Found 39 hits of ic50 for UniProtKB: P25322 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Cyclin-dependent kinase 6/G1/S-specific cyclin-D1
(Homo sapiens (Human)-Mus musculus (mouse)) | BDBM139540
(US10189849, staurosporine | US10307427, Staurospor...)Show SMILES CN[C@@H]1CC2OC([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r| Show InChI InChI=1S/C27H24N4O3/c1-28-16-11-19-30-17-9-5-4-8-14(17)21-22-15(12-29-26(22)32)20-13-7-3-6-10-18(13)31(23(20)24(21)30)27(34-19)25(16)33-2/h3-10,16,19,25,27-28H,11-12H2,1-2H3,(H,29,32)/t16-,19?,25-,27?/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| | n/a | n/a | 6.18 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1
(Homo sapiens (Human)-Mus musculus (mouse)) | BDBM395789
(US10308654, Example 17)Show SMILES O=C(N1CCC1)c1cc2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n1N1CCCCC1 Show InChI InChI=1S/C24H31N9O/c34-23(31-9-4-10-31)20-15-18-16-27-24(29-22(18)33(20)32-11-2-1-3-12-32)28-21-6-5-19(17-26-21)30-13-7-25-8-14-30/h5-6,15-17,25H,1-4,7-14H2,(H,26,27,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
Human BioMolecular Research Institute
| Assay Description
The test compound was dissolved in dimethyl sulfoxide and the solution was diluted to each concentration gradient with a buffer (50 mM HEPES, 10 mM M... |
J Med Chem 52: 1530-9 (2009)
BindingDB Entry DOI: 10.7270/Q2H70J5J |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1
(Homo sapiens (Human)-Mus musculus (mouse)) | BDBM395801
(US10308654, Example 29)Show SMILES CCN(CC)C(=O)c1cc2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n1N1CCCCC1 Show InChI InChI=1S/C25H35N9O/c1-3-31(4-2)24(35)21-16-19-17-28-25(30-23(19)34(21)33-12-6-5-7-13-33)29-22-9-8-20(18-27-22)32-14-10-26-11-15-32/h8-9,16-18,26H,3-7,10-15H2,1-2H3,(H,27,28,29,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
Human BioMolecular Research Institute
| Assay Description
The test compound was dissolved in dimethyl sulfoxide and the solution was diluted to each concentration gradient with a buffer (50 mM HEPES, 10 mM M... |
J Med Chem 52: 1530-9 (2009)
BindingDB Entry DOI: 10.7270/Q2H70J5J |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1
(Homo sapiens (Human)-Mus musculus (mouse)) | BDBM395784
(US10308654, Example 12)Show SMILES CN(C)C(=O)c1cc2cnc(Nc3ccc(cn3)N3CCN(CC3)C(=O)OC(C)(C)C)nc2n1N1CCCCC1 Show InChI InChI=1S/C28H39N9O3/c1-28(2,3)40-27(39)35-15-13-34(14-16-35)21-9-10-23(29-19-21)31-26-30-18-20-17-22(25(38)33(4)5)37(24(20)32-26)36-11-7-6-8-12-36/h9-10,17-19H,6-8,11-16H2,1-5H3,(H,29,30,31,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
Human BioMolecular Research Institute
| Assay Description
The test compound was dissolved in dimethyl sulfoxide and the solution was diluted to each concentration gradient with a buffer (50 mM HEPES, 10 mM M... |
J Med Chem 52: 1530-9 (2009)
BindingDB Entry DOI: 10.7270/Q2H70J5J |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1
(Homo sapiens (Human)-Mus musculus (mouse)) | BDBM395785
(US10308654, Example 13)Show SMILES CN(C)C(=O)c1cc2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n1N1CCCCC1 Show InChI InChI=1S/C23H31N9O/c1-29(2)22(33)19-14-17-15-26-23(28-21(17)32(19)31-10-4-3-5-11-31)27-20-7-6-18(16-25-20)30-12-8-24-9-13-30/h6-7,14-16,24H,3-5,8-13H2,1-2H3,(H,25,26,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
Human BioMolecular Research Institute
| Assay Description
The test compound was dissolved in dimethyl sulfoxide and the solution was diluted to each concentration gradient with a buffer (50 mM HEPES, 10 mM M... |
J Med Chem 52: 1530-9 (2009)
BindingDB Entry DOI: 10.7270/Q2H70J5J |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1
(Homo sapiens (Human)-Mus musculus (mouse)) | BDBM395786
(US10308654, Example 14)Show SMILES CN(C)C(=O)c1cc2cnc(Nc3ccc(cn3)N3CCN(C)CC3)nc2n1N1CCCCC1 Show InChI InChI=1S/C24H33N9O/c1-29(2)23(34)20-15-18-16-26-24(28-22(18)33(20)32-9-5-4-6-10-32)27-21-8-7-19(17-25-21)31-13-11-30(3)12-14-31/h7-8,15-17H,4-6,9-14H2,1-3H3,(H,25,26,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
Human BioMolecular Research Institute
| Assay Description
The test compound was dissolved in dimethyl sulfoxide and the solution was diluted to each concentration gradient with a buffer (50 mM HEPES, 10 mM M... |
J Med Chem 52: 1530-9 (2009)
BindingDB Entry DOI: 10.7270/Q2H70J5J |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1
(Homo sapiens (Human)-Mus musculus (mouse)) | BDBM395787
(US10308654, Example 15)Show SMILES CN(C)C(=O)c1cc2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n1N1CCCCCC1 Show InChI InChI=1S/C24H33N9O/c1-30(2)23(34)20-15-18-16-27-24(29-22(18)33(20)32-11-5-3-4-6-12-32)28-21-8-7-19(17-26-21)31-13-9-25-10-14-31/h7-8,15-17,25H,3-6,9-14H2,1-2H3,(H,26,27,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
Human BioMolecular Research Institute
| Assay Description
The test compound was dissolved in dimethyl sulfoxide and the solution was diluted to each concentration gradient with a buffer (50 mM HEPES, 10 mM M... |
J Med Chem 52: 1530-9 (2009)
BindingDB Entry DOI: 10.7270/Q2H70J5J |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1
(Homo sapiens (Human)-Mus musculus (mouse)) | BDBM395788
(US10308654, Example 16)Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3cc(C(=O)N4CCC4)n(N4CCCCC4)c3n2)nc1 Show InChI InChI=1S/C25H33N9O/c1-30-12-14-31(15-13-30)20-6-7-22(26-18-20)28-25-27-17-19-16-21(24(35)32-8-5-9-32)34(23(19)29-25)33-10-3-2-4-11-33/h6-7,16-18H,2-5,8-15H2,1H3,(H,26,27,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
Human BioMolecular Research Institute
| Assay Description
The test compound was dissolved in dimethyl sulfoxide and the solution was diluted to each concentration gradient with a buffer (50 mM HEPES, 10 mM M... |
J Med Chem 52: 1530-9 (2009)
BindingDB Entry DOI: 10.7270/Q2H70J5J |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1
(Homo sapiens (Human)-Mus musculus (mouse)) | BDBM395798
(US10308654, Example 26)Show SMILES CCN1CCN(CC1)c1ccc(Nc2ncc3cc(C(=O)N(C)C)n(N4CCCCC4)c3n2)nc1 Show InChI InChI=1S/C25H35N9O/c1-4-31-12-14-32(15-13-31)20-8-9-22(26-18-20)28-25-27-17-19-16-21(24(35)30(2)3)34(23(19)29-25)33-10-6-5-7-11-33/h8-9,16-18H,4-7,10-15H2,1-3H3,(H,26,27,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
Human BioMolecular Research Institute
| Assay Description
The test compound was dissolved in dimethyl sulfoxide and the solution was diluted to each concentration gradient with a buffer (50 mM HEPES, 10 mM M... |
J Med Chem 52: 1530-9 (2009)
BindingDB Entry DOI: 10.7270/Q2H70J5J |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1
(Homo sapiens (Human)-Mus musculus (mouse)) | BDBM395790
(US10308654, Example 18)Show SMILES CNC(=O)c1cc2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n1N1CCCCC1 Show InChI InChI=1S/C22H29N9O/c1-23-21(32)18-13-16-14-26-22(28-20(16)31(18)30-9-3-2-4-10-30)27-19-6-5-17(15-25-19)29-11-7-24-8-12-29/h5-6,13-15,24H,2-4,7-12H2,1H3,(H,23,32)(H,25,26,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
Human BioMolecular Research Institute
| Assay Description
The test compound was dissolved in dimethyl sulfoxide and the solution was diluted to each concentration gradient with a buffer (50 mM HEPES, 10 mM M... |
J Med Chem 52: 1530-9 (2009)
BindingDB Entry DOI: 10.7270/Q2H70J5J |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1
(Homo sapiens (Human)-Mus musculus (mouse)) | BDBM395791
(US10308654, Example 19)Show SMILES CN(C)C(=O)c1cc2cnc(Nc3ccc(cn3)N3CCN(CC3)C(=O)OC(C)(C)C)nc2n1N1CCCC1 Show InChI InChI=1S/C27H37N9O3/c1-27(2,3)39-26(38)34-14-12-33(13-15-34)20-8-9-22(28-18-20)30-25-29-17-19-16-21(24(37)32(4)5)36(23(19)31-25)35-10-6-7-11-35/h8-9,16-18H,6-7,10-15H2,1-5H3,(H,28,29,30,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
Human BioMolecular Research Institute
| Assay Description
The test compound was dissolved in dimethyl sulfoxide and the solution was diluted to each concentration gradient with a buffer (50 mM HEPES, 10 mM M... |
J Med Chem 52: 1530-9 (2009)
BindingDB Entry DOI: 10.7270/Q2H70J5J |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1
(Homo sapiens (Human)-Mus musculus (mouse)) | BDBM395792
(US10308654, Example 20)Show SMILES CN(C)C(=O)c1cc2cnc(Nc3ccc(cn3)N3CCNC(C)(C)C3)nc2n1N1CCCCC1 Show InChI InChI=1S/C25H35N9O/c1-25(2)17-32(13-10-28-25)19-8-9-21(26-16-19)29-24-27-15-18-14-20(23(35)31(3)4)34(22(18)30-24)33-11-6-5-7-12-33/h8-9,14-16,28H,5-7,10-13,17H2,1-4H3,(H,26,27,29,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
Human BioMolecular Research Institute
| Assay Description
The test compound was dissolved in dimethyl sulfoxide and the solution was diluted to each concentration gradient with a buffer (50 mM HEPES, 10 mM M... |
J Med Chem 52: 1530-9 (2009)
BindingDB Entry DOI: 10.7270/Q2H70J5J |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1
(Homo sapiens (Human)-Mus musculus (mouse)) | BDBM395793
(US10308654, Example 21)Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3cc(C(=O)N4CCCC4)n(N4CCCCC4)c3n2)nc1 Show InChI InChI=1S/C26H35N9O/c1-31-13-15-32(16-14-31)21-7-8-23(27-19-21)29-26-28-18-20-17-22(25(36)33-9-5-6-10-33)35(24(20)30-26)34-11-3-2-4-12-34/h7-8,17-19H,2-6,9-16H2,1H3,(H,27,28,29,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
Human BioMolecular Research Institute
| Assay Description
The test compound was dissolved in dimethyl sulfoxide and the solution was diluted to each concentration gradient with a buffer (50 mM HEPES, 10 mM M... |
J Med Chem 52: 1530-9 (2009)
BindingDB Entry DOI: 10.7270/Q2H70J5J |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1
(Homo sapiens (Human)-Mus musculus (mouse)) | BDBM395799
(US10308654, Example 27)Show SMILES C[C@H]1CN(C[C@@H](C)N1)c1ccc(Nc2ncc3cc(C(=O)N(C)C)n(N4CCCCC4)c3n2)nc1 |r| Show InChI InChI=1S/C25H35N9O/c1-17-15-32(16-18(2)28-17)20-8-9-22(26-14-20)29-25-27-13-19-12-21(24(35)31(3)4)34(23(19)30-25)33-10-6-5-7-11-33/h8-9,12-14,17-18,28H,5-7,10-11,15-16H2,1-4H3,(H,26,27,29,30)/t17-,18+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
Human BioMolecular Research Institute
| Assay Description
The test compound was dissolved in dimethyl sulfoxide and the solution was diluted to each concentration gradient with a buffer (50 mM HEPES, 10 mM M... |
J Med Chem 52: 1530-9 (2009)
BindingDB Entry DOI: 10.7270/Q2H70J5J |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1
(Homo sapiens (Human)-Mus musculus (mouse)) | BDBM395795
(US10308654, Example 23)Show SMILES O=C(N1CCCC1)c1cc2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n1N1CCCCC1 Show InChI InChI=1S/C25H33N9O/c35-24(32-10-4-5-11-32)21-16-19-17-28-25(30-23(19)34(21)33-12-2-1-3-13-33)29-22-7-6-20(18-27-22)31-14-8-26-9-15-31/h6-7,16-18,26H,1-5,8-15H2,(H,27,28,29,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
Human BioMolecular Research Institute
| Assay Description
The test compound was dissolved in dimethyl sulfoxide and the solution was diluted to each concentration gradient with a buffer (50 mM HEPES, 10 mM M... |
J Med Chem 52: 1530-9 (2009)
BindingDB Entry DOI: 10.7270/Q2H70J5J |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1
(Homo sapiens (Human)-Mus musculus (mouse)) | BDBM395796
(US10308654, Example 24)Show SMILES CN(C)C(=O)c1cc2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n1N1CCCC1 Show InChI InChI=1S/C22H29N9O/c1-28(2)21(32)18-13-16-14-25-22(27-20(16)31(18)30-9-3-4-10-30)26-19-6-5-17(15-24-19)29-11-7-23-8-12-29/h5-6,13-15,23H,3-4,7-12H2,1-2H3,(H,24,25,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
Human BioMolecular Research Institute
| Assay Description
The test compound was dissolved in dimethyl sulfoxide and the solution was diluted to each concentration gradient with a buffer (50 mM HEPES, 10 mM M... |
J Med Chem 52: 1530-9 (2009)
BindingDB Entry DOI: 10.7270/Q2H70J5J |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1
(Homo sapiens (Human)-Mus musculus (mouse)) | BDBM395797
(US10308654, Example 25)Show SMILES CN(C)C(=O)c1cc2cnc(Nc3ccc(cn3)N3CCOCC3)nc2n1N1CCCCC1 Show InChI InChI=1S/C23H30N8O2/c1-28(2)22(32)19-14-17-15-25-23(27-21(17)31(19)30-8-4-3-5-9-30)26-20-7-6-18(16-24-20)29-10-12-33-13-11-29/h6-7,14-16H,3-5,8-13H2,1-2H3,(H,24,25,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
Human BioMolecular Research Institute
| Assay Description
The test compound was dissolved in dimethyl sulfoxide and the solution was diluted to each concentration gradient with a buffer (50 mM HEPES, 10 mM M... |
J Med Chem 52: 1530-9 (2009)
BindingDB Entry DOI: 10.7270/Q2H70J5J |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 6/G1/S-specific cyclin-D1
(Homo sapiens (Human)-Mus musculus (mouse)) | BDBM622513
(US20230312583, Compound I-9)Show SMILES CCOc1cc(Nc2ncc3ccc4ncn(C(C)C)c4c3n2)ncc1N1CC2CC(C1)N2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 22.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 6/G1/S-specific cyclin-D1
(Homo sapiens (Human)-Mus musculus (mouse)) | BDBM622518
(US20230312583, Compound I-14)Show SMILES CC(C)n1cnc2ccc3cnc(Nc4cc(Oc5ccccc5)c(cn4)N4CCNCC4)nc3c12 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 23.9 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 6/G1/S-specific cyclin-D1
(Homo sapiens (Human)-Mus musculus (mouse)) | BDBM622506
(US20230312583, Compound I-2)Show SMILES CCN1CCN(CC1)c1cnc(Nc2ncc3ccc4ncn(C(C)C)c4c3n2)cc1OC | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 30.9 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1
(Homo sapiens (Human)-Mus musculus (mouse)) | BDBM395800
(US10308654, Example 28)Show SMILES CN(C)C(=O)c1cc2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n1N1CCOCC1 Show InChI InChI=1S/C22H29N9O2/c1-28(2)21(32)18-13-16-14-25-22(27-20(16)31(18)30-9-11-33-12-10-30)26-19-4-3-17(15-24-19)29-7-5-23-6-8-29/h3-4,13-15,23H,5-12H2,1-2H3,(H,24,25,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Human BioMolecular Research Institute
| Assay Description
The test compound was dissolved in dimethyl sulfoxide and the solution was diluted to each concentration gradient with a buffer (50 mM HEPES, 10 mM M... |
J Med Chem 52: 1530-9 (2009)
BindingDB Entry DOI: 10.7270/Q2H70J5J |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1
(Homo sapiens (Human)-Mus musculus (mouse)) | BDBM395794
(US10308654, Example 22)Show SMILES CN(C)C(=O)c1cc2cnc(Nc3ccc(cn3)N3CCN(C)CC3)nc2n1N1CCOCC1 Show InChI InChI=1S/C23H31N9O2/c1-28(2)22(33)19-14-17-15-25-23(27-21(17)32(19)31-10-12-34-13-11-31)26-20-5-4-18(16-24-20)30-8-6-29(3)7-9-30/h4-5,14-16H,6-13H2,1-3H3,(H,24,25,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Human BioMolecular Research Institute
| Assay Description
The test compound was dissolved in dimethyl sulfoxide and the solution was diluted to each concentration gradient with a buffer (50 mM HEPES, 10 mM M... |
J Med Chem 52: 1530-9 (2009)
BindingDB Entry DOI: 10.7270/Q2H70J5J |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 6/G1/S-specific cyclin-D1
(Homo sapiens (Human)-Mus musculus (mouse)) | BDBM622505
(US20230312583, Compound I-1)Show SMILES COc1cc(Nc2ncc3ccc4ncn(C(C)C)c4c3n2)ncc1N1CCN(C)CC1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 61.8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 6/G1/S-specific cyclin-D1
(Homo sapiens (Human)-Mus musculus (mouse)) | BDBM622516
(US20230312583, Compound I-12)Show SMILES COc1cc(Nc2ncc3ccc4ncn(C(C)C)c4c3n2)ncc1N1CC2CCC1CN2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 67 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 6/G1/S-specific cyclin-D1
(Homo sapiens (Human)-Mus musculus (mouse)) | BDBM622517
(US20230312583, Compound I-13)Show SMILES CC#CCOc1cc(Nc2ncc3ccc4ncn(C(C)C)c4c3n2)ncc1N1CCNCC1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 104 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1
(Mus musculus (mouse)) | BDBM6866
(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b ...)Show SMILES Nc1nc(Nc2ccc(cc2)S(N)(=O)=O)nn1C(=O)c1c(F)cccc1F Show InChI InChI=1S/C15H12F2N6O3S/c16-10-2-1-3-11(17)12(10)13(24)23-14(18)21-15(22-23)20-8-4-6-9(7-5-8)27(19,25)26/h1-7H,(H2,19,25,26)(H3,18,20,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical
| Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 10 uM ATP/[gamma-33P]ATP in a streptavidin coated... |
J Med Chem 48: 4208-11 (2005)
Article DOI: 10.1021/jm050267e
BindingDB Entry DOI: 10.7270/Q22F7KNX |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 6/G1/S-specific cyclin-D1
(Homo sapiens (Human)-Mus musculus (mouse)) | BDBM622515
(US20230312583, Compound I-11)Show SMILES COc1cc(Nc2ncc3ccc4ncn(C(C)C)c4c3n2)ncc1N1C2CCC1CNC2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 116 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1
(Mus musculus (mouse)) | BDBM6870
(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3f ...)Show SMILES Cc1ccsc1C(=O)n1nc(Nc2ccc(cc2)S(N)(=O)=O)nc1N Show InChI InChI=1S/C14H14N6O3S2/c1-8-6-7-24-11(8)12(21)20-13(15)18-14(19-20)17-9-2-4-10(5-3-9)25(16,22)23/h2-7H,1H3,(H2,16,22,23)(H3,15,17,18,19) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical
| Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 10 uM ATP/[gamma-33P]ATP in a streptavidin coated... |
J Med Chem 48: 4208-11 (2005)
Article DOI: 10.1021/jm050267e
BindingDB Entry DOI: 10.7270/Q22F7KNX |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 6/G1/S-specific cyclin-D1
(Homo sapiens (Human)-Mus musculus (mouse)) | BDBM622508
(US20230312583, Compound I-4)Show SMILES COc1cc(Nc2ncc3ccc4ncn(C(C)C)c4c3n2)ncc1N1CC2(CNC2)C1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 123 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 6/G1/S-specific cyclin-D1
(Homo sapiens (Human)-Mus musculus (mouse)) | BDBM622511
(US20230312583, Compound I-7)Show SMILES CCOc1cc(Nc2ncc3ccc4ncn(C(C)C)c4c3n2)ncc1N1CCN(C)CC1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 189 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1
(Mus musculus (mouse)) | BDBM6867
(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3c ...)Show SMILES Cc1ccc(F)c(C(=O)n2nc(Nc3ccc(cc3)S(N)(=O)=O)nc2N)c1F Show InChI InChI=1S/C16H14F2N6O3S/c1-8-2-7-11(17)12(13(8)18)14(25)24-15(19)22-16(23-24)21-9-3-5-10(6-4-9)28(20,26)27/h2-7H,1H3,(H2,20,26,27)(H3,19,21,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical
| Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 10 uM ATP/[gamma-33P]ATP in a streptavidin coated... |
J Med Chem 48: 4208-11 (2005)
Article DOI: 10.1021/jm050267e
BindingDB Entry DOI: 10.7270/Q22F7KNX |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 6/G1/S-specific cyclin-D1
(Homo sapiens (Human)-Mus musculus (mouse)) | BDBM622509
(US20230312583, Compound I-5)Show SMILES COc1cc(Nc2ncc3ccc4ncn(C(C)C)c4c3n2)ncc1N1CCNC(C)(C)C1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 214 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 6/G1/S-specific cyclin-D1
(Homo sapiens (Human)-Mus musculus (mouse)) | BDBM622510
(US20230312583, Compound I-6)Show SMILES CNC1CN(C1)c1cnc(Nc2ncc3ccc4ncn(C(C)C)c4c3n2)cc1OC | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 293 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 6/G1/S-specific cyclin-D1
(Homo sapiens (Human)-Mus musculus (mouse)) | BDBM622523
(US20230312583, Compound V-1)Show SMILES CCOc1cc(Nc2ncc3ccc4ncn(CC)c4c3n2)ncc1N1CCN(CC)CC1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 298 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 6/G1/S-specific cyclin-D1
(Homo sapiens (Human)-Mus musculus (mouse)) | BDBM622519
(US20230312583, Compound I-15)Show SMILES COc1cc(Nc2ncc3ccc4ncn(C(C)C)c4c3n2)ncc1NCC1COC(=O)N1C | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 330 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 6/G1/S-specific cyclin-D1
(Homo sapiens (Human)-Mus musculus (mouse)) | BDBM622507
(US20230312583, Compound I-3)Show SMILES COc1cc(Nc2ncc3ccc4ncn(C(C)C)c4c3n2)ncc1N1CC2(COC2)C1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 344 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 6/G1/S-specific cyclin-D1
(Homo sapiens (Human)-Mus musculus (mouse)) | BDBM622524
(US20230312583, Compound VI-1)Show SMILES COc1cc(Nc2ncc3ccc4nc(C)n(C(C)C)c4c3n2)ncc1N1CCOCC1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 388 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 6/G1/S-specific cyclin-D1
(Homo sapiens (Human)-Mus musculus (mouse)) | BDBM622514
(US20230312583, Compound I-10)Show SMILES CC(C)n1cnc2ccc3cnc(Nc4cc(OCC5CC5)c(cn4)N4CCNCC4)nc3c12 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 435 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 6/G1/S-specific cyclin-D1
(Homo sapiens (Human)-Mus musculus (mouse)) | BDBM622512
(US20230312583, Compound I-8)Show SMILES CCOc1cc(Nc2ncc3ccc4ncn(C(C)C)c4c3n2)ncc1N1CCOCC1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | >500 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
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