Found 6749 hits of ic50 data for polymerid = 694 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM286987
(8-(3-(4-acryloylpiperazin-1-yl)propyl)-2-((cyclopr...)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NCC3CC3)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O |(2.77,8.47,;4.1,7.7,;4.1,6.16,;5.44,5.39,;5.44,3.85,;6.77,3.08,;8.11,3.85,;4.1,3.08,;4.1,1.54,;2.77,3.85,;2.77,5.39,;1.44,6.16,;1.44,3.08,;.1,3.85,;-1.23,3.08,;-2.56,3.85,;-3.9,3.08,;-3.9,1.54,;-5.23,.77,;-5.23,-.77,;-6.57,-1.54,;-8.11,-1.54,;-7.34,-2.87,;-2.56,.77,;-1.23,1.54,;.1,.77,;.1,-.77,;1.44,-1.54,;1.44,-3.08,;2.77,-3.85,;2.77,-5.39,;4.1,-6.16,;5.44,-5.39,;5.44,-3.85,;4.1,-3.08,;6.77,-6.16,;8.11,-5.39,;6.77,-7.7,;8.11,-8.47,;1.44,1.54,;2.77,.77,)| Show InChI InChI=1S/C29H34Cl2N6O4/c1-4-23(38)36-12-10-35(11-13-36)8-5-9-37-27-19(17-33-29(34-27)32-16-18-6-7-18)14-20(28(37)39)24-25(30)21(40-2)15-22(41-3)26(24)31/h4,14-15,17-18H,1,5-13,16H2,2-3H3,(H,32,33,34) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2DB850W |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM286987
(8-(3-(4-acryloylpiperazin-1-yl)propyl)-2-((cyclopr...)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NCC3CC3)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O |(2.77,8.47,;4.1,7.7,;4.1,6.16,;5.44,5.39,;5.44,3.85,;6.77,3.08,;8.11,3.85,;4.1,3.08,;4.1,1.54,;2.77,3.85,;2.77,5.39,;1.44,6.16,;1.44,3.08,;.1,3.85,;-1.23,3.08,;-2.56,3.85,;-3.9,3.08,;-3.9,1.54,;-5.23,.77,;-5.23,-.77,;-6.57,-1.54,;-8.11,-1.54,;-7.34,-2.87,;-2.56,.77,;-1.23,1.54,;.1,.77,;.1,-.77,;1.44,-1.54,;1.44,-3.08,;2.77,-3.85,;2.77,-5.39,;4.1,-6.16,;5.44,-5.39,;5.44,-3.85,;4.1,-3.08,;6.77,-6.16,;8.11,-5.39,;6.77,-7.7,;8.11,-8.47,;1.44,1.54,;2.77,.77,)| Show InChI InChI=1S/C29H34Cl2N6O4/c1-4-23(38)36-12-10-35(11-13-36)8-5-9-37-27-19(17-33-29(34-27)32-16-18-6-7-18)14-20(28(37)39)24-25(30)21(40-2)15-22(41-3)26(24)31/h4,14-15,17-18H,1,5-13,16H2,2-3H3,(H,32,33,34) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | 25 |
Principia Biopharma, Inc.
US Patent
| Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin... |
US Patent US9567334 (2017)
BindingDB Entry DOI: 10.7270/Q2XK8HKQ |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM286987
(8-(3-(4-acryloylpiperazin-1-yl)propyl)-2-((cyclopr...)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NCC3CC3)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O |(2.77,8.47,;4.1,7.7,;4.1,6.16,;5.44,5.39,;5.44,3.85,;6.77,3.08,;8.11,3.85,;4.1,3.08,;4.1,1.54,;2.77,3.85,;2.77,5.39,;1.44,6.16,;1.44,3.08,;.1,3.85,;-1.23,3.08,;-2.56,3.85,;-3.9,3.08,;-3.9,1.54,;-5.23,.77,;-5.23,-.77,;-6.57,-1.54,;-8.11,-1.54,;-7.34,-2.87,;-2.56,.77,;-1.23,1.54,;.1,.77,;.1,-.77,;1.44,-1.54,;1.44,-3.08,;2.77,-3.85,;2.77,-5.39,;4.1,-6.16,;5.44,-5.39,;5.44,-3.85,;4.1,-3.08,;6.77,-6.16,;8.11,-5.39,;6.77,-7.7,;8.11,-8.47,;1.44,1.54,;2.77,.77,)| Show InChI InChI=1S/C29H34Cl2N6O4/c1-4-23(38)36-12-10-35(11-13-36)8-5-9-37-27-19(17-33-29(34-27)32-16-18-6-7-18)14-20(28(37)39)24-25(30)21(40-2)15-22(41-3)26(24)31/h4,14-15,17-18H,1,5-13,16H2,2-3H3,(H,32,33,34) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc.
| Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin... |
Bioorg Med Chem Lett 19: 773-7 (2009)
BindingDB Entry DOI: 10.7270/Q2GX4DVZ |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM301217
(3-(2,6-Difluoro-3,5-dimethoxyphenyl)-1-methyl-1,3,...)Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]ccc4c3N(C)C2=O)c1F Show InChI InChI=1S/C18H16F2N4O3/c1-23-15-9(7-22-17-10(15)4-5-21-17)8-24(18(23)25)16-13(19)11(26-2)6-12(27-3)14(16)20/h4-7H,8H2,1-3H3,(H,21,22) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.120 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human FGFR1 using biotinylated-EQEDEPEGDYFEWLE peptide as substrate incubated for 1 hr in presence of ATP by FRET assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00713 BindingDB Entry DOI: 10.7270/Q2S1867R |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM301220
(3-(2-Chloro-6-fluoro-3,5-dimethoxyphenyl)-1-methyl...)Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc4[nH]ccc4c3N(C)C2=O)c1F Show InChI InChI=1S/C18H16ClFN4O3/c1-23-15-9(7-22-17-10(15)4-5-21-17)8-24(18(23)25)16-13(19)11(26-2)6-12(27-3)14(16)20/h4-7H,8H2,1-3H3,(H,21,22) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.170 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human FGFR1 using biotinylated-EQEDEPEGDYFEWLE peptide as substrate incubated for 1 hr in presence of ATP by FRET assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00713 BindingDB Entry DOI: 10.7270/Q2S1867R |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50602226
(CHEMBL5177696)Show SMILES COc1cc(OC)cc(c1)N(CCNC(C)C)c1ccc2ncc(nc2c1)-c1cnn(CCCCCCC(=O)NO)c1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.180 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01413 BindingDB Entry DOI: 10.7270/Q25D8WX6 |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50065454
(CHEBI:63453 | CHEMBL3348846)Show SMILES COc1cc(CCc2cc(NC(=O)c3ccc(cc3)N3C[C@H](C)N[C@H](C)C3)n[nH]2)cc(OC)c1 Show InChI InChI=1S/C26H33N5O3/c1-17-15-31(16-18(2)27-17)22-9-6-20(7-10-22)26(32)28-25-13-21(29-30-25)8-5-19-11-23(33-3)14-24(12-19)34-4/h6-7,9-14,17-18,27H,5,8,15-16H2,1-4H3,(H2,28,29,30,32)/t17-,18+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112990 BindingDB Entry DOI: 10.7270/Q2WD44HQ |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50588744
(CHEMBL5189383)Show SMILES COc1cc(OC)cc(c1)N(CCNC(C)C)c1ccc2nc(cnc2c1)-c1cnn(C)c1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01366 BindingDB Entry DOI: 10.7270/Q2PG1WPR |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50065454
(CHEBI:63453 | CHEMBL3348846)Show SMILES COc1cc(CCc2cc(NC(=O)c3ccc(cc3)N3C[C@H](C)N[C@H](C)C3)n[nH]2)cc(OC)c1 Show InChI InChI=1S/C26H33N5O3/c1-17-15-31(16-18(2)27-17)22-9-6-20(7-10-22)26(32)28-25-13-21(29-30-25)8-5-19-11-23(33-3)14-24(12-19)34-4/h6-7,9-14,17-18,27H,5,8,15-16H2,1-4H3,(H2,28,29,30,32)/t17-,18+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Materia Medica
Curated by ChEMBL
| Assay Description Inhibition of human FGFR1 |
ACS Med Chem Lett 7: 629-34 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00066 BindingDB Entry DOI: 10.7270/Q2P272M2 |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50532674
(CHEMBL4557949)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(cc3)N3CCN(CC3)C3CCC3)n[nH]c2n1 Show InChI InChI=1S/C29H30Cl2N6O3/c1-39-22-16-23(40-2)26(31)24(25(22)30)21-11-10-20-27(32-21)34-35-28(20)33-29(38)17-6-8-19(9-7-17)37-14-12-36(13-15-37)18-4-3-5-18/h6-11,16,18H,3-5,12-15H2,1-2H3,(H2,32,33,34,35,38) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Materia Medica
Curated by ChEMBL
| Assay Description Inhibition of recombinant human FGFR1 using poly (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISA |
ACS Med Chem Lett 7: 629-34 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00066 BindingDB Entry DOI: 10.7270/Q2P272M2 |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50065454
(CHEBI:63453 | CHEMBL3348846)Show SMILES COc1cc(CCc2cc(NC(=O)c3ccc(cc3)N3C[C@H](C)N[C@H](C)C3)n[nH]2)cc(OC)c1 Show InChI InChI=1S/C26H33N5O3/c1-17-15-31(16-18(2)27-17)22-9-6-20(7-10-22)26(32)28-25-13-21(29-30-25)8-5-19-11-23(33-3)14-24(12-19)34-4/h6-7,9-14,17-18,27H,5,8,15-16H2,1-4H3,(H2,28,29,30,32)/t17-,18+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Materia Medica
Curated by ChEMBL
| Assay Description Inhibition of human FGFR1 |
ACS Med Chem Lett 7: 629-34 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00066 BindingDB Entry DOI: 10.7270/Q2P272M2 |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50532674
(CHEMBL4557949)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(cc3)N3CCN(CC3)C3CCC3)n[nH]c2n1 Show InChI InChI=1S/C29H30Cl2N6O3/c1-39-22-16-23(40-2)26(31)24(25(22)30)21-11-10-20-27(32-21)34-35-28(20)33-29(38)17-6-8-19(9-7-17)37-14-12-36(13-15-37)18-4-3-5-18/h6-11,16,18H,3-5,12-15H2,1-2H3,(H2,32,33,34,35,38) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Materia Medica
Curated by ChEMBL
| Assay Description Inhibition of recombinant human FGFR1 using poly (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISA |
ACS Med Chem Lett 7: 629-34 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00066 BindingDB Entry DOI: 10.7270/Q2P272M2 |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50065454
(CHEBI:63453 | CHEMBL3348846)Show SMILES COc1cc(CCc2cc(NC(=O)c3ccc(cc3)N3C[C@H](C)N[C@H](C)C3)n[nH]2)cc(OC)c1 Show InChI InChI=1S/C26H33N5O3/c1-17-15-31(16-18(2)27-17)22-9-6-20(7-10-22)26(32)28-25-13-21(29-30-25)8-5-19-11-23(33-3)14-24(12-19)34-4/h6-7,9-14,17-18,27H,5,8,15-16H2,1-4H3,(H2,28,29,30,32)/t17-,18+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human FGFR1 in presence of ATP |
Eur J Med Chem 126: 476-490 (2017)
Article DOI: 10.1016/j.ejmech.2016.11.052 BindingDB Entry DOI: 10.7270/Q2445PQT |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50532684
(CHEMBL4542061)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(cc3)N3CCN(CC3)S(C)(=O)=O)n[nH]c2n1 Show InChI InChI=1S/C26H26Cl2N6O5S/c1-38-19-14-20(39-2)23(28)21(22(19)27)18-9-8-17-24(29-18)31-32-25(17)30-26(35)15-4-6-16(7-5-15)33-10-12-34(13-11-33)40(3,36)37/h4-9,14H,10-13H2,1-3H3,(H2,29,30,31,32,35) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Materia Medica
Curated by ChEMBL
| Assay Description Inhibition of recombinant human FGFR1 using poly (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISA |
ACS Med Chem Lett 7: 629-34 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00066 BindingDB Entry DOI: 10.7270/Q2P272M2 |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50065454
(CHEBI:63453 | CHEMBL3348846)Show SMILES COc1cc(CCc2cc(NC(=O)c3ccc(cc3)N3C[C@H](C)N[C@H](C)C3)n[nH]2)cc(OC)c1 Show InChI InChI=1S/C26H33N5O3/c1-17-15-31(16-18(2)27-17)22-9-6-20(7-10-22)26(32)28-25-13-21(29-30-25)8-5-19-11-23(33-3)14-24(12-19)34-4/h6-7,9-14,17-18,27H,5,8,15-16H2,1-4H3,(H2,28,29,30,32)/t17-,18+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human FGFR1 in presence of ATP at Km concentration |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113499 BindingDB Entry DOI: 10.7270/Q2HH6PWN |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50166610
(CHEMBL3800526)Show SMILES COc1cc(CCc2cc(Nc3ncnc4cc(ccc34)N3CCN4CCCCC4C3)n[nH]2)cc(OC)c1 Show InChI InChI=1S/C29H35N7O2/c1-37-24-13-20(14-25(17-24)38-2)6-7-21-15-28(34-33-21)32-29-26-9-8-22(16-27(26)30-19-31-29)36-12-11-35-10-4-3-5-23(35)18-36/h8-9,13-17,19,23H,3-7,10-12,18H2,1-2H3,(H2,30,31,32,33,34) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | <0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences (CAS)
Curated by ChEMBL
| Assay Description Inhibition of FGFR1 in human KG1 cells assessed as suppression of cell proliferation after 72 hrs by SRB/CCK-8 assay |
Bioorg Med Chem Lett 26: 2594-9 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.028 BindingDB Entry DOI: 10.7270/Q20C4XNM |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50065454
(CHEBI:63453 | CHEMBL3348846)Show SMILES COc1cc(CCc2cc(NC(=O)c3ccc(cc3)N3C[C@H](C)N[C@H](C)C3)n[nH]2)cc(OC)c1 Show InChI InChI=1S/C26H33N5O3/c1-17-15-31(16-18(2)27-17)22-9-6-20(7-10-22)26(32)28-25-13-21(29-30-25)8-5-19-11-23(33-3)14-24(12-19)34-4/h6-7,9-14,17-18,27H,5,8,15-16H2,1-4H3,(H2,28,29,30,32)/t17-,18+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | <0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences (CAS)
Curated by ChEMBL
| Assay Description Inhibition of FGFR1 in human KG1 cells assessed as suppression of cell proliferation after 72 hrs by SRB/CCK-8 assay |
Bioorg Med Chem Lett 26: 2594-9 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.028 BindingDB Entry DOI: 10.7270/Q20C4XNM |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50189870
(CHEMBL3827818)Show SMILES CC(Oc1ccc2[nH]nc(-c3nc4cc(ccc4[nH]3)N3CCOCC3)c2c1)c1c(Cl)cncc1Cl Show InChI InChI=1S/C25H22Cl2N6O2/c1-14(23-18(26)12-28-13-19(23)27)35-16-3-5-20-17(11-16)24(32-31-20)25-29-21-4-2-15(10-22(21)30-25)33-6-8-34-9-7-33/h2-5,10-14H,6-9H2,1H3,(H,29,30)(H,31,32) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
East China University of Science& Technology
Curated by ChEMBL
| Assay Description Inhibition of recombinant human FGFR1 using poly (Glu, Tyr) 4:1 as substrate after 60 mins by ELISA |
J Med Chem 59: 6690-708 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00056 BindingDB Entry DOI: 10.7270/Q2474CT3 |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM302362
(6-[(2-Aminoethoxy)methyl]-5-(7-methoxy-5-methyl-1-...)Show SMILES COc1cc(C)cc2cc(sc12)-c1c(COCCN)cn2ncnc(N)c12 Show InChI InChI=1S/C19H21N5O2S/c1-11-5-12-7-15(27-18(12)14(6-11)25-2)16-13(9-26-4-3-20)8-24-17(16)19(21)22-10-23-24/h5-8,10H,3-4,9,20H2,1-2H3,(H2,21,22,23) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
BAYER INTELLECTUAL PROPERTY GMBH
US Patent
| Assay Description Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM... |
US Patent US9598416 (2017)
BindingDB Entry DOI: 10.7270/Q2Q2428R |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50532684
(CHEMBL4542061)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(cc3)N3CCN(CC3)S(C)(=O)=O)n[nH]c2n1 Show InChI InChI=1S/C26H26Cl2N6O5S/c1-38-19-14-20(39-2)23(28)21(22(19)27)18-9-8-17-24(29-18)31-32-25(17)30-26(35)15-4-6-16(7-5-15)33-10-12-34(13-11-33)40(3,36)37/h4-9,14H,10-13H2,1-3H3,(H2,29,30,31,32,35) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Materia Medica
Curated by ChEMBL
| Assay Description Inhibition of recombinant human FGFR1 using poly (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISA |
ACS Med Chem Lett 7: 629-34 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00066 BindingDB Entry DOI: 10.7270/Q2P272M2 |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50602224
(CHEMBL5178408)Show SMILES COc1cc(OC)cc(c1)N(CCNC(C)C)c1ccc2ncc(nc2c1)-c1cnn(CCCCC(=O)NO)c1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.230 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01413 BindingDB Entry DOI: 10.7270/Q25D8WX6 |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50602229
(CHEMBL5181688)Show SMILES COc1cc(OC)cc(c1)N(CCNC(C)C)c1ccc2ncc(nc2c1)-c1cnn(CCOc2ccc(cc2)C(=O)NO)c1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.240 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01413 BindingDB Entry DOI: 10.7270/Q25D8WX6 |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50602225
(CHEMBL5187998)Show SMILES COc1cc(OC)cc(c1)N(CCNC(C)C)c1ccc2ncc(nc2c1)-c1cnn(CCCCCC(=O)NO)c1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.240 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01413 BindingDB Entry DOI: 10.7270/Q25D8WX6 |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50602223
(CHEMBL5186645)Show SMILES COc1cc(OC)cc(c1)N(CCNC(C)C)c1ccc2ncc(nc2c1)-c1cnn(CCCC(=O)NO)c1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.25 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01413 BindingDB Entry DOI: 10.7270/Q25D8WX6 |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50602227
(CHEMBL5202576)Show SMILES COc1cc(OC)cc(c1)N(CCNC(C)C)c1ccc2ncc(nc2c1)-c1cnn(CCCCCCCC(=O)NO)c1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.260 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01413 BindingDB Entry DOI: 10.7270/Q25D8WX6 |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50602235
(CHEMBL5186714)Show SMILES COc1cc(OC)cc(c1)N(CCNC(C)C)c1ccc2ncc(nc2c1)-c1cnn(Cc2cccc(c2)C(=O)NO)c1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.270 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01413 BindingDB Entry DOI: 10.7270/Q25D8WX6 |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50260190
(CHEMBL4100258)Show SMILES COc1ccc(Nc2ncc3CN(C(=O)N(C4CCN(CC4)C(=O)\C=C\CN(C)C)c3n2)c2c(Cl)c(OC)cc(OC)c2Cl)cc1 Show InChI InChI=1S/C32H37Cl2N7O5/c1-38(2)14-6-7-26(42)39-15-12-22(13-16-39)41-30-20(18-35-31(37-30)36-21-8-10-23(44-3)11-9-21)19-40(32(41)43)29-27(33)24(45-4)17-25(46-5)28(29)34/h6-11,17-18,22H,12-16,19H2,1-5H3,(H,35,36,37)/b7-6+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.280 | n/a | n/a | n/a | n/a | n/a | n/a |
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
| Assay Description Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ... |
Eur J Med Chem 135: 531-543 (2017)
Article DOI: 10.1016/j.ejmech.2017.04.049 BindingDB Entry DOI: 10.7270/Q2K076QF |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50602222
(CHEMBL5182360)Show SMILES COc1cc(OC)cc(c1)N(CCNC(C)C)c1ccc2ncc(nc2c1)-c1cnn(CCC(=O)NO)c1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.280 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01413 BindingDB Entry DOI: 10.7270/Q25D8WX6 |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50611354
(CHEMBL5271030) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | <0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM302404
(US9598416, Example 50)Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CCN(C)CC2)cn2ncnc(N)c12 Show InChI InChI=1S/C22H26N6OS/c1-14-8-15-10-18(30-21(15)17(9-14)29-3)19-16(11-27-6-4-26(2)5-7-27)12-28-20(19)22(23)24-13-25-28/h8-10,12-13H,4-7,11H2,1-3H3,(H2,23,24,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
BAYER INTELLECTUAL PROPERTY GMBH
US Patent
| Assay Description Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM... |
US Patent US9598416 (2017)
BindingDB Entry DOI: 10.7270/Q2Q2428R |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50532662
(CHEMBL4447575)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(cc3)N3CCN(CC3)C(C)=O)n[nH]c2n1 Show InChI InChI=1S/C27H26Cl2N6O4/c1-15(36)34-10-12-35(13-11-34)17-6-4-16(5-7-17)27(37)31-26-18-8-9-19(30-25(18)32-33-26)22-23(28)20(38-2)14-21(39-3)24(22)29/h4-9,14H,10-13H2,1-3H3,(H2,30,31,32,33,37) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Materia Medica
Curated by ChEMBL
| Assay Description Inhibition of recombinant human FGFR1 using poly (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISA |
ACS Med Chem Lett 7: 629-34 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00066 BindingDB Entry DOI: 10.7270/Q2P272M2 |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50532673
(CHEMBL4447359)Show SMILES COCCN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2nc(ccc12)-c1c(Cl)c(OC)cc(OC)c1Cl Show InChI InChI=1S/C28H30Cl2N6O4/c1-38-15-14-35-10-12-36(13-11-35)18-6-4-17(5-7-18)28(37)32-27-19-8-9-20(31-26(19)33-34-27)23-24(29)21(39-2)16-22(40-3)25(23)30/h4-9,16H,10-15H2,1-3H3,(H2,31,32,33,34,37) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Materia Medica
Curated by ChEMBL
| Assay Description Inhibition of recombinant human FGFR1 using poly (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISA |
ACS Med Chem Lett 7: 629-34 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00066 BindingDB Entry DOI: 10.7270/Q2P272M2 |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50532680
(CHEMBL4553127)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(cc3)N3CCN(CCO)CC3)n[nH]c2n1 Show InChI InChI=1S/C27H28Cl2N6O4/c1-38-20-15-21(39-2)24(29)22(23(20)28)19-8-7-18-25(30-19)32-33-26(18)31-27(37)16-3-5-17(6-4-16)35-11-9-34(10-12-35)13-14-36/h3-8,15,36H,9-14H2,1-2H3,(H2,30,31,32,33,37) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Materia Medica
Curated by ChEMBL
| Assay Description Inhibition of recombinant human FGFR1 using poly (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISA |
ACS Med Chem Lett 7: 629-34 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00066 BindingDB Entry DOI: 10.7270/Q2P272M2 |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50532673
(CHEMBL4447359)Show SMILES COCCN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2nc(ccc12)-c1c(Cl)c(OC)cc(OC)c1Cl Show InChI InChI=1S/C28H30Cl2N6O4/c1-38-15-14-35-10-12-36(13-11-35)18-6-4-17(5-7-18)28(37)32-27-19-8-9-20(31-26(19)33-34-27)23-24(29)21(39-2)16-22(40-3)25(23)30/h4-9,16H,10-15H2,1-3H3,(H2,31,32,33,34,37) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Materia Medica
Curated by ChEMBL
| Assay Description Inhibition of recombinant human FGFR1 using poly (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISA |
ACS Med Chem Lett 7: 629-34 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00066 BindingDB Entry DOI: 10.7270/Q2P272M2 |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50532680
(CHEMBL4553127)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(cc3)N3CCN(CCO)CC3)n[nH]c2n1 Show InChI InChI=1S/C27H28Cl2N6O4/c1-38-20-15-21(39-2)24(29)22(23(20)28)19-8-7-18-25(30-19)32-33-26(18)31-27(37)16-3-5-17(6-4-16)35-11-9-34(10-12-35)13-14-36/h3-8,15,36H,9-14H2,1-2H3,(H2,30,31,32,33,37) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Materia Medica
Curated by ChEMBL
| Assay Description Inhibition of recombinant human FGFR1 using poly (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISA |
ACS Med Chem Lett 7: 629-34 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00066 BindingDB Entry DOI: 10.7270/Q2P272M2 |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM286978
(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2-chloro...)Show SMILES COc1cc(OC)c(Cl)c(c1)-c1cc2cnc(NCC(C)(C)O)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O Show InChI InChI=1S/C29H37ClN6O5/c1-6-24(37)35-12-10-34(11-13-35)8-7-9-36-26-19(17-31-28(33-26)32-18-29(2,3)39)14-22(27(36)38)21-15-20(40-4)16-23(41-5)25(21)30/h6,14-17,39H,1,7-13,18H2,2-5H3,(H,31,32,33) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2DB850W |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM286978
(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2-chloro...)Show SMILES COc1cc(OC)c(Cl)c(c1)-c1cc2cnc(NCC(C)(C)O)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O Show InChI InChI=1S/C29H37ClN6O5/c1-6-24(37)35-12-10-34(11-13-35)8-7-9-36-26-19(17-31-28(33-26)32-18-29(2,3)39)14-22(27(36)38)21-15-20(40-4)16-23(41-5)25(21)30/h6,14-17,39H,1,7-13,18H2,2-5H3,(H,31,32,33) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc.
| Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin... |
Bioorg Med Chem Lett 19: 773-7 (2009)
BindingDB Entry DOI: 10.7270/Q2GX4DVZ |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50189781
(CHEMBL3828009)Show SMILES C[C@@H](Oc1ccc2[nH]nc(\C=C\c3cnn(CCO)c3)c2c1)c1c(Cl)cncc1Cl |r| Show InChI InChI=1S/C21H19Cl2N5O2/c1-13(21-17(22)10-24-11-18(21)23)30-15-3-5-20-16(8-15)19(26-27-20)4-2-14-9-25-28(12-14)6-7-29/h2-5,8-13,29H,6-7H2,1H3,(H,26,27)/b4-2+/t13-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of recombinant FGFR1 (unknown origin) using poly (Glu,Tyr) 4:1 as substrate after 60 mins by ELISA |
J Med Chem 61: 9085-9104 (2018)
Article DOI: 10.1021/acs.jmedchem.7b01843 BindingDB Entry DOI: 10.7270/Q2RR22N4 |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50520607
(CHEMBL4461734)Show SMILES COc1cc(C)cc2cc(sc12)-c1cn(C2CCN(C2)C(=O)C#C)c2ncnc(N)c12 Show InChI InChI=1S/C23H21N5O2S/c1-4-19(29)27-6-5-15(10-27)28-11-16(20-22(24)25-12-26-23(20)28)18-9-14-7-13(2)8-17(30-3)21(14)31-18/h1,7-9,11-12,15H,5-6,10H2,2-3H3,(H2,24,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of recombinant FGFR1 (unknown origin) using poly (Glu,Tyr) 4:1 as substrate after 60 mins by ELISA |
J Med Chem 61: 9085-9104 (2018)
Article DOI: 10.1021/acs.jmedchem.7b01843 BindingDB Entry DOI: 10.7270/Q2RR22N4 |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50520608
(CHEMBL4438578)Show SMILES COc1cc(C)cc2cc(sc12)-c1cn(C2CN(C2)S(=O)(=O)C=C)c2ncnc(N)c12 Show InChI InChI=1S/C21H21N5O3S2/c1-4-31(27,28)25-8-14(9-25)26-10-15(18-20(22)23-11-24-21(18)26)17-7-13-5-12(2)6-16(29-3)19(13)30-17/h4-7,10-11,14H,1,8-9H2,2-3H3,(H2,22,23,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | <0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of recombinant FGFR1 (unknown origin) using poly (Glu,Tyr) 4:1 as substrate after 60 mins by ELISA |
J Med Chem 61: 9085-9104 (2018)
Article DOI: 10.1021/acs.jmedchem.7b01843 BindingDB Entry DOI: 10.7270/Q2RR22N4 |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50520598
(CHEMBL4560984)Show SMILES COc1cc(C)cc2cc(sc12)-c1cn(C2CCN(C2)C(=O)C=C)c2ncnc(N)c12 Show InChI InChI=1S/C23H23N5O2S/c1-4-19(29)27-6-5-15(10-27)28-11-16(20-22(24)25-12-26-23(20)28)18-9-14-7-13(2)8-17(30-3)21(14)31-18/h4,7-9,11-12,15H,1,5-6,10H2,2-3H3,(H2,24,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | <0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of recombinant FGFR1 (unknown origin) using poly (Glu,Tyr) 4:1 as substrate after 60 mins by ELISA |
J Med Chem 61: 9085-9104 (2018)
Article DOI: 10.1021/acs.jmedchem.7b01843 BindingDB Entry DOI: 10.7270/Q2RR22N4 |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50520597
(CHEMBL4475243)Show SMILES COc1cc(C)cc2cc(sc12)-c1cn([C@H]2CCN(C2)C(=O)C=C)c2ncnc(N)c12 |r| Show InChI InChI=1S/C23H23N5O2S/c1-4-19(29)27-6-5-15(10-27)28-11-16(20-22(24)25-12-26-23(20)28)18-9-14-7-13(2)8-17(30-3)21(14)31-18/h4,7-9,11-12,15H,1,5-6,10H2,2-3H3,(H2,24,25,26)/t15-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | <0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of recombinant FGFR1 (unknown origin) using poly (Glu,Tyr) 4:1 as substrate after 60 mins by ELISA |
J Med Chem 61: 9085-9104 (2018)
Article DOI: 10.1021/acs.jmedchem.7b01843 BindingDB Entry DOI: 10.7270/Q2RR22N4 |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50532662
(CHEMBL4447575)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(cc3)N3CCN(CC3)C(C)=O)n[nH]c2n1 Show InChI InChI=1S/C27H26Cl2N6O4/c1-15(36)34-10-12-35(13-11-34)17-6-4-16(5-7-17)27(37)31-26-18-8-9-19(30-25(18)32-33-26)22-23(28)20(38-2)14-21(39-3)24(22)29/h4-9,14H,10-13H2,1-3H3,(H2,30,31,32,33,37) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Materia Medica
Curated by ChEMBL
| Assay Description Inhibition of recombinant human FGFR1 using poly (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISA |
ACS Med Chem Lett 7: 629-34 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00066 BindingDB Entry DOI: 10.7270/Q2P272M2 |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM434566
(US10562900, Example 63)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(cc3)N3CCN(C)CC3)n[nH]c2n1 Show InChI InChI=1S/C26H26Cl2N6O3/c1-33-10-12-34(13-11-33)16-6-4-15(5-7-16)26(35)30-25-17-8-9-18(29-24(17)31-32-25)21-22(27)19(36-2)14-20(37-3)23(21)28/h4-9,14H,10-13H2,1-3H3,(H2,29,30,31,32,35) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Materia Medica
Curated by ChEMBL
| Assay Description Inhibition of recombinant human FGFR1 using poly (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISA |
ACS Med Chem Lett 7: 629-34 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00066 BindingDB Entry DOI: 10.7270/Q2P272M2 |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50189781
(CHEMBL3828009)Show SMILES C[C@@H](Oc1ccc2[nH]nc(\C=C\c3cnn(CCO)c3)c2c1)c1c(Cl)cncc1Cl |r| Show InChI InChI=1S/C21H19Cl2N5O2/c1-13(21-17(22)10-24-11-18(21)23)30-15-3-5-20-16(8-15)19(26-27-20)4-2-14-9-25-28(12-14)6-7-29/h2-5,8-13,29H,6-7H2,1H3,(H,26,27)/b4-2+/t13-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
East China University of Science& Technology
Curated by ChEMBL
| Assay Description Inhibition of recombinant human FGFR1 using poly (Glu, Tyr) 4:1 as substrate after 60 mins by ELISA |
J Med Chem 59: 6690-708 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00056 BindingDB Entry DOI: 10.7270/Q2474CT3 |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50189872
(CHEMBL3827492)Show SMILES CC(Oc1ccc2[nH]nc(-c3nc4cc(NCCN(C)C)ccc4[nH]3)c2c1)c1c(Cl)cncc1Cl Show InChI InChI=1S/C25H25Cl2N7O/c1-14(23-18(26)12-28-13-19(23)27)35-16-5-7-20-17(11-16)24(33-32-20)25-30-21-6-4-15(10-22(21)31-25)29-8-9-34(2)3/h4-7,10-14,29H,8-9H2,1-3H3,(H,30,31)(H,32,33) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
East China University of Science& Technology
Curated by ChEMBL
| Assay Description Inhibition of recombinant human FGFR1 using poly (Glu, Tyr) 4:1 as substrate after 60 mins by ELISA |
J Med Chem 59: 6690-708 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00056 BindingDB Entry DOI: 10.7270/Q2474CT3 |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM286978
(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2-chloro...)Show SMILES COc1cc(OC)c(Cl)c(c1)-c1cc2cnc(NCC(C)(C)O)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O Show InChI InChI=1S/C29H37ClN6O5/c1-6-24(37)35-12-10-34(11-13-35)8-7-9-36-26-19(17-31-28(33-26)32-18-29(2,3)39)14-22(27(36)38)21-15-20(40-4)16-23(41-5)25(21)30/h6,14-17,39H,1,7-13,18H2,2-5H3,(H,31,32,33) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | 25 |
Principia Biopharma, Inc.
US Patent
| Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin... |
US Patent US9567334 (2017)
BindingDB Entry DOI: 10.7270/Q2XK8HKQ |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM434566
(US10562900, Example 63)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(cc3)N3CCN(C)CC3)n[nH]c2n1 Show InChI InChI=1S/C26H26Cl2N6O3/c1-33-10-12-34(13-11-33)16-6-4-15(5-7-16)26(35)30-25-17-8-9-18(29-24(17)31-32-25)21-22(27)19(36-2)14-20(37-3)23(21)28/h4-9,14H,10-13H2,1-3H3,(H2,29,30,31,32,35) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Materia Medica
Curated by ChEMBL
| Assay Description Inhibition of recombinant human FGFR1 using poly (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISA |
ACS Med Chem Lett 7: 629-34 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00066 BindingDB Entry DOI: 10.7270/Q2P272M2 |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50602228
(CHEMBL5191744)Show SMILES COc1cc(OC)cc(c1)N(CCNC(C)C)c1ccc2ncc(nc2c1)-c1cnn(CCCCCCCCC(=O)NO)c1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.320 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01413 BindingDB Entry DOI: 10.7270/Q25D8WX6 |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM130859
(US8829199, 114)Show SMILES CC1CCC(C)N1Cc1ccc2[nH]c(cc2c1)C(=O)c1cnn(c1N)-c1ccc2nc(C)nc2c1 Show InChI InChI=1S/C27H29N7O/c1-15-4-5-16(2)33(15)14-18-6-8-22-19(10-18)11-25(32-22)26(35)21-13-29-34(27(21)28)20-7-9-23-24(12-20)31-17(3)30-23/h6-13,15-16,32H,4-5,14,28H2,1-3H3,(H,30,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 0.320 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG
US Patent
| Assay Description The FGFR1-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma... |
US Patent US8829199 (2014)
BindingDB Entry DOI: 10.7270/Q26T0KB8 |
More data for this Ligand-Target Pair | |