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Compile Data Set for Download or QSAR

Found 60 hits Enz. Inhib. hit(s) with all data for entry = 10128   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM515298
PNG
(US11098059, Example 2 | US11098059, Example 6)
Show SMILES CC[C@H]1CN(C[C@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2ccc(Br)cc12 |r|
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.210n/an/an/an/an/an/a


TBA

Assay Description
In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...

Citation and Details

BindingDB Entry DOI: 10.7270/Q26D5X5X
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM515310
PNG
(US11098059, Example 14)
Show SMILES CC[C@H]1CN(C[C@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2ccc(cc12)C(=O)N1C2CCC1COC2 |r|
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.240n/an/an/an/an/an/a


TBA

Assay Description
In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...

Citation and Details

BindingDB Entry DOI: 10.7270/Q26D5X5X
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM515307
PNG
(6'-(1-cyclopropyl-1H-1,2,4- triazol-5-yl)-2'-{(2R)...)
Show SMILES O[C@H](CN1CC2(CCC2)c2cc(ccc2C1=O)-c1ncnn1C1CC1)[C@@H]1Cc2ccccc2CN1 |r|
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.290n/an/an/an/an/an/a


TBA

Assay Description
In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...

Citation and Details

BindingDB Entry DOI: 10.7270/Q26D5X5X
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM515299
PNG
(US11098059, Example 3 | US11098059, Example 7)
Show SMILES CC[C@@H]1CN(C[C@@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2ccc(Br)cc12 |r|
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.310n/an/an/an/an/an/a


TBA

Assay Description
In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...

Citation and Details

BindingDB Entry DOI: 10.7270/Q26D5X5X
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM515323
PNG
(6-(hexahydro-3,6- epiminofuro[3,2-b]furan- 7-carbo...)
Show SMILES CC1(C)CN(C[C@@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2ccc(cc12)C(=O)N1C2COC3C1COC23 |r,TLB:26:28:30.31:36,30:29:32:34.35,31:32:28.29:34.35,THB:26:28:32:34.35,34:33:30.31:36,35:36:30.31:33.28|
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.350n/an/an/an/an/an/a


TBA

Assay Description
In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...

Citation and Details

BindingDB Entry DOI: 10.7270/Q26D5X5X
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM515309
PNG
(US11098059, Example 13)
Show SMILES CC[C@H]1CN(C[C@@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2ccc(cc12)C(=O)N1C2CCC1COC2 |r|
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.360n/an/an/an/an/an/a


TBA

Assay Description
In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...

Citation and Details

BindingDB Entry DOI: 10.7270/Q26D5X5X
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM515306
PNG
(6-(1-cyclopropyl-1H-1,2,4- triazol-5-yl)-4-ethyl-2...)
Show SMILES CCC1CN(C[C@@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2ccc(cc12)-c1ncnn1C1CC1 |r|
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.400n/an/an/an/an/an/a


TBA

Assay Description
In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...

Citation and Details

BindingDB Entry DOI: 10.7270/Q26D5X5X
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM515321
PNG
(2-((R)-2-hydroxy-2-((S)- 1,2,3,4- tetrahydroisoqui...)
Show SMILES CO[C@H]1C[C@@H]2CC[C@H](C1)N2C(=O)c1ccc2C(=O)N(C[C@@H](O)[C@@H]3Cc4ccccc4CN3)CC(C)(C)c2c1 |r,THB:10:9:8.2.3:6.5|
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.440n/an/an/an/an/an/a


TBA

Assay Description
In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...

Citation and Details

BindingDB Entry DOI: 10.7270/Q26D5X5X
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM515305
PNG
(6-(1-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-{(2R)-2-...)
Show SMILES CC1(C)CN(C[C@@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2ccc(cc12)-c1ncnn1C1CC1 |r|
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.470n/an/an/an/an/an/a


TBA

Assay Description
In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...

Citation and Details

BindingDB Entry DOI: 10.7270/Q26D5X5X
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM515319
PNG
(US11098059, Example 23)
Show SMILES CO[C@@H]1C[C@@H]2CC[C@H](C1)N2C(=O)c1ccc2C(=O)N(C[C@@H](O)[C@@H]3Cc4ccccc4CN3)CC(C)(C)c2c1 |r,THB:10:9:8.2.3:6.5|
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.5n/an/an/an/an/an/a


TBA

Assay Description
In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...

Citation and Details

BindingDB Entry DOI: 10.7270/Q26D5X5X
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM515317
PNG
(US11098059, Example 21)
Show SMILES CC1(C)CN(C[C@@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2ccc(cc12)C(=O)N1[C@H]2CC[C@@H]1C[C@H](O)C2 |r,THB:26:28:33.34.36:31.30|
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.520n/an/an/an/an/an/a


TBA

Assay Description
In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...

Citation and Details

BindingDB Entry DOI: 10.7270/Q26D5X5X
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM515315
PNG
(US11098059, Example 19)
Show SMILES CC1(C)CN(C[C@@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2ccc(cc12)C(=O)N1C2CCC1COC2 |r|
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.530n/an/an/an/an/an/a


TBA

Assay Description
In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...

Citation and Details

BindingDB Entry DOI: 10.7270/Q26D5X5X
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM515313
PNG
(US11098059, Example 17)
Show SMILES CC1(C)CN(C[C@@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2ccc(Br)cc12 |r|
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.610n/an/an/an/an/an/a


TBA

Assay Description
In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...

Citation and Details

BindingDB Entry DOI: 10.7270/Q26D5X5X
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM515308
PNG
(4-ethyl-2-{2-hydroxy-2-[(3S)-1,2,3,4-tetrahydroiso...)
Show SMILES CCC1CN(CC(O)[C@@H]2Cc3ccccc3CN2)C(=O)c2ccc(cc12)C(=O)N1C2CCC1COC2 |r|
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.630n/an/an/an/an/an/a


TBA

Assay Description
In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...

Citation and Details

BindingDB Entry DOI: 10.7270/Q26D5X5X
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM515325
PNG
(2-{(2R)-2-hydroxy-2-[(3S)-1,2,3,4-tetrahydroisoqui...)
Show SMILES CC1(C)CN(C[C@@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2ccc(cc12)N1C2CCC(CC2)C1=O |r,wU:6.6,wD:8.7,(-2.1,2.87,;-1.33,1.54,;-.56,2.87,;,.77,;,-.77,;1.33,-1.54,;2.67,-.77,;2.67,.77,;4,-1.54,;5.33,-.77,;6.67,-1.54,;8,-.77,;9.34,-1.54,;9.34,-3.08,;8,-3.85,;6.67,-3.08,;5.33,-3.85,;4,-3.08,;-1.33,-1.54,;-1.33,-3.08,;-2.67,-.77,;-4,-1.54,;-5.33,-.77,;-5.33,.77,;-4,1.54,;-2.67,.77,;-6.67,1.54,;-6.67,3.08,;-8,3.85,;-9.34,3.08,;-9.34,1.54,;-8.53,2.84,;-7.44,1.75,;-8,.77,;-8,-.77,)|
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.840n/an/an/an/an/an/a


TBA

Assay Description
In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...

Citation and Details

BindingDB Entry DOI: 10.7270/Q26D5X5X
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM515298
PNG
(US11098059, Example 2 | US11098059, Example 6)
Show SMILES CC[C@H]1CN(C[C@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2ccc(Br)cc12 |r|
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3.82n/an/an/an/an/an/a


TBA

Assay Description
In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...

Citation and Details

BindingDB Entry DOI: 10.7270/Q26D5X5X
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM515297
PNG
(US11098059, Example 1 | US11098059, Example 5)
Show SMILES CC[C@H]1CN(C[C@@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2ccc(Br)cc12 |r|
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5.38n/an/an/an/an/an/a


TBA

Assay Description
In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...

Citation and Details

BindingDB Entry DOI: 10.7270/Q26D5X5X
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM515311
PNG
(US11098059, Example 15)
Show SMILES CC[C@@H]1CN(C[C@@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2ccc(cc12)C(=O)N1C2CCC1COC2 |r|
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 9.54n/an/an/an/an/an/a


TBA

Assay Description
In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...

Citation and Details

BindingDB Entry DOI: 10.7270/Q26D5X5X
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM515320
PNG
(US11098059, Example 24)
Show SMILES CO[C@@H]1C[C@@H]2CC[C@H](C1)N2C(=O)c1ccc2C(=O)N(C[C@H](O)[C@@H]3Cc4ccccc4CN3)CC(C)(C)c2c1 |r,THB:10:9:8.2.3:6.5|
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 11.3n/an/an/an/an/an/a


TBA

Assay Description
In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...

Citation and Details

BindingDB Entry DOI: 10.7270/Q26D5X5X
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM515316
PNG
(US11098059, Example 20)
Show SMILES CC1(C)CN(C[C@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2ccc(cc12)C(=O)N1C2CCC1COC2 |r|
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 12.9n/an/an/an/an/an/a


TBA

Assay Description
In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...

Citation and Details

BindingDB Entry DOI: 10.7270/Q26D5X5X
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM515326
PNG
(2-{2-hydroxy-2-[(3S)-1,2,3,4-tetrahydroisoquinolin...)
Show SMILES OC(CN1CCc2cc(ccc2C1=O)C(=O)N1C2CCC1COC2)[C@@H]1Cc2ccccc2CN1 |r|
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 16.6n/an/an/an/an/an/a


TBA

Assay Description
In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...

Citation and Details

BindingDB Entry DOI: 10.7270/Q26D5X5X
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM515312
PNG
(US11098059, Example 16)
Show SMILES CC[C@@H]1CN(C[C@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2ccc(cc12)C(=O)N1C2CCC1COC2 |r|
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 17.6n/an/an/an/an/an/a


TBA

Assay Description
In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...

Citation and Details

BindingDB Entry DOI: 10.7270/Q26D5X5X
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM515322
PNG
(2-((S)-2-hydroxy-2-((S)- 1,2,3,4- tetrahydroisoqui...)
Show SMILES CO[C@H]1C[C@@H]2CC[C@H](C1)N2C(=O)c1ccc2C(=O)N(C[C@H](O)[C@@H]3Cc4ccccc4CN3)CC(C)(C)c2c1 |r,THB:10:9:8.2.3:6.5|
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 24.3n/an/an/an/an/an/a


TBA

Assay Description
In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...

Citation and Details

BindingDB Entry DOI: 10.7270/Q26D5X5X
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM515310
PNG
(US11098059, Example 14)
Show SMILES CC[C@H]1CN(C[C@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2ccc(cc12)C(=O)N1C2CCC1COC2 |r|
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 31.7n/an/an/an/an/an/a


TBA

Assay Description
In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...

Citation and Details

BindingDB Entry DOI: 10.7270/Q26D5X5X
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM515324
PNG
(6-(hexahydro-3,6- epiminofuro[3,2-b]furan- 7-carbo...)
Show SMILES CC1(C)CN(C[C@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2ccc(cc12)C(=O)N1C2COC3C1COC23 |r,TLB:26:28:30.31:36,30:29:32:34.35,31:32:28.29:34.35,THB:26:28:32:34.35,34:33:30.31:36,35:36:30.31:33.28|
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 34.3n/an/an/an/an/an/a


TBA

Assay Description
In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...

Citation and Details

BindingDB Entry DOI: 10.7270/Q26D5X5X
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM515300
PNG
(US11098059, Example 4 | US11098059, Example 8)
Show SMILES CC[C@@H]1CN(C[C@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2ccc(Br)cc12 |r|
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 45.8n/an/an/an/an/an/a


TBA

Assay Description
In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...

Citation and Details

BindingDB Entry DOI: 10.7270/Q26D5X5X
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM515300
PNG
(US11098059, Example 4 | US11098059, Example 8)
Show SMILES CC[C@@H]1CN(C[C@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2ccc(Br)cc12 |r|
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n/an/a 49n/an/an/an/an/an/a


TBA

Assay Description
In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...

Citation and Details

BindingDB Entry DOI: 10.7270/Q26D5X5X
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM515318
PNG
(US11098059, Example 22)
Show SMILES CC1(C)CN(C[C@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2ccc(cc12)C(=O)N1[C@H]2CC[C@@H]1C[C@H](O)C2 |r,THB:26:28:33.34.36:31.30|
PDB

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n/an/a 50.1n/an/an/an/an/an/a


TBA

Assay Description
In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...

Citation and Details

BindingDB Entry DOI: 10.7270/Q26D5X5X
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM515321
PNG
(2-((R)-2-hydroxy-2-((S)- 1,2,3,4- tetrahydroisoqui...)
Show SMILES CO[C@H]1C[C@@H]2CC[C@H](C1)N2C(=O)c1ccc2C(=O)N(C[C@@H](O)[C@@H]3Cc4ccccc4CN3)CC(C)(C)c2c1 |r,THB:10:9:8.2.3:6.5|
PDB

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n/an/a 50.1n/an/an/an/an/an/a


TBA

Assay Description
In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...

Citation and Details

BindingDB Entry DOI: 10.7270/Q26D5X5X
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM515317
PNG
(US11098059, Example 21)
Show SMILES CC1(C)CN(C[C@@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2ccc(cc12)C(=O)N1[C@H]2CC[C@@H]1C[C@H](O)C2 |r,THB:26:28:33.34.36:31.30|
PDB

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n/an/a 88.1n/an/an/an/an/an/a


TBA

Assay Description
In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...

Citation and Details

BindingDB Entry DOI: 10.7270/Q26D5X5X
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM515319
PNG
(US11098059, Example 23)
Show SMILES CO[C@@H]1C[C@@H]2CC[C@H](C1)N2C(=O)c1ccc2C(=O)N(C[C@@H](O)[C@@H]3Cc4ccccc4CN3)CC(C)(C)c2c1 |r,THB:10:9:8.2.3:6.5|
PDB

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n/an/a 97.7n/an/an/an/an/an/a


TBA

Assay Description
In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...

Citation and Details

BindingDB Entry DOI: 10.7270/Q26D5X5X
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM515323
PNG
(6-(hexahydro-3,6- epiminofuro[3,2-b]furan- 7-carbo...)
Show SMILES CC1(C)CN(C[C@@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2ccc(cc12)C(=O)N1C2COC3C1COC23 |r,TLB:26:28:30.31:36,30:29:32:34.35,31:32:28.29:34.35,THB:26:28:32:34.35,34:33:30.31:36,35:36:30.31:33.28|
PDB

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n/an/a 115n/an/an/an/an/an/a


TBA

Assay Description
In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...

Citation and Details

BindingDB Entry DOI: 10.7270/Q26D5X5X
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM515307
PNG
(6'-(1-cyclopropyl-1H-1,2,4- triazol-5-yl)-2'-{(2R)...)
Show SMILES O[C@H](CN1CC2(CCC2)c2cc(ccc2C1=O)-c1ncnn1C1CC1)[C@@H]1Cc2ccccc2CN1 |r|
PDB

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n/an/a 127n/an/an/an/an/an/a


TBA

Assay Description
In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...

Citation and Details

BindingDB Entry DOI: 10.7270/Q26D5X5X
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM515315
PNG
(US11098059, Example 19)
Show SMILES CC1(C)CN(C[C@@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2ccc(cc12)C(=O)N1C2CCC1COC2 |r|
PDB

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n/an/a 138n/an/an/an/an/an/a


TBA

Assay Description
In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...

Citation and Details

BindingDB Entry DOI: 10.7270/Q26D5X5X
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM515298
PNG
(US11098059, Example 2 | US11098059, Example 6)
Show SMILES CC[C@H]1CN(C[C@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2ccc(Br)cc12 |r|
PDB

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n/an/a 172n/an/an/an/an/an/a


TBA

Assay Description
In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...

Citation and Details

BindingDB Entry DOI: 10.7270/Q26D5X5X
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM515314
PNG
(US11098059, Example 18)
Show SMILES CC1(C)CN(C[C@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2ccc(Br)cc12 |r|
PDB

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n/an/a 225n/an/an/an/an/an/a


TBA

Assay Description
In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...

Citation and Details

BindingDB Entry DOI: 10.7270/Q26D5X5X
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM515308
PNG
(4-ethyl-2-{2-hydroxy-2-[(3S)-1,2,3,4-tetrahydroiso...)
Show SMILES CCC1CN(CC(O)[C@@H]2Cc3ccccc3CN2)C(=O)c2ccc(cc12)C(=O)N1C2CCC1COC2 |r|
PDB

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n/an/a 253n/an/an/an/an/an/a


TBA

Assay Description
In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...

Citation and Details

BindingDB Entry DOI: 10.7270/Q26D5X5X
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM515309
PNG
(US11098059, Example 13)
Show SMILES CC[C@H]1CN(C[C@@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2ccc(cc12)C(=O)N1C2CCC1COC2 |r|
PDB

UniProtKB/SwissProt

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n/an/a 270n/an/an/an/an/an/a


TBA

Assay Description
In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...

Citation and Details

BindingDB Entry DOI: 10.7270/Q26D5X5X
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM515299
PNG
(US11098059, Example 3 | US11098059, Example 7)
Show SMILES CC[C@@H]1CN(C[C@@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2ccc(Br)cc12 |r|
PDB

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n/an/a 313n/an/an/an/an/an/a


TBA

Assay Description
In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...

Citation and Details

BindingDB Entry DOI: 10.7270/Q26D5X5X
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM515325
PNG
(2-{(2R)-2-hydroxy-2-[(3S)-1,2,3,4-tetrahydroisoqui...)
Show SMILES CC1(C)CN(C[C@@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2ccc(cc12)N1C2CCC(CC2)C1=O |r,wU:6.6,wD:8.7,(-2.1,2.87,;-1.33,1.54,;-.56,2.87,;,.77,;,-.77,;1.33,-1.54,;2.67,-.77,;2.67,.77,;4,-1.54,;5.33,-.77,;6.67,-1.54,;8,-.77,;9.34,-1.54,;9.34,-3.08,;8,-3.85,;6.67,-3.08,;5.33,-3.85,;4,-3.08,;-1.33,-1.54,;-1.33,-3.08,;-2.67,-.77,;-4,-1.54,;-5.33,-.77,;-5.33,.77,;-4,1.54,;-2.67,.77,;-6.67,1.54,;-6.67,3.08,;-8,3.85,;-9.34,3.08,;-9.34,1.54,;-8.53,2.84,;-7.44,1.75,;-8,.77,;-8,-.77,)|
PDB

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n/an/a 359n/an/an/an/an/an/a


TBA

Assay Description
In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...

Citation and Details

BindingDB Entry DOI: 10.7270/Q26D5X5X
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM515313
PNG
(US11098059, Example 17)
Show SMILES CC1(C)CN(C[C@@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2ccc(Br)cc12 |r|
PDB

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n/an/a 368n/an/an/an/an/an/a


TBA

Assay Description
In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...

Citation and Details

BindingDB Entry DOI: 10.7270/Q26D5X5X
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM515306
PNG
(6-(1-cyclopropyl-1H-1,2,4- triazol-5-yl)-4-ethyl-2...)
Show SMILES CCC1CN(C[C@@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2ccc(cc12)-c1ncnn1C1CC1 |r|
PDB

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n/an/a 374n/an/an/an/an/an/a


TBA

Assay Description
In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...

Citation and Details

BindingDB Entry DOI: 10.7270/Q26D5X5X
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM515299
PNG
(US11098059, Example 3 | US11098059, Example 7)
Show SMILES CC[C@@H]1CN(C[C@@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2ccc(Br)cc12 |r|
PDB

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n/an/a 411n/an/an/an/an/an/a


TBA

Assay Description
In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...

Citation and Details

BindingDB Entry DOI: 10.7270/Q26D5X5X
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM515305
PNG
(6-(1-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-{(2R)-2-...)
Show SMILES CC1(C)CN(C[C@@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2ccc(cc12)-c1ncnn1C1CC1 |r|
PDB

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n/an/a 422n/an/an/an/an/an/a


TBA

Assay Description
In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...

Citation and Details

BindingDB Entry DOI: 10.7270/Q26D5X5X
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM515297
PNG
(US11098059, Example 1 | US11098059, Example 5)
Show SMILES CC[C@H]1CN(C[C@@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2ccc(Br)cc12 |r|
PDB

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n/an/a 465n/an/an/an/an/an/a


TBA

Assay Description
In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...

Citation and Details

BindingDB Entry DOI: 10.7270/Q26D5X5X
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM515311
PNG
(US11098059, Example 15)
Show SMILES CC[C@@H]1CN(C[C@@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2ccc(cc12)C(=O)N1C2CCC1COC2 |r|
PDB

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n/an/a 3.21E+3n/an/an/an/an/an/a


TBA

Assay Description
In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...

Citation and Details

BindingDB Entry DOI: 10.7270/Q26D5X5X
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM515297
PNG
(US11098059, Example 1 | US11098059, Example 5)
Show SMILES CC[C@H]1CN(C[C@@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2ccc(Br)cc12 |r|
PDB

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n/an/a 3.74E+3n/an/an/an/an/an/a


TBA

Assay Description
In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...

Citation and Details

BindingDB Entry DOI: 10.7270/Q26D5X5X
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM515316
PNG
(US11098059, Example 20)
Show SMILES CC1(C)CN(C[C@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2ccc(cc12)C(=O)N1C2CCC1COC2 |r|
PDB

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n/an/a 4.07E+3n/an/an/an/an/an/a


TBA

Assay Description
In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...

Citation and Details

BindingDB Entry DOI: 10.7270/Q26D5X5X
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM515298
PNG
(US11098059, Example 2 | US11098059, Example 6)
Show SMILES CC[C@H]1CN(C[C@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2ccc(Br)cc12 |r|
PDB

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n/an/a 5.08E+3n/an/an/an/an/an/a


TBA

Assay Description
In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...

Citation and Details

BindingDB Entry DOI: 10.7270/Q26D5X5X
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM515326
PNG
(2-{2-hydroxy-2-[(3S)-1,2,3,4-tetrahydroisoquinolin...)
Show SMILES OC(CN1CCc2cc(ccc2C1=O)C(=O)N1C2CCC1COC2)[C@@H]1Cc2ccccc2CN1 |r|
PDB

UniProtKB/SwissProt

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n/an/a 6.28E+3n/an/an/an/an/an/a


TBA

Assay Description
In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...

Citation and Details

BindingDB Entry DOI: 10.7270/Q26D5X5X
More data for this
Ligand-Target Pair
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