Compile Data Set for Download or QSAR

Found 79 hits Enz. Inhib. hit(s) with all data for entry = 50005872   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dihydrofolate reductase (Homo sapiens (Human))	BDBM18268 (5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...) Show SMILES COc1cc(NCc2ccc3nc(N)nc(N)c3c2C)cc(OC)c1OC Show InChI InChI=1S/C19H23N5O3/c1-10-11(5-6-13-16(10)18(20)24-19(21)23-13)9-22-12-7-14(25-2)17(27-4)15(8-12)26-3/h5-8,22H,9H2,1-4H3,(H4,20,21,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Tested for inhibitory activity against dihydrofolate reductase in human				J Med Chem 36: 3103-12 (1993) BindingDB Entry DOI: 10.7270/Q23X85PX
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM18224 (6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3...) Show SMILES COc1ccc(OC)c(Cc2cnc3nc(N)nc(N)c3c2C)c1 Show InChI InChI=1S/C17H19N5O2/c1-9-11(6-10-7-12(23-2)4-5-13(10)24-3)8-20-16-14(9)15(18)21-17(19)22-16/h4-5,7-8H,6H2,1-3H3,(H4,18,19,20,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of rat liver dihydrofolate reductase.				J Med Chem 36: 3103-12 (1993) BindingDB Entry DOI: 10.7270/Q23X85PX
					More data for this Ligand-Target Pair				3D Structure (crystal)
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM18268 (5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...) Show SMILES COc1cc(NCc2ccc3nc(N)nc(N)c3c2C)cc(OC)c1OC Show InChI InChI=1S/C19H23N5O3/c1-10-11(5-6-13-16(10)18(20)24-19(21)23-13)9-22-12-7-14(25-2)17(27-4)15(8-12)26-3/h5-8,22H,9H2,1-4H3,(H4,20,21,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of rat liver dihydrofolate reductase.				J Med Chem 36: 3103-12 (1993) BindingDB Entry DOI: 10.7270/Q23X85PX
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Escherichia coli)	BDBM18268 (5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...) Show SMILES COc1cc(NCc2ccc3nc(N)nc(N)c3c2C)cc(OC)c1OC Show InChI InChI=1S/C19H23N5O3/c1-10-11(5-6-13-16(10)18(20)24-19(21)23-13)9-22-12-7-14(25-2)17(27-4)15(8-12)26-3/h5-8,22H,9H2,1-4H3,(H4,20,21,23,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of dihydrofolate reductase in Toxoplasma gondii.				J Med Chem 36: 3103-12 (1993) BindingDB Entry DOI: 10.7270/Q23X85PX
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Escherichia coli)	BDBM18224 (6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3...) Show SMILES COc1ccc(OC)c(Cc2cnc3nc(N)nc(N)c3c2C)c1 Show InChI InChI=1S/C17H19N5O2/c1-9-11(6-10-7-12(23-2)4-5-13(10)24-3)8-20-16-14(9)15(18)21-17(19)22-16/h4-5,7-8H,6H2,1-3H3,(H4,18,19,20,21,22)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of dihydrofolate reductase in pneumocystis carinii.				J Med Chem 36: 3103-12 (1993) BindingDB Entry DOI: 10.7270/Q23X85PX
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Escherichia coli)	BDBM18224 (6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3...) Show SMILES COc1ccc(OC)c(Cc2cnc3nc(N)nc(N)c3c2C)c1 Show InChI InChI=1S/C17H19N5O2/c1-9-11(6-10-7-12(23-2)4-5-13(10)24-3)8-20-16-14(9)15(18)21-17(19)22-16/h4-5,7-8H,6H2,1-3H3,(H4,18,19,20,21,22)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	38	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of dihydrofolate reductase in pneumocystis carinii.				J Med Chem 36: 3103-12 (1993) BindingDB Entry DOI: 10.7270/Q23X85PX
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Escherichia coli)	BDBM18268 (5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...) Show SMILES COc1cc(NCc2ccc3nc(N)nc(N)c3c2C)cc(OC)c1OC Show InChI InChI=1S/C19H23N5O3/c1-10-11(5-6-13-16(10)18(20)24-19(21)23-13)9-22-12-7-14(25-2)17(27-4)15(8-12)26-3/h5-8,22H,9H2,1-4H3,(H4,20,21,23,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of dihydrofolate reductase in pneumocystis carinii.				J Med Chem 36: 3103-12 (1993) BindingDB Entry DOI: 10.7270/Q23X85PX
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Escherichia coli)	BDBM50041943 (6-(2,5-Dimethoxy-benzyl)-5-methyl-thieno[2,3-d]pyr...) Show SMILES COc1ccc(OC)c(Cc2sc3nc(N)nc(N)c3c2C)c1 Show InChI InChI=1S/C16H18N4O2S/c1-8-12(23-15-13(8)14(17)19-16(18)20-15)7-9-6-10(21-2)4-5-11(9)22-3/h4-6H,7H2,1-3H3,(H4,17,18,19,20)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of dihydrofolate reductase in Toxoplasma gondii.				J Med Chem 36: 3103-12 (1993) BindingDB Entry DOI: 10.7270/Q23X85PX
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Escherichia coli)	BDBM50041929 (6-(2,5-Dimethoxy-phenyl)-5-methyl-thieno[2,3-d]pyr...) Show SMILES COc1ccc(OC)c(c1)-c1sc2nc(N)nc(N)c2c1C Show InChI InChI=1S/C15H16N4O2S/c1-7-11-13(16)18-15(17)19-14(11)22-12(7)9-6-8(20-2)4-5-10(9)21-3/h4-6H,1-3H3,(H4,16,17,18,19)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of dihydrofolate reductase in Toxoplasma gondii.				J Med Chem 36: 3103-12 (1993) BindingDB Entry DOI: 10.7270/Q23X85PX
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Lactobacillus casei)	BDBM50041927 (5,6,7,8,9,10,11,12,13,14-Decahydro-15-thia-1,3-dia...) Show SMILES Nc1nc(N)c2c3CCCCCCCCCCc3sc2n1 Show InChI InChI=1S/C16H24N4S/c17-14-13-11-9-7-5-3-1-2-4-6-8-10-12(11)21-15(13)20-16(18)19-14/h1-10H2,(H4,17,18,19,20)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of dihydrofolate reductase in Toxoplasma gondii.				J Med Chem 36: 3103-12 (1993) BindingDB Entry DOI: 10.7270/Q23X85PX
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Escherichia coli)	BDBM50041939 (5-Methyl-6-(3,4,5-trimethoxy-phenyl)-thieno[2,3-d]...) Show SMILES COc1cc(cc(OC)c1OC)-c1sc2nc(N)nc(N)c2c1C Show InChI InChI=1S/C16H18N4O3S/c1-7-11-14(17)19-16(18)20-15(11)24-13(7)8-5-9(21-2)12(23-4)10(6-8)22-3/h5-6H,1-4H3,(H4,17,18,19,20)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	320	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of dihydrofolate reductase in Toxoplasma gondii.				J Med Chem 36: 3103-12 (1993) BindingDB Entry DOI: 10.7270/Q23X85PX
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM50041929 (6-(2,5-Dimethoxy-phenyl)-5-methyl-thieno[2,3-d]pyr...) Show SMILES COc1ccc(OC)c(c1)-c1sc2nc(N)nc(N)c2c1C Show InChI InChI=1S/C15H16N4O2S/c1-7-11-13(16)18-15(17)19-14(11)22-12(7)9-6-8(20-2)4-5-10(9)21-3/h4-6H,1-3H3,(H4,16,17,18,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of rat liver dihydrofolate reductase.				J Med Chem 36: 3103-12 (1993) BindingDB Entry DOI: 10.7270/Q23X85PX
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Lactobacillus casei)	BDBM50041935 (5,6,7,8,9,10-Hexahydro-11-thia-1,3-diaza-cycloocta...) Show SMILES Nc1nc(N)c2c3CCCCCCc3sc2n1 Show InChI InChI=1S/C12H16N4S/c13-10-9-7-5-3-1-2-4-6-8(7)17-11(9)16-12(14)15-10/h1-6H2,(H4,13,14,15,16)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Tested for inhibitory activity against dihydrofolate reductase in Beef liver				J Med Chem 36: 3103-12 (1993) BindingDB Entry DOI: 10.7270/Q23X85PX
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM50041943 (6-(2,5-Dimethoxy-benzyl)-5-methyl-thieno[2,3-d]pyr...) Show SMILES COc1ccc(OC)c(Cc2sc3nc(N)nc(N)c3c2C)c1 Show InChI InChI=1S/C16H18N4O2S/c1-8-12(23-15-13(8)14(17)19-16(18)20-15)7-9-6-10(21-2)4-5-11(9)22-3/h4-6H,7H2,1-3H3,(H4,17,18,19,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of rat liver dihydrofolate reductase.				J Med Chem 36: 3103-12 (1993) BindingDB Entry DOI: 10.7270/Q23X85PX
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM50041928 (7-Benzyl-5,6,7,8-tetrahydro-9-thia-1,3,7-triaza-fl...) Show SMILES Nc1nc(N)c2c3CCN(Cc4ccccc4)Cc3sc2n1 Show InChI InChI=1S/C16H17N5S/c17-14-13-11-6-7-21(8-10-4-2-1-3-5-10)9-12(11)22-15(13)20-16(18)19-14/h1-5H,6-9H2,(H4,17,18,19,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	570	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of rat liver dihydrofolate reductase.				J Med Chem 36: 3103-12 (1993) BindingDB Entry DOI: 10.7270/Q23X85PX
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Escherichia coli)	BDBM50041934 (5-Methyl-6-(3,4,5-trimethoxy-benzyl)-thieno[2,3-d]...) Show SMILES COc1cc(Cc2sc3nc(N)nc(N)c3c2C)cc(OC)c1OC Show InChI InChI=1S/C17H20N4O3S/c1-8-12(25-16-13(8)15(18)20-17(19)21-16)7-9-5-10(22-2)14(24-4)11(6-9)23-3/h5-6H,7H2,1-4H3,(H4,18,19,20,21)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	630	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of dihydrofolate reductase in Toxoplasma gondii.				J Med Chem 36: 3103-12 (1993) BindingDB Entry DOI: 10.7270/Q23X85PX
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Lactobacillus casei)	BDBM50041940 (6-Benzyl-5-methyl-thieno[2,3-d]pyrimidine-2,4-diam...) Show SMILES Cc1c(Cc2ccccc2)sc2nc(N)nc(N)c12 Show InChI InChI=1S/C14H14N4S/c1-8-10(7-9-5-3-2-4-6-9)19-13-11(8)12(15)17-14(16)18-13/h2-6H,7H2,1H3,(H4,15,16,17,18)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	640	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of dihydrofolate reductase in pneumocystis carinii.				J Med Chem 36: 3103-12 (1993) BindingDB Entry DOI: 10.7270/Q23X85PX
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Lactobacillus casei)	BDBM50041942 (5-Methyl-6-phenyl-thieno[2,3-d]pyrimidine-2,4-diam...) Show SMILES Cc1c(sc2nc(N)nc(N)c12)-c1ccccc1 Show InChI InChI=1S/C13H12N4S/c1-7-9-11(14)16-13(15)17-12(9)18-10(7)8-5-3-2-4-6-8/h2-6H,1H3,(H4,14,15,16,17)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	650	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Tested for inhibitory activity against dihydrofolate reductase in Beef liver				J Med Chem 36: 3103-12 (1993) BindingDB Entry DOI: 10.7270/Q23X85PX
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50041943 (6-(2,5-Dimethoxy-benzyl)-5-methyl-thieno[2,3-d]pyr...) Show SMILES COc1ccc(OC)c(Cc2sc3nc(N)nc(N)c3c2C)c1 Show InChI InChI=1S/C16H18N4O2S/c1-8-12(23-15-13(8)14(17)19-16(18)20-15)7-9-6-10(21-2)4-5-11(9)22-3/h4-6H,7H2,1-3H3,(H4,17,18,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	730	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Tested for inhibitory activity against dihydrofolate reductase in human				J Med Chem 36: 3103-12 (1993) BindingDB Entry DOI: 10.7270/Q23X85PX
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50041929 (6-(2,5-Dimethoxy-phenyl)-5-methyl-thieno[2,3-d]pyr...) Show SMILES COc1ccc(OC)c(c1)-c1sc2nc(N)nc(N)c2c1C Show InChI InChI=1S/C15H16N4O2S/c1-7-11-13(16)18-15(17)19-14(11)22-12(7)9-6-8(20-2)4-5-10(9)21-3/h4-6H,1-3H3,(H4,16,17,18,19)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	750	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Tested for inhibitory activity against dihydrofolate reductase in human				J Med Chem 36: 3103-12 (1993) BindingDB Entry DOI: 10.7270/Q23X85PX
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM50041928 (7-Benzyl-5,6,7,8-tetrahydro-9-thia-1,3,7-triaza-fl...) Show SMILES Nc1nc(N)c2c3CCN(Cc4ccccc4)Cc3sc2n1 Show InChI InChI=1S/C16H17N5S/c17-14-13-11-6-7-21(8-10-4-2-1-3-5-10)9-12(11)22-15(13)20-16(18)19-14/h1-5H,6-9H2,(H4,17,18,19,20)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	850	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Tested for inhibitory activity against dihydrofolate reductase in Toxoplasma gondii				J Med Chem 36: 3103-12 (1993) BindingDB Entry DOI: 10.7270/Q23X85PX
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Escherichia coli)	BDBM50041941 (6,7,8,9-Tetrahydro-5H-10-thia-1,3-diaza-benzo[a]az...) Show SMILES Nc1nc(N)c2c3CCCCCc3sc2n1 Show InChI InChI=1S/C11H14N4S/c12-9-8-6-4-2-1-3-5-7(6)16-10(8)15-11(13)14-9/h1-5H2,(H4,12,13,14,15)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	860	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of dihydrofolate reductase in Toxoplasma gondii.				J Med Chem 36: 3103-12 (1993) BindingDB Entry DOI: 10.7270/Q23X85PX
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Escherichia coli)	BDBM50029769 (6-[2-(2,5-Dimethoxy-phenyl)-ethyl]-5-methyl-thieno...) Show SMILES COc1ccc(OC)c(CCc2sc3nc(N)nc(N)c3c2C)c1 Show InChI InChI=1S/C17H20N4O2S/c1-9-13(24-16-14(9)15(18)20-17(19)21-16)7-4-10-8-11(22-2)5-6-12(10)23-3/h5-6,8H,4,7H2,1-3H3,(H4,18,19,20,21)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of dihydrofolate reductase in pneumocystis carinii.				J Med Chem 36: 3103-12 (1993) BindingDB Entry DOI: 10.7270/Q23X85PX
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Lactobacillus casei)	BDBM50041940 (6-Benzyl-5-methyl-thieno[2,3-d]pyrimidine-2,4-diam...) Show SMILES Cc1c(Cc2ccccc2)sc2nc(N)nc(N)c12 Show InChI InChI=1S/C14H14N4S/c1-8-10(7-9-5-3-2-4-6-9)19-13-11(8)12(15)17-14(16)18-13/h2-6H,7H2,1H3,(H4,15,16,17,18)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Tested for inhibitory activity against dihydrofolate reductase in L. casei				J Med Chem 36: 3103-12 (1993) BindingDB Entry DOI: 10.7270/Q23X85PX
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM50041941 (6,7,8,9-Tetrahydro-5H-10-thia-1,3-diaza-benzo[a]az...) Show SMILES Nc1nc(N)c2c3CCCCCc3sc2n1 Show InChI InChI=1S/C11H14N4S/c12-9-8-6-4-2-1-3-5-7(6)16-10(8)15-11(13)14-9/h1-5H2,(H4,12,13,14,15)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of rat liver dihydrofolate reductase.				J Med Chem 36: 3103-12 (1993) BindingDB Entry DOI: 10.7270/Q23X85PX
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Escherichia coli)	BDBM50041941 (6,7,8,9-Tetrahydro-5H-10-thia-1,3-diaza-benzo[a]az...) Show SMILES Nc1nc(N)c2c3CCCCCc3sc2n1 Show InChI InChI=1S/C11H14N4S/c12-9-8-6-4-2-1-3-5-7(6)16-10(8)15-11(13)14-9/h1-5H2,(H4,12,13,14,15)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of dihydrofolate reductase in pneumocystis carinii.				J Med Chem 36: 3103-12 (1993) BindingDB Entry DOI: 10.7270/Q23X85PX
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Lactobacillus casei)	BDBM50041942 (5-Methyl-6-phenyl-thieno[2,3-d]pyrimidine-2,4-diam...) Show SMILES Cc1c(sc2nc(N)nc(N)c12)-c1ccccc1 Show InChI InChI=1S/C13H12N4S/c1-7-9-11(14)16-13(15)17-12(9)18-10(7)8-5-3-2-4-6-8/h2-6H,1H3,(H4,14,15,16,17)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of dihydrofolate reductase in Toxoplasma gondii.				J Med Chem 36: 3103-12 (1993) BindingDB Entry DOI: 10.7270/Q23X85PX
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM50041939 (5-Methyl-6-(3,4,5-trimethoxy-phenyl)-thieno[2,3-d]...) Show SMILES COc1cc(cc(OC)c1OC)-c1sc2nc(N)nc(N)c2c1C Show InChI InChI=1S/C16H18N4O3S/c1-7-11-14(17)19-16(18)20-15(11)24-13(7)8-5-9(21-2)12(23-4)10(6-8)22-3/h5-6H,1-4H3,(H4,17,18,19,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of rat liver dihydrofolate reductase.				J Med Chem 36: 3103-12 (1993) BindingDB Entry DOI: 10.7270/Q23X85PX
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM50041935 (5,6,7,8,9,10-Hexahydro-11-thia-1,3-diaza-cycloocta...) Show SMILES Nc1nc(N)c2c3CCCCCCc3sc2n1 Show InChI InChI=1S/C12H16N4S/c13-10-9-7-5-3-1-2-4-6-8(7)17-11(9)16-12(14)15-10/h1-6H2,(H4,13,14,15,16)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of rat liver dihydrofolate reductase.				J Med Chem 36: 3103-12 (1993) BindingDB Entry DOI: 10.7270/Q23X85PX
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Lactobacillus casei)	BDBM50041936 (6-(3,4-Dichloro-phenyl)-5-methyl-thieno[2,3-d]pyri...) Show SMILES Cc1c(sc2nc(N)nc(N)c12)-c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C13H10Cl2N4S/c1-5-9-11(16)18-13(17)19-12(9)20-10(5)6-2-3-7(14)8(15)4-6/h2-4H,1H3,(H4,16,17,18,19)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of dihydrofolate reductase in pneumocystis carinii.				J Med Chem 36: 3103-12 (1993) BindingDB Entry DOI: 10.7270/Q23X85PX
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Escherichia coli)	BDBM50041932 (5,6,7,8-Tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidi...) Show SMILES Nc1nc(N)c2c3CCCCc3sc2n1 Show InChI InChI=1S/C10H12N4S/c11-8-7-5-3-1-2-4-6(5)15-9(7)14-10(12)13-8/h1-4H2,(H4,11,12,13,14)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of dihydrofolate reductase in pneumocystis carinii.				J Med Chem 36: 3103-12 (1993) BindingDB Entry DOI: 10.7270/Q23X85PX
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Escherichia coli)	BDBM50041932 (5,6,7,8-Tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidi...) Show SMILES Nc1nc(N)c2c3CCCCc3sc2n1 Show InChI InChI=1S/C10H12N4S/c11-8-7-5-3-1-2-4-6(5)15-9(7)14-10(12)13-8/h1-4H2,(H4,11,12,13,14)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of dihydrofolate reductase in Toxoplasma gondii.				J Med Chem 36: 3103-12 (1993) BindingDB Entry DOI: 10.7270/Q23X85PX
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM50041931 (5-[2-(2,5-Dimethoxy-phenyl)-ethyl]-thieno[2,3-d]py...) Show SMILES COc1ccc(OC)c(CCc2csc3nc(N)nc(N)c23)c1 Show InChI InChI=1S/C16H18N4O2S/c1-21-11-5-6-12(22-2)9(7-11)3-4-10-8-23-15-13(10)14(17)19-16(18)20-15/h5-8H,3-4H2,1-2H3,(H4,17,18,19,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	3.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of rat liver dihydrofolate reductase.				J Med Chem 36: 3103-12 (1993) BindingDB Entry DOI: 10.7270/Q23X85PX
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Escherichia coli)	BDBM50029769 (6-[2-(2,5-Dimethoxy-phenyl)-ethyl]-5-methyl-thieno...) Show SMILES COc1ccc(OC)c(CCc2sc3nc(N)nc(N)c3c2C)c1 Show InChI InChI=1S/C17H20N4O2S/c1-9-13(24-16-14(9)15(18)20-17(19)21-16)7-4-10-8-11(22-2)5-6-12(10)23-3/h5-6,8H,4,7H2,1-3H3,(H4,18,19,20,21)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	3.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of dihydrofolate reductase in pneumocystis carinii.				J Med Chem 36: 3103-12 (1993) BindingDB Entry DOI: 10.7270/Q23X85PX
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Escherichia coli)	BDBM50041942 (5-Methyl-6-phenyl-thieno[2,3-d]pyrimidine-2,4-diam...) Show SMILES Cc1c(sc2nc(N)nc(N)c12)-c1ccccc1 Show InChI InChI=1S/C13H12N4S/c1-7-9-11(14)16-13(15)17-12(9)18-10(7)8-5-3-2-4-6-8/h2-6H,1H3,(H4,14,15,16,17)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	3.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of dihydrofolate reductase in Toxoplasma gondii.				J Med Chem 36: 3103-12 (1993) BindingDB Entry DOI: 10.7270/Q23X85PX
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM50041932 (5,6,7,8-Tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidi...) Show SMILES Nc1nc(N)c2c3CCCCc3sc2n1 Show InChI InChI=1S/C10H12N4S/c11-8-7-5-3-1-2-4-6(5)15-9(7)14-10(12)13-8/h1-4H2,(H4,11,12,13,14)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	3.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of rat liver dihydrofolate reductase.				J Med Chem 36: 3103-12 (1993) BindingDB Entry DOI: 10.7270/Q23X85PX
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Lactobacillus casei)	BDBM50041936 (6-(3,4-Dichloro-phenyl)-5-methyl-thieno[2,3-d]pyri...) Show SMILES Cc1c(sc2nc(N)nc(N)c12)-c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C13H10Cl2N4S/c1-5-9-11(16)18-13(17)19-12(9)20-10(5)6-2-3-7(14)8(15)4-6/h2-4H,1H3,(H4,16,17,18,19)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	4.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Tested for inhibitory activity against dihydrofolate reductase in Beef liver				J Med Chem 36: 3103-12 (1993) BindingDB Entry DOI: 10.7270/Q23X85PX
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM50041936 (6-(3,4-Dichloro-phenyl)-5-methyl-thieno[2,3-d]pyri...) Show SMILES Cc1c(sc2nc(N)nc(N)c12)-c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C13H10Cl2N4S/c1-5-9-11(16)18-13(17)19-12(9)20-10(5)6-2-3-7(14)8(15)4-6/h2-4H,1H3,(H4,16,17,18,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	4.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of rat liver dihydrofolate reductase.				J Med Chem 36: 3103-12 (1993) BindingDB Entry DOI: 10.7270/Q23X85PX
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Escherichia coli)	BDBM50041929 (6-(2,5-Dimethoxy-phenyl)-5-methyl-thieno[2,3-d]pyr...) Show SMILES COc1ccc(OC)c(c1)-c1sc2nc(N)nc(N)c2c1C Show InChI InChI=1S/C15H16N4O2S/c1-7-11-13(16)18-15(17)19-14(11)22-12(7)9-6-8(20-2)4-5-10(9)21-3/h4-6H,1-3H3,(H4,16,17,18,19)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	4.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of dihydrofolate reductase in Toxoplasma gondii.				J Med Chem 36: 3103-12 (1993) BindingDB Entry DOI: 10.7270/Q23X85PX
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Pneumocystis carinii)	BDBM50041928 (7-Benzyl-5,6,7,8-tetrahydro-9-thia-1,3,7-triaza-fl...) Show SMILES Nc1nc(N)c2c3CCN(Cc4ccccc4)Cc3sc2n1 Show InChI InChI=1S/C16H17N5S/c17-14-13-11-6-7-21(8-10-4-2-1-3-5-10)9-12(11)22-15(13)20-16(18)19-14/h1-5H,6-9H2,(H4,17,18,19,20)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	5.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Tested for inhibitory activity against dihydrofolate reductase in pneumocystis carinii				J Med Chem 36: 3103-12 (1993) BindingDB Entry DOI: 10.7270/Q23X85PX
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Escherichia coli)	BDBM50041931 (5-[2-(2,5-Dimethoxy-phenyl)-ethyl]-thieno[2,3-d]py...) Show SMILES COc1ccc(OC)c(CCc2csc3nc(N)nc(N)c23)c1 Show InChI InChI=1S/C16H18N4O2S/c1-21-11-5-6-12(22-2)9(7-11)3-4-10-8-23-15-13(10)14(17)19-16(18)20-15/h5-8H,3-4H2,1-2H3,(H4,17,18,19,20)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	5.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of dihydrofolate reductase in Toxoplasma gondii.				J Med Chem 36: 3103-12 (1993) BindingDB Entry DOI: 10.7270/Q23X85PX
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM50029769 (6-[2-(2,5-Dimethoxy-phenyl)-ethyl]-5-methyl-thieno...) Show SMILES COc1ccc(OC)c(CCc2sc3nc(N)nc(N)c3c2C)c1 Show InChI InChI=1S/C17H20N4O2S/c1-9-13(24-16-14(9)15(18)20-17(19)21-16)7-4-10-8-11(22-2)5-6-12(10)23-3/h5-6,8H,4,7H2,1-3H3,(H4,18,19,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	5.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of rat liver dihydrofolate reductase.				J Med Chem 36: 3103-12 (1993) BindingDB Entry DOI: 10.7270/Q23X85PX
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Escherichia coli)	BDBM50041940 (6-Benzyl-5-methyl-thieno[2,3-d]pyrimidine-2,4-diam...) Show SMILES Cc1c(Cc2ccccc2)sc2nc(N)nc(N)c12 Show InChI InChI=1S/C14H14N4S/c1-8-10(7-9-5-3-2-4-6-9)19-13-11(8)12(15)17-14(16)18-13/h2-6H,7H2,1H3,(H4,15,16,17,18)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	6.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of dihydrofolate reductase in Toxoplasma gondii.				J Med Chem 36: 3103-12 (1993) BindingDB Entry DOI: 10.7270/Q23X85PX
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Escherichia coli)	BDBM50041935 (5,6,7,8,9,10-Hexahydro-11-thia-1,3-diaza-cycloocta...) Show SMILES Nc1nc(N)c2c3CCCCCCc3sc2n1 Show InChI InChI=1S/C12H16N4S/c13-10-9-7-5-3-1-2-4-6-8(7)17-11(9)16-12(14)15-10/h1-6H2,(H4,13,14,15,16)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	6.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of dihydrofolate reductase in pneumocystis carinii.				J Med Chem 36: 3103-12 (1993) BindingDB Entry DOI: 10.7270/Q23X85PX
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Lactobacillus casei)	BDBM50041930 (5-(4-Chloro-phenyl)-6-methyl-thieno[2,3-d]pyrimidi...) Show SMILES Cc1sc2nc(N)nc(N)c2c1-c1ccc(Cl)cc1 Show InChI InChI=1S/C13H11ClN4S/c1-6-9(7-2-4-8(14)5-3-7)10-11(15)17-13(16)18-12(10)19-6/h2-5H,1H3,(H4,15,16,17,18)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	7.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Tested for inhibitory activity against dihydrofolate reductase in L. casei				J Med Chem 36: 3103-12 (1993) BindingDB Entry DOI: 10.7270/Q23X85PX
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Escherichia coli)	BDBM50041939 (5-Methyl-6-(3,4,5-trimethoxy-phenyl)-thieno[2,3-d]...) Show SMILES COc1cc(cc(OC)c1OC)-c1sc2nc(N)nc(N)c2c1C Show InChI InChI=1S/C16H18N4O3S/c1-7-11-14(17)19-16(18)20-15(11)24-13(7)8-5-9(21-2)12(23-4)10(6-8)22-3/h5-6H,1-4H3,(H4,17,18,19,20)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>8.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Tested for inhibitory activity against dihydrofolate reductase in Beef liver				J Med Chem 36: 3103-12 (1993) BindingDB Entry DOI: 10.7270/Q23X85PX
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Escherichia coli)	BDBM50041934 (5-Methyl-6-(3,4,5-trimethoxy-benzyl)-thieno[2,3-d]...) Show SMILES COc1cc(Cc2sc3nc(N)nc(N)c3c2C)cc(OC)c1OC Show InChI InChI=1S/C17H20N4O3S/c1-8-12(25-16-13(8)15(18)20-17(19)21-16)7-9-5-10(22-2)14(24-4)11(6-9)23-3/h5-6H,7H2,1-4H3,(H4,18,19,20,21)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>8.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Tested for inhibitory activity against dihydrofolate reductase in Beef liver				J Med Chem 36: 3103-12 (1993) BindingDB Entry DOI: 10.7270/Q23X85PX
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Escherichia coli)	BDBM50041933 (5-Methyl-6-[2-(3,4,5-trimethoxy-phenyl)-ethyl]-thi...) Show SMILES COc1cc(CCc2sc3nc(N)nc(N)c3c2C)cc(OC)c1OC Show InChI InChI=1S/C18H22N4O3S/c1-9-13(26-17-14(9)16(19)21-18(20)22-17)6-5-10-7-11(23-2)15(25-4)12(8-10)24-3/h7-8H,5-6H2,1-4H3,(H4,19,20,21,22)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>8.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of dihydrofolate reductase in pneumocystis carinii.				J Med Chem 36: 3103-12 (1993) BindingDB Entry DOI: 10.7270/Q23X85PX
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM50041927 (5,6,7,8,9,10,11,12,13,14-Decahydro-15-thia-1,3-dia...) Show SMILES Nc1nc(N)c2c3CCCCCCCCCCc3sc2n1 Show InChI InChI=1S/C16H24N4S/c17-14-13-11-9-7-5-3-1-2-4-6-8-10-12(11)21-15(13)20-16(18)19-14/h1-10H2,(H4,17,18,19,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	9.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of rat liver dihydrofolate reductase.				J Med Chem 36: 3103-12 (1993) BindingDB Entry DOI: 10.7270/Q23X85PX
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50041939 (5-Methyl-6-(3,4,5-trimethoxy-phenyl)-thieno[2,3-d]...) Show SMILES COc1cc(cc(OC)c1OC)-c1sc2nc(N)nc(N)c2c1C Show InChI InChI=1S/C16H18N4O3S/c1-7-11-14(17)19-16(18)20-15(11)24-13(7)8-5-9(21-2)12(23-4)10(6-8)22-3/h5-6H,1-4H3,(H4,17,18,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Tested for inhibitory activity against dihydrofolate reductase in human				J Med Chem 36: 3103-12 (1993) BindingDB Entry DOI: 10.7270/Q23X85PX
					More data for this Ligand-Target Pair

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