Compile Data Set for Download or QSAR

Found 150 hits of ic50 data for polymerid = 7498   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Alpha-synuclein (Homo sapiens (Human))	BDBM50614057 (CHEMBL5286894) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	UniChem		n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Alpha-synuclein (Homo sapiens (Human))	BDBM50389294 (CHEMBL2063787) Show SMILES COc1ccc2Nc3ccc(cc3Sc2c1)[N+]([O-])=O Show InChI InChI=1S/C13H10N2O3S/c1-18-9-3-5-11-13(7-9)19-12-6-8(15(16)17)2-4-10(12)14-11/h2-7,14H,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	134	n/a	n/a	n/a	n/a	n/a	n/a
Washington University School of Medicine Curated by ChEMBL					Assay Description Binding affinity to human alpha-synuclein expressed in Escherichia coli BL21 (DE3) cells after 1 hr by thioflavin T fluorescence assay				Bioorg Med Chem 20: 4625-34 (2012) Article DOI: 10.1016/j.bmc.2012.06.023 BindingDB Entry DOI: 10.7270/Q25B03J1
					More data for this Ligand-Target Pair
Alpha-synuclein (Homo sapiens (Human))	BDBM50092056 ((2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclo...) Show SMILES C\C(=C/CO)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C |c:12| Show InChI InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of alpha-synuclein fibril formation (unknown origin) incubated for 24 hrs to 7 days by thioflavin S based fluorescence assay				Citation and Details Article DOI: 10.1016/j.ejmech.2019.01.045 BindingDB Entry DOI: 10.7270/Q2H998V9
					More data for this Ligand-Target Pair
Alpha-synuclein (Homo sapiens (Human))	BDBM50553255 (All-Trans-Retinal | CHEBI:17898 | Retinal) Show SMILES C\C(\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C)=C/C=O |c:9| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of alpha-synuclein fibril formation (unknown origin) incubated for 24 hrs to 7 days by thioflavin S based fluorescence assay				Citation and Details Article DOI: 10.1016/j.ejmech.2019.01.045 BindingDB Entry DOI: 10.7270/Q2H998V9
					More data for this Ligand-Target Pair
Alpha-synuclein (Homo sapiens (Human))	BDBM50389304 (CHEMBL2063797) Show SMILES [O-][N+](=O)c1ccc2Nc3ccc(OCCF)cc3Sc2c1 Show InChI InChI=1S/C14H11FN2O3S/c15-5-6-20-10-2-4-12-14(8-10)21-13-7-9(17(18)19)1-3-11(13)16-12/h1-4,7-8,16H,5-6H2	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	204	n/a	n/a	n/a	n/a	n/a	n/a
Washington University School of Medicine Curated by ChEMBL					Assay Description Binding affinity to human alpha-synuclein expressed in Escherichia coli BL21 (DE3) cells after 1 hr by thioflavin T fluorescence assay				Bioorg Med Chem 20: 4625-34 (2012) Article DOI: 10.1016/j.bmc.2012.06.023 BindingDB Entry DOI: 10.7270/Q25B03J1
					More data for this Ligand-Target Pair
Alpha-synuclein (Homo sapiens (Human))	BDBM32020 (4-[4-(3,4-dihydroxyphenyl)-2,3-dimethyl-butyl]pyro...) Show SMILES CC(Cc1ccc(O)c(O)c1)C(C)Cc1ccc(O)c(O)c1 Show InChI InChI=1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of alpha-synuclein aggregation (unknown origin) incubated for 8 days by thioflavin S based fluorescence assay				Citation and Details Article DOI: 10.1016/j.ejmech.2019.01.045 BindingDB Entry DOI: 10.7270/Q2H998V9
					More data for this Ligand-Target Pair
Alpha-synuclein (Homo sapiens (Human))	BDBM50133496 ((2R)-3-(3,4-dihydroxyphenyl)-2-[(2E)-3-(3,4-dihydr...) Show SMILES OC(=O)[C@@H](Cc1ccc(O)c(O)c1)OC(=O)\C=C\c1ccc(O)c(O)c1 |r| Show InChI InChI=1S/C18H16O8/c19-12-4-1-10(7-14(12)21)3-6-17(23)26-16(18(24)25)9-11-2-5-13(20)15(22)8-11/h1-8,16,19-22H,9H2,(H,24,25)/b6-3+/t16-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of alpha-synuclein fibril formation (unknown origin) incubated for 24 hrs to 7 days by thioflavin S based fluorescence assay				Citation and Details Article DOI: 10.1016/j.ejmech.2019.01.045 BindingDB Entry DOI: 10.7270/Q2H998V9
					More data for this Ligand-Target Pair
Alpha-synuclein (Homo sapiens (Human))	BDBM50140172 (CHEBI:3962 | CHEMBL140 | Curcumin | US9409845, Tab...) Show SMILES COc1cc(\C=C\C(=O)CC(=O)\C=C\c2ccc(O)c(OC)c2)ccc1O Show InChI InChI=1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	220	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of alpha-synuclein fibril formation (unknown origin) incubated for 24 hrs to 7 days by thioflavin S based fluorescence assay				Citation and Details Article DOI: 10.1016/j.ejmech.2019.01.045 BindingDB Entry DOI: 10.7270/Q2H998V9
					More data for this Ligand-Target Pair
Alpha-synuclein (Homo sapiens (Human))	BDBM15236 (3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chr...) Show SMILES Oc1cc(O)c2c(c1)oc(-c1cc(O)c(O)c(O)c1)c(O)c2=O Show InChI InChI=1S/C15H10O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,16-20,22H	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	220	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of alpha-synuclein fibril formation (unknown origin) incubated for 24 hrs to 7 days by thioflavin S based fluorescence assay				Citation and Details Article DOI: 10.1016/j.ejmech.2019.01.045 BindingDB Entry DOI: 10.7270/Q2H998V9
					More data for this Ligand-Target Pair
Alpha-synuclein (Homo sapiens (Human))	BDBM32020 (4-[4-(3,4-dihydroxyphenyl)-2,3-dimethyl-butyl]pyro...) Show SMILES CC(Cc1ccc(O)c(O)c1)C(C)Cc1ccc(O)c(O)c1 Show InChI InChI=1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	220	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of alpha-synuclein fibril formation (unknown origin) incubated for 24 hrs to 7 days by thioflavin S based fluorescence assay				Citation and Details Article DOI: 10.1016/j.ejmech.2019.01.045 BindingDB Entry DOI: 10.7270/Q2H998V9
					More data for this Ligand-Target Pair
Alpha-synuclein (Homo sapiens (Human))	BDBM50389305 (CHEMBL2063798) Show SMILES [O-][N+](=O)c1ccc2Nc3ccc(OC\C=C\I)cc3Sc2c1 Show InChI InChI=1S/C15H11IN2O3S/c16-6-1-7-21-11-3-5-13-15(9-11)22-14-8-10(18(19)20)2-4-12(14)17-13/h1-6,8-9,17H,7H2/b6-1+	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	241	n/a	n/a	n/a	n/a	n/a	n/a
Washington University School of Medicine Curated by ChEMBL					Assay Description Binding affinity to human alpha-synuclein expressed in Escherichia coli BL21 (DE3) cells after 1 hr by thioflavin T fluorescence assay				Bioorg Med Chem 20: 4625-34 (2012) Article DOI: 10.1016/j.bmc.2012.06.023 BindingDB Entry DOI: 10.7270/Q25B03J1
					More data for this Ligand-Target Pair
Alpha-synuclein (Homo sapiens (Human))	BDBM50553254 (CHEMBL4787961) Show SMILES C\C(\C=C\C=C(/C)\C=C\C1=C(C)CCCC1)=C/C=C/C=C(\C)/C=C/C=C(\C)/C=C/C1=C(C)CCCC1(C)C |c:9,30| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of alpha-synuclein fibril formation (unknown origin) incubated for 24 hrs to 7 days by thioflavin S based fluorescence assay				Citation and Details Article DOI: 10.1016/j.ejmech.2019.01.045 BindingDB Entry DOI: 10.7270/Q2H998V9
					More data for this Ligand-Target Pair
Alpha-synuclein (Homo sapiens (Human))	BDBM510815 (N-(1-(1H-Indol-3-yl)hexan-2- yl)-2-(piperazin-1-yl...) Show SMILES CCCCC(Cc1c[nH]c2ccccc12)NC(=O)c1cnc(s1)N1CCNCC1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	270	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The fluorescence polarization assay tests the ability of compounds to inhibit the self-aggregation of α-synuclein peptide fragments. Peptides we...				Citation and Details BindingDB Entry DOI: 10.7270/Q2NV9NDS
					More data for this Ligand-Target Pair
Alpha-synuclein (Homo sapiens (Human))	BDBM15579 (CHEMBL972 | DEPRENYL | L-Deprenyl | N-methyl-N-[(2...) Show SMILES C[C@H](Cc1ccccc1)N(C)CC#C |r| Show InChI InChI=1S/C13H17N/c1-4-10-14(3)12(2)11-13-8-6-5-7-9-13/h1,5-9,12H,10-11H2,2-3H3/t12-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	270	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of alpha-synuclein fibril formation (unknown origin) incubated for 6 days by thioflavin S based fluorescence assay				Citation and Details Article DOI: 10.1016/j.ejmech.2019.01.045 BindingDB Entry DOI: 10.7270/Q2H998V9
					More data for this Ligand-Target Pair
Alpha-synuclein (Homo sapiens (Human))	BDBM50389295 (CHEMBL2063788) Show SMILES [O-][N+](=O)c1ccc2Nc3ccc(Br)cc3Sc2c1 Show InChI InChI=1S/C12H7BrN2O2S/c13-7-1-3-9-11(5-7)18-12-6-8(15(16)17)2-4-10(12)14-9/h1-6,14H	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	314	n/a	n/a	n/a	n/a	n/a	n/a
Washington University School of Medicine Curated by ChEMBL					Assay Description Binding affinity to human alpha-synuclein expressed in Escherichia coli BL21 (DE3) cells after 1 hr by thioflavin T fluorescence assay				Bioorg Med Chem 20: 4625-34 (2012) Article DOI: 10.1016/j.bmc.2012.06.023 BindingDB Entry DOI: 10.7270/Q25B03J1
					More data for this Ligand-Target Pair
Alpha-synuclein (Homo sapiens (Human))	BDBM510819 (N-(1-(1H-Indol-3-yl)hexan-2- yl)-5-(4-methylpipera...) Show SMILES CCCCC(Cc1c[nH]c2ccccc12)NC(=O)c1nnc(o1)N1CCN(C)CC1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The fluorescence polarization assay tests the ability of compounds to inhibit the self-aggregation of α-synuclein peptide fragments. Peptides we...				Citation and Details BindingDB Entry DOI: 10.7270/Q2NV9NDS
					More data for this Ligand-Target Pair
Alpha-synuclein (Homo sapiens (Human))	BDBM510818 (N-(1-(1H-Indol-3-yl)hexan-2- yl)-2-(4-methylpipera...) Show SMILES CCCCC(Cc1c[nH]c2ccccc12)NC(=O)c1cnc(o1)N1CCN(C)CC1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	390	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The fluorescence polarization assay tests the ability of compounds to inhibit the self-aggregation of α-synuclein peptide fragments. Peptides we...				Citation and Details BindingDB Entry DOI: 10.7270/Q2NV9NDS
					More data for this Ligand-Target Pair
Alpha-synuclein (Homo sapiens (Human))	BDBM510822 ((S)-N-(1-(1H-Indol-3-yl)hexan- 2-yl)-2-(4-methylpi...) Show SMILES CCCC[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cnc(s1)N1CCN(C)CC1 |r| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	MCE PC cid PC sid UniChem	US Patent	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The fluorescence polarization assay tests the ability of compounds to inhibit the self-aggregation of α-synuclein peptide fragments. Peptides we...				Citation and Details BindingDB Entry DOI: 10.7270/Q2NV9NDS
					More data for this Ligand-Target Pair
Alpha-synuclein (Homo sapiens (Human))	BDBM481754 (N-[1-(1H-indol-3- ylmethyl)pentyl]-2-(4- phenylpip...) Show SMILES CCCCC(Cc1c[nH]c2ccccc12)NC(=O)c1cnc(s1)N1CCN(CC1)c1ccccc1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	US Patent	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
UCB Biopharma SRL US Patent					Assay Description The fluorescence polarization assay tests the ability of compounds to inhibit the self-aggregation of α-synuclein peptide fragments. Peptides we...				US Patent US10913735 (2021) BindingDB Entry DOI: 10.7270/Q25Q507F
					More data for this Ligand-Target Pair
Alpha-synuclein (Homo sapiens (Human))	BDBM50389296 (CHEMBL2063789) Show SMILES [O-][N+](=O)c1ccc2Nc3ccc(I)cc3Sc2c1 Show InChI InChI=1S/C12H7IN2O2S/c13-7-1-3-9-11(5-7)18-12-6-8(15(16)17)2-4-10(12)14-9/h1-6,14H	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	442	n/a	n/a	n/a	n/a	n/a	n/a
Washington University School of Medicine Curated by ChEMBL					Assay Description Binding affinity to human alpha-synuclein expressed in Escherichia coli BL21 (DE3) cells after 1 hr by thioflavin T fluorescence assay				Bioorg Med Chem 20: 4625-34 (2012) Article DOI: 10.1016/j.bmc.2012.06.023 BindingDB Entry DOI: 10.7270/Q25B03J1
					More data for this Ligand-Target Pair
Alpha-synuclein (Homo sapiens (Human))	BDBM50389291 (CHEMBL1976750) Show SMILES [O-][N+](=O)c1ccc2Nc3ccccc3Sc2c1 Show InChI InChI=1S/C12H8N2O2S/c15-14(16)8-5-6-10-12(7-8)17-11-4-2-1-3-9(11)13-10/h1-7,13H	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	485	n/a	n/a	n/a	n/a	n/a	n/a
Washington University School of Medicine Curated by ChEMBL					Assay Description Binding affinity to human alpha-synuclein expressed in Escherichia coli BL21 (DE3) cells after 1 hr by thioflavin T fluorescence assay				Bioorg Med Chem 20: 4625-34 (2012) Article DOI: 10.1016/j.bmc.2012.06.023 BindingDB Entry DOI: 10.7270/Q25B03J1
					More data for this Ligand-Target Pair
Alpha-synuclein (Homo sapiens (Human))	BDBM50389292 (CHEMBL2063785) Show SMILES COc1ccc2Nc3ccc(OC)cc3Sc2c1 Show InChI InChI=1S/C14H13NO2S/c1-16-9-3-5-11-13(7-9)18-14-8-10(17-2)4-6-12(14)15-11/h3-8,15H,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	507	n/a	n/a	n/a	n/a	n/a	n/a
Washington University School of Medicine Curated by ChEMBL					Assay Description Binding affinity to human alpha-synuclein expressed in Escherichia coli BL21 (DE3) cells after 1 hr by thioflavin T fluorescence assay				Bioorg Med Chem 20: 4625-34 (2012) Article DOI: 10.1016/j.bmc.2012.06.023 BindingDB Entry DOI: 10.7270/Q25B03J1
					More data for this Ligand-Target Pair
Alpha-synuclein (Homo sapiens (Human))	BDBM55121 (3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...) Show SMILES NCCc1ccc(O)c(O)c1 Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase DrugBank KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	530	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of alpha-synuclein fibril formation (unknown origin) incubated for 6 days by thioflavin S based fluorescence assay				Citation and Details Article DOI: 10.1016/j.ejmech.2019.01.045 BindingDB Entry DOI: 10.7270/Q2H998V9
					More data for this Ligand-Target Pair
Alpha-synuclein (Homo sapiens (Human))	BDBM510823 ((R)-N-(1-(1H-Indol-3-yl)hexan- 2-yl)-2-(4-methylpi...) Show SMILES CCCC[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1cnc(s1)N1CCN(C)CC1 |r| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The fluorescence polarization assay tests the ability of compounds to inhibit the self-aggregation of α-synuclein peptide fragments. Peptides we...				Citation and Details BindingDB Entry DOI: 10.7270/Q2NV9NDS
					More data for this Ligand-Target Pair
Alpha-synuclein (Homo sapiens (Human))	BDBM50214744 ((2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic aci...) Show SMILES COc1cc(\C=C\C(O)=O)ccc1O Show InChI InChI=1S/C10H10O4/c1-14-9-6-7(2-4-8(9)11)3-5-10(12)13/h2-6,11H,1H3,(H,12,13)/b5-3+	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	750	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of alpha-synuclein fibril formation (unknown origin) incubated for 24 hrs to 7 days by thioflavin S based fluorescence assay				Citation and Details Article DOI: 10.1016/j.ejmech.2019.01.045 BindingDB Entry DOI: 10.7270/Q2H998V9
					More data for this Ligand-Target Pair
Alpha-synuclein (Homo sapiens (Human))	BDBM510820 (N-(1-(1H-Indol-3-yl)hexan-2- yl)-5-(4-methylpipera...) Show SMILES CCCCC(Cc1c[nH]c2ccccc12)NC(=O)c1nnc([nH]1)N1CCN(C)CC1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	770	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The fluorescence polarization assay tests the ability of compounds to inhibit the self-aggregation of α-synuclein peptide fragments. Peptides we...				Citation and Details BindingDB Entry DOI: 10.7270/Q2NV9NDS
					More data for this Ligand-Target Pair
Alpha-synuclein (Homo sapiens (Human))	BDBM481757 (N-[1-(1H-indol-3- ylmethyl)pentyl]-2-[4-(1- methyl...) Show SMILES CCCCC(Cc1c[nH]c2ccccc12)NC(=O)c1cnc(s1)N1CCN(CC1)c1cnn(C)c1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
UCB Biopharma SRL US Patent					Assay Description The fluorescence polarization assay tests the ability of compounds to inhibit the self-aggregation of α-synuclein peptide fragments. Peptides we...				US Patent US10913735 (2021) BindingDB Entry DOI: 10.7270/Q25Q507F
					More data for this Ligand-Target Pair
Alpha-synuclein (Homo sapiens (Human))	BDBM23417 (α-CA inhibitor, 4 | (-)-Epicatechin | (2R,3R)...) Show SMILES O[C@@H]1Cc2c(O)cc(O)cc2O[C@@H]1c1ccc(O)c(O)c1 |r| Show InChI InChI=1S/C15H14O6/c16-8-4-11(18)9-6-13(20)15(21-14(9)5-8)7-1-2-10(17)12(19)3-7/h1-5,13,15-20H,6H2/t13-,15-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of alpha-synuclein fibril formation (unknown origin) incubated for 24 hrs to 7 days by thioflavin S based fluorescence assay				Citation and Details Article DOI: 10.1016/j.ejmech.2019.01.045 BindingDB Entry DOI: 10.7270/Q2H998V9
					More data for this Ligand-Target Pair
Alpha-synuclein (Homo sapiens (Human))	BDBM491842 (N-(1-(1H-indol-3- yl)hexan-2-yl)- 2-(4-isobutyl- p...) Show SMILES CCCCC(Cc1c[nH]c2ccccc12)NC(=O)c1cnc(s1)N1CCN(CC(C)C)CC1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	900	n/a	n/a	n/a	n/a	n/a	n/a
UCB Biopharma SRL US Patent					Assay Description The fluorescence polarization assay tests the ability of compounds to inhibit the self-aggregation of α-synuclein peptide fragments. Peptides we...				US Patent US10975066 (2021) BindingDB Entry DOI: 10.7270/Q26W9F6X
					More data for this Ligand-Target Pair
Alpha-synuclein (Homo sapiens (Human))	BDBM481758 (N-[1-(1H-indol-3- ylmethyl)pentyl]-2-[4-(2- methyl...) Show SMILES CCCCC(Cc1c[nH]c2ccccc12)NC(=O)c1cnc(s1)N1CCN(CC1)c1ccnn1C Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	900	n/a	n/a	n/a	n/a	n/a	n/a
UCB Biopharma SRL US Patent					Assay Description The fluorescence polarization assay tests the ability of compounds to inhibit the self-aggregation of α-synuclein peptide fragments. Peptides we...				US Patent US10913735 (2021) BindingDB Entry DOI: 10.7270/Q25Q507F
					More data for this Ligand-Target Pair
Alpha-synuclein (Homo sapiens (Human))	BDBM481749 (N-[1-(1H-indol-3- ylmethyl)pentyl]-2-[4-(2- pyridy...) Show SMILES CCCCC(Cc1c[nH]c2ccccc12)NC(=O)c1cnc(s1)N1CCN(CC1)c1ccccn1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	900	n/a	n/a	n/a	n/a	n/a	n/a
UCB Biopharma SRL US Patent					Assay Description The fluorescence polarization assay tests the ability of compounds to inhibit the self-aggregation of α-synuclein peptide fragments. Peptides we...				US Patent US10913735 (2021) BindingDB Entry DOI: 10.7270/Q25Q507F
					More data for this Ligand-Target Pair
Alpha-synuclein (Homo sapiens (Human))	BDBM50544150 (CHEMBL4641523) Show SMILES Oc1ccc(cc1)C(=O)Nc1ccc(NC(=O)c2cc(O)c(O)c(O)c2)cc1 Show InChI InChI=1S/C20H16N2O6/c23-15-7-1-11(2-8-15)19(27)21-13-3-5-14(6-4-13)22-20(28)12-9-16(24)18(26)17(25)10-12/h1-10,23-26H,(H,21,27)(H,22,28)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	980	n/a	n/a	n/a	n/a	n/a	n/a
Zhengzhou University Curated by ChEMBL					Assay Description Inhibition of alpha-synuclein (unknown origin) aggregation incubated for 3 days by thioflavin T based fluorescence assay				Bioorg Med Chem 28: (2020) Article DOI: 10.1016/j.bmc.2020.115596 BindingDB Entry DOI: 10.7270/Q2ST7TD0
					More data for this Ligand-Target Pair
Alpha-synuclein (Homo sapiens (Human))	BDBM491847 (N-(1-(1H-indol-3- yl)hexan-2-yl)-2- (4-(3,3,3-trif...) Show SMILES CCCCC(Cc1c[nH]c2ccccc12)NC(=O)c1cnc(s1)N1CCN(CCC(F)(F)F)CC1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
UCB Biopharma SRL US Patent					Assay Description The fluorescence polarization assay tests the ability of compounds to inhibit the self-aggregation of α-synuclein peptide fragments. Peptides we...				US Patent US10975066 (2021) BindingDB Entry DOI: 10.7270/Q26W9F6X
					More data for this Ligand-Target Pair
Alpha-synuclein (Homo sapiens (Human))	BDBM491846 (N-(1-(1H-indol-3- yl)hexan-2-yl)-2- (4-(2,2,2-trif...) Show SMILES CCCCC(Cc1c[nH]c2ccccc12)NC(=O)c1cnc(s1)N1CCN(CC(F)(F)F)CC1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
UCB Biopharma SRL US Patent					Assay Description The fluorescence polarization assay tests the ability of compounds to inhibit the self-aggregation of α-synuclein peptide fragments. Peptides we...				US Patent US10975066 (2021) BindingDB Entry DOI: 10.7270/Q26W9F6X
					More data for this Ligand-Target Pair
Alpha-synuclein (Homo sapiens (Human))	BDBM481756 (N-[1-(1H-indol-3- ylmethyl)pentyl]-2-[4-(1H- pyraz...) Show SMILES CCCCC(Cc1c[nH]c2ccccc12)NC(=O)c1cnc(s1)N1CCN(CC1)c1ccn[nH]1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
UCB Biopharma SRL US Patent					Assay Description The fluorescence polarization assay tests the ability of compounds to inhibit the self-aggregation of α-synuclein peptide fragments. Peptides we...				US Patent US10913735 (2021) BindingDB Entry DOI: 10.7270/Q25Q507F
					More data for this Ligand-Target Pair
Alpha-synuclein (Homo sapiens (Human))	BDBM481745 (N-[1-(1H-indol-3- ylmethyl)pentyl]-2-(4- pyrimidin...) Show SMILES CCCCC(Cc1c[nH]c2ccccc12)NC(=O)c1cnc(s1)N1CCN(CC1)c1ncccn1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
UCB Biopharma SRL US Patent					Assay Description The fluorescence polarization assay tests the ability of compounds to inhibit the self-aggregation of α-synuclein peptide fragments. Peptides we...				US Patent US10913735 (2021) BindingDB Entry DOI: 10.7270/Q25Q507F
					More data for this Ligand-Target Pair
Alpha-synuclein (Homo sapiens (Human))	BDBM481747 (N-[1-(1H-indol-3- ylmethyl)pentyl]-2-[4-(3- pyridy...) Show SMILES CCCCC(Cc1c[nH]c2ccccc12)NC(=O)c1cnc(s1)N1CCN(CC1)c1cccnc1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
UCB Biopharma SRL US Patent					Assay Description The fluorescence polarization assay tests the ability of compounds to inhibit the self-aggregation of α-synuclein peptide fragments. Peptides we...				US Patent US10913735 (2021) BindingDB Entry DOI: 10.7270/Q25Q507F
					More data for this Ligand-Target Pair
Alpha-synuclein (Homo sapiens (Human))	BDBM50510750 (CHEMBL4551721) Show SMILES [O-][N+](=O)c1ccc2[nH]c(\C=C\C=C\c3ccccn3)nc2c1 Show InChI InChI=1S/C16H12N4O2/c21-20(22)13-8-9-14-15(11-13)19-16(18-14)7-2-1-5-12-6-3-4-10-17-12/h1-11H,(H,18,19)/b5-1+,7-2+	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.09E+3	n/a	n/a	n/a	n/a	n/a	n/a
Zhengzhou University Curated by ChEMBL					Assay Description Inhibition of alpha-synuclein aggregation (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 3 days by thioflavin T fluorescence...				Bioorg Med Chem 27: 3089-3096 (2019) Article DOI: 10.1016/j.bmc.2019.05.032 BindingDB Entry DOI: 10.7270/Q290274V
					More data for this Ligand-Target Pair
Alpha-synuclein (Homo sapiens (Human))	BDBM491840 (N-(1-(1H-indol-3- yl)hexan-2-yl)-2- (4-cyclopropyl...) Show SMILES CCCCC(Cc1c[nH]c2ccccc12)NC(=O)c1cnc(s1)N1CCN(CC1)C1CC1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
UCB Biopharma SRL US Patent					Assay Description The fluorescence polarization assay tests the ability of compounds to inhibit the self-aggregation of α-synuclein peptide fragments. Peptides we...				US Patent US10975066 (2021) BindingDB Entry DOI: 10.7270/Q26W9F6X
					More data for this Ligand-Target Pair
Alpha-synuclein (Homo sapiens (Human))	BDBM491843 (N-(1-(1H-indol-3- yl)hexan-2-yl)- 2-(4-(2-methoxy-...) Show SMILES CCCCC(Cc1c[nH]c2ccccc12)NC(=O)c1cnc(s1)N1CCN(CCOC)CC1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
UCB Biopharma SRL US Patent					Assay Description The fluorescence polarization assay tests the ability of compounds to inhibit the self-aggregation of α-synuclein peptide fragments. Peptides we...				US Patent US10975066 (2021) BindingDB Entry DOI: 10.7270/Q26W9F6X
					More data for this Ligand-Target Pair
Alpha-synuclein (Homo sapiens (Human))	BDBM481755 (N-[1-(1H-indol-3- ylmethyl)pentyl]-2-[4-(1H- pyraz...) Show SMILES CCCCC(Cc1c[nH]c2ccccc12)NC(=O)c1cnc(s1)N1CCN(CC1)c1cn[nH]c1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
UCB Biopharma SRL US Patent					Assay Description The fluorescence polarization assay tests the ability of compounds to inhibit the self-aggregation of α-synuclein peptide fragments. Peptides we...				US Patent US10913735 (2021) BindingDB Entry DOI: 10.7270/Q25Q507F
					More data for this Ligand-Target Pair
Alpha-synuclein (Homo sapiens (Human))	BDBM481750 (N-[1-(1H-indol-3- ylmethyl)pentyl]-2-(4- pyrimidin...) Show SMILES CCCCC(Cc1c[nH]c2ccccc12)NC(=O)c1cnc(s1)N1CCN(CC1)c1ccncn1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
UCB Biopharma SRL US Patent					Assay Description The fluorescence polarization assay tests the ability of compounds to inhibit the self-aggregation of α-synuclein peptide fragments. Peptides we...				US Patent US10913735 (2021) BindingDB Entry DOI: 10.7270/Q25Q507F
					More data for this Ligand-Target Pair
Alpha-synuclein (Homo sapiens (Human))	BDBM491859 (US10975066, Example 24) Show SMILES CCCCC(Cc1c[nH]c2ccccc12)NC(=O)c1cnc(s1)N1C[C@@H](C)N(C)[C@H](C)C1 |r| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
UCB Biopharma SRL US Patent					Assay Description The fluorescence polarization assay tests the ability of compounds to inhibit the self-aggregation of α-synuclein peptide fragments. Peptides we...				US Patent US10975066 (2021) BindingDB Entry DOI: 10.7270/Q26W9F6X
					More data for this Ligand-Target Pair
Alpha-synuclein (Homo sapiens (Human))	BDBM491845 (N-(1-(1H-indol-3- yl)hexan-2-yl)-2- (4-(2,2-difluo...) Show SMILES CCCCC(Cc1c[nH]c2ccccc12)NC(=O)c1cnc(s1)N1CCN(CC(F)F)CC1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
UCB Biopharma SRL US Patent					Assay Description The fluorescence polarization assay tests the ability of compounds to inhibit the self-aggregation of α-synuclein peptide fragments. Peptides we...				US Patent US10975066 (2021) BindingDB Entry DOI: 10.7270/Q26W9F6X
					More data for this Ligand-Target Pair
Alpha-synuclein (Homo sapiens (Human))	BDBM491839 (N-(1-(1H-indol-3- yl)hexan-2-yl)-2-(4- isopropylpi...) Show SMILES CCCCC(Cc1c[nH]c2ccccc12)NC(=O)c1cnc(s1)N1CCN(CC1)C(C)C Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
UCB Biopharma SRL US Patent					Assay Description The fluorescence polarization assay tests the ability of compounds to inhibit the self-aggregation of α-synuclein peptide fragments. Peptides we...				US Patent US10975066 (2021) BindingDB Entry DOI: 10.7270/Q26W9F6X
					More data for this Ligand-Target Pair
Alpha-synuclein (Homo sapiens (Human))	BDBM491844 (N-(1-(1H-indol-3- yl)hexan-2-yl)-2- (4-(2-fluoroet...) Show SMILES CCCCC(Cc1c[nH]c2ccccc12)NC(=O)c1cnc(s1)N1CCN(CCF)CC1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
UCB Biopharma SRL US Patent					Assay Description The fluorescence polarization assay tests the ability of compounds to inhibit the self-aggregation of α-synuclein peptide fragments. Peptides we...				US Patent US10975066 (2021) BindingDB Entry DOI: 10.7270/Q26W9F6X
					More data for this Ligand-Target Pair
Alpha-synuclein (Homo sapiens (Human))	BDBM481753 (N-[1-(1H-indol-3- ylmethyl)pentyl]-2-(4- pyrazin-2...) Show SMILES CCCCC(Cc1c[nH]c2ccccc12)NC(=O)c1cnc(s1)N1CCN(CC1)c1cnccn1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
UCB Biopharma SRL US Patent					Assay Description The fluorescence polarization assay tests the ability of compounds to inhibit the self-aggregation of α-synuclein peptide fragments. Peptides we...				US Patent US10913735 (2021) BindingDB Entry DOI: 10.7270/Q25Q507F
					More data for this Ligand-Target Pair
Alpha-synuclein (Homo sapiens (Human))	BDBM491850 (N-(1-(1H-indol- 3-yl)hexan-2-yl)- 2-(cis-3,4,5- tr...) Show SMILES CCCCC(Cc1c[nH]c2ccccc12)NC(=O)c1cnc(s1)N1C[C@H](C)N(C)[C@H](C)C1 |r| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
UCB Biopharma SRL US Patent					Assay Description The fluorescence polarization assay tests the ability of compounds to inhibit the self-aggregation of α-synuclein peptide fragments. Peptides we...				US Patent US10975066 (2021) BindingDB Entry DOI: 10.7270/Q26W9F6X
					More data for this Ligand-Target Pair
Alpha-synuclein (Homo sapiens (Human))	BDBM491853 (N-(2-(1H-indol-3- yl)ethyl)-N-butyl- 2-(4-methyl- ...) Show SMILES CCCCN(CCc1c[nH]c2ccccc12)C(=O)c1cnc(s1)N1CCN(C)CC1 Show InChI InChI=1S/C23H31N5OS/c1-3-4-10-27(11-9-18-16-24-20-8-6-5-7-19(18)20)22(29)21-17-25-23(30-21)28-14-12-26(2)13-15-28/h5-8,16-17,24H,3-4,9-15H2,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
UCB Biopharma SRL US Patent					Assay Description The fluorescence polarization assay tests the ability of compounds to inhibit the self-aggregation of α-synuclein peptide fragments. Peptides we...				US Patent US10975066 (2021) BindingDB Entry DOI: 10.7270/Q26W9F6X
					More data for this Ligand-Target Pair
Alpha-synuclein (Homo sapiens (Human))	BDBM50544151 (CHEMBL4640362) Show SMILES Cc1ccc(cc1)S(=O)(=O)Nc1ccc(NC(=O)c2cc(O)c(O)c(O)c2)cc1 Show InChI InChI=1S/C20H18N2O6S/c1-12-2-8-16(9-3-12)29(27,28)22-15-6-4-14(5-7-15)21-20(26)13-10-17(23)19(25)18(24)11-13/h2-11,22-25H,1H3,(H,21,26)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.22E+3	n/a	n/a	n/a	n/a	n/a	n/a
Zhengzhou University Curated by ChEMBL					Assay Description Inhibition of alpha-synuclein (unknown origin) aggregation incubated for 3 days by thioflavin T based fluorescence assay				Bioorg Med Chem 28: (2020) Article DOI: 10.1016/j.bmc.2020.115596 BindingDB Entry DOI: 10.7270/Q2ST7TD0
					More data for this Ligand-Target Pair

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