BindingDB PrimarySearch

Found 18 hits Enz. Inhib. hit(s) with all data for entry = 50006078
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Aromatase (Homo sapiens (Human))	BDBM50044424 (4-(((2S,4S)-2-((1H-imidazol-1-yl)methyl)-2-(4-chlo...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	7.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Syntex Discovery Research Curated by ChEMBL					Assay Description Binding affinity for Cytochrome P450 19A1				J Med Chem 36: 2235-7 (1993) BindingDB Entry DOI: 10.7270/Q2ZW1K0P
Syntex Discovery Research Curated by ChEMBL					More data for this Ligand-Target Pair
Lanosterol 14-alpha demethylase (Rattus norvegicus)	BDBM50161586 (4-{(2S,4R)-2-[2-(4-Chloro-phenyl)-ethyl]-2-imidazo...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	11	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Syntex Discovery Research Curated by ChEMBL					Assay Description Apparent Ki for rat Lanosterol 14-alpha demethylase				J Med Chem 36: 2235-7 (1993) BindingDB Entry DOI: 10.7270/Q2ZW1K0P
Syntex Discovery Research Curated by ChEMBL					More data for this Ligand-Target Pair
Aromatase (Homo sapiens (Human))	BDBM50044425 (4-{(2R,4R)-2-[2-(4-Chloro-phenyl)-ethyl]-2-imidazo...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	13	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Syntex Discovery Research Curated by ChEMBL					Assay Description Binding affinity for Cytochrome P450 19A1				J Med Chem 36: 2235-7 (1993) BindingDB Entry DOI: 10.7270/Q2ZW1K0P
Syntex Discovery Research Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 11B1, mitochondrial (Homo sapiens (Human))	BDBM50044425 (4-{(2R,4R)-2-[2-(4-Chloro-phenyl)-ethyl]-2-imidazo...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	15	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Syntex Discovery Research Curated by ChEMBL					Assay Description Binding affinity for corticoid 11-beta-hydroxylase				J Med Chem 36: 2235-7 (1993) BindingDB Entry DOI: 10.7270/Q2ZW1K0P
Syntex Discovery Research Curated by ChEMBL					More data for this Ligand-Target Pair
Lanosterol 14-alpha demethylase (Homo sapiens (Human))	BDBM31768 (CHEMBL295698 \| Ketoconazole \| Nizoral \| Panfungol) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	25	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Syntex Discovery Research Curated by ChEMBL					Assay Description Inhibition of lanosterol 14-alpha-demethylase in hamster hepatic microsomes				J Med Chem 36: 2235-7 (1993) BindingDB Entry DOI: 10.7270/Q2ZW1K0P
Syntex Discovery Research Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50044424 (4-(((2S,4S)-2-((1H-imidazol-1-yl)methyl)-2-(4-chlo...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	28	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Syntex Discovery Research Curated by ChEMBL					Assay Description Binding affinity for progesterone 6-beta-hydroxylase of hepatic microsomes				J Med Chem 36: 2235-7 (1993) BindingDB Entry DOI: 10.7270/Q2ZW1K0P
Syntex Discovery Research Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50044425 (4-{(2R,4R)-2-[2-(4-Chloro-phenyl)-ethyl]-2-imidazo...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	33	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Syntex Discovery Research Curated by ChEMBL					Assay Description Binding affinity for progesterone 6-beta-hydroxylase of hepatic microsomes				J Med Chem 36: 2235-7 (1993) BindingDB Entry DOI: 10.7270/Q2ZW1K0P
Syntex Discovery Research Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 11B1, mitochondrial (Homo sapiens (Human))	BDBM50044424 (4-(((2S,4S)-2-((1H-imidazol-1-yl)methyl)-2-(4-chlo...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	35	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Syntex Discovery Research Curated by ChEMBL					Assay Description Binding affinity for corticoid 11-beta-hydroxylase				J Med Chem 36: 2235-7 (1993) BindingDB Entry DOI: 10.7270/Q2ZW1K0P
Syntex Discovery Research Curated by ChEMBL					More data for this Ligand-Target Pair
Lanosterol 14-alpha demethylase (Rattus norvegicus)	BDBM50044425 (4-{(2R,4R)-2-[2-(4-Chloro-phenyl)-ethyl]-2-imidazo...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	37	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Syntex Discovery Research Curated by ChEMBL					Assay Description Inhibition of lanosterol 14-alpha-demethylase of rat hepatic microsomes				J Med Chem 36: 2235-7 (1993) BindingDB Entry DOI: 10.7270/Q2ZW1K0P
Syntex Discovery Research Curated by ChEMBL					More data for this Ligand-Target Pair
Lanosterol 14-alpha demethylase (Homo sapiens (Human))	BDBM50044425 (4-{(2R,4R)-2-[2-(4-Chloro-phenyl)-ethyl]-2-imidazo...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Syntex Discovery Research Curated by ChEMBL					Assay Description Inhibition of lanosterol 14-alpha-demethylase in hamster hepatic microsomes				J Med Chem 36: 2235-7 (1993) BindingDB Entry DOI: 10.7270/Q2ZW1K0P
Syntex Discovery Research Curated by ChEMBL					More data for this Ligand-Target Pair
Lanosterol 14-alpha demethylase (Homo sapiens (Human))	BDBM50044425 (4-{(2R,4R)-2-[2-(4-Chloro-phenyl)-ethyl]-2-imidazo...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	40.4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Syntex Discovery Research Curated by ChEMBL					Assay Description Inhibition of lanosterol 14-alpha-demethylase in hamster hepatic microsomes				J Med Chem 36: 2235-7 (1993) BindingDB Entry DOI: 10.7270/Q2ZW1K0P
Syntex Discovery Research Curated by ChEMBL					More data for this Ligand-Target Pair
Steroid 17-alpha-hydroxylase/17,20 lyase (Homo sapiens (Human))	BDBM50044425 (4-{(2R,4R)-2-[2-(4-Chloro-phenyl)-ethyl]-2-imidazo...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	54	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Syntex Discovery Research Curated by ChEMBL					Assay Description Binding affinity for progesterone 17alpha,20-lyase				J Med Chem 36: 2235-7 (1993) BindingDB Entry DOI: 10.7270/Q2ZW1K0P
Syntex Discovery Research Curated by ChEMBL					More data for this Ligand-Target Pair
Lanosterol 14-alpha demethylase (Homo sapiens (Human))	BDBM31768 (CHEMBL295698 \| Ketoconazole \| Nizoral \| Panfungol) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	64	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Syntex Discovery Research Curated by ChEMBL					Assay Description Inhibition of lanosterol 14-alpha-demethylase in hamster hepatic microsomes				J Med Chem 36: 2235-7 (1993) BindingDB Entry DOI: 10.7270/Q2ZW1K0P
Syntex Discovery Research Curated by ChEMBL					More data for this Ligand-Target Pair
Lanosterol 14-alpha demethylase (Rattus norvegicus)	BDBM31768 (CHEMBL295698 \| Ketoconazole \| Nizoral \| Panfungol) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	65	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Syntex Discovery Research Curated by ChEMBL					Assay Description Inhibition of lanosterol 14-alpha-demethylase of rat hepatic microsomes				J Med Chem 36: 2235-7 (1993) BindingDB Entry DOI: 10.7270/Q2ZW1K0P
Syntex Discovery Research Curated by ChEMBL					More data for this Ligand-Target Pair
Steroid 17-alpha-hydroxylase/17,20 lyase (Homo sapiens (Human))	BDBM50044425 (4-{(2R,4R)-2-[2-(4-Chloro-phenyl)-ethyl]-2-imidazo...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	109	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Syntex Discovery Research Curated by ChEMBL					Assay Description Binding affinity for cholesterol 17-alpha-hydroxylase				J Med Chem 36: 2235-7 (1993) BindingDB Entry DOI: 10.7270/Q2ZW1K0P
Syntex Discovery Research Curated by ChEMBL					More data for this Ligand-Target Pair
Lanosterol 14-alpha demethylase (Rattus norvegicus)	BDBM31653 (CHEMBL421109 \| imidazole-dioxolane, 5) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	117	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Syntex Discovery Research Curated by ChEMBL					Assay Description Apparent Ki for rat Lanosterol 14-alpha demethylase				J Med Chem 36: 2235-7 (1993) BindingDB Entry DOI: 10.7270/Q2ZW1K0P
Syntex Discovery Research Curated by ChEMBL					More data for this Ligand-Target Pair
Steroid 17-alpha-hydroxylase/17,20 lyase (Homo sapiens (Human))	BDBM50044424 (4-(((2S,4S)-2-((1H-imidazol-1-yl)methyl)-2-(4-chlo...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	447	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Syntex Discovery Research Curated by ChEMBL					Assay Description Binding affinity for progesterone 17-alpha,20-lyase				J Med Chem 36: 2235-7 (1993) BindingDB Entry DOI: 10.7270/Q2ZW1K0P
Syntex Discovery Research Curated by ChEMBL					More data for this Ligand-Target Pair
Steroid 17-alpha-hydroxylase/17,20 lyase (Homo sapiens (Human))	BDBM50044424 (4-(((2S,4S)-2-((1H-imidazol-1-yl)methyl)-2-(4-chlo...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	1.63E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Syntex Discovery Research Curated by ChEMBL					Assay Description Binding affinity for cholesterol 17-alpha-hydroxylase				J Med Chem 36: 2235-7 (1993) BindingDB Entry DOI: 10.7270/Q2ZW1K0P
Syntex Discovery Research Curated by ChEMBL					More data for this Ligand-Target Pair