SMILES C1CCn2cc[c+](NCc3ccc(CN[c+]4ccn(CC1)c1ccccc41)cc3)c1ccccc21 Show InChI InChI=1S/C31H32N4/c1-6-18-34-20-16-28(26-8-2-4-10-30(26)34)32-22-24-12-14-25(15-13-24)23-33-29-17-21-35(19-7-1)31-11-5-3-9-27(29)31/h2-5,8-17,20-21,32-33H,1,6-7,18-19,22-23H2/q+2	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
Aristotelian University of Thessaloniki Curated by ChEMBL					Assay Description Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activity				Bioorg Med Chem Lett 14: 4231-5 (2004) Article DOI: 10.1016/j.bmcl.2004.06.011 BindingDB Entry DOI: 10.7270/Q2FF3W4T
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50474859 (CHEMBL185258) Show SMILES C1CCC[n+]2ccc(NCc3ccc(CNc4cc[n+](CC1)c1ccccc41)cc3)c1ccccc21 Show InChI InChI=1S/C32H32N4/c1-2-8-20-36-22-18-30(28-10-4-6-12-32(28)36)34-24-26-15-13-25(14-16-26)23-33-29-17-21-35(19-7-1)31-11-5-3-9-27(29)31/h3-6,9-18,21-22H,1-2,7-8,19-20,23-24H2/p+2/b33-29+,34-30+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	65	n/a	n/a	n/a	n/a	n/a	n/a
Aristotelian University of Thessaloniki Curated by ChEMBL					Assay Description Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activity				Bioorg Med Chem Lett 14: 4231-5 (2004) Article DOI: 10.1016/j.bmcl.2004.06.011 BindingDB Entry DOI: 10.7270/Q2FF3W4T
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50473106 (CHEMBL137175) Show SMILES C1Nc2cc[n+](Cc3ccc(C[n+]4ccc(NCc5cccc1c5)c1ccccc41)cc3)c1ccccc21 Show InChI InChI=1S/C34H28N4/c1-3-10-33-29(8-1)31-16-18-37(33)23-25-12-14-26(15-13-25)24-38-19-17-32(30-9-2-4-11-34(30)38)36-22-28-7-5-6-27(20-28)21-35-31/h1-20H,21-24H2/p+2/b35-31+,36-32?	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
Aristotelian University of Thessaloniki Curated by ChEMBL					Assay Description Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activity				Bioorg Med Chem Lett 14: 4231-5 (2004) Article DOI: 10.1016/j.bmcl.2004.06.011 BindingDB Entry DOI: 10.7270/Q2FF3W4T
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50473106 (CHEMBL137175) Show SMILES C1Nc2cc[n+](Cc3ccc(C[n+]4ccc(NCc5cccc1c5)c1ccccc41)cc3)c1ccccc21 Show InChI InChI=1S/C34H28N4/c1-3-10-33-29(8-1)31-16-18-37(33)23-25-12-14-26(15-13-25)24-38-19-17-32(30-9-2-4-11-34(30)38)36-22-28-7-5-6-27(20-28)21-35-31/h1-20H,21-24H2/p+2/b35-31+,36-32?	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...				J Med Chem 43: 420-31 (2000) Article DOI: 10.1021/jm9902537 BindingDB Entry DOI: 10.7270/Q21V5HQ2
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50084848 (BIs-cyclo(4N-pentyl-1-(4-methylbenzyl)-4-quinolini...) Show SMILES C1CCCCCN[c+]2ccn(Cc3ccc(Cc4ccc(Cn5cc[c+](NCCCC1)c1ccccc51)cc4)cc3)c1ccccc21 Show InChI InChI=1S/C43H48N4/c1-2-4-6-12-28-45-41-26-30-47(43-16-10-8-14-39(41)43)33-37-23-19-35(20-24-37)31-34-17-21-36(22-18-34)32-46-29-25-40(44-27-11-5-3-1)38-13-7-9-15-42(38)46/h7-10,13-26,29-30,44-45H,1-6,11-12,27-28,31-33H2/q+2	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...				J Med Chem 43: 420-31 (2000) Article DOI: 10.1021/jm9902537 BindingDB Entry DOI: 10.7270/Q21V5HQ2
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3 (Rattus norvegicus)	BDBM50215069 (1,2,3-tris-[3-(4-(N-ethyl)-quinoliniumylamino)-pro...) Show SMILES CCn1cc\c(=[NH+]\CCCOc2cccc(OCCCNc3cc[n+](CC)c4ccccc34)c2OCCC\[NH+]=c2/ccn(CC)c3ccccc23)c2ccccc12 Show InChI InChI=1S/C48H54N6O3/c1-4-52-31-25-40(37-17-7-10-20-43(37)52)49-28-14-34-55-46-23-13-24-47(56-35-15-29-50-41-26-32-53(5-2)44-21-11-8-18-38(41)44)48(46)57-36-16-30-51-42-27-33-54(6-3)45-22-12-9-19-39(42)45/h7-13,17-27,31-33H,4-6,14-16,28-30,34-36H2,1-3H3/p+3/b49-40-,51-42+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	86	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description Inhibition of SKca channel-mediated after-hypepolarization in rat sympathetic neurons				Bioorg Med Chem 15: 5457-79 (2007) Article DOI: 10.1016/j.bmc.2007.05.054 BindingDB Entry DOI: 10.7270/Q2416WSJ
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50473094 (CHEMBL137155) Show SMILES Cc1ccc-2c(Cc3cc(C[n+]4ccc(NCCCCCCCCCCNc5cc[n+](C)c6ccccc56)c5ccccc45)ccc-23)c1 Show InChI InChI=1S/C44H48N4/c1-33-19-21-37-35(29-33)31-36-30-34(20-22-38(36)37)32-48-28-24-42(40-16-10-12-18-44(40)48)46-26-14-8-6-4-3-5-7-13-25-45-41-23-27-47(2)43-17-11-9-15-39(41)43/h9-12,15-24,27-30H,3-8,13-14,25-26,31-32H2,1-2H3/p+2	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...				J Med Chem 43: 420-31 (2000) Article DOI: 10.1021/jm9902537 BindingDB Entry DOI: 10.7270/Q21V5HQ2
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3 (Rattus norvegicus)	BDBM50215071 (CHEMBL375272 | N-[3-(4-quinolinylamino)-propyl]-N-...) Show SMILES C(CCNc1ccnc2ccccc12)CCN(CCCNc1ccnc2ccccc12)c1cc(OCCCNc2ccnc3ccccc23)cc(OCCCNc2ccnc3ccccc23)c1 Show InChI InChI=1S/C56H59N9O2/c1(10-27-57-53-23-31-61-49-19-6-2-15-45(49)53)11-35-65(36-12-28-58-54-24-32-62-50-20-7-3-16-46(50)54)42-39-43(66-37-13-29-59-55-25-33-63-51-21-8-4-17-47(51)55)41-44(40-42)67-38-14-30-60-56-26-34-64-52-22-9-5-18-48(52)56/h2-9,15-26,31-34,39-41H,1,10-14,27-30,35-38H2,(H,57,61)(H,58,62)(H,59,63)(H,60,64)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	93	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description Inhibition of SKca channel-mediated after-hypepolarization in rat sympathetic neurons				Bioorg Med Chem 15: 5457-79 (2007) Article DOI: 10.1016/j.bmc.2007.05.054 BindingDB Entry DOI: 10.7270/Q2416WSJ
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50473098 (CHEMBL342213) Show SMILES Oc1c2C[n+]3ccc(NCc4ccc(CNc5cc[n+](Cc1cc(I)c2)c1ccccc51)cc4)c1ccccc31 Show InChI InChI=1S/C34H27IN4O/c35-27-17-25-21-38-15-13-30(28-5-1-3-7-32(28)38)36-19-23-9-11-24(12-10-23)20-37-31-14-16-39(22-26(18-27)34(25)40)33-8-4-2-6-29(31)33/h1-18,40H,19-22H2/p+2	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...				J Med Chem 43: 420-31 (2000) Article DOI: 10.1021/jm9902537 BindingDB Entry DOI: 10.7270/Q21V5HQ2
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50084852 (1,14-diazonia-22,33-diazaheptacyclo[32.6.2.214,21....) Show SMILES C1CCCCCN[c+]2ccn(Cc3cccc(c3)-c3cccc(Cn4cc[c+](NCCCC1)c1ccccc41)c3)c1ccccc21 Show InChI InChI=1S/C42H46N4/c1-2-4-6-12-26-44-40-24-28-46(42-22-10-8-20-38(40)42)32-34-16-14-18-36(30-34)35-17-13-15-33(29-35)31-45-27-23-39(43-25-11-5-3-1)37-19-7-9-21-41(37)45/h7-10,13-24,27-30,43-44H,1-6,11-12,25-26,31-32H2/q+2	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...				J Med Chem 43: 420-31 (2000) Article DOI: 10.1021/jm9902537 BindingDB Entry DOI: 10.7270/Q21V5HQ2
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50473099 (CHEMBL140380) Show SMILES C1c2cc3C[n+]4ccc(NCc5ccc(cc5)-c5ccc(CNc6cc[n+](Cc7ccc(c1c7)-c2cc3)c1ccccc61)cc5)c1ccccc41 Show InChI InChI=1S/C47H36N4/c1-3-7-46-42(5-1)44-21-23-50(46)30-34-13-19-40-38(25-34)27-39-26-35(14-20-41(39)40)31-51-24-22-45(43-6-2-4-8-47(43)51)49-29-33-11-17-37(18-12-33)36-15-9-32(10-16-36)28-48-44/h1-26H,27-31H2/p+2/b48-44+,49-45+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...				J Med Chem 43: 420-31 (2000) Article DOI: 10.1021/jm9902537 BindingDB Entry DOI: 10.7270/Q21V5HQ2
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50473107 (CHEMBL341700) Show SMILES C1Nc2cc[n+](Cc3cccc(C[n+]4ccc(NCc5cccc1c5)c1ccccc41)c3)c1ccccc21 Show InChI InChI=1S/C34H28N4/c1-3-13-33-29(11-1)31-15-17-37(33)23-27-9-6-10-28(20-27)24-38-18-16-32(30-12-2-4-14-34(30)38)36-22-26-8-5-7-25(19-26)21-35-31/h1-20H,21-24H2/p+2/b35-31-,36-32?	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
Aristotelian University of Thessaloniki Curated by ChEMBL					Assay Description Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activity				Bioorg Med Chem Lett 14: 4231-5 (2004) Article DOI: 10.1016/j.bmcl.2004.06.011 BindingDB Entry DOI: 10.7270/Q2FF3W4T
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50474857 (CHEMBL185106) Show SMILES C1CC[n+]2ccc(NCCCNc3cc[n+](C1)c1ccccc31)c1ccccc21 Show InChI InChI=1S/C25H26N4/c1-3-10-24-20(8-1)22-12-18-28(24)16-5-6-17-29-19-13-23(27-15-7-14-26-22)21-9-2-4-11-25(21)29/h1-4,8-13,18-19H,5-7,14-17H2/p+2/b26-22+,27-23+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
Aristotelian University of Thessaloniki Curated by ChEMBL					Assay Description Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activity				Bioorg Med Chem Lett 14: 4231-5 (2004) Article DOI: 10.1016/j.bmcl.2004.06.011 BindingDB Entry DOI: 10.7270/Q2FF3W4T
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3 (Rattus norvegicus)	BDBM50215076 (CHEMBL229982 | N-[3-(4-quinolinylamino)-propyl]-N-...) Show SMILES C(CCNc1ccnc2ccccc12)CCN(CCCNc1ccnc2ccccc12)Cc1cc(OCCCNc2ccnc3ccccc23)cc(OCCCNc2ccnc3ccccc23)c1 Show InChI InChI=1S/C57H61N9O2/c1(10-27-58-54-23-31-62-50-19-6-2-15-46(50)54)11-35-66(36-12-28-59-55-24-32-63-51-20-7-3-16-47(51)55)42-43-39-44(67-37-13-29-60-56-25-33-64-52-21-8-4-17-48(52)56)41-45(40-43)68-38-14-30-61-57-26-34-65-53-22-9-5-18-49(53)57/h2-9,15-26,31-34,39-41H,1,10-14,27-30,35-38,42H2,(H,58,62)(H,59,63)(H,60,64)(H,61,65)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description Inhibition of SKca channel-mediated after-hypepolarization in rat sympathetic neurons				Bioorg Med Chem 15: 5457-79 (2007) Article DOI: 10.1016/j.bmc.2007.05.054 BindingDB Entry DOI: 10.7270/Q2416WSJ
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3 (Rattus norvegicus)	BDBM50215070 (1,2,3-tri[3-(4-quinolinylamino)-propoxy]-benzene |...) Show SMILES C(CNc1ccnc2ccccc12)COc1cccc(OCCCNc2ccnc3ccccc23)c1OCCCNc1ccnc2ccccc12 Show InChI InChI=1S/C42H42N6O3/c1-4-14-34-31(11-1)37(19-25-46-34)43-22-8-28-49-40-17-7-18-41(50-29-9-23-44-38-20-26-47-35-15-5-2-12-32(35)38)42(40)51-30-10-24-45-39-21-27-48-36-16-6-3-13-33(36)39/h1-7,11-21,25-27H,8-10,22-24,28-30H2,(H,43,46)(H,44,47)(H,45,48)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description Inhibition of SKca channel-mediated after-hypepolarization in rat sympathetic neurons				Bioorg Med Chem 15: 5457-79 (2007) Article DOI: 10.1016/j.bmc.2007.05.054 BindingDB Entry DOI: 10.7270/Q2416WSJ
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50473107 (CHEMBL341700) Show SMILES C1Nc2cc[n+](Cc3cccc(C[n+]4ccc(NCc5cccc1c5)c1ccccc41)c3)c1ccccc21 Show InChI InChI=1S/C34H28N4/c1-3-13-33-29(11-1)31-15-17-37(33)23-27-9-6-10-28(20-27)24-38-18-16-32(30-12-2-4-14-34(30)38)36-22-26-8-5-7-25(19-26)21-35-31/h1-20H,21-24H2/p+2/b35-31-,36-32?	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...				J Med Chem 43: 420-31 (2000) Article DOI: 10.1021/jm9902537 BindingDB Entry DOI: 10.7270/Q21V5HQ2
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50084849 (Bis-quinolinium cyclophane analogue | CHEMBL258254...) Show SMILES C1CCCCCN[c+]2ccn(Cc3ccc(cc3)\C=C/c3ccc(Cn4cc[c+](NCCCC1)c1ccccc41)cc3)c1ccccc21 |c:19| Show InChI InChI=1S/C44H48N4/c1-2-4-6-12-30-46-42-28-32-48(44-16-10-8-14-40(42)44)34-38-25-21-36(22-26-38)18-17-35-19-23-37(24-20-35)33-47-31-27-41(45-29-11-5-3-1)39-13-7-9-15-43(39)47/h7-10,13-28,31-32,45-46H,1-6,11-12,29-30,33-34H2/q+2/b18-17-	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...				J Med Chem 43: 420-31 (2000) Article DOI: 10.1021/jm9902537 BindingDB Entry DOI: 10.7270/Q21V5HQ2
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50474862 (CHEMBL425707) Show SMILES C1C[n+]2ccc(NCc3ccc(CNc4cc[n+](C1)c1ccccc41)cc3)c1ccccc21 Show InChI InChI=1S/C29H26N4/c1-3-8-28-24(6-1)26-14-18-32(28)16-5-17-33-19-15-27(25-7-2-4-9-29(25)33)31-21-23-12-10-22(11-13-23)20-30-26/h1-4,6-15,18-19H,5,16-17,20-21H2/p+2/b30-26+,31-27+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
Aristotelian University of Thessaloniki Curated by ChEMBL					Assay Description Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activity				Bioorg Med Chem Lett 14: 4231-5 (2004) Article DOI: 10.1016/j.bmcl.2004.06.011 BindingDB Entry DOI: 10.7270/Q2FF3W4T
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50474873 (CHEMBL185137) Show SMILES C1CC[n+]2ccc(NCc3ccc(CNc4cc[n+](C1)c1ccccc41)cc3)c1ccccc21 Show InChI InChI=1S/C30H28N4/c1-3-9-29-25(7-1)27-15-19-33(29)17-5-6-18-34-20-16-28(26-8-2-4-10-30(26)34)32-22-24-13-11-23(12-14-24)21-31-27/h1-4,7-16,19-20H,5-6,17-18,21-22H2/p+2/b31-27+,32-28+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
Aristotelian University of Thessaloniki Curated by ChEMBL					Assay Description Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activity				Bioorg Med Chem Lett 14: 4231-5 (2004) Article DOI: 10.1016/j.bmcl.2004.06.011 BindingDB Entry DOI: 10.7270/Q2FF3W4T
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50473102 (CHEMBL137266) Show SMILES C1Nc2cc[n+](Cc3ccc(cc3)-c3ccc(C[n+]4ccc(NCc5ccc(Cc6ccc1cc6)cc5)c1ccccc41)cc3)c1ccccc21 Show InChI InChI=1S/C47H38N4/c1-3-7-46-42(5-1)44-25-27-50(46)32-38-17-21-40(22-18-38)41-23-19-39(20-24-41)33-51-28-26-45(43-6-2-4-8-47(43)51)49-31-37-15-11-35(12-16-37)29-34-9-13-36(14-10-34)30-48-44/h1-28H,29-33H2/p+2	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...				J Med Chem 43: 420-31 (2000) Article DOI: 10.1021/jm9902537 BindingDB Entry DOI: 10.7270/Q21V5HQ2
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50084839 (Bis-quinolinium cyclophane analogue | CHEMBL6266 |...) Show SMILES C1CCCCCN[c+]2ccn(Cc3ccc(cc3)-c3ccc(Cn4cc[c+](NCCCC1)c1ccccc41)cc3)c1ccccc21 Show InChI InChI=1S/C42H46N4/c1-2-4-6-12-28-44-40-26-30-46(42-16-10-8-14-38(40)42)32-34-19-23-36(24-20-34)35-21-17-33(18-22-35)31-45-29-25-39(43-27-11-5-3-1)37-13-7-9-15-41(37)45/h7-10,13-26,29-30,43-44H,1-6,11-12,27-28,31-32H2/q+2	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...				J Med Chem 43: 420-31 (2000) Article DOI: 10.1021/jm9902537 BindingDB Entry DOI: 10.7270/Q21V5HQ2
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50084851 (Bis-quinolinium cyclophane analogue | CHEMBL266885...) Show SMILES C1CCCCCN[c+]2ccn(Cc3ccc(CCc4ccc(Cn5cc[c+](NCCCC1)c1ccccc51)cc4)cc3)c1ccccc21 Show InChI InChI=1S/C44H50N4/c1-2-4-6-12-30-46-42-28-32-48(44-16-10-8-14-40(42)44)34-38-25-21-36(22-26-38)18-17-35-19-23-37(24-20-35)33-47-31-27-41(45-29-11-5-3-1)39-13-7-9-15-43(39)47/h7-10,13-16,19-28,31-32,45-46H,1-6,11-12,17-18,29-30,33-34H2/q+2	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...				J Med Chem 43: 420-31 (2000) Article DOI: 10.1021/jm9902537 BindingDB Entry DOI: 10.7270/Q21V5HQ2
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50054105 ((Z)-1.1'-[stilbene-4,4'-diylbis(methylene)]bis(4-a...) Show SMILES [NH2+]=c1ccn(Cc2ccc(\C=C/c3ccc(Cn4ccc(=[NH2+])c5ccccc45)cc3)cc2)c2ccccc12 Show InChI InChI=1S/C34H28N4/c35-31-19-21-37(33-7-3-1-5-29(31)33)23-27-15-11-25(12-16-27)9-10-26-13-17-28(18-14-26)24-38-22-20-32(36)30-6-2-4-8-34(30)38/h1-22,35-36H,23-24H2/p+2/b10-9-,35-31?,36-32?	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...				J Med Chem 43: 420-31 (2000) Article DOI: 10.1021/jm9902537 BindingDB Entry DOI: 10.7270/Q21V5HQ2
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50474864 (CHEMBL119859) Show SMILES [I-].[I-].C1CCCCNc2cc[n+](CCCCCCCC[n+]3ccc(NCCC1)c1ccccc31)c1ccccc21 Show InChI InChI=1S/C34H44N4/c1-2-6-14-24-36-32-22-28-38(34-20-12-10-18-30(32)34)26-16-8-4-3-7-15-25-37-27-21-31(35-23-13-5-1)29-17-9-11-19-33(29)37/h9-12,17-22,27-28H,1-8,13-16,23-26H2/p+2/b35-31+,36-32?	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
Aristotelian University of Thessaloniki Curated by ChEMBL					Assay Description Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activity				Bioorg Med Chem Lett 14: 4231-5 (2004) Article DOI: 10.1016/j.bmcl.2004.06.011 BindingDB Entry DOI: 10.7270/Q2FF3W4T
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50473108 (CHEMBL137116) Show SMILES C1CCCCC[n+]2ccc(NCc3ccc(cc3)-c3ccc(CNc4cc[n+](CCCC1)c1ccccc41)cc3)c1ccccc21 Show InChI InChI=1S/C42H44N4/c1-2-4-6-12-28-46-30-26-40(38-14-8-10-16-42(38)46)44-32-34-19-23-36(24-20-34)35-21-17-33(18-22-35)31-43-39-25-29-45(27-11-5-3-1)41-15-9-7-13-37(39)41/h7-10,13-26,29-30H,1-6,11-12,27-28,31-32H2/p+2/b43-39+,44-40+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...				J Med Chem 43: 420-31 (2000) Article DOI: 10.1021/jm9902537 BindingDB Entry DOI: 10.7270/Q21V5HQ2
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3 (Rattus norvegicus)	BDBM50215075 (CHEMBL229818 | N-[3-(4-quinolinylamino)-propyl]-3,...) Show SMILES C(CNc1cc(OCCCNc2ccnc3ccccc23)cc(OCCCNc2ccnc3ccccc23)c1)CNc1ccnc2ccccc12 Show InChI InChI=1S/C42H43N7O2/c1-4-13-37-34(10-1)40(16-23-47-37)44-20-7-19-43-31-28-32(50-26-8-21-45-41-17-24-48-38-14-5-2-11-35(38)41)30-33(29-31)51-27-9-22-46-42-18-25-49-39-15-6-3-12-36(39)42/h1-6,10-18,23-25,28-30,43H,7-9,19-22,26-27H2,(H,44,47)(H,45,48)(H,46,49)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	220	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description Inhibition of SKca channel-mediated after-hypepolarization in rat sympathetic neurons				Bioorg Med Chem 15: 5457-79 (2007) Article DOI: 10.1016/j.bmc.2007.05.054 BindingDB Entry DOI: 10.7270/Q2416WSJ
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50473111 (CHEMBL137256) Show SMILES C1Nc2cc[n+](Cc3ccc(cc3)\C=C/c3ccc(C[n+]4ccc(NCc5ccc(Cc6ccc1cc6)cc5)c1ccccc41)cc3)c1ccccc21 |c:14| Show InChI InChI=1S/C49H40N4/c1-3-7-48-44(5-1)46-27-29-52(48)34-42-23-11-36(12-24-42)9-10-37-13-25-43(26-14-37)35-53-30-28-47(45-6-2-4-8-49(45)53)51-33-41-21-17-39(18-22-41)31-38-15-19-40(20-16-38)32-50-46/h1-30H,31-35H2/p+2/b10-9-,50-46+,51-47?	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...				J Med Chem 43: 420-31 (2000) Article DOI: 10.1021/jm9902537 BindingDB Entry DOI: 10.7270/Q21V5HQ2
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50474861 (CHEMBL185230) Show SMILES C1CCCCCNc2cc[n+](CCCCCCCCCC[n+]3ccc(NCCCC1)c1ccccc31)c1ccccc21 Show InChI InChI=1S/C38H52N4/c1-2-6-10-18-28-40-36-26-32-42(38-24-16-14-22-34(36)38)30-20-12-8-4-3-7-11-19-29-41-31-25-35(39-27-17-9-5-1)33-21-13-15-23-37(33)41/h13-16,21-26,31-32H,1-12,17-20,27-30H2/p+2/b39-35+,40-36?	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a	n/a
Aristotelian University of Thessaloniki Curated by ChEMBL					Assay Description Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activity				Bioorg Med Chem Lett 14: 4231-5 (2004) Article DOI: 10.1016/j.bmcl.2004.06.011 BindingDB Entry DOI: 10.7270/Q2FF3W4T
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1/2/3 (Rattus norvegicus-RAT-Rattus norvegicus (Rat))	BDBM50473109 (CHEMBL136303) Show SMILES C1Nc2cc[n+](Cc3ccc(Cc4ccc(C[n+]5ccc(NCc6ccc(Cc7ccc1cc7)cc6)c1ccccc51)cc4)cc3)c1ccccc21 Show InChI InChI=1S/C48H40N4/c1-3-7-47-43(5-1)45-25-27-51(47)33-41-21-13-37(14-22-41)30-38-15-23-42(24-16-38)34-52-28-26-46(44-6-2-4-8-48(44)52)50-32-40-19-11-36(12-20-40)29-35-9-17-39(18-10-35)31-49-45/h1-28H,29-34H2/p+2/b49-45+,50-46+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...				J Med Chem 43: 420-31 (2000) Article DOI: 10.1021/jm9902537 BindingDB Entry DOI: 10.7270/Q21V5HQ2
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3 (Rattus norvegicus)	BDBM50215072 (CHEMBL389273 | N-(4-quinolinyl)-3,4-di-[3-(4-quino...) Show SMILES C(CNc1ccnc2ccccc12)COc1ccc(CCNc2ccnc3ccccc23)cc1OCCCNc1ccnc2ccccc12 Show InChI InChI=1S/C41H40N6O2/c1-4-12-34-31(9-1)37(18-24-45-34)42-21-7-27-48-40-16-15-30(17-23-44-39-20-26-47-36-14-6-3-11-33(36)39)29-41(40)49-28-8-22-43-38-19-25-46-35-13-5-2-10-32(35)38/h1-6,9-16,18-20,24-26,29H,7-8,17,21-23,27-28H2,(H,42,45)(H,43,46)(H,44,47)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	270	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description Inhibition of SKca channel-mediated after-hypepolarization in rat sympathetic neurons				Bioorg Med Chem 15: 5457-79 (2007) Article DOI: 10.1016/j.bmc.2007.05.054 BindingDB Entry DOI: 10.7270/Q2416WSJ
					More data for this Ligand-Target Pair

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