Ki Summary

Reaction Details

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Target

Glucagon-like peptide 1 receptor

Ligand

BDBM50393565

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_855309 (CHEMBL2161793)

EC50

>20000±n/a nM

Citation

Liu, Q; Li, N; Yuan, Y; Lu, H; Wu, X; Zhou, C; He, M; Su, H; Zhang, M; Wang, J; Wang, B; Wang, Y; Ma, D; Ye, Y; Weiss, HC; Gesing, ER; Liao, J; Wang, MW Cyclobutane derivatives as novel nonpeptidic small molecule agonists of glucagon-like peptide-1 receptor. J Med Chem55:250-67 (2012) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Glucagon-like peptide 1 receptor

Name:

Glucagon-like peptide 1 receptor

Synonyms:

GLP1R_RAT | Glp1r | Glpr

Type:

PROTEIN

Mol. Mass.:

52889.73

Organism:

Rattus norvegicus

Description:

ChEMBL_855307

Residue:

463

Sequence:

MAVTPSLLRLALLLLGAVGRAGPRPQGATVSLSETVQKWREYRHQCQRFLTEAPLLATGL
FCNRTFDDYACWPDGPPGSFVNVSCPWYLPWASSVLQGHVYRFCTAEGIWLHKDNSSLPW
RDLSECEESKQGERNSPEEQLLSLYIIYTVGYALSFSALVIASAILVSFRHLHCTRNYIH
LNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLGCRLVFLLMQYCVAAN
YYWLLVEGVYLYTLLAFSVFSEQRIFKLYLSIGWGVPLLFVIPWGIVKYLYEDEGCWTRN
SNMNYWLIIRLPILFAIGVNFLVFIRVICIVIAKLKANLMCKTDIKCRLAKSTLTLIPLL
GTHEVIFAFVMDEHARGTLRFVKLFTELSFTSFQGFMVAVLYCFVNNEVQMEFRKSWERW
RLERLNIQRDSSMKPLKCPTSSVSSGATVGSSVYAATCQNSCS

BDBM50393565

n/a

Name

BDBM50393565

Synonyms:

CHEMBL2158391

Type

Small organic molecule

Emp. Form.

C44H48N4O12

Mol. Mass.

824.8715

SMILES

COc1cccc(c1)[C@H]1[C@@](NC(=O)c2ccc(NC(=O)OC(C)(C)C)cc2)([C@@H](c2cccc(OC)c2)[C@]1(NC(=O)c1ccc(NC(=O)OC(C)(C)C)cc1)C(O)=O)C(O)=O |r,wU:8.8,36.40,27.29,9.10,wD:36.58,9.61,(8.25,-4.56,;6.93,-5.35,;5.58,-4.6,;5.55,-3.06,;4.2,-2.32,;2.88,-3.11,;2.92,-4.65,;4.26,-5.4,;1.6,-5.44,;1.6,-6.98,;2.67,-8.09,;2.66,-9.63,;1.32,-10.39,;3.99,-10.41,;3.97,-11.95,;5.29,-12.73,;6.63,-11.97,;7.96,-12.75,;7.95,-14.29,;9.28,-15.07,;6.61,-15.05,;6.6,-16.59,;5.27,-17.35,;7.93,-17.37,;6.61,-18.13,;6.64,-10.42,;5.31,-9.65,;.06,-6.98,;-.73,-8.27,;-.01,-9.62,;-.8,-10.94,;-2.34,-10.91,;-3.08,-9.56,;-4.62,-9.52,;-5.36,-8.17,;-2.28,-8.24,;.06,-5.44,;-.71,-4.1,;.06,-2.77,;1.6,-2.77,;-.71,-1.44,;.06,-.11,;-.71,1.22,;-2.25,1.22,;-3.02,2.55,;-2.25,3.89,;-3.03,5.22,;-.71,3.89,;.05,5.23,;1.59,5.23,;-.72,6.56,;.81,6.57,;-3.02,-.12,;-2.24,-1.45,;-1.49,-5.44,;-2.26,-4.11,;-2.25,-6.77,;3.13,-6.98,;3.91,-8.31,;3.65,-5.91,)|

Structure