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Compile Data Set for Download or QSAR

Found 81 hits of ec50 for UniProtKB: P56703   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Proto-oncogene Wnt-3


(Homo sapiens (Human))		BDBM50265554
PNG
((2S)-N-(tert-Butyl)-2-{[4-({[5-(phenylsulfonyl)-2-...)
Show SMILES CC(C)(C)NC(=O)N1CCC[C@H]1C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1 |r|
Show InChI InChI=1S/C28H35F3N4O6S2/c1-27(2,3)32-26(37)35-15-7-10-23(35)25(36)34-16-13-19(14-17-34)33-43(40,41)24-18-21(11-12-22(24)28(29,30)31)42(38,39)20-8-5-4-6-9-20/h4-6,8-9,11-12,18-19,23,33H,7,10,13-17H2,1-3H3,(H,32,37)/t23-/m0/s1
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay

J Med Chem 52: 105-16 (2009)


Article DOI: 10.1021/jm801144h
BindingDB Entry DOI: 10.7270/Q2NZ87HT
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-3


(Homo sapiens (Human))		BDBM50265500
PNG
((S)-tert-butyl 2-(4-(5-(phenylsulfonyl)-2-(trifluo...)
Show SMILES CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1 |r|
Show InChI InChI=1S/C28H34F3N3O7S2/c1-27(2,3)41-26(36)34-15-7-10-23(34)25(35)33-16-13-19(14-17-33)32-43(39,40)24-18-21(11-12-22(24)28(29,30)31)42(37,38)20-8-5-4-6-9-20/h4-6,8-9,11-12,18-19,23,32H,7,10,13-17H2,1-3H3/t23-/m0/s1
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay

J Med Chem 52: 105-16 (2009)


Article DOI: 10.1021/jm801144h
BindingDB Entry DOI: 10.7270/Q2NZ87HT
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-3


(Homo sapiens (Human))		BDBM50265502
PNG
(CHEMBL504979 | tert-Butyl(5S)-2-oxo-5-{[4-({[5-(Ph...)
Show SMILES CC(C)(C)OC(=O)N1[C@@H](CCC1=O)C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1 |r|
Show InChI InChI=1S/C28H32F3N3O8S2/c1-27(2,3)42-26(37)34-22(11-12-24(34)35)25(36)33-15-13-18(14-16-33)32-44(40,41)23-17-20(9-10-21(23)28(29,30)31)43(38,39)19-7-5-4-6-8-19/h4-10,17-18,22,32H,11-16H2,1-3H3/t22-/m0/s1
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay

J Med Chem 52: 105-16 (2009)


Article DOI: 10.1021/jm801144h
BindingDB Entry DOI: 10.7270/Q2NZ87HT
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-3


(Homo sapiens (Human))		BDBM50265545
PNG
(CHEMBL500903 | N-[1-(1-Isobutyryl-L-prolyl)piperid...)
Show SMILES CC(C)C(=O)N1CCC[C@H]1C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1 |r|
Show InChI InChI=1S/C27H32F3N3O6S2/c1-18(2)25(34)33-14-6-9-23(33)26(35)32-15-12-19(13-16-32)31-41(38,39)24-17-21(10-11-22(24)27(28,29)30)40(36,37)20-7-4-3-5-8-20/h3-5,7-8,10-11,17-19,23,31H,6,9,12-16H2,1-2H3/t23-/m0/s1
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay

J Med Chem 52: 105-16 (2009)


Article DOI: 10.1021/jm801144h
BindingDB Entry DOI: 10.7270/Q2NZ87HT
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-3


(Homo sapiens (Human))		BDBM50265553
PNG
((2S)-N-Ethyl-2-{[4-({[5-(phenylsulfonyl)-2-(triflu...)
Show SMILES CCNC(=O)N1CCC[C@H]1C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1 |r|
Show InChI InChI=1S/C26H31F3N4O6S2/c1-2-30-25(35)33-14-6-9-22(33)24(34)32-15-12-18(13-16-32)31-41(38,39)23-17-20(10-11-21(23)26(27,28)29)40(36,37)19-7-4-3-5-8-19/h3-5,7-8,10-11,17-18,22,31H,2,6,9,12-16H2,1H3,(H,30,35)/t22-/m0/s1
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay

J Med Chem 52: 105-16 (2009)


Article DOI: 10.1021/jm801144h
BindingDB Entry DOI: 10.7270/Q2NZ87HT
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-3


(Homo sapiens (Human))		BDBM50265547
PNG
(CHEMBL455476 | N-{1-[1-(3,3-Dimethylbutanoyl)-L-pr...)
Show SMILES CC(C)(C)CC(=O)N1CCC[C@H]1C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1 |r|
Show InChI InChI=1S/C29H36F3N3O6S2/c1-28(2,3)19-26(36)35-15-7-10-24(35)27(37)34-16-13-20(14-17-34)33-43(40,41)25-18-22(11-12-23(25)29(30,31)32)42(38,39)21-8-5-4-6-9-21/h4-6,8-9,11-12,18,20,24,33H,7,10,13-17,19H2,1-3H3/t24-/m0/s1
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay

J Med Chem 52: 105-16 (2009)


Article DOI: 10.1021/jm801144h
BindingDB Entry DOI: 10.7270/Q2NZ87HT
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-3


(Homo sapiens (Human))		BDBM50265480
PNG
(CHEMBL523726 | N-[1-(Morpholin-4-ylacetyl)piperidi...)
Show SMILES FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)CN1CCOCC1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C24H28F3N3O6S2/c25-24(26,27)21-7-6-20(37(32,33)19-4-2-1-3-5-19)16-22(21)38(34,35)28-18-8-10-30(11-9-18)23(31)17-29-12-14-36-15-13-29/h1-7,16,18,28H,8-15,17H2
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay

J Med Chem 52: 105-16 (2009)


Article DOI: 10.1021/jm801144h
BindingDB Entry DOI: 10.7270/Q2NZ87HT
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-3


(Homo sapiens (Human))		BDBM50265580
PNG
((2S)-N,N-Dimethyl-2-{[4-({[5-(phenylsulfonyl)-2-(t...)
Show SMILES CN(C)C(=O)N1CCC[C@H]1C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1 |r|
Show InChI InChI=1S/C26H31F3N4O6S2/c1-31(2)25(35)33-14-6-9-22(33)24(34)32-15-12-18(13-16-32)30-41(38,39)23-17-20(10-11-21(23)26(27,28)29)40(36,37)19-7-4-3-5-8-19/h3-5,7-8,10-11,17-18,22,30H,6,9,12-16H2,1-2H3/t22-/m0/s1
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay

J Med Chem 52: 105-16 (2009)


Article DOI: 10.1021/jm801144h
BindingDB Entry DOI: 10.7270/Q2NZ87HT
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-3


(Homo sapiens (Human))		BDBM50265479
PNG
(5-(Phenylsulfonyl)-N-[1-(pyrrolidin-1-ylacetyl)pip...)
Show SMILES FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)CN1CCCC1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C24H28F3N3O5S2/c25-24(26,27)21-9-8-20(36(32,33)19-6-2-1-3-7-19)16-22(21)37(34,35)28-18-10-14-30(15-11-18)23(31)17-29-12-4-5-13-29/h1-3,6-9,16,18,28H,4-5,10-15,17H2
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay

J Med Chem 52: 105-16 (2009)


Article DOI: 10.1021/jm801144h
BindingDB Entry DOI: 10.7270/Q2NZ87HT
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-3


(Homo sapiens (Human))		BDBM50294836
PNG
(4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*...)
Show SMILES Oc1c2[C@H]3CC[C@H](C3)c2c(O)n1-c1ccc(cc1)C(=O)Nc1cccc2cccnc12 |r|
Show InChI InChI=1S/C25H21N3O3/c29-23(27-19-5-1-3-14-4-2-12-26-22(14)19)15-8-10-18(11-9-15)28-24(30)20-16-6-7-17(13-16)21(20)25(28)31/h1-5,8-12,16-17,30-31H,6-7,13H2,(H,27,29)/t16-,17+
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The University of Texas Southwestern Medical Center at Dallas

Curated by ChEMBL


Assay Description
Inhibition of Wnt3 expressed in mouse L-cells assessed as inhibition of Wnt/catanin signaling pathway by luciferase reporter gene assay

Bioorg Med Chem Lett 19: 3825-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.040
BindingDB Entry DOI: 10.7270/Q2DZ08BS
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-3


(Homo sapiens (Human))		BDBM50265501
PNG
((R)-tert-butyl 2-(4-(5-(phenylsulfonyl)-2-(trifluo...)
Show SMILES CC(C)(C)OC(=O)N1CCC[C@@H]1C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1 |r|
Show InChI InChI=1S/C28H34F3N3O7S2/c1-27(2,3)41-26(36)34-15-7-10-23(34)25(35)33-16-13-19(14-17-33)32-43(39,40)24-18-21(11-12-22(24)28(29,30)31)42(37,38)20-8-5-4-6-9-20/h4-6,8-9,11-12,18-19,23,32H,7,10,13-17H2,1-3H3/t23-/m1/s1
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay

J Med Chem 52: 105-16 (2009)


Article DOI: 10.1021/jm801144h
BindingDB Entry DOI: 10.7270/Q2NZ87HT
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-3


(Homo sapiens (Human))		BDBM50265499
PNG
(CHEMBL495534 | N-[1-(1H-Imidazol-1-ylacetyl)piperi...)
Show SMILES FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)Cn1ccnc1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C23H23F3N4O5S2/c24-23(25,26)20-7-6-19(36(32,33)18-4-2-1-3-5-18)14-21(20)37(34,35)28-17-8-11-30(12-9-17)22(31)15-29-13-10-27-16-29/h1-7,10,13-14,16-17,28H,8-9,11-12,15H2
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay

J Med Chem 52: 105-16 (2009)


Article DOI: 10.1021/jm801144h
BindingDB Entry DOI: 10.7270/Q2NZ87HT
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-3


(Homo sapiens (Human))		BDBM50265582
PNG
(CHEMBL496581 | N-[1-(1-Methyl-L-prolyl)piperidin-4...)
Show SMILES CN1CCC[C@H]1C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1 |r|
Show InChI InChI=1S/C24H28F3N3O5S2/c1-29-13-5-8-21(29)23(31)30-14-11-17(12-15-30)28-37(34,35)22-16-19(9-10-20(22)24(25,26)27)36(32,33)18-6-3-2-4-7-18/h2-4,6-7,9-10,16-17,21,28H,5,8,11-15H2,1H3/t21-/m0/s1
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay

J Med Chem 52: 105-16 (2009)


Article DOI: 10.1021/jm801144h
BindingDB Entry DOI: 10.7270/Q2NZ87HT
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-3


(Homo sapiens (Human))		BDBM50265505
PNG
(CHEMBL525899 | N-[1-(5-oxo-L-Prolyl)piperidin-4-yl...)
Show SMILES FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)[C@@H]1CCC(=O)N1)S(=O)(=O)c1ccccc1 |r|
Show InChI InChI=1S/C23H24F3N3O6S2/c24-23(25,26)18-7-6-17(36(32,33)16-4-2-1-3-5-16)14-20(18)37(34,35)28-15-10-12-29(13-11-15)22(31)19-8-9-21(30)27-19/h1-7,14-15,19,28H,8-13H2,(H,27,30)/t19-/m0/s1
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay

J Med Chem 52: 105-16 (2009)


Article DOI: 10.1021/jm801144h
BindingDB Entry DOI: 10.7270/Q2NZ87HT
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-3


(Homo sapiens (Human))		BDBM50265481
PNG
(5-(Phenylsulfonyl)-N-[1-(piperazin-1-ylacetyl)pipe...)
Show SMILES FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)CN1CCNCC1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C24H29F3N4O5S2/c25-24(26,27)21-7-6-20(37(33,34)19-4-2-1-3-5-19)16-22(21)38(35,36)29-18-8-12-31(13-9-18)23(32)17-30-14-10-28-11-15-30/h1-7,16,18,28-29H,8-15,17H2
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay

J Med Chem 52: 105-16 (2009)


Article DOI: 10.1021/jm801144h
BindingDB Entry DOI: 10.7270/Q2NZ87HT
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-3


(Homo sapiens (Human))		BDBM50265544
PNG
(CHEMBL525970 | N-[1-(1-Acetyl-L-prolyl)piperidin-4...)
Show SMILES CC(=O)N1CCC[C@H]1C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1 |r|
Show InChI InChI=1S/C25H28F3N3O6S2/c1-17(32)31-13-5-8-22(31)24(33)30-14-11-18(12-15-30)29-39(36,37)23-16-20(9-10-21(23)25(26,27)28)38(34,35)19-6-3-2-4-7-19/h2-4,6-7,9-10,16,18,22,29H,5,8,11-15H2,1H3/t22-/m0/s1
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay

J Med Chem 52: 105-16 (2009)


Article DOI: 10.1021/jm801144h
BindingDB Entry DOI: 10.7270/Q2NZ87HT
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-3


(Homo sapiens (Human))		BDBM50265546
PNG
(CHEMBL447079 | N-{1-[1-(2,2-Dimethylpropanoyl)-L-p...)
Show SMILES CC(C)(C)C(=O)N1CCC[C@H]1C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1 |r|
Show InChI InChI=1S/C28H34F3N3O6S2/c1-27(2,3)26(36)34-15-7-10-23(34)25(35)33-16-13-19(14-17-33)32-42(39,40)24-18-21(11-12-22(24)28(29,30)31)41(37,38)20-8-5-4-6-9-20/h4-6,8-9,11-12,18-19,23,32H,7,10,13-17H2,1-3H3/t23-/m0/s1
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n/an/an/an/a 270n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay

J Med Chem 52: 105-16 (2009)


Article DOI: 10.1021/jm801144h
BindingDB Entry DOI: 10.7270/Q2NZ87HT
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-3


(Homo sapiens (Human))		BDBM50265581
PNG
(CHEMBL505036 | N-{1-[1-(Morpholin-4-ylcarbonyl)-L-...)
Show SMILES FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)[C@@H]1CCCN1C(=O)N1CCOCC1)S(=O)(=O)c1ccccc1 |r|
Show InChI InChI=1S/C28H33F3N4O7S2/c29-28(30,31)23-9-8-22(43(38,39)21-5-2-1-3-6-21)19-25(23)44(40,41)32-20-10-13-33(14-11-20)26(36)24-7-4-12-35(24)27(37)34-15-17-42-18-16-34/h1-3,5-6,8-9,19-20,24,32H,4,7,10-18H2/t24-/m0/s1
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay

J Med Chem 52: 105-16 (2009)


Article DOI: 10.1021/jm801144h
BindingDB Entry DOI: 10.7270/Q2NZ87HT
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-3


(Homo sapiens (Human))		BDBM50265469
PNG
(CHEMBL497383 | N-[1-(N,N-Dimethylglycyl)piperidin-...)
Show SMILES CN(C)CC(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C22H26F3N3O5S2/c1-27(2)15-21(29)28-12-10-16(11-13-28)26-35(32,33)20-14-18(8-9-19(20)22(23,24)25)34(30,31)17-6-4-3-5-7-17/h3-9,14,16,26H,10-13,15H2,1-2H3
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay

J Med Chem 52: 105-16 (2009)


Article DOI: 10.1021/jm801144h
BindingDB Entry DOI: 10.7270/Q2NZ87HT
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-3


(Homo sapiens (Human))		BDBM50265555
PNG
((2S)-N-Phenyl-2-{[4-({[5-(phenylsulfonyl)-2-(trifl...)
Show SMILES FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1)S(=O)(=O)c1ccccc1 |r|
Show InChI InChI=1S/C30H31F3N4O6S2/c31-30(32,33)25-14-13-24(44(40,41)23-10-5-2-6-11-23)20-27(25)45(42,43)35-22-15-18-36(19-16-22)28(38)26-12-7-17-37(26)29(39)34-21-8-3-1-4-9-21/h1-6,8-11,13-14,20,22,26,35H,7,12,15-19H2,(H,34,39)/t26-/m0/s1
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay

J Med Chem 52: 105-16 (2009)


Article DOI: 10.1021/jm801144h
BindingDB Entry DOI: 10.7270/Q2NZ87HT
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-3


(Homo sapiens (Human))		BDBM50265548
PNG
(CHEMBL501332 | N-[1-(N,N-Dimethylglycyl-L-prolyl)p...)
Show SMILES CN(C)CC(=O)N1CCC[C@H]1C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1 |r|
Show InChI InChI=1S/C27H33F3N4O6S2/c1-32(2)18-25(35)34-14-6-9-23(34)26(36)33-15-12-19(13-16-33)31-42(39,40)24-17-21(10-11-22(24)27(28,29)30)41(37,38)20-7-4-3-5-8-20/h3-5,7-8,10-11,17,19,23,31H,6,9,12-16,18H2,1-2H3/t23-/m0/s1
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay

J Med Chem 52: 105-16 (2009)


Article DOI: 10.1021/jm801144h
BindingDB Entry DOI: 10.7270/Q2NZ87HT
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-3


(Homo sapiens (Human))		BDBM50265584
PNG
(CHEMBL503281 | N-{1-[1-(Cyclohexylmethyl)-L-prolyl...)
Show SMILES FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)[C@@H]1CCCN1CC1CCCCC1)S(=O)(=O)c1ccccc1 |r|
Show InChI InChI=1S/C30H38F3N3O5S2/c31-30(32,33)26-14-13-25(42(38,39)24-10-5-2-6-11-24)20-28(26)43(40,41)34-23-15-18-35(19-16-23)29(37)27-12-7-17-36(27)21-22-8-3-1-4-9-22/h2,5-6,10-11,13-14,20,22-23,27,34H,1,3-4,7-9,12,15-19,21H2/t27-/m0/s1
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay

J Med Chem 52: 105-16 (2009)


Article DOI: 10.1021/jm801144h
BindingDB Entry DOI: 10.7270/Q2NZ87HT
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-3


(Homo sapiens (Human))		BDBM50265503
PNG
((S)-5-(phenylsulfonyl)-N-(1-(pyrrolidine-2-carbony...)
Show SMILES FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)[C@@H]1CCCN1)S(=O)(=O)c1ccccc1 |r|
Show InChI InChI=1S/C23H26F3N3O5S2/c24-23(25,26)19-9-8-18(35(31,32)17-5-2-1-3-6-17)15-21(19)36(33,34)28-16-10-13-29(14-11-16)22(30)20-7-4-12-27-20/h1-3,5-6,8-9,15-16,20,27-28H,4,7,10-14H2/t20-/m0/s1
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay

J Med Chem 52: 105-16 (2009)


Article DOI: 10.1021/jm801144h
BindingDB Entry DOI: 10.7270/Q2NZ87HT
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-3


(Homo sapiens (Human))		BDBM50265552
PNG
(CHEMBL454478 | N-[1-(1-Isonicotinoyl-L-prolyl)pipe...)
Show SMILES FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)[C@@H]1CCCN1C(=O)c1ccncc1)S(=O)(=O)c1ccccc1 |r|
Show InChI InChI=1S/C29H29F3N4O6S2/c30-29(31,32)24-9-8-23(43(39,40)22-5-2-1-3-6-22)19-26(24)44(41,42)34-21-12-17-35(18-13-21)28(38)25-7-4-16-36(25)27(37)20-10-14-33-15-11-20/h1-3,5-6,8-11,14-15,19,21,25,34H,4,7,12-13,16-18H2/t25-/m0/s1
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay

J Med Chem 52: 105-16 (2009)


Article DOI: 10.1021/jm801144h
BindingDB Entry DOI: 10.7270/Q2NZ87HT
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-3


(Homo sapiens (Human))		BDBM50265550
PNG
(CHEMBL510748 | N-[1-(1-Benzoyl-L-prolyl)piperidin-...)
Show SMILES FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)[C@@H]1CCCN1C(=O)c1ccccc1)S(=O)(=O)c1ccccc1 |r|
Show InChI InChI=1S/C30H30F3N3O6S2/c31-30(32,33)25-14-13-24(43(39,40)23-10-5-2-6-11-23)20-27(25)44(41,42)34-22-15-18-35(19-16-22)29(38)26-12-7-17-36(26)28(37)21-8-3-1-4-9-21/h1-6,8-11,13-14,20,22,26,34H,7,12,15-19H2/t26-/m0/s1
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay

J Med Chem 52: 105-16 (2009)


Article DOI: 10.1021/jm801144h
BindingDB Entry DOI: 10.7270/Q2NZ87HT
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-3


(Homo sapiens (Human))		BDBM50294827
PNG
(4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*...)
Show SMILES O=C(Nc1cccc2cccnc12)[C@H]1CC[C@@H](CC1)N1C(=O)[C@H]2[C@@H]3C[C@@H](C=C3)[C@H]2C1=O |r,wU:23.26,25.27,13.14,wD:16.21,22.24,28.33,c:29,(23.31,2.86,;22.53,1.53,;23.3,.19,;24.84,.19,;25.62,1.52,;27.17,1.52,;27.93,.18,;27.16,-1.15,;27.93,-2.48,;27.17,-3.81,;25.62,-3.82,;24.85,-2.48,;25.62,-1.15,;20.99,1.53,;20.23,.2,;18.69,.2,;17.91,1.54,;18.69,2.87,;20.23,2.87,;16.37,1.54,;15.47,2.78,;15.94,4.25,;14,2.3,;12.68,3.07,;13.06,1.59,;12.65,.11,;11.33,.77,;11.34,2.31,;14,.76,;15.46,.29,;15.94,-1.18,)|
Show InChI InChI=1S/C25H25N3O3/c29-23(27-19-5-1-3-14-4-2-12-26-22(14)19)15-8-10-18(11-9-15)28-24(30)20-16-6-7-17(13-16)21(20)25(28)31/h1-7,12,15-18,20-21H,8-11,13H2,(H,27,29)/t15-,16-,17+,18-,20-,21+
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The University of Texas Southwestern Medical Center at Dallas

Curated by ChEMBL


Assay Description
Inhibition of Wnt3 expressed in mouse L-cells assessed as inhibition of Wnt/catanin signaling pathway by luciferase reporter gene assay

Bioorg Med Chem Lett 19: 3825-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.040
BindingDB Entry DOI: 10.7270/Q2DZ08BS
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-3


(Homo sapiens (Human))		BDBM50265583
PNG
(CHEMBL451431 | N-{1-[1-(3,3-Dimethylbutyl)-L-proly...)
Show SMILES CC(C)(C)CCN1CCC[C@H]1C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1 |r|
Show InChI InChI=1S/C29H38F3N3O5S2/c1-28(2,3)15-19-34-16-7-10-25(34)27(36)35-17-13-21(14-18-35)33-42(39,40)26-20-23(11-12-24(26)29(30,31)32)41(37,38)22-8-5-4-6-9-22/h4-6,8-9,11-12,20-21,25,33H,7,10,13-19H2,1-3H3/t25-/m0/s1
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay

J Med Chem 52: 105-16 (2009)


Article DOI: 10.1021/jm801144h
BindingDB Entry DOI: 10.7270/Q2NZ87HT
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-3


(Homo sapiens (Human))		BDBM50265549
PNG
(CHEMBL507695 | N-{1-[1-(Cyclohexylcarbonyl)-L-prol...)
Show SMILES FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)[C@@H]1CCCN1C(=O)C1CCCCC1)S(=O)(=O)c1ccccc1 |r|
Show InChI InChI=1S/C30H36F3N3O6S2/c31-30(32,33)25-14-13-24(43(39,40)23-10-5-2-6-11-23)20-27(25)44(41,42)34-22-15-18-35(19-16-22)29(38)26-12-7-17-36(26)28(37)21-8-3-1-4-9-21/h2,5-6,10-11,13-14,20-22,26,34H,1,3-4,7-9,12,15-19H2/t26-/m0/s1
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay

J Med Chem 52: 105-16 (2009)


Article DOI: 10.1021/jm801144h
BindingDB Entry DOI: 10.7270/Q2NZ87HT
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-3


(Homo sapiens (Human))		BDBM50265468
PNG
(CHEMBL497177 | N-[1-(N-Methylglycyl)piperidin-4-yl...)
Show SMILES CNCC(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C21H24F3N3O5S2/c1-25-14-20(28)27-11-9-15(10-12-27)26-34(31,32)19-13-17(7-8-18(19)21(22,23)24)33(29,30)16-5-3-2-4-6-16/h2-8,13,15,25-26H,9-12,14H2,1H3
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay

J Med Chem 52: 105-16 (2009)


Article DOI: 10.1021/jm801144h
BindingDB Entry DOI: 10.7270/Q2NZ87HT
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-3


(Homo sapiens (Human))		BDBM50265467
PNG
(5-(Phenylsulfonyl)-N-piperidin-4-yl-2-(trifluorome...)
Show SMILES FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCNCC1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C18H19F3N2O4S2/c19-18(20,21)16-7-6-15(28(24,25)14-4-2-1-3-5-14)12-17(16)29(26,27)23-13-8-10-22-11-9-13/h1-7,12-13,22-23H,8-11H2
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay

J Med Chem 52: 105-16 (2009)


Article DOI: 10.1021/jm801144h
BindingDB Entry DOI: 10.7270/Q2NZ87HT
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-3


(Homo sapiens (Human))		BDBM50265504
PNG
((R)-5-(phenylsulfonyl)-N-(1-(pyrrolidine-2-carbony...)
Show SMILES FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)[C@H]1CCCN1)S(=O)(=O)c1ccccc1 |r|
Show InChI InChI=1S/C23H26F3N3O5S2/c24-23(25,26)19-9-8-18(35(31,32)17-5-2-1-3-6-17)15-21(19)36(33,34)28-16-10-13-29(14-11-16)22(30)20-7-4-12-27-20/h1-3,5-6,8-9,15-16,20,27-28H,4,7,10-14H2/t20-/m1/s1
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay

J Med Chem 52: 105-16 (2009)


Article DOI: 10.1021/jm801144h
BindingDB Entry DOI: 10.7270/Q2NZ87HT
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-3


(Homo sapiens (Human))		BDBM50265585
PNG
(CHEMBL511077 | N-[1-(1-Benzyl-L-prolyl)piperidin-4...)
Show SMILES FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)[C@@H]1CCCN1Cc1ccccc1)S(=O)(=O)c1ccccc1 |r|
Show InChI InChI=1S/C30H32F3N3O5S2/c31-30(32,33)26-14-13-25(42(38,39)24-10-5-2-6-11-24)20-28(26)43(40,41)34-23-15-18-35(19-16-23)29(37)27-12-7-17-36(27)21-22-8-3-1-4-9-22/h1-6,8-11,13-14,20,23,27,34H,7,12,15-19,21H2/t27-/m0/s1
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay

J Med Chem 52: 105-16 (2009)


Article DOI: 10.1021/jm801144h
BindingDB Entry DOI: 10.7270/Q2NZ87HT
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-3


(Homo sapiens (Human))		BDBM50294787
PNG
(4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*...)
Show SMILES Cc1ccc2cccnc2c1NC(=O)c1ccc(cc1)-n1c(O)c2[C@H]3C[C@H](C=C3)c2c1O |r,c:30|
Show InChI InChI=1S/C26H21N3O3/c1-14-4-5-15-3-2-12-27-23(15)22(14)28-24(30)16-8-10-19(11-9-16)29-25(31)20-17-6-7-18(13-17)21(20)26(29)32/h2-12,17-18,31-32H,13H2,1H3,(H,28,30)/t17-,18+
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n/an/an/an/a 800n/an/an/an/a



The University of Texas Southwestern Medical Center at Dallas

Curated by ChEMBL


Assay Description
Inhibition of Wnt3 expressed in mouse L-cells assessed as inhibition of Wnt/catanin signaling pathway by luciferase reporter gene assay

Bioorg Med Chem Lett 19: 3825-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.040
BindingDB Entry DOI: 10.7270/Q2DZ08BS
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-3


(Homo sapiens (Human))		BDBM50265551
PNG
(CHEMBL462363 | N-(1-{1-[4-(Dimethylamino)benzoyl]-...)
Show SMILES CN(C)c1ccc(cc1)C(=O)N1CCC[C@H]1C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1 |r|
Show InChI InChI=1S/C32H35F3N4O6S2/c1-37(2)24-12-10-22(11-13-24)30(40)39-18-6-9-28(39)31(41)38-19-16-23(17-20-38)36-47(44,45)29-21-26(14-15-27(29)32(33,34)35)46(42,43)25-7-4-3-5-8-25/h3-5,7-8,10-15,21,23,28,36H,6,9,16-20H2,1-2H3/t28-/m0/s1
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n/an/an/an/a 830n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay

J Med Chem 52: 105-16 (2009)


Article DOI: 10.1021/jm801144h
BindingDB Entry DOI: 10.7270/Q2NZ87HT
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-3


(Homo sapiens (Human))		BDBM50294789
PNG
(4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*...)
Show SMILES COc1ccccc1NC(=O)c1ccc(cc1)-n1c(O)c2[C@H]3C[C@H](C=C3)c2c1O |r,c:26|
Show InChI InChI=1S/C23H20N2O4/c1-29-18-5-3-2-4-17(18)24-21(26)13-8-10-16(11-9-13)25-22(27)19-14-6-7-15(12-14)20(19)23(25)28/h2-11,14-15,27-28H,12H2,1H3,(H,24,26)/t14-,15+
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n/an/an/an/a 1.00E+3n/an/an/an/a



The University of Texas Southwestern Medical Center at Dallas

Curated by ChEMBL


Assay Description
Inhibition of Wnt3 expressed in mouse L-cells assessed as inhibition of Wnt/catanin signaling pathway by luciferase reporter gene assay

Bioorg Med Chem Lett 19: 3825-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.040
BindingDB Entry DOI: 10.7270/Q2DZ08BS
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-3


(Homo sapiens (Human))		BDBM50294829
PNG
(4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*...)
Show SMILES Cc1ccc2cccnc2c1NC(=O)[C@H]1CC[C@@H](CC1)N1C(=O)[C@H]2[C@@H]3C[C@@H](C=C3)[C@H]2C1=O |r,wU:24.27,26.28,14.15,wD:23.25,29.34,17.22,c:30,(24.21,-7.63,;24.97,-8.97,;26.52,-8.98,;27.29,-10.31,;26.52,-11.64,;27.29,-12.97,;26.52,-14.31,;24.97,-14.31,;24.2,-12.98,;24.97,-11.64,;24.2,-10.3,;22.66,-10.3,;21.89,-8.97,;22.66,-7.63,;20.35,-8.96,;19.58,-10.3,;18.04,-10.3,;17.27,-8.95,;18.04,-7.62,;19.58,-7.63,;15.73,-8.95,;14.82,-7.72,;15.3,-6.25,;13.36,-8.19,;12.03,-7.42,;12.42,-8.91,;12,-10.39,;10.69,-9.72,;10.69,-8.18,;13.35,-9.73,;14.82,-10.21,;15.29,-11.68,)|
Show InChI InChI=1S/C26H27N3O3/c1-14-4-5-15-3-2-12-27-23(15)22(14)28-24(30)16-8-10-19(11-9-16)29-25(31)20-17-6-7-18(13-17)21(20)26(29)32/h2-7,12,16-21H,8-11,13H2,1H3,(H,28,30)/t16-,17-,18+,19-,20-,21+
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n/an/an/an/a 1.00E+3n/an/an/an/a



The University of Texas Southwestern Medical Center at Dallas

Curated by ChEMBL


Assay Description
Inhibition of Wnt3 expressed in mouse L-cells assessed as inhibition of Wnt/catanin signaling pathway by luciferase reporter gene assay

Bioorg Med Chem Lett 19: 3825-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.040
BindingDB Entry DOI: 10.7270/Q2DZ08BS
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-3


(Homo sapiens (Human))		BDBM50294828
PNG
(4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*...)
Show SMILES Cc1ccnc2c(NC(=O)[C@H]3CC[C@@H](CC3)N3C(=O)[C@H]4[C@@H]5C[C@@H](C=C5)[C@H]4C3=O)cccc12 |r,wU:20.21,22.22,10.9,wD:19.19,25.28,13.16,c:24,(7.08,-13.51,;5.54,-13.51,;4.77,-14.84,;3.22,-14.85,;2.45,-13.51,;3.22,-12.18,;2.45,-10.84,;.9,-10.84,;.14,-9.5,;.91,-8.17,;-1.41,-9.5,;-2.17,-10.83,;-3.71,-10.83,;-4.48,-9.49,;-3.71,-8.16,;-2.17,-8.16,;-6.02,-9.49,;-6.93,-8.25,;-6.46,-6.78,;-8.39,-8.73,;-9.72,-7.96,;-9.33,-9.44,;-9.75,-10.92,;-11.06,-10.26,;-11.06,-8.72,;-8.4,-10.27,;-6.93,-10.75,;-6.46,-12.21,;3.22,-9.51,;4.77,-9.51,;5.54,-10.85,;4.77,-12.18,)|
Show InChI InChI=1S/C26H27N3O3/c1-14-11-12-27-23-19(14)3-2-4-20(23)28-24(30)15-7-9-18(10-8-15)29-25(31)21-16-5-6-17(13-16)22(21)26(29)32/h2-6,11-12,15-18,21-22H,7-10,13H2,1H3,(H,28,30)/t15-,16-,17+,18-,21-,22+
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n/an/an/an/a 1.00E+3n/an/an/an/a



The University of Texas Southwestern Medical Center at Dallas

Curated by ChEMBL


Assay Description
Inhibition of Wnt3 expressed in mouse L-cells assessed as inhibition of Wnt/catanin signaling pathway by luciferase reporter gene assay

Bioorg Med Chem Lett 19: 3825-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.040
BindingDB Entry DOI: 10.7270/Q2DZ08BS
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-3


(Homo sapiens (Human))		BDBM50294823
PNG
(2-Chloro-4-((1R,2S,6R,7S)-3,5-dioxo-4-aza-tricyclo...)
Show SMILES Oc1c2[C@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(C(=O)Nc2cccc3cccnc23)c(Cl)c1 |r,c:6|
Show InChI InChI=1S/C25H18ClN3O3/c26-18-12-16(29-24(31)20-14-6-7-15(11-14)21(20)25(29)32)8-9-17(18)23(30)28-19-5-1-3-13-4-2-10-27-22(13)19/h1-10,12,14-15,31-32H,11H2,(H,28,30)/t14-,15+
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n/an/an/an/a 1.00E+3n/an/an/an/a



The University of Texas Southwestern Medical Center at Dallas

Curated by ChEMBL


Assay Description
Inhibition of Wnt3 expressed in mouse L-cells assessed as inhibition of Wnt/catanin signaling pathway by luciferase reporter gene assay

Bioorg Med Chem Lett 19: 3825-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.040
BindingDB Entry DOI: 10.7270/Q2DZ08BS
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-3


(Homo sapiens (Human))		BDBM50294799
PNG
(CHEMBL551249 | N-(4-Bromo-phenyl)-4-((1R,2S,6R,7S)...)
Show SMILES Oc1c2[C@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(cc1)C(=O)Nc1ccc(Br)cc1 |r,c:6|
Show InChI InChI=1S/C22H17BrN2O3/c23-15-5-7-16(8-6-15)24-20(26)12-3-9-17(10-4-12)25-21(27)18-13-1-2-14(11-13)19(18)22(25)28/h1-10,13-14,27-28H,11H2,(H,24,26)/t13-,14+
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n/an/an/an/a 1.00E+3n/an/an/an/a



The University of Texas Southwestern Medical Center at Dallas

Curated by ChEMBL


Assay Description
Inhibition of Wnt3 expressed in mouse L-cells assessed as inhibition of Wnt/catanin signaling pathway by luciferase reporter gene assay

Bioorg Med Chem Lett 19: 3825-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.040
BindingDB Entry DOI: 10.7270/Q2DZ08BS
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-3


(Homo sapiens (Human))		BDBM50294817
PNG
(CHEMBL549349 | trans-4-((1R,2S,6R,7S)-3,5-Dioxo-4-...)
Show SMILES CO[C@@H]1CCCC[C@H]1NC(=O)c1ccc(cc1)-n1c(O)c2[C@H]3C[C@H](C=C3)c2c1O |r,c:26|
Show InChI InChI=1S/C23H26N2O4/c1-29-18-5-3-2-4-17(18)24-21(26)13-8-10-16(11-9-13)25-22(27)19-14-6-7-15(12-14)20(19)23(25)28/h6-11,14-15,17-18,27-28H,2-5,12H2,1H3,(H,24,26)/t14-,15+,17-,18-/m1/s1
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n/an/an/an/a 2.00E+3n/an/an/an/a



The University of Texas Southwestern Medical Center at Dallas

Curated by ChEMBL


Assay Description
Inhibition of Wnt3 expressed in mouse L-cells assessed as inhibition of Wnt/catanin signaling pathway by luciferase reporter gene assay

Bioorg Med Chem Lett 19: 3825-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.040
BindingDB Entry DOI: 10.7270/Q2DZ08BS
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-3


(Homo sapiens (Human))		BDBM50294824
PNG
(4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*...)
Show SMILES Cc1cc(ccc1C(=O)Nc1cccc2cccnc12)-n1c(O)c2[C@H]3C[C@H](C=C3)c2c1O |r,c:30|
Show InChI InChI=1S/C26H21N3O3/c1-14-12-18(29-25(31)21-16-7-8-17(13-16)22(21)26(29)32)9-10-19(14)24(30)28-20-6-2-4-15-5-3-11-27-23(15)20/h2-12,16-17,31-32H,13H2,1H3,(H,28,30)/t16-,17+
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n/an/an/an/a 2.00E+3n/an/an/an/a



The University of Texas Southwestern Medical Center at Dallas

Curated by ChEMBL


Assay Description
Inhibition of Wnt3 expressed in mouse L-cells assessed as inhibition of Wnt/catanin signaling pathway by luciferase reporter gene assay

Bioorg Med Chem Lett 19: 3825-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.040
BindingDB Entry DOI: 10.7270/Q2DZ08BS
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-3


(Homo sapiens (Human))		BDBM50294806
PNG
(CHEMBL564614 | N-(3,4-Difluoro-phenyl)-4-((1R,2S,6...)
Show SMILES Oc1c2[C@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(cc1)C(=O)Nc1ccc(F)c(F)c1 |r,c:6|
Show InChI InChI=1S/C22H16F2N2O3/c23-16-8-5-14(10-17(16)24)25-20(27)11-3-6-15(7-4-11)26-21(28)18-12-1-2-13(9-12)19(18)22(26)29/h1-8,10,12-13,28-29H,9H2,(H,25,27)/t12-,13+
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n/an/an/an/a 3.00E+3n/an/an/an/a



The University of Texas Southwestern Medical Center at Dallas

Curated by ChEMBL


Assay Description
Inhibition of Wnt3 expressed in mouse L-cells assessed as inhibition of Wnt/catanin signaling pathway by luciferase reporter gene assay

Bioorg Med Chem Lett 19: 3825-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.040
BindingDB Entry DOI: 10.7270/Q2DZ08BS
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-3


(Homo sapiens (Human))		BDBM50294798
PNG
(CHEMBL560712 | N-(4-Chloro-phenyl)-4-((1R,2S,6R,7S...)
Show SMILES Oc1c2[C@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(cc1)C(=O)Nc1ccc(Cl)cc1 |r,c:6|
Show InChI InChI=1S/C22H17ClN2O3/c23-15-5-7-16(8-6-15)24-20(26)12-3-9-17(10-4-12)25-21(27)18-13-1-2-14(11-13)19(18)22(25)28/h1-10,13-14,27-28H,11H2,(H,24,26)/t13-,14+
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n/an/an/an/a 3.00E+3n/an/an/an/a



The University of Texas Southwestern Medical Center at Dallas

Curated by ChEMBL


Assay Description
Inhibition of Wnt3 expressed in mouse L-cells assessed as inhibition of Wnt/catanin signaling pathway by luciferase reporter gene assay

Bioorg Med Chem Lett 19: 3825-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.040
BindingDB Entry DOI: 10.7270/Q2DZ08BS
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-3


(Homo sapiens (Human))		BDBM50294797
PNG
(4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*...)
Show SMILES Oc1c2[C@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(cc1)C(=O)Nc1ccc(F)cc1 |r,c:6|
Show InChI InChI=1S/C22H17FN2O3/c23-15-5-7-16(8-6-15)24-20(26)12-3-9-17(10-4-12)25-21(27)18-13-1-2-14(11-13)19(18)22(25)28/h1-10,13-14,27-28H,11H2,(H,24,26)/t13-,14+
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n/an/an/an/a 4.00E+3n/an/an/an/a



The University of Texas Southwestern Medical Center at Dallas

Curated by ChEMBL


Assay Description
Inhibition of Wnt3 expressed in mouse L-cells assessed as inhibition of Wnt/catanin signaling pathway by luciferase reporter gene assay

Bioorg Med Chem Lett 19: 3825-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.040
BindingDB Entry DOI: 10.7270/Q2DZ08BS
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-3


(Homo sapiens (Human))		BDBM50294807
PNG
(CHEMBL563015 | N-(3,4-Dichloro-phenyl)-4-((1R,2S,6...)
Show SMILES Oc1c2[C@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(cc1)C(=O)Nc1ccc(Cl)c(Cl)c1 |r,c:6|
Show InChI InChI=1S/C22H16Cl2N2O3/c23-16-8-5-14(10-17(16)24)25-20(27)11-3-6-15(7-4-11)26-21(28)18-12-1-2-13(9-12)19(18)22(26)29/h1-8,10,12-13,28-29H,9H2,(H,25,27)/t12-,13+
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n/an/an/an/a 5.00E+3n/an/an/an/a



The University of Texas Southwestern Medical Center at Dallas

Curated by ChEMBL


Assay Description
Inhibition of Wnt3 expressed in mouse L-cells assessed as inhibition of Wnt/catanin signaling pathway by luciferase reporter gene assay

Bioorg Med Chem Lett 19: 3825-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.040
BindingDB Entry DOI: 10.7270/Q2DZ08BS
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-3


(Homo sapiens (Human))		BDBM50294835
PNG
(4-((1S,2S,6R,7R)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*...)
Show SMILES Oc1c2[C@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(cc1)C(=O)Nc1cccc2cccnc12 |r,c:6|
Show InChI InChI=1S/C25H19N3O3/c29-23(27-19-5-1-3-14-4-2-12-26-22(14)19)15-8-10-18(11-9-15)28-24(30)20-16-6-7-17(13-16)21(20)25(28)31/h1-12,16-17,30-31H,13H2,(H,27,29)/t16-,17+
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n/an/an/an/a 5.00E+3n/an/an/an/a



The University of Texas Southwestern Medical Center at Dallas

Curated by ChEMBL


Assay Description
Inhibition of Wnt3 expressed in mouse L-cells assessed as inhibition of Wnt/catanin signaling pathway by luciferase reporter gene assay

Bioorg Med Chem Lett 19: 3825-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.040
BindingDB Entry DOI: 10.7270/Q2DZ08BS
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-3


(Homo sapiens (Human))		BDBM50294796
PNG
(CHEMBL552187 | N-(3-Bromo-phenyl)-4-((1R,2S,6R,7S)...)
Show SMILES Oc1c2[C@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(cc1)C(=O)Nc1cccc(Br)c1 |r,c:6|
Show InChI InChI=1S/C22H17BrN2O3/c23-15-2-1-3-16(11-15)24-20(26)12-6-8-17(9-7-12)25-21(27)18-13-4-5-14(10-13)19(18)22(25)28/h1-9,11,13-14,27-28H,10H2,(H,24,26)/t13-,14+
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n/an/an/an/a 9.00E+3n/an/an/an/a



The University of Texas Southwestern Medical Center at Dallas

Curated by ChEMBL


Assay Description
Inhibition of Wnt3 expressed in mouse L-cells assessed as inhibition of Wnt/catanin signaling pathway by luciferase reporter gene assay

Bioorg Med Chem Lett 19: 3825-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.040
BindingDB Entry DOI: 10.7270/Q2DZ08BS
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-3


(Homo sapiens (Human))		BDBM50294801
PNG
(CHEMBL550093 | N-(2,4-Difluoro-phenyl)-4-((1R,2S,6...)
Show SMILES Oc1c2[C@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(cc1)C(=O)Nc1ccc(F)cc1F |r,c:6|
Show InChI InChI=1S/C22H16F2N2O3/c23-14-5-8-17(16(24)10-14)25-20(27)11-3-6-15(7-4-11)26-21(28)18-12-1-2-13(9-12)19(18)22(26)29/h1-8,10,12-13,28-29H,9H2,(H,25,27)/t12-,13+
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n/an/an/an/a 9.00E+3n/an/an/an/a



The University of Texas Southwestern Medical Center at Dallas

Curated by ChEMBL


Assay Description
Inhibition of Wnt3 expressed in mouse L-cells assessed as inhibition of Wnt/catanin signaling pathway by luciferase reporter gene assay

Bioorg Med Chem Lett 19: 3825-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.040
BindingDB Entry DOI: 10.7270/Q2DZ08BS
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-3


(Homo sapiens (Human))		BDBM50294833
PNG
(4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*...)
Show SMILES Cc1ccc2cccnc2c1NC(=O)[C@H]1CC[C@H](CN2C(=O)[C@H]3[C@@H]4C[C@@H](C=C4)[C@H]3C2=O)CC1 |r,wU:23.25,25.26,14.15,wD:17.19,22.23,28.32,c:28,(26.79,-33.52,;26.76,-35.06,;28.09,-35.86,;28.07,-37.4,;26.73,-38.15,;26.72,-39.69,;25.38,-40.45,;24.04,-39.66,;24.06,-38.12,;25.4,-37.36,;25.42,-35.81,;24.09,-35.03,;24.11,-33.49,;25.46,-32.73,;22.79,-32.7,;21.45,-33.45,;20.13,-32.67,;20.14,-31.12,;18.82,-30.33,;17.28,-30.34,;16.38,-29.1,;16.85,-27.63,;14.91,-29.58,;13.59,-28.81,;13.97,-30.29,;13.56,-31.77,;12.25,-31.11,;12.25,-29.57,;14.91,-31.12,;16.37,-31.59,;16.85,-33.06,;21.49,-30.37,;22.81,-31.16,)|
Show InChI InChI=1S/C27H29N3O3/c1-15-4-7-17-3-2-12-28-24(17)23(15)29-25(31)18-8-5-16(6-9-18)14-30-26(32)21-19-10-11-20(13-19)22(21)27(30)33/h2-4,7,10-12,16,18-22H,5-6,8-9,13-14H2,1H3,(H,29,31)/t16-,18-,19-,20+,21-,22+
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n/an/an/an/a 1.00E+4n/an/an/an/a



The University of Texas Southwestern Medical Center at Dallas

Curated by ChEMBL


Assay Description
Inhibition of Wnt3 expressed in mouse L-cells assessed as inhibition of Wnt/catanin signaling pathway by luciferase reporter gene assay

Bioorg Med Chem Lett 19: 3825-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.040
BindingDB Entry DOI: 10.7270/Q2DZ08BS
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-3


(Homo sapiens (Human))		BDBM50294808
PNG
(CHEMBL554302 | N-(3,4-Dibromo-phenyl)-4-((1R,2S,6R...)
Show SMILES Oc1c2[C@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(cc1)C(=O)Nc1ccc(Br)c(Br)c1 |r,c:6|
Show InChI InChI=1S/C22H16Br2N2O3/c23-16-8-5-14(10-17(16)24)25-20(27)11-3-6-15(7-4-11)26-21(28)18-12-1-2-13(9-12)19(18)22(26)29/h1-8,10,12-13,28-29H,9H2,(H,25,27)/t12-,13+
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n/an/an/an/a 1.00E+4n/an/an/an/a



The University of Texas Southwestern Medical Center at Dallas

Curated by ChEMBL


Assay Description
Inhibition of Wnt3 expressed in mouse L-cells assessed as inhibition of Wnt/catanin signaling pathway by luciferase reporter gene assay

Bioorg Med Chem Lett 19: 3825-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.040
BindingDB Entry DOI: 10.7270/Q2DZ08BS
More data for this
Ligand-Target Pair
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