Compile Data Set for Download or QSAR

Found 51 hits of ic50 for UniProtKB: P49448   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glutamate dehydrogenase 2, mitochondrial (Human)	BDBM109087 (US10793535, Cmpd ID 671 | US8604016, 671 | US99382...) Show SMILES FC(F)(F)Oc1cccc(CC(=O)Nc2ccc(CCCCc3nnc(NC(=O)Cc4cccnc4)s3)nn2)c1 Show InChI InChI=1S/C26H24F3N7O3S/c27-26(28,29)39-20-8-3-5-17(13-20)14-22(37)31-21-11-10-19(33-34-21)7-1-2-9-24-35-36-25(40-24)32-23(38)15-18-6-4-12-30-16-18/h3-6,8,10-13,16H,1-2,7,9,14-15H2,(H,31,34,37)(H,32,36,38)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Calithera Biosciences, Inc. US Patent					Assay Description Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...				US Patent US10793535 (2020) BindingDB Entry DOI: 10.7270/Q2FJ2KV5
					More data for this Ligand-Target Pair
Glutamate dehydrogenase 2, mitochondrial (Human)	BDBM109082 (US10793535, Cmpd ID 666 | US8604016, 666 | US99382...) Show SMILES FC(F)Oc1cccc(CC(=O)Nc2ccc(CCCCc3nnc(NC(=O)Cc4ccccc4)s3)nn2)c1 Show InChI InChI=1S/C27H26F2N6O3S/c28-26(29)38-21-11-6-9-19(15-21)17-23(36)30-22-14-13-20(32-33-22)10-4-5-12-25-34-35-27(39-25)31-24(37)16-18-7-2-1-3-8-18/h1-3,6-9,11,13-15,26H,4-5,10,12,16-17H2,(H,30,33,36)(H,31,35,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Calithera Biosciences, Inc. US Patent					Assay Description Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...				US Patent US10793535 (2020) BindingDB Entry DOI: 10.7270/Q2FJ2KV5
					More data for this Ligand-Target Pair
Glutamate dehydrogenase 2, mitochondrial (Human)	BDBM109086 (US10793535, Cmpd ID 727 | US8604016, 670 | US99382...) Show SMILES FC(F)(F)Oc1cccc(CC(=O)Nc2ccc(CCCCc3nnc(NC(=O)Cc4ccccn4)s3)nn2)c1 Show InChI InChI=1S/C26H24F3N7O3S/c27-26(28,29)39-20-9-5-6-17(14-20)15-22(37)31-21-12-11-18(33-34-21)7-1-2-10-24-35-36-25(40-24)32-23(38)16-19-8-3-4-13-30-19/h3-6,8-9,11-14H,1-2,7,10,15-16H2,(H,31,34,37)(H,32,36,38)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Calithera Biosciences, Inc. US Patent					Assay Description Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...				US Patent US10793535 (2020) BindingDB Entry DOI: 10.7270/Q2FJ2KV5
					More data for this Ligand-Target Pair
Glutamate dehydrogenase 2, mitochondrial (Human)	BDBM108867 (US10793535, Cmpd ID 447 | US8604016, 447 | US99382...) Show SMILES OC(C(=O)Nc1nnc(CCCCc2ccc(NC(=O)Cc3cccc(OC(F)(F)F)c3)nn2)s1)c1cccc(Cl)c1 Show InChI InChI=1S/C27H24ClF3N6O4S/c28-18-7-4-6-17(15-18)24(39)25(40)33-26-37-36-23(42-26)10-2-1-8-19-11-12-21(35-34-19)32-22(38)14-16-5-3-9-20(13-16)41-27(29,30)31/h3-7,9,11-13,15,24,39H,1-2,8,10,14H2,(H,32,35,38)(H,33,37,40)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Calithera Biosciences, Inc. US Patent					Assay Description Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...				US Patent US10793535 (2020) BindingDB Entry DOI: 10.7270/Q2FJ2KV5
					More data for this Ligand-Target Pair
Glutamate dehydrogenase 2, mitochondrial (Human)	BDBM109074 (US10793535, Cmpd ID 658 | US8604016, 658 | US99382...) Show SMILES COc1cccc(CC(=O)Nc2nnc(CCCCc3ccc(NC(=O)Cc4cccc(OC(F)(F)F)c4)nn3)s2)c1 Show InChI InChI=1S/C28H27F3N6O4S/c1-40-21-9-4-6-18(14-21)17-25(39)33-27-37-36-26(42-27)11-3-2-8-20-12-13-23(35-34-20)32-24(38)16-19-7-5-10-22(15-19)41-28(29,30)31/h4-7,9-10,12-15H,2-3,8,11,16-17H2,1H3,(H,32,35,38)(H,33,37,39)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Calithera Biosciences, Inc. US Patent					Assay Description Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...				US Patent US10793535 (2020) BindingDB Entry DOI: 10.7270/Q2FJ2KV5
					More data for this Ligand-Target Pair
Glutamate dehydrogenase 2, mitochondrial (Human)	BDBM109018 (US10793535, Cmpd ID 600 | US8604016, 600 | US99382...) Show SMILES CCOC(=O)NCc1cccc(CC(=O)Nc2nnc(CCCCc3ccc(NC(=O)Cc4cccc(OC(F)(F)F)c4)nn3)s2)c1 Show InChI InChI=1S/C31H32F3N7O5S/c1-2-45-30(44)35-19-22-9-5-7-20(15-22)17-27(43)37-29-41-40-28(47-29)12-4-3-10-23-13-14-25(39-38-23)36-26(42)18-21-8-6-11-24(16-21)46-31(32,33)34/h5-9,11,13-16H,2-4,10,12,17-19H2,1H3,(H,35,44)(H,36,39,42)(H,37,41,43)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Calithera Biosciences, Inc. US Patent					Assay Description Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...				US Patent US10793535 (2020) BindingDB Entry DOI: 10.7270/Q2FJ2KV5
					More data for this Ligand-Target Pair
Glutamate dehydrogenase 2, mitochondrial (Human)	BDBM108759 (US10793535, Cmpd ID 339 | US8604016, 339 | US99382...) Show SMILES CC(C)(C)OC(=O)NCc1cccc(CC(=O)Nc2nnc(CCCCc3ccc(NC(=O)Cc4ccccc4)nn3)s2)c1 Show InChI InChI=1S/C32H37N7O4S/c1-32(2,3)43-31(42)33-21-24-13-9-12-23(18-24)20-28(41)35-30-39-38-29(44-30)15-8-7-14-25-16-17-26(37-36-25)34-27(40)19-22-10-5-4-6-11-22/h4-6,9-13,16-18H,7-8,14-15,19-21H2,1-3H3,(H,33,42)(H,34,37,40)(H,35,39,41)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Calithera Biosciences, Inc. US Patent					Assay Description Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...				US Patent US10793535 (2020) BindingDB Entry DOI: 10.7270/Q2FJ2KV5
					More data for this Ligand-Target Pair
Glutamate dehydrogenase 2, mitochondrial (Human)	BDBM108856 (US10793535, Cmpd ID 436 | US8604016, 436 | US99382...) Show SMILES CC(C(=O)Nc1ccc(CCCCc2nnc(NC(=O)Cc3cccc(CNC(=O)OC(C)(C)C)c3)s2)nn1)c1ccccc1 Show InChI InChI=1S/C33H39N7O4S/c1-22(25-13-6-5-7-14-25)30(42)35-27-18-17-26(37-38-27)15-8-9-16-29-39-40-31(45-29)36-28(41)20-23-11-10-12-24(19-23)21-34-32(43)44-33(2,3)4/h5-7,10-14,17-19,22H,8-9,15-16,20-21H2,1-4H3,(H,34,43)(H,35,38,42)(H,36,40,41)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Calithera Biosciences, Inc. US Patent					Assay Description Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...				US Patent US10793535 (2020) BindingDB Entry DOI: 10.7270/Q2FJ2KV5
					More data for this Ligand-Target Pair
Glutamate dehydrogenase 2, mitochondrial (Human)	BDBM108739 (US10793535, Cmpd ID 318 | US8604016, 318 | US99382...) Show SMILES OC(C(=O)Nc1nnc(CCCCc2ccc(NC(=O)Cc3ccccc3)nn2)s1)c1cccc(Cl)c1 Show InChI InChI=1S/C26H25ClN6O3S/c27-19-10-6-9-18(16-19)24(35)25(36)29-26-33-32-23(37-26)12-5-4-11-20-13-14-21(31-30-20)28-22(34)15-17-7-2-1-3-8-17/h1-3,6-10,13-14,16,24,35H,4-5,11-12,15H2,(H,28,31,34)(H,29,33,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Calithera Biosciences, Inc. US Patent					Assay Description Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...				US Patent US10793535 (2020) BindingDB Entry DOI: 10.7270/Q2FJ2KV5
					More data for this Ligand-Target Pair
Glutamate dehydrogenase 2, mitochondrial (Human)	BDBM109003 (US10793535, Cmpd ID 585 | US8604016, 585 | US99382...) Show SMILES FC(F)(F)Oc1cccc(CC(=O)Nc2ccc(CCCCc3nnc(NC(=O)Cc4ccccc4)s3)nn2)c1 Show InChI InChI=1S/C27H25F3N6O3S/c28-27(29,30)39-21-11-6-9-19(15-21)17-23(37)31-22-14-13-20(33-34-22)10-4-5-12-25-35-36-26(40-25)32-24(38)16-18-7-2-1-3-8-18/h1-3,6-9,11,13-15H,4-5,10,12,16-17H2,(H,31,34,37)(H,32,36,38)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Calithera Biosciences, Inc. US Patent					Assay Description Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...				US Patent US10793535 (2020) BindingDB Entry DOI: 10.7270/Q2FJ2KV5
					More data for this Ligand-Target Pair
Glutamate dehydrogenase 2, mitochondrial (Human)	BDBM109089 (US10793535, Cmpd ID 673 | US8604016, 673 | US99382...) Show SMILES Fc1ccccc1CC(=O)Nc1nnc(CCCCc2ccc(NC(=O)Cc3cccc(OC(F)(F)F)c3)nn2)s1 Show InChI InChI=1S/C27H24F4N6O3S/c28-21-10-3-1-7-18(21)16-24(39)33-26-37-36-25(41-26)11-4-2-8-19-12-13-22(35-34-19)32-23(38)15-17-6-5-9-20(14-17)40-27(29,30)31/h1,3,5-7,9-10,12-14H,2,4,8,11,15-16H2,(H,32,35,38)(H,33,37,39)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Calithera Biosciences, Inc. US Patent					Assay Description Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...				US Patent US10793535 (2020) BindingDB Entry DOI: 10.7270/Q2FJ2KV5
					More data for this Ligand-Target Pair
Glutamate dehydrogenase 2, mitochondrial (Human)	BDBM108951 (US10793535, Cmpd ID 533 | US8604016, 533 | US99382...) Show SMILES Fc1ccccc1CC(=O)Nc1nnc(CCCCc2ccc(NC(=O)Cc3ccccc3Cl)nn2)s1 Show InChI InChI=1S/C26H24ClFN6O2S/c27-20-10-4-1-7-17(20)15-23(35)29-22-14-13-19(31-32-22)9-3-6-12-25-33-34-26(37-25)30-24(36)16-18-8-2-5-11-21(18)28/h1-2,4-5,7-8,10-11,13-14H,3,6,9,12,15-16H2,(H,29,32,35)(H,30,34,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Calithera Biosciences, Inc. US Patent					Assay Description Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...				US Patent US10793535 (2020) BindingDB Entry DOI: 10.7270/Q2FJ2KV5
					More data for this Ligand-Target Pair
Glutamate dehydrogenase 2, mitochondrial (Human)	BDBM109077 (US10793535, Cmpd ID 661 | US8604016, 661 | US99382...) Show SMILES Fc1ccc(CC(=O)Nc2nnc(CCCCc3ccc(NC(=O)Cc4cccc(OC(F)(F)F)c4)nn3)s2)cc1 Show InChI InChI=1S/C27H24F4N6O3S/c28-19-10-8-17(9-11-19)15-24(39)33-26-37-36-25(41-26)7-2-1-5-20-12-13-22(35-34-20)32-23(38)16-18-4-3-6-21(14-18)40-27(29,30)31/h3-4,6,8-14H,1-2,5,7,15-16H2,(H,32,35,38)(H,33,37,39)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Calithera Biosciences, Inc. US Patent					Assay Description Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...				US Patent US10793535 (2020) BindingDB Entry DOI: 10.7270/Q2FJ2KV5
					More data for this Ligand-Target Pair
Glutamate dehydrogenase 2, mitochondrial (Human)	BDBM109078 (US10793535, Cmpd ID 662 | US8604016, 662 | US99382...) Show SMILES Fc1cc(F)cc(CC(=O)Nc2nnc(CCCCc3ccc(NC(=O)Cc4cccc(OC(F)(F)F)c4)nn3)s2)c1 Show InChI InChI=1S/C27H23F5N6O3S/c28-18-10-17(11-19(29)15-18)14-24(40)34-26-38-37-25(42-26)7-2-1-5-20-8-9-22(36-35-20)33-23(39)13-16-4-3-6-21(12-16)41-27(30,31)32/h3-4,6,8-12,15H,1-2,5,7,13-14H2,(H,33,36,39)(H,34,38,40)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Calithera Biosciences, Inc. US Patent					Assay Description Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...				US Patent US10793535 (2020) BindingDB Entry DOI: 10.7270/Q2FJ2KV5
					More data for this Ligand-Target Pair
Glutamate dehydrogenase 2, mitochondrial (Human)	BDBM109079 (US10793535, Cmpd ID 663 | US8604016, 663 | US99382...) Show SMILES Fc1cccc(CC(=O)Nc2nnc(CCCCc3ccc(NC(=O)Cc4cccc(OC(F)(F)F)c4)nn3)s2)c1F Show InChI InChI=1S/C27H23F5N6O3S/c28-20-9-4-6-17(25(20)29)15-23(40)34-26-38-37-24(42-26)10-2-1-7-18-11-12-21(36-35-18)33-22(39)14-16-5-3-8-19(13-16)41-27(30,31)32/h3-6,8-9,11-13H,1-2,7,10,14-15H2,(H,33,36,39)(H,34,38,40)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Calithera Biosciences, Inc. US Patent					Assay Description Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...				US Patent US10793535 (2020) BindingDB Entry DOI: 10.7270/Q2FJ2KV5
					More data for this Ligand-Target Pair
Glutamate dehydrogenase 2, mitochondrial (Human)	BDBM109054 (US10793535, Cmpd ID 636 | US8604016, 636 | US99382...) Show SMILES CC(C(=O)Nc1nnc(CCCCc2ccc(NC(=O)Cc3cccc(OC(F)(F)F)c3)nn2)s1)c1ccccc1 Show InChI InChI=1S/C28H27F3N6O3S/c1-18(20-9-3-2-4-10-20)26(39)33-27-37-36-25(41-27)13-6-5-11-21-14-15-23(35-34-21)32-24(38)17-19-8-7-12-22(16-19)40-28(29,30)31/h2-4,7-10,12,14-16,18H,5-6,11,13,17H2,1H3,(H,32,35,38)(H,33,37,39)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Calithera Biosciences, Inc. US Patent					Assay Description Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...				US Patent US10793535 (2020) BindingDB Entry DOI: 10.7270/Q2FJ2KV5
					More data for this Ligand-Target Pair
Glutamate dehydrogenase 2, mitochondrial (Human)	BDBM109090 (US10793535, Cmpd ID 674 | US8604016, 674 | US99382...) Show SMILES CSc1cccc(CC(=O)Nc2nnc(CCCCc3ccc(NC(=O)Cc4cccc(OC(F)(F)F)c4)nn3)s2)c1 Show InChI InChI=1S/C28H27F3N6O3S2/c1-41-22-10-5-7-19(15-22)17-25(39)33-27-37-36-26(42-27)11-3-2-8-20-12-13-23(35-34-20)32-24(38)16-18-6-4-9-21(14-18)40-28(29,30)31/h4-7,9-10,12-15H,2-3,8,11,16-17H2,1H3,(H,32,35,38)(H,33,37,39)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Calithera Biosciences, Inc. US Patent					Assay Description Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...				US Patent US10793535 (2020) BindingDB Entry DOI: 10.7270/Q2FJ2KV5
					More data for this Ligand-Target Pair
Glutamate dehydrogenase 2, mitochondrial (Human)	BDBM109034 (US10793535, Cmpd ID 616 | US8604016, 616 | US99382...) Show SMILES CC(C(=O)Nc1nnc(CCCCc2ccc(NC(=O)Cc3ccccc3)nn2)s1)c1ccccc1 Show InChI InChI=1S/C27H28N6O2S/c1-19(21-12-6-3-7-13-21)26(35)29-27-33-32-25(36-27)15-9-8-14-22-16-17-23(31-30-22)28-24(34)18-20-10-4-2-5-11-20/h2-7,10-13,16-17,19H,8-9,14-15,18H2,1H3,(H,28,31,34)(H,29,33,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Calithera Biosciences, Inc. US Patent					Assay Description Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...				US Patent US10793535 (2020) BindingDB Entry DOI: 10.7270/Q2FJ2KV5
					More data for this Ligand-Target Pair
Glutamate dehydrogenase 2, mitochondrial (Human)	BDBM109032 (US10793535, Cmpd ID 614 | US8604016, 614 | US99382...) Show SMILES FC(F)(F)Oc1ccccc1CC(=O)Nc1ccc(CCCCc2nnc(NC(=O)Cc3ccccc3)s2)nn1 Show InChI InChI=1S/C27H25F3N6O3S/c28-27(29,30)39-21-12-6-4-10-19(21)17-24(38)31-22-15-14-20(33-34-22)11-5-7-13-25-35-36-26(40-25)32-23(37)16-18-8-2-1-3-9-18/h1-4,6,8-10,12,14-15H,5,7,11,13,16-17H2,(H,31,34,38)(H,32,36,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Calithera Biosciences, Inc. US Patent					Assay Description Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...				US Patent US10793535 (2020) BindingDB Entry DOI: 10.7270/Q2FJ2KV5
					More data for this Ligand-Target Pair
Glutamate dehydrogenase 2, mitochondrial (Human)	BDBM109084 (US10793535, Cmpd ID 668 | US8604016, 668 | US99382...) Show SMILES FC(F)Oc1cccc(CC(=O)Nc2nnc(CCCCc3ccc(NC(=O)Cc4cccc(OC(F)(F)F)c4)nn3)s2)c1 Show InChI InChI=1S/C28H25F5N6O4S/c29-26(30)42-20-8-3-5-17(13-20)16-24(41)35-27-39-38-25(44-27)10-2-1-7-19-11-12-22(37-36-19)34-23(40)15-18-6-4-9-21(14-18)43-28(31,32)33/h3-6,8-9,11-14,26H,1-2,7,10,15-16H2,(H,34,37,40)(H,35,39,41)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Calithera Biosciences, Inc. US Patent					Assay Description Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...				US Patent US10793535 (2020) BindingDB Entry DOI: 10.7270/Q2FJ2KV5
					More data for this Ligand-Target Pair
Glutamate dehydrogenase 2, mitochondrial (Human)	BDBM109033 (US10793535, Cmpd ID 615 | US8604016, 615 | US99382...) Show SMILES FC(F)(F)Oc1ccc(CC(=O)Nc2ccc(CCCCc3nnc(NC(=O)Cc4ccccc4)s3)nn2)cc1 Show InChI InChI=1S/C27H25F3N6O3S/c28-27(29,30)39-21-13-10-19(11-14-21)17-23(37)31-22-15-12-20(33-34-22)8-4-5-9-25-35-36-26(40-25)32-24(38)16-18-6-2-1-3-7-18/h1-3,6-7,10-15H,4-5,8-9,16-17H2,(H,31,34,37)(H,32,36,38)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Calithera Biosciences, Inc. US Patent					Assay Description Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...				US Patent US10793535 (2020) BindingDB Entry DOI: 10.7270/Q2FJ2KV5
					More data for this Ligand-Target Pair
Glutamate dehydrogenase 2, mitochondrial (Human)	BDBM109088 (US10793535, Cmpd ID 672 | US8604016, 672 | US99382...) Show SMILES FC(F)(F)Oc1cccc(CC(=O)Nc2ccc(CCCCc3nnc(NC(=O)Cc4ccncc4)s3)nn2)c1 Show InChI InChI=1S/C26H24F3N7O3S/c27-26(28,29)39-20-6-3-4-18(14-20)16-22(37)31-21-9-8-19(33-34-21)5-1-2-7-24-35-36-25(40-24)32-23(38)15-17-10-12-30-13-11-17/h3-4,6,8-14H,1-2,5,7,15-16H2,(H,31,34,37)(H,32,36,38)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Calithera Biosciences, Inc. US Patent					Assay Description Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...				US Patent US10793535 (2020) BindingDB Entry DOI: 10.7270/Q2FJ2KV5
					More data for this Ligand-Target Pair
Glutamate dehydrogenase 2, mitochondrial (Human)	BDBM109075 (US10793535, Cmpd ID 659 | US8604016, 659 | US99382...) Show SMILES Fc1ccc(F)c(CC(=O)Nc2nnc(CCCCc3ccc(NC(=O)Cc4cccc(OC(F)(F)F)c4)nn3)s2)c1 Show InChI InChI=1S/C27H23F5N6O3S/c28-18-8-10-21(29)17(14-18)15-24(40)34-26-38-37-25(42-26)7-2-1-5-19-9-11-22(36-35-19)33-23(39)13-16-4-3-6-20(12-16)41-27(30,31)32/h3-4,6,8-12,14H,1-2,5,7,13,15H2,(H,33,36,39)(H,34,38,40)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Calithera Biosciences, Inc. US Patent					Assay Description Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...				US Patent US10793535 (2020) BindingDB Entry DOI: 10.7270/Q2FJ2KV5
					More data for this Ligand-Target Pair
Glutamate dehydrogenase 2, mitochondrial (Human)	BDBM108715 (US10793535, Cmpd ID 295 | US8604016, 295 | US99382...) Show SMILES O=C(Cc1ccccc1)Nc1nnc(CCCCc2ccc(NC(=O)Cc3ccccc3)nn2)s1 Show InChI InChI=1S/C26H26N6O2S/c33-23(17-19-9-3-1-4-10-19)27-22-16-15-21(29-30-22)13-7-8-14-25-31-32-26(35-25)28-24(34)18-20-11-5-2-6-12-20/h1-6,9-12,15-16H,7-8,13-14,17-18H2,(H,27,30,33)(H,28,32,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Calithera Biosciences, Inc. US Patent					Assay Description Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...				US Patent US10793535 (2020) BindingDB Entry DOI: 10.7270/Q2FJ2KV5
					More data for this Ligand-Target Pair
Glutamate dehydrogenase 2, mitochondrial (Human)	BDBM383200 (US10278968, Compound 728 | US10793535, Cmpd ID 728) Show SMILES Cc1cccc(CC(=O)Nc2nnc(CCCCc3ccc(NC(=O)Cc4cccc(OC(F)(F)F)c4)nn3)s2)n1 Show InChI InChI=1S/C27H26F3N7O3S/c1-17-6-4-9-20(31-17)16-24(39)33-26-37-36-25(41-26)11-3-2-8-19-12-13-22(35-34-19)32-23(38)15-18-7-5-10-21(14-18)40-27(28,29)30/h4-7,9-10,12-14H,2-3,8,11,15-16H2,1H3,(H,32,35,38)(H,33,37,39)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Calithera Biosciences, Inc. US Patent					Assay Description Glutaminase reaction buffer was prepared [50 mM Tris-HCl pH 8.8, 150 mM K2HPO4, 0.25 mM EDTA, 0.1 mg/ml BSA (Calbiochem no. 2960), 1 mM DTT, 2 mM NAD...				US Patent US10793535 (2020) BindingDB Entry DOI: 10.7270/Q2FJ2KV5
					More data for this Ligand-Target Pair
Glutamate dehydrogenase 2, mitochondrial (Human)	BDBM383202 (US10278968, Compound 730 | US10793535, Cmpd ID 730) Show SMILES Oc1cc(CC(=O)Nc2ccc(CCCCc3nnc(NC(=O)Cc4ccccn4)s3)nn2)cc(OC(F)(F)F)c1 Show InChI InChI=1S/C26H24F3N7O4S/c27-26(28,29)40-20-12-16(11-19(37)15-20)13-22(38)31-21-9-8-17(33-34-21)5-1-2-7-24-35-36-25(41-24)32-23(39)14-18-6-3-4-10-30-18/h3-4,6,8-12,15,37H,1-2,5,7,13-14H2,(H,31,34,38)(H,32,36,39)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Calithera Biosciences, Inc. US Patent					Assay Description Glutaminase reaction buffer was prepared [50 mM Tris-HCl pH 8.8, 150 mM K2HPO4, 0.25 mM EDTA, 0.1 mg/ml BSA (Calbiochem no. 2960), 1 mM DTT, 2 mM NAD...				US Patent US10793535 (2020) BindingDB Entry DOI: 10.7270/Q2FJ2KV5
					More data for this Ligand-Target Pair
Glutamate dehydrogenase 2, mitochondrial (Human)	BDBM109004 (US10793535, Cmpd ID 586 | US8604016, 586 | US99382...) Show SMILES CC(C)(C)OC(=O)NCc1cccc(CC(=O)Nc2nnc(CCCCc3ccc(NC(=O)Cc4cccc(OC(F)(F)F)c4)nn3)s2)c1 Show InChI InChI=1S/C33H36F3N7O5S/c1-32(2,3)48-31(46)37-20-23-10-6-8-21(16-23)18-28(45)39-30-43-42-29(49-30)13-5-4-11-24-14-15-26(41-40-24)38-27(44)19-22-9-7-12-25(17-22)47-33(34,35)36/h6-10,12,14-17H,4-5,11,13,18-20H2,1-3H3,(H,37,46)(H,38,41,44)(H,39,43,45)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Calithera Biosciences, Inc. US Patent					Assay Description Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...				US Patent US10793535 (2020) BindingDB Entry DOI: 10.7270/Q2FJ2KV5
					More data for this Ligand-Target Pair
Glutamate dehydrogenase 2, mitochondrial (Human)	BDBM383201 (US10278968, Compound 729 | US10793535, Cmpd ID 729) Show SMILES COc1cc(CC(=O)Nc2ccc(CCCCc3nnc(NC(=O)Cc4ccccn4)s3)nn2)cc(OC(F)(F)F)c1 Show InChI InChI=1S/C27H26F3N7O4S/c1-40-20-12-17(13-21(16-20)41-27(28,29)30)14-23(38)32-22-10-9-18(34-35-22)6-2-3-8-25-36-37-26(42-25)33-24(39)15-19-7-4-5-11-31-19/h4-5,7,9-13,16H,2-3,6,8,14-15H2,1H3,(H,32,35,38)(H,33,37,39)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Calithera Biosciences, Inc. US Patent					Assay Description Glutaminase reaction buffer was prepared [50 mM Tris-HCl pH 8.8, 150 mM K2HPO4, 0.25 mM EDTA, 0.1 mg/ml BSA (Calbiochem no. 2960), 1 mM DTT, 2 mM NAD...				US Patent US10793535 (2020) BindingDB Entry DOI: 10.7270/Q2FJ2KV5
					More data for this Ligand-Target Pair
Glutamate dehydrogenase 2, mitochondrial (Human)	BDBM383193 (US10278968, Compound 721 | US10793535, Cmpd ID 721) Show SMILES FC(F)(F)Oc1cc(CC(=O)Nc2ccc(CCCCc3nnc(NC(=O)Cc4ccccn4)s3)nn2)ccc1Cl Show InChI InChI=1S/C26H23ClF3N7O3S/c27-19-10-8-16(13-20(19)40-26(28,29)30)14-22(38)32-21-11-9-17(34-35-21)5-1-2-7-24-36-37-25(41-24)33-23(39)15-18-6-3-4-12-31-18/h3-4,6,8-13H,1-2,5,7,14-15H2,(H,32,35,38)(H,33,37,39)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Calithera Biosciences, Inc. US Patent					Assay Description Glutaminase reaction buffer was prepared [50 mM Tris-HCl pH 8.8, 150 mM K2HPO4, 0.25 mM EDTA, 0.1 mg/ml BSA (Calbiochem no. 2960), 1 mM DTT, 2 mM NAD...				US Patent US10793535 (2020) BindingDB Entry DOI: 10.7270/Q2FJ2KV5
					More data for this Ligand-Target Pair
Glutamate dehydrogenase 2, mitochondrial (Human)	BDBM383192 (US10278968, Compound 720 | US10793535, Cmpd ID 720) Show SMILES Fc1ccc(OC(F)(F)F)cc1CC(=O)Nc1ccc(CCCCc2nnc(NC(=O)Cc3ccccn3)s2)nn1 Show InChI InChI=1S/C26H23F4N7O3S/c27-20-10-9-19(40-26(28,29)30)13-16(20)14-22(38)32-21-11-8-17(34-35-21)5-1-2-7-24-36-37-25(41-24)33-23(39)15-18-6-3-4-12-31-18/h3-4,6,8-13H,1-2,5,7,14-15H2,(H,32,35,38)(H,33,37,39)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Calithera Biosciences, Inc. US Patent					Assay Description Glutaminase reaction buffer was prepared [50 mM Tris-HCl pH 8.8, 150 mM K2HPO4, 0.25 mM EDTA, 0.1 mg/ml BSA (Calbiochem no. 2960), 1 mM DTT, 2 mM NAD...				US Patent US10793535 (2020) BindingDB Entry DOI: 10.7270/Q2FJ2KV5
					More data for this Ligand-Target Pair
Glutamate dehydrogenase 2, mitochondrial (Human)	BDBM109085 (US10793535, Cmpd ID 669 | US8604016, 669) Show SMILES FC(F)(F)COc1cccc(CC(=O)Nc2nnc(CCCCc3ccc(NC(=O)Cc4cccc(OC(F)(F)F)c4)nn3)s2)c1 Show InChI InChI=1S/C29H26F6N6O4S/c30-28(31,32)17-44-21-8-3-5-18(13-21)16-25(43)37-27-41-40-26(46-27)10-2-1-7-20-11-12-23(39-38-20)36-24(42)15-19-6-4-9-22(14-19)45-29(33,34)35/h3-6,8-9,11-14H,1-2,7,10,15-17H2,(H,36,39,42)(H,37,41,43)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Calithera Biosciences, Inc. US Patent					Assay Description Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...				US Patent US10793535 (2020) BindingDB Entry DOI: 10.7270/Q2FJ2KV5
					More data for this Ligand-Target Pair
Glutamate dehydrogenase 2, mitochondrial (Human)	BDBM109086 (US10793535, Cmpd ID 727 | US8604016, 670 | US99382...) Show SMILES FC(F)(F)Oc1cccc(CC(=O)Nc2ccc(CCCCc3nnc(NC(=O)Cc4ccccn4)s3)nn2)c1 Show InChI InChI=1S/C26H24F3N7O3S/c27-26(28,29)39-20-9-5-6-17(14-20)15-22(37)31-21-12-11-18(33-34-21)7-1-2-10-24-35-36-25(40-24)32-23(38)16-19-8-3-4-13-30-19/h3-6,8-9,11-14H,1-2,7,10,15-16H2,(H,31,34,37)(H,32,36,38)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	US Patent	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
Calithera Biosciences, Inc. US Patent					Assay Description Glutaminase reaction buffer was prepared [50 mM Tris-HCl pH 8.8, 150 mM K2HPO4, 0.25 mM EDTA, 0.1 mg/ml BSA (Calbiochem no. 2960), 1 mM DTT, 2 mM NAD...				US Patent US10793535 (2020) BindingDB Entry DOI: 10.7270/Q2FJ2KV5
					More data for this Ligand-Target Pair
Glutamate dehydrogenase 2, mitochondrial (Human)	BDBM383194 (US10278968, Compound 722 | US10793535, Cmpd ID 722) Show SMILES COc1ccc(CC(=O)Nc2ccc(CCCCc3nnc(NC(=O)Cc4ccccn4)s3)nn2)cc1OC(F)(F)F Show InChI InChI=1S/C27H26F3N7O4S/c1-40-20-11-9-17(14-21(20)41-27(28,29)30)15-23(38)32-22-12-10-18(34-35-22)6-2-3-8-25-36-37-26(42-25)33-24(39)16-19-7-4-5-13-31-19/h4-5,7,9-14H,2-3,6,8,15-16H2,1H3,(H,32,35,38)(H,33,37,39)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
Calithera Biosciences, Inc. US Patent					Assay Description Glutaminase reaction buffer was prepared [50 mM Tris-HCl pH 8.8, 150 mM K2HPO4, 0.25 mM EDTA, 0.1 mg/ml BSA (Calbiochem no. 2960), 1 mM DTT, 2 mM NAD...				US Patent US10793535 (2020) BindingDB Entry DOI: 10.7270/Q2FJ2KV5
					More data for this Ligand-Target Pair
Glutamate dehydrogenase 2, mitochondrial (Human)	BDBM109076 (US10793535, Cmpd ID 660 | US8604016, 660 | US99382...) Show SMILES FC(F)(F)Oc1cccc(CC(=O)Nc2nnc(CCCCc3ccc(NC(=O)Cc4cccc(OC(F)(F)F)c4)nn3)s2)c1 Show InChI InChI=1S/C28H24F6N6O4S/c29-27(30,31)43-20-8-3-5-17(13-20)15-23(41)35-22-12-11-19(37-38-22)7-1-2-10-25-39-40-26(45-25)36-24(42)16-18-6-4-9-21(14-18)44-28(32,33)34/h3-6,8-9,11-14H,1-2,7,10,15-16H2,(H,35,38,41)(H,36,40,42)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Calithera Biosciences, Inc. US Patent					Assay Description Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...				US Patent US10793535 (2020) BindingDB Entry DOI: 10.7270/Q2FJ2KV5
					More data for this Ligand-Target Pair
Glutamate dehydrogenase 2, mitochondrial (Human)	BDBM383190 (US10278968, Compound 718 | US10793535, Cmpd ID 718) Show SMILES Oc1ccc(OC(F)(F)F)cc1CC(=O)Nc1ccc(CCCCc2nnc(NC(=O)Cc3ccccn3)s2)nn1 Show InChI InChI=1S/C26H24F3N7O4S/c27-26(28,29)40-19-9-10-20(37)16(13-19)14-22(38)31-21-11-8-17(33-34-21)5-1-2-7-24-35-36-25(41-24)32-23(39)15-18-6-3-4-12-30-18/h3-4,6,8-13,37H,1-2,5,7,14-15H2,(H,31,34,38)(H,32,36,39)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
Calithera Biosciences, Inc. US Patent					Assay Description Glutaminase reaction buffer was prepared [50 mM Tris-HCl pH 8.8, 150 mM K2HPO4, 0.25 mM EDTA, 0.1 mg/ml BSA (Calbiochem no. 2960), 1 mM DTT, 2 mM NAD...				US Patent US10793535 (2020) BindingDB Entry DOI: 10.7270/Q2FJ2KV5
					More data for this Ligand-Target Pair
Glutamate dehydrogenase 2, mitochondrial (Human)	BDBM383191 (US10278968, Compound 719 | US10793535, Cmpd ID 719) Show SMILES Fc1ccc(CC(=O)Nc2ccc(CCCCc3nnc(NC(=O)Cc4ccccn4)s3)nn2)cc1OC(F)(F)F Show InChI InChI=1S/C26H23F4N7O3S/c27-19-10-8-16(13-20(19)40-26(28,29)30)14-22(38)32-21-11-9-17(34-35-21)5-1-2-7-24-36-37-25(41-24)33-23(39)15-18-6-3-4-12-31-18/h3-4,6,8-13H,1-2,5,7,14-15H2,(H,32,35,38)(H,33,37,39)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
Calithera Biosciences, Inc. US Patent					Assay Description Glutaminase reaction buffer was prepared [50 mM Tris-HCl pH 8.8, 150 mM K2HPO4, 0.25 mM EDTA, 0.1 mg/ml BSA (Calbiochem no. 2960), 1 mM DTT, 2 mM NAD...				US Patent US10793535 (2020) BindingDB Entry DOI: 10.7270/Q2FJ2KV5
					More data for this Ligand-Target Pair
Glutamate dehydrogenase 2, mitochondrial (Human)	BDBM383189 (US10278968, Compound 717 | US10793535, Cmpd ID 717) Show SMILES COc1ccc(OC(F)(F)F)cc1CC(=O)Nc1ccc(CCCCc2nnc(NC(=O)Cc3ccccn3)s2)nn1 Show InChI InChI=1S/C27H26F3N7O4S/c1-40-21-11-10-20(41-27(28,29)30)14-17(21)15-23(38)32-22-12-9-18(34-35-22)6-2-3-8-25-36-37-26(42-25)33-24(39)16-19-7-4-5-13-31-19/h4-5,7,9-14H,2-3,6,8,15-16H2,1H3,(H,32,35,38)(H,33,37,39)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
Calithera Biosciences, Inc. US Patent					Assay Description Glutaminase reaction buffer was prepared [50 mM Tris-HCl pH 8.8, 150 mM K2HPO4, 0.25 mM EDTA, 0.1 mg/ml BSA (Calbiochem no. 2960), 1 mM DTT, 2 mM NAD...				US Patent US10793535 (2020) BindingDB Entry DOI: 10.7270/Q2FJ2KV5
					More data for this Ligand-Target Pair
Glutamate dehydrogenase 2, mitochondrial (Human)	BDBM383195 (US10278968, Compound 723 | US10793535, Cmpd ID 723) Show SMILES Oc1ccc(CC(=O)Nc2ccc(CCCCc3nnc(NC(=O)Cc4ccccn4)s3)nn2)cc1OC(F)(F)F Show InChI InChI=1S/C26H24F3N7O4S/c27-26(28,29)40-20-13-16(8-10-19(20)37)14-22(38)31-21-11-9-17(33-34-21)5-1-2-7-24-35-36-25(41-24)32-23(39)15-18-6-3-4-12-30-18/h3-4,6,8-13,37H,1-2,5,7,14-15H2,(H,31,34,38)(H,32,36,39)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
Calithera Biosciences, Inc. US Patent					Assay Description Glutaminase reaction buffer was prepared [50 mM Tris-HCl pH 8.8, 150 mM K2HPO4, 0.25 mM EDTA, 0.1 mg/ml BSA (Calbiochem no. 2960), 1 mM DTT, 2 mM NAD...				US Patent US10793535 (2020) BindingDB Entry DOI: 10.7270/Q2FJ2KV5
					More data for this Ligand-Target Pair
Glutamate dehydrogenase 2, mitochondrial (Human)	BDBM383197 (US10278968, Compound 725 | US10793535, Cmpd ID 725) Show SMILES Nc1cccc(CC(=O)Nc2nnc(CCCCc3ccc(NC(=O)Cc4cccc(OC(F)(F)F)c4)nn3)s2)n1 Show InChI InChI=1S/C26H25F3N8O3S/c27-26(28,29)40-19-8-3-5-16(13-19)14-22(38)32-21-12-11-17(34-35-21)6-1-2-10-24-36-37-25(41-24)33-23(39)15-18-7-4-9-20(30)31-18/h3-5,7-9,11-13H,1-2,6,10,14-15H2,(H2,30,31)(H,32,35,38)(H,33,37,39)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Calithera Biosciences, Inc. US Patent					Assay Description Glutaminase reaction buffer was prepared [50 mM Tris-HCl pH 8.8, 150 mM K2HPO4, 0.25 mM EDTA, 0.1 mg/ml BSA (Calbiochem no. 2960), 1 mM DTT, 2 mM NAD...				US Patent US10793535 (2020) BindingDB Entry DOI: 10.7270/Q2FJ2KV5
					More data for this Ligand-Target Pair
Glutamate dehydrogenase 2, mitochondrial (Human)	BDBM108715 (US10793535, Cmpd ID 295 | US8604016, 295 | US99382...) Show SMILES O=C(Cc1ccccc1)Nc1nnc(CCCCc2ccc(NC(=O)Cc3ccccc3)nn2)s1 Show InChI InChI=1S/C26H26N6O2S/c33-23(17-19-9-3-1-4-10-19)27-22-16-15-21(29-30-22)13-7-8-14-25-31-32-26(35-25)28-24(34)18-20-11-5-2-6-12-20/h1-6,9-12,15-16H,7-8,13-14,17-18H2,(H,27,30,33)(H,28,32,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	57	n/a	n/a	n/a	n/a	n/a	n/a
Calithera Biosciences, Inc. US Patent					Assay Description Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...				US Patent US10793535 (2020) BindingDB Entry DOI: 10.7270/Q2FJ2KV5
					More data for this Ligand-Target Pair
Glutamate dehydrogenase 2, mitochondrial (Human)	BDBM108773 (US10793535, Cmpd ID 354 | US8604016, 354 | US99382...) Show SMILES O=C(Cc1ccccn1)Nc1nnc(CCCCc2ccc(NC(=O)Cc3ccccc3)nn2)s1 Show InChI InChI=1S/C25H25N7O2S/c33-22(16-18-8-2-1-3-9-18)27-21-14-13-19(29-30-21)10-4-5-12-24-31-32-25(35-24)28-23(34)17-20-11-6-7-15-26-20/h1-3,6-9,11,13-15H,4-5,10,12,16-17H2,(H,27,30,33)(H,28,32,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Calithera Biosciences, Inc. US Patent					Assay Description Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...				US Patent US10793535 (2020) BindingDB Entry DOI: 10.7270/Q2FJ2KV5
					More data for this Ligand-Target Pair
Glutamate dehydrogenase 2, mitochondrial (Human)	BDBM50400050 (CHEMBL2177757 | US10793535, Cmpd ID 1 | US11191732...) Show SMILES O=C(Cc1ccccc1)Nc1nnc(CCSCCc2nnc(NC(=O)Cc3ccccc3)s2)s1 Show InChI InChI=1S/C24H24N6O2S3/c31-19(15-17-7-3-1-4-8-17)25-23-29-27-21(34-23)11-13-33-14-12-22-28-30-24(35-22)26-20(32)16-18-9-5-2-6-10-18/h1-10H,11-16H2,(H,25,29,31)(H,26,30,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Similars	US Patent	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Calithera Biosciences, Inc. US Patent					Assay Description Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...				US Patent US10793535 (2020) BindingDB Entry DOI: 10.7270/Q2FJ2KV5
					More data for this Ligand-Target Pair
Glutamate dehydrogenase 2, mitochondrial (Human)	BDBM383196 (US10278968, Compound 724 | US10793535, Cmpd ID 724) Show SMILES CC(C)(C)OC(=O)Nc1cccc(CC(=O)Nc2nnc(CCCCc3ccc(NC(=O)Cc4cccc(OC(F)(F)F)c4)nn3)s2)n1 Show InChI InChI=1S/C31H33F3N8O5S/c1-30(2,3)47-29(45)37-23-12-7-10-21(35-23)18-26(44)38-28-42-41-27(48-28)13-5-4-9-20-14-15-24(40-39-20)36-25(43)17-19-8-6-11-22(16-19)46-31(32,33)34/h6-8,10-12,14-16H,4-5,9,13,17-18H2,1-3H3,(H,35,37,45)(H,36,40,43)(H,38,42,44)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
Calithera Biosciences, Inc. US Patent					Assay Description Glutaminase reaction buffer was prepared [50 mM Tris-HCl pH 8.8, 150 mM K2HPO4, 0.25 mM EDTA, 0.1 mg/ml BSA (Calbiochem no. 2960), 1 mM DTT, 2 mM NAD...				US Patent US10793535 (2020) BindingDB Entry DOI: 10.7270/Q2FJ2KV5
					More data for this Ligand-Target Pair
Glutamate dehydrogenase 2, mitochondrial (Human)	BDBM108759 (US10793535, Cmpd ID 339 | US8604016, 339 | US99382...) Show SMILES CC(C)(C)OC(=O)NCc1cccc(CC(=O)Nc2nnc(CCCCc3ccc(NC(=O)Cc4ccccc4)nn3)s2)c1 Show InChI InChI=1S/C32H37N7O4S/c1-32(2,3)43-31(42)33-21-24-13-9-12-23(18-24)20-28(41)35-30-39-38-29(44-30)15-8-7-14-25-16-17-26(37-36-25)34-27(40)19-22-10-5-4-6-11-22/h4-6,9-13,16-18H,7-8,14-15,19-21H2,1-3H3,(H,33,42)(H,34,37,40)(H,35,39,41)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
Calithera Biosciences, Inc. US Patent					Assay Description Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...				US Patent US10793535 (2020) BindingDB Entry DOI: 10.7270/Q2FJ2KV5
					More data for this Ligand-Target Pair
Glutamate dehydrogenase 2, mitochondrial (Human)	BDBM108739 (US10793535, Cmpd ID 318 | US8604016, 318 | US99382...) Show SMILES OC(C(=O)Nc1nnc(CCCCc2ccc(NC(=O)Cc3ccccc3)nn2)s1)c1cccc(Cl)c1 Show InChI InChI=1S/C26H25ClN6O3S/c27-19-10-6-9-18(16-19)24(35)25(36)29-26-33-32-23(37-26)12-5-4-11-20-13-14-21(31-30-20)28-22(34)15-17-7-2-1-3-8-17/h1-3,6-10,13-14,16,24,35H,4-5,11-12,15H2,(H,28,31,34)(H,29,33,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
Calithera Biosciences, Inc. US Patent					Assay Description Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...				US Patent US10793535 (2020) BindingDB Entry DOI: 10.7270/Q2FJ2KV5
					More data for this Ligand-Target Pair
Glutamate dehydrogenase 2, mitochondrial (Human)	BDBM383188 (US10278968, Compound 715 | US10793535, Cmpd ID 715) Show SMILES OC(C(=O)Nc1ccc(CCCCc2nnc(NC(=O)Cc3ccccn3)s2)nn1)c1ccccc1 Show InChI InChI=1S/C25H25N7O3S/c33-21(16-19-11-6-7-15-26-19)28-25-32-31-22(36-25)12-5-4-10-18-13-14-20(30-29-18)27-24(35)23(34)17-8-2-1-3-9-17/h1-3,6-9,11,13-15,23,34H,4-5,10,12,16H2,(H,27,30,35)(H,28,32,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
Calithera Biosciences, Inc. US Patent					Assay Description Glutaminase reaction buffer was prepared [50 mM Tris-HCl pH 8.8, 150 mM K2HPO4, 0.25 mM EDTA, 0.1 mg/ml BSA (Calbiochem no. 2960), 1 mM DTT, 2 mM NAD...				US Patent US10793535 (2020) BindingDB Entry DOI: 10.7270/Q2FJ2KV5
					More data for this Ligand-Target Pair
Glutamate dehydrogenase 2, mitochondrial (Human)	BDBM50400050 (CHEMBL2177757 | US10793535, Cmpd ID 1 | US11191732...) Show SMILES O=C(Cc1ccccc1)Nc1nnc(CCSCCc2nnc(NC(=O)Cc3ccccc3)s2)s1 Show InChI InChI=1S/C24H24N6O2S3/c31-19(15-17-7-3-1-4-8-17)25-23-29-27-21(34-23)11-13-33-14-12-22-28-30-24(35-22)26-20(32)16-18-9-5-2-6-10-18/h1-10H,11-16H2,(H,25,29,31)(H,26,30,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Similars	US Patent	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Calithera Biosciences, Inc. US Patent					Assay Description Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...				US Patent US10793535 (2020) BindingDB Entry DOI: 10.7270/Q2FJ2KV5
					More data for this Ligand-Target Pair
Glutamate dehydrogenase 2, mitochondrial (Human)	BDBM109073 (US10793535, Cmpd ID 726 | US8604016, 657 | US99382...) Show SMILES Nc1nnc(CCCCc2ccc(NC(=O)Cc3cccc(OC(F)(F)F)c3)nn2)s1 Show InChI InChI=1S/C19H19F3N6O2S/c20-19(21,22)30-14-6-3-4-12(10-14)11-16(29)24-15-9-8-13(25-26-15)5-1-2-7-17-27-28-18(23)31-17/h3-4,6,8-10H,1-2,5,7,11H2,(H2,23,28)(H,24,26,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	US Patent	n/a	n/a	240	n/a	n/a	n/a	n/a	n/a	n/a
Calithera Biosciences, Inc. US Patent					Assay Description Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...				US Patent US10793535 (2020) BindingDB Entry DOI: 10.7270/Q2FJ2KV5
					More data for this Ligand-Target Pair
Glutamate dehydrogenase 2, mitochondrial (Human)	BDBM109073 (US10793535, Cmpd ID 726 | US8604016, 657 | US99382...) Show SMILES Nc1nnc(CCCCc2ccc(NC(=O)Cc3cccc(OC(F)(F)F)c3)nn2)s1 Show InChI InChI=1S/C19H19F3N6O2S/c20-19(21,22)30-14-6-3-4-12(10-14)11-16(29)24-15-9-8-13(25-26-15)5-1-2-7-17-27-28-18(23)31-17/h3-4,6,8-10H,1-2,5,7,11H2,(H2,23,28)(H,24,26,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	US Patent	n/a	n/a	540	n/a	n/a	n/a	n/a	n/a	n/a
Calithera Biosciences, Inc. US Patent					Assay Description Glutaminase reaction buffer was prepared [50 mM Tris-HCl pH 8.8, 150 mM K2HPO4, 0.25 mM EDTA, 0.1 mg/ml BSA (Calbiochem no. 2960), 1 mM DTT, 2 mM NAD...				US Patent US10793535 (2020) BindingDB Entry DOI: 10.7270/Q2FJ2KV5
					More data for this Ligand-Target Pair
Glutamate dehydrogenase 2, mitochondrial (Human)	BDBM108822 (US10793535, Cmpd ID 402 | US8604016, 402 | US99382...) Show SMILES CCCC(=O)OCN(C(=O)Cc1ccccc1)c1nnc(CCCCc2ccc(NC(=O)Cc3ccccc3)nn2)s1 Show InChI InChI=1S/C31H34N6O4S/c1-2-11-30(40)41-22-37(29(39)21-24-14-7-4-8-15-24)31-36-35-28(42-31)17-10-9-16-25-18-19-26(34-33-25)32-27(38)20-23-12-5-3-6-13-23/h3-8,12-15,18-19H,2,9-11,16-17,20-22H2,1H3,(H,32,34,38)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Calithera Biosciences, Inc. US Patent					Assay Description Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...				US Patent US10793535 (2020) BindingDB Entry DOI: 10.7270/Q2FJ2KV5
					More data for this Ligand-Target Pair

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