Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tryptophan 2,3-dioxygenase (Mus musculus) | BDBM50289137 (6-Fluoro-3-((E)-2-pyridin-3-yl-vinyl)-1H-indole | ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Namur Curated by ChEMBL | Assay Description Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs... | J Med Chem 54: 5320-34 (2011) Article DOI: 10.1021/jm2006782 BindingDB Entry DOI: 10.7270/Q2RF5W11 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptophan 2,3-dioxygenase (Mus musculus) | BDBM50289138 (3-((E)-2-Pyridin-3-yl-vinyl)-1H-indole | CHEMBL441...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Namur Curated by ChEMBL | Assay Description Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs... | J Med Chem 54: 5320-34 (2011) Article DOI: 10.1021/jm2006782 BindingDB Entry DOI: 10.7270/Q2RF5W11 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptophan 2,3-dioxygenase (Mus musculus) | BDBM50350293 (CHEMBL1812539) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Namur Curated by ChEMBL | Assay Description Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs... | J Med Chem 54: 5320-34 (2011) Article DOI: 10.1021/jm2006782 BindingDB Entry DOI: 10.7270/Q2RF5W11 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptophan 2,3-dioxygenase (Mus musculus) | BDBM50289137 (6-Fluoro-3-((E)-2-pyridin-3-yl-vinyl)-1H-indole | ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.46E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Colorado College Curated by ChEMBL | Assay Description Inhibition of mouse TDO | J Med Chem 58: 8762-82 (2015) Article DOI: 10.1021/acs.jmedchem.5b00461 BindingDB Entry DOI: 10.7270/Q2C82C3F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptophan 2,3-dioxygenase (Mus musculus) | BDBM50350248 (CHEMBL1812545) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.96E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Colorado College Curated by ChEMBL | Assay Description Inhibition of mouse TDO | J Med Chem 58: 8762-82 (2015) Article DOI: 10.1021/acs.jmedchem.5b00461 BindingDB Entry DOI: 10.7270/Q2C82C3F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptophan 2,3-dioxygenase (Mus musculus) | BDBM50350248 (CHEMBL1812545) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Namur Curated by ChEMBL | Assay Description Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs... | J Med Chem 54: 5320-34 (2011) Article DOI: 10.1021/jm2006782 BindingDB Entry DOI: 10.7270/Q2RF5W11 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptophan 2,3-dioxygenase (Mus musculus) | BDBM50350298 (CHEMBL1812546) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Namur Curated by ChEMBL | Assay Description Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs... | J Med Chem 54: 5320-34 (2011) Article DOI: 10.1021/jm2006782 BindingDB Entry DOI: 10.7270/Q2RF5W11 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptophan 2,3-dioxygenase (Mus musculus) | BDBM50350285 (CHEMBL1812531) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Namur Curated by ChEMBL | Assay Description Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs... | J Med Chem 54: 5320-34 (2011) Article DOI: 10.1021/jm2006782 BindingDB Entry DOI: 10.7270/Q2RF5W11 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptophan 2,3-dioxygenase (Mus musculus) | BDBM50350249 (CHEMBL1812547) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Namur Curated by ChEMBL | Assay Description Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs... | J Med Chem 54: 5320-34 (2011) Article DOI: 10.1021/jm2006782 BindingDB Entry DOI: 10.7270/Q2RF5W11 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptophan 2,3-dioxygenase (Mus musculus) | BDBM50350296 (CHEMBL1812543) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Namur Curated by ChEMBL | Assay Description Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs... | J Med Chem 54: 5320-34 (2011) Article DOI: 10.1021/jm2006782 BindingDB Entry DOI: 10.7270/Q2RF5W11 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptophan 2,3-dioxygenase (Mus musculus) | BDBM50350294 (CHEMBL1812540) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Namur Curated by ChEMBL | Assay Description Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs... | J Med Chem 54: 5320-34 (2011) Article DOI: 10.1021/jm2006782 BindingDB Entry DOI: 10.7270/Q2RF5W11 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptophan 2,3-dioxygenase (Mus musculus) | BDBM50289136 (6-Fluoro-3-((E)-2-pyridin-4-yl-vinyl)-1H-indole | ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Namur Curated by ChEMBL | Assay Description Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs... | J Med Chem 54: 5320-34 (2011) Article DOI: 10.1021/jm2006782 BindingDB Entry DOI: 10.7270/Q2RF5W11 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptophan 2,3-dioxygenase (Mus musculus) | BDBM50051818 (CHEMBL3318333) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 4.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Swiss Institute of Bioinformatics Curated by ChEMBL | Assay Description Inhibition of mouse TDO expressed in mouse P815B cells using L-tryptophan substrate incubated for 24 hrs by HPLC based cellular assay | Eur J Med Chem 84: 284-301 (2014) Article DOI: 10.1016/j.ejmech.2014.06.078 BindingDB Entry DOI: 10.7270/Q21C1ZJV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptophan 2,3-dioxygenase (Mus musculus) | BDBM50289140 (5-Fluoro-3-((E)-2-pyridin-3-yl-vinyl)-1H-indole | ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Namur Curated by ChEMBL | Assay Description Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs... | J Med Chem 54: 5320-34 (2011) Article DOI: 10.1021/jm2006782 BindingDB Entry DOI: 10.7270/Q2RF5W11 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptophan 2,3-dioxygenase (Mus musculus) | BDBM32142 (5-amino-8-quinolinol | 5-aminoquinolin-8-ol | 5-az...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Cancer Research Curated by ChEMBL | Assay Description Inhibition of mouse recombinant TDO expressed in mouse P815B cells assessed as blockade of tryptophan degradation by HPLC | J Med Chem 53: 1172-89 (2010) Article DOI: 10.1021/jm9014718 BindingDB Entry DOI: 10.7270/Q2BC40G9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptophan 2,3-dioxygenase (Mus musculus) | BDBM50514753 (CHEMBL4557994) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 5.46E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ del Piemonte Orientale Curated by ChEMBL | Assay Description Inhibition of mouse TDO transfected in P815 cells assessed as reduction in L-Kyn level measured after 16 hrs by HPLC analysis | J Med Chem 63: 3047-3065 (2020) Article DOI: 10.1021/acs.jmedchem.9b01809 BindingDB Entry DOI: 10.7270/Q29K4FKS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptophan 2,3-dioxygenase (Mus musculus) | BDBM50350240 (CHEMBL1812554) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Namur Curated by ChEMBL | Assay Description Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs... | J Med Chem 54: 5320-34 (2011) Article DOI: 10.1021/jm2006782 BindingDB Entry DOI: 10.7270/Q2RF5W11 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptophan 2,3-dioxygenase (Mus musculus) | BDBM50303906 ((E)-4-(isopropylimino)-2-methylnaphthalen-1(4H)-on...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 6.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Cancer Research Curated by ChEMBL | Assay Description Inhibition of mouse recombinant TDO expressed in mouse P815B cells assessed as blockade of tryptophan degradation by HPLC | J Med Chem 53: 1172-89 (2010) Article DOI: 10.1021/jm9014718 BindingDB Entry DOI: 10.7270/Q2BC40G9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptophan 2,3-dioxygenase (Mus musculus) | BDBM50350262 (CHEMBL1812506) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Namur Curated by ChEMBL | Assay Description Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs... | J Med Chem 54: 5320-34 (2011) Article DOI: 10.1021/jm2006782 BindingDB Entry DOI: 10.7270/Q2RF5W11 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptophan 2,3-dioxygenase (Mus musculus) | BDBM50350289 (CHEMBL1812535) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Namur Curated by ChEMBL | Assay Description Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs... | J Med Chem 54: 5320-34 (2011) Article DOI: 10.1021/jm2006782 BindingDB Entry DOI: 10.7270/Q2RF5W11 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptophan 2,3-dioxygenase (Mus musculus) | BDBM50350297 (CHEMBL1812544) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Namur Curated by ChEMBL | Assay Description Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs... | J Med Chem 54: 5320-34 (2011) Article DOI: 10.1021/jm2006782 BindingDB Entry DOI: 10.7270/Q2RF5W11 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptophan 2,3-dioxygenase (Mus musculus) | BDBM50303901 (1,4-Dihydroxynaphthalene | 1,4-Naphthohydroquinone...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Cancer Research Curated by ChEMBL | Assay Description Inhibition of mouse recombinant TDO expressed in mouse P815B cells assessed as blockade of tryptophan degradation by HPLC | J Med Chem 53: 1172-89 (2010) Article DOI: 10.1021/jm9014718 BindingDB Entry DOI: 10.7270/Q2BC40G9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptophan 2,3-dioxygenase (Mus musculus) | BDBM50350292 (CHEMBL1812538) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Namur Curated by ChEMBL | Assay Description Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs... | J Med Chem 54: 5320-34 (2011) Article DOI: 10.1021/jm2006782 BindingDB Entry DOI: 10.7270/Q2RF5W11 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptophan 2,3-dioxygenase (Mus musculus) | BDBM50350308 (CHEMBL1812541) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Namur Curated by ChEMBL | Assay Description Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs... | J Med Chem 54: 5320-34 (2011) Article DOI: 10.1021/jm2006782 BindingDB Entry DOI: 10.7270/Q2RF5W11 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptophan 2,3-dioxygenase (Mus musculus) | BDBM50514760 (CHEMBL4448402) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.32E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ del Piemonte Orientale Curated by ChEMBL | Assay Description Inhibition of mouse TDO transfected in P815 cells assessed as reduction in L-Kyn level measured after 16 hrs by HPLC analysis | J Med Chem 63: 3047-3065 (2020) Article DOI: 10.1021/acs.jmedchem.9b01809 BindingDB Entry DOI: 10.7270/Q29K4FKS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptophan 2,3-dioxygenase (Mus musculus) | BDBM50303903 (4-(Isopropylamino)-1-naphthol | CHEMBL578212) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Cancer Research Curated by ChEMBL | Assay Description Inhibition of mouse recombinant TDO expressed in mouse P815B cells assessed as blockade of tryptophan degradation by HPLC | J Med Chem 53: 1172-89 (2010) Article DOI: 10.1021/jm9014718 BindingDB Entry DOI: 10.7270/Q2BC40G9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptophan 2,3-dioxygenase (Mus musculus) | BDBM50350248 (CHEMBL1812545) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Ludwig Center for Cancer Research of the University of Lausanne Curated by ChEMBL | Assay Description Inhibition of mouse TDO in P815 clone 12 cells by HPLC analysis | J Med Chem 55: 5270-90 (2012) Article DOI: 10.1021/jm300260v BindingDB Entry DOI: 10.7270/Q27H1KNW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptophan 2,3-dioxygenase (Mus musculus) | BDBM50350299 (CHEMBL445966) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Namur Curated by ChEMBL | Assay Description Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs... | J Med Chem 54: 5320-34 (2011) Article DOI: 10.1021/jm2006782 BindingDB Entry DOI: 10.7270/Q2RF5W11 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptophan 2,3-dioxygenase (Mus musculus) | BDBM50350254 (CHEMBL1812498) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Namur Curated by ChEMBL | Assay Description Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs... | J Med Chem 54: 5320-34 (2011) Article DOI: 10.1021/jm2006782 BindingDB Entry DOI: 10.7270/Q2RF5W11 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptophan 2,3-dioxygenase (Mus musculus) | BDBM50350267 (CHEMBL1812512) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Namur Curated by ChEMBL | Assay Description Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs... | J Med Chem 54: 5320-34 (2011) Article DOI: 10.1021/jm2006782 BindingDB Entry DOI: 10.7270/Q2RF5W11 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptophan 2,3-dioxygenase (Mus musculus) | BDBM50350275 (CHEMBL1812520) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Namur Curated by ChEMBL | Assay Description Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs... | J Med Chem 54: 5320-34 (2011) Article DOI: 10.1021/jm2006782 BindingDB Entry DOI: 10.7270/Q2RF5W11 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptophan 2,3-dioxygenase (Mus musculus) | BDBM50350282 (CHEMBL1812528) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Namur Curated by ChEMBL | Assay Description Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs... | J Med Chem 54: 5320-34 (2011) Article DOI: 10.1021/jm2006782 BindingDB Entry DOI: 10.7270/Q2RF5W11 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptophan 2,3-dioxygenase (Mus musculus) | BDBM50289142 (3-((E)-2-Pyridin-4-yl-vinyl)-1H-indole | CHEMBL166...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Namur Curated by ChEMBL | Assay Description Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs... | J Med Chem 54: 5320-34 (2011) Article DOI: 10.1021/jm2006782 BindingDB Entry DOI: 10.7270/Q2RF5W11 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptophan 2,3-dioxygenase (Mus musculus) | BDBM50289139 (3-((E)-2-Pyridin-2-yl-vinyl)-1H-indole | CHEMBL171...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Namur Curated by ChEMBL | Assay Description Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs... | J Med Chem 54: 5320-34 (2011) Article DOI: 10.1021/jm2006782 BindingDB Entry DOI: 10.7270/Q2RF5W11 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptophan 2,3-dioxygenase (Mus musculus) | BDBM50514752 (CHEMBL4458549) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.23E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ del Piemonte Orientale Curated by ChEMBL | Assay Description Inhibition of mouse TDO transfected in P815 cells assessed as reduction in L-Kyn level measured after 16 hrs by HPLC analysis | J Med Chem 63: 3047-3065 (2020) Article DOI: 10.1021/acs.jmedchem.9b01809 BindingDB Entry DOI: 10.7270/Q29K4FKS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptophan 2,3-dioxygenase (Mus musculus) | BDBM50350287 (CHEMBL1812533) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Namur Curated by ChEMBL | Assay Description Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs... | J Med Chem 54: 5320-34 (2011) Article DOI: 10.1021/jm2006782 BindingDB Entry DOI: 10.7270/Q2RF5W11 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptophan 2,3-dioxygenase (Mus musculus) | BDBM50350263 (CHEMBL1812507) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Namur Curated by ChEMBL | Assay Description Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs... | J Med Chem 54: 5320-34 (2011) Article DOI: 10.1021/jm2006782 BindingDB Entry DOI: 10.7270/Q2RF5W11 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptophan 2,3-dioxygenase (Mus musculus) | BDBM50350268 (CHEMBL1812513) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Namur Curated by ChEMBL | Assay Description Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs... | J Med Chem 54: 5320-34 (2011) Article DOI: 10.1021/jm2006782 BindingDB Entry DOI: 10.7270/Q2RF5W11 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptophan 2,3-dioxygenase (Mus musculus) | BDBM50350270 (CHEMBL1812515) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Namur Curated by ChEMBL | Assay Description Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs... | J Med Chem 54: 5320-34 (2011) Article DOI: 10.1021/jm2006782 BindingDB Entry DOI: 10.7270/Q2RF5W11 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptophan 2,3-dioxygenase (Mus musculus) | BDBM50350243 (CHEMBL176991) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Namur Curated by ChEMBL | Assay Description Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs... | J Med Chem 54: 5320-34 (2011) Article DOI: 10.1021/jm2006782 BindingDB Entry DOI: 10.7270/Q2RF5W11 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptophan 2,3-dioxygenase (Mus musculus) | BDBM50303902 (4-(ethylamino)naphthalen-1-ol | CHEMBL577335) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Cancer Research Curated by ChEMBL | Assay Description Inhibition of mouse recombinant TDO expressed in mouse P815B cells assessed as blockade of tryptophan degradation by HPLC | J Med Chem 53: 1172-89 (2010) Article DOI: 10.1021/jm9014718 BindingDB Entry DOI: 10.7270/Q2BC40G9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptophan 2,3-dioxygenase (Mus musculus) | BDBM50303904 ((4E,4'E)-4,4'-bis(isopropylimino)-4',4'a-dihydro-2...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Cancer Research Curated by ChEMBL | Assay Description Inhibition of mouse recombinant TDO expressed in mouse P815B cells assessed as blockade of tryptophan degradation by HPLC | J Med Chem 53: 1172-89 (2010) Article DOI: 10.1021/jm9014718 BindingDB Entry DOI: 10.7270/Q2BC40G9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptophan 2,3-dioxygenase (Mus musculus) | BDBM50303905 ((4E,4'E)-4,4'-bis(pentan-3-ylimino)-4',4'a-dihydro...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Cancer Research Curated by ChEMBL | Assay Description Inhibition of mouse recombinant TDO expressed in mouse P815B cells assessed as blockade of tryptophan degradation by HPLC | J Med Chem 53: 1172-89 (2010) Article DOI: 10.1021/jm9014718 BindingDB Entry DOI: 10.7270/Q2BC40G9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptophan 2,3-dioxygenase (Mus musculus) | BDBM310197 (US10945994, Compound 2a | US9603836, Compound 2a |...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | PDB US Patent | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.; iTEOS THERAPEUTICS US Patent | Assay Description To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb... | US Patent US10945994 (2021) BindingDB Entry DOI: 10.7270/Q25D8W03 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tryptophan 2,3-dioxygenase (Mus musculus) | BDBM309529 (3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione |...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | US Patent | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.; iTEOS THERAPEUTICS US Patent | Assay Description To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb... | US Patent US10945994 (2021) BindingDB Entry DOI: 10.7270/Q25D8W03 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptophan 2,3-dioxygenase (Mus musculus) | BDBM310195 ((-)-(R)-3-(5-fluoro-1H- indol-3-yl)pyrrolidine- 2,...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | US Patent | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.; iTEOS THERAPEUTICS US Patent | Assay Description To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb... | US Patent US10945994 (2021) BindingDB Entry DOI: 10.7270/Q25D8W03 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptophan 2,3-dioxygenase (Mus musculus) | BDBM50350307 (CHEMBL1812526) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Namur Curated by ChEMBL | Assay Description Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs... | J Med Chem 54: 5320-34 (2011) Article DOI: 10.1021/jm2006782 BindingDB Entry DOI: 10.7270/Q2RF5W11 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptophan 2,3-dioxygenase (Mus musculus) | BDBM50300305 (4-Amino-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1,2...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 6.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Ludwig Center for Cancer Research of the University of Lausanne Curated by ChEMBL | Assay Description Inhibition of mouse TDO in P815 clone 12 cells by HPLC analysis | J Med Chem 55: 5270-90 (2012) Article DOI: 10.1021/jm300260v BindingDB Entry DOI: 10.7270/Q27H1KNW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptophan 2,3-dioxygenase (Mus musculus) | BDBM50303910 (4-phenylthiazole-2-thiol | CHEMBL571436) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >8.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Cancer Research Curated by ChEMBL | Assay Description Inhibition of mouse recombinant TDO expressed in mouse P815B cells assessed as blockade of tryptophan degradation by HPLC | J Med Chem 53: 1172-89 (2010) Article DOI: 10.1021/jm9014718 BindingDB Entry DOI: 10.7270/Q2BC40G9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptophan 2,3-dioxygenase (Mus musculus) | BDBM50350247 (CHEMBL1812659) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | >8.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Namur Curated by ChEMBL | Assay Description Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs... | J Med Chem 54: 5320-34 (2011) Article DOI: 10.1021/jm2006782 BindingDB Entry DOI: 10.7270/Q2RF5W11 | |||||||||||
More data for this Ligand-Target Pair |
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