Compile Data Set for Download or QSAR

Found 228 hits of ic50 for UniProtKB: P36894   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bone morphogenetic protein receptor type-1A [198-525] (Homo sapiens (Human))	BDBM518855 (US11160797, Example 1 | US11160797, Example 26 | U...) Show SMILES CC(C)n1cc(ccc1=O)-c1cncc(c1)-c1ccc2N(C)C(=O)Cc2c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Example 53: The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were g...				Citation and Details BindingDB Entry DOI: 10.7270/Q2M048M3
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A [198-525] (Homo sapiens (Human))	BDBM451789 (US10710980, Example 21 | US10947218, Example 21) Show SMILES Nc1ncc(cc1C(=O)N[C@@H]1CC[C@@H](O)[C@@H](F)C1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(C2)C1CCOCC1 |r| Show InChI InChI=1S/C28H35FN4O3/c29-24-12-21(5-6-25(24)34)32-27(35)23-11-18(14-31-26(23)30)17-1-3-19(4-2-17)28-13-20(28)15-33(16-28)22-7-9-36-10-8-22/h1-4,11,14,20-22,24-25,34H,5-10,12-13,15-16H2,(H2,30,31)(H,32,35)/t20-,21-,24+,25-,28+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were generated by ...				US Patent US10710980 (2020) BindingDB Entry DOI: 10.7270/Q2DF6V81
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A [198-525] (Homo sapiens (Human))	BDBM451789 (US10710980, Example 21 | US10947218, Example 21) Show SMILES Nc1ncc(cc1C(=O)N[C@@H]1CC[C@@H](O)[C@@H](F)C1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(C2)C1CCOCC1 |r| Show InChI InChI=1S/C28H35FN4O3/c29-24-12-21(5-6-25(24)34)32-27(35)23-11-18(14-31-26(23)30)17-1-3-19(4-2-17)28-13-20(28)15-33(16-28)22-7-9-36-10-8-22/h1-4,11,14,20-22,24-25,34H,5-10,12-13,15-16H2,(H2,30,31)(H,32,35)/t20-,21-,24+,25-,28+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49...				US Patent US10947218 (2021) BindingDB Entry DOI: 10.7270/Q24F1TVV
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A [198-525] (Homo sapiens (Human))	BDBM522140 (US11160797, Example 48) Show SMILES CC(C)n1cc(ccc1=O)-c1cncc(c1)-c1ccc2N(C)S(=O)(=O)Cc2c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	283	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Example 53: The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were g...				Citation and Details BindingDB Entry DOI: 10.7270/Q2M048M3
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A [198-525] (Homo sapiens (Human))	BDBM522116 (US11160797, Example 24) Show SMILES CC(C)CN1C(=O)Cc2cc(ccc12)-c1cncc(c1)-c1ccc(=O)n(c1)C(C)C Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Example 53: The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were g...				Citation and Details BindingDB Entry DOI: 10.7270/Q2M048M3
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A [198-525] (Homo sapiens (Human))	BDBM451769 (US10710980, Example 1 | US10947218, Example 1) Show SMILES CS(=O)(=O)N1CCC(CC1)N1C[C@H]2C[C@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:14.18,32.36,wD:12.13,35.40,(7.28,-6.06,;8.77,-5.66,;8.77,-7.2,;10.26,-5.27,;8.14,-4.26,;6.61,-4.1,;5.99,-2.69,;6.89,-1.44,;8.42,-1.6,;9.05,-3.01,;6.27,-.04,;7.04,1.3,;6,2.44,;4.76,3.35,;4.6,1.81,;4.76,.28,;3.26,2.58,;1.93,1.81,;.6,2.58,;.6,4.12,;1.93,4.89,;3.26,4.12,;-.74,4.89,;-.74,6.43,;-2.07,7.2,;-3.4,6.43,;-4.74,7.2,;-3.4,4.89,;-2.07,4.12,;-4.74,4.12,;-6.07,4.89,;-4.74,2.58,;-6.07,1.81,;-6.21,.28,;-7.6,-.37,;-8.86,.51,;-10.26,-.14,;-8.73,2.05,;-7.33,2.7,)| Show InChI InChI=1S/C29H39N5O4S/c1-39(37,38)34-12-10-24(11-13-34)33-17-22-15-29(22,18-33)21-4-2-19(3-5-21)20-14-26(27(30)31-16-20)28(36)32-23-6-8-25(35)9-7-23/h2-5,14,16,22-25,35H,6-13,15,17-18H2,1H3,(H2,30,31)(H,32,36)/t22-,23-,25-,29+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	310	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were generated by ...				US Patent US10710980 (2020) BindingDB Entry DOI: 10.7270/Q2DF6V81
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A [198-525] (Homo sapiens (Human))	BDBM451769 (US10710980, Example 1 | US10947218, Example 1) Show SMILES CS(=O)(=O)N1CCC(CC1)N1C[C@H]2C[C@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:14.18,32.36,wD:12.13,35.40,(7.28,-6.06,;8.77,-5.66,;8.77,-7.2,;10.26,-5.27,;8.14,-4.26,;6.61,-4.1,;5.99,-2.69,;6.89,-1.44,;8.42,-1.6,;9.05,-3.01,;6.27,-.04,;7.04,1.3,;6,2.44,;4.76,3.35,;4.6,1.81,;4.76,.28,;3.26,2.58,;1.93,1.81,;.6,2.58,;.6,4.12,;1.93,4.89,;3.26,4.12,;-.74,4.89,;-.74,6.43,;-2.07,7.2,;-3.4,6.43,;-4.74,7.2,;-3.4,4.89,;-2.07,4.12,;-4.74,4.12,;-6.07,4.89,;-4.74,2.58,;-6.07,1.81,;-6.21,.28,;-7.6,-.37,;-8.86,.51,;-10.26,-.14,;-8.73,2.05,;-7.33,2.7,)| Show InChI InChI=1S/C29H39N5O4S/c1-39(37,38)34-12-10-24(11-13-34)33-17-22-15-29(22,18-33)21-4-2-19(3-5-21)20-14-26(27(30)31-16-20)28(36)32-23-6-8-25(35)9-7-23/h2-5,14,16,22-25,35H,6-13,15,17-18H2,1H3,(H2,30,31)(H,32,36)/t22-,23-,25-,29+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	310	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49...				US Patent US10947218 (2021) BindingDB Entry DOI: 10.7270/Q24F1TVV
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A [198-525] (Homo sapiens (Human))	BDBM522131 (US11160797, Example 39) Show SMILES CC(C)n1cc(ccc1=O)-c1cncc(c1)-c1ccc2N(C)C(=O)CCCc2c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Example 53: The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were g...				Citation and Details BindingDB Entry DOI: 10.7270/Q2M048M3
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A [198-525] (Homo sapiens (Human))	BDBM451813 (US10710980, Example 44 | US10947218, Example 44) Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(C2)C1CCS(=O)(=O)CC1 |r,wU:23.25,10.10,wD:25.27,13.14,(-4.13,6.5,;-2.8,5.73,;-1.47,6.5,;-.13,5.73,;-.13,4.19,;-1.47,3.42,;-2.8,4.19,;-4.13,3.42,;-5.47,4.19,;-4.13,1.88,;-5.62,1.48,;-6.02,-.01,;-7.51,-.4,;-8.6,.69,;-10.08,.29,;-8.2,2.17,;-6.71,2.57,;1.2,3.42,;1.2,1.88,;2.54,1.11,;3.87,1.88,;3.87,3.42,;2.54,4.19,;5.2,1.11,;5.36,2.64,;6.61,1.74,;7.64,.59,;6.87,-.74,;5.36,-.42,;7.5,-2.15,;6.59,-3.39,;7.22,-4.8,;8.75,-4.96,;10.08,-5.73,;8.75,-6.5,;9.65,-3.72,;9.03,-2.31,)| Show InChI InChI=1S/C28H36N4O4S/c29-26-25(27(34)31-22-5-7-24(33)8-6-22)13-19(15-30-26)18-1-3-20(4-2-18)28-14-21(28)16-32(17-28)23-9-11-37(35,36)12-10-23/h1-4,13,15,21-24,33H,5-12,14,16-17H2,(H2,29,30)(H,31,34)/t21-,22-,24-,28+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	430	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were generated by ...				US Patent US10710980 (2020) BindingDB Entry DOI: 10.7270/Q2DF6V81
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A [198-525] (Homo sapiens (Human))	BDBM451813 (US10710980, Example 44 | US10947218, Example 44) Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(C2)C1CCS(=O)(=O)CC1 |r,wU:23.25,10.10,wD:25.27,13.14,(-4.13,6.5,;-2.8,5.73,;-1.47,6.5,;-.13,5.73,;-.13,4.19,;-1.47,3.42,;-2.8,4.19,;-4.13,3.42,;-5.47,4.19,;-4.13,1.88,;-5.62,1.48,;-6.02,-.01,;-7.51,-.4,;-8.6,.69,;-10.08,.29,;-8.2,2.17,;-6.71,2.57,;1.2,3.42,;1.2,1.88,;2.54,1.11,;3.87,1.88,;3.87,3.42,;2.54,4.19,;5.2,1.11,;5.36,2.64,;6.61,1.74,;7.64,.59,;6.87,-.74,;5.36,-.42,;7.5,-2.15,;6.59,-3.39,;7.22,-4.8,;8.75,-4.96,;10.08,-5.73,;8.75,-6.5,;9.65,-3.72,;9.03,-2.31,)| Show InChI InChI=1S/C28H36N4O4S/c29-26-25(27(34)31-22-5-7-24(33)8-6-22)13-19(15-30-26)18-1-3-20(4-2-18)28-14-21(28)16-32(17-28)23-9-11-37(35,36)12-10-23/h1-4,13,15,21-24,33H,5-12,14,16-17H2,(H2,29,30)(H,31,34)/t21-,22-,24-,28+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	430	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49...				US Patent US10947218 (2021) BindingDB Entry DOI: 10.7270/Q24F1TVV
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A [198-525] (Homo sapiens (Human))	BDBM522122 (US11160797, Example 30) Show SMILES COCCCN1C(=O)Cc2cc(ccc12)-c1cncc(c1)-c1ccc(=O)n(c1)C(C)C Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	450	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Example 53: The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were g...				Citation and Details BindingDB Entry DOI: 10.7270/Q2M048M3
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A [198-525] (Homo sapiens (Human))	BDBM522117 (US11160797, Example 25) Show SMILES CCCN1C(=O)Cc2cc(ccc12)-c1cncc(c1)-c1ccc(=O)n(c1)C(C)C Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	490	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Example 53: The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were g...				Citation and Details BindingDB Entry DOI: 10.7270/Q2M048M3
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A [198-525] (Homo sapiens (Human))	BDBM451798 (US10710980, Example 30 | US10947218, Example 30) Show SMILES Nc1ncc(cc1C(=O)NC12CC(CO)(C1)C2)-c1ccc(cc1)[C@@]12C[C@@H]1CN(C2)C1CCOCC1 |r| Show InChI InChI=1S/C28H34N4O3/c29-24-23(25(34)31-27-13-26(14-27,15-27)17-33)9-19(11-30-24)18-1-3-20(4-2-18)28-10-21(28)12-32(16-28)22-5-7-35-8-6-22/h1-4,9,11,21-22,33H,5-8,10,12-17H2,(H2,29,30)(H,31,34)/t21-,26?,27?,28+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were generated by ...				US Patent US10710980 (2020) BindingDB Entry DOI: 10.7270/Q2DF6V81
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A [198-525] (Homo sapiens (Human))	BDBM522065 (US11160797, Example 3) Show SMILES CC(C)n1cc(cc(C)c1=O)-c1cncc(c1)-c1ccc2N(C)C(=O)Cc2c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Example 53: The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were g...				Citation and Details BindingDB Entry DOI: 10.7270/Q2M048M3
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A [198-525] (Homo sapiens (Human))	BDBM451798 (US10710980, Example 30 | US10947218, Example 30) Show SMILES Nc1ncc(cc1C(=O)NC12CC(CO)(C1)C2)-c1ccc(cc1)[C@@]12C[C@@H]1CN(C2)C1CCOCC1 |r| Show InChI InChI=1S/C28H34N4O3/c29-24-23(25(34)31-27-13-26(14-27,15-27)17-33)9-19(11-30-24)18-1-3-20(4-2-18)28-10-21(28)12-32(16-28)22-5-7-35-8-6-22/h1-4,9,11,21-22,33H,5-8,10,12-17H2,(H2,29,30)(H,31,34)/t21-,26?,27?,28+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49...				US Patent US10947218 (2021) BindingDB Entry DOI: 10.7270/Q24F1TVV
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A [198-525] (Homo sapiens (Human))	BDBM522124 (US11160797, Example 32) Show SMILES CC(C)n1cc(ccc1=O)-c1cncc(c1)-c1ccc2c(NC(=O)C2(C)C)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	510	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Example 53: The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were g...				Citation and Details BindingDB Entry DOI: 10.7270/Q2M048M3
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A [198-525] (Homo sapiens (Human))	BDBM518855 (US11160797, Example 1 | US11160797, Example 26 | U...) Show SMILES CC(C)n1cc(ccc1=O)-c1cncc(c1)-c1ccc2N(C)C(=O)Cc2c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	520	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Example 53: The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were g...				Citation and Details BindingDB Entry DOI: 10.7270/Q2M048M3
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A [198-525] (Homo sapiens (Human))	BDBM518859 (US11160797, Example 2) Show SMILES COc1cc(cn(C(C)C)c1=O)-c1cncc(c1)-c1ccc2N(C)C(=O)Cc2c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	520	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Example 53: The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were g...				Citation and Details BindingDB Entry DOI: 10.7270/Q2M048M3
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A [198-525] (Homo sapiens (Human))	BDBM522123 (US11160797, Example 31) Show SMILES CC(C)n1cc(ccc1=O)-c1cncc(c1)-c1cc2CC(=O)N(C)c2cc1F Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	520	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Example 53: The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were g...				Citation and Details BindingDB Entry DOI: 10.7270/Q2M048M3
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A [198-525] (Homo sapiens (Human))	BDBM451796 (US10710980, Example 28 | US10947218, Example 28) Show SMILES Nc1ncc(cc1C(=O)NC12CC(CO)(C1)C2)-c1ccc(cc1)[C@]12C[C@H]1CN(C2)C1CCOCC1 |r| Show InChI InChI=1S/C28H34N4O3/c29-24-23(25(34)31-27-13-26(14-27,15-27)17-33)9-19(11-30-24)18-1-3-20(4-2-18)28-10-21(28)12-32(16-28)22-5-7-35-8-6-22/h1-4,9,11,21-22,33H,5-8,10,12-17H2,(H2,29,30)(H,31,34)/t21-,26?,27?,28+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	530	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were generated by ...				US Patent US10710980 (2020) BindingDB Entry DOI: 10.7270/Q2DF6V81
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A [198-525] (Homo sapiens (Human))	BDBM451796 (US10710980, Example 28 | US10947218, Example 28) Show SMILES Nc1ncc(cc1C(=O)NC12CC(CO)(C1)C2)-c1ccc(cc1)[C@]12C[C@H]1CN(C2)C1CCOCC1 |r| Show InChI InChI=1S/C28H34N4O3/c29-24-23(25(34)31-27-13-26(14-27,15-27)17-33)9-19(11-30-24)18-1-3-20(4-2-18)28-10-21(28)12-32(16-28)22-5-7-35-8-6-22/h1-4,9,11,21-22,33H,5-8,10,12-17H2,(H2,29,30)(H,31,34)/t21-,26?,27?,28+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	530	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49...				US Patent US10947218 (2021) BindingDB Entry DOI: 10.7270/Q24F1TVV
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A [198-525] (Homo sapiens (Human))	BDBM522130 (US11160797, Example 38) Show SMILES CC(C)n1cc(ccc1=O)-c1cncc(c1)-c1ccc2N(CC3CCC3)C(=O)Cc2c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	540	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Example 53: The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were g...				Citation and Details BindingDB Entry DOI: 10.7270/Q2M048M3
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A [198-525] (Homo sapiens (Human))	BDBM522113 (US11160797, Example 21) Show SMILES CC(C)N1C(=O)Cc2cc(ccc12)-c1cncc(c1)-c1ccc(=O)n(c1)C(C)C Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	570	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Example 53: The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were g...				Citation and Details BindingDB Entry DOI: 10.7270/Q2M048M3
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A [198-525] (Homo sapiens (Human))	BDBM522135 (US11160797, Example 43) Show SMILES CC(C)n1cc(ccc1=O)-c1nc(cnc1N)-c1ccc2N(C)C(=O)Cc2c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Example 53: The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were g...				Citation and Details BindingDB Entry DOI: 10.7270/Q2M048M3
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A [198-525] (Homo sapiens (Human))	BDBM522112 (US11160797, Example 20) Show SMILES CCN1C(=O)Cc2cc(ccc12)-c1cncc(c1)-c1ccc(=O)n(c1)C(C)C Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	620	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Example 53: The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were g...				Citation and Details BindingDB Entry DOI: 10.7270/Q2M048M3
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A [198-525] (Homo sapiens (Human))	BDBM522141 (US11160797, Example 49) Show SMILES CCN1c2ccc(cc2CS1(=O)=O)-c1cncc(c1)-c1ccc(=O)n(c1)C(C)C Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	670	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Example 53: The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were g...				Citation and Details BindingDB Entry DOI: 10.7270/Q2M048M3
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A [198-525] (Homo sapiens (Human))	BDBM522127 (US11160797, Example 35) Show SMILES CC(C)n1cc(ccc1=O)-c1cncc(c1)-c1cc2CC(=O)N(C)c2c(C)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Example 53: The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were g...				Citation and Details BindingDB Entry DOI: 10.7270/Q2M048M3
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A [198-525] (Homo sapiens (Human))	BDBM451822 (US10710980, Example 51 | US10947218, Example 51) Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@]12C[C@H]1CN(CCC#N)C2 |r,wU:10.10,25.27,wD:23.25,13.14,(-4.72,5.67,;-3.39,4.9,;-2.05,5.67,;-.72,4.9,;-.72,3.36,;-2.05,2.59,;-3.39,3.36,;-4.72,2.59,;-6.06,3.36,;-4.72,1.05,;-6.06,.28,;-6.19,-1.26,;-7.59,-1.91,;-8.85,-1.03,;-10.07,-1.64,;-8.71,.51,;-7.32,1.16,;.61,2.59,;.61,1.05,;1.95,.28,;3.28,1.05,;3.28,2.59,;1.95,3.36,;4.61,.28,;4.77,1.81,;6.02,.9,;7.05,-.24,;6.28,-1.58,;7.05,-2.91,;8.48,-2.91,;9.25,-4.24,;10.07,-5.67,;4.77,-1.26,)| Show InChI InChI=1S/C26H31N5O2/c27-10-1-11-31-15-20-13-26(20,16-31)19-4-2-17(3-5-19)18-12-23(24(28)29-14-18)25(33)30-21-6-8-22(32)9-7-21/h2-5,12,14,20-22,32H,1,6-9,11,13,15-16H2,(H2,28,29)(H,30,33)/t20-,21-,22-,26+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	780	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were generated by ...				US Patent US10710980 (2020) BindingDB Entry DOI: 10.7270/Q2DF6V81
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A [198-525] (Homo sapiens (Human))	BDBM451822 (US10710980, Example 51 | US10947218, Example 51) Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@]12C[C@H]1CN(CCC#N)C2 |r,wU:10.10,25.27,wD:23.25,13.14,(-4.72,5.67,;-3.39,4.9,;-2.05,5.67,;-.72,4.9,;-.72,3.36,;-2.05,2.59,;-3.39,3.36,;-4.72,2.59,;-6.06,3.36,;-4.72,1.05,;-6.06,.28,;-6.19,-1.26,;-7.59,-1.91,;-8.85,-1.03,;-10.07,-1.64,;-8.71,.51,;-7.32,1.16,;.61,2.59,;.61,1.05,;1.95,.28,;3.28,1.05,;3.28,2.59,;1.95,3.36,;4.61,.28,;4.77,1.81,;6.02,.9,;7.05,-.24,;6.28,-1.58,;7.05,-2.91,;8.48,-2.91,;9.25,-4.24,;10.07,-5.67,;4.77,-1.26,)| Show InChI InChI=1S/C26H31N5O2/c27-10-1-11-31-15-20-13-26(20,16-31)19-4-2-17(3-5-19)18-12-23(24(28)29-14-18)25(33)30-21-6-8-22(32)9-7-21/h2-5,12,14,20-22,32H,1,6-9,11,13,15-16H2,(H2,28,29)(H,30,33)/t20-,21-,22-,26+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	780	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49...				US Patent US10947218 (2021) BindingDB Entry DOI: 10.7270/Q24F1TVV
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A [198-525] (Homo sapiens (Human))	BDBM522132 (US11160797, Example 40) Show SMILES CCC(CC)CN1C(=O)Cc2cc(ccc12)-c1cncc(c1)-c1ccc(=O)n(c1)C(C)C Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Example 53: The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were g...				Citation and Details BindingDB Entry DOI: 10.7270/Q2M048M3
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A [198-525] (Homo sapiens (Human))	BDBM451807 (US10710980, Example 39 | US10947218, Example 39) Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(C2)C1CCN(CC(F)(F)F)CC1 |r,wU:23.25,10.10,wD:25.27,13.14,(-5.29,7.1,;-3.96,6.33,;-2.63,7.1,;-1.29,6.33,;-1.29,4.79,;-2.63,4.02,;-3.96,4.79,;-5.29,4.02,;-6.63,4.79,;-5.29,2.48,;-6.78,2.08,;-7.18,.6,;-8.67,.2,;-9.76,1.29,;-11.24,.89,;-9.36,2.77,;-7.87,3.17,;.04,4.02,;.04,2.48,;1.38,1.71,;2.71,2.48,;2.71,4.02,;1.38,4.79,;4.04,1.71,;4.2,3.24,;5.45,2.34,;6.48,1.19,;5.71,-.14,;4.2,.18,;6.34,-1.55,;5.43,-2.79,;6.06,-4.2,;7.59,-4.36,;8.22,-5.77,;9.76,-5.77,;10.53,-7.1,;10.53,-4.43,;11.24,-5.37,;8.49,-3.12,;7.87,-1.71,)| Show InChI InChI=1S/C30H38F3N5O2/c31-30(32,33)18-37-11-9-24(10-12-37)38-16-22-14-29(22,17-38)21-3-1-19(2-4-21)20-13-26(27(34)35-15-20)28(40)36-23-5-7-25(39)8-6-23/h1-4,13,15,22-25,39H,5-12,14,16-18H2,(H2,34,35)(H,36,40)/t22-,23-,25-,29+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	830	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were generated by ...				US Patent US10710980 (2020) BindingDB Entry DOI: 10.7270/Q2DF6V81
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A [198-525] (Homo sapiens (Human))	BDBM451772 (US10710980, Example 4 | US10947218, Example 4) Show SMILES C[C@H](N1CC2(COC2)C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:1.0,25.28,wD:28.32,(5.54,-3.46,;5.54,-1.92,;6.88,-1.16,;8.36,-1.55,;8.76,-.07,;10.25,-.46,;10.65,1.02,;9.16,1.42,;7.27,.33,;4.21,-1.16,;2.87,-1.92,;1.54,-1.16,;1.54,.38,;2.87,1.16,;4.21,.38,;.21,1.16,;.21,2.7,;-1.13,3.46,;-2.46,2.7,;-3.79,3.46,;-2.46,1.16,;-1.13,.38,;-3.79,.38,;-3.79,-1.16,;-5.13,1.16,;-6.46,.38,;-6.6,-1.15,;-7.99,-1.8,;-9.25,-.92,;-10.65,-1.57,;-9.12,.62,;-7.72,1.27,)| Show InChI InChI=1S/C25H32N4O3/c1-16(29-12-25(13-29)14-32-15-25)17-2-4-18(5-3-17)19-10-22(23(26)27-11-19)24(31)28-20-6-8-21(30)9-7-20/h2-5,10-11,16,20-21,30H,6-9,12-15H2,1H3,(H2,26,27)(H,28,31)/t16-,20-,21-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	830	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were generated by ...				US Patent US10710980 (2020) BindingDB Entry DOI: 10.7270/Q2DF6V81
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A [198-525] (Homo sapiens (Human))	BDBM451772 (US10710980, Example 4 | US10947218, Example 4) Show SMILES C[C@H](N1CC2(COC2)C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:1.0,25.28,wD:28.32,(5.54,-3.46,;5.54,-1.92,;6.88,-1.16,;8.36,-1.55,;8.76,-.07,;10.25,-.46,;10.65,1.02,;9.16,1.42,;7.27,.33,;4.21,-1.16,;2.87,-1.92,;1.54,-1.16,;1.54,.38,;2.87,1.16,;4.21,.38,;.21,1.16,;.21,2.7,;-1.13,3.46,;-2.46,2.7,;-3.79,3.46,;-2.46,1.16,;-1.13,.38,;-3.79,.38,;-3.79,-1.16,;-5.13,1.16,;-6.46,.38,;-6.6,-1.15,;-7.99,-1.8,;-9.25,-.92,;-10.65,-1.57,;-9.12,.62,;-7.72,1.27,)| Show InChI InChI=1S/C25H32N4O3/c1-16(29-12-25(13-29)14-32-15-25)17-2-4-18(5-3-17)19-10-22(23(26)27-11-19)24(31)28-20-6-8-21(30)9-7-20/h2-5,10-11,16,20-21,30H,6-9,12-15H2,1H3,(H2,26,27)(H,28,31)/t16-,20-,21-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	830	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49...				US Patent US10947218 (2021) BindingDB Entry DOI: 10.7270/Q24F1TVV
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A [198-525] (Homo sapiens (Human))	BDBM451807 (US10710980, Example 39 | US10947218, Example 39) Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(C2)C1CCN(CC(F)(F)F)CC1 |r,wU:23.25,10.10,wD:25.27,13.14,(-5.29,7.1,;-3.96,6.33,;-2.63,7.1,;-1.29,6.33,;-1.29,4.79,;-2.63,4.02,;-3.96,4.79,;-5.29,4.02,;-6.63,4.79,;-5.29,2.48,;-6.78,2.08,;-7.18,.6,;-8.67,.2,;-9.76,1.29,;-11.24,.89,;-9.36,2.77,;-7.87,3.17,;.04,4.02,;.04,2.48,;1.38,1.71,;2.71,2.48,;2.71,4.02,;1.38,4.79,;4.04,1.71,;4.2,3.24,;5.45,2.34,;6.48,1.19,;5.71,-.14,;4.2,.18,;6.34,-1.55,;5.43,-2.79,;6.06,-4.2,;7.59,-4.36,;8.22,-5.77,;9.76,-5.77,;10.53,-7.1,;10.53,-4.43,;11.24,-5.37,;8.49,-3.12,;7.87,-1.71,)| Show InChI InChI=1S/C30H38F3N5O2/c31-30(32,33)18-37-11-9-24(10-12-37)38-16-22-14-29(22,17-38)21-3-1-19(2-4-21)20-13-26(27(34)35-15-20)28(40)36-23-5-7-25(39)8-6-23/h1-4,13,15,22-25,39H,5-12,14,16-18H2,(H2,34,35)(H,36,40)/t22-,23-,25-,29+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	830	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49...				US Patent US10947218 (2021) BindingDB Entry DOI: 10.7270/Q24F1TVV
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A [198-525] (Homo sapiens (Human))	BDBM451775 (US10710980, Example 7 | US10947218, Example 7) Show SMILES COCCN1C[C@@H]2C[C@@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)NC12CCC(O)(CC1)CC2 |r| Show InChI InChI=1S/C28H36N4O3/c1-35-13-12-32-17-22-15-28(22,18-32)21-4-2-19(3-5-21)20-14-23(24(29)30-16-20)25(33)31-26-6-9-27(34,10-7-26)11-8-26/h2-5,14,16,22,34H,6-13,15,17-18H2,1H3,(H2,29,30)(H,31,33)/t22-,26?,27?,28+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	875	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were generated by ...				US Patent US10710980 (2020) BindingDB Entry DOI: 10.7270/Q2DF6V81
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A [198-525] (Homo sapiens (Human))	BDBM451775 (US10710980, Example 7 | US10947218, Example 7) Show SMILES COCCN1C[C@@H]2C[C@@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)NC12CCC(O)(CC1)CC2 |r| Show InChI InChI=1S/C28H36N4O3/c1-35-13-12-32-17-22-15-28(22,18-32)21-4-2-19(3-5-21)20-14-23(24(29)30-16-20)25(33)31-26-6-9-27(34,10-7-26)11-8-26/h2-5,14,16,22,34H,6-13,15,17-18H2,1H3,(H2,29,30)(H,31,33)/t22-,26?,27?,28+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	875	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49...				US Patent US10947218 (2021) BindingDB Entry DOI: 10.7270/Q24F1TVV
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A [198-525] (Homo sapiens (Human))	BDBM522143 (US11160797, Example 51) Show SMILES CC(C)n1cc(ccc1=O)-c1cncc(c1)-c1ccc2N(CC3CCC3)S(=O)(=O)Cc2c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	880	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Example 53: The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were g...				Citation and Details BindingDB Entry DOI: 10.7270/Q2M048M3
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A [198-525] (Homo sapiens (Human))	BDBM451803 (US10710980, Example 35 | US10947218, Example 35) Show SMILES Nc1ncc(cc1C(=O)NC12CCC(O)(CC1)CC2)-c1ccc(cc1)[C@]12C[C@H]1CN(C2)C1CCC(F)(F)CC1 |r| Show InChI InChI=1S/C31H38F2N4O2/c32-31(33)7-5-24(6-8-31)37-18-23-16-30(23,19-37)22-3-1-20(2-4-22)21-15-25(26(34)35-17-21)27(38)36-28-9-12-29(39,13-10-28)14-11-28/h1-4,15,17,23-24,39H,5-14,16,18-19H2,(H2,34,35)(H,36,38)/t23-,28?,29?,30+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	903	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49...				US Patent US10947218 (2021) BindingDB Entry DOI: 10.7270/Q24F1TVV
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A [198-525] (Homo sapiens (Human))	BDBM451803 (US10710980, Example 35 | US10947218, Example 35) Show SMILES Nc1ncc(cc1C(=O)NC12CCC(O)(CC1)CC2)-c1ccc(cc1)[C@]12C[C@H]1CN(C2)C1CCC(F)(F)CC1 |r| Show InChI InChI=1S/C31H38F2N4O2/c32-31(33)7-5-24(6-8-31)37-18-23-16-30(23,19-37)22-3-1-20(2-4-22)21-15-25(26(34)35-17-21)27(38)36-28-9-12-29(39,13-10-28)14-11-28/h1-4,15,17,23-24,39H,5-14,16,18-19H2,(H2,34,35)(H,36,38)/t23-,28?,29?,30+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	903	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were generated by ...				US Patent US10710980 (2020) BindingDB Entry DOI: 10.7270/Q2DF6V81
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A [198-525] (Homo sapiens (Human))	BDBM451802 (US10710980, Example 34 | US10947218, Example 34) Show SMILES Nc1ncc(cc1C(=O)NC12CCC(O)(CC1)CC2)-c1ccc(cc1)[C@@]12C[C@@H]1CN(C2)C1CCOCC1 |r| Show InChI InChI=1S/C30H38N4O3/c31-26-25(27(35)33-28-7-10-29(36,11-8-28)12-9-28)15-21(17-32-26)20-1-3-22(4-2-20)30-16-23(30)18-34(19-30)24-5-13-37-14-6-24/h1-4,15,17,23-24,36H,5-14,16,18-19H2,(H2,31,32)(H,33,35)/t23-,28?,29?,30+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	914	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49...				US Patent US10947218 (2021) BindingDB Entry DOI: 10.7270/Q24F1TVV
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A [198-525] (Homo sapiens (Human))	BDBM451802 (US10710980, Example 34 | US10947218, Example 34) Show SMILES Nc1ncc(cc1C(=O)NC12CCC(O)(CC1)CC2)-c1ccc(cc1)[C@@]12C[C@@H]1CN(C2)C1CCOCC1 |r| Show InChI InChI=1S/C30H38N4O3/c31-26-25(27(35)33-28-7-10-29(36,11-8-28)12-9-28)15-21(17-32-26)20-1-3-22(4-2-20)30-16-23(30)18-34(19-30)24-5-13-37-14-6-24/h1-4,15,17,23-24,36H,5-14,16,18-19H2,(H2,31,32)(H,33,35)/t23-,28?,29?,30+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	914	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were generated by ...				US Patent US10710980 (2020) BindingDB Entry DOI: 10.7270/Q2DF6V81
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A [198-525] (Homo sapiens (Human))	BDBM522125 (US11160797, Example 33) Show SMILES CC(C)n1cc(ccc1=O)-c1cncc(c1)-c1ccc2C(C)C(=O)Nc2c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	920	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Example 53: The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were g...				Citation and Details BindingDB Entry DOI: 10.7270/Q2M048M3
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A [198-525] (Homo sapiens (Human))	BDBM451825 (US10710980, Example 54 | US10947218, Example 54) Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(CC#C)C2 |r,wU:23.25,10.10,wD:13.14,25.27,(-4.69,4.29,;-3.36,3.52,;-2.02,4.29,;-.69,3.52,;-.69,1.98,;-2.02,1.21,;-3.36,1.98,;-4.69,1.21,;-6.03,1.98,;-4.69,-.33,;-6.03,-1.1,;-6.16,-2.64,;-7.56,-3.29,;-8.82,-2.4,;-10.04,-3.01,;-8.68,-.87,;-7.29,-.22,;.64,1.21,;.64,-.33,;1.98,-1.1,;3.31,-.33,;3.31,1.21,;1.98,1.98,;4.64,-1.1,;4.8,.43,;6.05,-.48,;7.08,-1.62,;6.31,-2.95,;7.08,-4.29,;8.51,-4.29,;10.04,-4.29,;4.8,-2.63,)| Show InChI InChI=1S/C26H30N4O2/c1-2-11-30-15-20-13-26(20,16-30)19-5-3-17(4-6-19)18-12-23(24(27)28-14-18)25(32)29-21-7-9-22(31)10-8-21/h1,3-6,12,14,20-22,31H,7-11,13,15-16H2,(H2,27,28)(H,29,32)/t20-,21-,22-,26+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	920	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49...				US Patent US10947218 (2021) BindingDB Entry DOI: 10.7270/Q24F1TVV
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A [198-525] (Homo sapiens (Human))	BDBM451825 (US10710980, Example 54 | US10947218, Example 54) Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(CC#C)C2 |r,wU:23.25,10.10,wD:13.14,25.27,(-4.69,4.29,;-3.36,3.52,;-2.02,4.29,;-.69,3.52,;-.69,1.98,;-2.02,1.21,;-3.36,1.98,;-4.69,1.21,;-6.03,1.98,;-4.69,-.33,;-6.03,-1.1,;-6.16,-2.64,;-7.56,-3.29,;-8.82,-2.4,;-10.04,-3.01,;-8.68,-.87,;-7.29,-.22,;.64,1.21,;.64,-.33,;1.98,-1.1,;3.31,-.33,;3.31,1.21,;1.98,1.98,;4.64,-1.1,;4.8,.43,;6.05,-.48,;7.08,-1.62,;6.31,-2.95,;7.08,-4.29,;8.51,-4.29,;10.04,-4.29,;4.8,-2.63,)| Show InChI InChI=1S/C26H30N4O2/c1-2-11-30-15-20-13-26(20,16-30)19-5-3-17(4-6-19)18-12-23(24(27)28-14-18)25(32)29-21-7-9-22(31)10-8-21/h1,3-6,12,14,20-22,31H,7-11,13,15-16H2,(H2,27,28)(H,29,32)/t20-,21-,22-,26+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	920	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were generated by ...				US Patent US10710980 (2020) BindingDB Entry DOI: 10.7270/Q2DF6V81
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A [198-525] (Homo sapiens (Human))	BDBM522142 (US11160797, Example 50) Show SMILES CC(C)CN1c2ccc(cc2CS1(=O)=O)-c1cncc(c1)-c1ccc(=O)n(c1)C(C)C Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	930	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Example 53: The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were g...				Citation and Details BindingDB Entry DOI: 10.7270/Q2M048M3
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A [198-525] (Homo sapiens (Human))	BDBM522138 (US11160797, Example 46) Show SMILES CC(C)n1cc(ccc1=O)-c1cncc(n1)-c1ccc2N(C)C(=O)Cc2c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	930	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Example 53: The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were g...				Citation and Details BindingDB Entry DOI: 10.7270/Q2M048M3
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A [198-525] (Homo sapiens (Human))	BDBM451774 (US10710980, Example 6 | US10947218, Example 6) Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(C2)C(CF)CF |r,wU:23.25,10.10,wD:25.27,13.14,(-4.31,5.66,;-2.97,4.89,;-1.64,5.66,;-.3,4.89,;-.3,3.35,;-1.64,2.58,;-2.97,3.35,;-4.31,2.58,;-5.64,3.35,;-4.31,1.04,;-5.64,.27,;-5.77,-1.27,;-7.17,-1.92,;-8.43,-1.03,;-9.63,-1.68,;-8.3,.5,;-6.9,1.15,;1.03,2.58,;1.03,1.04,;2.36,.27,;3.7,1.04,;3.7,2.58,;2.36,3.35,;5.03,.27,;5.19,1.8,;6.44,.89,;7.47,-.25,;6.7,-1.58,;5.19,-1.26,;7.32,-2.99,;6.55,-4.32,;7.32,-5.66,;8.86,-2.99,;9.63,-4.32,)| Show InChI InChI=1S/C26H32F2N4O2/c27-11-21(12-28)32-14-19-10-26(19,15-32)18-3-1-16(2-4-18)17-9-23(24(29)30-13-17)25(34)31-20-5-7-22(33)8-6-20/h1-4,9,13,19-22,33H,5-8,10-12,14-15H2,(H2,29,30)(H,31,34)/t19-,20-,22-,26+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	940	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were generated by ...				US Patent US10710980 (2020) BindingDB Entry DOI: 10.7270/Q2DF6V81
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A [198-525] (Homo sapiens (Human))	BDBM451774 (US10710980, Example 6 | US10947218, Example 6) Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(C2)C(CF)CF |r,wU:23.25,10.10,wD:25.27,13.14,(-4.31,5.66,;-2.97,4.89,;-1.64,5.66,;-.3,4.89,;-.3,3.35,;-1.64,2.58,;-2.97,3.35,;-4.31,2.58,;-5.64,3.35,;-4.31,1.04,;-5.64,.27,;-5.77,-1.27,;-7.17,-1.92,;-8.43,-1.03,;-9.63,-1.68,;-8.3,.5,;-6.9,1.15,;1.03,2.58,;1.03,1.04,;2.36,.27,;3.7,1.04,;3.7,2.58,;2.36,3.35,;5.03,.27,;5.19,1.8,;6.44,.89,;7.47,-.25,;6.7,-1.58,;5.19,-1.26,;7.32,-2.99,;6.55,-4.32,;7.32,-5.66,;8.86,-2.99,;9.63,-4.32,)| Show InChI InChI=1S/C26H32F2N4O2/c27-11-21(12-28)32-14-19-10-26(19,15-32)18-3-1-16(2-4-18)17-9-23(24(29)30-13-17)25(34)31-20-5-7-22(33)8-6-20/h1-4,9,13,19-22,33H,5-8,10-12,14-15H2,(H2,29,30)(H,31,34)/t19-,20-,22-,26+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	940	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49...				US Patent US10947218 (2021) BindingDB Entry DOI: 10.7270/Q24F1TVV
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A [198-525] (Homo sapiens (Human))	BDBM451805 (US10710980, Example 37 | US10947218, Example 37) Show SMILES CC#CCN1C[C@@H]2C[C@@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:6.6,26.29,wD:8.11,29.33,(11.1,-4.32,;9.56,-4.32,;8.02,-4.32,;6.48,-4.32,;5.85,-2.92,;6.62,-1.58,;5.59,-.44,;4.35,.47,;4.19,-1.07,;4.35,-2.6,;2.85,-.3,;1.52,-1.07,;.18,-.3,;.18,1.24,;1.52,2.01,;2.85,1.24,;-1.15,2.01,;-1.15,3.55,;-2.48,4.32,;-3.82,3.55,;-5.15,4.32,;-3.82,2.01,;-2.48,1.24,;-5.15,1.24,;-6.48,2.01,;-5.15,-.3,;-6.64,-.69,;-7.04,-2.18,;-8.52,-2.58,;-9.61,-1.49,;-11.1,-1.89,;-9.21,-0,;-7.73,.39,)| Show InChI InChI=1S/C27H32N4O2/c1-2-3-12-31-16-21-14-27(21,17-31)20-6-4-18(5-7-20)19-13-24(25(28)29-15-19)26(33)30-22-8-10-23(32)11-9-22/h4-7,13,15,21-23,32H,8-12,14,16-17H2,1H3,(H2,28,29)(H,30,33)/t21-,22-,23-,27+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	960	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49...				US Patent US10947218 (2021) BindingDB Entry DOI: 10.7270/Q24F1TVV
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A [198-525] (Homo sapiens (Human))	BDBM451805 (US10710980, Example 37 | US10947218, Example 37) Show SMILES CC#CCN1C[C@@H]2C[C@@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:6.6,26.29,wD:8.11,29.33,(11.1,-4.32,;9.56,-4.32,;8.02,-4.32,;6.48,-4.32,;5.85,-2.92,;6.62,-1.58,;5.59,-.44,;4.35,.47,;4.19,-1.07,;4.35,-2.6,;2.85,-.3,;1.52,-1.07,;.18,-.3,;.18,1.24,;1.52,2.01,;2.85,1.24,;-1.15,2.01,;-1.15,3.55,;-2.48,4.32,;-3.82,3.55,;-5.15,4.32,;-3.82,2.01,;-2.48,1.24,;-5.15,1.24,;-6.48,2.01,;-5.15,-.3,;-6.64,-.69,;-7.04,-2.18,;-8.52,-2.58,;-9.61,-1.49,;-11.1,-1.89,;-9.21,-0,;-7.73,.39,)| Show InChI InChI=1S/C27H32N4O2/c1-2-3-12-31-16-21-14-27(21,17-31)20-6-4-18(5-7-20)19-13-24(25(28)29-15-19)26(33)30-22-8-10-23(32)11-9-22/h4-7,13,15,21-23,32H,8-12,14,16-17H2,1H3,(H2,28,29)(H,30,33)/t21-,22-,23-,27+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	960	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were generated by ...				US Patent US10710980 (2020) BindingDB Entry DOI: 10.7270/Q2DF6V81
					More data for this Ligand-Target Pair

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