Compile Data Set for Download or QSAR

Found 307 hits of ic50 for UniProtKB: P31421   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM212860 (US9278960, 2-7 | US9663506, Example 2-7) Show SMILES NC(=O)c1cc(-c2ccc(F)cc2)c2ccc(CN3C(=O)CCC3=O)cc2n1 Show InChI InChI=1S/C21H16FN3O3/c22-14-4-2-13(3-5-14)16-10-18(21(23)28)24-17-9-12(1-6-15(16)17)11-25-19(26)7-8-20(25)27/h1-6,9-10H,7-8,11H2,(H2,23,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	8.90	n/a	n/a	n/a	n/a	n/a	n/a
Merck & Co. Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGluR2 by FLIPR assay				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.127066 BindingDB Entry DOI: 10.7270/Q2G44TTJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM430158 (4-(2-fluoro-4-methoxyphenyl)-5-((2-methylpyridin-4...) Show SMILES COc1ccc(c(F)c1)-c1cc(ncc1OCc1ccnc(C)c1)C(N)=O Show InChI InChI=1S/C20H18FN3O3/c1-12-7-13(5-6-23-12)11-27-19-10-24-18(20(22)25)9-16(19)15-4-3-14(26-2)8-17(15)21/h3-10H,11H2,1-2H3,(H2,22,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University US Patent					Assay Description Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...				US Patent US10538491 (2020) BindingDB Entry DOI: 10.7270/Q2GT5QKF
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM430113 (4-(2-fluoro-4-methoxyphenyl)-5-(pyridin-3-ylmethox...) Show SMILES COc1ccc(c(F)c1)-c1cc(ncc1OCc1cccnc1)C(N)=O Show InChI InChI=1S/C19H16FN3O3/c1-25-13-4-5-14(16(20)7-13)15-8-17(19(21)24)23-10-18(15)26-11-12-3-2-6-22-9-12/h2-10H,11H2,1H3,(H2,21,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University US Patent					Assay Description Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...				US Patent US10538491 (2020) BindingDB Entry DOI: 10.7270/Q2GT5QKF
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM212860 (US9278960, 2-7 | US9663506, Example 2-7) Show SMILES NC(=O)c1cc(-c2ccc(F)cc2)c2ccc(CN3C(=O)CCC3=O)cc2n1 Show InChI InChI=1S/C21H16FN3O3/c22-14-4-2-13(3-5-14)16-10-18(21(23)28)24-17-9-12(1-6-15(16)17)11-25-19(26)7-8-20(25)27/h1-6,9-10H,7-8,11H2,(H2,23,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	54	n/a	n/a	n/a	n/a	n/a	n/a
Merck & Co. Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGluR2 by GTPgammaS binding assay				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.127066 BindingDB Entry DOI: 10.7270/Q2G44TTJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM430126 (4-(4-fluorophenyl)-5-((1-methyl-1H-pyrazol-3-yl)me...) Show SMILES Cn1ccc(COc2cnc(cc2-c2ccc(F)cc2)C(N)=O)n1 Show InChI InChI=1S/C17H15FN4O2/c1-22-7-6-13(21-22)10-24-16-9-20-15(17(19)23)8-14(16)11-2-4-12(18)5-3-11/h2-9H,10H2,1H3,(H2,19,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	66	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University US Patent					Assay Description Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...				US Patent US10538491 (2020) BindingDB Entry DOI: 10.7270/Q2GT5QKF
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50503469 (CHEMBL4575990) Show SMILES NC(=O)c1cc(-c2ccc(F)cc2)n2nc(CCc3ccnc(c3)C(F)(F)F)cc2n1 Show InChI InChI=1S/C21H15F4N5O/c22-14-4-2-13(3-5-14)17-11-16(20(26)31)28-19-10-15(29-30(17)19)6-1-12-7-8-27-18(9-12)21(23,24)25/h2-5,7-11H,1,6H2,(H2,26,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	87	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50503469 (CHEMBL4575990) Show SMILES NC(=O)c1cc(-c2ccc(F)cc2)n2nc(CCc3ccnc(c3)C(F)(F)F)cc2n1 Show InChI InChI=1S/C21H15F4N5O/c22-14-4-2-13(3-5-14)17-11-16(20(26)31)28-19-10-15(29-30(17)19)6-1-12-7-8-27-18(9-12)21(23,24)25/h2-5,7-11H,1,6H2,(H2,26,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	87	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM430220 (5-((2-cyanobenzyl)oxy)-4-(4-fluorophenyl)picolinam...) Show SMILES NC(=O)c1cc(c(OCc2ccccc2C#N)cn1)-c1ccc(F)cc1 Show InChI InChI=1S/C20H14FN3O2/c21-16-7-5-13(6-8-16)17-9-18(20(23)25)24-11-19(17)26-12-15-4-2-1-3-14(15)10-22/h1-9,11H,12H2,(H2,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	98	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University US Patent					Assay Description Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...				US Patent US10538491 (2020) BindingDB Entry DOI: 10.7270/Q2GT5QKF
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50503465 (CHEMBL4550009) Show SMILES NC(=O)c1cc(-c2ccc(F)cc2F)n2nc(COc3ccnc(c3)C(F)(F)F)cc2n1 Show InChI InChI=1S/C20H12F5N5O2/c21-10-1-2-13(14(22)5-10)16-8-15(19(26)31)28-18-6-11(29-30(16)18)9-32-12-3-4-27-17(7-12)20(23,24)25/h1-8H,9H2,(H2,26,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	102	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50503465 (CHEMBL4550009) Show SMILES NC(=O)c1cc(-c2ccc(F)cc2F)n2nc(COc3ccnc(c3)C(F)(F)F)cc2n1 Show InChI InChI=1S/C20H12F5N5O2/c21-10-1-2-13(14(22)5-10)16-8-15(19(26)31)28-18-6-11(29-30(16)18)9-32-12-3-4-27-17(7-12)20(23,24)25/h1-8H,9H2,(H2,26,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	102	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM430124 (4-(4-fluorophenyl)-5-(imidazo[1,2-a]pyridin-6-ylme...) Show SMILES NC(=O)c1cc(c(OCc2ccc3nccn3c2)cn1)-c1ccc(F)cc1 Show InChI InChI=1S/C20H15FN4O2/c21-15-4-2-14(3-5-15)16-9-17(20(22)26)24-10-18(16)27-12-13-1-6-19-23-7-8-25(19)11-13/h1-11H,12H2,(H2,22,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	129	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University US Patent					Assay Description Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...				US Patent US10538491 (2020) BindingDB Entry DOI: 10.7270/Q2GT5QKF
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50503466 (CHEMBL4569114) Show SMILES COc1ccc(c(F)c1)-c1cc(nc2cc(COc3ccnc(c3)C(F)(F)F)nn12)C(N)=O Show InChI InChI=1S/C21H15F4N5O3/c1-32-12-2-3-14(15(22)7-12)17-9-16(20(26)31)28-19-6-11(29-30(17)19)10-33-13-4-5-27-18(8-13)21(23,24)25/h2-9H,10H2,1H3,(H2,26,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	148	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50503466 (CHEMBL4569114) Show SMILES COc1ccc(c(F)c1)-c1cc(nc2cc(COc3ccnc(c3)C(F)(F)F)nn12)C(N)=O Show InChI InChI=1S/C21H15F4N5O3/c1-32-12-2-3-14(15(22)7-12)17-9-16(20(26)31)28-19-6-11(29-30(17)19)10-33-13-4-5-27-18(8-13)21(23,24)25/h2-9H,10H2,1H3,(H2,26,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	148	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM430119 (4-(4-fluorophenyl)-5-((2-methylpyridin-4-yl)methox...) Show SMILES Cc1cc(COc2cnc(cc2-c2ccc(F)cc2)C(N)=O)ccn1 Show InChI InChI=1S/C19H16FN3O2/c1-12-8-13(6-7-22-12)11-25-18-10-23-17(19(21)24)9-16(18)14-2-4-15(20)5-3-14/h2-10H,11H2,1H3,(H2,21,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	195	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University US Patent					Assay Description Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...				US Patent US10538491 (2020) BindingDB Entry DOI: 10.7270/Q2GT5QKF
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50062522 ((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...) Show SMILES N[C@@](CC1c2ccccc2Oc2ccccc12)([C@H]1C[C@@H]1C(O)=O)C(O)=O Show InChI InChI=1S/C20H19NO5/c21-20(19(24)25,15-9-13(15)18(22)23)10-14-11-5-1-3-7-16(11)26-17-8-4-2-6-12(14)17/h1-8,13-15H,9-10,21H2,(H,22,23)(H,24,25)/t13-,15-,20-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PDB PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Centro de Investigación Lilly, SA Curated by ChEMBL					Assay Description Antagonistic activity against metabotropic glutamate receptor 2 (mGluR2) was evaluated				Bioorg Med Chem Lett 8: 2849-54 (1999) BindingDB Entry DOI: 10.7270/Q2Z0379C
					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM430120 (4-(4-fluorophenyl)-5-((2-methoxypyridin-4-yl)metho...) Show SMILES COc1cc(COc2cnc(cc2-c2ccc(F)cc2)C(N)=O)ccn1 Show InChI InChI=1S/C19H16FN3O3/c1-25-18-8-12(6-7-22-18)11-26-17-10-23-16(19(21)24)9-15(17)13-2-4-14(20)5-3-13/h2-10H,11H2,1H3,(H2,21,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	204	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University US Patent					Assay Description Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...				US Patent US10538491 (2020) BindingDB Entry DOI: 10.7270/Q2GT5QKF
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM430153 (4-(2-fluoro-4-methoxyphenyl)-5-((6- methylpyridin-...) Show SMILES COc1ccc(c(F)c1)-c1cc(ncc1OCc1ccc(C)nc1)C(N)=O Show InChI InChI=1S/C20H18FN3O3/c1-12-3-4-13(9-23-12)11-27-19-10-24-18(20(22)25)8-16(19)15-6-5-14(26-2)7-17(15)21/h3-10H,11H2,1-2H3,(H2,22,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	216	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University US Patent					Assay Description Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...				US Patent US10538491 (2020) BindingDB Entry DOI: 10.7270/Q2GT5QKF
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50503467 (CHEMBL4533083) Show SMILES NC(=O)c1cc(-c2ccc(F)cc2)n2nc(COc3ccnc(Br)c3)cc2n1 Show InChI InChI=1S/C19H13BrFN5O2/c20-17-8-14(5-6-23-17)28-10-13-7-18-24-15(19(22)27)9-16(26(18)25-13)11-1-3-12(21)4-2-11/h1-9H,10H2,(H2,22,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	224	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50503467 (CHEMBL4533083) Show SMILES NC(=O)c1cc(-c2ccc(F)cc2)n2nc(COc3ccnc(Br)c3)cc2n1 Show InChI InChI=1S/C19H13BrFN5O2/c20-17-8-14(5-6-23-17)28-10-13-7-18-24-15(19(22)27)9-16(26(18)25-13)11-1-3-12(21)4-2-11/h1-9H,10H2,(H2,22,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	224	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM430118 (4-(4-fluorophenyl)-5-(pyridin-4-ylmethoxy)picolina...) Show SMILES NC(=O)c1cc(c(OCc2ccncc2)cn1)-c1ccc(F)cc1 Show InChI InChI=1S/C18H14FN3O2/c19-14-3-1-13(2-4-14)15-9-16(18(20)23)22-10-17(15)24-11-12-5-7-21-8-6-12/h1-10H,11H2,(H2,20,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	239	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University US Patent					Assay Description Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...				US Patent US10538491 (2020) BindingDB Entry DOI: 10.7270/Q2GT5QKF
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM430186 (4-(4-fluorophenyl)-5-(2-((2-(trifluoromethyl)pyrid...) Show SMILES NC(=O)c1cc(c(OCCOc2ccnc(c2)C(F)(F)F)cn1)-c1ccc(F)cc1 Show InChI InChI=1S/C20H15F4N3O3/c21-13-3-1-12(2-4-13)15-10-16(19(25)28)27-11-17(15)30-8-7-29-14-5-6-26-18(9-14)20(22,23)24/h1-6,9-11H,7-8H2,(H2,25,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	242	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University US Patent					Assay Description Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...				US Patent US10538491 (2020) BindingDB Entry DOI: 10.7270/Q2GT5QKF
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM430219 (5-((3-cyano-2-fluorobenzyl)oxy)-4-(4-fluorophenyl)...) Show SMILES NC(=O)c1cc(c(OCc2cccc(C#N)c2F)cn1)-c1ccc(F)cc1 Show InChI InChI=1S/C20H13F2N3O2/c21-15-6-4-12(5-7-15)16-8-17(20(24)26)25-10-18(16)27-11-14-3-1-2-13(9-23)19(14)22/h1-8,10H,11H2,(H2,24,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	254	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University US Patent					Assay Description Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...				US Patent US10538491 (2020) BindingDB Entry DOI: 10.7270/Q2GT5QKF
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM430125 (4-(4-fluorophenyl)-5-( thiazol-5-ylmethoxy)picolin...) Show SMILES NC(=O)c1cc(c(OCc2cncs2)cn1)-c1ccc(F)cc1 Show InChI InChI=1S/C16H12FN3O2S/c17-11-3-1-10(2-4-11)13-5-14(16(18)21)20-7-15(13)22-8-12-6-19-9-23-12/h1-7,9H,8H2,(H2,18,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	263	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University US Patent					Assay Description Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...				US Patent US10538491 (2020) BindingDB Entry DOI: 10.7270/Q2GT5QKF
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM430116 (4-(4-fluorophenyl)-5-((6-methoxypyridin-3-yl)metho...) Show SMILES COc1ccc(COc2cnc(cc2-c2ccc(F)cc2)C(N)=O)cn1 Show InChI InChI=1S/C19H16FN3O3/c1-25-18-7-2-12(9-23-18)11-26-17-10-22-16(19(21)24)8-15(17)13-3-5-14(20)6-4-13/h2-10H,11H2,1H3,(H2,21,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	266	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University US Patent					Assay Description Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...				US Patent US10538491 (2020) BindingDB Entry DOI: 10.7270/Q2GT5QKF
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50503464 (CHEMBL4550517) Show SMILES COc1ccc(c(F)c1)-c1cc(nc2cc(COc3ccnc(C)c3)nn12)C(N)=O Show InChI InChI=1S/C21H18FN5O3/c1-12-7-15(5-6-24-12)30-11-13-8-20-25-18(21(23)28)10-19(27(20)26-13)16-4-3-14(29-2)9-17(16)22/h3-10H,11H2,1-2H3,(H2,23,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	288	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50503464 (CHEMBL4550517) Show SMILES COc1ccc(c(F)c1)-c1cc(nc2cc(COc3ccnc(C)c3)nn12)C(N)=O Show InChI InChI=1S/C21H18FN5O3/c1-12-7-15(5-6-24-12)30-11-13-8-20-25-18(21(23)28)10-19(27(20)26-13)16-4-3-14(29-2)9-17(16)22/h3-10H,11H2,1-2H3,(H2,23,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	288	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM430217 (5-((5-cyano-2-fluorobenzyl)oxy)-4-(4-fluorophenyl)...) Show SMILES NC(=O)c1cc(c(OCc2cc(ccc2F)C#N)cn1)-c1ccc(F)cc1 Show InChI InChI=1S/C20H13F2N3O2/c21-15-4-2-13(3-5-15)16-8-18(20(24)26)25-10-19(16)27-11-14-7-12(9-23)1-6-17(14)22/h1-8,10H,11H2,(H2,24,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	313	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University US Patent					Assay Description Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...				US Patent US10538491 (2020) BindingDB Entry DOI: 10.7270/Q2GT5QKF
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50503459 (CHEMBL4475753) Show SMILES COc1ccc(cc1)-c1cc(nc2cc(COc3cnc(C)nc3)sc12)C(N)=O Show InChI InChI=1S/C21H18N4O3S/c1-12-23-9-15(10-24-12)28-11-16-7-18-20(29-16)17(8-19(25-18)21(22)26)13-3-5-14(27-2)6-4-13/h3-10H,11H2,1-2H3,(H2,22,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	316	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50503459 (CHEMBL4475753) Show SMILES COc1ccc(cc1)-c1cc(nc2cc(COc3cnc(C)nc3)sc12)C(N)=O Show InChI InChI=1S/C21H18N4O3S/c1-12-23-9-15(10-24-12)28-11-16-7-18-20(29-16)17(8-19(25-18)21(22)26)13-3-5-14(27-2)6-4-13/h3-10H,11H2,1-2H3,(H2,22,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	316	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM430115 (4-(4-fluorophenyl)-5-((6-methylpyridin-3-yl)methox...) Show SMILES Cc1ccc(COc2cnc(cc2-c2ccc(F)cc2)C(N)=O)cn1 Show InChI InChI=1S/C19H16FN3O2/c1-12-2-3-13(9-22-12)11-25-18-10-23-17(19(21)24)8-16(18)14-4-6-15(20)7-5-14/h2-10H,11H2,1H3,(H2,21,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	343	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University US Patent					Assay Description Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...				US Patent US10538491 (2020) BindingDB Entry DOI: 10.7270/Q2GT5QKF
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50503490 (CHEMBL4549344) Show SMILES COc1ccc(c(F)c1)-c1cc(nc2cc(COc3ccc(nc3)C(F)(F)F)nn12)C(N)=O Show InChI InChI=1S/C21H15F4N5O3/c1-32-12-2-4-14(15(22)7-12)17-8-16(20(26)31)28-19-6-11(29-30(17)19)10-33-13-3-5-18(27-9-13)21(23,24)25/h2-9H,10H2,1H3,(H2,26,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	347	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50503490 (CHEMBL4549344) Show SMILES COc1ccc(c(F)c1)-c1cc(nc2cc(COc3ccc(nc3)C(F)(F)F)nn12)C(N)=O Show InChI InChI=1S/C21H15F4N5O3/c1-32-12-2-4-14(15(22)7-12)17-8-16(20(26)31)28-19-6-11(29-30(17)19)10-33-13-3-5-18(27-9-13)21(23,24)25/h2-9H,10H2,1H3,(H2,26,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	347	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM430105 (5-((3,5-difluorobenzyl)oxy)-4-(2-fluoro-4-methoxyp...) Show SMILES COc1ccc(c(F)c1)-c1cc(ncc1OCc1cc(F)cc(F)c1)C(N)=O Show InChI InChI=1S/C20H15F3N2O3/c1-27-14-2-3-15(17(23)7-14)16-8-18(20(24)26)25-9-19(16)28-10-11-4-12(21)6-13(22)5-11/h2-9H,10H2,1H3,(H2,24,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	395	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University US Patent					Assay Description Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...				US Patent US10538491 (2020) BindingDB Entry DOI: 10.7270/Q2GT5QKF
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM430104 (5-((3,5-difluorobenzyl)oxy)-4-(4-fluorophenyl)pico...) Show SMILES NC(=O)c1cc(c(OCc2cc(F)cc(F)c2)cn1)-c1ccc(F)cc1 Show InChI InChI=1S/C19H13F3N2O2/c20-13-3-1-12(2-4-13)16-8-17(19(23)25)24-9-18(16)26-10-11-5-14(21)7-15(22)6-11/h1-9H,10H2,(H2,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	401	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University US Patent					Assay Description Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...				US Patent US10538491 (2020) BindingDB Entry DOI: 10.7270/Q2GT5QKF
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM430188 (4-(4-fluorophenyl)-5-(2-((2-methylpyridin-4-yl)oxy...) Show SMILES Cc1cc(OCCOc2cnc(cc2-c2ccc(F)cc2)C(N)=O)ccn1 Show InChI InChI=1S/C20H18FN3O3/c1-13-10-16(6-7-23-13)26-8-9-27-19-12-24-18(20(22)25)11-17(19)14-2-4-15(21)5-3-14/h2-7,10-12H,8-9H2,1H3,(H2,22,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	410	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University US Patent					Assay Description Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...				US Patent US10538491 (2020) BindingDB Entry DOI: 10.7270/Q2GT5QKF
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50503480 (CHEMBL4516001) Show SMILES COc1ccc(c(F)c1)-c1cc(nc2cc(COc3cnc(C)nc3)sc12)C(N)=O Show InChI InChI=1S/C21H17FN4O3S/c1-11-24-8-13(9-25-11)29-10-14-6-18-20(30-14)16(7-19(26-18)21(23)27)15-4-3-12(28-2)5-17(15)22/h3-9H,10H2,1-2H3,(H2,23,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	427	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50503480 (CHEMBL4516001) Show SMILES COc1ccc(c(F)c1)-c1cc(nc2cc(COc3cnc(C)nc3)sc12)C(N)=O Show InChI InChI=1S/C21H17FN4O3S/c1-11-24-8-13(9-25-11)29-10-14-6-18-20(30-14)16(7-19(26-18)21(23)27)15-4-3-12(28-2)5-17(15)22/h3-9H,10H2,1-2H3,(H2,23,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	427	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM430082 (5-((6-chloropyridin-3-yl)methoxy)-4-(4-fluoropheny...) Show SMILES NC(=O)c1cc(c(OCc2ccc(Cl)nc2)cn1)-c1ccc(F)cc1 Show InChI InChI=1S/C18H13ClFN3O2/c19-17-6-1-11(8-23-17)10-25-16-9-22-15(18(21)24)7-14(16)12-2-4-13(20)5-3-12/h1-9H,10H2,(H2,21,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	429	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University US Patent					Assay Description Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...				US Patent US10538491 (2020) BindingDB Entry DOI: 10.7270/Q2GT5QKF
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM430215 (5-((3-Cyanobenzyl)oxy)-4-(4-fluorophenyl)picolinam...) Show SMILES NC(=O)c1cc(c(OCc2cccc(c2)C#N)cn1)-c1ccc(F)cc1 Show InChI InChI=1S/C20H14FN3O2/c21-16-6-4-15(5-7-16)17-9-18(20(23)25)24-11-19(17)26-12-14-3-1-2-13(8-14)10-22/h1-9,11H,12H2,(H2,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	429	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University US Patent					Assay Description Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...				US Patent US10538491 (2020) BindingDB Entry DOI: 10.7270/Q2GT5QKF
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM430156 (4-(2-fluoro-4-methoxyphenyl)-5-((6-(trifluoromethy...) Show SMILES COc1ccc(c(F)c1)-c1cc(ncc1OCc1ccc(nc1)C(F)(F)F)C(N)=O Show InChI InChI=1S/C20H15F4N3O3/c1-29-12-3-4-13(15(21)6-12)14-7-16(19(25)28)26-9-17(14)30-10-11-2-5-18(27-8-11)20(22,23)24/h2-9H,10H2,1H3,(H2,25,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	440	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University US Patent					Assay Description Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...				US Patent US10538491 (2020) BindingDB Entry DOI: 10.7270/Q2GT5QKF
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50503459 (CHEMBL4475753) Show SMILES COc1ccc(cc1)-c1cc(nc2cc(COc3cnc(C)nc3)sc12)C(N)=O Show InChI InChI=1S/C21H18N4O3S/c1-12-23-9-15(10-24-12)28-11-16-7-18-20(29-16)17(8-19(25-18)21(22)26)13-3-5-14(27-2)6-4-13/h3-10H,11H2,1-2H3,(H2,22,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	447	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50503459 (CHEMBL4475753) Show SMILES COc1ccc(cc1)-c1cc(nc2cc(COc3cnc(C)nc3)sc12)C(N)=O Show InChI InChI=1S/C21H18N4O3S/c1-12-23-9-15(10-24-12)28-11-16-7-18-20(29-16)17(8-19(25-18)21(22)26)13-3-5-14(27-2)6-4-13/h3-10H,11H2,1-2H3,(H2,22,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	447	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM430163 (4-(4-fluorophenyl)-5-(((2-(trifluoromethyl)pyridin...) Show SMILES NC(=O)c1cc(c(COc2ccnc(c2)C(F)(F)F)cn1)-c1ccc(F)cc1 Show InChI InChI=1S/C19H13F4N3O2/c20-13-3-1-11(2-4-13)15-8-16(18(24)27)26-9-12(15)10-28-14-5-6-25-17(7-14)19(21,22)23/h1-9H,10H2,(H2,24,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	477	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University US Patent					Assay Description Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...				US Patent US10538491 (2020) BindingDB Entry DOI: 10.7270/Q2GT5QKF
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM430190 (4-(4-fluorophenyl)-5-((1-((2-(trifluoromethyl)pyri...) Show SMILES CC(COc1ccnc(c1)C(F)(F)F)Oc1cnc(cc1-c1ccc(F)cc1)C(N)=O Show InChI InChI=1S/C21H17F4N3O3/c1-12(11-30-15-6-7-27-19(8-15)21(23,24)25)31-18-10-28-17(20(26)29)9-16(18)13-2-4-14(22)5-3-13/h2-10,12H,11H2,1H3,(H2,26,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	483	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University US Patent					Assay Description Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...				US Patent US10538491 (2020) BindingDB Entry DOI: 10.7270/Q2GT5QKF
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM430183 (4-(4-fluorophenyl)-5-(2-((6-fluoropyridin-3-yl)oxy...) Show SMILES NC(=O)c1cc(c(OCCOc2ccc(F)nc2)cn1)-c1ccc(F)cc1 Show InChI InChI=1S/C19H15F2N3O3/c20-13-3-1-12(2-4-13)15-9-16(19(22)25)23-11-17(15)27-8-7-26-14-5-6-18(21)24-10-14/h1-6,9-11H,7-8H2,(H2,22,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	502	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University US Patent					Assay Description Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...				US Patent US10538491 (2020) BindingDB Entry DOI: 10.7270/Q2GT5QKF
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM430122 (4-(4-fluorophenyl)-5-(1-(pyridin-4-yl)ethoxy)picol...) Show SMILES CC(Oc1cnc(cc1-c1ccc(F)cc1)C(N)=O)c1ccncc1 Show InChI InChI=1S/C19H16FN3O2/c1-12(13-6-8-22-9-7-13)25-18-11-23-17(19(21)24)10-16(18)14-2-4-15(20)5-3-14/h2-12H,1H3,(H2,21,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	504	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University US Patent					Assay Description Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...				US Patent US10538491 (2020) BindingDB Entry DOI: 10.7270/Q2GT5QKF
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM430112 (4-(4-fluorophenyl)-5-(pyridin-3-ylmethoxy)picolina...) Show SMILES NC(=O)c1cc(c(OCc2cccnc2)cn1)-c1ccc(F)cc1 Show InChI InChI=1S/C18H14FN3O2/c19-14-5-3-13(4-6-14)15-8-16(18(20)23)22-10-17(15)24-11-12-2-1-7-21-9-12/h1-10H,11H2,(H2,20,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	507	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University US Patent					Assay Description Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...				US Patent US10538491 (2020) BindingDB Entry DOI: 10.7270/Q2GT5QKF
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM430225 (5-(2-(3-cyano-2-fluorophenoxy)ethoxy)-4-(4-fluorop...) Show SMILES NC(=O)c1cc(c(OCCOc2cccc(C#N)c2F)cn1)-c1ccc(F)cc1 Show InChI InChI=1S/C21H15F2N3O3/c22-15-6-4-13(5-7-15)16-10-17(21(25)27)26-12-19(16)29-9-8-28-18-3-1-2-14(11-24)20(18)23/h1-7,10,12H,8-9H2,(H2,25,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	528	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University US Patent					Assay Description Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...				US Patent US10538491 (2020) BindingDB Entry DOI: 10.7270/Q2GT5QKF
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM430148 (5-((2,2-dimethylmorpholino)methyl)-4-(4-fluorophen...) Show SMILES CC1(C)CN(Cc2cnc(cc2-c2ccc(F)cc2)C(N)=O)CCO1 Show InChI InChI=1S/C19H22FN3O2/c1-19(2)12-23(7-8-25-19)11-14-10-22-17(18(21)24)9-16(14)13-3-5-15(20)6-4-13/h3-6,9-10H,7-8,11-12H2,1-2H3,(H2,21,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	531	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University US Patent					Assay Description Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...				US Patent US10538491 (2020) BindingDB Entry DOI: 10.7270/Q2GT5QKF
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50503462 (CHEMBL4527834) Show SMILES C[C@H]1CN(Cc2cc3nc(cc(-c4ccc(F)cc4)c3s2)C(N)=O)C[C@@H](C)O1 |r| Show InChI InChI=1S/C21H22FN3O2S/c1-12-9-25(10-13(2)27-12)11-16-7-18-20(28-16)17(8-19(24-18)21(23)26)14-3-5-15(22)6-4-14/h3-8,12-13H,9-11H2,1-2H3,(H2,23,26)/t12-,13+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX
					More data for this Ligand-Target Pair

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