Found 69 hits of ic50 for UniProtKB: P40145 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Adenylate cyclase type 8
(Homo sapiens (Human)) | BDBM50604212
(CHEMBL5190252)Show SMILES CCc1cc(=O)[nH]c(n1)-n1nc(C)cc1NC(=O)c1cccc(c1)C(C)(C)C | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 380 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01759
BindingDB Entry DOI: 10.7270/Q29G5RWW |
More data for this
Ligand-Target Pair | |
Adenylate cyclase type 8
(Homo sapiens (Human)) | BDBM50604214
(CHEMBL5170189)Show SMILES CCc1cc(=O)[nH]c(n1)-n1nc(C)cc1NC(=O)c1cccc(c1)-c1ccccc1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 570 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01759
BindingDB Entry DOI: 10.7270/Q29G5RWW |
More data for this
Ligand-Target Pair | |
Adenylate cyclase type 8
(Homo sapiens (Human)) | BDBM50604215
(CHEMBL5195432)Show SMILES CCc1cc(=O)[nH]c(n1)-n1nc(C)cc1NC(=O)c1ccc(cc1)-c1ccccc1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01759
BindingDB Entry DOI: 10.7270/Q29G5RWW |
More data for this
Ligand-Target Pair | |
Adenylate cyclase type 8
(Homo sapiens (Human)) | BDBM50604227
(CHEMBL5182403)Show SMILES CCc1cc(=O)[nH]c(n1)-n1nc(C)cc1NC(=O)c1ccc(C)c(C)c1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 710 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01759
BindingDB Entry DOI: 10.7270/Q29G5RWW |
More data for this
Ligand-Target Pair | |
Adenylate cyclase type 8
(Homo sapiens (Human)) | BDBM50604199
(CHEMBL5178772)Show SMILES CCc1cc(=O)[nH]c(n1)-n1nc(C)cc1NC(=O)c1ccc(F)cc1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 780 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01759
BindingDB Entry DOI: 10.7270/Q29G5RWW |
More data for this
Ligand-Target Pair | |
Adenylate cyclase type 8
(Homo sapiens (Human)) | BDBM50604222
(CHEMBL5187427)Show SMILES CCc1cc(=O)[nH]c(n1)-n1nc(C)cc1NC(=O)c1ccc(cc1)N(C)C | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01759
BindingDB Entry DOI: 10.7270/Q29G5RWW |
More data for this
Ligand-Target Pair | |
Adenylate cyclase type 8
(Homo sapiens (Human)) | BDBM50604200
(CHEMBL5205425)Show SMILES CCc1cc(=O)[nH]c(n1)-n1nc(C)cc1NC(=O)c1cccc(Cl)c1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01759
BindingDB Entry DOI: 10.7270/Q29G5RWW |
More data for this
Ligand-Target Pair | |
Adenylate cyclase type 8
(Homo sapiens (Human)) | BDBM50604213
(CHEMBL2098167 | GSK1783663A | TCMDC-142373)Show SMILES CCc1cc(=O)[nH]c(n1)-n1nc(C)cc1NC(=O)c1ccc(cc1)C(C)(C)C | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01759
BindingDB Entry DOI: 10.7270/Q29G5RWW |
More data for this
Ligand-Target Pair | |
Adenylate cyclase type 8
(Homo sapiens (Human)) | BDBM50604218
(CHEMBL5197311)Show SMILES CCc1cc(=O)[nH]c(n1)-n1nc(C)cc1NC(=O)c1cccc(SC)c1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01759
BindingDB Entry DOI: 10.7270/Q29G5RWW |
More data for this
Ligand-Target Pair | |
Adenylate cyclase type 8
(Homo sapiens (Human)) | BDBM50604206
(CHEMBL5197376)Show SMILES CCc1cc(=O)[nH]c(n1)-n1nc(C)cc1NC(=O)c1cccc(c1)C(F)(F)F | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01759
BindingDB Entry DOI: 10.7270/Q29G5RWW |
More data for this
Ligand-Target Pair | |
Adenylate cyclase type 8
(Homo sapiens (Human)) | BDBM50521058
(CHEMBL4456548)Show InChI InChI=1S/C21H21N3O2/c25-19(18-13-7-12-17(14-18)15-8-3-1-4-9-15)22-21-24-23-20(26-21)16-10-5-2-6-11-16/h1,3-4,7-9,12-14,16H,2,5-6,10-11H2,(H,22,24,25) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University
Curated by ChEMBL
| Assay Description
Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A2... |
Eur J Med Chem 162: 568-585 (2019)
Article DOI: 10.1016/j.ejmech.2018.11.036
BindingDB Entry DOI: 10.7270/Q23X8B2X |
More data for this
Ligand-Target Pair | |
Adenylate cyclase type 8
(Homo sapiens (Human)) | BDBM50604198
(CHEMBL5186455)Show SMILES CCc1cc(=O)[nH]c(n1)-n1nc(C)cc1NC(=O)c1cccc(F)c1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01759
BindingDB Entry DOI: 10.7270/Q29G5RWW |
More data for this
Ligand-Target Pair | |
Adenylate cyclase type 8
(Homo sapiens (Human)) | BDBM50604228
(CHEMBL5178349)Show SMILES CCc1cc(=O)[nH]c(n1)-n1nc(C)cc1NC(=O)c1cc(C)cc(C)c1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01759
BindingDB Entry DOI: 10.7270/Q29G5RWW |
More data for this
Ligand-Target Pair | |
Adenylate cyclase type 8
(Homo sapiens (Human)) | BDBM50604193
(CHEMBL5187824)Show SMILES CCc1cc(=O)[nH]c(n1)-n1nc(C)cc1NC(=O)c1ccccc1F | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01759
BindingDB Entry DOI: 10.7270/Q29G5RWW |
More data for this
Ligand-Target Pair | |
Adenylate cyclase type 8
(Homo sapiens (Human)) | BDBM50604211
(CHEMBL5186344)Show SMILES CCc1cc(=O)[nH]c(n1)-n1nc(C)cc1NC(=O)c1cccc(c1)C1CC1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01759
BindingDB Entry DOI: 10.7270/Q29G5RWW |
More data for this
Ligand-Target Pair | |
Adenylate cyclase type 8
(Homo sapiens (Human)) | BDBM50521074
(CHEMBL4467742)Show InChI InChI=1S/C21H21N3O2/c1-2-14-7-9-16(10-8-14)19(25)22-21-24-23-20(26-21)18-12-11-15-5-3-4-6-17(15)13-18/h7-13H,2-6H2,1H3,(H,22,24,25) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University
Curated by ChEMBL
| Assay Description
Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A2... |
Eur J Med Chem 162: 568-585 (2019)
Article DOI: 10.1016/j.ejmech.2018.11.036
BindingDB Entry DOI: 10.7270/Q23X8B2X |
More data for this
Ligand-Target Pair | |
Adenylate cyclase type 8
(Homo sapiens (Human)) | BDBM50604202
(CHEMBL5199983)Show SMILES CCc1cc(=O)[nH]c(n1)-n1nc(C)cc1NC(=O)c1cccc(Br)c1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01759
BindingDB Entry DOI: 10.7270/Q29G5RWW |
More data for this
Ligand-Target Pair | |
Adenylate cyclase type 8
(Homo sapiens (Human)) | BDBM50521109
(CHEMBL4585588)Show SMILES Cc1cc(cc(c1)C(F)(F)F)C(=O)Nc1nnc(o1)-c1ccc2CCCCc2c1 Show InChI InChI=1S/C21H18F3N3O2/c1-12-8-16(11-17(9-12)21(22,23)24)18(28)25-20-27-26-19(29-20)15-7-6-13-4-2-3-5-14(13)10-15/h6-11H,2-5H2,1H3,(H,25,27,28) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University
Curated by ChEMBL
| Assay Description
Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A2... |
Eur J Med Chem 162: 568-585 (2019)
Article DOI: 10.1016/j.ejmech.2018.11.036
BindingDB Entry DOI: 10.7270/Q23X8B2X |
More data for this
Ligand-Target Pair | |
Adenylate cyclase type 8
(Homo sapiens (Human)) | BDBM50604201
(CHEMBL5203054)Show SMILES CCc1cc(=O)[nH]c(n1)-n1nc(C)cc1NC(=O)c1ccc(Cl)cc1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01759
BindingDB Entry DOI: 10.7270/Q29G5RWW |
More data for this
Ligand-Target Pair | |
Adenylate cyclase type 8
(Homo sapiens (Human)) | BDBM50604210
(CHEMBL5174303)Show SMILES CCc1cc(=O)[nH]c(n1)-n1nc(C)cc1NC(=O)c1cccc(c1)C(C)C | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01759
BindingDB Entry DOI: 10.7270/Q29G5RWW |
More data for this
Ligand-Target Pair | |
Adenylate cyclase type 8
(Homo sapiens (Human)) | BDBM50604204
(CHEMBL5188949)Show SMILES CCc1cc(=O)[nH]c(n1)-n1nc(C)cc1NC(=O)c1cccc(C)c1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01759
BindingDB Entry DOI: 10.7270/Q29G5RWW |
More data for this
Ligand-Target Pair | |
Adenylate cyclase type 8
(Homo sapiens (Human)) | BDBM50604197
(CHEMBL5180340)Show SMILES CCc1cc(=O)[nH]c(n1)-n1nc(C)cc1NC(=O)c1ccccn1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01759
BindingDB Entry DOI: 10.7270/Q29G5RWW |
More data for this
Ligand-Target Pair | |
Adenylate cyclase type 8
(Homo sapiens (Human)) | BDBM50604223
(CHEMBL5193541)Show SMILES CCc1cc(=O)[nH]c(n1)-n1nc(C)cc1NC(=O)Cc1ccccc1F | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01759
BindingDB Entry DOI: 10.7270/Q29G5RWW |
More data for this
Ligand-Target Pair | |
Adenylate cyclase type 8
(Homo sapiens (Human)) | BDBM50604226
(CHEMBL5172009)Show SMILES CCc1cc(=O)[nH]c(n1)-n1nc(C)cc1NC(=O)c1cc(C)ccc1F | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01759
BindingDB Entry DOI: 10.7270/Q29G5RWW |
More data for this
Ligand-Target Pair | |
Adenylate cyclase type 8
(Homo sapiens (Human)) | BDBM50604208
(CHEMBL5202029)Show SMILES CCc1cccc(c1)C(=O)Nc1cc(C)nn1-c1nc(CC)cc(=O)[nH]1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01759
BindingDB Entry DOI: 10.7270/Q29G5RWW |
More data for this
Ligand-Target Pair | |
Adenylate cyclase type 8
(Homo sapiens (Human)) | BDBM50521096
(CHEMBL4537053)Show InChI InChI=1S/C19H16ClN3O2/c20-16-9-7-13(8-10-16)17(24)21-19-23-22-18(25-19)15-6-5-12-3-1-2-4-14(12)11-15/h5-11H,1-4H2,(H,21,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University
Curated by ChEMBL
| Assay Description
Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A2... |
Eur J Med Chem 162: 568-585 (2019)
Article DOI: 10.1016/j.ejmech.2018.11.036
BindingDB Entry DOI: 10.7270/Q23X8B2X |
More data for this
Ligand-Target Pair | |
Adenylate cyclase type 8
(Homo sapiens (Human)) | BDBM50521093
(CHEMBL4457916)Show SMILES Cc1cc(cc(c1)C(F)(F)F)C(=O)Nc1nnc(o1)-c1ccc(F)cc1 Show InChI InChI=1S/C17H11F4N3O2/c1-9-6-11(8-12(7-9)17(19,20)21)14(25)22-16-24-23-15(26-16)10-2-4-13(18)5-3-10/h2-8H,1H3,(H,22,24,25) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University
Curated by ChEMBL
| Assay Description
Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A2... |
Eur J Med Chem 162: 568-585 (2019)
Article DOI: 10.1016/j.ejmech.2018.11.036
BindingDB Entry DOI: 10.7270/Q23X8B2X |
More data for this
Ligand-Target Pair | |
Adenylate cyclase type 8
(Homo sapiens (Human)) | BDBM50521061
(CHEMBL4464131)Show InChI InChI=1S/C19H16FN3O2/c20-16-7-3-6-14(11-16)17(24)21-19-23-22-18(25-19)15-9-8-12-4-1-2-5-13(12)10-15/h3,6-11H,1-2,4-5H2,(H,21,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University
Curated by ChEMBL
| Assay Description
Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A2... |
Eur J Med Chem 162: 568-585 (2019)
Article DOI: 10.1016/j.ejmech.2018.11.036
BindingDB Entry DOI: 10.7270/Q23X8B2X |
More data for this
Ligand-Target Pair | |
Adenylate cyclase type 8
(Homo sapiens (Human)) | BDBM50604219
(CHEMBL5176376)Show SMILES CCOc1cccc(c1)C(=O)Nc1cc(C)nn1-c1nc(CC)cc(=O)[nH]1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01759
BindingDB Entry DOI: 10.7270/Q29G5RWW |
More data for this
Ligand-Target Pair | |
Adenylate cyclase type 8
(Homo sapiens (Human)) | BDBM50521071
(CHEMBL2093209 | TDR77394)Show InChI InChI=1S/C20H19N3O3/c1-25-17-8-4-7-15(12-17)18(24)21-20-23-22-19(26-20)16-10-9-13-5-2-3-6-14(13)11-16/h4,7-12H,2-3,5-6H2,1H3,(H,21,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University
Curated by ChEMBL
| Assay Description
Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A2... |
Eur J Med Chem 162: 568-585 (2019)
Article DOI: 10.1016/j.ejmech.2018.11.036
BindingDB Entry DOI: 10.7270/Q23X8B2X |
More data for this
Ligand-Target Pair | |
Adenylate cyclase type 8
(Homo sapiens (Human)) | BDBM50521067
(CHEMBL4452051)Show SMILES COc1ccc(cc1)-c1nnc(NC(=O)c2cc(nc3ccccc23)-c2cccs2)o1 Show InChI InChI=1S/C23H16N4O3S/c1-29-15-10-8-14(9-11-15)22-26-27-23(30-22)25-21(28)17-13-19(20-7-4-12-31-20)24-18-6-3-2-5-16(17)18/h2-13H,1H3,(H,25,27,28) | PDB
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| n/a | n/a | 5.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University
Curated by ChEMBL
| Assay Description
Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A2... |
Eur J Med Chem 162: 568-585 (2019)
Article DOI: 10.1016/j.ejmech.2018.11.036
BindingDB Entry DOI: 10.7270/Q23X8B2X |
More data for this
Ligand-Target Pair | |
Adenylate cyclase type 8
(Homo sapiens (Human)) | BDBM50604209
(CHEMBL5169392)Show SMILES CCc1ccc(cc1)C(=O)Nc1cc(C)nn1-c1nc(CC)cc(=O)[nH]1 | PDB
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| n/a | n/a | 6.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01759
BindingDB Entry DOI: 10.7270/Q29G5RWW |
More data for this
Ligand-Target Pair | |
Adenylate cyclase type 8
(Homo sapiens (Human)) | BDBM50521100
(CHEMBL4575792)Show SMILES Fc1ccc(cc1)-c1nnc(NC(=O)c2cccc(c2)-c2ccccc2)o1 Show InChI InChI=1S/C21H14FN3O2/c22-18-11-9-15(10-12-18)20-24-25-21(27-20)23-19(26)17-8-4-7-16(13-17)14-5-2-1-3-6-14/h1-13H,(H,23,25,26) | PDB
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| n/a | n/a | 7.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University
Curated by ChEMBL
| Assay Description
Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A2... |
Eur J Med Chem 162: 568-585 (2019)
Article DOI: 10.1016/j.ejmech.2018.11.036
BindingDB Entry DOI: 10.7270/Q23X8B2X |
More data for this
Ligand-Target Pair | |
Adenylate cyclase type 8
(Homo sapiens (Human)) | BDBM50521056
(CHEMBL4543838)Show InChI InChI=1S/C17H18F3N3O2/c1-10-7-8-12(9-13(10)17(18,19)20)14(24)21-16-23-22-15(25-16)11-5-3-2-4-6-11/h7-9,11H,2-6H2,1H3,(H,21,23,24) | PDB
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UniChem
| Article
PubMed
| n/a | n/a | 7.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University
Curated by ChEMBL
| Assay Description
Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A2... |
Eur J Med Chem 162: 568-585 (2019)
Article DOI: 10.1016/j.ejmech.2018.11.036
BindingDB Entry DOI: 10.7270/Q23X8B2X |
More data for this
Ligand-Target Pair | |
Adenylate cyclase type 8
(Homo sapiens (Human)) | BDBM50521087
(CHEMBL4549401)Show SMILES Fc1ccc(cc1)-c1nnc(NC(=O)c2ccc(cc2)-c2ccccc2)o1 Show InChI InChI=1S/C21H14FN3O2/c22-18-12-10-17(11-13-18)20-24-25-21(27-20)23-19(26)16-8-6-15(7-9-16)14-4-2-1-3-5-14/h1-13H,(H,23,25,26) | PDB
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PubMed
| n/a | n/a | 7.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University
Curated by ChEMBL
| Assay Description
Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A2... |
Eur J Med Chem 162: 568-585 (2019)
Article DOI: 10.1016/j.ejmech.2018.11.036
BindingDB Entry DOI: 10.7270/Q23X8B2X |
More data for this
Ligand-Target Pair | |
Adenylate cyclase type 8
(Homo sapiens (Human)) | BDBM50521057
(CHEMBL4467466)Show SMILES FC(F)(F)c1cccc(c1)C(=O)Nc1nnc(o1)-c1ccc2CCCCc2c1 Show InChI InChI=1S/C20H16F3N3O2/c21-20(22,23)16-7-3-6-14(11-16)17(27)24-19-26-25-18(28-19)15-9-8-12-4-1-2-5-13(12)10-15/h3,6-11H,1-2,4-5H2,(H,24,26,27) | PDB
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| n/a | n/a | 7.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University
Curated by ChEMBL
| Assay Description
Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A2... |
Eur J Med Chem 162: 568-585 (2019)
Article DOI: 10.1016/j.ejmech.2018.11.036
BindingDB Entry DOI: 10.7270/Q23X8B2X |
More data for this
Ligand-Target Pair | |
Adenylate cyclase type 8
(Homo sapiens (Human)) | BDBM50521072
(CHEMBL4437081)Show InChI InChI=1S/C20H19N3O2/c1-13-6-8-15(9-7-13)18(24)21-20-23-22-19(25-20)17-11-10-14-4-2-3-5-16(14)12-17/h6-12H,2-5H2,1H3,(H,21,23,24) | PDB
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| PC cid
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UniChem
| Article
PubMed
| n/a | n/a | 7.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University
Curated by ChEMBL
| Assay Description
Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A2... |
Eur J Med Chem 162: 568-585 (2019)
Article DOI: 10.1016/j.ejmech.2018.11.036
BindingDB Entry DOI: 10.7270/Q23X8B2X |
More data for this
Ligand-Target Pair | |
Adenylate cyclase type 8
(Homo sapiens (Human)) | BDBM50521059
(CHEMBL4449979)Show SMILES COc1cc(cc(c1)C(F)(F)F)C(=O)Nc1nnc(o1)C1CCCCC1 Show InChI InChI=1S/C17H18F3N3O3/c1-25-13-8-11(7-12(9-13)17(18,19)20)14(24)21-16-23-22-15(26-16)10-5-3-2-4-6-10/h7-10H,2-6H2,1H3,(H,21,23,24) | PDB
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| PC cid
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| Article
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| n/a | n/a | 9.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University
Curated by ChEMBL
| Assay Description
Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A2... |
Eur J Med Chem 162: 568-585 (2019)
Article DOI: 10.1016/j.ejmech.2018.11.036
BindingDB Entry DOI: 10.7270/Q23X8B2X |
More data for this
Ligand-Target Pair | |
Adenylate cyclase type 8
(Homo sapiens (Human)) | BDBM50521103
(CHEMBL4466580)Show SMILES Cc1ccc(cc1C(F)(F)F)C(=O)Nc1nnc(o1)-c1ccc(F)cc1 Show InChI InChI=1S/C17H11F4N3O2/c1-9-2-3-11(8-13(9)17(19,20)21)14(25)22-16-24-23-15(26-16)10-4-6-12(18)7-5-10/h2-8H,1H3,(H,22,24,25) | PDB
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| n/a | n/a | 9.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University
Curated by ChEMBL
| Assay Description
Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A2... |
Eur J Med Chem 162: 568-585 (2019)
Article DOI: 10.1016/j.ejmech.2018.11.036
BindingDB Entry DOI: 10.7270/Q23X8B2X |
More data for this
Ligand-Target Pair | |
Adenylate cyclase type 8
(Homo sapiens (Human)) | BDBM50521111
(CHEMBL4464808)Show InChI InChI=1S/C20H19N3O2S/c1-26-17-8-4-7-15(12-17)18(24)21-20-23-22-19(25-20)16-10-9-13-5-2-3-6-14(13)11-16/h4,7-12H,2-3,5-6H2,1H3,(H,21,23,24) | PDB
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PubMed
| n/a | n/a | 9.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University
Curated by ChEMBL
| Assay Description
Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A2... |
Eur J Med Chem 162: 568-585 (2019)
Article DOI: 10.1016/j.ejmech.2018.11.036
BindingDB Entry DOI: 10.7270/Q23X8B2X |
More data for this
Ligand-Target Pair | |
Adenylate cyclase type 8
(Homo sapiens (Human)) | BDBM50604216
(CHEMBL5176001)Show SMILES CCc1cc(=O)[nH]c(n1)-n1nc(C)cc1NC(=O)c1cccc(OC)c1 | PDB
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| n/a | n/a | 9.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01759
BindingDB Entry DOI: 10.7270/Q29G5RWW |
More data for this
Ligand-Target Pair | |
Adenylate cyclase type 8
(Homo sapiens (Human)) | BDBM50521092
(CHEMBL4438060)Show SMILES COc1cc(cc(c1)C(F)(F)F)C(=O)Nc1nnc(o1)-c1ccc2CCCCc2c1 Show InChI InChI=1S/C21H18F3N3O3/c1-29-17-10-15(9-16(11-17)21(22,23)24)18(28)25-20-27-26-19(30-20)14-7-6-12-4-2-3-5-13(12)8-14/h6-11H,2-5H2,1H3,(H,25,27,28) | PDB
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| PC cid
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| Article
PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University
Curated by ChEMBL
| Assay Description
Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A2... |
Eur J Med Chem 162: 568-585 (2019)
Article DOI: 10.1016/j.ejmech.2018.11.036
BindingDB Entry DOI: 10.7270/Q23X8B2X |
More data for this
Ligand-Target Pair | |
Adenylate cyclase type 8
(Homo sapiens (Human)) | BDBM50604195
(CHEMBL5182341) | PDB
UniProtKB/SwissProt
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| PC cid
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| Article
PubMed
| n/a | n/a | 1.06E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01759
BindingDB Entry DOI: 10.7270/Q29G5RWW |
More data for this
Ligand-Target Pair | |
Adenylate cyclase type 8
(Homo sapiens (Human)) | BDBM50521070
(CHEMBL4547217)Show SMILES CC(C)Oc1ccc(cc1)C(=O)Nc1nnc(o1)-c1ccc2CCCCc2c1 Show InChI InChI=1S/C22H23N3O3/c1-14(2)27-19-11-9-16(10-12-19)20(26)23-22-25-24-21(28-22)18-8-7-15-5-3-4-6-17(15)13-18/h7-14H,3-6H2,1-2H3,(H,23,25,26) | PDB
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| PC cid
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PubMed
| n/a | n/a | 1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University
Curated by ChEMBL
| Assay Description
Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A2... |
Eur J Med Chem 162: 568-585 (2019)
Article DOI: 10.1016/j.ejmech.2018.11.036
BindingDB Entry DOI: 10.7270/Q23X8B2X |
More data for this
Ligand-Target Pair | |
Adenylate cyclase type 8
(Homo sapiens (Human)) | BDBM50521110
(CHEMBL4541956)Show SMILES CCOc1cccc2cc(oc12)-c1nnc(NC(=O)c2ccccc2SC)o1 Show InChI InChI=1S/C20H17N3O4S/c1-3-25-14-9-6-7-12-11-15(26-17(12)14)19-22-23-20(27-19)21-18(24)13-8-4-5-10-16(13)28-2/h4-11H,3H2,1-2H3,(H,21,23,24) | PDB
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| n/a | n/a | 1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University
Curated by ChEMBL
| Assay Description
Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A2... |
Eur J Med Chem 162: 568-585 (2019)
Article DOI: 10.1016/j.ejmech.2018.11.036
BindingDB Entry DOI: 10.7270/Q23X8B2X |
More data for this
Ligand-Target Pair | |
Adenylate cyclase type 8
(Homo sapiens (Human)) | BDBM64573
(MLS000529919 | N-(5-tetralin-6-yl-1,3,4-oxadiazol-...)Show InChI InChI=1S/C19H17N3O2/c23-17(14-7-2-1-3-8-14)20-19-22-21-18(24-19)16-11-10-13-6-4-5-9-15(13)12-16/h1-3,7-8,10-12H,4-6,9H2,(H,20,22,23) | PDB
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Similars
| Article
PubMed
| n/a | n/a | 1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University
Curated by ChEMBL
| Assay Description
Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A2... |
Eur J Med Chem 162: 568-585 (2019)
Article DOI: 10.1016/j.ejmech.2018.11.036
BindingDB Entry DOI: 10.7270/Q23X8B2X |
More data for this
Ligand-Target Pair | |
Adenylate cyclase type 8
(Homo sapiens (Human)) | BDBM50521102
(CHEMBL4582554)Show SMILES Cc1ccc(cc1C(F)(F)F)C(=O)Nc1nnc(o1)-c1ccc2CCCCc2c1 Show InChI InChI=1S/C21H18F3N3O2/c1-12-6-7-15(11-17(12)21(22,23)24)18(28)25-20-27-26-19(29-20)16-9-8-13-4-2-3-5-14(13)10-16/h6-11H,2-5H2,1H3,(H,25,27,28) | PDB
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| PC cid
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PubMed
| n/a | n/a | 1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University
Curated by ChEMBL
| Assay Description
Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A2... |
Eur J Med Chem 162: 568-585 (2019)
Article DOI: 10.1016/j.ejmech.2018.11.036
BindingDB Entry DOI: 10.7270/Q23X8B2X |
More data for this
Ligand-Target Pair | |
Adenylate cyclase type 8
(Homo sapiens (Human)) | BDBM50521078
(CHEMBL4518661)Show InChI InChI=1S/C19H17N3O4/c1-11-3-4-13(9-12(11)2)17(23)20-19-22-21-18(26-19)14-5-6-15-16(10-14)25-8-7-24-15/h3-6,9-10H,7-8H2,1-2H3,(H,20,22,23) | PDB
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PubMed
| n/a | n/a | 1.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University
Curated by ChEMBL
| Assay Description
Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A2... |
Eur J Med Chem 162: 568-585 (2019)
Article DOI: 10.1016/j.ejmech.2018.11.036
BindingDB Entry DOI: 10.7270/Q23X8B2X |
More data for this
Ligand-Target Pair | |
Adenylate cyclase type 8
(Homo sapiens (Human)) | BDBM50521104
(CHEMBL4531260)Show SMILES Cc1cc(cc(c1)C(F)(F)F)C(=O)Nc1nnc(o1)C1CCCCC1 Show InChI InChI=1S/C17H18F3N3O2/c1-10-7-12(9-13(8-10)17(18,19)20)14(24)21-16-23-22-15(25-16)11-5-3-2-4-6-11/h7-9,11H,2-6H2,1H3,(H,21,23,24) | PDB
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| PC cid
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UniChem
| Article
PubMed
| n/a | n/a | 1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University
Curated by ChEMBL
| Assay Description
Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A2... |
Eur J Med Chem 162: 568-585 (2019)
Article DOI: 10.1016/j.ejmech.2018.11.036
BindingDB Entry DOI: 10.7270/Q23X8B2X |
More data for this
Ligand-Target Pair | |
Adenylate cyclase type 8
(Homo sapiens (Human)) | BDBM50604196
(CHEMBL5193391)Show SMILES CCc1cc(=O)[nH]c(n1)-n1nc(C)cc1NC(=O)c1ccco1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.57E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01759
BindingDB Entry DOI: 10.7270/Q29G5RWW |
More data for this
Ligand-Target Pair | |
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