Compile Data Set for Download or QSAR

Found 435 hits of ic50 for UniProtKB: P26662   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Genome polyprotein (Hepatitis C Virus (Virus))	BDBM208164 (US9265773, 107 | US9265773, 108) Show SMILES CCNC(=O)C1Oc2ccc(nc2-c2cc3c(F)cccc3n12)-c1cc2c(C(=O)NC)c(oc2cc1N(C)S(C)(=O)=O)-c1ccc(F)cc1 Show InChI InChI=1S/C35H29F2N5O6S/c1-5-39-34(44)35-42-25-8-6-7-23(37)20(25)16-27(42)31-28(48-35)14-13-24(40-31)21-15-22-29(17-26(21)41(3)49(4,45)46)47-32(30(22)33(43)38-2)18-9-11-19(36)12-10-18/h6-17,35H,5H2,1-4H3,(H,38,43)(H,39,44)	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD Italia S.R.L. US Patent					Assay Description Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...				US Patent US9265773 (2016) BindingDB Entry DOI: 10.7270/Q2XD10H7
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C Virus (Virus))	BDBM208184 (US9265773, 128) Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ccc2OC(CNS(C)(=O)=O)n3c(cc4c(F)cccc34)-c2n1)-c1ccc(F)cc1 Show InChI InChI=1S/C34H29F2N5O7S2/c1-37-34(42)31-22-14-21(26(40(2)50(4,45)46)16-29(22)48-33(31)18-8-10-19(35)11-9-18)24-12-13-28-32(39-24)27-15-20-23(36)6-5-7-25(20)41(27)30(47-28)17-38-49(3,43)44/h5-16,30,38H,17H2,1-4H3,(H,37,42)	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD Italia S.R.L. US Patent					Assay Description Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...				US Patent US9265773 (2016) BindingDB Entry DOI: 10.7270/Q2XD10H7
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C Virus (Virus))	BDBM208146 (US9265773, 89 | US9265773, 90) Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1cc2-c3cc4c(F)cccc4n3C(CO)Oc2cn1)-c1ccc(F)cc1 Show InChI InChI=1S/C33H26F2N4O6S/c1-36-33(41)31-22-11-20(26(38(2)46(3,42)43)14-28(22)45-32(31)17-7-9-18(34)10-8-17)24-12-21-27-13-19-23(35)5-4-6-25(19)39(27)30(16-40)44-29(21)15-37-24/h4-15,30,40H,16H2,1-3H3,(H,36,41)	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD Italia S.R.L. US Patent					Assay Description Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...				US Patent US9265773 (2016) BindingDB Entry DOI: 10.7270/Q2XD10H7
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C Virus (Virus))	BDBM208162 (US9265773, 105 | US9265773, 106) Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ccc2OC(C(N)=O)n3c(cc4c(F)cccc34)-c2n1)-c1ccc(F)cc1 Show InChI InChI=1S/C33H25F2N5O6S/c1-37-32(42)28-20-13-19(24(39(2)47(3,43)44)15-27(20)45-30(28)16-7-9-17(34)10-8-16)22-11-12-26-29(38-22)25-14-18-21(35)5-4-6-23(18)40(25)33(46-26)31(36)41/h4-15,33H,1-3H3,(H2,36,41)(H,37,42)	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD Italia S.R.L. US Patent					Assay Description Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...				US Patent US9265773 (2016) BindingDB Entry DOI: 10.7270/Q2XD10H7
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C Virus (Virus))	BDBM208219 (US9265773, 164) Show SMILES CNC(=O)c1c(oc2cc(c(cc12)-c1ccc2OCn3c(cc4c(F)cccc34)-c2n1)-n1cn[nH]c1=O)-c1ccc(F)cc1 Show InChI InChI=1S/C32H20F2N6O4/c1-35-31(41)28-20-11-19(22-9-10-26-29(37-22)25-12-18-21(34)3-2-4-23(18)40(25)15-43-26)24(39-14-36-38-32(39)42)13-27(20)44-30(28)16-5-7-17(33)8-6-16/h2-14H,15H2,1H3,(H,35,41)(H,38,42)	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD Italia S.R.L. US Patent					Assay Description Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...				US Patent US9265773 (2016) BindingDB Entry DOI: 10.7270/Q2XD10H7
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C Virus (Virus))	BDBM208090 (US9265773, 33) Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1cnc2OCn3c(cc4c(cccc34)C#N)-c2n1)-c1ccc(F)cc1 Show InChI InChI=1S/C32H23FN6O5S/c1-35-31(40)28-22-11-21(25(38(2)45(3,41)42)13-27(22)44-30(28)17-7-9-19(33)10-8-17)23-15-36-32-29(37-23)26-12-20-18(14-34)5-4-6-24(20)39(26)16-43-32/h4-13,15H,16H2,1-3H3,(H,35,40)	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD Italia S.R.L. US Patent					Assay Description Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...				US Patent US9265773 (2016) BindingDB Entry DOI: 10.7270/Q2XD10H7
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C Virus (Virus))	BDBM208083 (US9265773, 26) Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ncc2OCn3c(cc4c(cccc34)C#N)-c2n1)-c1ccc(F)cc1 Show InChI InChI=1S/C32H23FN6O5S/c1-35-32(40)28-22-11-21(24(38(2)45(3,41)42)13-26(22)44-30(28)17-7-9-19(33)10-8-17)31-36-15-27-29(37-31)25-12-20-18(14-34)5-4-6-23(20)39(25)16-43-27/h4-13,15H,16H2,1-3H3,(H,35,40)	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD Italia S.R.L. US Patent					Assay Description Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...				US Patent US9265773 (2016) BindingDB Entry DOI: 10.7270/Q2XD10H7
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C Virus (Virus))	BDBM208080 (US9265773, 23) Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1cc2-c3cc4c(cccc4n3COc2cn1)C#N)-c1ccc(F)cc1 Show InChI InChI=1S/C33H24FN5O5S/c1-36-33(40)31-24-11-22(27(38(2)45(3,41)42)14-29(24)44-32(31)18-7-9-20(34)10-8-18)25-12-23-28-13-21-19(15-35)5-4-6-26(21)39(28)17-43-30(23)16-37-25/h4-14,16H,17H2,1-3H3,(H,36,40)	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD Italia S.R.L. US Patent					Assay Description Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...				US Patent US9265773 (2016) BindingDB Entry DOI: 10.7270/Q2XD10H7
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C Virus (Virus))	BDBM208061 (US9265773, 4) Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ncc2OCn3c(cc4ccccc34)-c2n1)-c1ccc(F)cc1 Show InChI InChI=1S/C31H24FN5O5S/c1-33-31(38)27-21-13-20(23(36(2)43(3,39)40)14-25(21)42-29(27)17-8-10-19(32)11-9-17)30-34-15-26-28(35-30)24-12-18-6-4-5-7-22(18)37(24)16-41-26/h4-15H,16H2,1-3H3,(H,33,38)	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD Italia S.R.L. US Patent					Assay Description Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...				US Patent US9265773 (2016) BindingDB Entry DOI: 10.7270/Q2XD10H7
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C Virus (Virus))	BDBM208180 (US9265773, 124 | US9265773, 126) Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ccc2OC(CNC(=O)[C@@H]3CCCN3C(=O)OC)n3c(cc4c(F)cccc34)-c2n1)-c1ccc(F)cc1 |r| Show InChI InChI=1S/C40H36F2N6O8S/c1-43-39(50)35-25-17-24(30(46(2)57(4,52)53)19-33(25)56-37(35)21-10-12-22(41)13-11-21)27-14-15-32-36(45-27)31-18-23-26(42)7-5-8-28(23)48(31)34(55-32)20-44-38(49)29-9-6-16-47(29)40(51)54-3/h5,7-8,10-15,17-19,29,34H,6,9,16,20H2,1-4H3,(H,43,50)(H,44,49)/t29-,34?/m0/s1	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD Italia S.R.L. US Patent					Assay Description Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...				US Patent US9265773 (2016) BindingDB Entry DOI: 10.7270/Q2XD10H7
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C Virus (Virus))	BDBM204545 (US9242998, 24) Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ccc2OC(CO)n3c(cc4c(F)cccc34)-c2n1)-c1ccc(OCC(F)(F)F)nc1 Show InChI InChI=1S/C34H27F4N5O7S/c1-39-33(45)30-20-11-19(22-8-9-26-31(41-22)25-12-18-21(35)5-4-6-23(18)43(25)29(15-44)49-26)24(42(2)51(3,46)47)13-27(20)50-32(30)17-7-10-28(40-14-17)48-16-34(36,37)38/h4-14,29,44H,15-16H2,1-3H3,(H,39,45)	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description To initiate an assay, replicon cells were plated in the presence of a dilution series of test compound in the absence of G418. Typically, the assays ...				US Patent US9242998 (2016) BindingDB Entry DOI: 10.7270/Q2SX6C2S
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C Virus (Virus))	BDBM208064 (US9265773, 7) Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ncc2OCCn3c(cc4ccccc34)-c2n1)-c1ccc(F)cc1 Show InChI InChI=1S/C32H26FN5O5S/c1-34-32(39)28-22-15-21(24(37(2)44(3,40)41)16-26(22)43-30(28)18-8-10-20(33)11-9-18)31-35-17-27-29(36-31)25-14-19-6-4-5-7-23(19)38(25)12-13-42-27/h4-11,14-17H,12-13H2,1-3H3,(H,34,39)	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD Italia S.R.L. US Patent					Assay Description Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...				US Patent US9265773 (2016) BindingDB Entry DOI: 10.7270/Q2XD10H7
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C Virus (Virus))	BDBM208181 (US9265773, 125 | US9265773, 127) Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ccc2OC(CNC(=O)[C@@H](NC(=O)OC)C(C)C)n3c(cc4c(F)cccc34)-c2n1)-c1ccc(F)cc1 |r| Show InChI InChI=1S/C40H38F2N6O8S/c1-20(2)35(46-40(51)54-5)39(50)44-19-33-48-28-9-7-8-26(42)23(28)17-30(48)36-31(55-33)15-14-27(45-36)24-16-25-32(18-29(24)47(4)57(6,52)53)56-37(34(25)38(49)43-3)21-10-12-22(41)13-11-21/h7-18,20,33,35H,19H2,1-6H3,(H,43,49)(H,44,50)(H,46,51)/t33?,35-/m0/s1	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD Italia S.R.L. US Patent					Assay Description Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...				US Patent US9265773 (2016) BindingDB Entry DOI: 10.7270/Q2XD10H7
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C Virus (Virus))	BDBM208248 (US9265773, 193) Show SMILES CNC(=O)c1c(oc2cc(N(CCF)S(C)(=O)=O)c(cc12)-c1ncc2OCn3c(cc4c(F)cccc34)-c2n1)-c1ccc(F)cc1 Show InChI InChI=1S/C32H24F3N5O5S/c1-36-32(41)28-21-12-20(31-37-15-27-29(38-31)25-13-19-22(35)4-3-5-23(19)39(25)16-44-27)24(40(11-10-33)46(2,42)43)14-26(21)45-30(28)17-6-8-18(34)9-7-17/h3-9,12-15H,10-11,16H2,1-2H3,(H,36,41)	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD Italia S.R.L. US Patent					Assay Description Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...				US Patent US9265773 (2016) BindingDB Entry DOI: 10.7270/Q2XD10H7
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C Virus (Virus))	BDBM208106 (US9265773, 49) Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ccc2OCn3c(cc4cccnc34)-c2c1)-c1ccc(F)cc1 Show InChI InChI=1S/C32H25FN4O5S/c1-34-32(38)29-24-15-22(19-8-11-27-23(13-19)26-14-20-5-4-12-35-31(20)37(26)17-41-27)25(36(2)43(3,39)40)16-28(24)42-30(29)18-6-9-21(33)10-7-18/h4-16H,17H2,1-3H3,(H,34,38)	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD Italia S.R.L. US Patent					Assay Description Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...				US Patent US9265773 (2016) BindingDB Entry DOI: 10.7270/Q2XD10H7
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C Virus (Virus))	BDBM208069 (US9265773, 12) Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ccc2OCn3c(cc4c(cccc34)C#N)-c2n1)-c1ccc(F)cc1 Show InChI InChI=1S/C33H24FN5O5S/c1-36-33(40)30-23-13-22(26(38(2)45(3,41)42)15-29(23)44-32(30)18-7-9-20(34)10-8-18)24-11-12-28-31(37-24)27-14-21-19(16-35)5-4-6-25(21)39(27)17-43-28/h4-15H,17H2,1-3H3,(H,36,40)	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD Italia S.R.L. US Patent					Assay Description Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...				US Patent US9265773 (2016) BindingDB Entry DOI: 10.7270/Q2XD10H7
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C Virus (Virus))	BDBM204721 (US9243002, 58 | US9243002, 59) Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ccc2CC(CS(C)(=O)=O)n3c(cc4c(F)cccc34)-c2n1)-c1ccc(F)cc1F Show InChI InChI=1S/C35H29F3N4O6S2/c1-39-35(43)32-24-14-23(29(41(2)50(4,46)47)16-31(24)48-34(32)21-10-9-19(36)13-26(21)38)27-11-8-18-12-20(17-49(3,44)45)42-28-7-5-6-25(37)22(28)15-30(42)33(18)40-27/h5-11,13-16,20H,12,17H2,1-4H3,(H,39,43)	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.71	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description To initiate an assay, replicon cells were plated in the presence of a dilution series of test compound in the absence of G418. Typically, the assays ...				US Patent US9243002 (2016) BindingDB Entry DOI: 10.7270/Q2P55MBC
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C Virus (Virus))	BDBM204534 (US9242998, 12) Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ccc2OCn3c(cc4c(F)cccc34)-c2n1)-c1ccc(OCC(F)(F)F)nc1 Show InChI InChI=1S/C33H25F4N5O6S/c1-38-32(43)29-20-11-19(22-8-9-26-30(40-22)25-12-18-21(34)5-4-6-23(18)42(25)16-47-26)24(41(2)49(3,44)45)13-27(20)48-31(29)17-7-10-28(39-14-17)46-15-33(35,36)37/h4-14H,15-16H2,1-3H3,(H,38,43)	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description To initiate an assay, replicon cells were plated in the presence of a dilution series of test compound in the absence of G418. Typically, the assays ...				US Patent US9242998 (2016) BindingDB Entry DOI: 10.7270/Q2SX6C2S
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C Virus (Virus))	BDBM208104 (US9265773, 47) Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ccc2OCn3c(cc4c(nccc34)C#N)-c2n1)-c1ccc(F)cc1 Show InChI InChI=1S/C32H23FN6O5S/c1-35-32(40)29-21-12-19(25(38(2)45(3,41)42)14-28(21)44-31(29)17-4-6-18(33)7-5-17)22-8-9-27-30(37-22)26-13-20-23(15-34)36-11-10-24(20)39(26)16-43-27/h4-14H,16H2,1-3H3,(H,35,40)	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD Italia S.R.L. US Patent					Assay Description Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...				US Patent US9265773 (2016) BindingDB Entry DOI: 10.7270/Q2XD10H7
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C Virus (Virus))	BDBM208096 (US9265773, 39) Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ncc2OCCCn3c(cc4ccccc34)-c2n1)-c1ccc(F)cc1 Show InChI InChI=1S/C33H28FN5O5S/c1-35-33(40)29-23-16-22(25(38(2)45(3,41)42)17-27(23)44-31(29)19-9-11-21(34)12-10-19)32-36-18-28-30(37-32)26-15-20-7-4-5-8-24(20)39(26)13-6-14-43-28/h4-5,7-12,15-18H,6,13-14H2,1-3H3,(H,35,40)	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD Italia S.R.L. US Patent					Assay Description Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...				US Patent US9265773 (2016) BindingDB Entry DOI: 10.7270/Q2XD10H7
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C Virus (Virus))	BDBM208082 (US9265773, 25) Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1cnc2OCn3c(cc4c(F)cccc34)-c2n1)-c1ccc(F)cc1 Show InChI InChI=1S/C31H23F2N5O5S/c1-34-30(39)27-20-11-19(24(37(2)44(3,40)41)13-26(20)43-29(27)16-7-9-17(32)10-8-16)22-14-35-31-28(36-22)25-12-18-21(33)5-4-6-23(18)38(25)15-42-31/h4-14H,15H2,1-3H3,(H,34,39)	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD Italia S.R.L. US Patent					Assay Description Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...				US Patent US9265773 (2016) BindingDB Entry DOI: 10.7270/Q2XD10H7
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C Virus (Virus))	BDBM208068 (US9265773, 11) Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1cc2-c3cc4ccccc4n3COc2cn1)-c1ccc(F)cc1 Show InChI InChI=1S/C32H25FN4O5S/c1-34-32(38)30-23-13-21(24-14-22-27-12-19-6-4-5-7-25(19)37(27)17-41-29(22)16-35-24)26(36(2)43(3,39)40)15-28(23)42-31(30)18-8-10-20(33)11-9-18/h4-16H,17H2,1-3H3,(H,34,38)	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD Italia S.R.L. US Patent					Assay Description Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...				US Patent US9265773 (2016) BindingDB Entry DOI: 10.7270/Q2XD10H7
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C Virus (Virus))	BDBM204715 (US9243002, 55) Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ccc2C(CO)n3c(cc4c(F)cccc34)-c2n1)-c1ccc(F)cc1 Show InChI InChI=1S/C33H26F2N4O5S/c1-36-33(41)30-22-13-21(26(38(2)45(3,42)43)15-29(22)44-32(30)17-7-9-18(34)10-8-17)24-12-11-19-28(16-40)39-25-6-4-5-23(35)20(25)14-27(39)31(19)37-24/h4-15,28,40H,16H2,1-3H3,(H,36,41)	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.81	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description To initiate an assay, replicon cells were plated in the presence of a dilution series of test compound in the absence of G418. Typically, the assays ...				US Patent US9243002 (2016) BindingDB Entry DOI: 10.7270/Q2P55MBC
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C Virus (Virus))	BDBM204669 (US9243002, 44) Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1cnc2CCn3c(cc4c(F)cccc34)-c2n1)-c1ccc(F)cc1 Show InChI InChI=1S/C32H25F2N5O4S/c1-35-32(40)29-21-13-20(26(38(2)44(3,41)42)15-28(21)43-31(29)17-7-9-18(33)10-8-17)24-16-36-23-11-12-39-25-6-4-5-22(34)19(25)14-27(39)30(23)37-24/h4-10,13-16H,11-12H2,1-3H3,(H,35,40)	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.87	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description To initiate an assay, replicon cells were plated in the presence of a dilution series of test compound in the absence of G418. Typically, the assays ...				US Patent US9243002 (2016) BindingDB Entry DOI: 10.7270/Q2P55MBC
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C Virus (Virus))	BDBM208194 (US9265773, 139) Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ccc2OCn3c(nc4c(F)cccc34)-c2n1)-c1ccc(F)cc1 Show InChI InChI=1S/C31H23F2N5O5S/c1-34-31(39)26-19-13-18(23(37(2)44(3,40)41)14-25(19)43-29(26)16-7-9-17(32)10-8-16)21-11-12-24-28(35-21)30-36-27-20(33)5-4-6-22(27)38(30)15-42-24/h4-14H,15H2,1-3H3,(H,34,39)	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD Italia S.R.L. US Patent					Assay Description Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...				US Patent US9265773 (2016) BindingDB Entry DOI: 10.7270/Q2XD10H7
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C Virus (Virus))	BDBM208079 (US9265773, 22) Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ccc2OCn3c(cc4ccc(cc34)C#N)-c2n1)-c1ccc(F)cc1 Show InChI InChI=1S/C33H24FN5O5S/c1-36-33(40)30-23-14-22(26(38(2)45(3,41)42)15-29(23)44-32(30)19-6-8-21(34)9-7-19)24-10-11-28-31(37-24)27-13-20-5-4-18(16-35)12-25(20)39(27)17-43-28/h4-15H,17H2,1-3H3,(H,36,40)	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD Italia S.R.L. US Patent					Assay Description Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...				US Patent US9265773 (2016) BindingDB Entry DOI: 10.7270/Q2XD10H7
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C Virus (Virus))	BDBM208199 (US9265773, 144 | US9265773, 145) Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1cnc2OCc3c(nc4ccccn34)-c2c1)-c1ccc(F)cc1 Show InChI InChI=1S/C31H24FN5O5S/c1-33-30(38)27-21-13-20(18-12-22-28-24(16-41-31(22)34-15-18)37-11-5-4-6-26(37)35-28)23(36(2)43(3,39)40)14-25(21)42-29(27)17-7-9-19(32)10-8-17/h4-15H,16H2,1-3H3,(H,33,38)	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD Italia S.R.L. US Patent					Assay Description Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...				US Patent US9265773 (2016) BindingDB Entry DOI: 10.7270/Q2XD10H7
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C Virus (Virus))	BDBM208066 (US9265773, 9) Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ncc2OC(C)n3c(cc4ccccc34)-c2n1)-c1ccc(F)cc1 Show InChI InChI=1S/C32H26FN5O5S/c1-17-38-23-8-6-5-7-19(23)13-25(38)29-27(42-17)16-35-31(36-29)21-14-22-26(15-24(21)37(3)44(4,40)41)43-30(28(22)32(39)34-2)18-9-11-20(33)12-10-18/h5-17H,1-4H3,(H,34,39)	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD Italia S.R.L. US Patent					Assay Description Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...				US Patent US9265773 (2016) BindingDB Entry DOI: 10.7270/Q2XD10H7
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C Virus (Virus))	BDBM204716 (US9243002, 56 | US9243002, 57) Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ccc2CC(CS(C)(=O)=O)n3c(cc4c(F)cccc34)-c2n1)-c1ccc(F)cc1 Show InChI InChI=1S/C35H30F2N4O6S2/c1-38-35(42)32-25-15-24(29(40(2)49(4,45)46)17-31(25)47-34(32)19-8-11-21(36)12-9-19)27-13-10-20-14-22(18-48(3,43)44)41-28-7-5-6-26(37)23(28)16-30(41)33(20)39-27/h5-13,15-17,22H,14,18H2,1-4H3,(H,38,42)	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.00	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description To initiate an assay, replicon cells were plated in the presence of a dilution series of test compound in the absence of G418. Typically, the assays ...				US Patent US9243002 (2016) BindingDB Entry DOI: 10.7270/Q2P55MBC
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C Virus (Virus))	BDBM208062 (US9265773, 5) Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ncc2OCn3c(cc4c(F)cccc34)-c2n1)-c1ccc(F)cc1 Show InChI InChI=1S/C31H23F2N5O5S/c1-34-31(39)27-20-11-19(23(37(2)44(3,40)41)13-25(20)43-29(27)16-7-9-17(32)10-8-16)30-35-14-26-28(36-30)24-12-18-21(33)5-4-6-22(18)38(24)15-42-26/h4-14H,15H2,1-3H3,(H,34,39)	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD Italia S.R.L. US Patent					Assay Description Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...				US Patent US9265773 (2016) BindingDB Entry DOI: 10.7270/Q2XD10H7
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C Virus (Virus))	BDBM208177 (US9265773, 120) Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ccc2OC(CNCCOC)n3c(cc4c(F)cccc34)-c2n1)-c1ccc(F)cc1 Show InChI InChI=1S/C36H33F2N5O6S/c1-39-36(44)33-24-16-23(28(42(2)50(4,45)46)18-31(24)49-35(33)20-8-10-21(37)11-9-20)26-12-13-30-34(41-26)29-17-22-25(38)6-5-7-27(22)43(29)32(48-30)19-40-14-15-47-3/h5-13,16-18,32,40H,14-15,19H2,1-4H3,(H,39,44)	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD Italia S.R.L. US Patent					Assay Description Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...				US Patent US9265773 (2016) BindingDB Entry DOI: 10.7270/Q2XD10H7
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C Virus (Virus))	BDBM208166 (US9265773, 109 | US9265773, 110) Show SMILES CNC(=O)C1Oc2ccc(nc2-c2cc3c(F)cccc3n12)-c1cc2c(C(=O)NC)c(oc2cc1N(C)S(C)(=O)=O)-c1ccc(F)cc1 Show InChI InChI=1S/C34H27F2N5O6S/c1-37-32(42)29-21-14-20(25(40(3)48(4,44)45)16-28(21)46-31(29)17-8-10-18(35)11-9-17)23-12-13-27-30(39-23)26-15-19-22(36)6-5-7-24(19)41(26)34(47-27)33(43)38-2/h5-16,34H,1-4H3,(H,37,42)(H,38,43)	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD Italia S.R.L. US Patent					Assay Description Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...				US Patent US9265773 (2016) BindingDB Entry DOI: 10.7270/Q2XD10H7
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C Virus (Virus))	BDBM208262 (US9265773, 207) Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ccc2OCn3c(c(C(O)C(O)=O)c4c(F)cccc34)-c2n1)-c1ccc(F)cc1 Show InChI InChI=1S/C34H26F2N4O8S/c1-37-33(42)26-19-13-18(23(39(2)49(3,45)46)14-25(19)48-32(26)16-7-9-17(35)10-8-16)21-11-12-24-29(38-21)30-28(31(41)34(43)44)27-20(36)5-4-6-22(27)40(30)15-47-24/h4-14,31,41H,15H2,1-3H3,(H,37,42)(H,43,44)	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD Italia S.R.L. US Patent					Assay Description Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...				US Patent US9265773 (2016) BindingDB Entry DOI: 10.7270/Q2XD10H7
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C Virus (Virus))	BDBM208228 (US9265773, 173) Show SMILES CNC(=O)c1c(oc2cc(N3CCOC3=O)c(cc12)-c1ncc2OCn3c(cc4c(F)cccc34)-c2n1)-c1ccc(F)cc1 Show InChI InChI=1S/C32H21F2N5O5/c1-35-31(40)27-20-11-19(23(38-9-10-42-32(38)41)13-25(20)44-29(27)16-5-7-17(33)8-6-16)30-36-14-26-28(37-30)24-12-18-21(34)3-2-4-22(18)39(24)15-43-26/h2-8,11-14H,9-10,15H2,1H3,(H,35,40)	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD Italia S.R.L. US Patent					Assay Description Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...				US Patent US9265773 (2016) BindingDB Entry DOI: 10.7270/Q2XD10H7
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C Virus (Virus))	BDBM208227 (US9265773, 172) Show SMILES CNC(=O)c1c(oc2cc(N3CCOC3=O)c(cc12)-c1ccc2OCn3c(cc4c(F)cccc34)-c2n1)-c1ccc(F)cc1 Show InChI InChI=1S/C33H22F2N4O5/c1-36-32(40)29-21-13-20(23-9-10-27-30(37-23)26-14-19-22(35)3-2-4-24(19)39(26)16-43-27)25(38-11-12-42-33(38)41)15-28(21)44-31(29)17-5-7-18(34)8-6-17/h2-10,13-15H,11-12,16H2,1H3,(H,36,40)	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD Italia S.R.L. US Patent					Assay Description Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...				US Patent US9265773 (2016) BindingDB Entry DOI: 10.7270/Q2XD10H7
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C Virus (Virus))	BDBM208065 (US9265773, 8) Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ncc2OCCn3c(cc4c(F)cccc34)-c2n1)-c1ccc(F)cc1 Show InChI InChI=1S/C32H25F2N5O5S/c1-35-32(40)28-21-13-20(24(38(2)45(3,41)42)15-26(21)44-30(28)17-7-9-18(33)10-8-17)31-36-16-27-29(37-31)25-14-19-22(34)5-4-6-23(19)39(25)11-12-43-27/h4-10,13-16H,11-12H2,1-3H3,(H,35,40)	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD Italia S.R.L. US Patent					Assay Description Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...				US Patent US9265773 (2016) BindingDB Entry DOI: 10.7270/Q2XD10H7
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C Virus (Virus))	BDBM208103 (US9265773, 46) Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ccc2OCn3c(cc4c(F)cncc34)-c2n1)-c1ccc(F)cc1 Show InChI InChI=1S/C31H23F2N5O5S/c1-34-31(39)28-20-10-19(23(37(2)44(3,40)41)12-27(20)43-30(28)16-4-6-17(32)7-5-16)22-8-9-26-29(36-22)24-11-18-21(33)13-35-14-25(18)38(24)15-42-26/h4-14H,15H2,1-3H3,(H,34,39)	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD Italia S.R.L. US Patent					Assay Description Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...				US Patent US9265773 (2016) BindingDB Entry DOI: 10.7270/Q2XD10H7
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C Virus (Virus))	BDBM208185 (US9265773, 129 | US9265773, 130) Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ccc2OC(CNC(C)=O)n3c(cc4c(F)cccc34)-c2n1)-c1ccc(F)cc1 Show InChI InChI=1S/C35H29F2N5O6S/c1-18(43)39-17-31-42-26-7-5-6-24(37)21(26)15-28(42)33-29(47-31)13-12-25(40-33)22-14-23-30(16-27(22)41(3)49(4,45)46)48-34(32(23)35(44)38-2)19-8-10-20(36)11-9-19/h5-16,31H,17H2,1-4H3,(H,38,44)(H,39,43)	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD Italia S.R.L. US Patent					Assay Description Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...				US Patent US9265773 (2016) BindingDB Entry DOI: 10.7270/Q2XD10H7
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C Virus (Virus))	BDBM208087 (US9265773, 30) Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ncc2OCn3c(cc4c(F)c(F)ccc34)-c2n1)-c1ccc(F)cc1 Show InChI InChI=1S/C31H22F3N5O5S/c1-35-31(40)26-19-10-18(22(38(2)45(3,41)42)12-24(19)44-29(26)15-4-6-16(32)7-5-15)30-36-13-25-28(37-30)23-11-17-21(39(23)14-43-25)9-8-20(33)27(17)34/h4-13H,14H2,1-3H3,(H,35,40)	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD Italia S.R.L. US Patent					Assay Description Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...				US Patent US9265773 (2016) BindingDB Entry DOI: 10.7270/Q2XD10H7
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C Virus (Virus))	BDBM208070 (US9265773, 13) Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ccc2OCn3c(cc4cc(ccc34)C#N)-c2n1)-c1ccc(F)cc1 Show InChI InChI=1S/C33H24FN5O5S/c1-36-33(40)30-23-14-22(26(38(2)45(3,41)42)15-29(23)44-32(30)19-5-7-21(34)8-6-19)24-9-11-28-31(37-24)27-13-20-12-18(16-35)4-10-25(20)39(27)17-43-28/h4-15H,17H2,1-3H3,(H,36,40)	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD Italia S.R.L. US Patent					Assay Description Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...				US Patent US9265773 (2016) BindingDB Entry DOI: 10.7270/Q2XD10H7
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C Virus (Virus))	BDBM208246 (US9265773, 191) Show SMILES CNC(=O)c1c(oc2cc(N(CCF)S(C)(=O)=O)c(cc12)-c1ccc2OCn3c(cc4c(cccc34)C#N)-c2n1)-c1ccc(F)cc1 Show InChI InChI=1S/C34H25F2N5O5S/c1-38-34(42)31-24-14-23(25-10-11-29-32(39-25)28-15-22-20(17-37)4-3-5-26(22)40(28)18-45-29)27(41(13-12-35)47(2,43)44)16-30(24)46-33(31)19-6-8-21(36)9-7-19/h3-11,14-16H,12-13,18H2,1-2H3,(H,38,42)	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD Italia S.R.L. US Patent					Assay Description Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...				US Patent US9265773 (2016) BindingDB Entry DOI: 10.7270/Q2XD10H7
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C Virus (Virus))	BDBM208204 (US9265773, 149) Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ncc2OCn3c(cc4c(F)cccc34)-c2n1)-c1ccc(F)cc1F Show InChI InChI=1S/C31H22F3N5O5S/c1-35-31(40)27-19-10-18(23(38(2)45(3,41)42)12-25(19)44-29(27)16-8-7-15(32)9-21(16)34)30-36-13-26-28(37-30)24-11-17-20(33)5-4-6-22(17)39(24)14-43-26/h4-13H,14H2,1-3H3,(H,35,40)	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD Italia S.R.L. US Patent					Assay Description Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...				US Patent US9265773 (2016) BindingDB Entry DOI: 10.7270/Q2XD10H7
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C Virus (Virus))	BDBM208209 (US9265773, 154) Show SMILES CN(c1cc2oc(c(C(N)=O)c2cc1-c1ccc2OCn3c(cc4c(F)cccc34)-c2n1)-c1ccc(F)cc1)S(C)(=O)=O Show InChI InChI=1S/C31H22F2N4O5S/c1-36(43(2,39)40)24-14-27-20(28(31(34)38)30(42-27)16-6-8-17(32)9-7-16)12-19(24)22-10-11-26-29(35-22)25-13-18-21(33)4-3-5-23(18)37(25)15-41-26/h3-14H,15H2,1-2H3,(H2,34,38)	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD Italia S.R.L. US Patent					Assay Description Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...				US Patent US9265773 (2016) BindingDB Entry DOI: 10.7270/Q2XD10H7
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C Virus (Virus))	BDBM208097 (US9265773, 40) Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ncc2OCCCn3c(cc4c(F)cccc34)-c2n1)-c1ccc(F)cc1 Show InChI InChI=1S/C33H27F2N5O5S/c1-36-33(41)29-22-14-21(25(39(2)46(3,42)43)16-27(22)45-31(29)18-8-10-19(34)11-9-18)32-37-17-28-30(38-32)26-15-20-23(35)6-4-7-24(20)40(26)12-5-13-44-28/h4,6-11,14-17H,5,12-13H2,1-3H3,(H,36,41)	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD Italia S.R.L. US Patent					Assay Description Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...				US Patent US9265773 (2016) BindingDB Entry DOI: 10.7270/Q2XD10H7
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C Virus (Virus))	BDBM208218 (US9265773, 163) Show SMILES CNC(=O)c1c(oc2cc(N)c(cc12)-c1ccc2OCn3c(cc4c(F)cccc34)-c2n1)-c1ccc(F)cc1 Show InChI InChI=1S/C30H20F2N4O3/c1-34-30(37)27-19-11-18(21(33)13-26(19)39-29(27)15-5-7-16(31)8-6-15)22-9-10-25-28(35-22)24-12-17-20(32)3-2-4-23(17)36(24)14-38-25/h2-13H,14,33H2,1H3,(H,34,37)	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD Italia S.R.L. US Patent					Assay Description Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...				US Patent US9265773 (2016) BindingDB Entry DOI: 10.7270/Q2XD10H7
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C Virus (Virus))	BDBM204712 (US9243002, 52 | US9243002, 53 | US9243002, 54) Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ccc2CC(CO)n3c(cc4c(F)cccc34)-c2n1)-c1ccc(F)cc1 Show InChI InChI=1S/C34H28F2N4O5S/c1-37-34(42)31-24-14-23(28(39(2)46(3,43)44)16-30(24)45-33(31)18-7-10-20(35)11-8-18)26-12-9-19-13-21(17-41)40-27-6-4-5-25(36)22(27)15-29(40)32(19)38-26/h4-12,14-16,21,41H,13,17H2,1-3H3,(H,37,42)	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.25	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description To initiate an assay, replicon cells were plated in the presence of a dilution series of test compound in the absence of G418. Typically, the assays ...				US Patent US9243002 (2016) BindingDB Entry DOI: 10.7270/Q2P55MBC
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C Virus (Virus))	BDBM204586 (US9243002, 5) Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ccc2CCn3c(cc4c(F)cccc34)-c2n1)-c1ccc(OC2CC2)nc1 Show InChI InChI=1S/C35H30FN5O5S/c1-37-35(42)32-24-15-23(26-11-7-19-13-14-41-27-6-4-5-25(36)22(27)16-29(41)33(19)39-26)28(40(2)47(3,43)44)17-30(24)46-34(32)20-8-12-31(38-18-20)45-21-9-10-21/h4-8,11-12,15-18,21H,9-10,13-14H2,1-3H3,(H,37,42)	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description To initiate an assay, replicon cells were plated in the presence of a dilution series of test compound in the absence of G418. Typically, the assays ...				US Patent US9243002 (2016) BindingDB Entry DOI: 10.7270/Q2P55MBC
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C Virus (Virus))	BDBM208073 (US9265773, 16) Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1cc2-c3cc4c(F)cccc4n3COc2cn1)-c1ccc(F)cc1 Show InChI InChI=1S/C32H24F2N4O5S/c1-35-32(39)30-22-11-20(26(37(2)44(3,40)41)14-28(22)43-31(30)17-7-9-18(33)10-8-17)24-12-21-27-13-19-23(34)5-4-6-25(19)38(27)16-42-29(21)15-36-24/h4-15H,16H2,1-3H3,(H,35,39)	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD Italia S.R.L. US Patent					Assay Description Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...				US Patent US9265773 (2016) BindingDB Entry DOI: 10.7270/Q2XD10H7
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C Virus (Virus))	BDBM208249 (US9265773, 194) Show SMILES CNC(=O)c1c(oc2cc(N(CCCF)S(C)(=O)=O)c(cc12)-c1ccc2OCn3c(cc4c(cccc34)C#N)-c2n1)-c1ccc(F)cc1 Show InChI InChI=1S/C35H27F2N5O5S/c1-39-35(43)32-25-15-24(26-11-12-30-33(40-26)29-16-23-21(18-38)5-3-6-27(23)41(29)19-46-30)28(42(14-4-13-36)48(2,44)45)17-31(25)47-34(32)20-7-9-22(37)10-8-20/h3,5-12,15-17H,4,13-14,19H2,1-2H3,(H,39,43)	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD Italia S.R.L. US Patent					Assay Description Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...				US Patent US9265773 (2016) BindingDB Entry DOI: 10.7270/Q2XD10H7
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C Virus (Virus))	BDBM208063 (US9265773, 6) Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ncc2OCn3c(cc4cc(F)ccc34)-c2n1)-c1ccc(F)cc1 Show InChI InChI=1S/C31H23F2N5O5S/c1-34-31(39)27-21-12-20(23(37(2)44(3,40)41)13-25(21)43-29(27)16-4-6-18(32)7-5-16)30-35-14-26-28(36-30)24-11-17-10-19(33)8-9-22(17)38(24)15-42-26/h4-14H,15H2,1-3H3,(H,34,39)	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; MSD Italia S.R.L. US Patent					Assay Description Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...				US Patent US9265773 (2016) BindingDB Entry DOI: 10.7270/Q2XD10H7
					More data for this Ligand-Target Pair

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