Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sphingosine 1-phosphate receptor 2 (Rattus norvegicus (Rat)) | BDBM149710 (US8975409, Example 38) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.2 | 37 |
ONO Pharmaceutical Co., Ltd. US Patent | Assay Description Chinese hamster ovary (CHO) cells overexpressing the human S1P2 gene were cultured in a Ham's F12 medium containing 10% fetal bovine serum (FBS), an ... | US Patent US8975409 (2015) BindingDB Entry DOI: 10.7270/Q2X34W60 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sphingosine 1-phosphate receptor 2 (Rattus norvegicus (Rat)) | BDBM149709 (US8975409, Example 19) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | 7.2 | 37 |
ONO Pharmaceutical Co., Ltd. US Patent | Assay Description Chinese hamster ovary (CHO) cells overexpressing the human S1P2 gene were cultured in a Ham's F12 medium containing 10% fetal bovine serum (FBS), an ... | US Patent US8975409 (2015) BindingDB Entry DOI: 10.7270/Q2X34W60 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sphingosine 1-phosphate receptor 2 (Rattus norvegicus (Rat)) | BDBM149712 (US8975409, Example 9) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | 7.2 | 37 |
ONO Pharmaceutical Co., Ltd. US Patent | Assay Description Chinese hamster ovary (CHO) cells overexpressing the human S1P2 gene were cultured in a Ham's F12 medium containing 10% fetal bovine serum (FBS), an ... | US Patent US8975409 (2015) BindingDB Entry DOI: 10.7270/Q2X34W60 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sphingosine 1-phosphate receptor 2 (Rattus norvegicus (Rat)) | BDBM149706 (US8975409, Example 13) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 3 | n/a | n/a | n/a | n/a | 7.2 | 37 |
ONO Pharmaceutical Co., Ltd. US Patent | Assay Description Chinese hamster ovary (CHO) cells overexpressing the human S1P2 gene were cultured in a Ham's F12 medium containing 10% fetal bovine serum (FBS), an ... | US Patent US8975409 (2015) BindingDB Entry DOI: 10.7270/Q2X34W60 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sphingosine 1-phosphate receptor 2 (Rattus norvegicus (Rat)) | BDBM149705 (US8975409, Example 9(3)) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | 7.2 | 37 |
ONO Pharmaceutical Co., Ltd. US Patent | Assay Description Chinese hamster ovary (CHO) cells overexpressing the human S1P2 gene were cultured in a Ham's F12 medium containing 10% fetal bovine serum (FBS), an ... | US Patent US8975409 (2015) BindingDB Entry DOI: 10.7270/Q2X34W60 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sphingosine 1-phosphate receptor 2 (Rattus norvegicus (Rat)) | BDBM149705 (US8975409, Example 9(3)) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Ono Pharmaceutical Co. Curated by ChEMBL | Assay Description Antagonist activity at rat S1P2 expressed in CHO cells assessed as Ca2+ level by FURA-2AM dye based fluorescence assay | Bioorg Med Chem Lett 25: 4387-92 (2015) Article DOI: 10.1016/j.bmcl.2015.09.022 BindingDB Entry DOI: 10.7270/Q2SX6G1K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sphingosine 1-phosphate receptor 2 (Rattus norvegicus (Rat)) | BDBM50120582 (CHEMBL3618199) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Ono Pharmaceutical Co. Curated by ChEMBL | Assay Description Antagonist activity at rat S1P2 expressed in CHO cells assessed as Ca2+ level by FURA-2AM dye based fluorescence assay | Bioorg Med Chem Lett 25: 4387-92 (2015) Article DOI: 10.1016/j.bmcl.2015.09.022 BindingDB Entry DOI: 10.7270/Q2SX6G1K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sphingosine 1-phosphate receptor 2 (Rattus norvegicus (Rat)) | BDBM50065611 (CHEMBL3401383) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Ono Pharmaceutical Co. Curated by ChEMBL | Assay Description Antagonist activity at rat S1P2 expressed in CHO cells assessed as Ca2+ level by FURA-2AM dye based fluorescence assay | Bioorg Med Chem Lett 25: 4387-92 (2015) Article DOI: 10.1016/j.bmcl.2015.09.022 BindingDB Entry DOI: 10.7270/Q2SX6G1K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sphingosine 1-phosphate receptor 2 (Rattus norvegicus (Rat)) | BDBM149708 (US8975409, Example 15(6)) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 5 | n/a | n/a | n/a | n/a | 7.2 | 37 |
ONO Pharmaceutical Co., Ltd. US Patent | Assay Description Chinese hamster ovary (CHO) cells overexpressing the human S1P2 gene were cultured in a Ham's F12 medium containing 10% fetal bovine serum (FBS), an ... | US Patent US8975409 (2015) BindingDB Entry DOI: 10.7270/Q2X34W60 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sphingosine 1-phosphate receptor 2 (Rattus norvegicus (Rat)) | BDBM50120583 (CHEMBL3618200) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Ono Pharmaceutical Co. Curated by ChEMBL | Assay Description Antagonist activity at rat S1P2 expressed in CHO cells assessed as Ca2+ level by FURA-2AM dye based fluorescence assay | Bioorg Med Chem Lett 25: 4387-92 (2015) Article DOI: 10.1016/j.bmcl.2015.09.022 BindingDB Entry DOI: 10.7270/Q2SX6G1K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sphingosine 1-phosphate receptor 2 (Rattus norvegicus (Rat)) | BDBM149707 (US8975409, Example 15(1)) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 9.60 | n/a | n/a | n/a | n/a | 7.2 | 37 |
ONO Pharmaceutical Co., Ltd. US Patent | Assay Description Chinese hamster ovary (CHO) cells overexpressing the human S1P2 gene were cultured in a Ham's F12 medium containing 10% fetal bovine serum (FBS), an ... | US Patent US8975409 (2015) BindingDB Entry DOI: 10.7270/Q2X34W60 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sphingosine 1-phosphate receptor 2 (Rattus norvegicus (Rat)) | BDBM50120579 (CHEMBL3618196) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Ono Pharmaceutical Co. Curated by ChEMBL | Assay Description Antagonist activity at rat S1P2 expressed in CHO cells assessed as Ca2+ level by FURA-2AM dye based fluorescence assay | Bioorg Med Chem Lett 25: 4387-92 (2015) Article DOI: 10.1016/j.bmcl.2015.09.022 BindingDB Entry DOI: 10.7270/Q2SX6G1K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sphingosine 1-phosphate receptor 2 (Rattus norvegicus (Rat)) | BDBM50120581 (CHEMBL3618198) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Ono Pharmaceutical Co. Curated by ChEMBL | Assay Description Antagonist activity at rat S1P2 expressed in CHO cells assessed as Ca2+ level by FURA-2AM dye based fluorescence assay | Bioorg Med Chem Lett 25: 4387-92 (2015) Article DOI: 10.1016/j.bmcl.2015.09.022 BindingDB Entry DOI: 10.7270/Q2SX6G1K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sphingosine 1-phosphate receptor 2 (Rattus norvegicus (Rat)) | BDBM50120580 (CHEMBL3618197) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Ono Pharmaceutical Co. Curated by ChEMBL | Assay Description Antagonist activity at rat S1P2 expressed in CHO cells assessed as Ca2+ level by FURA-2AM dye based fluorescence assay | Bioorg Med Chem Lett 25: 4387-92 (2015) Article DOI: 10.1016/j.bmcl.2015.09.022 BindingDB Entry DOI: 10.7270/Q2SX6G1K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sphingosine 1-phosphate receptor 2 (Rattus norvegicus (Rat)) | BDBM50065628 (CHEMBL1368758 | US9663511, Compound JTE013) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL) Curated by ChEMBL | Assay Description Antagonist activity at rat S1P2 receptor | J Med Chem 61: 9811-9840 (2018) Article DOI: 10.1021/acs.jmedchem.8b00294 BindingDB Entry DOI: 10.7270/Q2XK8J7N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sphingosine 1-phosphate receptor 2 (Rattus norvegicus (Rat)) | BDBM149711 (US8975409, Comparative compound B) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 27 | n/a | n/a | n/a | n/a | 7.2 | 37 |
ONO Pharmaceutical Co., Ltd. US Patent | Assay Description Chinese hamster ovary (CHO) cells overexpressing the human S1P2 gene were cultured in a Ham's F12 medium containing 10% fetal bovine serum (FBS), an ... | US Patent US8975409 (2015) BindingDB Entry DOI: 10.7270/Q2X34W60 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sphingosine 1-phosphate receptor 2 (Rattus norvegicus (Rat)) | BDBM50120513 (CHEMBL3618189) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 72 | n/a | n/a | n/a | n/a | n/a | n/a |
Ono Pharmaceutical Co. Curated by ChEMBL | Assay Description Antagonist activity at rat S1P2 expressed in CHO cells assessed as Ca2+ level by FURA-2AM dye based fluorescence assay | Bioorg Med Chem Lett 25: 4387-92 (2015) Article DOI: 10.1016/j.bmcl.2015.09.022 BindingDB Entry DOI: 10.7270/Q2SX6G1K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sphingosine 1-phosphate receptor 2 (Rattus norvegicus (Rat)) | BDBM149713 (US8975409, Comparative compound A) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 72 | n/a | n/a | n/a | n/a | 7.2 | 37 |
ONO Pharmaceutical Co., Ltd. US Patent | Assay Description Chinese hamster ovary (CHO) cells overexpressing the human S1P2 gene were cultured in a Ham's F12 medium containing 10% fetal bovine serum (FBS), an ... | US Patent US8975409 (2015) BindingDB Entry DOI: 10.7270/Q2X34W60 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sphingosine 1-phosphate receptor 2 (Rattus norvegicus (Rat)) | BDBM50120514 (CHEMBL3618190) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 690 | n/a | n/a | n/a | n/a | n/a | n/a |
Ono Pharmaceutical Co. Curated by ChEMBL | Assay Description Antagonist activity at rat S1P2 expressed in CHO cells assessed as Ca2+ level by FURA-2AM dye based fluorescence assay | Bioorg Med Chem Lett 25: 4387-92 (2015) Article DOI: 10.1016/j.bmcl.2015.09.022 BindingDB Entry DOI: 10.7270/Q2SX6G1K | |||||||||||
More data for this Ligand-Target Pair |