Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Geranylgeranyl transferase type-1 subunit beta (Rattus norvegicus) | BDBM14459 ((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Temple University Curated by ChEMBL | Assay Description Inhibition of rat brain GGTase1 assessed as decrease in transfer of [3H]H]geranylgeranyl from [3H]geranylgeranyl PPi to H-Ras-CVLL after 30 mins by l... | J Med Chem 61: 3239-3252 (2018) Article DOI: 10.1021/acs.jmedchem.6b01817 BindingDB Entry DOI: 10.7270/Q2542R5N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Geranylgeranyl transferase type-1 subunit beta (Rattus norvegicus) | BDBM50481906 (CHEMBL1075839) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Max Planck Institute of Molecular Physiology Curated by ChEMBL | Assay Description Inhibition of rat recombinant GGTase-1 by SDS-PAGE end point assay | J Med Chem 52: 8025-37 (2009) Article DOI: 10.1021/jm901117d BindingDB Entry DOI: 10.7270/Q25X2CS3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Rattus norvegicus (rat)) | BDBM50075437 (2,4,5-Trifluoro-6-nitro-3-((2E,6E)-3,7,11-trimethy...) | PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.25E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research Curated by ChEMBL | Assay Description In vitro inhibition of rat brain cytosol Geranylgeranyl transferase type I | Bioorg Med Chem Lett 9: 623-6 (1999) BindingDB Entry DOI: 10.7270/Q28P5ZN0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Geranylgeranyl transferase type-1 subunit beta (Rattus norvegicus) | BDBM50481911 (CHEMBL1075809) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Max Planck Institute of Molecular Physiology Curated by ChEMBL | Assay Description Inhibition of rat recombinant GGTase-1 by SDS-PAGE end point assay | J Med Chem 52: 8025-37 (2009) Article DOI: 10.1021/jm901117d BindingDB Entry DOI: 10.7270/Q25X2CS3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Geranylgeranyl transferase type-1 subunit beta (Rattus norvegicus) | BDBM50481907 (CHEMBL1075810) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Max Planck Institute of Molecular Physiology Curated by ChEMBL | Assay Description Inhibition of rat recombinant GGTase-1 by SDS-PAGE end point assay | J Med Chem 52: 8025-37 (2009) Article DOI: 10.1021/jm901117d BindingDB Entry DOI: 10.7270/Q25X2CS3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Geranylgeranyl transferase type-1 subunit beta (Rattus norvegicus) | BDBM50481909 (CHEMBL1075863) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | KEGG PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 3.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Max Planck Institute of Molecular Physiology Curated by ChEMBL | Assay Description Inhibition of rat recombinant GGTase-1 by SDS-PAGE end point assay | J Med Chem 52: 8025-37 (2009) Article DOI: 10.1021/jm901117d BindingDB Entry DOI: 10.7270/Q25X2CS3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Rattus norvegicus (rat)) | BDBM50075439 (3-Benzyloxy-2,4,5-trifluoro-6-nitro-phenol | CHEMB...) | PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 5.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research Curated by ChEMBL | Assay Description In vitro inhibition of rat brain cytosol Geranylgeranyl transferase type I | Bioorg Med Chem Lett 9: 623-6 (1999) BindingDB Entry DOI: 10.7270/Q28P5ZN0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Rattus norvegicus (rat)) | BDBM50075440 (2,4,5-Trifluoro-3-(4-isopropenyl-cyclohex-1-enylme...) | PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 8.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research Curated by ChEMBL | Assay Description In vitro inhibition of rat brain cytosol Geranylgeranyl transferase type I | Bioorg Med Chem Lett 9: 623-6 (1999) BindingDB Entry DOI: 10.7270/Q28P5ZN0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Geranylgeranyl transferase type-1 subunit beta (Rattus norvegicus) | BDBM50481908 (CHEMBL1075861) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | 9.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Max Planck Institute of Molecular Physiology Curated by ChEMBL | Assay Description Inhibition of rat recombinant GGTase-1 by SDS-PAGE end point assay | J Med Chem 52: 8025-37 (2009) Article DOI: 10.1021/jm901117d BindingDB Entry DOI: 10.7270/Q25X2CS3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Geranylgeranyl transferase type-1 subunit beta (Rattus norvegicus) | BDBM50481910 (CHEMBL1075859) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | KEGG PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Max Planck Institute of Molecular Physiology Curated by ChEMBL | Assay Description Inhibition of rat recombinant GGTase-1 by SDS-PAGE end point assay | J Med Chem 52: 8025-37 (2009) Article DOI: 10.1021/jm901117d BindingDB Entry DOI: 10.7270/Q25X2CS3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Geranylgeranyl transferase type-1 subunit beta (Rattus norvegicus) | BDBM50481912 (CHEMBL1075865) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Max Planck Institute of Molecular Physiology Curated by ChEMBL | Assay Description Inhibition of rat recombinant GGTase-1 by SDS-PAGE end point assay | J Med Chem 52: 8025-37 (2009) Article DOI: 10.1021/jm901117d BindingDB Entry DOI: 10.7270/Q25X2CS3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Rattus norvegicus (rat)) | BDBM50075443 (3-Dodecyloxy-2,4,5-trifluoro-6-nitro-phenol | CHEM...) | PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research Curated by ChEMBL | Assay Description In vitro inhibition of rat brain cytosol Geranylgeranyl transferase type I | Bioorg Med Chem Lett 9: 623-6 (1999) BindingDB Entry DOI: 10.7270/Q28P5ZN0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Geranylgeranyl transferase type-1 subunit beta (Rattus norvegicus) | BDBM50504717 (CHEMBL4459281) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.22E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Iowa Curated by ChEMBL | Assay Description Inhibition of recombinant rat GGtase-1 expressed in Escherichia coli using dansyl-GCVLL as substrate after 1.5 hrs by spectrofluorimetric analysis | Bioorg Med Chem Lett 29: (2019) Article DOI: 10.1016/j.bmcl.2019.126757 BindingDB Entry DOI: 10.7270/Q2JM2DW5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Geranylgeranyl transferase type-1 subunit beta (Rattus norvegicus) | BDBM50504718 (CHEMBL4564870) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.45E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Iowa Curated by ChEMBL | Assay Description Inhibition of recombinant rat GGtase-1 expressed in Escherichia coli using dansyl-GCVLL as substrate after 1.5 hrs by spectrofluorimetric analysis | Bioorg Med Chem Lett 29: (2019) Article DOI: 10.1016/j.bmcl.2019.126757 BindingDB Entry DOI: 10.7270/Q2JM2DW5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Rattus norvegicus (rat)) | BDBM50075442 (3-Allyloxy-2,4,5-trifluoro-6-nitro-phenol | CHEMBL...) | PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research Curated by ChEMBL | Assay Description In vitro inhibition of rat brain cytosol Geranylgeranyl transferase type I | Bioorg Med Chem Lett 9: 623-6 (1999) BindingDB Entry DOI: 10.7270/Q28P5ZN0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Rattus norvegicus (rat)) | BDBM50075438 (3-(Biphenyl-4-ylmethoxy)-2,4,5-trifluoro-6-nitro-p...) | PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research Curated by ChEMBL | Assay Description In vitro inhibition of rat brain cytosol Geranylgeranyl transferase type I | Bioorg Med Chem Lett 9: 623-6 (1999) BindingDB Entry DOI: 10.7270/Q28P5ZN0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Rattus norvegicus (rat)) | BDBM50075441 (2,4,5-Trifluoro-3-(naphthalen-2-ylmethoxy)-6-nitro...) | PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research Curated by ChEMBL | Assay Description In vitro inhibition of rat brain cytosol Geranylgeranyl transferase type I | Bioorg Med Chem Lett 9: 623-6 (1999) BindingDB Entry DOI: 10.7270/Q28P5ZN0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Geranylgeranyl transferase type-1 subunit beta (Rattus norvegicus) | BDBM50504716 (CHEMBL4589567) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Iowa Curated by ChEMBL | Assay Description Inhibition of recombinant rat GGtase-1 expressed in Escherichia coli using dansyl-GCVLL as substrate after 1.5 hrs by spectrofluorimetric analysis | Bioorg Med Chem Lett 29: (2019) Article DOI: 10.1016/j.bmcl.2019.126757 BindingDB Entry DOI: 10.7270/Q2JM2DW5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Geranylgeranyl transferase type-1 subunit beta (Rattus norvegicus) | BDBM50273716 (CHEMBL457423 | [2-(Benzoimidazol-1-yl)ethyl]-bisph...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Iowa Curated by ChEMBL | Assay Description Inhibition of recombinant rat GGtase-1 expressed in Escherichia coli using dansyl-GCVLL as substrate after 1.5 hrs by spectrofluorimetric analysis | Bioorg Med Chem Lett 29: (2019) Article DOI: 10.1016/j.bmcl.2019.126757 BindingDB Entry DOI: 10.7270/Q2JM2DW5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Geranylgeranyl transferase type-1 subunit beta (Rattus norvegicus) | BDBM50504719 (CHEMBL4438314) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Iowa Curated by ChEMBL | Assay Description Inhibition of recombinant rat GGtase-1 expressed in Escherichia coli using dansyl-GCVLL as substrate after 1.5 hrs by spectrofluorimetric analysis | Bioorg Med Chem Lett 29: (2019) Article DOI: 10.1016/j.bmcl.2019.126757 BindingDB Entry DOI: 10.7270/Q2JM2DW5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Geranylgeranyl transferase type-1 subunit beta (Rattus norvegicus) | BDBM50504720 (CHEMBL4529809) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Iowa Curated by ChEMBL | Assay Description Inhibition of recombinant rat GGtase-1 expressed in Escherichia coli using dansyl-GCVLL as substrate after 1.5 hrs by spectrofluorimetric analysis | Bioorg Med Chem Lett 29: (2019) Article DOI: 10.1016/j.bmcl.2019.126757 BindingDB Entry DOI: 10.7270/Q2JM2DW5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Geranylgeranyl transferase type-1 subunit beta (Rattus norvegicus) | BDBM50504715 (CHEMBL4514446) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Iowa Curated by ChEMBL | Assay Description Inhibition of recombinant rat GGtase-1 expressed in Escherichia coli using dansyl-GCVLL as substrate after 1.5 hrs by spectrofluorimetric analysis | Bioorg Med Chem Lett 29: (2019) Article DOI: 10.1016/j.bmcl.2019.126757 BindingDB Entry DOI: 10.7270/Q2JM2DW5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Geranylgeranyl transferase type-1 subunit beta (Rattus norvegicus) | BDBM50504714 (CHEMBL4460301) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Iowa Curated by ChEMBL | Assay Description Inhibition of recombinant rat GGtase-1 expressed in Escherichia coli using dansyl-GCVLL as substrate after 1.5 hrs by spectrofluorimetric analysis | Bioorg Med Chem Lett 29: (2019) Article DOI: 10.1016/j.bmcl.2019.126757 BindingDB Entry DOI: 10.7270/Q2JM2DW5 | |||||||||||
More data for this Ligand-Target Pair |