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Compile Data Set for Download or QSAR

Found 315 hits of ki for UniProtKB: P49288   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Melatonin receptor type 1C


(Gallus gallus)
BDBM50470712
PNG
(CHEMBL417988)
Show SMILES COc1ccc2[nH]c(c(CCNC(=O)C(F)(F)F)c2c1)-c1ccccc1
Show InChI InChI=1S/C19H17F3N2O2/c1-26-13-7-8-16-15(11-13)14(9-10-23-18(25)19(20,21)22)17(24-16)12-5-3-2-4-6-12/h2-8,11,24H,9-10H2,1H3,(H,23,25)
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0.0190n/an/an/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Binding affinity in chicken brain membranes by using [2-125I]melatonin in a competition radioligand binding assay


J Med Chem 38: 1132-9 (1995)


Article DOI: 10.1021/jm00007a010
BindingDB Entry DOI: 10.7270/Q2HM5C6M
More data for this
Ligand-Target Pair
Melatonin receptor type 1C


(Gallus gallus)
BDBM50230657
PNG
(CHEMBL290493)
Show SMILES CCCC(=O)NCCc1cccc2ccc(OC)cc12
Show InChI InChI=1S/C17H21NO2/c1-3-5-17(19)18-11-10-14-7-4-6-13-8-9-15(20-2)12-16(13)14/h4,6-9,12H,3,5,10-11H2,1-2H3,(H,18,19)
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0.0295n/an/an/an/an/an/an/an/a



Universit£ de Paris-Sud

Curated by ChEMBL


Assay Description
Binding affinity against chicken brain melatonin receptors using 2-[125I]iodomelatonin as radioligand


J Med Chem 40: 739-48 (1997)


Article DOI: 10.1021/jm960680+
BindingDB Entry DOI: 10.7270/Q2WQ06H4
More data for this
Ligand-Target Pair
Melatonin receptor type 1C


(Gallus gallus)
BDBM29611
PNG
(2-Iodomelatonin | CHEMBL289233 | Melatonin,2-Iodo)
Show SMILES COc1ccc2[nH]c(I)c(CCNC(C)=O)c2c1
Show InChI InChI=1S/C13H15IN2O2/c1-8(17)15-6-5-10-11-7-9(18-2)3-4-12(11)16-13(10)14/h3-4,7,16H,5-6H2,1-2H3,(H,15,17)
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0.0324n/an/an/an/an/an/an/an/a



Universit£ de Paris-Sud

Curated by ChEMBL


Assay Description
Binding affinity against chicken brain melatonin receptors using 2-[125I]iodomelatonin as radioligand


J Med Chem 40: 739-48 (1997)


Article DOI: 10.1021/jm960680+
BindingDB Entry DOI: 10.7270/Q2WQ06H4
More data for this
Ligand-Target Pair
Melatonin receptor type 1C


(Gallus gallus)
BDBM50470694
PNG
(CHEMBL14483)
Show SMILES CCC(=O)NCCc1c([nH]c2ccc(OC)cc12)-c1ccccc1
Show InChI InChI=1S/C20H22N2O2/c1-3-19(23)21-12-11-16-17-13-15(24-2)9-10-18(17)22-20(16)14-7-5-4-6-8-14/h4-10,13,22H,3,11-12H2,1-2H3,(H,21,23)
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0.0466n/an/an/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Binding affinity in chicken brain membranes by using [2-125I]melatonin in a competition radioligand binding assay


J Med Chem 38: 1132-9 (1995)


Article DOI: 10.1021/jm00007a010
BindingDB Entry DOI: 10.7270/Q2HM5C6M
More data for this
Ligand-Target Pair
Melatonin receptor type 1C


(Gallus gallus)
BDBM50470184
PNG
(CHEMBL304203)
Show SMILES COc1ccc2ccc(OC)c(CCNC(=O)C3CC3)c2c1
Show InChI InChI=1S/C18H21NO3/c1-21-14-7-5-12-6-8-17(22-2)15(16(12)11-14)9-10-19-18(20)13-3-4-13/h5-8,11,13H,3-4,9-10H2,1-2H3,(H,19,20)
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0.0500n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Competitive binding by the displacement of 2-[125I]- Iodomelatonin binding from melatonin receptors in chicken brain membranes


J Med Chem 38: 2050-60 (1995)


Article DOI: 10.1021/jm00012a004
BindingDB Entry DOI: 10.7270/Q2ZS307H
More data for this
Ligand-Target Pair
Melatonin receptor type 1C


(Gallus gallus)
BDBM50470711
PNG
(CHEMBL14403)
Show SMILES CCCC(=O)NCCc1c([nH]c2ccc(OC)cc12)-c1ccccc1
Show InChI InChI=1S/C21H24N2O2/c1-3-7-20(24)22-13-12-17-18-14-16(25-2)10-11-19(18)23-21(17)15-8-5-4-6-9-15/h4-6,8-11,14,23H,3,7,12-13H2,1-2H3,(H,22,24)
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0.0558n/an/an/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Binding affinity in chicken brain membranes by using [2-125I]melatonin in a competition radioligand binding assay


J Med Chem 38: 1132-9 (1995)


Article DOI: 10.1021/jm00007a010
BindingDB Entry DOI: 10.7270/Q2HM5C6M
More data for this
Ligand-Target Pair
Melatonin receptor type 1C


(Gallus gallus)
BDBM50034110
PNG
(CHEMBL15060 | Melatonin,2-Phenyl | N-[2-(5-Methoxy...)
Show SMILES COc1ccc2[nH]c(c(CCNC(C)=O)c2c1)-c1ccccc1
Show InChI InChI=1S/C19H20N2O2/c1-13(22)20-11-10-16-17-12-15(23-2)8-9-18(17)21-19(16)14-6-4-3-5-7-14/h3-9,12,21H,10-11H2,1-2H3,(H,20,22)
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0.0596n/an/an/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Binding affinity in chicken brain membranes by using [2-125I]melatonin in a competition radioligand binding assay


J Med Chem 38: 1132-9 (1995)


Article DOI: 10.1021/jm00007a010
BindingDB Entry DOI: 10.7270/Q2HM5C6M
More data for this
Ligand-Target Pair
Melatonin receptor type 1C


(Gallus gallus)
BDBM50035202
PNG
(CHEMBL291857 | N-[2-(2,7-Dimethoxy-naphthalen-1-yl...)
Show SMILES CCC(=O)NCCc1c(OC)ccc2ccc(OC)cc12
Show InChI InChI=1S/C17H21NO3/c1-4-17(19)18-10-9-14-15-11-13(20-2)7-5-12(15)6-8-16(14)21-3/h5-8,11H,4,9-10H2,1-3H3,(H,18,19)
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0.0700n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Competitive binding by the displacement of 2-[125I]- Iodomelatonin binding from melatonin receptors in chicken brain membranes


J Med Chem 38: 2050-60 (1995)


Article DOI: 10.1021/jm00012a004
BindingDB Entry DOI: 10.7270/Q2ZS307H
More data for this
Ligand-Target Pair
Melatonin receptor type 1C


(Gallus gallus)
BDBM50035202
PNG
(CHEMBL291857 | N-[2-(2,7-Dimethoxy-naphthalen-1-yl...)
Show SMILES CCC(=O)NCCc1c(OC)ccc2ccc(OC)cc12
Show InChI InChI=1S/C17H21NO3/c1-4-17(19)18-10-9-14-15-11-13(20-2)7-5-12(15)6-8-16(14)21-3/h5-8,11H,4,9-10H2,1-3H3,(H,18,19)
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0.0724n/an/an/an/an/an/an/an/a



Universit£ de Paris-Sud

Curated by ChEMBL


Assay Description
Binding affinity against chicken brain melatonin receptors using 2-[125I]iodomelatonin as radioligand


J Med Chem 40: 739-48 (1997)


Article DOI: 10.1021/jm960680+
BindingDB Entry DOI: 10.7270/Q2WQ06H4
More data for this
Ligand-Target Pair
Melatonin receptor type 1C


(Gallus gallus)
BDBM50470187
PNG
(CHEMBL428882)
Show SMILES COc1ccc2ccc(OC)c(CCNC(C)=O)c2c1
Show InChI InChI=1S/C16H19NO3/c1-11(18)17-9-8-14-15-10-13(19-2)6-4-12(15)5-7-16(14)20-3/h4-7,10H,8-9H2,1-3H3,(H,17,18)
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0.100n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Competitive binding by the displacement of 2-[125I]- Iodomelatonin binding from melatonin receptors in chicken brain membranes


J Med Chem 38: 2050-60 (1995)


Article DOI: 10.1021/jm00012a004
BindingDB Entry DOI: 10.7270/Q2ZS307H
More data for this
Ligand-Target Pair
Melatonin receptor type 1C


(Gallus gallus)
BDBM50470187
PNG
(CHEMBL428882)
Show SMILES COc1ccc2ccc(OC)c(CCNC(C)=O)c2c1
Show InChI InChI=1S/C16H19NO3/c1-11(18)17-9-8-14-15-10-13(19-2)6-4-12(15)5-7-16(14)20-3/h4-7,10H,8-9H2,1-3H3,(H,17,18)
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0.100n/an/an/an/an/an/an/an/a



Universit£ de Paris-Sud

Curated by ChEMBL


Assay Description
Inhibition of 2-[125I]- iodomelatonin from chicken brain melatonin receptors


J Med Chem 42: 1100-5 (1999)


Article DOI: 10.1021/jm9804937
BindingDB Entry DOI: 10.7270/Q28G8PDM
More data for this
Ligand-Target Pair
Melatonin receptor type 1C


(Gallus gallus)
BDBM50470007
PNG
(CHEMBL322269)
Show SMILES COc1ccc2cccc(CCNC(=O)CBr)c2c1
Show InChI InChI=1S/C15H16BrNO2/c1-19-13-6-5-11-3-2-4-12(14(11)9-13)7-8-17-15(18)10-16/h2-6,9H,7-8,10H2,1H3,(H,17,18)
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0.120n/an/an/an/an/an/an/an/a



Universit£ de Paris-Sud

Curated by ChEMBL


Assay Description
Binding affinity against chicken brain melatonin receptors using 2-[125I]iodomelatonin as radioligand


J Med Chem 40: 739-48 (1997)


Article DOI: 10.1021/jm960680+
BindingDB Entry DOI: 10.7270/Q2WQ06H4
More data for this
Ligand-Target Pair
Melatonin receptor type 1C


(Gallus gallus)
BDBM50470000
PNG
(CHEMBL111599)
Show SMILES CCCC(=O)NCCc1c[nH]c2cc(F)c(OC)cc12
Show InChI InChI=1S/C15H19FN2O2/c1-3-4-15(19)17-6-5-10-9-18-13-8-12(16)14(20-2)7-11(10)13/h7-9,18H,3-6H2,1-2H3,(H,17,19)
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0.141n/an/an/an/an/an/an/an/a



Universit£ de Paris-Sud

Curated by ChEMBL


Assay Description
Binding affinity against chicken brain melatonin receptors using 2-[125I]iodomelatonin as radioligand


J Med Chem 40: 739-48 (1997)


Article DOI: 10.1021/jm960680+
BindingDB Entry DOI: 10.7270/Q2WQ06H4
More data for this
Ligand-Target Pair
Melatonin receptor type 1C


(Gallus gallus)
BDBM50470172
PNG
(CHEMBL294517)
Show SMILES CCC(=O)NCCc1c(OC)ccc2ccccc12
Show InChI InChI=1S/C16H19NO2/c1-3-16(18)17-11-10-14-13-7-5-4-6-12(13)8-9-15(14)19-2/h4-9H,3,10-11H2,1-2H3,(H,17,18)
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0.176n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Effect of compound on Melatonin receptor in chicken brain in the presence of MnCl2


J Med Chem 38: 2050-60 (1995)


Article DOI: 10.1021/jm00012a004
BindingDB Entry DOI: 10.7270/Q2ZS307H
More data for this
Ligand-Target Pair
Melatonin receptor type 1C


(Gallus gallus)
BDBM9019
PNG
(CHEMBL45 | Melatonin | N-[2-(5-methoxy-1H-indol-3-...)
Show SMILES COc1ccc2[nH]cc(CCNC(C)=O)c2c1
Show InChI InChI=1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16)
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0.176n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Effect of compound on Melatonin receptor in chicken brain in the presence of MnCl2


J Med Chem 38: 2050-60 (1995)


Article DOI: 10.1021/jm00012a004
BindingDB Entry DOI: 10.7270/Q2ZS307H
More data for this
Ligand-Target Pair
Melatonin receptor type 1C


(Gallus gallus)
BDBM50408556
PNG
(CHEMBL37771)
Show SMILES CCC(=O)NCCc1cccc2ccc(OC)cc12
Show InChI InChI=1S/C16H19NO2/c1-3-16(18)17-10-9-13-6-4-5-12-7-8-14(19-2)11-15(12)13/h4-8,11H,3,9-10H2,1-2H3,(H,17,18)
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0.182n/an/an/an/an/an/an/an/a



Universit£ de Paris-Sud

Curated by ChEMBL


Assay Description
Binding affinity against chicken brain melatonin receptors using 2-[125I]iodomelatonin as radioligand


J Med Chem 40: 739-48 (1997)


Article DOI: 10.1021/jm960680+
BindingDB Entry DOI: 10.7270/Q2WQ06H4
More data for this
Ligand-Target Pair
Melatonin receptor type 1C


(Gallus gallus)
BDBM50231307
PNG
(CHEMBL34622)
Show SMILES CCC(=O)NCCc1c[nH]c2ccc(OC)cc12
Show InChI InChI=1S/C14H18N2O2/c1-3-14(17)15-7-6-10-9-16-13-5-4-11(18-2)8-12(10)13/h4-5,8-9,16H,3,6-7H2,1-2H3,(H,15,17)
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0.190n/an/an/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Binding affinity towards melatonin receptor in chicken brain.


J Med Chem 39: 1797-805 (1996)


Article DOI: 10.1021/jm9508189
BindingDB Entry DOI: 10.7270/Q29026HC
More data for this
Ligand-Target Pair
Melatonin receptor type 1C


(Gallus gallus)
BDBM50470187
PNG
(CHEMBL428882)
Show SMILES COc1ccc2ccc(OC)c(CCNC(C)=O)c2c1
Show InChI InChI=1S/C16H19NO3/c1-11(18)17-9-8-14-15-10-13(19-2)6-4-12(15)5-7-16(14)20-3/h4-7,10H,8-9H2,1-3H3,(H,17,18)
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0.240n/an/an/an/an/an/an/an/a



Universit£ de Paris-Sud

Curated by ChEMBL


Assay Description
Binding affinity against chicken brain melatonin receptors using 2-[125I]iodomelatonin as radioligand


J Med Chem 40: 739-48 (1997)


Article DOI: 10.1021/jm960680+
BindingDB Entry DOI: 10.7270/Q2WQ06H4
More data for this
Ligand-Target Pair
Melatonin receptor type 1C


(Gallus gallus)
BDBM50469784
PNG
(CHEMBL14975)
Show SMILES COc1ccc2[nH]c(c(CCNC(=O)C3CC3)c2c1)-c1ccccc1
Show InChI InChI=1S/C21H22N2O2/c1-25-16-9-10-19-18(13-16)17(11-12-22-21(24)15-7-8-15)20(23-19)14-5-3-2-4-6-14/h2-6,9-10,13,15,23H,7-8,11-12H2,1H3,(H,22,24)
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0.305n/an/an/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Binding affinity in chicken brain membranes by using [2-125I]melatonin in a competition radioligand binding assay


J Med Chem 38: 1132-9 (1995)


Article DOI: 10.1021/jm00007a010
BindingDB Entry DOI: 10.7270/Q2HM5C6M
More data for this
Ligand-Target Pair
Melatonin receptor type 1C


(Gallus gallus)
BDBM50472142
PNG
(CHEMBL142343)
Show SMILES CCCC(=O)NCC1CCCc2c1c1cc(OC)ccc1n2C
Show InChI InChI=1S/C19H26N2O2/c1-4-6-18(22)20-12-13-7-5-8-17-19(13)15-11-14(23-3)9-10-16(15)21(17)2/h9-11,13H,4-8,12H2,1-3H3,(H,20,22)
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0.378n/an/an/an/an/an/an/an/a



Nantong University

Curated by ChEMBL


Assay Description
Displacement of 2-[125I]iodomelatonin from chick brain melatonin receptor


Eur J Med Chem 185: (2020)


Article DOI: 10.1016/j.ejmech.2019.111847
BindingDB Entry DOI: 10.7270/Q2H70K32
More data for this
Ligand-Target Pair
Melatonin receptor type 1C


(Gallus gallus)
BDBM50212943
PNG
(CHEMBL290895)
Show SMILES CCCC(=O)NC1CCCc2c1c1cc(OC)ccc1n2C
Show InChI InChI=1S/C18H24N2O2/c1-4-6-17(21)19-14-7-5-8-16-18(14)13-11-12(22-3)9-10-15(13)20(16)2/h9-11,14H,4-8H2,1-3H3,(H,19,21)
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0.378n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity towards melatonin receptor was determined using 2-[125I]iodomelatonin as radioligand in chick brain membranes


Citation and Details

BindingDB Entry DOI: 10.7270/Q2CZ39B1
More data for this
Ligand-Target Pair
Melatonin receptor type 1C


(Gallus gallus)
BDBM50472142
PNG
(CHEMBL142343)
Show SMILES CCCC(=O)NCC1CCCc2c1c1cc(OC)ccc1n2C
Show InChI InChI=1S/C19H26N2O2/c1-4-6-18(22)20-12-13-7-5-8-17-19(13)15-11-14(23-3)9-10-16(15)21(17)2/h9-11,13H,4-8,12H2,1-3H3,(H,20,22)
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0.378n/an/an/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Binding affinity towards melatonin receptor, determined in chicken brain membranes using [2-125I]melatonin


J Med Chem 41: 451-67 (1998)


Article DOI: 10.1021/jm970246n
BindingDB Entry DOI: 10.7270/Q2154KSH
More data for this
Ligand-Target Pair
Melatonin receptor type 1C


(Gallus gallus)
BDBM50470180
PNG
(CHEMBL61626)
Show SMILES COc1ccc2ccc(OC)c(CCNC(=O)C(F)(F)F)c2c1
Show InChI InChI=1S/C16H16F3NO3/c1-22-11-5-3-10-4-6-14(23-2)12(13(10)9-11)7-8-20-15(21)16(17,18)19/h3-6,9H,7-8H2,1-2H3,(H,20,21)
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0.389n/an/an/an/an/an/an/an/a



Universit£ de Paris-Sud

Curated by ChEMBL


Assay Description
Binding affinity against chicken brain melatonin receptors using 2-[125I]iodomelatonin as radioligand


J Med Chem 40: 739-48 (1997)


Article DOI: 10.1021/jm960680+
BindingDB Entry DOI: 10.7270/Q2WQ06H4
More data for this
Ligand-Target Pair
Melatonin receptor type 1C


(Gallus gallus)
BDBM50470180
PNG
(CHEMBL61626)
Show SMILES COc1ccc2ccc(OC)c(CCNC(=O)C(F)(F)F)c2c1
Show InChI InChI=1S/C16H16F3NO3/c1-22-11-5-3-10-4-6-14(23-2)12(13(10)9-11)7-8-20-15(21)16(17,18)19/h3-6,9H,7-8H2,1-2H3,(H,20,21)
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0.400n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Competitive binding by the displacement of 2-[125I]- Iodomelatonin binding from melatonin receptors in chicken brain membranes


J Med Chem 38: 2050-60 (1995)


Article DOI: 10.1021/jm00012a004
BindingDB Entry DOI: 10.7270/Q2ZS307H
More data for this
Ligand-Target Pair
Melatonin receptor type 1C


(Gallus gallus)
BDBM9019
PNG
(CHEMBL45 | Melatonin | N-[2-(5-methoxy-1H-indol-3-...)
Show SMILES COc1ccc2[nH]cc(CCNC(C)=O)c2c1
Show InChI InChI=1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16)
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0.460n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
In vitro binding affinity against melatonin receptor using 2-[125I]iodomelatonin (0.05 nM) and chicken brain membranes


J Med Chem 39: 3089-95 (1996)


Article DOI: 10.1021/jm960219h
BindingDB Entry DOI: 10.7270/Q2736TNJ
More data for this
Ligand-Target Pair
Melatonin receptor type 1C


(Gallus gallus)
BDBM50035179
PNG
(Agomelatine | CHEMBL10878 | N-[2-(7-Methoxy-naphth...)
Show SMILES COc1ccc2cccc(CCNC(C)=O)c2c1
Show InChI InChI=1S/C15H17NO2/c1-11(17)16-9-8-13-5-3-4-12-6-7-14(18-2)10-15(12)13/h3-7,10H,8-9H2,1-2H3,(H,16,17)
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0.537n/an/an/an/an/an/an/an/a



Universit£ de Paris-Sud

Curated by ChEMBL


Assay Description
Binding affinity against chicken brain melatonin receptors using 2-[125I]iodomelatonin as radioligand


J Med Chem 40: 739-48 (1997)


Article DOI: 10.1021/jm960680+
BindingDB Entry DOI: 10.7270/Q2WQ06H4
More data for this
Ligand-Target Pair
Melatonin receptor type 1C


(Gallus gallus)
BDBM50035179
PNG
(Agomelatine | CHEMBL10878 | N-[2-(7-Methoxy-naphth...)
Show SMILES COc1ccc2cccc(CCNC(C)=O)c2c1
Show InChI InChI=1S/C15H17NO2/c1-11(17)16-9-8-13-5-3-4-12-6-7-14(18-2)10-15(12)13/h3-7,10H,8-9H2,1-2H3,(H,16,17)
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0.540n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Competitive binding by the displacement of 2-[125I]- Iodomelatonin binding from melatonin receptors in chicken brain membranes


J Med Chem 38: 2050-60 (1995)


Article DOI: 10.1021/jm00012a004
BindingDB Entry DOI: 10.7270/Q2ZS307H
More data for this
Ligand-Target Pair
Melatonin receptor type 1C


(Gallus gallus)
BDBM50470174
PNG
(CHEMBL62992)
Show SMILES COc1ccc2ccccc2c1CCNC(=O)C(F)(F)F
Show InChI InChI=1S/C15H14F3NO2/c1-21-13-7-6-10-4-2-3-5-11(10)12(13)8-9-19-14(20)15(16,17)18/h2-7H,8-9H2,1H3,(H,19,20)
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0.540n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Competitive binding by the displacement of 2-[125I]- Iodomelatonin binding from melatonin receptors in chicken brain membranes


J Med Chem 38: 2050-60 (1995)


Article DOI: 10.1021/jm00012a004
BindingDB Entry DOI: 10.7270/Q2ZS307H
More data for this
Ligand-Target Pair
Melatonin receptor type 1C


(Gallus gallus)
BDBM50035179
PNG
(Agomelatine | CHEMBL10878 | N-[2-(7-Methoxy-naphth...)
Show SMILES COc1ccc2cccc(CCNC(C)=O)c2c1
Show InChI InChI=1S/C15H17NO2/c1-11(17)16-9-8-13-5-3-4-12-6-7-14(18-2)10-15(12)13/h3-7,10H,8-9H2,1-2H3,(H,16,17)
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0.540n/an/an/an/an/an/an/an/a



Universit£ de Paris-Sud

Curated by ChEMBL


Assay Description
Inhibition of 2-[125I]- iodomelatonin from chicken brain melatonin receptors


J Med Chem 42: 1100-5 (1999)


Article DOI: 10.1021/jm9804937
BindingDB Entry DOI: 10.7270/Q28G8PDM
More data for this
Ligand-Target Pair
Melatonin receptor type 1C


(Gallus gallus)
BDBM50470174
PNG
(CHEMBL62992)
Show SMILES COc1ccc2ccccc2c1CCNC(=O)C(F)(F)F
Show InChI InChI=1S/C15H14F3NO2/c1-21-13-7-6-10-4-2-3-5-11(10)12(13)8-9-19-14(20)15(16,17)18/h2-7H,8-9H2,1H3,(H,19,20)
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0.550n/an/an/an/an/an/an/an/a



Universit£ de Paris-Sud

Curated by ChEMBL


Assay Description
Binding affinity against chicken brain melatonin receptors using 2-[125I]iodomelatonin as radioligand


J Med Chem 40: 739-48 (1997)


Article DOI: 10.1021/jm960680+
BindingDB Entry DOI: 10.7270/Q2WQ06H4
More data for this
Ligand-Target Pair
Melatonin receptor type 1C


(Gallus gallus)
BDBM9019
PNG
(CHEMBL45 | Melatonin | N-[2-(5-methoxy-1H-indol-3-...)
Show SMILES COc1ccc2[nH]cc(CCNC(C)=O)c2c1
Show InChI InChI=1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16)
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0.590n/an/an/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Binding affinity towards melatonin receptor, determined in chicken brain membranes using [2-125I]melatonin


J Med Chem 41: 451-67 (1998)


Article DOI: 10.1021/jm970246n
BindingDB Entry DOI: 10.7270/Q2154KSH
More data for this
Ligand-Target Pair
Melatonin receptor type 1C


(Gallus gallus)
BDBM9019
PNG
(CHEMBL45 | Melatonin | N-[2-(5-methoxy-1H-indol-3-...)
Show SMILES COc1ccc2[nH]cc(CCNC(C)=O)c2c1
Show InChI InChI=1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16)
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0.590n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity towards melatonin receptor using 2-[125I]iodomelatonin as radioligand in chick brain membranes


Citation and Details

BindingDB Entry DOI: 10.7270/Q2HQ422R
More data for this
Ligand-Target Pair
Melatonin receptor type 1C


(Gallus gallus)
BDBM9019
PNG
(CHEMBL45 | Melatonin | N-[2-(5-methoxy-1H-indol-3-...)
Show SMILES COc1ccc2[nH]cc(CCNC(C)=O)c2c1
Show InChI InChI=1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16)
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0.590n/an/an/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Binding affinity in chicken brain membranes by using [2-125I]melatonin in a competition radioligand binding assay


J Med Chem 38: 1132-9 (1995)


Article DOI: 10.1021/jm00007a010
BindingDB Entry DOI: 10.7270/Q2HM5C6M
More data for this
Ligand-Target Pair
Melatonin receptor type 1C


(Gallus gallus)
BDBM9019
PNG
(CHEMBL45 | Melatonin | N-[2-(5-methoxy-1H-indol-3-...)
Show SMILES COc1ccc2[nH]cc(CCNC(C)=O)c2c1
Show InChI InChI=1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16)
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0.590n/an/an/an/an/an/an/an/a



Nantong University

Curated by ChEMBL


Assay Description
Displacement of 2-[125I]iodomelatonin from chick brain melatonin receptor


Eur J Med Chem 185: (2020)


Article DOI: 10.1016/j.ejmech.2019.111847
BindingDB Entry DOI: 10.7270/Q2H70K32
More data for this
Ligand-Target Pair
Melatonin receptor type 1C


(Gallus gallus)
BDBM9019
PNG
(CHEMBL45 | Melatonin | N-[2-(5-methoxy-1H-indol-3-...)
Show SMILES COc1ccc2[nH]cc(CCNC(C)=O)c2c1
Show InChI InChI=1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16)
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0.590n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity towards melatonin receptor was determined using 2-[125I]iodomelatonin as radioligand in chick brain membranes


Citation and Details

BindingDB Entry DOI: 10.7270/Q2CZ39B1
More data for this
Ligand-Target Pair
Melatonin receptor type 1C


(Gallus gallus)
BDBM9019
PNG
(CHEMBL45 | Melatonin | N-[2-(5-methoxy-1H-indol-3-...)
Show SMILES COc1ccc2[nH]cc(CCNC(C)=O)c2c1
Show InChI InChI=1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16)
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0.590n/an/an/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Binding affinity towards melatonin receptor in chicken brain.


J Med Chem 39: 1797-805 (1996)


Article DOI: 10.1021/jm9508189
BindingDB Entry DOI: 10.7270/Q29026HC
More data for this
Ligand-Target Pair
Melatonin receptor type 1C


(Gallus gallus)
BDBM9019
PNG
(CHEMBL45 | Melatonin | N-[2-(5-methoxy-1H-indol-3-...)
Show SMILES COc1ccc2[nH]cc(CCNC(C)=O)c2c1
Show InChI InChI=1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16)
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0.670n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Competitive binding by the displacement of 2-[125I]- Iodomelatonin binding from melatonin receptors in chicken brain membranes


J Med Chem 38: 2050-60 (1995)


Article DOI: 10.1021/jm00012a004
BindingDB Entry DOI: 10.7270/Q2ZS307H
More data for this
Ligand-Target Pair
Melatonin receptor type 1C


(Gallus gallus)
BDBM50470172
PNG
(CHEMBL294517)
Show SMILES CCC(=O)NCCc1c(OC)ccc2ccccc12
Show InChI InChI=1S/C16H19NO2/c1-3-16(18)17-11-10-14-13-7-5-4-6-12(13)8-9-15(14)19-2/h4-9H,3,10-11H2,1-2H3,(H,17,18)
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0.676n/an/an/an/an/an/an/an/a



Universit£ de Paris-Sud

Curated by ChEMBL


Assay Description
Binding affinity against chicken brain melatonin receptors using 2-[125I]iodomelatonin as radioligand


J Med Chem 40: 739-48 (1997)


Article DOI: 10.1021/jm960680+
BindingDB Entry DOI: 10.7270/Q2WQ06H4
More data for this
Ligand-Target Pair
Melatonin receptor type 1C


(Gallus gallus)
BDBM9019
PNG
(CHEMBL45 | Melatonin | N-[2-(5-methoxy-1H-indol-3-...)
Show SMILES COc1ccc2[nH]cc(CCNC(C)=O)c2c1
Show InChI InChI=1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16)
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0.676n/an/an/an/an/an/an/an/a



Universit£ de Paris-Sud

Curated by ChEMBL


Assay Description
Binding affinity against chicken brain melatonin receptors using 2-[125I]iodomelatonin as radioligand


J Med Chem 40: 739-48 (1997)


Article DOI: 10.1021/jm960680+
BindingDB Entry DOI: 10.7270/Q2WQ06H4
More data for this
Ligand-Target Pair
Melatonin receptor type 1C


(Gallus gallus)
BDBM50470172
PNG
(CHEMBL294517)
Show SMILES CCC(=O)NCCc1c(OC)ccc2ccccc12
Show InChI InChI=1S/C16H19NO2/c1-3-16(18)17-11-10-14-13-7-5-4-6-12(13)8-9-15(14)19-2/h4-9H,3,10-11H2,1-2H3,(H,17,18)
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0.680n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Competitive binding by the displacement of 2-[125I]- Iodomelatonin binding from melatonin receptors in chicken brain membranes


J Med Chem 38: 2050-60 (1995)


Article DOI: 10.1021/jm00012a004
BindingDB Entry DOI: 10.7270/Q2ZS307H
More data for this
Ligand-Target Pair
Melatonin receptor type 1C


(Gallus gallus)
BDBM50470867
PNG
(CHEMBL318179)
Show SMILES COc1ccc2ccc(OC)c3CC(Cc1c23)NC(C)=O
Show InChI InChI=1S/C17H19NO3/c1-10(19)18-12-8-13-15(20-2)6-4-11-5-7-16(21-3)14(9-12)17(11)13/h4-7,12H,8-9H2,1-3H3,(H,18,19)
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0.700n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
In vitro binding affinity against melatonin receptor using 2-[125I]iodomelatonin (0.05 nM) and chicken brain membranes


J Med Chem 39: 3089-95 (1996)


Article DOI: 10.1021/jm960219h
BindingDB Entry DOI: 10.7270/Q2736TNJ
More data for this
Ligand-Target Pair
Melatonin receptor type 1C


(Gallus gallus)
BDBM9019
PNG
(CHEMBL45 | Melatonin | N-[2-(5-methoxy-1H-indol-3-...)
Show SMILES COc1ccc2[nH]cc(CCNC(C)=O)c2c1
Show InChI InChI=1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16)
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0.700n/an/an/an/an/an/an/an/a



Universit£ de Paris-Sud

Curated by ChEMBL


Assay Description
Inhibition of 2-[125I]- iodomelatonin from chicken brain melatonin receptors


J Med Chem 42: 1100-5 (1999)


Article DOI: 10.1021/jm9804937
BindingDB Entry DOI: 10.7270/Q28G8PDM
More data for this
Ligand-Target Pair
Melatonin receptor type 1C


(Gallus gallus)
BDBM50471024
PNG
(CHEMBL53824)
Show SMILES COc1ccc2n(C)c3CCCC(CNC(C)=O)c3c2c1
Show InChI InChI=1S/C17H22N2O2/c1-11(20)18-10-12-5-4-6-16-17(12)14-9-13(21-3)7-8-15(14)19(16)2/h7-9,12H,4-6,10H2,1-3H3,(H,18,20)
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0.970n/an/an/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Binding affinity towards melatonin receptor in chicken brain.


J Med Chem 39: 1797-805 (1996)


Article DOI: 10.1021/jm9508189
BindingDB Entry DOI: 10.7270/Q29026HC
More data for this
Ligand-Target Pair
Melatonin receptor type 1C


(Gallus gallus)
BDBM50471024
PNG
(CHEMBL53824)
Show SMILES COc1ccc2n(C)c3CCCC(CNC(C)=O)c3c2c1
Show InChI InChI=1S/C17H22N2O2/c1-11(20)18-10-12-5-4-6-16-17(12)14-9-13(21-3)7-8-15(14)19(16)2/h7-9,12H,4-6,10H2,1-3H3,(H,18,20)
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0.970n/an/an/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Binding affinity towards melatonin receptor, determined in chicken brain membranes using [2-125I]melatonin


J Med Chem 41: 451-67 (1998)


Article DOI: 10.1021/jm970246n
BindingDB Entry DOI: 10.7270/Q2154KSH
More data for this
Ligand-Target Pair
Melatonin receptor type 1C


(Gallus gallus)
BDBM50471024
PNG
(CHEMBL53824)
Show SMILES COc1ccc2n(C)c3CCCC(CNC(C)=O)c3c2c1
Show InChI InChI=1S/C17H22N2O2/c1-11(20)18-10-12-5-4-6-16-17(12)14-9-13(21-3)7-8-15(14)19(16)2/h7-9,12H,4-6,10H2,1-3H3,(H,18,20)
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0.970n/an/an/an/an/an/an/an/a



University College London

Curated by ChEMBL


Assay Description
Binding affinity towards melatonin receptor, determined in chicken brain membranes using [2-125I]melatonin


J Med Chem 41: 451-67 (1998)


Article DOI: 10.1021/jm970246n
BindingDB Entry DOI: 10.7270/Q2154KSH
More data for this
Ligand-Target Pair
Melatonin receptor type 1C


(Gallus gallus)
BDBM50282765
PNG
(CHEMBL38728 | N-(6-Methoxy-9-methyl-2,3,4,9-tetrah...)
Show SMILES COc1ccc2n(C)c3CCCC(NC(C)=O)c3c2c1
Show InChI InChI=1S/C16H20N2O2/c1-10(19)17-13-5-4-6-15-16(13)12-9-11(20-3)7-8-14(12)18(15)2/h7-9,13H,4-6H2,1-3H3,(H,17,19)
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0.970n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity towards melatonin receptor was determined using 2-[125I]iodomelatonin as radioligand in chick brain membranes


Citation and Details

BindingDB Entry DOI: 10.7270/Q2CZ39B1
More data for this
Ligand-Target Pair
Melatonin receptor type 1C


(Gallus gallus)
BDBM9019
PNG
(CHEMBL45 | Melatonin | N-[2-(5-methoxy-1H-indol-3-...)
Show SMILES COc1ccc2[nH]cc(CCNC(C)=O)c2c1
Show InChI InChI=1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16)
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1.10n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Effect of compound on Melatonin receptor in chicken brain in the presence of GTP-gamma-S


J Med Chem 38: 2050-60 (1995)


Article DOI: 10.1021/jm00012a004
BindingDB Entry DOI: 10.7270/Q2ZS307H
More data for this
Ligand-Target Pair
Melatonin receptor type 1C


(Gallus gallus)
BDBM50470183
PNG
(CHEMBL305383)
Show SMILES CCC(=O)NCCc1cc(Br)ccc1OC
Show InChI InChI=1S/C12H16BrNO2/c1-3-12(15)14-7-6-9-8-10(13)4-5-11(9)16-2/h4-5,8H,3,6-7H2,1-2H3,(H,14,15)
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1.10n/an/an/an/an/an/an/an/a



Universit£ de Paris-Sud

Curated by ChEMBL


Assay Description
Binding affinity against chicken brain melatonin receptors using 2-[125I]iodomelatonin as radioligand


J Med Chem 40: 739-48 (1997)


Article DOI: 10.1021/jm960680+
BindingDB Entry DOI: 10.7270/Q2WQ06H4
More data for this
Ligand-Target Pair
Melatonin receptor type 1C


(Gallus gallus)
BDBM50471087
PNG
(CHEMBL124462)
Show SMILES CCOc1ccc2ccccc2c1CCNC(=O)CC
Show InChI InChI=1S/C17H21NO2/c1-3-17(19)18-12-11-15-14-8-6-5-7-13(14)9-10-16(15)20-4-2/h5-10H,3-4,11-12H2,1-2H3,(H,18,19)
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1.10n/an/an/an/an/an/an/an/a



Universit£ de Paris-Sud

Curated by ChEMBL


Assay Description
Binding affinity against chicken brain melatonin receptors using 2-[125I]iodomelatonin as radioligand


J Med Chem 40: 739-48 (1997)


Article DOI: 10.1021/jm960680+
BindingDB Entry DOI: 10.7270/Q2WQ06H4
More data for this
Ligand-Target Pair
Melatonin receptor type 1C


(Gallus gallus)
BDBM50470172
PNG
(CHEMBL294517)
Show SMILES CCC(=O)NCCc1c(OC)ccc2ccccc12
Show InChI InChI=1S/C16H19NO2/c1-3-16(18)17-11-10-14-13-7-5-4-6-12(13)8-9-15(14)19-2/h4-9H,3,10-11H2,1-2H3,(H,17,18)
UniProtKB/SwissProt

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UniChem
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1.10n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Effect of compound on Melatonin receptor in chicken brain in the presence of GTP-gamma-S


J Med Chem 38: 2050-60 (1995)


Article DOI: 10.1021/jm00012a004
BindingDB Entry DOI: 10.7270/Q2ZS307H
More data for this
Ligand-Target Pair
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