Found 52 hits of ec50 for UniProtKB: P32301 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Glucagon-like peptide 1 receptor
(Rattus norvegicus) | BDBM50604669
(CHEMBL5208485)Show SMILES FC(F)(F)c1ccc(cc1)-c1noc(CN2CCCC(CN3CCOCC3)C2)n1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet 
| Purchase
MCE
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.00800 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01842
BindingDB Entry DOI: 10.7270/Q22V2M6R |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Rattus norvegicus) | BDBM50393580
(CHEMBL2158410)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O |r| Show InChI InChI=1S/C186H275N51O59/c1-17-94(10)149(182(294)209-98(14)155(267)220-128(73-105-78-199-111-42-28-27-41-109(105)111)171(283)223-123(68-91(4)5)173(285)234-147(92(6)7)180(292)219-113(43-29-31-63-187)158(270)200-81-136(245)210-112(45-33-65-197-185(191)192)157(269)203-84-146(262)263)236-174(286)126(70-102-37-23-19-24-38-102)225-165(277)120(55-61-142(254)255)216-162(274)114(44-30-32-64-188)212-153(265)96(12)206-152(264)95(11)207-161(273)118(51-57-135(190)244)211-137(246)82-201-160(272)117(53-59-140(250)251)215-168(280)122(67-90(2)3)222-170(282)125(72-104-47-49-108(243)50-48-104)226-177(289)132(85-238)230-179(291)134(87-240)231-181(293)148(93(8)9)235-176(288)131(77-145(260)261)228-178(290)133(86-239)232-184(296)151(100(16)242)237-175(287)127(71-103-39-25-20-26-40-103)229-183(295)150(99(15)241)233-138(247)83-202-159(271)116(52-58-139(248)249)213-154(266)97(13)208-167(279)129(75-107-80-196-89-205-107)227-163(275)115(46-34-66-198-186(193)194)214-164(276)119(54-60-141(252)253)217-169(281)124(69-101-35-21-18-22-36-101)224-166(278)121(56-62-143(256)257)218-172(284)130(76-144(258)259)221-156(268)110(189)74-106-79-195-88-204-106/h18-28,35-42,47-50,78-80,88-100,110,112-134,147-151,199,238-243H,17,29-34,43-46,51-77,81-87,187-189H2,1-16H3,(H2,190,244)(H,195,204)(H,196,205)(H,200,270)(H,201,272)(H,202,271)(H,203,269)(H,206,264)(H,207,273)(H,208,279)(H,209,294)(H,210,245)(H,211,246)(H,212,265)(H,213,266)(H,214,276)(H,215,280)(H,216,274)(H,217,281)(H,218,284)(H,219,292)(H,220,267)(H,221,268)(H,222,282)(H,223,283)(H,224,278)(H,225,277)(H,226,289)(H,227,275)(H,228,290)(H,229,295)(H,230,291)(H,231,293)(H,232,296)(H,233,247)(H,234,285)(H,235,288)(H,236,286)(H,237,287)(H,248,249)(H,250,251)(H,252,253)(H,254,255)(H,256,257)(H,258,259)(H,260,261)(H,262,263)(H4,191,192,197)(H4,193,194,198)/t94-,95-,96-,97-,98-,99+,100+,110-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,147-,148-,149-,150-,151-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.0900 | n/a | n/a | n/a | n/a |
The National Center for Drug Screening
Curated by ChEMBL
| Assay Description
Agonist activity at rat GLP1R expressed in HEK293 cells assessed as stimulation of cAMP levels incubated for 6 hrs by multiple response element/cAMP ... |
J Med Chem 55: 250-67 (2012)
Article DOI: 10.1021/jm201150j
BindingDB Entry DOI: 10.7270/Q2M046JC |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Rattus norvegicus) | BDBM50557261
(CHEMBL4749279)Show SMILES CC[C@H](C)[C@H](NC(=O)C(Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1CCC[C@@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.120 | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at rat GLP-1R expressed in HEK293 cells assessed as stimulation of cAMP accumulation by FRET assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01783
BindingDB Entry DOI: 10.7270/Q2H41W34 |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Rattus norvegicus) | BDBM50604669
(CHEMBL5208485)Show SMILES FC(F)(F)c1ccc(cc1)-c1noc(CN2CCCC(CN3CCOCC3)C2)n1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.25 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01842
BindingDB Entry DOI: 10.7270/Q22V2M6R |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Rattus norvegicus) | BDBM50231948
(CHEMBL4066463)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O)C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O |r| Show InChI InChI=1S/C152H224N42O48/c1-13-75(6)121(149(240)179-94-37-24-27-52-160-112(203)61-104(131(222)166-67-114(205)172-91(38-28-54-162-152(157)158)129(220)164-66-111(156)202)187-148(239)120(74(4)5)192-142(233)99(55-73(2)3)180-139(230)103(183-135(94)226)59-85-64-163-90-34-21-20-33-88(85)90)193-143(234)101(56-82-29-16-14-17-30-82)181-137(228)98(46-50-118(211)212)177-134(225)92(35-22-25-51-153)173-125(216)77(8)168-124(215)76(7)170-132(223)96(43-47-110(155)201)175-127(218)79(10)171-133(224)97(45-49-117(209)210)178-140(231)105-62-113(204)161-53-26-23-36-93(136(227)188-108(70-196)147(238)189-107(69-195)145(236)182-100(138(229)184-105)58-84-39-41-87(200)42-40-84)176-141(232)106(63-119(213)214)185-146(237)109(71-197)190-151(242)123(81(12)199)194-144(235)102(57-83-31-18-15-19-32-83)186-150(241)122(80(11)198)191-115(206)68-165-130(221)95(44-48-116(207)208)174-126(217)78(9)169-128(219)89(154)60-86-65-159-72-167-86/h14-21,29-34,39-42,64-65,72-81,89,91-109,120-123,163,195-200H,13,22-28,35-38,43-63,66-71,153-154H2,1-12H3,(H2,155,201)(H2,156,202)(H,159,167)(H,160,203)(H,161,204)(H,164,220)(H,165,221)(H,166,222)(H,168,215)(H,169,219)(H,170,223)(H,171,224)(H,172,205)(H,173,216)(H,174,217)(H,175,218)(H,176,232)(H,177,225)(H,178,231)(H,179,240)(H,180,230)(H,181,228)(H,182,236)(H,183,226)(H,184,229)(H,185,237)(H,186,241)(H,187,239)(H,188,227)(H,189,238)(H,190,242)(H,191,206)(H,192,233)(H,193,234)(H,194,235)(H,207,208)(H,209,210)(H,211,212)(H,213,214)(H4,157,158,162)/t75-,76-,77-,78-,79-,80+,81+,89-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,120-,121-,122-,123-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.25 | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description
Agonist activity at GLP1R in rat INS-1 cells assessed as increase in glucose-stimulated insulin secretion after 1 hr by HTRF assay |
Eur J Med Chem 127: 703-714 (2017)
Article DOI: 10.1016/j.ejmech.2016.10.044
BindingDB Entry DOI: 10.7270/Q2T155W1 |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Rattus norvegicus) | BDBM50557264
(CHEMBL4751466)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.480 | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at rat GLP-1R expressed in HEK293 cells assessed as stimulation of cAMP accumulation by FRET assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01783
BindingDB Entry DOI: 10.7270/Q2H41W34 |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Rattus norvegicus) | BDBM50261506
(CHEMBL499930 | HAEGTFTSDVSSYLEGQAAKEFIAWLVKGRG-NH2)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O |r| Show InChI InChI=1S/C151H229N41O46/c1-17-77(10)121(148(236)170-81(14)127(215)178-105(60-87-63-161-92-36-25-24-35-90(87)92)138(226)180-101(56-74(4)5)139(227)189-119(75(6)7)146(234)177-94(37-26-28-52-152)130(218)163-66-112(201)171-93(39-30-54-160-151(157)158)129(217)162-65-111(156)200)191-140(228)103(57-84-31-20-18-21-32-84)181-135(223)99(47-51-117(208)209)176-134(222)95(38-27-29-53-153)173-125(213)79(12)167-124(212)78(11)169-133(221)98(44-48-110(155)199)172-113(202)67-164-132(220)97(46-50-116(206)207)175-136(224)100(55-73(2)3)179-137(225)102(59-86-40-42-89(198)43-41-86)182-143(231)107(69-193)185-145(233)109(71-195)186-147(235)120(76(8)9)190-142(230)106(62-118(210)211)183-144(232)108(70-194)187-150(238)123(83(16)197)192-141(229)104(58-85-33-22-19-23-34-85)184-149(237)122(82(15)196)188-114(203)68-165-131(219)96(45-49-115(204)205)174-126(214)80(13)168-128(216)91(154)61-88-64-159-72-166-88/h18-25,31-36,40-43,63-64,72-83,91,93-109,119-123,161,193-198H,17,26-30,37-39,44-62,65-71,152-154H2,1-16H3,(H2,155,199)(H2,156,200)(H,159,166)(H,162,217)(H,163,218)(H,164,220)(H,165,219)(H,167,212)(H,168,216)(H,169,221)(H,170,236)(H,171,201)(H,172,202)(H,173,213)(H,174,214)(H,175,224)(H,176,222)(H,177,234)(H,178,215)(H,179,225)(H,180,226)(H,181,223)(H,182,231)(H,183,232)(H,184,237)(H,185,233)(H,186,235)(H,187,238)(H,188,203)(H,189,227)(H,190,230)(H,191,228)(H,192,229)(H,204,205)(H,206,207)(H,208,209)(H,210,211)(H4,157,158,160)/t77-,78-,79-,80-,81-,82+,83+,91-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,119-,120-,121-,122-,123-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description
Agonist activity at GLP1R in rat INS-1 cells assessed as increase in glucose-stimulated insulin secretion after 1 hr by HTRF assay |
Eur J Med Chem 127: 703-714 (2017)
Article DOI: 10.1016/j.ejmech.2016.10.044
BindingDB Entry DOI: 10.7270/Q2T155W1 |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Rattus norvegicus) | BDBM50231943
(CHEMBL4093072)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(N)=O |r| Show InChI InChI=1S/C150H231N41O48S/c1-15-77(10)121(147(237)177-96(43-49-118(210)211)135(225)182-103(60-83-64-161-87-34-23-22-33-85(83)87)140(230)179-98(55-73(2)3)137(227)169-89(36-25-27-52-152)130(220)183-104(62-109(155)197)127(217)164-67-111(199)162-66-110(156)198)190-142(232)101(58-81-29-18-16-19-30-81)181-138(228)99(56-74(4)5)178-131(221)90(37-28-53-160-150(157)158)176-146(236)120(76(8)9)189-124(214)78(11)167-128(218)93(40-46-115(204)205)172-133(223)94(41-47-116(206)207)173-134(224)95(42-48-117(208)209)174-136(226)97(50-54-240-14)175-132(222)92(38-44-108(154)196)171-129(219)88(35-24-26-51-151)170-144(234)106(70-192)186-139(229)100(57-75(6)7)180-141(231)105(63-119(212)213)184-145(235)107(71-193)187-149(239)123(80(13)195)191-143(233)102(59-82-31-20-17-21-32-82)185-148(238)122(79(12)194)188-113(201)69-165-126(216)91(39-45-114(202)203)168-112(200)68-163-125(215)86(153)61-84-65-159-72-166-84/h16-23,29-34,64-65,72-80,86,88-107,120-123,161,192-195H,15,24-28,35-63,66-71,151-153H2,1-14H3,(H2,154,196)(H2,155,197)(H2,156,198)(H,159,166)(H,162,199)(H,163,215)(H,164,217)(H,165,216)(H,167,218)(H,168,200)(H,169,227)(H,170,234)(H,171,219)(H,172,223)(H,173,224)(H,174,226)(H,175,222)(H,176,236)(H,177,237)(H,178,221)(H,179,230)(H,180,231)(H,181,228)(H,182,225)(H,183,220)(H,184,235)(H,185,238)(H,186,229)(H,187,239)(H,188,201)(H,189,214)(H,190,232)(H,191,233)(H,202,203)(H,204,205)(H,206,207)(H,208,209)(H,210,211)(H,212,213)(H4,157,158,160)/t77-,78-,79+,80+,86-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,120-,121-,122-,123-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description
Agonist activity at GLP1R in rat INS-1 cells assessed as increase in glucose-stimulated insulin secretion after 1 hr by HTRF assay |
Eur J Med Chem 127: 703-714 (2017)
Article DOI: 10.1016/j.ejmech.2016.10.044
BindingDB Entry DOI: 10.7270/Q2T155W1 |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Rattus norvegicus) | BDBM50231901
(CHEMBL4088708)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O |r| Show InChI InChI=1S/C157H233N41O46/c1-17-81(10)127(154(242)176-85(14)133(221)184-112(65-92-68-167-98-36-25-24-35-96(92)98)145(233)186-107(60-78(4)5)146(234)195-125(79(6)7)152(240)183-100(37-26-28-56-158)136(224)169-71-118(207)177-99(39-30-58-166-157(163)164)135(223)168-70-117(162)206)197-147(235)110(61-88-31-20-18-21-32-88)187-141(229)105(51-55-123(214)215)182-140(228)101(38-27-29-57-159)179-131(219)83(12)173-130(218)82(11)175-139(227)104(48-52-116(161)205)178-119(208)72-170-138(226)103(50-54-122(212)213)181-142(230)106(59-77(2)3)185-143(231)108(63-90-40-44-94(203)45-41-90)188-150(238)114(74-199)192-144(232)109(64-91-42-46-95(204)47-43-91)190-153(241)126(80(8)9)196-149(237)113(67-124(216)217)189-151(239)115(75-200)193-156(244)129(87(16)202)198-148(236)111(62-89-33-22-19-23-34-89)191-155(243)128(86(15)201)194-120(209)73-171-137(225)102(49-53-121(210)211)180-132(220)84(13)174-134(222)97(160)66-93-69-165-76-172-93/h18-25,31-36,40-47,68-69,76-87,97,99-115,125-129,167,199-204H,17,26-30,37-39,48-67,70-75,158-160H2,1-16H3,(H2,161,205)(H2,162,206)(H,165,172)(H,168,223)(H,169,224)(H,170,226)(H,171,225)(H,173,218)(H,174,222)(H,175,227)(H,176,242)(H,177,207)(H,178,208)(H,179,219)(H,180,220)(H,181,230)(H,182,228)(H,183,240)(H,184,221)(H,185,231)(H,186,233)(H,187,229)(H,188,238)(H,189,239)(H,190,241)(H,191,243)(H,192,232)(H,193,244)(H,194,209)(H,195,234)(H,196,237)(H,197,235)(H,198,236)(H,210,211)(H,212,213)(H,214,215)(H,216,217)(H4,163,164,166)/t81-,82-,83-,84-,85-,86+,87+,97-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,125-,126-,127-,128-,129-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 16 | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description
Agonist activity at GLP1R in rat INS-1 cells assessed as increase in glucose-stimulated insulin secretion after 1 hr by HTRF assay |
Eur J Med Chem 127: 703-714 (2017)
Article DOI: 10.1016/j.ejmech.2016.10.044
BindingDB Entry DOI: 10.7270/Q2T155W1 |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Rattus norvegicus) | BDBM50231886
(CHEMBL4070761)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O |r| Show InChI InChI=1S/C155H234N42O45/c1-17-80(10)125(152(240)175-84(14)131(219)184-109(64-90-68-166-95-38-25-24-37-93(90)95)143(231)186-105(60-77(4)5)145(233)194-123(78(6)7)150(238)182-97(39-26-29-55-156)134(222)168-71-116(205)176-96(42-32-58-165-155(161)162)133(221)167-70-114(160)203)196-146(234)107(61-87-33-20-18-21-34-87)187-140(228)103(50-54-121(212)213)181-138(226)98(40-27-30-56-157)178-129(217)82(12)172-128(216)81(11)174-137(225)102(47-51-113(159)202)177-117(206)72-169-136(224)101(49-53-120(210)211)180-141(229)104(59-76(2)3)185-142(230)106(63-89-43-45-92(201)46-44-89)188-144(232)110-66-115(204)164-57-31-28-41-99(139(227)190-111(67-122(214)215)148(236)195-124(79(8)9)151(239)192-112(74-198)149(237)189-110)183-154(242)127(86(16)200)197-147(235)108(62-88-35-22-19-23-36-88)191-153(241)126(85(15)199)193-118(207)73-170-135(223)100(48-52-119(208)209)179-130(218)83(13)173-132(220)94(158)65-91-69-163-75-171-91/h18-25,33-38,43-46,68-69,75-86,94,96-112,123-127,166,198-201H,17,26-32,39-42,47-67,70-74,156-158H2,1-16H3,(H2,159,202)(H2,160,203)(H,163,171)(H,164,204)(H,167,221)(H,168,222)(H,169,224)(H,170,223)(H,172,216)(H,173,220)(H,174,225)(H,175,240)(H,176,205)(H,177,206)(H,178,217)(H,179,218)(H,180,229)(H,181,226)(H,182,238)(H,183,242)(H,184,219)(H,185,230)(H,186,231)(H,187,228)(H,188,232)(H,189,237)(H,190,227)(H,191,241)(H,192,239)(H,193,207)(H,194,233)(H,195,236)(H,196,234)(H,197,235)(H,208,209)(H,210,211)(H,212,213)(H,214,215)(H4,161,162,165)/t80-,81-,82-,83-,84-,85+,86+,94-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,123-,124-,125-,126-,127-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 50 | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description
Agonist activity at GLP1R in rat INS-1 cells assessed as increase in glucose-stimulated insulin secretion after 1 hr by HTRF assay |
Eur J Med Chem 127: 703-714 (2017)
Article DOI: 10.1016/j.ejmech.2016.10.044
BindingDB Entry DOI: 10.7270/Q2T155W1 |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Rattus norvegicus) | BDBM50393574
(CHEMBL2158422)Show SMILES COc1cc(ccc1OC(=O)c1cccs1)[C@H]1[C@@](NC(=O)c2ccc(NC(C)=O)cc2)([C@@H](c2ccc(OC(=O)c3cccs3)c(OC)c2)[C@]1(NC(=O)c1ccc(NC(C)=O)cc1)C(O)=O)C(O)=O |r,wU:16.17,48.54,31.34,17.19,wD:48.68,17.71,(32.36,-35.86,;31.04,-36.65,;29.69,-35.9,;28.37,-36.69,;27.03,-35.94,;27,-34.41,;28.31,-33.61,;29.67,-34.36,;30.98,-33.57,;30.96,-32.03,;29.61,-31.28,;32.2,-31.12,;33.67,-31.6,;34.58,-30.35,;33.67,-29.11,;32.21,-29.58,;25.71,-36.73,;25.71,-38.28,;26.78,-39.39,;26.77,-40.93,;25.43,-41.69,;28.1,-41.71,;28.08,-43.25,;29.4,-44.03,;30.75,-43.27,;32.07,-44.05,;32.06,-45.59,;30.72,-46.35,;33.39,-46.36,;30.75,-41.72,;29.43,-40.94,;24.17,-38.27,;23.38,-39.57,;24.1,-40.92,;23.31,-42.24,;21.77,-42.21,;20.97,-43.52,;21.71,-44.88,;23.24,-44.91,;20.76,-46.09,;19.21,-46.05,;18.69,-47.5,;19.91,-48.44,;21.18,-47.58,;21.03,-40.85,;19.49,-40.82,;18.75,-39.46,;21.83,-39.54,;24.17,-36.74,;23.4,-35.4,;24.17,-34.07,;25.71,-34.07,;23.4,-32.74,;24.17,-31.41,;23.4,-30.08,;21.86,-30.08,;21.09,-28.74,;21.86,-27.41,;23.4,-27.41,;21.08,-26.08,;21.09,-31.42,;21.87,-32.75,;22.63,-36.74,;21.86,-35.4,;21.86,-38.07,;27.25,-38.27,;28.02,-39.61,;27.77,-37.21,)| Show InChI InChI=1S/C48H40N4O14S2/c1-25(53)49-31-15-9-27(10-16-31)41(55)51-47(45(59)60)39(29-13-19-33(35(23-29)63-3)65-43(57)37-7-5-21-67-37)48(46(61)62,52-42(56)28-11-17-32(18-12-28)50-26(2)54)40(47)30-14-20-34(36(24-30)64-4)66-44(58)38-8-6-22-68-38/h5-24,39-40H,1-4H3,(H,49,53)(H,50,54)(H,51,55)(H,52,56)(H,59,60)(H,61,62)/t39-,40+,47+,48- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 118 | n/a | n/a | n/a | n/a |
The National Center for Drug Screening
Curated by ChEMBL
| Assay Description
Agonist activity at rat GLP1R expressed in HEK293 cells assessed as stimulation of cAMP levels incubated for 6 hrs by multiple response element/cAMP ... |
J Med Chem 55: 250-67 (2012)
Article DOI: 10.1021/jm201150j
BindingDB Entry DOI: 10.7270/Q2M046JC |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Rattus norvegicus) | BDBM50231963
(CHEMBL4104146)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O)C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O |r| Show InChI InChI=1S/C152H227N41O45/c1-16-78(10)122(148(235)176-95-38-26-28-52-160-113(202)62-104(131(218)165-67-114(203)171-93(39-29-53-161-152(157)158)129(216)163-66-112(156)201)183-146(233)120(76(6)7)189-138(225)99(55-74(2)3)177-137(224)103(180-134(95)221)60-87-64-162-92-36-24-23-35-90(87)92)191-139(226)101(57-84-31-19-17-20-32-84)178-135(222)98(47-50-118(208)209)175-133(220)94(37-25-27-51-153)173-126(213)80(12)168-125(212)79(11)170-132(219)97(45-48-111(155)200)172-115(204)68-166-145(232)110-40-30-54-193(110)151(238)106(56-75(4)5)184-136(223)100(59-86-41-43-89(199)44-42-86)179-142(229)107(70-194)185-144(231)109(72-196)186-147(234)121(77(8)9)190-141(228)105(63-119(210)211)181-143(230)108(71-195)187-150(237)124(83(15)198)192-140(227)102(58-85-33-21-18-22-34-85)182-149(236)123(82(14)197)188-116(205)69-164-130(217)96(46-49-117(206)207)174-127(214)81(13)169-128(215)91(154)61-88-65-159-73-167-88/h17-24,31-36,41-44,64-65,73-83,91,93-110,120-124,162,194-199H,16,25-30,37-40,45-63,66-72,153-154H2,1-15H3,(H2,155,200)(H2,156,201)(H,159,167)(H,160,202)(H,163,216)(H,164,217)(H,165,218)(H,166,232)(H,168,212)(H,169,215)(H,170,219)(H,171,203)(H,172,204)(H,173,213)(H,174,214)(H,175,220)(H,176,235)(H,177,224)(H,178,222)(H,179,229)(H,180,221)(H,181,230)(H,182,236)(H,183,233)(H,184,223)(H,185,231)(H,186,234)(H,187,237)(H,188,205)(H,189,225)(H,190,228)(H,191,226)(H,192,227)(H,206,207)(H,208,209)(H,210,211)(H4,157,158,161)/t78-,79-,80-,81-,82+,83+,91-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,120-,121-,122-,123-,124-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 130 | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description
Agonist activity at GLP1R in rat INS-1 cells assessed as increase in glucose-stimulated insulin secretion after 1 hr by HTRF assay |
Eur J Med Chem 127: 703-714 (2017)
Article DOI: 10.1016/j.ejmech.2016.10.044
BindingDB Entry DOI: 10.7270/Q2T155W1 |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Rattus norvegicus) | BDBM50393576
(CHEMBL2158419)Show SMILES COc1cc(ccc1OC(=O)c1cccs1)[C@H]1[C@@](NC(=O)c2ccc(NC(=O)C3CC3)cc2)([C@@H](c2ccc(OC(=O)c3cccs3)c(OC)c2)[C@]1(NC(=O)c1ccc(NC(=O)C2CC2)cc1)C(O)=O)C(O)=O |r,wU:50.57,33.37,17.19,16.17,wD:50.74,17.77,(10.64,-5.72,;9.32,-6.51,;7.97,-5.76,;6.66,-6.55,;5.32,-5.8,;5.28,-4.27,;6.59,-3.47,;7.95,-4.22,;9.27,-3.43,;9.24,-1.89,;7.89,-1.14,;10.49,-.98,;11.95,-1.46,;12.86,-.22,;11.96,1.03,;10.49,.56,;4,-6.6,;4,-8.14,;5.07,-9.25,;5.05,-10.79,;3.71,-11.55,;6.38,-11.57,;6.36,-13.11,;7.69,-13.89,;9.03,-13.13,;10.36,-13.91,;10.35,-15.45,;11.68,-16.22,;9.01,-16.21,;7.47,-16.2,;8.23,-17.54,;9.04,-11.58,;7.71,-10.81,;2.46,-8.14,;1.66,-9.43,;2.39,-10.78,;1.6,-12.1,;.05,-12.07,;-.75,-13.39,;-.01,-14.74,;1.53,-14.77,;-.95,-15.95,;-2.5,-15.91,;-3.02,-17.36,;-1.81,-18.3,;-.53,-17.44,;-.69,-10.72,;-2.22,-10.68,;-2.96,-9.32,;.12,-9.4,;2.45,-6.6,;1.68,-5.26,;2.45,-3.93,;3.99,-3.93,;1.68,-2.6,;2.46,-1.27,;1.69,.06,;.15,.06,;-.63,1.4,;.14,2.73,;-.63,4.06,;1.68,2.73,;3.01,1.96,;3.01,3.5,;-.62,-1.28,;.15,-2.61,;.91,-6.6,;.14,-5.27,;.14,-7.93,;5.53,-8.14,;6.3,-9.47,;6.05,-7.07,)| Show InChI InChI=1S/C52H44N4O14S2/c1-67-37-25-31(15-21-35(37)69-47(61)39-5-3-23-71-39)41-51(49(63)64,55-45(59)29-11-17-33(18-12-29)53-43(57)27-7-8-27)42(32-16-22-36(38(26-32)68-2)70-48(62)40-6-4-24-72-40)52(41,50(65)66)56-46(60)30-13-19-34(20-14-30)54-44(58)28-9-10-28/h3-6,11-28,41-42H,7-10H2,1-2H3,(H,53,57)(H,54,58)(H,55,59)(H,56,60)(H,63,64)(H,65,66)/t41-,42+,51+,52- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 148 | n/a | n/a | n/a | n/a |
The National Center for Drug Screening
Curated by ChEMBL
| Assay Description
Agonist activity at rat GLP1R expressed in HEK293 cells assessed as stimulation of cAMP levels incubated for 6 hrs by multiple response element/cAMP ... |
J Med Chem 55: 250-67 (2012)
Article DOI: 10.1021/jm201150j
BindingDB Entry DOI: 10.7270/Q2M046JC |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Rattus norvegicus) | BDBM50393572
(CHEMBL2158488)Show SMILES COc1cc(ccc1OC(=O)c1cccs1)[C@H]1[C@@](NC(=O)c2ccc(NC(=O)C(C)C)cc2)([C@@H](c2ccc(OC(=O)c3cccs3)c(OC)c2)[C@]1(NC(=O)c1ccc(NC(=O)C(C)C)cc1)C(O)=O)C(O)=O |r,wU:50.56,33.36,17.19,16.17,wD:50.72,17.75,(9.02,-36.38,;7.7,-37.17,;6.36,-36.42,;5.04,-37.21,;3.7,-36.46,;3.66,-34.93,;4.98,-34.13,;6.33,-34.88,;7.65,-34.09,;7.62,-32.55,;6.28,-31.8,;8.87,-31.64,;10.34,-32.12,;11.24,-30.88,;10.34,-29.63,;8.87,-30.1,;2.38,-37.26,;2.38,-38.8,;3.45,-39.91,;3.44,-41.45,;2.1,-42.21,;4.76,-42.23,;4.74,-43.77,;6.07,-44.55,;7.41,-43.79,;8.74,-44.57,;8.73,-46.11,;10.06,-46.88,;7.39,-46.87,;6.06,-46.09,;7.38,-48.41,;7.42,-42.24,;6.09,-41.47,;.84,-38.8,;.05,-40.09,;.77,-41.44,;-.02,-42.76,;-1.57,-42.73,;-2.37,-44.05,;-1.63,-45.4,;-.09,-45.43,;-2.57,-46.61,;-4.12,-46.57,;-4.64,-48.02,;-3.42,-48.96,;-2.15,-48.1,;-2.3,-41.38,;-3.84,-41.34,;-4.58,-39.98,;-1.5,-40.06,;.84,-37.26,;.07,-35.92,;.84,-34.59,;2.38,-34.59,;.07,-33.26,;.84,-31.93,;.07,-30.6,;-1.47,-30.6,;-2.24,-29.26,;-1.48,-27.93,;-2.25,-26.6,;.06,-27.93,;.83,-26.59,;.84,-29.26,;-2.24,-31.94,;-1.47,-33.27,;-.71,-37.26,;-1.48,-35.93,;-1.48,-38.59,;3.91,-38.8,;4.68,-40.13,;4.43,-37.73,)| Show InChI InChI=1S/C52H48N4O14S2/c1-27(2)43(57)53-33-17-11-29(12-18-33)45(59)55-51(49(63)64)41(31-15-21-35(37(25-31)67-5)69-47(61)39-9-7-23-71-39)52(50(65)66,56-46(60)30-13-19-34(20-14-30)54-44(58)28(3)4)42(51)32-16-22-36(38(26-32)68-6)70-48(62)40-10-8-24-72-40/h7-28,41-42H,1-6H3,(H,53,57)(H,54,58)(H,55,59)(H,56,60)(H,63,64)(H,65,66)/t41-,42+,51+,52- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | n/a | n/a | 203 | n/a | n/a | n/a | n/a |
The National Center for Drug Screening
Curated by ChEMBL
| Assay Description
Agonist activity at rat GLP1R expressed in HEK293 cells assessed as stimulation of cAMP levels incubated for 6 hrs by multiple response element/cAMP ... |
J Med Chem 55: 250-67 (2012)
Article DOI: 10.1021/jm201150j
BindingDB Entry DOI: 10.7270/Q2M046JC |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Glucagon-like peptide 1 receptor
(Rattus norvegicus) | BDBM50393590
(CHEMBL2158404)Show SMILES CCOc1cc(ccc1OC(=O)c1cccs1)[C@H]1[C@@](NC(=O)c2ccc(NC(=O)OC(C)(C)C)cc2)([C@@H](c2ccc(OC(=O)c3cccs3)c(OCC)c2)[C@]1(NC(=O)c1ccc(NC(=O)OC(C)(C)C)cc1)C(O)=O)C(O)=O |r,wU:36.39,18.20,17.18,54.60,wD:18.81,54.78,(25.6,-43.26,;24.85,-41.91,;25.65,-40.59,;24.9,-39.25,;25.69,-37.93,;24.97,-36.58,;23.42,-36.55,;22.62,-37.86,;23.35,-39.21,;22.55,-40.53,;21.01,-40.49,;20.21,-41.81,;20.16,-39.21,;18.62,-39.15,;18.2,-37.67,;19.48,-36.81,;20.69,-37.76,;25.76,-35.28,;25.76,-33.74,;24.99,-32.41,;25.76,-31.07,;27.3,-31.07,;24.99,-29.74,;25.76,-28.41,;24.99,-27.08,;23.45,-27.08,;22.68,-25.75,;23.44,-24.41,;22.67,-23.08,;24.98,-24.41,;25.75,-23.08,;27.29,-23.07,;24.98,-21.74,;26.51,-21.73,;22.68,-28.42,;23.45,-29.75,;27.3,-33.74,;28.62,-32.95,;29.96,-33.7,;31.28,-32.91,;31.25,-31.37,;32.57,-30.57,;33.92,-31.32,;35.24,-30.52,;33.95,-32.86,;32.72,-33.79,;33.22,-35.24,;34.76,-35.22,;35.21,-33.74,;29.9,-30.62,;29.86,-29.08,;31.18,-28.28,;31.15,-26.74,;28.58,-31.41,;27.3,-35.28,;28.37,-36.39,;28.36,-37.93,;27.02,-38.69,;29.68,-38.71,;29.66,-40.25,;30.99,-41.03,;32.33,-40.27,;33.66,-41.05,;33.65,-42.59,;34.98,-43.37,;32.31,-43.35,;32.3,-44.89,;30.96,-45.65,;33.63,-45.67,;32.31,-46.43,;32.34,-38.72,;31.01,-37.95,;28.83,-35.28,;29.6,-36.61,;29.35,-34.22,;24.21,-33.74,;23.44,-32.41,;23.44,-35.08,)| Show InChI InChI=1S/C56H56N4O16S2/c1-9-71-39-29-33(19-25-37(39)73-47(63)41-13-11-27-77-41)43-55(49(65)66,59-45(61)31-15-21-35(22-16-31)57-51(69)75-53(3,4)5)44(34-20-26-38(40(30-34)72-10-2)74-48(64)42-14-12-28-78-42)56(43,50(67)68)60-46(62)32-17-23-36(24-18-32)58-52(70)76-54(6,7)8/h11-30,43-44H,9-10H2,1-8H3,(H,57,69)(H,58,70)(H,59,61)(H,60,62)(H,65,66)(H,67,68)/t43-,44+,55+,56- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 326 | n/a | n/a | n/a | n/a |
The National Center for Drug Screening
Curated by ChEMBL
| Assay Description
Agonist activity at rat GLP1R expressed in HEK293 cells assessed as stimulation of cAMP levels incubated for 6 hrs by multiple response element/cAMP ... |
J Med Chem 55: 250-67 (2012)
Article DOI: 10.1021/jm201150j
BindingDB Entry DOI: 10.7270/Q2M046JC |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Rattus norvegicus) | BDBM50260246
(1,3-bis(4-(tert-butoxycarbonyl)benzamido)-2,4-bis(...)Show SMILES COc1cc(ccc1OC(=O)c1cccs1)C1C(NC(=O)c2ccc(NC(=O)OC(C)(C)C)cc2)(C(c2ccc(OC(=O)c3cccs3)c(OC)c2)C1(NC(=O)c1ccc(NC(=O)OC(C)(C)C)cc1)C(O)=O)C(O)=O |(.32,-12.51,;1.08,-13.85,;2.62,-13.86,;3.39,-12.53,;4.93,-12.54,;5.69,-13.87,;4.93,-15.19,;3.38,-15.19,;2.61,-16.52,;1.07,-16.52,;.3,-15.18,;.3,-17.85,;-1.23,-18.01,;-1.55,-19.51,;-.22,-20.29,;.93,-19.26,;4.93,-10.99,;4.93,-9.45,;4.92,-7.9,;3.56,-7.14,;2.02,-7.16,;3.56,-5.61,;4.89,-4.84,;4.89,-3.3,;3.55,-2.53,;3.55,-.99,;4.88,-.21,;6.22,-.98,;4.87,1.33,;6.21,2.1,;7.53,2.89,;6.99,.77,;5.43,3.43,;2.22,-3.31,;2.23,-4.85,;6.47,-9.45,;6.46,-7.9,;5.7,-6.57,;6.46,-5.25,;8,-5.24,;8.77,-3.91,;10.31,-3.9,;11.08,-5.24,;11.07,-2.57,;12.6,-2.4,;12.92,-.9,;11.58,-.13,;10.44,-1.16,;8.77,-6.57,;10.31,-6.57,;11.08,-7.91,;8,-7.9,;6.47,-10.99,;6.48,-12.53,;7.83,-13.3,;9.37,-13.29,;7.82,-14.84,;6.48,-15.6,;6.47,-17.14,;7.8,-17.92,;7.8,-19.46,;6.46,-20.22,;5.13,-19.45,;6.45,-21.76,;5.12,-22.53,;3.77,-23.29,;5.88,-23.87,;4.36,-21.19,;9.14,-17.14,;9.15,-15.61,;8.02,-11.01,;8.77,-12.35,;8.8,-9.68,;3.39,-9.44,;2.62,-8.1,;2.61,-10.77,)| Show InChI InChI=1S/C54H52N4O16S2/c1-51(2,3)73-49(67)55-33-19-13-29(14-20-33)43(59)57-53(47(63)64)41(31-17-23-35(37(27-31)69-7)71-45(61)39-11-9-25-75-39)54(48(65)66,58-44(60)30-15-21-34(22-16-30)56-50(68)74-52(4,5)6)42(53)32-18-24-36(38(28-32)70-8)72-46(62)40-12-10-26-76-40/h9-28,41-42H,1-8H3,(H,55,67)(H,56,68)(H,57,59)(H,58,60)(H,63,64)(H,65,66) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PDB
Article
PubMed
| n/a | n/a | n/a | n/a | 370 | n/a | n/a | n/a | n/a |
The National Center for Drug Screening
Curated by ChEMBL
| Assay Description
Agonist activity at rat GLP1R expressed in HEK293 cells assessed as stimulation of cAMP levels incubated for 6 hrs by multiple response element/cAMP ... |
J Med Chem 55: 250-67 (2012)
Article DOI: 10.1021/jm201150j
BindingDB Entry DOI: 10.7270/Q2M046JC |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Glucagon-like peptide 1 receptor
(Rattus norvegicus) | BDBM50260246
(1,3-bis(4-(tert-butoxycarbonyl)benzamido)-2,4-bis(...)Show SMILES COc1cc(ccc1OC(=O)c1cccs1)C1C(NC(=O)c2ccc(NC(=O)OC(C)(C)C)cc2)(C(c2ccc(OC(=O)c3cccs3)c(OC)c2)C1(NC(=O)c1ccc(NC(=O)OC(C)(C)C)cc1)C(O)=O)C(O)=O |(.32,-12.51,;1.08,-13.85,;2.62,-13.86,;3.39,-12.53,;4.93,-12.54,;5.69,-13.87,;4.93,-15.19,;3.38,-15.19,;2.61,-16.52,;1.07,-16.52,;.3,-15.18,;.3,-17.85,;-1.23,-18.01,;-1.55,-19.51,;-.22,-20.29,;.93,-19.26,;4.93,-10.99,;4.93,-9.45,;4.92,-7.9,;3.56,-7.14,;2.02,-7.16,;3.56,-5.61,;4.89,-4.84,;4.89,-3.3,;3.55,-2.53,;3.55,-.99,;4.88,-.21,;6.22,-.98,;4.87,1.33,;6.21,2.1,;7.53,2.89,;6.99,.77,;5.43,3.43,;2.22,-3.31,;2.23,-4.85,;6.47,-9.45,;6.46,-7.9,;5.7,-6.57,;6.46,-5.25,;8,-5.24,;8.77,-3.91,;10.31,-3.9,;11.08,-5.24,;11.07,-2.57,;12.6,-2.4,;12.92,-.9,;11.58,-.13,;10.44,-1.16,;8.77,-6.57,;10.31,-6.57,;11.08,-7.91,;8,-7.9,;6.47,-10.99,;6.48,-12.53,;7.83,-13.3,;9.37,-13.29,;7.82,-14.84,;6.48,-15.6,;6.47,-17.14,;7.8,-17.92,;7.8,-19.46,;6.46,-20.22,;5.13,-19.45,;6.45,-21.76,;5.12,-22.53,;3.77,-23.29,;5.88,-23.87,;4.36,-21.19,;9.14,-17.14,;9.15,-15.61,;8.02,-11.01,;8.77,-12.35,;8.8,-9.68,;3.39,-9.44,;2.62,-8.1,;2.61,-10.77,)| Show InChI InChI=1S/C54H52N4O16S2/c1-51(2,3)73-49(67)55-33-19-13-29(14-20-33)43(59)57-53(47(63)64)41(31-17-23-35(37(27-31)69-7)71-45(61)39-11-9-25-75-39)54(48(65)66,58-44(60)30-15-21-34(22-16-30)56-50(68)74-52(4,5)6)42(53)32-18-24-36(38(28-32)70-8)72-46(62)40-12-10-26-76-40/h9-28,41-42H,1-8H3,(H,55,67)(H,56,68)(H,57,59)(H,58,60)(H,63,64)(H,65,66) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PDB
Article
PubMed
| n/a | n/a | n/a | n/a | 371 | n/a | n/a | n/a | n/a |
The National Center for Drug Screening
Curated by ChEMBL
| Assay Description
Agonist activity at rat GLP1R expressed in HEK293 cells assessed as stimulation of cAMP levels incubated for 6 hrs by multiple response element/cAMP ... |
J Med Chem 55: 250-67 (2012)
Article DOI: 10.1021/jm201150j
BindingDB Entry DOI: 10.7270/Q2M046JC |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Glucagon-like peptide 1 receptor
(Rattus norvegicus) | BDBM50260245
(1,3-bis(4-(cyclopentanecarboxamido)benzamido)-2,4-...)Show SMILES COc1cc(ccc1OC(=O)c1cccs1)C1C(NC(=O)c2ccc(NC(=O)C3CCCC3)cc2)(C(c2ccc(OC(=O)c3cccs3)c(OC)c2)C1(NC(=O)c1ccc(NC(=O)C2CCCC2)cc1)C(O)=O)C(O)=O |(19.44,-26.93,;20.21,-28.27,;21.75,-28.28,;22.52,-26.96,;24.06,-26.97,;24.82,-28.29,;24.05,-29.61,;22.51,-29.61,;21.73,-30.95,;20.19,-30.94,;19.42,-29.6,;19.42,-32.27,;17.89,-32.43,;17.57,-33.94,;18.9,-34.71,;20.05,-33.68,;24.06,-25.41,;25.6,-25.41,;25.61,-26.96,;26.95,-27.73,;28.49,-27.71,;26.94,-29.26,;25.61,-30.03,;25.6,-31.57,;26.92,-32.34,;26.92,-33.88,;25.59,-34.65,;24.26,-33.87,;25.58,-36.19,;24.34,-37.09,;24.8,-38.56,;26.34,-38.56,;26.82,-37.1,;28.27,-31.57,;28.27,-30.04,;25.6,-23.87,;25.59,-22.31,;24.82,-21,;25.59,-19.67,;27.13,-19.66,;27.89,-18.33,;29.43,-18.32,;30.21,-19.66,;30.2,-16.99,;31.73,-16.82,;32.05,-15.32,;30.71,-14.54,;29.56,-15.58,;27.89,-20.99,;29.43,-20.99,;30.21,-22.32,;27.13,-22.32,;24.06,-23.86,;24.04,-22.32,;22.69,-21.56,;21.15,-21.58,;22.69,-20.03,;24.01,-19.25,;24.01,-17.71,;22.68,-16.95,;22.68,-15.41,;24,-14.63,;25.34,-15.4,;24,-13.09,;25.24,-12.18,;24.76,-10.71,;23.22,-10.72,;22.75,-12.19,;21.34,-17.72,;21.35,-19.26,;22.52,-23.86,;21.75,-22.53,;21.74,-25.19,;27.15,-25.43,;27.9,-26.77,;27.93,-24.1,)| Show InChI InChI=1S/C56H52N4O14S2/c1-71-41-29-35(19-25-39(41)73-51(65)43-13-7-27-75-43)45-55(53(67)68,59-49(63)33-15-21-37(22-16-33)57-47(61)31-9-3-4-10-31)46(36-20-26-40(42(30-36)72-2)74-52(66)44-14-8-28-76-44)56(45,54(69)70)60-50(64)34-17-23-38(24-18-34)58-48(62)32-11-5-6-12-32/h7-8,13-32,45-46H,3-6,9-12H2,1-2H3,(H,57,61)(H,58,62)(H,59,63)(H,60,64)(H,67,68)(H,69,70) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 657 | n/a | n/a | n/a | n/a |
The National Center for Drug Screening
Curated by ChEMBL
| Assay Description
Agonist activity at rat GLP1R expressed in HEK293 cells assessed as stimulation of cAMP levels incubated for 6 hrs by multiple response element/cAMP ... |
J Med Chem 55: 250-67 (2012)
Article DOI: 10.1021/jm201150j
BindingDB Entry DOI: 10.7270/Q2M046JC |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Rattus norvegicus) | BDBM50393573
(CHEMBL2158423)Show SMILES CCC(=O)Nc1ccc(cc1)C(=O)N[C@@]1([C@H](c2ccc(OC(=O)c3cccs3)c(OC)c2)[C@](NC(=O)c2ccc(NC(=O)CC)cc2)([C@@H]1c1ccc(OC(=O)c2cccs2)c(OC)c1)C(O)=O)C(O)=O |r,wU:15.16,32.35,47.52,14.14,wD:32.70,14.73,(9.59,-16.65,;9.6,-15.11,;10.94,-14.35,;12.27,-15.13,;10.95,-12.81,;9.62,-12.03,;8.28,-12.79,;6.95,-12.01,;6.97,-10.47,;8.3,-9.71,;9.63,-10.48,;5.64,-9.69,;4.31,-10.45,;5.66,-8.15,;4.59,-7.04,;4.59,-5.5,;5.91,-4.71,;5.87,-3.17,;7.18,-2.38,;8.54,-3.12,;9.86,-2.33,;9.83,-.79,;8.48,-.05,;11.08,.11,;12.54,-.36,;13.45,.88,;12.55,2.13,;11.08,1.65,;8.57,-4.67,;9.91,-5.41,;11.23,-4.62,;7.25,-5.46,;3.04,-5.5,;2.28,-4.17,;3.05,-2.83,;4.59,-2.83,;2.27,-1.5,;3.05,-.17,;2.28,1.16,;.74,1.16,;-.04,2.49,;.73,3.83,;-.04,5.16,;2.27,3.83,;3.04,2.5,;-.03,-.18,;.74,-1.51,;3.05,-7.04,;2.25,-8.34,;2.98,-9.68,;2.19,-11.01,;.64,-10.97,;-.16,-12.29,;.58,-13.64,;2.12,-13.68,;-.36,-14.86,;-1.91,-14.81,;-2.43,-16.26,;-1.21,-17.21,;.06,-16.34,;-.09,-9.62,;-1.63,-9.58,;-2.37,-8.23,;.71,-8.31,;1.5,-5.5,;.73,-4.17,;.73,-6.84,;6.12,-7.04,;6.89,-8.37,;6.64,-5.98,)| Show InChI InChI=1S/C50H44N4O14S2/c1-5-39(55)51-31-17-11-27(12-18-31)43(57)53-49(47(61)62)41(29-15-21-33(35(25-29)65-3)67-45(59)37-9-7-23-69-37)50(48(63)64,54-44(58)28-13-19-32(20-14-28)52-40(56)6-2)42(49)30-16-22-34(36(26-30)66-4)68-46(60)38-10-8-24-70-38/h7-26,41-42H,5-6H2,1-4H3,(H,51,55)(H,52,56)(H,53,57)(H,54,58)(H,61,62)(H,63,64)/t41-,42+,49+,50- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 696 | n/a | n/a | n/a | n/a |
The National Center for Drug Screening
Curated by ChEMBL
| Assay Description
Agonist activity at rat GLP1R expressed in HEK293 cells assessed as stimulation of cAMP levels incubated for 6 hrs by multiple response element/cAMP ... |
J Med Chem 55: 250-67 (2012)
Article DOI: 10.1021/jm201150j
BindingDB Entry DOI: 10.7270/Q2M046JC |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Rattus norvegicus) | BDBM50393575
(CHEMBL2158420)Show SMILES COc1cc(ccc1OC(=O)c1cccs1)[C@H]1[C@@](NC(=O)c2ccc(NC(=O)C3CCC3)cc2)([C@@H](c2ccc(OC(=O)c3cccs3)c(OC)c2)[C@]1(NC(=O)c1ccc(NC(=O)C2CCC2)cc1)C(O)=O)C(O)=O |r,wU:51.58,34.38,17.19,16.17,wD:51.76,17.79,(35.31,-5.19,;33.98,-5.98,;32.64,-5.23,;31.32,-6.03,;29.98,-5.28,;29.94,-3.74,;31.26,-2.95,;32.61,-3.69,;33.93,-2.9,;33.9,-1.36,;32.56,-.61,;35.15,-.46,;36.62,-.93,;37.52,.31,;36.62,1.56,;35.16,1.09,;28.66,-6.07,;28.66,-7.61,;29.73,-8.72,;29.72,-10.26,;28.38,-11.02,;31.04,-11.04,;31.03,-12.58,;32.35,-13.36,;33.69,-12.6,;35.02,-13.38,;35.01,-14.92,;36.34,-15.7,;33.68,-15.68,;32.2,-15.27,;31.79,-16.75,;33.27,-17.16,;33.7,-11.05,;32.37,-10.28,;27.12,-7.61,;26.33,-8.9,;27.05,-10.25,;26.26,-11.57,;24.71,-11.54,;23.91,-12.86,;24.65,-14.21,;26.19,-14.24,;23.71,-15.43,;22.16,-15.38,;21.64,-16.83,;22.86,-17.77,;24.13,-16.91,;23.98,-10.19,;22.44,-10.15,;21.7,-8.8,;24.78,-8.87,;27.12,-6.07,;26.35,-4.73,;27.12,-3.4,;28.66,-3.4,;26.35,-2.07,;27.12,-.74,;26.35,.59,;24.81,.59,;24.04,1.92,;24.8,3.26,;24.03,4.59,;26.35,3.26,;27.44,2.17,;28.52,3.26,;27.43,4.35,;24.04,-.75,;24.81,-2.08,;25.57,-6.07,;24.8,-4.74,;24.8,-7.4,;30.19,-7.61,;30.96,-8.94,;30.71,-6.54,)| Show InChI InChI=1S/C54H48N4O14S2/c1-69-39-27-33(17-23-37(39)71-49(63)41-11-5-25-73-41)43-53(51(65)66,57-47(61)31-13-19-35(20-14-31)55-45(59)29-7-3-8-29)44(34-18-24-38(40(28-34)70-2)72-50(64)42-12-6-26-74-42)54(43,52(67)68)58-48(62)32-15-21-36(22-16-32)56-46(60)30-9-4-10-30/h5-6,11-30,43-44H,3-4,7-10H2,1-2H3,(H,55,59)(H,56,60)(H,57,61)(H,58,62)(H,65,66)(H,67,68)/t43-,44+,53+,54- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 749 | n/a | n/a | n/a | n/a |
The National Center for Drug Screening
Curated by ChEMBL
| Assay Description
Agonist activity at rat GLP1R expressed in HEK293 cells assessed as stimulation of cAMP levels incubated for 6 hrs by multiple response element/cAMP ... |
J Med Chem 55: 250-67 (2012)
Article DOI: 10.1021/jm201150j
BindingDB Entry DOI: 10.7270/Q2M046JC |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Rattus norvegicus) | BDBM50260245
(1,3-bis(4-(cyclopentanecarboxamido)benzamido)-2,4-...)Show SMILES COc1cc(ccc1OC(=O)c1cccs1)C1C(NC(=O)c2ccc(NC(=O)C3CCCC3)cc2)(C(c2ccc(OC(=O)c3cccs3)c(OC)c2)C1(NC(=O)c1ccc(NC(=O)C2CCCC2)cc1)C(O)=O)C(O)=O |(19.44,-26.93,;20.21,-28.27,;21.75,-28.28,;22.52,-26.96,;24.06,-26.97,;24.82,-28.29,;24.05,-29.61,;22.51,-29.61,;21.73,-30.95,;20.19,-30.94,;19.42,-29.6,;19.42,-32.27,;17.89,-32.43,;17.57,-33.94,;18.9,-34.71,;20.05,-33.68,;24.06,-25.41,;25.6,-25.41,;25.61,-26.96,;26.95,-27.73,;28.49,-27.71,;26.94,-29.26,;25.61,-30.03,;25.6,-31.57,;26.92,-32.34,;26.92,-33.88,;25.59,-34.65,;24.26,-33.87,;25.58,-36.19,;24.34,-37.09,;24.8,-38.56,;26.34,-38.56,;26.82,-37.1,;28.27,-31.57,;28.27,-30.04,;25.6,-23.87,;25.59,-22.31,;24.82,-21,;25.59,-19.67,;27.13,-19.66,;27.89,-18.33,;29.43,-18.32,;30.21,-19.66,;30.2,-16.99,;31.73,-16.82,;32.05,-15.32,;30.71,-14.54,;29.56,-15.58,;27.89,-20.99,;29.43,-20.99,;30.21,-22.32,;27.13,-22.32,;24.06,-23.86,;24.04,-22.32,;22.69,-21.56,;21.15,-21.58,;22.69,-20.03,;24.01,-19.25,;24.01,-17.71,;22.68,-16.95,;22.68,-15.41,;24,-14.63,;25.34,-15.4,;24,-13.09,;25.24,-12.18,;24.76,-10.71,;23.22,-10.72,;22.75,-12.19,;21.34,-17.72,;21.35,-19.26,;22.52,-23.86,;21.75,-22.53,;21.74,-25.19,;27.15,-25.43,;27.9,-26.77,;27.93,-24.1,)| Show InChI InChI=1S/C56H52N4O14S2/c1-71-41-29-35(19-25-39(41)73-51(65)43-13-7-27-75-43)45-55(53(67)68,59-49(63)33-15-21-37(22-16-33)57-47(61)31-9-3-4-10-31)46(36-20-26-40(42(30-36)72-2)74-52(66)44-14-8-28-76-44)56(45,54(69)70)60-50(64)34-17-23-38(24-18-34)58-48(62)32-11-5-6-12-32/h7-8,13-32,45-46H,3-6,9-12H2,1-2H3,(H,57,61)(H,58,62)(H,59,63)(H,60,64)(H,67,68)(H,69,70) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.08E+3 | n/a | n/a | n/a | n/a |
National Center for Drug Screening
Curated by ChEMBL
| Assay Description
Agonist activity at rat GLP1 receptor expressed in HEK293 cells assessed as cAMP release |
Proc Natl Acad Sci U S A 104: 943-8 (2007)
Article DOI: 10.1073/pnas.0610173104
BindingDB Entry DOI: 10.7270/Q2TM79VV |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Rattus norvegicus) | BDBM50393571
(CHEMBL2158489)Show SMILES COc1cc(ccc1OC(=O)c1cccs1)[C@H]1[C@@](NC(=O)c2ccc(NC(=O)C(C)(C)C)cc2)([C@@H](c2ccc(OC(=O)c3cccs3)c(OC)c2)[C@]1(NC(=O)c1ccc(NC(=O)C(C)(C)C)cc1)C(O)=O)C(O)=O |r,wU:51.57,34.37,17.19,16.17,wD:51.74,17.77,(33.17,-34.99,;31.85,-35.78,;30.5,-35.03,;29.18,-35.82,;27.84,-35.07,;27.8,-33.54,;29.12,-32.74,;30.47,-33.49,;31.79,-32.7,;31.77,-31.16,;30.42,-30.41,;33.01,-30.25,;34.48,-30.73,;35.39,-29.48,;34.48,-28.24,;33.02,-28.71,;26.52,-35.86,;26.52,-37.4,;27.59,-38.52,;27.58,-40.06,;26.24,-40.82,;28.91,-40.84,;28.89,-42.37,;30.21,-43.15,;31.55,-42.4,;32.88,-43.17,;32.87,-44.71,;34.2,-45.49,;31.53,-45.48,;30.21,-44.7,;31.52,-47.02,;30.04,-45.87,;31.56,-40.85,;30.23,-40.07,;24.98,-37.4,;24.19,-38.7,;24.91,-40.05,;24.12,-41.37,;22.58,-41.34,;21.78,-42.65,;22.51,-44,;24.05,-44.04,;21.57,-45.22,;20.02,-45.18,;19.5,-46.63,;20.72,-47.57,;21.99,-46.7,;21.84,-39.98,;20.3,-39.94,;19.56,-38.59,;22.64,-38.67,;24.98,-35.87,;24.21,-34.53,;24.98,-33.2,;26.52,-33.2,;24.21,-31.86,;24.98,-30.54,;24.21,-29.2,;22.67,-29.2,;21.9,-27.87,;22.67,-26.54,;21.89,-25.2,;24.21,-26.53,;24.98,-27.87,;24.97,-25.2,;25.74,-26.53,;21.9,-30.55,;22.68,-31.87,;23.43,-35.87,;22.66,-34.53,;22.67,-37.2,;28.05,-37.4,;28.83,-38.74,;28.57,-36.34,)| Show InChI InChI=1S/C54H52N4O14S2/c1-51(2,3)47(63)55-33-19-13-29(14-20-33)43(59)57-53(49(65)66)41(31-17-23-35(37(27-31)69-7)71-45(61)39-11-9-25-73-39)54(50(67)68,58-44(60)30-15-21-34(22-16-30)56-48(64)52(4,5)6)42(53)32-18-24-36(38(28-32)70-8)72-46(62)40-12-10-26-74-40/h9-28,41-42H,1-8H3,(H,55,63)(H,56,64)(H,57,59)(H,58,60)(H,65,66)(H,67,68)/t41-,42+,53+,54- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.11E+3 | n/a | n/a | n/a | n/a |
The National Center for Drug Screening
Curated by ChEMBL
| Assay Description
Agonist activity at rat GLP1R expressed in HEK293 cells assessed as stimulation of cAMP levels incubated for 6 hrs by multiple response element/cAMP ... |
J Med Chem 55: 250-67 (2012)
Article DOI: 10.1021/jm201150j
BindingDB Entry DOI: 10.7270/Q2M046JC |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Rattus norvegicus) | BDBM50393586
(CHEMBL2158409)Show SMILES COc1cc(ccc1OC(=O)C(C)C)[C@H]1[C@@](NC(=O)c2ccc(NC(=O)OC(C)(C)C)cc2)([C@@H](c2ccc(OC(=O)C(C)C)c(OC)c2)[C@]1(NC(=O)c1ccc(NC(=O)OC(C)(C)C)cc1)C(O)=O)C(O)=O |r,wU:14.14,48.52,33.35,15.16,wD:48.70,15.73,(35.61,1.08,;34.29,.28,;34.32,-1.26,;33.01,-2.05,;33.04,-3.59,;34.38,-4.34,;35.7,-3.55,;35.68,-2,;37,-1.21,;38.34,-1.96,;39.66,-1.16,;38.37,-3.5,;37.05,-4.29,;39.72,-4.24,;31.73,-4.38,;31.72,-5.92,;32.79,-7.03,;32.78,-8.57,;31.44,-9.33,;34.11,-9.35,;34.09,-10.89,;35.42,-11.67,;36.76,-10.91,;38.09,-11.69,;38.08,-13.23,;39.4,-14.01,;36.74,-13.99,;36.73,-15.53,;35.39,-16.29,;38.06,-16.31,;36.73,-17.07,;36.76,-9.36,;35.44,-8.59,;30.19,-5.92,;29.39,-7.22,;30.12,-8.56,;29.33,-9.89,;27.78,-9.85,;26.98,-11.17,;25.44,-11.13,;24.7,-9.78,;24.64,-12.45,;25.38,-13.8,;23.1,-12.41,;27.04,-8.5,;25.5,-8.46,;24.77,-7.11,;27.84,-7.19,;30.18,-4.38,;29.41,-3.05,;30.18,-1.71,;31.72,-1.71,;29.41,-.38,;30.18,.95,;29.42,2.28,;27.87,2.28,;27.1,3.61,;27.87,4.95,;27.1,6.28,;29.41,4.95,;30.18,6.29,;31.72,6.29,;29.4,7.63,;30.93,7.63,;27.1,.94,;27.88,-.39,;28.64,-4.38,;27.87,-3.05,;27.87,-5.72,;33.26,-5.92,;34.03,-7.25,;33.78,-4.86,)| Show InChI InChI=1S/C52H60N4O16/c1-27(2)43(59)69-35-23-17-31(25-37(35)67-11)39-51(45(61)62,55-41(57)29-13-19-33(20-14-29)53-47(65)71-49(5,6)7)40(32-18-24-36(38(26-32)68-12)70-44(60)28(3)4)52(39,46(63)64)56-42(58)30-15-21-34(22-16-30)54-48(66)72-50(8,9)10/h13-28,39-40H,1-12H3,(H,53,65)(H,54,66)(H,55,57)(H,56,58)(H,61,62)(H,63,64)/t39-,40+,51+,52- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.38E+3 | n/a | n/a | n/a | n/a |
The National Center for Drug Screening
Curated by ChEMBL
| Assay Description
Agonist activity at rat GLP1R expressed in HEK293 cells assessed as stimulation of cAMP levels incubated for 6 hrs by multiple response element/cAMP ... |
J Med Chem 55: 250-67 (2012)
Article DOI: 10.1021/jm201150j
BindingDB Entry DOI: 10.7270/Q2M046JC |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Rattus norvegicus) | BDBM50393568
(CHEMBL2158495)Show SMILES COc1cc(ccc1OC(=O)c1cccs1)[C@H]1[C@@](NC(=O)c2ccc(NC(=S)Nc3cccc4ccccc34)cc2)([C@@H](c2ccc(OC(=O)c3cccs3)c(OC)c2)[C@]1(NC(=O)c1ccc(NC(=S)Nc2cccc3ccccc23)cc1)C(O)=O)C(O)=O |r,wU:41.46,17.19,16.17,58.66,wD:17.95,58.92,(36.68,-8.09,;35.36,-8.88,;34.01,-8.13,;32.69,-8.92,;31.35,-8.17,;31.32,-6.64,;32.63,-5.84,;33.99,-6.59,;35.31,-5.79,;35.28,-4.25,;33.93,-3.51,;36.53,-3.35,;37.99,-3.83,;38.9,-2.58,;38,-1.33,;36.53,-1.81,;30.04,-8.96,;30.03,-10.5,;31.1,-11.62,;31.09,-13.16,;29.75,-13.92,;32.42,-13.94,;32.4,-15.47,;33.73,-16.25,;35.07,-15.49,;36.4,-16.27,;37.74,-15.51,;37.75,-13.97,;39.06,-16.29,;39.05,-17.83,;37.71,-18.59,;37.7,-20.12,;39.03,-20.9,;40.37,-20.13,;41.69,-20.9,;43.02,-20.14,;43.02,-18.6,;41.7,-17.84,;40.38,-18.6,;35.08,-13.95,;33.75,-13.17,;28.49,-10.5,;27.7,-11.8,;28.43,-13.15,;27.64,-14.47,;26.09,-14.44,;25.29,-15.75,;26.03,-17.1,;27.57,-17.14,;25.08,-18.32,;23.54,-18.28,;23.01,-19.73,;24.23,-20.67,;25.51,-19.8,;25.35,-13.08,;23.81,-13.04,;23.07,-11.69,;26.15,-11.77,;28.49,-8.96,;27.72,-7.63,;28.49,-6.3,;30.03,-6.29,;27.72,-4.96,;28.49,-3.63,;27.72,-2.3,;26.18,-2.3,;25.41,-.97,;26.18,.37,;27.72,.37,;25.4,1.7,;26.17,3.03,;27.72,3.03,;28.48,4.36,;27.71,5.7,;26.17,5.69,;25.4,6.99,;23.88,7,;23.12,5.67,;23.88,4.35,;25.4,4.35,;25.41,-3.65,;26.19,-4.97,;26.95,-8.96,;26.18,-7.63,;26.18,-10.3,;31.57,-10.5,;32.34,-11.84,;32.09,-9.44,)| Show InChI InChI=1S/C66H50N6O12S4/c1-81-51-35-41(25-31-49(51)83-59(75)53-19-9-33-87-53)55-65(61(77)78,71-57(73)39-21-27-43(28-22-39)67-63(85)69-47-17-7-13-37-11-3-5-15-45(37)47)56(42-26-32-50(52(36-42)82-2)84-60(76)54-20-10-34-88-54)66(55,62(79)80)72-58(74)40-23-29-44(30-24-40)68-64(86)70-48-18-8-14-38-12-4-6-16-46(38)48/h3-36,55-56H,1-2H3,(H,71,73)(H,72,74)(H,77,78)(H,79,80)(H2,67,69,85)(H2,68,70,86)/t55-,56+,65+,66- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 2.13E+3 | n/a | n/a | n/a | n/a |
The National Center for Drug Screening
Curated by ChEMBL
| Assay Description
Agonist activity at rat GLP1R expressed in HEK293 cells assessed as stimulation of cAMP levels incubated for 6 hrs by multiple response element/cAMP ... |
J Med Chem 55: 250-67 (2012)
Article DOI: 10.1021/jm201150j
BindingDB Entry DOI: 10.7270/Q2M046JC |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Rattus norvegicus) | BDBM50393585
(CHEMBL2158311)Show SMILES COc1cc(ccc1OC(=O)C12CC3CC(CC(C3)C1)C2)[C@H]1[C@@](NC(=O)c2ccc(NC(=O)OC(C)(C)C)cc2)([C@@H](c2ccc(OC(=O)C34CC5CC(CC(C5)C3)C4)c(OC)c2)[C@]1(NC(=O)c1ccc(NC(=O)OC(C)(C)C)cc1)C(O)=O)C(O)=O |r,wU:21.24,62.72,40.45,22.26,wD:62.90,22.93,TLB:9:11:14:18.16.17,THB:19:17:14:20.11.12,19:11:14:18.16.17,53:52:49:55.54.56,53:54:51.52.57:49,56:54:51:57.48.49,56:48:51:55.53.54,16:15:12:18.17.19,16:17:14.15.20:12,(17.48,-8.85,;16.16,-9.64,;16.19,-11.18,;14.88,-11.98,;14.91,-13.51,;16.25,-14.26,;17.57,-13.47,;17.55,-11.93,;18.87,-11.14,;20.22,-11.88,;21.53,-11.09,;20.24,-13.42,;18.9,-13.9,;18.9,-15.39,;17.71,-16.66,;19.21,-16.24,;20.61,-16.81,;21.63,-15.53,;20.23,-15.88,;21.64,-14,;19.2,-14.66,;13.6,-14.31,;13.59,-15.85,;14.66,-16.96,;14.65,-18.5,;13.31,-19.26,;15.98,-19.28,;15.96,-20.82,;17.29,-21.6,;18.63,-20.84,;19.96,-21.62,;19.95,-23.16,;21.28,-23.94,;18.61,-23.92,;18.6,-25.46,;17.26,-26.22,;19.93,-26.24,;18.6,-27,;18.64,-19.29,;17.31,-18.52,;12.06,-15.85,;11.26,-17.14,;11.99,-18.49,;11.2,-19.81,;9.65,-19.78,;8.85,-21.1,;7.31,-21.06,;6.57,-19.71,;6.51,-22.38,;5.08,-22.4,;4.62,-23.82,;3.08,-24.65,;4.64,-24.73,;5.79,-25.7,;7.16,-24.81,;5.72,-24.7,;7.65,-23.37,;5.13,-23.22,;8.91,-18.43,;7.37,-18.39,;6.64,-17.03,;9.71,-17.11,;12.05,-14.31,;11.28,-12.97,;12.05,-11.64,;13.59,-11.64,;11.28,-10.31,;12.05,-8.98,;11.29,-7.65,;9.74,-7.65,;8.97,-6.31,;9.74,-4.98,;8.97,-3.65,;11.28,-4.98,;12.05,-3.64,;13.59,-3.64,;11.27,-2.31,;12.8,-2.3,;8.97,-8.99,;9.75,-10.32,;10.51,-14.31,;9.74,-12.98,;9.74,-15.64,;15.13,-15.85,;15.9,-17.18,;15.65,-14.78,)| Show InChI InChI=1S/C66H76N4O16/c1-61(2,3)85-59(79)67-45-15-9-41(10-16-45)53(71)69-65(55(73)74)51(43-13-19-47(49(27-43)81-7)83-57(77)63-29-35-21-36(30-63)23-37(22-35)31-63)66(56(75)76,70-54(72)42-11-17-46(18-12-42)68-60(80)86-62(4,5)6)52(65)44-14-20-48(50(28-44)82-8)84-58(78)64-32-38-24-39(33-64)26-40(25-38)34-64/h9-20,27-28,35-40,51-52H,21-26,29-34H2,1-8H3,(H,67,79)(H,68,80)(H,69,71)(H,70,72)(H,73,74)(H,75,76)/t35?,36?,37?,38?,39?,40?,51-,52+,63?,64?,65+,66- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 2.15E+3 | n/a | n/a | n/a | n/a |
The National Center for Drug Screening
Curated by ChEMBL
| Assay Description
Agonist activity at rat GLP1R expressed in HEK293 cells assessed as stimulation of cAMP levels incubated for 6 hrs by multiple response element/cAMP ... |
J Med Chem 55: 250-67 (2012)
Article DOI: 10.1021/jm201150j
BindingDB Entry DOI: 10.7270/Q2M046JC |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Rattus norvegicus) | BDBM50393588
(CHEMBL2158407)Show SMILES CCC(=O)Oc1ccc(cc1OC)[C@H]1[C@@](NC(=O)c2ccc(NC(=O)OC(C)(C)C)cc2)([C@@H](c2ccc(OC(=O)CC)c(OC)c2)[C@]1(NC(=O)c1ccc(NC(=O)OC(C)(C)C)cc1)C(O)=O)C(O)=O |r,wU:13.13,46.50,32.34,14.15,wD:46.68,14.71,(30.57,-26.73,;31.89,-25.94,;31.86,-24.4,;33.18,-23.6,;30.51,-23.65,;29.19,-24.44,;29.22,-25.99,;27.9,-26.78,;26.56,-26.03,;26.52,-24.49,;27.83,-23.7,;27.8,-22.16,;29.12,-21.36,;25.24,-26.82,;25.24,-28.36,;26.31,-29.47,;26.29,-31.01,;24.96,-31.77,;27.62,-31.79,;27.6,-33.33,;28.93,-34.11,;30.27,-33.35,;31.6,-34.13,;31.59,-35.67,;32.92,-36.45,;30.25,-36.43,;30.24,-37.97,;28.9,-38.73,;31.57,-38.75,;30.25,-39.51,;30.28,-31.8,;28.95,-31.03,;23.7,-28.36,;22.9,-29.65,;23.63,-31,;22.84,-32.33,;21.29,-32.29,;20.49,-33.61,;18.95,-33.57,;18.21,-32.22,;18.15,-34.89,;16.61,-34.85,;20.56,-30.94,;19.02,-30.9,;18.28,-29.55,;21.36,-29.63,;23.69,-26.82,;22.93,-25.49,;23.7,-24.15,;25.24,-24.15,;22.92,-22.82,;23.7,-21.49,;22.93,-20.16,;21.39,-20.16,;20.61,-18.83,;21.38,-17.49,;20.61,-16.16,;22.92,-17.49,;23.69,-16.15,;25.23,-16.15,;22.92,-14.82,;24.45,-14.81,;20.62,-21.5,;21.39,-22.83,;22.15,-26.82,;21.38,-25.49,;21.38,-28.15,;26.77,-28.36,;27.54,-29.69,;27.29,-27.3,)| Show InChI InChI=1S/C50H56N4O16/c1-11-37(55)67-33-23-17-29(25-35(33)65-9)39-49(43(59)60,53-41(57)27-13-19-31(20-14-27)51-45(63)69-47(3,4)5)40(30-18-24-34(36(26-30)66-10)68-38(56)12-2)50(39,44(61)62)54-42(58)28-15-21-32(22-16-28)52-46(64)70-48(6,7)8/h13-26,39-40H,11-12H2,1-10H3,(H,51,63)(H,52,64)(H,53,57)(H,54,58)(H,59,60)(H,61,62)/t39-,40+,49+,50- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a |
The National Center for Drug Screening
Curated by ChEMBL
| Assay Description
Agonist activity at rat GLP1R expressed in HEK293 cells assessed as stimulation of cAMP levels incubated for 6 hrs by multiple response element/cAMP ... |
J Med Chem 55: 250-67 (2012)
Article DOI: 10.1021/jm201150j
BindingDB Entry DOI: 10.7270/Q2M046JC |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Rattus norvegicus) | BDBM50393567
(CHEMBL2158496)Show SMILES COc1cc(ccc1OC(=O)c1cccs1)[C@H]1[C@@](NC(=O)c2ccc(NC(=O)Nc3cccc(F)c3)cc2)([C@@H](c2ccc(OC(=O)c3cccs3)c(OC)c2)[C@]1(NC(=O)c1ccc(NC(=O)Nc2cccc(F)c2)cc1)C(O)=O)C(O)=O |r,wU:38.42,17.19,16.17,55.62,wD:17.87,55.84,(8.03,-34.99,;6.71,-35.79,;5.36,-35.04,;4.04,-35.83,;2.7,-35.08,;2.67,-33.55,;3.98,-32.75,;5.34,-33.5,;6.66,-32.7,;6.63,-31.16,;5.28,-30.42,;7.88,-30.26,;9.34,-30.74,;10.25,-29.49,;9.34,-28.24,;7.88,-28.72,;1.38,-35.87,;1.38,-37.41,;2.45,-38.53,;2.44,-40.07,;1.1,-40.82,;3.77,-40.85,;3.75,-42.38,;5.07,-43.16,;6.42,-42.4,;7.74,-43.18,;9.08,-42.42,;9.09,-40.88,;10.41,-43.2,;10.4,-44.74,;9.06,-45.49,;9.05,-47.03,;10.38,-47.81,;11.72,-47.04,;13.05,-47.82,;11.72,-45.51,;6.42,-40.85,;5.1,-40.08,;-.16,-37.41,;-.95,-38.71,;-.23,-40.06,;-1.01,-41.38,;-2.56,-41.35,;-3.36,-42.66,;-2.62,-44.01,;-1.08,-44.05,;-3.57,-45.23,;-5.11,-45.19,;-5.64,-46.63,;-4.42,-47.58,;-3.14,-46.71,;-3.3,-39.99,;-4.84,-39.95,;-5.57,-38.6,;-2.5,-38.68,;-.16,-35.87,;-.93,-34.54,;-.16,-33.21,;1.38,-33.2,;-.93,-31.87,;-.16,-30.54,;-.93,-29.21,;-2.47,-29.21,;-3.24,-27.88,;-2.47,-26.54,;-.93,-26.54,;-3.25,-25.21,;-2.48,-23.88,;-3.26,-22.56,;-2.5,-21.22,;-.95,-21.22,;-.18,-22.55,;1.36,-22.55,;-.94,-23.88,;-3.24,-30.56,;-2.46,-31.88,;-1.7,-35.87,;-2.47,-34.54,;-2.47,-37.21,;2.92,-37.41,;3.69,-38.74,;3.44,-36.35,)| Show InChI InChI=1S/C58H44F2N6O14S2/c1-77-43-27-33(17-23-41(43)79-51(69)45-11-5-25-81-45)47-57(53(71)72,65-49(67)31-13-19-37(20-14-31)61-55(75)63-39-9-3-7-35(59)29-39)48(34-18-24-42(44(28-34)78-2)80-52(70)46-12-6-26-82-46)58(47,54(73)74)66-50(68)32-15-21-38(22-16-32)62-56(76)64-40-10-4-8-36(60)30-40/h3-30,47-48H,1-2H3,(H,65,67)(H,66,68)(H,71,72)(H,73,74)(H2,61,63,75)(H2,62,64,76)/t47-,48+,57+,58- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 2.71E+3 | n/a | n/a | n/a | n/a |
The National Center for Drug Screening
Curated by ChEMBL
| Assay Description
Agonist activity at rat GLP1R expressed in HEK293 cells assessed as stimulation of cAMP levels incubated for 6 hrs by multiple response element/cAMP ... |
J Med Chem 55: 250-67 (2012)
Article DOI: 10.1021/jm201150j
BindingDB Entry DOI: 10.7270/Q2M046JC |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Rattus norvegicus) | BDBM50260246
(1,3-bis(4-(tert-butoxycarbonyl)benzamido)-2,4-bis(...)Show SMILES COc1cc(ccc1OC(=O)c1cccs1)C1C(NC(=O)c2ccc(NC(=O)OC(C)(C)C)cc2)(C(c2ccc(OC(=O)c3cccs3)c(OC)c2)C1(NC(=O)c1ccc(NC(=O)OC(C)(C)C)cc1)C(O)=O)C(O)=O |(.32,-12.51,;1.08,-13.85,;2.62,-13.86,;3.39,-12.53,;4.93,-12.54,;5.69,-13.87,;4.93,-15.19,;3.38,-15.19,;2.61,-16.52,;1.07,-16.52,;.3,-15.18,;.3,-17.85,;-1.23,-18.01,;-1.55,-19.51,;-.22,-20.29,;.93,-19.26,;4.93,-10.99,;4.93,-9.45,;4.92,-7.9,;3.56,-7.14,;2.02,-7.16,;3.56,-5.61,;4.89,-4.84,;4.89,-3.3,;3.55,-2.53,;3.55,-.99,;4.88,-.21,;6.22,-.98,;4.87,1.33,;6.21,2.1,;7.53,2.89,;6.99,.77,;5.43,3.43,;2.22,-3.31,;2.23,-4.85,;6.47,-9.45,;6.46,-7.9,;5.7,-6.57,;6.46,-5.25,;8,-5.24,;8.77,-3.91,;10.31,-3.9,;11.08,-5.24,;11.07,-2.57,;12.6,-2.4,;12.92,-.9,;11.58,-.13,;10.44,-1.16,;8.77,-6.57,;10.31,-6.57,;11.08,-7.91,;8,-7.9,;6.47,-10.99,;6.48,-12.53,;7.83,-13.3,;9.37,-13.29,;7.82,-14.84,;6.48,-15.6,;6.47,-17.14,;7.8,-17.92,;7.8,-19.46,;6.46,-20.22,;5.13,-19.45,;6.45,-21.76,;5.12,-22.53,;3.77,-23.29,;5.88,-23.87,;4.36,-21.19,;9.14,-17.14,;9.15,-15.61,;8.02,-11.01,;8.77,-12.35,;8.8,-9.68,;3.39,-9.44,;2.62,-8.1,;2.61,-10.77,)| Show InChI InChI=1S/C54H52N4O16S2/c1-51(2,3)73-49(67)55-33-19-13-29(14-20-33)43(59)57-53(47(63)64)41(31-17-23-35(37(27-31)69-7)71-45(61)39-11-9-25-75-39)54(48(65)66,58-44(60)30-15-21-34(22-16-30)56-50(68)74-52(4,5)6)42(53)32-18-24-36(38(28-32)70-8)72-46(62)40-12-10-26-76-40/h9-28,41-42H,1-8H3,(H,55,67)(H,56,68)(H,57,59)(H,58,60)(H,63,64)(H,65,66) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PDB
Article
PubMed
| n/a | n/a | n/a | n/a | 2.73E+3 | n/a | n/a | n/a | n/a |
National Center for Drug Screening
Curated by ChEMBL
| Assay Description
Agonist activity at rat GLP1 receptor expressed in HEK293 cells assessed as cAMP release |
Proc Natl Acad Sci U S A 104: 943-8 (2007)
Article DOI: 10.1073/pnas.0610173104
BindingDB Entry DOI: 10.7270/Q2TM79VV |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Glucagon-like peptide 1 receptor
(Rattus norvegicus) | BDBM50393587
(CHEMBL2158408)Show SMILES CCCC(=O)Oc1ccc(cc1OC)[C@H]1[C@@](NC(=O)c2ccc(NC(=O)OC(C)(C)C)cc2)([C@@H](c2ccc(OC(=O)CCC)c(OC)c2)[C@]1(NC(=O)c1ccc(NC(=O)OC(C)(C)C)cc1)C(O)=O)C(O)=O |r,wU:14.14,48.52,33.35,15.16,wD:48.70,15.73,(11.3,-3.28,;11.27,-1.74,;9.92,-.99,;9.89,.55,;11.21,1.34,;8.55,1.29,;7.23,.5,;7.25,-1.04,;5.93,-1.83,;4.59,-1.08,;4.56,.45,;5.87,1.25,;5.84,2.79,;7.16,3.58,;3.27,-1.87,;3.27,-3.42,;4.34,-4.53,;4.33,-6.07,;2.99,-6.83,;5.66,-6.85,;5.64,-8.39,;6.96,-9.17,;8.31,-8.41,;9.63,-9.19,;9.62,-10.73,;10.95,-11.5,;8.29,-11.49,;8.28,-13.03,;6.94,-13.79,;9.6,-13.8,;8.28,-14.57,;8.31,-6.86,;6.99,-6.08,;1.73,-3.41,;.94,-4.71,;1.66,-6.06,;.88,-7.38,;-.67,-7.35,;-1.47,-8.66,;-3.01,-8.63,;-3.75,-7.28,;-3.81,-9.94,;-3.07,-11.3,;-3.88,-12.61,;-1.41,-5.99,;-2.95,-5.96,;-3.68,-4.6,;-.61,-4.68,;1.73,-1.88,;.96,-.54,;1.73,.79,;3.27,.79,;.96,2.12,;1.73,3.45,;.96,4.78,;-.58,4.78,;-1.35,6.12,;-.58,7.45,;-1.36,8.79,;.96,7.45,;1.72,8.8,;3.26,8.8,;.95,10.13,;2.48,10.13,;-1.35,3.44,;-.57,2.11,;.19,-1.88,;-.58,-.54,;-.58,-3.21,;4.81,-3.41,;5.58,-4.75,;5.33,-2.35,)| Show InChI InChI=1S/C52H60N4O16/c1-11-13-39(57)69-35-25-19-31(27-37(35)67-9)41-51(45(61)62,55-43(59)29-15-21-33(22-16-29)53-47(65)71-49(3,4)5)42(32-20-26-36(38(28-32)68-10)70-40(58)14-12-2)52(41,46(63)64)56-44(60)30-17-23-34(24-18-30)54-48(66)72-50(6,7)8/h15-28,41-42H,11-14H2,1-10H3,(H,53,65)(H,54,66)(H,55,59)(H,56,60)(H,61,62)(H,63,64)/t41-,42+,51+,52- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 3.33E+3 | n/a | n/a | n/a | n/a |
The National Center for Drug Screening
Curated by ChEMBL
| Assay Description
Agonist activity at rat GLP1R expressed in HEK293 cells assessed as stimulation of cAMP levels incubated for 6 hrs by multiple response element/cAMP ... |
J Med Chem 55: 250-67 (2012)
Article DOI: 10.1021/jm201150j
BindingDB Entry DOI: 10.7270/Q2M046JC |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Rattus norvegicus) | BDBM50393570
(CHEMBL2158492)Show SMILES COc1cc(ccc1OC(=O)c1cccs1)[C@H]1[C@@](NC(=O)c2ccc(NC(=O)CCl)cc2)([C@@H](c2ccc(OC(=O)c3cccs3)c(OC)c2)[C@]1(NC(=O)c1ccc(NC(=O)CCl)cc1)C(O)=O)C(O)=O |r,wU:16.17,49.55,32.35,17.19,wD:49.70,17.73,(8.11,-32.7,;6.79,-33.49,;5.44,-32.74,;4.12,-33.54,;2.78,-32.79,;2.74,-31.25,;4.06,-30.46,;5.41,-31.2,;6.73,-30.41,;6.71,-28.87,;5.36,-28.12,;7.95,-27.97,;9.42,-28.44,;10.33,-27.2,;9.42,-25.95,;7.96,-26.42,;1.46,-33.58,;1.46,-35.12,;2.53,-36.23,;2.52,-37.77,;1.18,-38.53,;3.85,-38.55,;3.83,-40.09,;5.15,-40.87,;6.49,-40.11,;7.82,-40.89,;7.81,-42.43,;9.14,-43.21,;6.47,-43.19,;5.15,-42.41,;6.5,-38.56,;5.17,-37.79,;-.08,-35.12,;-.87,-36.41,;-.15,-37.76,;-.94,-39.08,;-2.48,-39.05,;-3.28,-40.37,;-2.55,-41.72,;-1.01,-41.75,;-3.49,-42.94,;-5.04,-42.89,;-5.56,-44.34,;-4.34,-45.28,;-3.07,-44.42,;-3.22,-37.7,;-4.76,-37.66,;-5.5,-36.31,;-2.42,-36.38,;-.08,-33.58,;-.85,-32.24,;-.08,-30.91,;1.46,-30.91,;-.85,-29.58,;-.08,-28.25,;-.85,-26.92,;-2.39,-26.92,;-3.16,-25.59,;-2.39,-24.25,;-3.17,-22.92,;-.85,-24.25,;-.08,-25.58,;-3.16,-28.26,;-2.38,-29.59,;-1.63,-33.58,;-2.4,-32.25,;-2.39,-34.91,;2.99,-35.12,;3.77,-36.45,;3.51,-34.05,)| Show InChI InChI=1S/C48H38Cl2N4O14S2/c1-65-33-21-27(11-17-31(33)67-43(59)35-5-3-19-69-35)39-47(45(61)62,53-41(57)25-7-13-29(14-8-25)51-37(55)23-49)40(28-12-18-32(34(22-28)66-2)68-44(60)36-6-4-20-70-36)48(39,46(63)64)54-42(58)26-9-15-30(16-10-26)52-38(56)24-50/h3-22,39-40H,23-24H2,1-2H3,(H,51,55)(H,52,56)(H,53,57)(H,54,58)(H,61,62)(H,63,64)/t39-,40+,47+,48- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 3.80E+3 | n/a | n/a | n/a | n/a |
The National Center for Drug Screening
Curated by ChEMBL
| Assay Description
Agonist activity at rat GLP1R expressed in HEK293 cells assessed as stimulation of cAMP levels incubated for 6 hrs by multiple response element/cAMP ... |
J Med Chem 55: 250-67 (2012)
Article DOI: 10.1021/jm201150j
BindingDB Entry DOI: 10.7270/Q2M046JC |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Rattus norvegicus) | BDBM50393566
(CHEMBL2158497)Show SMILES CCOC(=O)CNC(=O)Nc1ccc(cc1)C(=O)N[C@@]1([C@H](c2ccc(OC(=O)c3cccs3)c(OC)c2)[C@](NC(=O)c2ccc(NC(=O)NCC(=O)OCC)cc2)([C@@H]1c1ccc(OC(=O)c2cccs2)c(OC)c1)C(O)=O)C(O)=O |r,wU:57.62,19.19,20.21,37.40,wD:19.83,37.80,(36.12,-48.39,;36.13,-46.85,;37.47,-46.09,;37.48,-44.55,;36.15,-43.77,;38.81,-43.79,;38.82,-42.25,;37.5,-41.47,;37.51,-39.93,;36.16,-42.23,;34.83,-41.45,;33.49,-42.21,;32.16,-41.43,;32.18,-39.9,;33.51,-39.13,;34.84,-39.91,;30.85,-39.12,;29.51,-39.88,;30.86,-37.58,;29.8,-36.46,;29.8,-34.92,;31.12,-34.13,;31.08,-32.6,;32.39,-31.8,;33.75,-32.55,;35.07,-31.75,;35.04,-30.21,;33.69,-29.47,;36.29,-29.31,;37.75,-29.79,;38.66,-28.54,;37.76,-27.3,;36.29,-27.77,;33.77,-34.09,;35.12,-34.84,;36.44,-34.05,;32.45,-34.88,;28.25,-34.92,;27.48,-33.59,;28.25,-32.26,;29.79,-32.26,;27.48,-30.92,;28.26,-29.6,;27.49,-28.26,;25.94,-28.26,;25.17,-26.93,;25.94,-25.6,;27.48,-25.59,;25.17,-24.26,;25.93,-22.93,;27.47,-22.93,;28.25,-24.26,;28.24,-21.59,;29.78,-21.59,;30.55,-20.25,;25.18,-29.61,;25.95,-30.93,;28.26,-36.46,;27.46,-37.76,;28.19,-39.11,;27.4,-40.43,;25.85,-40.4,;25.05,-41.71,;25.79,-43.06,;27.33,-43.1,;24.84,-44.28,;23.3,-44.24,;22.78,-45.69,;23.99,-46.63,;25.27,-45.76,;25.11,-39.04,;23.57,-39,;22.84,-37.65,;25.92,-37.73,;26.71,-34.93,;25.94,-33.59,;25.94,-36.26,;31.33,-36.46,;32.1,-37.8,;31.85,-35.4,)| Show InChI InChI=1S/C54H50N6O18S2/c1-5-75-41(61)27-55-51(71)57-33-17-11-29(12-18-33)45(63)59-53(49(67)68)43(31-15-21-35(37(25-31)73-3)77-47(65)39-9-7-23-79-39)54(50(69)70,44(53)32-16-22-36(38(26-32)74-4)78-48(66)40-10-8-24-80-40)60-46(64)30-13-19-34(20-14-30)58-52(72)56-28-42(62)76-6-2/h7-26,43-44H,5-6,27-28H2,1-4H3,(H,59,63)(H,60,64)(H,67,68)(H,69,70)(H2,55,57,71)(H2,56,58,72)/t43-,44+,53+,54- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 4.50E+3 | n/a | n/a | n/a | n/a |
The National Center for Drug Screening
Curated by ChEMBL
| Assay Description
Agonist activity at rat GLP1R expressed in HEK293 cells assessed as stimulation of cAMP levels incubated for 6 hrs by multiple response element/cAMP ... |
J Med Chem 55: 250-67 (2012)
Article DOI: 10.1021/jm201150j
BindingDB Entry DOI: 10.7270/Q2M046JC |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Rattus norvegicus) | BDBM50393589
(CHEMBL2158406)Show SMILES COc1cc(ccc1OC(C)=O)[C@H]1[C@@](NC(=O)c2ccc(NC(=O)OC(C)(C)C)cc2)([C@@H](c2ccc(OC(C)=O)c(OC)c2)[C@]1(NC(=O)c1ccc(NC(=O)OC(C)(C)C)cc1)C(O)=O)C(O)=O |r,wU:12.12,44.48,31.33,13.14,wD:44.66,13.69,(5.44,-26.86,;4.12,-27.66,;4.15,-29.2,;2.84,-29.99,;2.87,-31.53,;4.21,-32.28,;5.53,-31.48,;5.51,-29.94,;6.83,-29.15,;8.17,-29.89,;8.2,-31.43,;9.49,-29.1,;1.56,-32.32,;1.55,-33.86,;2.62,-34.97,;2.61,-36.51,;1.27,-37.27,;3.94,-37.29,;3.92,-38.83,;5.25,-39.61,;6.59,-38.85,;7.92,-39.63,;7.91,-41.17,;9.23,-41.95,;6.57,-41.93,;6.56,-43.47,;5.22,-44.23,;7.89,-44.25,;6.56,-45.01,;6.59,-37.3,;5.27,-36.53,;.02,-33.86,;-.78,-35.15,;-.05,-36.5,;-.84,-37.82,;-2.39,-37.79,;-3.19,-39.11,;-4.73,-39.07,;-5.53,-40.39,;-5.47,-37.72,;-3.13,-36.44,;-4.67,-36.4,;-5.4,-35.05,;-2.33,-35.12,;.01,-32.32,;-.76,-30.98,;.01,-29.65,;1.55,-29.65,;-.76,-28.32,;.01,-26.99,;-.75,-25.66,;-2.3,-25.66,;-3.07,-24.33,;-2.3,-22.99,;-3.07,-21.66,;-.76,-22.99,;.01,-21.65,;1.55,-21.65,;-.77,-20.32,;.76,-20.31,;-3.07,-27,;-2.29,-28.33,;-1.53,-32.32,;-2.3,-30.99,;-2.3,-33.65,;3.09,-33.86,;3.86,-35.19,;3.61,-32.79,)| Show InChI InChI=1S/C48H52N4O16/c1-25(53)65-33-21-15-29(23-35(33)63-9)37-47(41(57)58,51-39(55)27-11-17-31(18-12-27)49-43(61)67-45(3,4)5)38(30-16-22-34(66-26(2)54)36(24-30)64-10)48(37,42(59)60)52-40(56)28-13-19-32(20-14-28)50-44(62)68-46(6,7)8/h11-24,37-38H,1-10H3,(H,49,61)(H,50,62)(H,51,55)(H,52,56)(H,57,58)(H,59,60)/t37-,38+,47+,48- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 8.31E+3 | n/a | n/a | n/a | n/a |
The National Center for Drug Screening
Curated by ChEMBL
| Assay Description
Agonist activity at rat GLP1R expressed in HEK293 cells assessed as stimulation of cAMP levels incubated for 6 hrs by multiple response element/cAMP ... |
J Med Chem 55: 250-67 (2012)
Article DOI: 10.1021/jm201150j
BindingDB Entry DOI: 10.7270/Q2M046JC |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Rattus norvegicus) | BDBM50393569
(CHEMBL2158494)Show SMILES CNC(=S)Nc1ccc(cc1)C(=O)N[C@@]1([C@H](c2ccc(OC(=O)c3cccs3)c(OC)c2)[C@](NC(=O)c2ccc(NC(=S)NC)cc2)([C@@H]1c1ccc(OC(=O)c2cccs2)c(OC)c1)C(O)=O)C(O)=O |r,wU:47.52,14.14,15.16,32.35,wD:32.70,14.73,(11.33,-15.19,;11.34,-13.65,;10.01,-12.87,;10.02,-11.33,;8.67,-13.63,;7.34,-12.86,;6,-13.61,;4.67,-12.83,;4.69,-11.3,;6.02,-10.53,;7.35,-11.31,;3.37,-10.52,;2.03,-11.28,;3.38,-8.98,;2.31,-7.86,;2.31,-6.32,;3.63,-5.53,;3.59,-4,;4.91,-3.2,;6.26,-3.95,;7.58,-3.16,;7.55,-1.62,;6.21,-.87,;8.8,-.71,;10.27,-1.19,;11.17,.06,;10.27,1.3,;8.8,.83,;6.29,-5.49,;7.63,-6.24,;8.95,-5.45,;4.97,-6.28,;.77,-6.33,;-0,-4.99,;.77,-3.66,;2.31,-3.66,;-0,-2.32,;.77,-1,;-0,.34,;-1.54,.34,;-2.31,1.67,;-1.55,3,;-.01,3.01,;-2.32,4.34,;-1.55,5.67,;-2.31,-1.01,;-1.54,-2.33,;.77,-7.86,;-.02,-9.16,;.7,-10.51,;-.09,-11.83,;-1.64,-11.8,;-2.44,-13.11,;-1.7,-14.46,;-.16,-14.5,;-2.64,-15.68,;-4.19,-15.64,;-4.71,-17.09,;-3.49,-18.03,;-2.22,-17.16,;-2.37,-10.44,;-3.91,-10.4,;-4.65,-9.05,;-1.57,-9.13,;-.78,-6.33,;-1.55,-4.99,;-1.55,-7.66,;3.84,-7.86,;4.61,-9.2,;4.36,-6.8,)| Show InChI InChI=1S/C48H42N6O12S4/c1-49-45(67)51-29-15-9-25(10-16-29)39(55)53-47(43(59)60)37(27-13-19-31(33(23-27)63-3)65-41(57)35-7-5-21-69-35)48(44(61)62,54-40(56)26-11-17-30(18-12-26)52-46(68)50-2)38(47)28-14-20-32(34(24-28)64-4)66-42(58)36-8-6-22-70-36/h5-24,37-38H,1-4H3,(H,53,55)(H,54,56)(H,59,60)(H,61,62)(H2,49,51,67)(H2,50,52,68)/t37-,38+,47+,48- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 9.12E+3 | n/a | n/a | n/a | n/a |
The National Center for Drug Screening
Curated by ChEMBL
| Assay Description
Agonist activity at rat GLP1R expressed in HEK293 cells assessed as stimulation of cAMP levels incubated for 6 hrs by multiple response element/cAMP ... |
J Med Chem 55: 250-67 (2012)
Article DOI: 10.1021/jm201150j
BindingDB Entry DOI: 10.7270/Q2M046JC |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Rattus norvegicus) | BDBM50393598
(CHEMBL2158393)Show SMILES COc1ccc(cc1)[C@H]1[C@@](NC(=O)c2ccc(NC(=O)OC(C)(C)C)cc2)([C@@H](c2ccc(OC)cc2)[C@]1(NC(=O)c1ccc(NC(=O)OC(C)(C)C)cc1)C(O)=O)C(O)=O |r,wU:8.8,36.40,27.29,9.10,wD:36.58,9.61,(8.03,-28.87,;8.06,-30.41,;6.74,-31.2,;6.76,-32.74,;5.44,-33.54,;4.1,-32.79,;4.07,-31.25,;5.38,-30.46,;2.78,-33.58,;2.78,-35.12,;3.85,-36.23,;3.84,-37.77,;2.5,-38.53,;5.17,-38.55,;5.15,-40.09,;6.47,-40.87,;7.82,-40.11,;9.14,-40.89,;9.13,-42.43,;10.46,-43.21,;7.8,-43.19,;7.79,-44.73,;6.45,-45.49,;9.11,-45.51,;7.79,-46.27,;7.82,-38.56,;6.5,-37.79,;1.24,-35.12,;.45,-36.41,;-1.1,-36.38,;-1.9,-37.7,;-1.16,-39.05,;-1.96,-40.37,;-3.5,-40.33,;.39,-39.08,;1.17,-37.76,;1.24,-33.58,;.47,-32.24,;1.24,-30.91,;2.78,-30.91,;.47,-29.58,;1.24,-28.25,;.47,-26.92,;-1.07,-26.92,;-1.84,-25.59,;-1.07,-24.25,;-1.85,-22.92,;.47,-24.25,;1.23,-22.91,;2.77,-22.91,;.46,-21.58,;1.99,-21.57,;-1.84,-28.26,;-1.06,-29.59,;-.3,-33.58,;-1.07,-32.25,;-1.07,-34.91,;4.32,-35.12,;5.09,-36.45,;4.84,-34.05,)| Show InChI InChI=1S/C44H48N4O12/c1-41(2,3)59-39(55)45-29-17-9-27(10-18-29)35(49)47-43(37(51)52)33(25-13-21-31(57-7)22-14-25)44(38(53)54,34(43)26-15-23-32(58-8)24-16-26)48-36(50)28-11-19-30(20-12-28)46-40(56)60-42(4,5)6/h9-24,33-34H,1-8H3,(H,45,55)(H,46,56)(H,47,49)(H,48,50)(H,51,52)(H,53,54)/t33-,34+,43+,44- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 9.40E+3 | n/a | n/a | n/a | n/a |
The National Center for Drug Screening
Curated by ChEMBL
| Assay Description
Agonist activity at rat GLP1R expressed in HEK293 cells assessed as stimulation of cAMP levels incubated for 6 hrs by multiple response element/cAMP ... |
J Med Chem 55: 250-67 (2012)
Article DOI: 10.1021/jm201150j
BindingDB Entry DOI: 10.7270/Q2M046JC |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Rattus norvegicus) | BDBM50393581
(CHEMBL2158316)Show SMILES COc1cc(ccc1OC(=O)C1CCC1)[C@H]1[C@@](NC(=O)c2ccc(NC(=O)C(C)C)cc2)([C@@H](c2ccc(OC(=O)C3CCC3)c(OC)c2)[C@]1(NC(=O)c1ccc(NC(=O)C(C)C)cc1)C(O)=O)C(O)=O |r,wU:15.16,48.54,32.35,16.18,wD:48.70,16.73,(8.33,2.38,;7.01,1.58,;7.04,.04,;5.73,-.75,;5.77,-2.29,;7.11,-3.04,;8.43,-2.25,;8.4,-.71,;9.72,.09,;11.07,-.66,;12.39,.14,;11.1,-2.19,;10.03,-3.3,;11.13,-4.37,;12.2,-3.26,;4.45,-3.08,;4.45,-4.62,;5.52,-5.73,;5.5,-7.27,;4.17,-8.03,;6.83,-8.05,;6.81,-9.59,;8.14,-10.37,;9.48,-9.61,;10.81,-10.39,;10.8,-11.93,;12.13,-12.71,;9.46,-12.69,;8.13,-11.91,;9.45,-14.23,;9.49,-8.06,;8.16,-7.29,;2.91,-4.62,;2.11,-5.92,;2.84,-7.27,;2.05,-8.59,;.5,-8.55,;-.3,-9.87,;-1.84,-9.83,;-2.58,-8.48,;-2.63,-11.15,;-4.13,-11.51,;-3.77,-13.01,;-2.27,-12.65,;-.23,-7.2,;-1.77,-7.16,;-2.51,-5.81,;.57,-5.89,;2.9,-3.08,;2.14,-1.75,;2.91,-.41,;4.45,-.41,;2.13,.92,;2.91,2.25,;2.14,3.58,;.6,3.58,;-.18,4.91,;.59,6.25,;-.18,7.59,;2.13,6.25,;2.9,4.92,;2.9,7.6,;-.17,2.24,;.6,.91,;1.36,-3.08,;.59,-1.75,;.59,-4.42,;5.98,-4.62,;6.75,-5.95,;6.5,-3.56,)| Show InChI InChI=1S/C52H56N4O14/c1-27(2)43(57)53-35-19-13-29(14-20-35)45(59)55-51(49(63)64)41(33-17-23-37(39(25-33)67-5)69-47(61)31-9-7-10-31)52(50(65)66,56-46(60)30-15-21-36(22-16-30)54-44(58)28(3)4)42(51)34-18-24-38(40(26-34)68-6)70-48(62)32-11-8-12-32/h13-28,31-32,41-42H,7-12H2,1-6H3,(H,53,57)(H,54,58)(H,55,59)(H,56,60)(H,63,64)(H,65,66)/t41-,42+,51+,52- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.58E+4 | n/a | n/a | n/a | n/a |
The National Center for Drug Screening
Curated by ChEMBL
| Assay Description
Agonist activity at rat GLP1R expressed in HEK293 cells assessed as stimulation of cAMP levels incubated for 6 hrs by multiple response element/cAMP ... |
J Med Chem 55: 250-67 (2012)
Article DOI: 10.1021/jm201150j
BindingDB Entry DOI: 10.7270/Q2M046JC |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Rattus norvegicus) | BDBM50393583
(CHEMBL2158313)Show SMILES COc1cc(ccc1OC(=O)c1ccc(C)s1)[C@H]1[C@@](NC(=O)c2ccc(NC(=O)OC(C)(C)C)cc2)([C@@H](c2ccc(OC(=O)c3ccc(C)s3)c(OC)c2)[C@]1(NC(=O)c1ccc(NC(=O)OC(C)(C)C)cc1)C(O)=O)C(O)=O |r,wU:36.39,18.20,17.18,54.60,wD:18.81,54.78,(-.94,-8.57,;-.2,-9.92,;1.34,-9.96,;2.14,-8.65,;3.69,-8.68,;4.41,-10.03,;3.62,-11.35,;2.07,-11.32,;1.27,-12.63,;-.27,-12.59,;-1.01,-11.24,;-1.15,-13.86,;-.64,-15.32,;-1.87,-16.25,;-3.13,-15.37,;-4.59,-15.87,;-2.68,-13.9,;4.48,-7.38,;4.48,-5.84,;3.71,-4.51,;4.48,-3.18,;6.02,-3.17,;3.71,-1.84,;4.48,-.51,;3.71,.82,;2.17,.82,;1.4,2.15,;2.16,3.49,;1.39,4.82,;3.7,3.49,;4.47,4.82,;6.01,4.83,;3.7,6.16,;5.23,6.17,;1.4,-.53,;2.17,-1.85,;6.02,-5.84,;7.34,-5.05,;8.68,-5.8,;10,-5.01,;9.97,-3.47,;11.29,-2.67,;12.64,-3.42,;13.96,-2.62,;12.67,-4.96,;11.44,-5.89,;11.94,-7.35,;13.48,-7.32,;14.41,-8.55,;13.93,-5.85,;8.62,-2.72,;8.58,-1.18,;9.9,-.38,;7.3,-3.52,;6.02,-7.38,;7.09,-8.5,;7.08,-10.04,;5.74,-10.79,;8.4,-10.82,;8.38,-12.35,;9.71,-13.13,;11.05,-12.37,;12.38,-13.15,;12.37,-14.69,;13.7,-15.47,;11.03,-15.45,;11.02,-16.99,;9.68,-17.75,;12.35,-17.77,;11.03,-18.54,;11.06,-10.82,;9.73,-10.05,;7.55,-7.38,;8.32,-8.71,;8.07,-6.32,;2.93,-5.84,;2.16,-4.51,;2.16,-7.18,)| Show InChI InChI=1S/C56H56N4O16S2/c1-29-11-25-41(77-29)47(63)73-37-23-17-33(27-39(37)71-9)43-55(49(65)66,59-45(61)31-13-19-35(20-14-31)57-51(69)75-53(3,4)5)44(34-18-24-38(40(28-34)72-10)74-48(64)42-26-12-30(2)78-42)56(43,50(67)68)60-46(62)32-15-21-36(22-16-32)58-52(70)76-54(6,7)8/h11-28,43-44H,1-10H3,(H,57,69)(H,58,70)(H,59,61)(H,60,62)(H,65,66)(H,67,68)/t43-,44+,55+,56- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.91E+4 | n/a | n/a | n/a | n/a |
The National Center for Drug Screening
Curated by ChEMBL
| Assay Description
Agonist activity at rat GLP1R expressed in HEK293 cells assessed as stimulation of cAMP levels incubated for 6 hrs by multiple response element/cAMP ... |
J Med Chem 55: 250-67 (2012)
Article DOI: 10.1021/jm201150j
BindingDB Entry DOI: 10.7270/Q2M046JC |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Rattus norvegicus) | BDBM50393577
(CHEMBL2158417)Show SMILES COC(=O)[C@@]1(NC(=O)c2ccc(NC(=O)OC(C)(C)C)cc2)[C@H](c2ccc(OC(=O)c3cccs3)c(OC)c2)[C@](NC(=O)c2ccc(NC(=O)OC(C)(C)C)cc2)([C@@H]1c1ccc(OC(=O)c2cccs2)c(OC)c1)C(=O)OC |r,wU:57.62,4.4,22.23,39.42,wD:4.3,39.80,(1.51,-33.71,;3.05,-33.71,;3.82,-35.04,;3.05,-36.38,;5.36,-35.04,;4.59,-33.71,;5.36,-32.37,;6.9,-32.37,;4.59,-31.04,;5.37,-29.71,;4.6,-28.38,;3.05,-28.38,;2.28,-27.05,;3.05,-25.71,;2.28,-24.38,;4.59,-25.71,;5.36,-24.37,;6.9,-24.37,;4.58,-23.04,;6.11,-23.03,;2.29,-29.72,;3.06,-31.05,;5.37,-36.58,;4.57,-37.88,;5.3,-39.22,;4.51,-40.55,;2.96,-40.51,;2.16,-41.83,;2.9,-43.18,;4.44,-43.22,;1.95,-44.4,;.41,-44.35,;-.11,-45.8,;1.1,-46.75,;2.38,-45.88,;2.22,-39.16,;.68,-39.12,;-.05,-37.77,;3.03,-37.85,;6.91,-36.58,;7.97,-37.69,;7.96,-39.23,;6.62,-39.99,;9.29,-40.01,;9.27,-41.55,;10.6,-42.33,;11.94,-41.57,;13.27,-42.35,;13.26,-43.89,;14.59,-44.67,;11.92,-44.65,;11.91,-46.19,;10.57,-46.95,;13.24,-46.97,;11.91,-47.73,;11.95,-40.02,;10.62,-39.25,;6.91,-35.04,;8.23,-34.25,;8.19,-32.71,;9.5,-31.92,;10.86,-32.66,;12.18,-31.87,;12.15,-30.33,;10.8,-29.59,;13.4,-29.43,;14.86,-29.9,;15.77,-28.66,;14.87,-27.41,;13.4,-27.89,;10.88,-34.21,;12.23,-34.95,;13.55,-34.16,;9.56,-35,;8.44,-36.58,;8.96,-35.52,;9.21,-37.91,;10.75,-37.91,)| Show InChI InChI=1S/C56H56N4O16S2/c1-53(2,3)75-51(67)57-35-21-15-31(16-22-35)45(61)59-55(49(65)71-9)43(33-19-25-37(39(29-33)69-7)73-47(63)41-13-11-27-77-41)56(50(66)72-10,60-46(62)32-17-23-36(24-18-32)58-52(68)76-54(4,5)6)44(55)34-20-26-38(40(30-34)70-8)74-48(64)42-14-12-28-78-42/h11-30,43-44H,1-10H3,(H,57,67)(H,58,68)(H,59,61)(H,60,62)/t43-,44+,55+,56- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a |
The National Center for Drug Screening
Curated by ChEMBL
| Assay Description
Agonist activity at rat GLP1R expressed in HEK293 cells assessed as stimulation of cAMP levels incubated for 6 hrs by multiple response element/cAMP ... |
J Med Chem 55: 250-67 (2012)
Article DOI: 10.1021/jm201150j
BindingDB Entry DOI: 10.7270/Q2M046JC |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Rattus norvegicus) | BDBM50393565
(CHEMBL2158391)Show SMILES COc1cccc(c1)[C@H]1[C@@](NC(=O)c2ccc(NC(=O)OC(C)(C)C)cc2)([C@@H](c2cccc(OC)c2)[C@]1(NC(=O)c1ccc(NC(=O)OC(C)(C)C)cc1)C(O)=O)C(O)=O |r,wU:8.8,36.40,27.29,9.10,wD:36.58,9.61,(8.25,-4.56,;6.93,-5.35,;5.58,-4.6,;5.55,-3.06,;4.2,-2.32,;2.88,-3.11,;2.92,-4.65,;4.26,-5.4,;1.6,-5.44,;1.6,-6.98,;2.67,-8.09,;2.66,-9.63,;1.32,-10.39,;3.99,-10.41,;3.97,-11.95,;5.29,-12.73,;6.63,-11.97,;7.96,-12.75,;7.95,-14.29,;9.28,-15.07,;6.61,-15.05,;6.6,-16.59,;5.27,-17.35,;7.93,-17.37,;6.61,-18.13,;6.64,-10.42,;5.31,-9.65,;.06,-6.98,;-.73,-8.27,;-.01,-9.62,;-.8,-10.94,;-2.34,-10.91,;-3.08,-9.56,;-4.62,-9.52,;-5.36,-8.17,;-2.28,-8.24,;.06,-5.44,;-.71,-4.1,;.06,-2.77,;1.6,-2.77,;-.71,-1.44,;.06,-.11,;-.71,1.22,;-2.25,1.22,;-3.02,2.55,;-2.25,3.89,;-3.03,5.22,;-.71,3.89,;.05,5.23,;1.59,5.23,;-.72,6.56,;.81,6.57,;-3.02,-.12,;-2.24,-1.45,;-1.49,-5.44,;-2.26,-4.11,;-2.25,-6.77,;3.13,-6.98,;3.91,-8.31,;3.65,-5.91,)| Show InChI InChI=1S/C44H48N4O12/c1-41(2,3)59-39(55)45-29-19-15-25(16-20-29)35(49)47-43(37(51)52)33(27-11-9-13-31(23-27)57-7)44(38(53)54,34(43)28-12-10-14-32(24-28)58-8)48-36(50)26-17-21-30(22-18-26)46-40(56)60-42(4,5)6/h9-24,33-34H,1-8H3,(H,45,55)(H,46,56)(H,47,49)(H,48,50)(H,51,52)(H,53,54)/t33-,34+,43+,44- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a |
The National Center for Drug Screening
Curated by ChEMBL
| Assay Description
Agonist activity at rat GLP1R expressed in HEK293 cells assessed as stimulation of cAMP levels incubated for 6 hrs by multiple response element/cAMP ... |
J Med Chem 55: 250-67 (2012)
Article DOI: 10.1021/jm201150j
BindingDB Entry DOI: 10.7270/Q2M046JC |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Rattus norvegicus) | BDBM349662
(2-{[4-(6-{[(4-cyano-2-fluorophenyl)(methyl-d2)]oxy...)Show SMILES OC(=O)c1ccc2nc(CN3CCC(CC3)c3cccc(OCc4ccc(cc4F)C#N)n3)n(C[C@@H]3CCO3)c2c1 Show InChI InChI=1S/C31H30FN5O4/c32-25-14-20(16-33)4-5-23(25)19-41-30-3-1-2-26(35-30)21-8-11-36(12-9-21)18-29-34-27-7-6-22(31(38)39)15-28(27)37(29)17-24-10-13-40-24/h1-7,14-15,21,24H,8-13,17-19H2,(H,38,39)/t24-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
PDB
UniChem
| PDB
Article
PubMed
| n/a | n/a | n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01856
BindingDB Entry DOI: 10.7270/Q2736W0V |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Glucagon-like peptide 1 receptor
(Rattus norvegicus) | BDBM50393564
(CHEMBL2158392)Show SMILES CC(C)(C)OC(=O)Nc1ccc(cc1)C(=O)N[C@@]1([C@H](c2ccccc2)[C@](NC(=O)c2ccc(NC(=O)OC(C)(C)C)cc2)([C@@H]1c1ccccc1)C(O)=O)C(O)=O |r,wU:18.19,25.27,43.47,17.17,wD:25.54,17.57,(30.33,-18.46,;31.67,-17.7,;33,-18.48,;31.68,-19.24,;31.68,-16.16,;33.02,-15.4,;34.35,-16.18,;33.03,-13.86,;31.7,-13.08,;30.36,-13.84,;29.03,-13.06,;29.05,-11.52,;30.38,-10.76,;31.71,-11.53,;27.73,-10.74,;26.39,-11.5,;27.74,-9.2,;26.67,-8.09,;26.67,-6.55,;27.99,-5.76,;29.33,-6.51,;30.65,-5.72,;30.62,-4.17,;29.27,-3.43,;27.95,-4.22,;25.13,-6.55,;24.36,-5.22,;25.13,-3.88,;26.67,-3.88,;24.36,-2.55,;25.13,-1.22,;24.36,.11,;22.82,.11,;22.05,1.44,;22.81,2.78,;22.04,4.11,;24.35,2.78,;25.12,4.12,;26.66,4.12,;24.35,5.45,;25.88,5.46,;22.05,-1.23,;22.82,-2.56,;25.13,-8.09,;24.34,-9.39,;22.79,-9.36,;21.99,-10.67,;22.72,-12.02,;24.27,-12.06,;25.06,-10.73,;23.58,-6.55,;22.81,-5.22,;22.81,-7.89,;28.2,-8.09,;28.97,-9.42,;28.72,-7.03,)| Show InChI InChI=1S/C42H44N4O10/c1-39(2,3)55-37(53)43-29-21-17-27(18-22-29)33(47)45-41(35(49)50)31(25-13-9-7-10-14-25)42(36(51)52,32(41)26-15-11-8-12-16-26)46-34(48)28-19-23-30(24-20-28)44-38(54)56-40(4,5)6/h7-24,31-32H,1-6H3,(H,43,53)(H,44,54)(H,45,47)(H,46,48)(H,49,50)(H,51,52)/t31-,32+,41+,42- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a |
The National Center for Drug Screening
Curated by ChEMBL
| Assay Description
Agonist activity at rat GLP1R expressed in HEK293 cells assessed as stimulation of cAMP levels incubated for 6 hrs by multiple response element/cAMP ... |
J Med Chem 55: 250-67 (2012)
Article DOI: 10.1021/jm201150j
BindingDB Entry DOI: 10.7270/Q2M046JC |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Rattus norvegicus) | BDBM50393578
(CHEMBL2158416)Show SMILES COc1cc(ccc1OC(=O)c1cccs1)[C@H]1[C@@](NC(=O)c2ccc(NC(=O)OC(C)(C)C)cc2)([C@@H](c2ccc(OC(=O)c3cccs3)c(OC)c2)[C@]1(NC(=O)c1ccc(NC(=O)OC(C)(C)C)cc1)C(N)=O)C(N)=O |r,wU:35.38,17.19,16.17,52.58,wD:17.79,52.76,(16.51,-8.98,;17.24,-10.33,;18.78,-10.37,;19.58,-9.06,;21.13,-9.09,;21.86,-10.44,;21.07,-11.76,;19.52,-11.73,;18.72,-13.04,;19.46,-14.39,;21,-14.43,;18.51,-15.61,;16.97,-15.57,;16.45,-17.02,;17.66,-17.96,;18.94,-17.09,;21.93,-7.79,;21.92,-6.26,;21.15,-4.92,;21.92,-3.59,;23.46,-3.59,;21.15,-2.25,;21.92,-.93,;21.16,.41,;19.61,.41,;18.84,1.74,;19.61,3.07,;18.84,4.41,;21.15,3.08,;21.92,4.41,;23.46,4.41,;21.14,5.74,;22.67,5.76,;18.84,-.94,;19.62,-2.26,;23.47,-6.25,;24.78,-5.46,;24.75,-3.93,;26.06,-3.13,;27.42,-3.88,;28.74,-3.09,;28.71,-1.55,;27.36,-.8,;29.96,-.64,;31.42,-1.12,;32.33,.13,;31.43,1.37,;29.96,.9,;27.44,-5.42,;28.79,-6.17,;30.11,-5.38,;26.12,-6.21,;23.46,-7.79,;24.53,-8.91,;24.52,-10.45,;23.18,-11.21,;25.85,-11.23,;25.83,-12.76,;27.16,-13.54,;28.5,-12.79,;29.83,-13.56,;29.82,-15.1,;31.14,-15.88,;28.48,-15.87,;28.47,-17.41,;27.13,-18.17,;29.8,-18.18,;28.47,-18.95,;28.5,-11.24,;27.18,-10.46,;25,-7.79,;25.77,-9.13,;25.52,-6.73,;20.38,-6.26,;19.61,-4.92,;19.61,-7.59,)| Show InChI InChI=1S/C54H54N6O14S2/c1-51(2,3)73-49(67)57-33-19-13-29(14-20-33)43(61)59-53(47(55)65)41(31-17-23-35(37(27-31)69-7)71-45(63)39-11-9-25-75-39)54(48(56)66,60-44(62)30-15-21-34(22-16-30)58-50(68)74-52(4,5)6)42(53)32-18-24-36(38(28-32)70-8)72-46(64)40-12-10-26-76-40/h9-28,41-42H,1-8H3,(H2,55,65)(H2,56,66)(H,57,67)(H,58,68)(H,59,61)(H,60,62)/t41-,42+,53+,54- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a |
The National Center for Drug Screening
Curated by ChEMBL
| Assay Description
Agonist activity at rat GLP1R expressed in HEK293 cells assessed as stimulation of cAMP levels incubated for 6 hrs by multiple response element/cAMP ... |
J Med Chem 55: 250-67 (2012)
Article DOI: 10.1021/jm201150j
BindingDB Entry DOI: 10.7270/Q2M046JC |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Rattus norvegicus) | BDBM50393579
(CHEMBL2158415)Show SMILES COc1cc(ccc1OC(=O)c1cccs1)[C@H]1C[C@]1(NC(=O)c1ccc(NC(=O)OC(C)(C)C)cc1)C(O)=O |r| Show InChI InChI=1S/C28H28N2O8S/c1-27(2,3)38-26(35)29-18-10-7-16(8-11-18)23(31)30-28(25(33)34)15-19(28)17-9-12-20(21(14-17)36-4)37-24(32)22-6-5-13-39-22/h5-14,19H,15H2,1-4H3,(H,29,35)(H,30,31)(H,33,34)/t19-,28-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a |
The National Center for Drug Screening
Curated by ChEMBL
| Assay Description
Agonist activity at rat GLP1R expressed in HEK293 cells assessed as stimulation of cAMP levels incubated for 6 hrs by multiple response element/cAMP ... |
J Med Chem 55: 250-67 (2012)
Article DOI: 10.1021/jm201150j
BindingDB Entry DOI: 10.7270/Q2M046JC |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Rattus norvegicus) | BDBM50260246
(1,3-bis(4-(tert-butoxycarbonyl)benzamido)-2,4-bis(...)Show SMILES COc1cc(ccc1OC(=O)c1cccs1)C1C(NC(=O)c2ccc(NC(=O)OC(C)(C)C)cc2)(C(c2ccc(OC(=O)c3cccs3)c(OC)c2)C1(NC(=O)c1ccc(NC(=O)OC(C)(C)C)cc1)C(O)=O)C(O)=O |(.32,-12.51,;1.08,-13.85,;2.62,-13.86,;3.39,-12.53,;4.93,-12.54,;5.69,-13.87,;4.93,-15.19,;3.38,-15.19,;2.61,-16.52,;1.07,-16.52,;.3,-15.18,;.3,-17.85,;-1.23,-18.01,;-1.55,-19.51,;-.22,-20.29,;.93,-19.26,;4.93,-10.99,;4.93,-9.45,;4.92,-7.9,;3.56,-7.14,;2.02,-7.16,;3.56,-5.61,;4.89,-4.84,;4.89,-3.3,;3.55,-2.53,;3.55,-.99,;4.88,-.21,;6.22,-.98,;4.87,1.33,;6.21,2.1,;7.53,2.89,;6.99,.77,;5.43,3.43,;2.22,-3.31,;2.23,-4.85,;6.47,-9.45,;6.46,-7.9,;5.7,-6.57,;6.46,-5.25,;8,-5.24,;8.77,-3.91,;10.31,-3.9,;11.08,-5.24,;11.07,-2.57,;12.6,-2.4,;12.92,-.9,;11.58,-.13,;10.44,-1.16,;8.77,-6.57,;10.31,-6.57,;11.08,-7.91,;8,-7.9,;6.47,-10.99,;6.48,-12.53,;7.83,-13.3,;9.37,-13.29,;7.82,-14.84,;6.48,-15.6,;6.47,-17.14,;7.8,-17.92,;7.8,-19.46,;6.46,-20.22,;5.13,-19.45,;6.45,-21.76,;5.12,-22.53,;3.77,-23.29,;5.88,-23.87,;4.36,-21.19,;9.14,-17.14,;9.15,-15.61,;8.02,-11.01,;8.77,-12.35,;8.8,-9.68,;3.39,-9.44,;2.62,-8.1,;2.61,-10.77,)| Show InChI InChI=1S/C54H52N4O16S2/c1-51(2,3)73-49(67)55-33-19-13-29(14-20-33)43(59)57-53(47(63)64)41(31-17-23-35(37(27-31)69-7)71-45(61)39-11-9-25-75-39)54(48(65)66,58-44(60)30-15-21-34(22-16-30)56-50(68)74-52(4,5)6)42(53)32-18-24-36(38(28-32)70-8)72-46(62)40-12-10-26-76-40/h9-28,41-42H,1-8H3,(H,55,67)(H,56,68)(H,57,59)(H,58,60)(H,63,64)(H,65,66) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PDB
Article
PubMed
| n/a | n/a | n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a |
The National Center for Drug Screening
Curated by ChEMBL
| Assay Description
Agonist activity at rat GLP1R expressed in HEK293 cells assessed as stimulation of cAMP levels incubated for 6 hrs by multiple response element/cAMP ... |
J Med Chem 55: 250-67 (2012)
Article DOI: 10.1021/jm201150j
BindingDB Entry DOI: 10.7270/Q2M046JC |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Glucagon-like peptide 1 receptor
(Rattus norvegicus) | BDBM50393597
(CHEMBL2158394)Show SMILES CCCOc1ccc(cc1)[C@H]1[C@@](NC(=O)c2ccc(NC(=O)OC(C)(C)C)cc2)([C@@H](c2ccc(OCCC)cc2)[C@]1(NC(=O)c1ccc(NC(=O)OC(C)(C)C)cc1)C(O)=O)C(O)=O |r,wU:10.10,40.44,29.31,11.12,wD:40.62,11.65,(34.55,-25.37,;34.58,-26.91,;33.26,-27.7,;33.29,-29.24,;31.97,-30.04,;31.99,-31.58,;30.67,-32.37,;29.33,-31.62,;29.3,-30.08,;30.61,-29.29,;28.02,-32.41,;28.01,-33.95,;29.08,-35.06,;29.07,-36.6,;27.73,-37.36,;30.4,-37.38,;30.38,-38.92,;31.71,-39.7,;33.05,-38.94,;34.38,-39.72,;34.37,-41.26,;35.69,-42.04,;33.03,-42.02,;33.02,-43.56,;31.68,-44.32,;34.35,-44.34,;33.02,-45.1,;33.05,-37.39,;31.73,-36.62,;26.48,-33.95,;25.68,-35.25,;24.13,-35.22,;23.33,-36.53,;24.07,-37.88,;23.27,-39.2,;21.73,-39.16,;20.93,-40.48,;19.39,-40.44,;25.62,-37.92,;26.41,-36.6,;26.47,-32.41,;25.7,-31.08,;26.47,-29.74,;28.01,-29.74,;25.7,-28.41,;26.47,-27.08,;25.71,-25.75,;24.16,-25.75,;23.39,-24.42,;24.16,-23.08,;23.39,-21.75,;25.7,-23.08,;26.47,-21.75,;28.01,-21.74,;25.69,-20.41,;27.22,-20.4,;23.39,-27.09,;24.17,-28.42,;24.93,-32.41,;24.16,-31.08,;24.16,-33.75,;29.55,-33.95,;30.32,-35.28,;30.07,-32.89,)| Show InChI InChI=1S/C48H56N4O12/c1-9-27-61-35-23-15-29(16-24-35)37-47(41(55)56,51-39(53)31-11-19-33(20-12-31)49-43(59)63-45(3,4)5)38(30-17-25-36(26-18-30)62-28-10-2)48(37,42(57)58)52-40(54)32-13-21-34(22-14-32)50-44(60)64-46(6,7)8/h11-26,37-38H,9-10,27-28H2,1-8H3,(H,49,59)(H,50,60)(H,51,53)(H,52,54)(H,55,56)(H,57,58)/t37-,38+,47+,48- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a |
The National Center for Drug Screening
Curated by ChEMBL
| Assay Description
Agonist activity at rat GLP1R expressed in HEK293 cells assessed as stimulation of cAMP levels incubated for 6 hrs by multiple response element/cAMP ... |
J Med Chem 55: 250-67 (2012)
Article DOI: 10.1021/jm201150j
BindingDB Entry DOI: 10.7270/Q2M046JC |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Rattus norvegicus) | BDBM50393596
(CHEMBL2158395)Show SMILES CC(C)(C)OC(=O)Nc1ccc(cc1)C(=O)N[C@@]1([C@H](c2cccc(OCc3ccccc3)c2)[C@](NC(=O)c2ccc(NC(=O)OC(C)(C)C)cc2)([C@@H]1c1cccc(OCc2ccccc2)c1)C(O)=O)C(O)=O |r,wU:18.19,33.36,51.56,17.17,wD:33.72,17.75,(7.25,-16.86,;8.59,-16.1,;9.92,-16.88,;8.59,-17.64,;8.6,-14.56,;9.94,-13.8,;11.26,-14.58,;9.95,-12.26,;8.62,-11.48,;7.28,-12.24,;5.95,-11.46,;5.97,-9.92,;7.3,-9.16,;8.62,-9.93,;4.64,-9.14,;3.3,-9.9,;4.65,-7.6,;3.58,-6.49,;3.59,-4.95,;4.9,-4.16,;4.87,-2.62,;6.18,-1.83,;7.54,-2.57,;7.56,-4.11,;8.91,-4.86,;10.23,-4.07,;11.58,-4.82,;11.59,-6.36,;12.94,-7.1,;14.26,-6.31,;14.23,-4.76,;12.88,-4.02,;6.24,-4.91,;2.04,-4.95,;1.27,-3.61,;2.04,-2.28,;3.58,-2.28,;1.27,-.95,;2.04,.38,;1.28,1.71,;-.27,1.71,;-1.04,3.04,;-.27,4.38,;-1.04,5.71,;1.27,4.38,;2.04,5.72,;3.58,5.72,;1.26,7.05,;2.79,7.06,;-1.04,.37,;-.26,-.96,;2.05,-6.49,;1.25,-7.78,;1.98,-9.13,;1.19,-10.45,;-.36,-10.42,;-1.1,-9.07,;-2.64,-9.03,;-3.37,-7.68,;-4.91,-7.64,;-5.64,-6.29,;-7.18,-6.25,;-7.98,-7.56,;-7.24,-8.92,;-5.7,-8.95,;-.3,-7.75,;.5,-4.95,;-.27,-3.62,;-.27,-6.28,;5.12,-6.49,;5.89,-7.82,;5.64,-5.42,)| Show InChI InChI=1S/C56H56N4O12/c1-53(2,3)71-51(67)57-41-27-23-37(24-28-41)47(61)59-55(49(63)64)45(39-19-13-21-43(31-39)69-33-35-15-9-7-10-16-35)56(50(65)66,46(55)40-20-14-22-44(32-40)70-34-36-17-11-8-12-18-36)60-48(62)38-25-29-42(30-26-38)58-52(68)72-54(4,5)6/h7-32,45-46H,33-34H2,1-6H3,(H,57,67)(H,58,68)(H,59,61)(H,60,62)(H,63,64)(H,65,66)/t45-,46+,55+,56- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a |
The National Center for Drug Screening
Curated by ChEMBL
| Assay Description
Agonist activity at rat GLP1R expressed in HEK293 cells assessed as stimulation of cAMP levels incubated for 6 hrs by multiple response element/cAMP ... |
J Med Chem 55: 250-67 (2012)
Article DOI: 10.1021/jm201150j
BindingDB Entry DOI: 10.7270/Q2M046JC |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Rattus norvegicus) | BDBM50393595
(CHEMBL2158397)Show SMILES COc1cc(ccc1OCc1ccccc1)[C@H]1[C@@](NC(=O)c2ccc(NC(=O)OC(C)(C)C)cc2)([C@@H](c2ccc(OCc3ccccc3)c(OC)c2)[C@]1(NC(=O)c1ccc(NC(=O)OC(C)(C)C)cc1)C(O)=O)C(O)=O |r,wU:35.38,17.19,16.17,52.58,wD:17.79,52.76,(-5.32,-34.94,;-4.58,-36.29,;-3.04,-36.33,;-2.24,-35.02,;-.69,-35.04,;.03,-36.39,;-.76,-37.72,;-2.31,-37.68,;-3.11,-39,;-4.65,-38.96,;-5.45,-40.28,;-6.98,-40.24,;-7.78,-41.55,;-7.05,-42.9,;-5.5,-42.94,;-4.7,-41.62,;.1,-33.75,;.1,-32.21,;-.67,-30.88,;.1,-29.54,;1.64,-29.54,;-.67,-28.21,;.1,-26.88,;-.67,-25.55,;-2.21,-25.55,;-2.98,-24.22,;-2.22,-22.88,;-2.99,-21.55,;-.68,-22.88,;.09,-21.54,;1.63,-21.54,;-.68,-20.21,;.85,-20.2,;-2.98,-26.89,;-2.21,-28.22,;1.64,-32.21,;2.96,-31.42,;2.92,-29.88,;4.24,-29.09,;5.59,-29.83,;6.91,-29.04,;6.88,-27.5,;8.2,-26.71,;9.55,-27.45,;10.87,-26.66,;10.84,-25.12,;9.48,-24.37,;8.17,-25.17,;5.62,-31.38,;6.96,-32.12,;8.29,-31.33,;4.3,-32.17,;1.64,-33.75,;2.71,-34.86,;2.7,-36.4,;1.36,-37.16,;4.02,-37.18,;4.01,-38.72,;5.33,-39.5,;6.67,-38.74,;8,-39.52,;7.99,-41.06,;9.32,-41.84,;6.65,-41.82,;6.64,-43.36,;5.3,-44.12,;7.97,-44.14,;6.65,-44.9,;6.68,-37.19,;5.35,-36.42,;3.17,-33.75,;3.94,-35.08,;3.69,-32.69,;-1.45,-32.21,;-2.22,-30.88,;-2.22,-33.54,)| Show InChI InChI=1S/C58H60N4O14/c1-55(2,3)75-53(69)59-41-25-19-37(20-26-41)49(63)61-57(51(65)66)47(39-23-29-43(45(31-39)71-7)73-33-35-15-11-9-12-16-35)58(52(67)68,62-50(64)38-21-27-42(28-22-38)60-54(70)76-56(4,5)6)48(57)40-24-30-44(46(32-40)72-8)74-34-36-17-13-10-14-18-36/h9-32,47-48H,33-34H2,1-8H3,(H,59,69)(H,60,70)(H,61,63)(H,62,64)(H,65,66)(H,67,68)/t47-,48+,57+,58- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a |
The National Center for Drug Screening
Curated by ChEMBL
| Assay Description
Agonist activity at rat GLP1R expressed in HEK293 cells assessed as stimulation of cAMP levels incubated for 6 hrs by multiple response element/cAMP ... |
J Med Chem 55: 250-67 (2012)
Article DOI: 10.1021/jm201150j
BindingDB Entry DOI: 10.7270/Q2M046JC |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Rattus norvegicus) | BDBM50393594
(CHEMBL2158399)Show SMILES COc1cc(ccc1OCc1ccc(F)cc1)[C@H]1[C@@](NC(=O)c2ccc(NC(=O)OC(C)(C)C)cc2)([C@@H](c2ccc(OCc3ccc(F)cc3)c(OC)c2)[C@]1(NC(=O)c1ccc(NC(=O)OC(C)(C)C)cc1)C(O)=O)C(O)=O |r,wU:36.39,18.20,17.18,54.60,wD:18.81,54.78,(-1.48,-7.62,;-.75,-8.97,;.79,-9.01,;1.59,-7.7,;3.14,-7.73,;3.87,-9.08,;3.08,-10.4,;1.53,-10.37,;.73,-11.68,;-.81,-11.65,;-1.61,-12.96,;-3.15,-12.92,;-3.95,-14.24,;-3.21,-15.59,;-4.01,-16.91,;-1.66,-15.62,;-.87,-14.31,;3.94,-6.43,;3.93,-4.89,;3.16,-3.56,;3.93,-2.23,;5.47,-2.23,;3.16,-.89,;3.93,.43,;3.17,1.77,;1.62,1.77,;.85,3.1,;1.62,4.43,;.85,5.77,;3.16,4.44,;3.93,5.77,;5.47,5.77,;3.15,7.1,;4.68,7.12,;.85,.42,;1.63,-.9,;5.48,-4.89,;6.79,-4.1,;6.76,-2.57,;8.07,-1.77,;9.43,-2.52,;10.75,-1.72,;10.72,-.18,;12.04,.61,;13.38,-.14,;14.7,.66,;14.67,2.2,;15.99,2.99,;13.32,2.94,;12,2.14,;9.45,-4.06,;10.8,-4.81,;12.12,-4.02,;8.13,-4.85,;5.47,-6.43,;6.54,-7.55,;6.53,-9.09,;5.19,-9.85,;7.86,-9.87,;7.84,-11.4,;9.17,-12.18,;10.51,-11.42,;11.84,-12.2,;11.83,-13.74,;13.15,-14.52,;10.49,-14.5,;10.48,-16.04,;9.14,-16.81,;11.81,-16.82,;10.48,-17.59,;10.51,-9.88,;9.19,-9.1,;7.01,-6.43,;7.78,-7.77,;7.53,-5.37,;2.39,-4.9,;1.62,-3.56,;1.62,-6.23,)| Show InChI InChI=1S/C58H58F2N4O14/c1-55(2,3)77-53(71)61-41-23-13-35(14-24-41)49(65)63-57(51(67)68)47(37-17-27-43(45(29-37)73-7)75-31-33-9-19-39(59)20-10-33)58(52(69)70,64-50(66)36-15-25-42(26-16-36)62-54(72)78-56(4,5)6)48(57)38-18-28-44(46(30-38)74-8)76-32-34-11-21-40(60)22-12-34/h9-30,47-48H,31-32H2,1-8H3,(H,61,71)(H,62,72)(H,63,65)(H,64,66)(H,67,68)(H,69,70)/t47-,48+,57+,58- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a |
The National Center for Drug Screening
Curated by ChEMBL
| Assay Description
Agonist activity at rat GLP1R expressed in HEK293 cells assessed as stimulation of cAMP levels incubated for 6 hrs by multiple response element/cAMP ... |
J Med Chem 55: 250-67 (2012)
Article DOI: 10.1021/jm201150j
BindingDB Entry DOI: 10.7270/Q2M046JC |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Rattus norvegicus) | BDBM50393593
(CHEMBL2158400)Show SMILES COc1ccc(cc1OCCCc1ccccc1)[C@H]1[C@@](NC(=O)c2ccc(NC(=O)OC(C)(C)C)cc2)([C@@H](c2ccc(OCCCc3ccccc3)c(OC)c2)[C@]1(NC(=O)c1ccc(NC(=O)OC(C)(C)C)cc1)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C62H68N4O14/c1-59(2,3)79-57(73)63-45-29-23-41(24-30-45)53(67)65-61(55(69)70)51(43-28-34-48(49(37-43)76-8)77-35-15-21-39-17-11-9-12-18-39)62(56(71)72,66-54(68)42-25-31-46(32-26-42)64-58(74)80-60(4,5)6)52(61)44-27-33-47(75-7)50(38-44)78-36-16-22-40-19-13-10-14-20-40/h9-14,17-20,23-34,37-38,51-52H,15-16,21-22,35-36H2,1-8H3,(H,63,73)(H,64,74)(H,65,67)(H,66,68)(H,69,70)(H,71,72)/t51-,52+,61+,62- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a |
The National Center for Drug Screening
Curated by ChEMBL
| Assay Description
Agonist activity at rat GLP1R expressed in HEK293 cells assessed as stimulation of cAMP levels incubated for 6 hrs by multiple response element/cAMP ... |
J Med Chem 55: 250-67 (2012)
Article DOI: 10.1021/jm201150j
BindingDB Entry DOI: 10.7270/Q2M046JC |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Rattus norvegicus) | BDBM50393592
(CHEMBL2158401)Show SMILES COc1cc(ccc1NC(C)=O)[C@H]1[C@@](NC(=O)c2ccc(NC(=O)OC(C)(C)C)cc2)([C@@H](c2ccc(NC(C)=O)c(OC)c2)[C@]1(NC(=O)c1ccc(NC(=O)OC(C)(C)C)cc1)C(O)=O)C(O)=O |r,wU:12.12,44.48,31.33,13.14,wD:44.66,13.69,(8.3,-7.3,;8.28,-5.76,;6.93,-5.02,;5.61,-5.81,;4.27,-5.06,;4.24,-3.52,;5.55,-2.73,;6.91,-3.47,;8.23,-2.68,;9.57,-3.43,;9.6,-4.97,;10.89,-2.63,;2.96,-5.85,;2.95,-7.39,;4.02,-8.5,;4.01,-10.04,;2.67,-10.8,;5.34,-10.82,;5.32,-12.36,;6.65,-13.14,;7.99,-12.38,;9.32,-13.16,;9.31,-14.7,;10.63,-15.48,;7.97,-15.46,;7.96,-17,;6.62,-17.76,;9.29,-17.78,;7.96,-18.54,;7.99,-10.83,;6.67,-10.06,;1.42,-7.39,;.62,-8.69,;1.35,-10.03,;.56,-11.36,;-.99,-11.32,;-1.79,-12.64,;-3.33,-12.6,;-4.07,-11.25,;-4.13,-13.92,;-1.73,-9.97,;-3.27,-9.93,;-4,-8.58,;-.93,-8.66,;1.41,-5.85,;.64,-4.52,;1.41,-3.18,;2.95,-3.18,;.64,-1.85,;1.41,-.52,;.65,.81,;-.9,.81,;-1.67,2.14,;-.9,3.48,;-1.67,4.81,;.64,3.48,;1.41,4.82,;2.95,4.82,;.63,6.15,;2.16,6.16,;-1.67,-.53,;-.89,-1.86,;-.13,-5.85,;-.9,-4.52,;-.9,-7.19,;4.49,-7.39,;5.26,-8.72,;5.01,-6.33,)| Show InChI InChI=1S/C48H54N6O14/c1-25(55)49-33-21-15-29(23-35(33)65-9)37-47(41(59)60,53-39(57)27-11-17-31(18-12-27)51-43(63)67-45(3,4)5)38(30-16-22-34(50-26(2)56)36(24-30)66-10)48(37,42(61)62)54-40(58)28-13-19-32(20-14-28)52-44(64)68-46(6,7)8/h11-24,37-38H,1-10H3,(H,49,55)(H,50,56)(H,51,63)(H,52,64)(H,53,57)(H,54,58)(H,59,60)(H,61,62)/t37-,38+,47+,48- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a |
The National Center for Drug Screening
Curated by ChEMBL
| Assay Description
Agonist activity at rat GLP1R expressed in HEK293 cells assessed as stimulation of cAMP levels incubated for 6 hrs by multiple response element/cAMP ... |
J Med Chem 55: 250-67 (2012)
Article DOI: 10.1021/jm201150j
BindingDB Entry DOI: 10.7270/Q2M046JC |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Rattus norvegicus) | BDBM50393591
(CHEMBL2158402)Show SMILES CC(=O)Nc1ccc(cc1)[C@H]1[C@@](NC(=O)c2ccc(NC(=O)OC(C)(C)C)cc2)([C@@H](c2ccc(NC(C)=O)cc2)[C@]1(NC(=O)c1ccc(NC(=O)OC(C)(C)C)cc1)C(O)=O)C(O)=O |r,wU:10.10,40.44,29.31,11.12,wD:40.62,11.65,(31.93,-5.25,;31.9,-3.71,;33.22,-2.91,;30.56,-2.96,;29.24,-3.75,;29.26,-5.3,;27.94,-6.09,;26.6,-5.34,;26.57,-3.8,;27.88,-3.01,;25.29,-6.13,;25.28,-7.67,;26.35,-8.78,;26.34,-10.32,;25,-11.08,;27.67,-11.1,;27.65,-12.64,;28.98,-13.42,;30.32,-12.66,;31.65,-13.44,;31.64,-14.98,;32.96,-15.76,;30.3,-15.74,;30.29,-17.28,;28.95,-18.04,;31.62,-18.06,;30.29,-18.82,;30.32,-11.11,;29,-10.34,;23.75,-7.67,;22.95,-8.97,;21.4,-8.94,;20.6,-10.25,;21.34,-11.6,;20.54,-12.92,;19,-12.88,;18.26,-11.53,;18.2,-14.2,;22.89,-11.64,;23.68,-10.31,;23.74,-6.13,;22.97,-4.8,;23.74,-3.46,;25.28,-3.46,;22.97,-2.13,;23.74,-.8,;22.98,.53,;21.43,.53,;20.66,1.86,;21.43,3.2,;20.66,4.53,;22.97,3.2,;23.74,4.54,;25.28,4.54,;22.96,5.87,;24.49,5.88,;20.66,-.81,;21.44,-2.14,;22.2,-6.13,;21.43,-4.8,;21.43,-7.47,;26.82,-7.67,;27.59,-9,;27.34,-6.61,)| Show InChI InChI=1S/C46H50N6O12/c1-25(53)47-31-17-9-27(10-18-31)35-45(39(57)58,51-37(55)29-13-21-33(22-14-29)49-41(61)63-43(3,4)5)36(28-11-19-32(20-12-28)48-26(2)54)46(35,40(59)60)52-38(56)30-15-23-34(24-16-30)50-42(62)64-44(6,7)8/h9-24,35-36H,1-8H3,(H,47,53)(H,48,54)(H,49,61)(H,50,62)(H,51,55)(H,52,56)(H,57,58)(H,59,60)/t35-,36+,45+,46- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a |
The National Center for Drug Screening
Curated by ChEMBL
| Assay Description
Agonist activity at rat GLP1R expressed in HEK293 cells assessed as stimulation of cAMP levels incubated for 6 hrs by multiple response element/cAMP ... |
J Med Chem 55: 250-67 (2012)
Article DOI: 10.1021/jm201150j
BindingDB Entry DOI: 10.7270/Q2M046JC |
More data for this
Ligand-Target Pair | |
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