BindingDB PrimarySearch

Found 6 hits Enz. Inhib. hit(s) with all data for entry = 50015634
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50158569 (2-S-[5-[2,4-diaminopteridin-6-yl)methyamino]-2,3-d...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.0340	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of human DHFR				J Med Chem 47: 6958-63 (2004) Article DOI: 10.1021/jm040122s BindingDB Entry DOI: 10.7270/Q2NZ873F
Harvard Medical School Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50158570 (2-R,S-[5-[(2,4-diaminopteridin-6-yl)methylamino]-2...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.0770	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of human DHFR				J Med Chem 47: 6958-63 (2004) Article DOI: 10.1021/jm040122s BindingDB Entry DOI: 10.7270/Q2NZ873F
Harvard Medical School Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50158571 (2-S-[5-[N-(2,4--diaminopteridin-6-yl)methyl)-N-met...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of human DHFR				J Med Chem 47: 6958-63 (2004) Article DOI: 10.1021/jm040122s BindingDB Entry DOI: 10.7270/Q2NZ873F
Harvard Medical School Curated by ChEMBL					More data for this Ligand-Target Pair
Reduced folate transporter (Homo sapiens (Human))	BDBM50158569 (2-S-[5-[2,4-diaminopteridin-6-yl)methyamino]-2,3-d...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	280	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of RFC-mediated [3H]MTX influx into human CCRF-CEM cells				J Med Chem 47: 6958-63 (2004) Article DOI: 10.1021/jm040122s BindingDB Entry DOI: 10.7270/Q2NZ873F
Harvard Medical School Curated by ChEMBL					More data for this Ligand-Target Pair
Reduced folate transporter (Homo sapiens (Human))	BDBM50158570 (2-R,S-[5-[(2,4-diaminopteridin-6-yl)methylamino]-2...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	530	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of RFC-mediated [3H]MTX influx into human CCRF-CEM cells				J Med Chem 47: 6958-63 (2004) Article DOI: 10.1021/jm040122s BindingDB Entry DOI: 10.7270/Q2NZ873F
Harvard Medical School Curated by ChEMBL					More data for this Ligand-Target Pair
Reduced folate transporter (Homo sapiens (Human))	BDBM50158571 (2-S-[5-[N-(2,4--diaminopteridin-6-yl)methyl)-N-met...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of RFC-mediated [3H]MTX influx into human CCRF-CEM cells				J Med Chem 47: 6958-63 (2004) Article DOI: 10.1021/jm040122s BindingDB Entry DOI: 10.7270/Q2NZ873F
Harvard Medical School Curated by ChEMBL					More data for this Ligand-Target Pair