Compile Data Set for Download or QSAR

Found 1856 hits of ic50 for UniProtKB: P50613   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM50526793 (CHEMBL4562323) Show SMILES CC(C)c1cnn2c(NCc3ccccc3-n3cccn3)nc(OC3CCCNC3)nc12 Show InChI InChI=1S/C23H28N8O/c1-16(2)19-15-27-31-21(19)28-23(32-18-8-5-10-24-14-18)29-22(31)25-13-17-7-3-4-9-20(17)30-12-6-11-26-30/h3-4,6-7,9,11-12,15-16,18,24H,5,8,10,13-14H2,1-2H3,(H,25,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	0.130	n/a	n/a	n/a	n/a	n/a	n/a
Tianjin University of Science and Technology Curated by ChEMBL					Assay Description Inhibition of CDK7 (unknown origin)				Eur J Med Chem 183: (2019) Article DOI: 10.1016/j.ejmech.2019.111641 BindingDB Entry DOI: 10.7270/Q24X5C86
					More data for this Ligand-Target Pair				3D Structure (crystal)
Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM7533 ((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...) Show SMILES CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1 |r| Show InChI InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	0.460	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.1c02064 BindingDB Entry DOI: 10.7270/Q2SB49QV
					More data for this Ligand-Target Pair
Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM50300690 (1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...) Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(OCCN4CCOCC4)ccc32)no1 Show InChI InChI=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22-18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4-9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	US Patent	n/a	n/a	0.623	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Table 7 For most assays, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phas...				Citation and Details BindingDB Entry DOI: 10.7270/Q2154MW8
					More data for this Ligand-Target Pair
Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM50300690 (1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...) Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(OCCN4CCOCC4)ccc32)no1 Show InChI InChI=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22-18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4-9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	US Patent	n/a	n/a	0.623	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Table 3 and 4: The HotSpot kinase profiling and screening assays were carried out using the method of Anastassiadis et al., Nat. Biotechnol. (2011) V...				Citation and Details BindingDB Entry DOI: 10.7270/Q2154MW8
					More data for this Ligand-Target Pair
Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM139540 (US10189849, staurosporine | US10307427, Staurospor...) Show SMILES CN[C@@H]1CC2OC([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r| Show InChI InChI=1S/C27H24N4O3/c1-28-16-11-19-30-17-9-5-4-8-14(17)21-22-15(12-29-26(22)32)20-13-7-3-6-10-18(13)31(23(20)24(21)30)27(34-19)25(16)33-2/h3-10,16,19,25,27-28H,11-12H2,1-2H3,(H,29,32)/t16-,19?,25-,27?/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.623	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Table 7 For most assays, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phas...				Citation and Details BindingDB Entry DOI: 10.7270/Q2154MW8
					More data for this Ligand-Target Pair
Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM50300690 (1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...) Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(OCCN4CCOCC4)ccc32)no1 Show InChI InChI=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22-18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4-9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	US Patent	n/a	n/a	0.623	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Table 7 For most assays, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phas...				Citation and Details BindingDB Entry DOI: 10.7270/Q2154MW8
					More data for this Ligand-Target Pair
Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM50377170 (CHEMBL256570 | US11254667, Compound I-2 | US115422...) Show SMILES Clc1ccc2ncc(-c3cccc(NC4CCNCC4)n3)n2c1 Show InChI InChI=1S/C17H18ClN5/c18-12-4-5-17-20-10-15(23(17)11-12)14-2-1-3-16(22-14)21-13-6-8-19-9-7-13/h1-5,10-11,13,19H,6-9H2,(H,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.996	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Table 7 For most assays, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phas...				Citation and Details BindingDB Entry DOI: 10.7270/Q2154MW8
					More data for this Ligand-Target Pair
Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM139540 (US10189849, staurosporine | US10307427, Staurospor...) Show SMILES CN[C@@H]1CC2OC([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r| Show InChI InChI=1S/C27H24N4O3/c1-28-16-11-19-30-17-9-5-4-8-14(17)21-22-15(12-29-26(22)32)20-13-7-3-6-10-18(13)31(23(20)24(21)30)27(34-19)25(16)33-2/h3-10,16,19,25,27-28H,11-12H2,1-2H3,(H,29,32)/t16-,19?,25-,27?/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.996	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Table 7 For most assays, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phas...				Citation and Details BindingDB Entry DOI: 10.7270/Q2154MW8
					More data for this Ligand-Target Pair
Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM50377170 (CHEMBL256570 | US11254667, Compound I-2 | US115422...) Show SMILES Clc1ccc2ncc(-c3cccc(NC4CCNCC4)n3)n2c1 Show InChI InChI=1S/C17H18ClN5/c18-12-4-5-17-20-10-15(23(17)11-12)14-2-1-3-16(22-14)21-13-6-8-19-9-7-13/h1-5,10-11,13,19H,6-9H2,(H,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.996	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Table 3 and 4: The HotSpot kinase profiling and screening assays were carried out using the method of Anastassiadis et al., Nat. Biotechnol. (2011) V...				Citation and Details BindingDB Entry DOI: 10.7270/Q2154MW8
					More data for this Ligand-Target Pair
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM50539763 (Adagrasib | Mrtx-849 | Mrtx849) Show SMILES CN1CCC[C@H]1COc1nc2CN(CCc2c(n1)N1CCN([C@@H](CC#N)C1)C(=O)C(F)=C)c1cccc2cccc(Cl)c12 Show InChI InChI=1S/C32H35ClFN7O2/c1-21(34)31(42)41-17-16-40(18-23(41)11-13-35)30-25-12-15-39(28-10-4-7-22-6-3-9-26(33)29(22)28)19-27(25)36-32(37-30)43-20-24-8-5-14-38(24)2/h3-4,6-7,9-10,23-24H,1,5,8,11-12,14-20H2,2H3/t23-,24-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1039/d2md00216g BindingDB Entry DOI: 10.7270/Q2DF6W53
					More data for this Ligand-Target Pair
Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM50553499 (CHEMBL4754493) Show SMILES Cn1ncc(c1CC1CC1)-c1nc(N[C@H]2CC[C@H](N)CC2)ncc1Cl |r,wU:14.15,wD:17.19,(8.24,3.69,;6.99,4.59,;6.99,6.13,;5.53,6.61,;4.62,5.36,;5.53,4.12,;5.05,2.65,;6.08,1.51,;7.54,1.03,;6.4,,;3.08,5.36,;2.31,6.69,;.77,6.69,;,8.03,;.77,9.36,;,10.7,;.77,12.03,;2.31,12.03,;3.08,13.36,;3.08,10.7,;2.31,9.36,;,5.36,;.77,4.03,;2.31,4.03,;3.08,2.69,)| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.1c02064 BindingDB Entry DOI: 10.7270/Q2SB49QV
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM50553499 (CHEMBL4754493) Show SMILES Cn1ncc(c1CC1CC1)-c1nc(N[C@H]2CC[C@H](N)CC2)ncc1Cl |r,wU:14.15,wD:17.19,(8.24,3.69,;6.99,4.59,;6.99,6.13,;5.53,6.61,;4.62,5.36,;5.53,4.12,;5.05,2.65,;6.08,1.51,;7.54,1.03,;6.4,,;3.08,5.36,;2.31,6.69,;.77,6.69,;,8.03,;.77,9.36,;,10.7,;.77,12.03,;2.31,12.03,;3.08,13.36,;3.08,10.7,;2.31,9.36,;,5.36,;.77,4.03,;2.31,4.03,;3.08,2.69,)| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem		n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Ability to displace [3H]glycine from strychnine-insensitive glycine receptor				Citation and Details
					More data for this Ligand-Target Pair
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM530357 (WO2022064009, Compound 136 | WO2022064009, Compoun...) Show SMILES C[C@@H]1Cc2cnc(NCc3ccn(C)n3)nc2CN1C(=O)[C@@H]1CCN(C)C[C@H]1c1cccc(C)c1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	WIPO WO2022064009	n/a	n/a	1.38	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B
					More data for this Ligand-Target Pair
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM530269 (WO2022064009, Compound 13) Show SMILES C[C@H]1CC[C@@H](CC1)Nc1ncc2C[C@@H](C)N(Cc2n1)C(=O)[C@H]1CCN(C)C[C@@H]1c1ccccc1 |r,wU:27.31,13.14,4.7,wD:21.23,1.0,(5.09,-6.89,;3.75,-7.66,;2.42,-6.89,;1.08,-7.66,;1.08,-9.2,;2.42,-9.97,;3.75,-9.2,;-.25,-9.97,;-1.58,-9.2,;-2.92,-9.97,;-4.25,-9.2,;-4.25,-7.66,;-5.58,-6.89,;-5.58,-5.35,;-6.92,-4.58,;-4.25,-4.58,;-2.92,-5.35,;-2.92,-6.89,;-1.58,-7.66,;-4.25,-3.04,;-5.58,-2.27,;-2.92,-2.27,;-1.58,-3.04,;-.25,-2.27,;-.25,-.73,;1.08,.04,;-1.58,.04,;-2.92,-.73,;-4.25,.04,;-4.25,1.58,;-5.58,2.35,;-6.92,1.58,;-6.92,.04,;-5.58,-.73,)| Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	WIPO WO2022064009	n/a	n/a	1.41	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B
					More data for this Ligand-Target Pair
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM530396 (WO2022064009, Compound 173) Show SMILES C[C@@H]1Cc2cnc(NCc3ccccc3)nc2CN1C(=N)[C@H]1CCN(C)C[C@@H]1c1ccccc1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	WIPO WO2022064009	n/a	n/a	1.66	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B
					More data for this Ligand-Target Pair
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM530309 (WO2022064009, Compound 70) Show SMILES C[C@@H]1Cc2cnc(NCc3ccccc3)nc2CN1C(=O)[C@H]1CCN(C)C[C@@H]1c1ccccc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	WIPO WO2022064009	n/a	n/a	1.78	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B
					More data for this Ligand-Target Pair
Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM50193093 (RGB-286638) Show SMILES COCCN1CCN(Cc2ccc(cc2)-c2n[nH]c3-c4cccc(NC(=O)NN5CCOCC5)c4C(=O)c23)CC1 Show InChI InChI=1S/C29H35N7O4/c1-39-16-13-34-9-11-35(12-10-34)19-20-5-7-21(8-6-20)26-25-27(32-31-26)22-3-2-4-23(24(22)28(25)37)30-29(38)33-36-14-17-40-18-15-36/h2-8H,9-19H2,1H3,(H,31,32)(H2,30,33,38)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Inhibition of CDK7/cyclin H (unknown origin)				J Med Chem 59: 8667-8684 (2016) Article DOI: 10.1021/acs.jmedchem.6b00150 BindingDB Entry DOI: 10.7270/Q2G73GP8
					More data for this Ligand-Target Pair
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM530370 (WO2022064009, Compound 180a) Show SMILES C[C@H]1CN([C@H](C)c2nc(NC3CCOCC3)ncc12)C(=O)[C@H]1CCN(C)C[C@@H]1c1ccccc1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	WIPO WO2022064009	n/a	n/a	2.09	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B
					More data for this Ligand-Target Pair
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM530249 (WO2022064009, Compound 5) Show SMILES C[C@@H]1Cc2cnc(N[C@H]3CCN(C)C(=O)C3)nc2CN1C(=O)[C@H]1CCN(C)C[C@@H]1c1ccccc1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	WIPO WO2022064009	n/a	n/a	2.14	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B
					More data for this Ligand-Target Pair
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM530318 (WO2022064009, Compound 82 | WO2022064009, Compound...) Show SMILES C[C@@H]1Cc2cnc(Nc3cnn(C)c3)nc2CN1C(=O)[C@H]1CCN(C)C[C@@H]1c1ccccc1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	WIPO WO2022064009	n/a	n/a	2.14	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B
					More data for this Ligand-Target Pair
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM530318 (WO2022064009, Compound 82 | WO2022064009, Compound...) Show SMILES C[C@@H]1Cc2cnc(Nc3cnn(C)c3)nc2CN1C(=O)[C@H]1CCN(C)C[C@@H]1c1ccccc1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	WIPO WO2022064009	n/a	n/a	2.14	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B
					More data for this Ligand-Target Pair
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM530297 (WO2022064009, Compound 58) Show SMILES CCn1ccc(CNc2ncc3C[C@@H](C)N(Cc3n2)C(=O)[C@H]2CCN(C)C[C@@H]2c2ccccc2)n1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	WIPO WO2022064009	n/a	n/a	2.34	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B
					More data for this Ligand-Target Pair
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM530245 (WO2022064009, Compound 1 | WO2022064009, Compound ...) Show SMILES C[C@@H]1Cc2cnc(NCc3ccn(C)n3)nc2CN1C(=O)[C@H]1CCN(C)C[C@@H]1c1ccccc1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	WIPO WO2022064009	n/a	n/a	2.45	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B
					More data for this Ligand-Target Pair
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM530266 (WO2022064009, Compound 154 | WO2022064009, Compoun...) Show SMILES C[C@@H]1Cc2cnc(NCc3ccccc3)nc2CN1C(=O)[C@H]1CCN(C)C[C@@H]1c1ccccc1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	WIPO WO2022064009	n/a	n/a	2.51	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B
					More data for this Ligand-Target Pair
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM530260 (WO2022064009, Compound 37) Show SMILES CO[C@H]1CC[C@@H](CC1)Nc1ncc2C[C@@H](C)N(Cc2n1)C(=O)[C@H]1CCN(C)C[C@@H]1c1ccccc1 |r,wU:28.32,14.15,5.8,wD:22.24,2.1,(6.42,-7.66,;5.09,-6.89,;3.75,-7.66,;2.42,-6.89,;1.08,-7.66,;1.08,-9.2,;2.42,-9.97,;3.75,-9.2,;-.25,-9.97,;-1.58,-9.2,;-2.92,-9.97,;-4.25,-9.2,;-4.25,-7.66,;-5.58,-6.89,;-5.58,-5.35,;-6.92,-4.58,;-4.25,-4.58,;-2.92,-5.35,;-2.92,-6.89,;-1.58,-7.66,;-4.25,-3.04,;-5.58,-2.27,;-2.92,-2.27,;-1.58,-3.04,;-.25,-2.27,;-.25,-.73,;1.08,.04,;-1.58,.04,;-2.92,-.73,;-4.25,.04,;-4.25,1.58,;-5.58,2.35,;-6.92,1.58,;-6.92,.04,;-5.58,-.73,)| Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	WIPO WO2022064009	n/a	n/a	2.51	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B
					More data for this Ligand-Target Pair
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM530397 (WO2022064009, Compound 174) Show SMILES C[C@H]1Cc2cnc(NCc3ccn(C)n3)nc2CN1C(=O)[C@H]1CCN(C)C[C@@H]1c1ccccc1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	WIPO WO2022064009	n/a	n/a	2.63	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B
					More data for this Ligand-Target Pair
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM530383 (WO2022064009, Compound 160) Show SMILES CC(C)N1CC[C@@H]([C@H](C1)c1cccc(Cl)c1)C(=O)N1Cc2nc(NC3CCOCC3)ncc2C[C@H]1C |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	WIPO WO2022064009	n/a	n/a	2.63	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B
					More data for this Ligand-Target Pair
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM530252 (WO2022064009, Compound 8) Show SMILES C[C@@H]1Cc2cnc(N[C@@H]3CCOC4(CCC4)C3)nc2CN1C(=O)[C@H]1CCN(C)C[C@@H]1c1ccccc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	WIPO WO2022064009	n/a	n/a	2.69	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B
					More data for this Ligand-Target Pair
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM530308 (WO2022064009, Compound 69) Show SMILES C[C@@H]1Cc2cnc(N[C@H]3CC[C@@H](CC3)OC(F)F)nc2CN1C(=O)[C@H]1CCN(C)C[C@@H]1c1ccccc1 |r,wU:30.34,1.0,8.7,wD:24.26,11.14,(-6.92,-4.58,;-5.58,-5.35,;-5.58,-6.89,;-4.25,-7.66,;-4.25,-9.2,;-2.92,-9.97,;-1.58,-9.2,;-.25,-9.97,;1.08,-9.2,;1.08,-7.66,;2.42,-6.89,;3.75,-7.66,;3.75,-9.2,;2.42,-9.97,;5.08,-6.89,;6.42,-7.66,;6.42,-9.2,;7.75,-6.89,;-1.58,-7.66,;-2.92,-6.89,;-2.92,-5.35,;-4.25,-4.58,;-4.25,-3.04,;-5.58,-2.27,;-2.92,-2.27,;-1.58,-3.04,;-.25,-2.27,;-.25,-.73,;1.08,.04,;-1.58,.04,;-2.92,-.73,;-4.25,.04,;-4.25,1.58,;-5.58,2.35,;-6.92,1.58,;-6.92,.04,;-5.58,-.73,)| Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	WIPO WO2022064009	n/a	n/a	2.69	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B
					More data for this Ligand-Target Pair
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM530305 (WO2022064009, Compound 66) Show SMILES CC(C)n1ccc(CNc2ncc3C[C@@H](C)N(Cc3n2)C(=O)[C@H]2CCN(C)C[C@@H]2c2ccccc2)n1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	WIPO WO2022064009	n/a	n/a	2.75	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B
					More data for this Ligand-Target Pair
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM530280 (WO2022064009, Compound 29) Show SMILES C[C@@H]1Cc2cnc(NC3Cc4ccccc4C3)nc2CN1C(=O)[C@H]1CCN(C)C[C@@H]1c1ccccc1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	WIPO WO2022064009	n/a	n/a	2.82	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B
					More data for this Ligand-Target Pair
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM530401 (WO2022064009, Compound 188) Show SMILES C[C@@H]1CN(Cc2nc(NC3CCOCC3)ncc12)C(=O)[C@H]1CCN(C)C[C@@H]1c1ccccc1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	WIPO WO2022064009	n/a	n/a	2.82	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B
					More data for this Ligand-Target Pair
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM530310 (WO2022064009, Compound 71) Show SMILES C[C@@H]1Cc2cnc(N[C@@H](CO)c3ccccc3)nc2CN1C(=O)[C@H]1CCN(C)C[C@@H]1c1ccccc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	WIPO WO2022064009	n/a	n/a	2.88	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B
					More data for this Ligand-Target Pair
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM50363196 (CHEMBL1944698) Show SMILES CN1C\C=C\CCOc2cccc(c2)-c2ccnc(Nc3cccc(C1)c3)n2 |t:3| Show InChI InChI=1S/C23H24N4O/c1-27-13-3-2-4-14-28-21-10-6-8-19(16-21)22-11-12-24-23(26-22)25-20-9-5-7-18(15-20)17-27/h2-3,5-12,15-16H,4,13-14,17H2,1H3,(H,24,25,26)/b3-2+	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Inhibition of recombinant human full length C-terminal His6-tagged CDK7/cyclin H/N-terminal GST-tagged MAT1 expressed in baculovirus infected Sf21 in...				J Med Chem 59: 8667-8684 (2016) Article DOI: 10.1021/acs.jmedchem.6b00150 BindingDB Entry DOI: 10.7270/Q2G73GP8
					More data for this Ligand-Target Pair
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM530335 (WO2022064009, Compound 120 | WO2022064009, Compoun...) Show SMILES C[C@@H]1Cc2cnc(NC3CCOCC3)nc2CN1C(=O)[C@H]1CCN(C)C[C@@H]1c1ccc(F)cc1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	WIPO WO2022064009	n/a	n/a	3.02	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B
					More data for this Ligand-Target Pair
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM530356 (WO2022064009, Compound 134) Show SMILES C[C@@H]1Cc2cnc(NC3CCOCC3)nc2CN1C(=O)[C@H]1CCN(C)C[C@@H]1c1cccc(C)c1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	WIPO WO2022064009	n/a	n/a	3.16	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B
					More data for this Ligand-Target Pair
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM530337 (WO2022064009, Compound 122b) Show SMILES C[C@@H]1Cc2cnc(NC3CCOCC3)nc2CN1C(=O)[C@H]1CCN(C)C[C@@H]1c1ccc(Cl)c(F)c1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	WIPO WO2022064009	n/a	n/a	3.16	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B
					More data for this Ligand-Target Pair
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM530369 (WO2022064009, Compound 150) Show SMILES CCN1CC[C@@H]([C@H](C1)c1cccc(C)c1)C(=O)N1Cc2nc(NCc3ccn(C)n3)ncc2C[C@H]1C |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	WIPO WO2022064009	n/a	n/a	3.16	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM50593925 (CHEMBL5196685) Show SMILES CN(C)\C=C\CC(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2ncc(Cl)c(n2)-c2cc3ccccc3[nH]2)c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.1c02064 BindingDB Entry DOI: 10.7270/Q2SB49QV
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM50110178 (CHEMBL3603847 | US10787436, Compound I-23) Show SMILES CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)c1 Show InChI InChI=1S/C31H28ClN7O2/c1-39(2)16-6-11-28(40)35-21-14-12-20(13-15-21)30(41)36-22-7-5-8-23(17-22)37-31-34-19-26(32)29(38-31)25-18-33-27-10-4-3-9-24(25)27/h3-15,17-19,33H,16H2,1-2H3,(H,35,40)(H,36,41)(H,34,37,38)/b11-6+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.1c02190 BindingDB Entry DOI: 10.7270/Q2BV7MPD
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM50110178 (CHEMBL3603847 | US10787436, Compound I-23) Show SMILES CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)c1 Show InChI InChI=1S/C31H28ClN7O2/c1-39(2)16-6-11-28(40)35-21-14-12-20(13-15-21)30(41)36-22-7-5-8-23(17-22)37-31-34-19-26(32)29(38-31)25-18-33-27-10-4-3-9-24(25)27/h3-15,17-19,33H,16H2,1-2H3,(H,35,40)(H,36,41)(H,34,37,38)/b11-6+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Competitive inhibition of human CDK7 in presence of ATP				Bioorg Med Chem Lett 25: 3420-35 (2015) Article DOI: 10.1016/j.bmcl.2015.05.100 BindingDB Entry DOI: 10.7270/Q2736SQ1
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM50110178 (CHEMBL3603847 | US10787436, Compound I-23) Show SMILES CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)c1 Show InChI InChI=1S/C31H28ClN7O2/c1-39(2)16-6-11-28(40)35-21-14-12-20(13-15-21)30(41)36-22-7-5-8-23(17-22)37-31-34-19-26(32)29(38-31)25-18-33-27-10-4-3-9-24(25)27/h3-15,17-19,33H,16H2,1-2H3,(H,35,40)(H,36,41)(H,34,37,38)/b11-6+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human CDK7 incubated for 180 mins by LanthaScreen Eu Kinase binding assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00766 BindingDB Entry DOI: 10.7270/Q2GX4G9M
					More data for this Ligand-Target Pair
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM530256 (WO2022064009, Compound 12) Show SMILES C[C@@H]1Cc2cnc(N[C@H]3CC[C@H](O)CC3)nc2CN1C(=O)[C@H]1CCN(C)C[C@@H]1c1ccccc1 |r,wU:27.31,8.7,1.0,wD:21.23,11.11,(-6.92,-4.58,;-5.58,-5.35,;-5.58,-6.89,;-4.25,-7.66,;-4.25,-9.2,;-2.92,-9.97,;-1.58,-9.2,;-.25,-9.97,;1.08,-9.2,;1.08,-7.66,;2.42,-6.89,;3.75,-7.66,;5.08,-6.89,;3.75,-9.2,;2.42,-9.97,;-1.58,-7.66,;-2.92,-6.89,;-2.92,-5.35,;-4.25,-4.58,;-4.25,-3.04,;-5.58,-2.27,;-2.92,-2.27,;-1.58,-3.04,;-.25,-2.27,;-.25,-.73,;1.08,.04,;-1.58,.04,;-2.92,-.73,;-4.25,.04,;-4.25,1.58,;-5.58,2.35,;-6.92,1.58,;-6.92,.04,;-5.58,-.73,)| Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	WIPO WO2022064009	n/a	n/a	3.24	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B
					More data for this Ligand-Target Pair
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM530286 (WO2022064009, Compound 156 | WO2022064009, Compoun...) Show SMILES C[C@@H]1Cc2cnc(NC3CCOCC3)nc2CN1C(=O)[C@H]1CCN(C)C[C@@H]1c1ccccc1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	WIPO WO2022064009	n/a	n/a	3.24	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B
					More data for this Ligand-Target Pair
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM530423 (WO2022064009, Compound 209) Show SMILES C[C@@H]1Cc2cnc(NC3CCN(CC3)S(C)(=O)=O)nc2CN1C(=O)N1CCN(C)C[C@@H]1c1ccccc1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	WIPO WO2022064009	n/a	n/a	3.31	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B
					More data for this Ligand-Target Pair
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM530424 (WO2022064009, Compound 210) Show SMILES C[C@@H]1Cc2cnc(NC3CCN(CC3)S(=O)(=O)C3CC3)nc2CN1C(=O)N1CCN(C)C[C@@H]1c1ccccc1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	WIPO WO2022064009	n/a	n/a	3.31	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B
					More data for this Ligand-Target Pair
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM530299 (WO2022064009, Compound 60) Show SMILES C[C@@H]1Cc2cnc(NCC3CN(C)C=C3)nc2CN1C(=O)[C@H]1CCN(C)C[C@@H]1c1ccccc1 |r,c:13| Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	WIPO WO2022064009	n/a	n/a	3.55	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B
					More data for this Ligand-Target Pair
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM530354 (WO2022064009, Compound 132) Show SMILES C[C@@H]1Cc2cnc(NC3CCOCC3)nc2CN1C(=O)[C@H]1CCN(C)C[C@@H]1c1ccc(Cl)cc1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	WIPO WO2022064009	n/a	n/a	3.63	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B
					More data for this Ligand-Target Pair
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM530339 (WO2022064009, Compound 126) Show SMILES C[C@@H]1Cc2cnc(Nc3cnn(C)c3)nc2CN1C(=O)[C@H]1CCN(C)C[C@@H]1c1cccc(C)c1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	WIPO WO2022064009	n/a	n/a	3.72	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B
					More data for this Ligand-Target Pair
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM530250 (WO2022064009, Compound 6) Show SMILES C[C@@H]1Cc2cnc(N[C@@H]3CCC(=O)N(C)C3)nc2CN1C(=O)[C@H]1CCN(C)C[C@@H]1c1ccccc1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	WIPO WO2022064009	n/a	n/a	3.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B
					More data for this Ligand-Target Pair

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