Found 38 hits Enz. Inhib. hit(s) with all data for entry = 50025170 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50269976
(Aib-Val-Aib-Glu-lle-Gln-Leu-Nle-His-Gln-Arg-Ala-Ly...)Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)C(C)(C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r,wU:81.81,25.25,62.61,8.12,97.97,wD:16.21,92.93,72.72,55.55,106.106,4.4,44.44,29.34,(16.82,-7.68,;15.49,-6.94,;15.46,-5.4,;14.12,-4.66,;14.1,-3.13,;12.8,-2.32,;11.44,-3.04,;11.45,-4.59,;10.17,-2.17,;10.17,-.63,;11.5,.14,;11.51,1.68,;12.83,-.63,;8.95,-3.07,;7.59,-2.35,;7.59,-.8,;6.31,-3.21,;6.31,-4.76,;7.65,-5.53,;7.65,-7.06,;6.32,-7.84,;8.98,-7.84,;5.11,-2.32,;3.74,-3.06,;3.75,-4.6,;2.46,-2.19,;1.25,-3.09,;-.11,-2.37,;-.1,-.82,;-1.38,-3.23,;-1.38,-4.77,;-.05,-5.55,;-.05,-7.08,;-1.38,-7.86,;1.29,-7.86,;-2.59,-2.34,;-3.95,-3.07,;-3.94,-4.61,;-5.22,-2.2,;-4.41,-.9,;-6.06,-3.48,;-6.53,-1.45,;-6.57,.09,;-5.22,.85,;-7.96,.78,;-7.96,2.28,;-9.35,2.94,;-10.59,2.02,;-9.36,4.47,;-7.82,4.49,;-10.89,4.45,;-9.38,6.01,;-9.3,.01,;-9.31,-1.52,;-10.63,.79,;2.46,-.65,;3.8,.13,;1.13,.13,;1.11,1.67,;15.29,-2.34,;15.3,-.79,;16.65,-3.07,;17.87,-2.18,;17.87,-.63,;19.2,.14,;20.67,-.35,;21.59,.88,;20.7,2.14,;19.22,1.68,;19.15,-3.04,;19.16,-4.59,;20.51,-2.32,;21.72,-3.21,;21.73,-4.75,;23.05,-5.53,;23.05,-7.06,;21.73,-7.83,;24.4,-7.83,;23,-2.34,;23.01,-.79,;24.37,-3.07,;25.59,-2.18,;25.59,-.64,;26.92,.14,;26.93,1.68,;28.25,2.44,;28.25,3.97,;29.58,4.74,;26.93,4.74,;26.86,-3.05,;26.87,-4.59,;28.22,-2.32,;29.43,-3.21,;29.43,-4.76,;30.71,-2.35,;30.72,-.8,;32.08,-3.08,;33.29,-2.19,;33.3,-.64,;34.63,.13,;34.63,1.67,;35.96,2.44,;35.96,3.98,;34.58,-3.05,;34.58,-4.6,;35.93,-2.31,;37.28,-3.05,;37.31,-4.58,;38.65,-5.32,;38.67,-6.85,;40.01,-7.59,;41.33,-6.8,;42.67,-7.53,;41.29,-5.26,;39.95,-4.53,;38.59,-2.26,;39.93,-2.99,;38.56,-.72,)| Show InChI InChI=1S/C76H127N23O19/c1-13-15-19-46(90-68(113)53(34-39(3)4)94-66(111)50(27-30-56(79)102)92-70(115)59(41(7)14-2)97-67(112)51(28-31-57(103)104)96-73(118)76(11,12)99-71(116)58(40(5)6)98-72(117)75(9,10)83)64(109)95-54(36-44-37-84-38-86-44)69(114)91-49(26-29-55(78)101)65(110)89-48(21-18-33-85-74(81)82)62(107)87-42(8)61(106)88-47(20-16-17-32-77)63(108)93-52(60(80)105)35-43-22-24-45(100)25-23-43/h22-25,37-42,46-54,58-59,100H,13-21,26-36,77,83H2,1-12H3,(H2,78,101)(H2,79,102)(H2,80,105)(H,84,86)(H,87,107)(H,88,106)(H,89,110)(H,90,113)(H,91,114)(H,92,115)(H,93,108)(H,94,111)(H,95,109)(H,96,118)(H,97,112)(H,98,117)(H,99,116)(H,103,104)(H4,81,82,85)/t41-,42-,46-,47-,48-,49-,50-,51-,52-,53-,54-,58-,59-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.87 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]DPC-AJ1951 from PTH/PTH-related peptide receptor (unknown origin) expressed in HKRK-B28 cells |
Proc Natl Acad Sci U S A 104: 6846-51 (2007)
Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50269975
(Aib-Val-Aib-Glu-lle-Gln-Leu-Nle-His-Gln-Har-Ala-Ly...)Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)C(C)(C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r,wU:81.81,25.25,62.61,8.12,98.98,wD:16.21,93.94,72.72,55.55,107.107,4.4,44.44,29.34,(18.87,-52.12,;17.53,-51.38,;17.51,-49.85,;16.17,-49.1,;16.14,-47.57,;14.85,-46.76,;13.48,-47.48,;13.49,-49.03,;12.21,-46.62,;12.21,-45.07,;13.55,-44.3,;13.55,-42.76,;14.87,-45.07,;10.99,-47.51,;9.63,-46.79,;9.63,-45.24,;8.36,-47.66,;8.36,-49.2,;9.69,-49.97,;9.69,-51.5,;8.36,-52.28,;11.02,-52.28,;7.15,-46.77,;5.78,-47.5,;5.79,-49.05,;4.5,-46.63,;3.29,-47.53,;1.94,-46.81,;1.94,-45.26,;.66,-47.67,;.66,-49.22,;1.99,-49.99,;1.99,-51.52,;.67,-52.3,;3.33,-52.3,;-.55,-46.78,;-1.91,-47.51,;-1.9,-49.05,;-3.18,-46.64,;-2.37,-45.34,;-4.02,-47.92,;-4.49,-45.89,;-4.52,-44.35,;-3.18,-43.6,;-5.92,-43.66,;-5.92,-42.16,;-7.31,-41.5,;-8.55,-42.43,;-7.31,-39.97,;-5.78,-39.96,;-8.85,-39.99,;-7.34,-38.44,;-7.26,-44.43,;-7.27,-45.97,;-8.58,-43.65,;4.5,-45.09,;5.84,-44.32,;3.17,-44.32,;3.16,-42.77,;17.33,-46.78,;17.34,-45.23,;18.7,-47.51,;19.91,-46.62,;19.91,-45.08,;21.25,-44.3,;22.72,-44.8,;23.63,-43.56,;22.74,-42.3,;21.26,-42.76,;21.19,-47.49,;21.2,-49.03,;22.55,-46.76,;23.77,-47.65,;23.77,-49.19,;25.09,-49.97,;25.1,-51.5,;23.77,-52.27,;26.44,-52.27,;25.05,-46.78,;25.05,-45.24,;26.42,-47.51,;27.63,-46.62,;27.63,-45.08,;28.97,-44.31,;28.97,-42.77,;30.3,-42,;30.3,-40.47,;31.62,-39.7,;31.62,-38.17,;32.95,-40.47,;28.9,-47.49,;28.91,-49.04,;30.27,-46.77,;31.47,-47.66,;31.47,-49.2,;32.75,-46.79,;32.76,-45.24,;34.12,-47.52,;35.34,-46.63,;35.34,-45.09,;36.67,-44.31,;36.67,-42.77,;38,-42.01,;38,-40.47,;36.62,-47.5,;36.62,-49.04,;37.98,-46.76,;39.32,-47.49,;39.35,-49.03,;40.69,-49.76,;40.72,-51.29,;42.06,-52.03,;43.37,-51.24,;44.71,-51.97,;43.33,-49.7,;41.99,-48.97,;40.63,-46.7,;41.97,-47.43,;40.6,-45.17,)| Show InChI InChI=1S/C77H129N23O19/c1-13-15-20-47(91-69(114)54(35-40(3)4)95-67(112)51(28-31-57(80)103)93-71(116)60(42(7)14-2)98-68(113)52(29-32-58(104)105)97-74(119)77(11,12)100-72(117)59(41(5)6)99-73(118)76(9,10)84)65(110)96-55(37-45-38-85-39-87-45)70(115)92-50(27-30-56(79)102)66(111)90-48(22-17-19-34-86-75(82)83)63(108)88-43(8)62(107)89-49(21-16-18-33-78)64(109)94-53(61(81)106)36-44-23-25-46(101)26-24-44/h23-26,38-43,47-55,59-60,101H,13-22,27-37,78,84H2,1-12H3,(H2,79,102)(H2,80,103)(H2,81,106)(H,85,87)(H,88,108)(H,89,107)(H,90,111)(H,91,114)(H,92,115)(H,93,116)(H,94,109)(H,95,112)(H,96,110)(H,97,119)(H,98,113)(H,99,118)(H,100,117)(H,104,105)(H4,82,83,86)/t42-,43-,47-,48-,49-,50-,51-,52-,53-,54-,55-,59-,60-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]DPC-AJ1951 from PTH/PTH-related peptide receptor (unknown origin) expressed in HKRK-B28 cells |
Proc Natl Acad Sci U S A 104: 6846-51 (2007)
Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50269978
(Aib-Val-Aib-Glu-lle-Gln-Leu-Nle-His-Gln-Arg-Ala-Fl...)Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)C(C)(C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCNC(=O)c1ccccc1-c1c2ccc(O)cc2oc2cc(=O)ccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r,wU:62.61,8.12,81.81,97.97,25.25,wD:55.55,44.44,4.4,29.34,92.93,72.72,130.134,16.21,(17.08,-55.29,;15.74,-54.54,;15.72,-53,;14.37,-52.25,;14.35,-50.72,;13.05,-49.9,;11.68,-50.63,;11.69,-52.18,;10.41,-49.76,;10.41,-48.21,;11.75,-47.44,;11.75,-45.89,;13.08,-48.22,;9.18,-50.66,;7.82,-49.93,;7.82,-48.38,;6.54,-50.81,;6.54,-52.35,;7.88,-53.13,;7.88,-54.66,;6.54,-55.44,;9.21,-55.44,;5.33,-49.91,;3.96,-50.65,;3.97,-52.2,;2.68,-49.78,;1.46,-50.68,;.1,-49.96,;.11,-48.4,;-1.17,-50.82,;-1.17,-52.37,;.16,-53.14,;.16,-54.68,;-1.17,-55.47,;1.5,-55.47,;-2.39,-49.93,;-3.75,-50.66,;-3.74,-52.21,;-5.02,-49.78,;-4.21,-48.48,;-5.88,-51.07,;-6.33,-49.03,;-6.37,-47.49,;-5.03,-46.73,;-7.78,-46.8,;-7.77,-45.29,;-9.18,-44.63,;-10.4,-45.56,;-9.17,-43.1,;-7.63,-43.08,;-10.7,-43.12,;-9.19,-41.56,;-9.11,-47.57,;-9.14,-49.11,;-10.44,-46.79,;2.68,-48.23,;4.02,-47.46,;1.34,-47.45,;1.33,-45.91,;15.54,-49.93,;15.55,-48.38,;16.91,-50.66,;18.13,-49.76,;18.13,-48.22,;19.47,-47.44,;20.94,-47.94,;21.86,-46.7,;20.97,-45.43,;19.48,-45.89,;19.42,-50.64,;19.42,-52.19,;20.78,-49.91,;22,-50.8,;22,-52.35,;23.33,-53.12,;23.33,-54.66,;22,-55.44,;24.68,-55.43,;23.28,-49.93,;23.29,-48.38,;24.65,-50.66,;25.87,-49.77,;25.87,-48.22,;27.21,-47.45,;27.21,-45.9,;28.54,-45.13,;28.54,-43.6,;29.87,-42.83,;27.21,-42.83,;27.15,-50.64,;27.15,-52.19,;28.51,-49.91,;29.72,-50.81,;29.73,-52.35,;31.01,-49.93,;31.01,-48.38,;32.36,-50.66,;33.68,-49.87,;33.68,-48.34,;32.34,-47.58,;32.33,-46.04,;31,-45.28,;30.97,-43.74,;32.28,-42.95,;33.63,-43.7,;32.25,-41.42,;30.72,-41.45,;29.92,-40.13,;30.67,-38.78,;32.2,-38.76,;32.99,-40.08,;34.52,-40.06,;35.27,-38.71,;34.48,-37.39,;35.23,-36.05,;36.77,-36.03,;37.52,-34.69,;37.56,-37.34,;36.82,-38.69,;37.62,-40.01,;36.85,-41.36,;37.65,-42.68,;36.89,-44.03,;37.67,-45.35,;35.35,-44.05,;34.56,-42.72,;35.31,-41.38,;35.02,-50.64,;35.03,-52.17,;36.35,-49.86,;37.68,-50.62,;37.69,-52.15,;39.03,-52.92,;39.02,-54.45,;40.36,-55.21,;41.69,-54.44,;43.02,-55.2,;41.67,-52.89,;40.34,-52.14,;39.01,-49.84,;40.34,-50.6,;39,-48.31,)| Show InChI InChI=1S/C96H137N23O23/c1-13-15-23-62(110-88(136)69(42-49(3)4)114-86(134)66(35-38-74(98)124)112-90(138)78(51(7)14-2)117-87(135)67(36-39-75(125)126)116-93(141)96(11,12)119-91(139)77(50(5)6)118-92(140)95(9,10)102)84(132)115-70(44-54-47-103-48-106-54)89(137)111-65(34-37-73(97)123)85(133)109-64(25-20-41-105-94(100)101)82(130)107-52(8)80(128)108-63(83(131)113-68(79(99)127)43-53-26-28-55(120)29-27-53)24-18-19-40-104-81(129)59-22-17-16-21-58(59)76-60-32-30-56(121)45-71(60)142-72-46-57(122)31-33-61(72)76/h16-17,21-22,26-33,45-52,62-70,77-78,120-121H,13-15,18-20,23-25,34-44,102H2,1-12H3,(H2,97,123)(H2,98,124)(H2,99,127)(H,103,106)(H,104,129)(H,107,130)(H,108,128)(H,109,133)(H,110,136)(H,111,137)(H,112,138)(H,113,131)(H,114,134)(H,115,132)(H,116,141)(H,117,135)(H,118,140)(H,119,139)(H,125,126)(H4,100,101,105)/t51-,52-,62-,63-,64-,65-,66-,67-,68-,69-,70-,77-,78-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 13.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]DPC-AJ1951 from PTH/PTH-related peptide receptor (unknown origin) expressed in HKRK-B28 cells |
Proc Natl Acad Sci U S A 104: 6846-51 (2007)
Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50269976
(Aib-Val-Aib-Glu-lle-Gln-Leu-Nle-His-Gln-Arg-Ala-Ly...)Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)C(C)(C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r,wU:81.81,25.25,62.61,8.12,97.97,wD:16.21,92.93,72.72,55.55,106.106,4.4,44.44,29.34,(16.82,-7.68,;15.49,-6.94,;15.46,-5.4,;14.12,-4.66,;14.1,-3.13,;12.8,-2.32,;11.44,-3.04,;11.45,-4.59,;10.17,-2.17,;10.17,-.63,;11.5,.14,;11.51,1.68,;12.83,-.63,;8.95,-3.07,;7.59,-2.35,;7.59,-.8,;6.31,-3.21,;6.31,-4.76,;7.65,-5.53,;7.65,-7.06,;6.32,-7.84,;8.98,-7.84,;5.11,-2.32,;3.74,-3.06,;3.75,-4.6,;2.46,-2.19,;1.25,-3.09,;-.11,-2.37,;-.1,-.82,;-1.38,-3.23,;-1.38,-4.77,;-.05,-5.55,;-.05,-7.08,;-1.38,-7.86,;1.29,-7.86,;-2.59,-2.34,;-3.95,-3.07,;-3.94,-4.61,;-5.22,-2.2,;-4.41,-.9,;-6.06,-3.48,;-6.53,-1.45,;-6.57,.09,;-5.22,.85,;-7.96,.78,;-7.96,2.28,;-9.35,2.94,;-10.59,2.02,;-9.36,4.47,;-7.82,4.49,;-10.89,4.45,;-9.38,6.01,;-9.3,.01,;-9.31,-1.52,;-10.63,.79,;2.46,-.65,;3.8,.13,;1.13,.13,;1.11,1.67,;15.29,-2.34,;15.3,-.79,;16.65,-3.07,;17.87,-2.18,;17.87,-.63,;19.2,.14,;20.67,-.35,;21.59,.88,;20.7,2.14,;19.22,1.68,;19.15,-3.04,;19.16,-4.59,;20.51,-2.32,;21.72,-3.21,;21.73,-4.75,;23.05,-5.53,;23.05,-7.06,;21.73,-7.83,;24.4,-7.83,;23,-2.34,;23.01,-.79,;24.37,-3.07,;25.59,-2.18,;25.59,-.64,;26.92,.14,;26.93,1.68,;28.25,2.44,;28.25,3.97,;29.58,4.74,;26.93,4.74,;26.86,-3.05,;26.87,-4.59,;28.22,-2.32,;29.43,-3.21,;29.43,-4.76,;30.71,-2.35,;30.72,-.8,;32.08,-3.08,;33.29,-2.19,;33.3,-.64,;34.63,.13,;34.63,1.67,;35.96,2.44,;35.96,3.98,;34.58,-3.05,;34.58,-4.6,;35.93,-2.31,;37.28,-3.05,;37.31,-4.58,;38.65,-5.32,;38.67,-6.85,;40.01,-7.59,;41.33,-6.8,;42.67,-7.53,;41.29,-5.26,;39.95,-4.53,;38.59,-2.26,;39.93,-2.99,;38.56,-.72,)| Show InChI InChI=1S/C76H127N23O19/c1-13-15-19-46(90-68(113)53(34-39(3)4)94-66(111)50(27-30-56(79)102)92-70(115)59(41(7)14-2)97-67(112)51(28-31-57(103)104)96-73(118)76(11,12)99-71(116)58(40(5)6)98-72(117)75(9,10)83)64(109)95-54(36-44-37-84-38-86-44)69(114)91-49(26-29-55(78)101)65(110)89-48(21-18-33-85-74(81)82)62(107)87-42(8)61(106)88-47(20-16-17-32-77)63(108)93-52(60(80)105)35-43-22-24-45(100)25-23-43/h22-25,37-42,46-54,58-59,100H,13-21,26-36,77,83H2,1-12H3,(H2,78,101)(H2,79,102)(H2,80,105)(H,84,86)(H,87,107)(H,88,106)(H,89,110)(H,90,113)(H,91,114)(H,92,115)(H,93,108)(H,94,111)(H,95,109)(H,96,118)(H,97,112)(H,98,117)(H,99,116)(H,103,104)(H4,81,82,85)/t41-,42-,46-,47-,48-,49-,50-,51-,52-,53-,54-,58-,59-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 55.4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]DPC-AJ1951 from PTH/PTH-related peptide receptor (unknown origin) expressed in HKRK-B28 cells in presence of SW106 |
Proc Natl Acad Sci U S A 104: 6846-51 (2007)
Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50269977
(Aib-Val-Aib-Glu-lle-Gln-Leu-Nle-His-Gln-Arg-Ala-Ly...)Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)C(C)(C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCNC(=O)c1ccccc1-c1c2ccc(O)cc2oc2cc(=O)ccc12)C(N)=O |r,wU:62.61,8.12,97.97,81.81,25.25,118.119,wD:55.55,106.106,4.4,44.44,29.34,16.21,92.93,72.72,(16.67,-31.38,;15.33,-30.63,;15.31,-29.09,;13.97,-28.35,;13.94,-26.81,;12.64,-26,;11.27,-26.72,;11.28,-28.28,;10,-25.85,;10,-24.31,;11.34,-23.53,;11.34,-21.99,;12.67,-24.31,;8.78,-26.75,;7.41,-26.03,;7.42,-24.48,;6.13,-26.9,;6.14,-28.44,;7.47,-29.22,;7.47,-30.76,;6.14,-31.53,;8.8,-31.53,;4.92,-26,;3.55,-26.74,;3.56,-28.29,;2.27,-25.87,;1.05,-26.77,;-.3,-26.05,;-.3,-24.49,;-1.58,-26.92,;-1.58,-28.46,;-.25,-29.24,;-.25,-30.77,;-1.58,-31.56,;1.09,-31.56,;-2.8,-26.02,;-4.15,-26.75,;-4.15,-28.3,;-5.43,-25.88,;-4.62,-24.58,;-6.27,-27.16,;-6.75,-25.13,;-6.78,-23.59,;-5.43,-22.83,;-8.17,-22.89,;-8.18,-21.39,;-9.57,-20.73,;-10.82,-21.65,;-9.58,-19.19,;-8.04,-19.18,;-11.11,-19.21,;-9.6,-17.65,;-9.53,-23.66,;-9.53,-25.2,;-10.85,-22.88,;2.27,-24.33,;3.61,-23.55,;.93,-23.55,;.92,-22,;15.13,-26.02,;15.15,-24.47,;16.5,-26.75,;17.72,-25.86,;17.72,-24.31,;19.06,-23.53,;20.53,-24.03,;21.45,-22.79,;20.56,-21.53,;19.07,-21.99,;19.01,-26.73,;19.01,-28.28,;20.37,-26,;21.59,-26.89,;21.59,-28.44,;22.92,-29.21,;22.92,-30.75,;21.59,-31.53,;24.27,-31.53,;22.87,-26.02,;22.88,-24.47,;24.24,-26.75,;25.46,-25.86,;25.46,-24.31,;26.8,-23.54,;26.8,-21.99,;28.13,-21.23,;28.13,-19.69,;29.46,-18.92,;26.8,-18.92,;26.74,-26.73,;26.74,-28.28,;28.1,-26,;29.31,-26.9,;29.31,-28.44,;30.6,-26.03,;30.6,-24.48,;31.97,-26.76,;33.19,-25.87,;33.19,-24.32,;34.53,-23.54,;34.53,-22,;35.86,-21.23,;35.86,-19.69,;34.47,-26.74,;34.48,-28.29,;35.83,-26,;37.18,-26.73,;37.21,-28.27,;38.56,-29.01,;38.58,-30.54,;39.93,-31.28,;41.24,-30.49,;42.59,-31.23,;41.2,-28.95,;39.86,-28.21,;38.49,-25.94,;38.46,-24.4,;39.84,-26.67,;41.16,-25.89,;41.15,-24.36,;39.82,-23.6,;39.81,-22.06,;38.48,-21.3,;38.45,-19.76,;39.76,-18.97,;41.1,-19.72,;39.72,-17.44,;38.19,-17.47,;37.4,-16.15,;38.14,-14.8,;39.68,-14.78,;40.47,-16.1,;41.99,-16.08,;42.74,-14.73,;41.96,-13.41,;42.71,-12.07,;44.25,-12.05,;44.99,-10.71,;45.04,-13.36,;44.3,-14.71,;45.1,-16.03,;44.33,-17.38,;45.12,-18.7,;44.36,-20.05,;45.15,-21.37,;42.82,-20.07,;42.04,-18.74,;42.79,-17.4,;42.5,-26.65,;42.51,-28.19,;43.83,-25.88,)| Show InChI InChI=1S/C102H149N25O24/c1-13-15-25-67(118-93(144)73(46-53(3)4)121-91(142)71(38-41-79(105)132)120-96(147)83(55(7)14-2)125-92(143)72(39-42-80(133)134)124-99(150)102(11,12)127-97(148)82(54(5)6)126-98(149)101(9,10)109)88(139)123-75(48-58-51-110-52-113-58)95(146)119-70(37-40-78(104)131)90(141)117-69(28-22-45-112-100(107)108)87(138)114-56(8)85(136)116-68(27-18-20-43-103)89(140)122-74(47-57-29-31-59(128)32-30-57)94(145)115-66(84(106)135)26-19-21-44-111-86(137)63-24-17-16-23-62(63)81-64-35-33-60(129)49-76(64)151-77-50-61(130)34-36-65(77)81/h16-17,23-24,29-36,49-56,66-75,82-83,128-129H,13-15,18-22,25-28,37-48,103,109H2,1-12H3,(H2,104,131)(H2,105,132)(H2,106,135)(H,110,113)(H,111,137)(H,114,138)(H,115,145)(H,116,136)(H,117,141)(H,118,144)(H,119,146)(H,120,147)(H,121,142)(H,122,140)(H,123,139)(H,124,150)(H,125,143)(H,126,149)(H,127,148)(H,133,134)(H4,107,108,112)/t55-,56-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,82-,83-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 98.2 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]DPC-AJ1951 from PTH/PTH-related peptide receptor (unknown origin) expressed in HKRK-B28 cells |
Proc Natl Acad Sci U S A 104: 6846-51 (2007)
Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50269979
(CHEMBL515170 | r-5-(2-E-cyclopropylvinyl)-t-3-ethy...)Show SMILES CC[C@@H]1O[C@@](\C=C\C2CC2)(c2c(F)c(F)ccc2NC1=O)C(F)(F)F |r| Show InChI InChI=1S/C17H16F5NO2/c1-2-12-15(24)23-11-6-5-10(18)14(19)13(11)16(25-12,17(20,21)22)8-7-9-3-4-9/h5-9,12H,2-4H2,1H3,(H,23,24)/b8-7+/t12-,16-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 990 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]DPC-AJ1951 from PTH/PTH-related peptide receptor (unknown origin) expressed in HKRK-B28 cells |
Proc Natl Acad Sci U S A 104: 6846-51 (2007)
Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50269973
(Ala-Val-Ala-Glu-lle-Gln-Leu-Nle-His-Gln-Har-Ala-Ly...)Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r,wU:96.96,47.48,25.25,79.79,8.12,60.59,38.38,119.121,wD:16.21,91.92,53.53,43.43,70.70,4.4,105.105,29.34,(16.87,-8.93,;15.54,-8.19,;15.51,-6.66,;14.17,-5.91,;14.15,-4.38,;12.85,-3.57,;11.49,-4.29,;11.5,-5.84,;10.22,-3.42,;10.22,-1.88,;11.55,-1.11,;11.56,.43,;12.88,-1.88,;9,-4.32,;7.64,-3.6,;7.64,-2.05,;6.36,-4.47,;6.37,-6.01,;7.7,-6.78,;7.7,-8.31,;6.37,-9.09,;9.03,-9.09,;5.16,-3.57,;3.79,-4.31,;3.8,-5.86,;2.51,-3.44,;1.3,-4.34,;-.05,-3.62,;-.05,-2.07,;-1.33,-4.48,;-1.33,-6.02,;0,-6.8,;0,-8.33,;-1.32,-9.11,;1.34,-9.11,;-2.54,-3.59,;-3.9,-4.32,;-3.89,-5.86,;-5.17,-3.45,;-5.17,-1.91,;-6.39,-4.33,;-7.74,-3.6,;-7.74,-2.06,;-9.03,-4.47,;-10.24,-3.58,;-11.6,-4.31,;-11.59,-5.85,;-12.89,-3.44,;-12.89,-1.9,;-14.09,-4.33,;-9.03,-6.02,;-7.7,-6.79,;-10.36,-6.79,;2.51,-1.9,;3.85,-1.13,;1.18,-1.12,;1.16,.42,;15.34,-3.59,;15.35,-2.04,;16.7,-4.32,;17.92,-3.43,;17.92,-1.89,;19.25,-1.11,;20.72,-1.6,;21.63,-.37,;20.75,.89,;19.27,.43,;19.2,-4.3,;19.21,-5.84,;20.56,-3.57,;21.77,-4.46,;21.77,-6,;23.1,-6.78,;23.1,-8.31,;21.78,-9.08,;24.45,-9.08,;23.05,-3.59,;23.06,-2.05,;24.42,-4.32,;25.64,-3.43,;25.64,-1.89,;26.97,-1.11,;26.97,.43,;28.3,1.19,;28.3,2.72,;29.63,3.49,;29.63,5.02,;30.95,2.72,;26.91,-4.3,;26.92,-5.84,;28.27,-3.57,;29.48,-4.47,;29.48,-6.01,;30.76,-3.6,;30.77,-2.05,;32.13,-4.33,;33.34,-3.44,;33.34,-1.89,;34.68,-1.12,;34.68,.42,;36.01,1.18,;36.01,2.72,;34.62,-4.3,;34.63,-5.85,;35.98,-3.57,;37.2,-4.46,;37.21,-6,;38.53,-6.78,;40.03,-6.44,;40.82,-7.75,;39.8,-8.91,;40,-10.44,;38.76,-11.36,;37.35,-10.75,;37.16,-9.24,;38.4,-8.3,;38.48,-3.59,;38.48,-2.04,;39.83,-4.31,;41.13,-3.51,;41.08,-1.97,;42.38,-1.17,;43.73,-1.9,;45.03,-1.09,;44.98,.44,;46.28,1.25,;43.62,1.16,;42.33,.35,;42.48,-4.23,;43.79,-3.42,;42.53,-5.76,)| Show InChI InChI=1S/C86H135N25O20/c1-11-13-21-56(103-81(127)63(37-44(3)4)107-79(125)60(30-33-67(90)114)105-85(131)70(46(7)12-2)111-80(126)61(31-34-68(115)116)101-74(120)49(10)99-84(130)69(45(5)6)110-72(118)47(8)88)76(122)109-65(40-52-42-94-43-97-52)83(129)104-59(29-32-66(89)113)78(124)102-57(24-17-19-36-95-86(92)93)75(121)98-48(9)73(119)100-58(23-16-18-35-87)77(123)108-64(39-51-41-96-55-22-15-14-20-54(51)55)82(128)106-62(71(91)117)38-50-25-27-53(112)28-26-50/h14-15,20,22,25-28,41-49,56-65,69-70,96,112H,11-13,16-19,21,23-24,29-40,87-88H2,1-10H3,(H2,89,113)(H2,90,114)(H2,91,117)(H,94,97)(H,98,121)(H,99,130)(H,100,119)(H,101,120)(H,102,124)(H,103,127)(H,104,129)(H,105,131)(H,106,128)(H,107,125)(H,108,123)(H,109,122)(H,110,118)(H,111,126)(H,115,116)(H4,92,93,95)/t46-,47-,48-,49-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,69-,70-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.19E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]DPC-AJ1951 from PTH/PTH-related peptide receptor (unknown origin) expressed in HKRK-B28 cells |
Proc Natl Acad Sci U S A 104: 6846-51 (2007)
Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50269979
(CHEMBL515170 | r-5-(2-E-cyclopropylvinyl)-t-3-ethy...)Show SMILES CC[C@@H]1O[C@@](\C=C\C2CC2)(c2c(F)c(F)ccc2NC1=O)C(F)(F)F |r| Show InChI InChI=1S/C17H16F5NO2/c1-2-12-15(24)23-11-6-5-10(18)14(19)13(11)16(25-12,17(20,21)22)8-7-9-3-4-9/h5-9,12H,2-4H2,1H3,(H,23,24)/b8-7+/t12-,16-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.78E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Antagonist activity at PTH/PTH-related peptide receptor (unknown origin) expressed in HKRK-B28 cells assessed as inhibition of DPC-AJ1951-induced cAM... |
Proc Natl Acad Sci U S A 104: 6846-51 (2007)
Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50269972
(Ala-Val-Ala-Glu-lle-Gln-Leu-Met-His-Gln-Har-Ala-Ly...)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1ccccc1-c1c2ccc(O)cc2oc2cc(=O)ccc12)C(N)=O |r,wU:4.4,44.43,60.59,79.79,26.27,96.96,17.17,119.121,wD:105.105,2.2,35.34,52.51,91.92,22.22,70.70,8.13,(4.06,-29.82,;4.08,-31.37,;5.42,-32.14,;6.75,-31.37,;5.42,-33.68,;4.2,-34.58,;2.86,-33.87,;2.86,-32.31,;1.59,-34.73,;1.59,-36.27,;2.91,-37.04,;2.91,-38.57,;1.59,-39.36,;4.24,-39.35,;.37,-33.83,;-.98,-34.56,;-.98,-36.11,;-2.26,-33.69,;-2.26,-32.15,;-3.5,-34.58,;-4.83,-33.85,;-4.82,-32.3,;-6.12,-34.72,;-7.33,-33.82,;-8.68,-34.55,;-8.68,-36.1,;-9.96,-33.68,;-9.96,-32.14,;-11.17,-34.57,;-6.12,-36.27,;-4.78,-37.03,;-7.44,-37.03,;6.7,-34.55,;6.7,-36.1,;8.06,-33.82,;9.27,-34.71,;9.27,-36.25,;10.61,-37.02,;10.61,-38.56,;9.27,-39.33,;11.93,-39.33,;10.54,-33.84,;10.55,-32.29,;11.91,-34.57,;13.13,-33.67,;13.13,-32.13,;14.46,-31.35,;14.46,-29.81,;15.79,-32.13,;14.4,-34.54,;14.4,-36.08,;15.76,-33.81,;16.96,-34.7,;16.96,-36.24,;18.3,-37.02,;18.3,-38.55,;19.63,-39.32,;18.24,-33.83,;18.26,-32.29,;19.61,-34.56,;20.83,-33.67,;20.83,-32.13,;22.16,-31.35,;23.63,-31.85,;24.54,-30.61,;23.65,-29.35,;22.18,-29.81,;22.11,-34.54,;22.11,-36.09,;23.46,-33.81,;24.68,-34.7,;24.68,-36.25,;26.01,-37.02,;26.01,-38.55,;24.68,-39.33,;27.35,-39.32,;25.96,-33.84,;25.97,-32.29,;27.33,-34.57,;28.54,-33.67,;28.55,-32.13,;29.88,-31.36,;29.88,-29.82,;31.21,-29.05,;31.21,-27.52,;32.54,-26.76,;32.54,-25.23,;33.86,-27.52,;29.82,-34.54,;29.82,-36.09,;31.18,-33.82,;32.39,-34.71,;32.39,-36.25,;33.67,-33.84,;33.67,-32.29,;35.03,-34.57,;36.25,-33.68,;36.25,-32.14,;37.59,-31.36,;37.59,-29.82,;38.91,-29.06,;38.91,-27.52,;37.53,-34.55,;37.54,-36.09,;38.89,-33.81,;40.11,-34.7,;40.11,-36.24,;41.44,-37.02,;42.94,-36.68,;43.73,-37.99,;42.71,-39.16,;42.9,-40.68,;41.67,-41.6,;40.25,-41,;40.07,-39.48,;41.3,-38.55,;41.38,-33.83,;41.39,-32.29,;42.74,-34.56,;44.06,-33.78,;44.05,-32.25,;42.72,-31.49,;42.71,-29.96,;41.38,-29.2,;41.36,-27.67,;42.66,-26.88,;44,-27.62,;42.63,-25.35,;41.1,-25.38,;40.3,-24.07,;41.05,-22.73,;42.58,-22.7,;43.37,-24.02,;44.89,-24,;45.64,-22.65,;44.85,-21.34,;45.6,-20,;47.14,-19.98,;47.88,-18.64,;47.92,-21.28,;47.19,-22.63,;47.98,-23.95,;47.22,-25.3,;48.01,-26.61,;47.25,-27.95,;48.03,-29.27,;45.72,-27.97,;44.93,-26.65,;45.68,-25.32,;45.39,-34.54,;45.4,-36.07,;46.72,-33.77,)| Show InChI InChI=1S/C102H146N26O23S/c1-11-54(6)85(128-96(145)73(35-38-82(133)134)119-89(138)57(9)116-100(149)84(53(4)5)127-87(136)55(7)104)101(150)123-72(34-37-81(106)132)94(143)124-75(44-52(2)3)97(146)122-74(39-43-152-10)95(144)126-77(46-59-50-110-51-114-59)99(148)121-71(33-36-80(105)131)93(142)120-69(28-18-21-42-112-102(108)109)91(140)115-56(8)88(137)118-70(27-16-19-40-103)92(141)125-76(45-58-49-113-67-25-15-14-22-62(58)67)98(147)117-68(86(107)135)26-17-20-41-111-90(139)64-24-13-12-23-63(64)83-65-31-29-60(129)47-78(65)151-79-48-61(130)30-32-66(79)83/h12-15,22-25,29-32,47-57,68-77,84-85,113,129H,11,16-21,26-28,33-46,103-104H2,1-10H3,(H2,105,131)(H2,106,132)(H2,107,135)(H,110,114)(H,111,139)(H,115,140)(H,116,149)(H,117,147)(H,118,137)(H,119,138)(H,120,142)(H,121,148)(H,122,146)(H,123,150)(H,124,143)(H,125,141)(H,126,144)(H,127,136)(H,128,145)(H,133,134)(H4,108,109,112)/t54-,55-,56-,57-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,84-,85-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.01E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]DPC-AJ1951 from PTH/PTH-related peptide receptor (unknown origin) expressed in HKRK-B28 cells |
Proc Natl Acad Sci U S A 104: 6846-51 (2007)
Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V |
More data for this
Ligand-Target Pair | |
Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50269979
(CHEMBL515170 | r-5-(2-E-cyclopropylvinyl)-t-3-ethy...)Show SMILES CC[C@@H]1O[C@@](\C=C\C2CC2)(c2c(F)c(F)ccc2NC1=O)C(F)(F)F |r| Show InChI InChI=1S/C17H16F5NO2/c1-2-12-15(24)23-11-6-5-10(18)14(19)13(11)16(25-12,17(20,21)22)8-7-9-3-4-9/h5-9,12H,2-4H2,1H3,(H,23,24)/b8-7+/t12-,16-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.04E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of adrenergic alpha2C receptor (unknown origin) |
Proc Natl Acad Sci U S A 104: 6846-51 (2007)
Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50269971
(Ala-Val-Ala-Glu-lle-Gln-Leu-Met-His-Gln-Har-Ala-Ly...)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O |r,wU:26.27,96.96,17.17,4.4,44.43,60.59,79.79,wD:70.70,8.13,105.105,2.2,35.34,52.51,91.92,22.22,(5.02,-.01,;5.03,-1.56,;6.37,-2.33,;7.7,-1.56,;6.37,-3.87,;5.16,-4.77,;3.8,-4.05,;3.81,-2.5,;2.53,-4.91,;2.53,-6.45,;3.86,-7.22,;3.86,-8.75,;2.53,-9.53,;5.19,-9.53,;1.32,-4.02,;-.03,-4.74,;-.03,-6.29,;-1.3,-3.88,;-1.3,-2.34,;-2.53,-4.76,;-3.88,-4.03,;-3.87,-2.49,;-5.16,-4.9,;-6.37,-4.01,;-7.72,-4.74,;-7.72,-6.28,;-9,-3.87,;-9,-2.33,;-10.21,-4.76,;-5.16,-6.45,;-3.83,-7.21,;-6.49,-7.21,;7.64,-4.74,;7.65,-6.28,;9.01,-4,;10.21,-4.89,;10.22,-6.43,;11.55,-7.21,;11.55,-8.74,;10.22,-9.51,;12.87,-9.51,;11.49,-4.03,;11.49,-2.48,;12.85,-4.75,;14.06,-3.85,;14.06,-2.31,;15.4,-1.54,;15.4,-0,;16.72,-2.31,;15.33,-4.72,;15.34,-6.26,;16.7,-4,;17.9,-4.88,;17.9,-6.42,;19.23,-7.2,;19.23,-8.73,;20.56,-9.5,;19.18,-4.02,;19.19,-2.47,;20.54,-4.75,;21.76,-3.86,;21.76,-2.32,;23.09,-1.54,;24.56,-2.04,;25.47,-.8,;24.58,.46,;23.1,-0,;23.03,-4.72,;23.04,-6.27,;24.39,-4,;25.61,-4.89,;25.61,-6.43,;26.93,-7.2,;26.93,-8.73,;25.61,-9.5,;28.27,-9.5,;26.88,-4.02,;26.89,-2.48,;28.25,-4.75,;29.46,-3.86,;29.47,-2.32,;30.8,-1.55,;30.8,-.01,;32.12,.76,;32.12,2.28,;33.45,3.05,;33.45,4.58,;34.77,2.28,;30.74,-4.73,;30.74,-6.27,;32.1,-4,;33.3,-4.89,;33.3,-6.43,;34.58,-4.03,;34.59,-2.48,;35.95,-4.76,;37.16,-3.86,;37.16,-2.32,;38.5,-1.55,;38.5,-.01,;39.82,.75,;39.82,2.29,;38.44,-4.73,;38.45,-6.28,;39.79,-3.99,;41.02,-4.88,;41.02,-6.42,;42.34,-7.2,;43.84,-6.86,;44.63,-8.17,;43.61,-9.33,;43.81,-10.86,;42.58,-11.78,;41.16,-11.17,;40.98,-9.66,;42.21,-8.73,;42.29,-4.02,;43.64,-4.74,;42.29,-2.47,)| Show InChI InChI=1S/C76H124N24O18S/c1-11-40(6)61(100-71(114)52(24-27-59(103)104)91-65(108)43(9)89-74(117)60(39(4)5)99-63(106)41(7)78)75(118)95-51(23-26-58(80)102)69(112)97-55(32-38(2)3)72(115)94-53(28-31-119-10)70(113)98-56(34-45-36-84-37-87-45)73(116)93-50(22-25-57(79)101)68(111)92-48(21-15-17-30-85-76(82)83)66(109)88-42(8)64(107)90-49(20-14-16-29-77)67(110)96-54(62(81)105)33-44-35-86-47-19-13-12-18-46(44)47/h12-13,18-19,35-43,48-56,60-61,86H,11,14-17,20-34,77-78H2,1-10H3,(H2,79,101)(H2,80,102)(H2,81,105)(H,84,87)(H,88,109)(H,89,117)(H,90,107)(H,91,108)(H,92,111)(H,93,116)(H,94,115)(H,95,118)(H,96,110)(H,97,112)(H,98,113)(H,99,106)(H,100,114)(H,103,104)(H4,82,83,85)/t40-,41-,42-,43-,48-,49-,50-,51-,52-,53-,54-,55-,56-,60-,61-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.05E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]DPC-AJ1951 from PTH/PTH-related peptide receptor (unknown origin) expressed in HKRK-B28 cells |
Proc Natl Acad Sci U S A 104: 6846-51 (2007)
Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50269974
(Ala-Val-Ala-Glu-lle-Gln-Leu-Nle-His-Gln-Har-Ala-Ly...)Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r,wU:79.79,25.25,47.48,60.59,8.12,38.38,96.96,wD:29.34,16.21,91.92,70.70,53.53,105.105,43.43,4.4,(19.79,-32.24,;18.45,-31.5,;18.43,-29.97,;17.09,-29.22,;17.07,-27.69,;15.77,-26.88,;14.41,-27.6,;14.41,-29.15,;13.14,-26.73,;13.14,-25.19,;14.47,-24.42,;14.47,-22.88,;15.8,-25.19,;11.92,-27.63,;10.55,-26.91,;10.56,-25.36,;9.28,-27.78,;9.28,-29.32,;10.62,-30.09,;10.62,-31.62,;9.28,-32.4,;11.94,-32.4,;8.07,-26.88,;6.71,-27.62,;6.71,-29.17,;5.43,-26.75,;4.22,-27.65,;2.86,-26.93,;2.87,-25.38,;1.59,-27.79,;1.59,-29.33,;2.92,-30.11,;2.92,-31.64,;1.59,-32.42,;4.25,-32.42,;.38,-26.9,;-.98,-27.63,;-.97,-29.17,;-2.25,-26.76,;-2.25,-25.22,;-3.47,-27.64,;-4.82,-26.91,;-4.82,-25.37,;-6.11,-27.78,;-7.32,-26.89,;-8.68,-27.62,;-8.67,-29.16,;-9.96,-26.75,;-9.96,-25.21,;-11.17,-27.64,;-6.11,-29.33,;-4.78,-30.1,;-7.44,-30.1,;5.43,-25.21,;6.76,-24.44,;4.09,-24.43,;4.08,-22.89,;18.25,-26.9,;18.27,-25.35,;19.62,-27.63,;20.84,-26.74,;20.84,-25.2,;22.17,-24.42,;23.64,-24.92,;24.55,-23.68,;23.66,-22.42,;22.19,-22.88,;22.12,-27.61,;22.12,-29.15,;23.47,-26.88,;24.69,-27.77,;24.69,-29.31,;26.02,-30.09,;26.02,-31.62,;24.69,-32.39,;27.36,-32.39,;25.97,-26.9,;25.98,-25.36,;27.34,-27.63,;28.55,-26.74,;28.55,-25.2,;29.89,-24.43,;29.89,-22.89,;31.22,-22.12,;31.22,-20.59,;32.54,-19.82,;32.54,-18.29,;33.87,-20.59,;29.83,-27.61,;29.83,-29.15,;31.19,-26.88,;32.4,-27.78,;32.4,-29.32,;33.68,-26.91,;33.68,-25.36,;35.04,-27.64,;36.26,-26.75,;36.26,-25.2,;37.59,-24.43,;37.6,-22.89,;38.92,-22.13,;38.92,-20.59,;37.54,-27.61,;37.55,-29.16,;38.9,-26.88,;40.24,-27.61,;40.27,-29.14,;41.61,-29.88,;41.64,-31.41,;42.98,-32.15,;44.29,-31.36,;45.63,-32.09,;44.25,-29.82,;42.91,-29.09,;41.55,-26.82,;42.89,-27.55,;41.52,-25.28,)| Show InChI InChI=1S/C75H125N23O19/c1-11-13-18-47(91-71(114)54(33-38(3)4)95-69(112)51(26-29-57(79)101)93-74(117)60(40(7)12-2)98-70(113)52(27-30-58(102)103)89-64(107)43(10)87-73(116)59(39(5)6)97-62(105)41(8)77)67(110)96-55(35-45-36-83-37-85-45)72(115)92-50(25-28-56(78)100)68(111)90-48(20-15-17-32-84-75(81)82)65(108)86-42(9)63(106)88-49(19-14-16-31-76)66(109)94-53(61(80)104)34-44-21-23-46(99)24-22-44/h21-24,36-43,47-55,59-60,99H,11-20,25-35,76-77H2,1-10H3,(H2,78,100)(H2,79,101)(H2,80,104)(H,83,85)(H,86,108)(H,87,116)(H,88,106)(H,89,107)(H,90,111)(H,91,114)(H,92,115)(H,93,117)(H,94,109)(H,95,112)(H,96,110)(H,97,105)(H,98,113)(H,102,103)(H4,81,82,84)/t40-,41-,42-,43-,47-,48-,49-,50-,51-,52-,53-,54-,55-,59-,60-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.06E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]DPC-AJ1951 from PTH/PTH-related peptide receptor (unknown origin) expressed in HKRK-B28 cells |
Proc Natl Acad Sci U S A 104: 6846-51 (2007)
Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V |
More data for this
Ligand-Target Pair | |
Alpha-1D adrenergic receptor
(Homo sapiens (Human)) | BDBM50269979
(CHEMBL515170 | r-5-(2-E-cyclopropylvinyl)-t-3-ethy...)Show SMILES CC[C@@H]1O[C@@](\C=C\C2CC2)(c2c(F)c(F)ccc2NC1=O)C(F)(F)F |r| Show InChI InChI=1S/C17H16F5NO2/c1-2-12-15(24)23-11-6-5-10(18)14(19)13(11)16(25-12,17(20,21)22)8-7-9-3-4-9/h5-9,12H,2-4H2,1H3,(H,23,24)/b8-7+/t12-,16-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.38E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of adrenergic alpha1D receptor (unknown origin) |
Proc Natl Acad Sci U S A 104: 6846-51 (2007)
Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human)) | BDBM50269979
(CHEMBL515170 | r-5-(2-E-cyclopropylvinyl)-t-3-ethy...)Show SMILES CC[C@@H]1O[C@@](\C=C\C2CC2)(c2c(F)c(F)ccc2NC1=O)C(F)(F)F |r| Show InChI InChI=1S/C17H16F5NO2/c1-2-12-15(24)23-11-6-5-10(18)14(19)13(11)16(25-12,17(20,21)22)8-7-9-3-4-9/h5-9,12H,2-4H2,1H3,(H,23,24)/b8-7+/t12-,16-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of 5HT2A receptor (unknown origin) |
Proc Natl Acad Sci U S A 104: 6846-51 (2007)
Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V |
More data for this
Ligand-Target Pair | |
Substance-K receptor
(Homo sapiens (Human)) | BDBM50269979
(CHEMBL515170 | r-5-(2-E-cyclopropylvinyl)-t-3-ethy...)Show SMILES CC[C@@H]1O[C@@](\C=C\C2CC2)(c2c(F)c(F)ccc2NC1=O)C(F)(F)F |r| Show InChI InChI=1S/C17H16F5NO2/c1-2-12-15(24)23-11-6-5-10(18)14(19)13(11)16(25-12,17(20,21)22)8-7-9-3-4-9/h5-9,12H,2-4H2,1H3,(H,23,24)/b8-7+/t12-,16-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of neurokinin 2 receptor (unknown origin) |
Proc Natl Acad Sci U S A 104: 6846-51 (2007)
Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50269979
(CHEMBL515170 | r-5-(2-E-cyclopropylvinyl)-t-3-ethy...)Show SMILES CC[C@@H]1O[C@@](\C=C\C2CC2)(c2c(F)c(F)ccc2NC1=O)C(F)(F)F |r| Show InChI InChI=1S/C17H16F5NO2/c1-2-12-15(24)23-11-6-5-10(18)14(19)13(11)16(25-12,17(20,21)22)8-7-9-3-4-9/h5-9,12H,2-4H2,1H3,(H,23,24)/b8-7+/t12-,16-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Antagonist activity at PTH/PTH-related peptide receptor (unknown origin) expressed in HKRK-B28 cells assessed as inhibition of parathyroid hormone (1... |
Proc Natl Acad Sci U S A 104: 6846-51 (2007)
Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50269973
(Ala-Val-Ala-Glu-lle-Gln-Leu-Nle-His-Gln-Har-Ala-Ly...)Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r,wU:96.96,47.48,25.25,79.79,8.12,60.59,38.38,119.121,wD:16.21,91.92,53.53,43.43,70.70,4.4,105.105,29.34,(16.87,-8.93,;15.54,-8.19,;15.51,-6.66,;14.17,-5.91,;14.15,-4.38,;12.85,-3.57,;11.49,-4.29,;11.5,-5.84,;10.22,-3.42,;10.22,-1.88,;11.55,-1.11,;11.56,.43,;12.88,-1.88,;9,-4.32,;7.64,-3.6,;7.64,-2.05,;6.36,-4.47,;6.37,-6.01,;7.7,-6.78,;7.7,-8.31,;6.37,-9.09,;9.03,-9.09,;5.16,-3.57,;3.79,-4.31,;3.8,-5.86,;2.51,-3.44,;1.3,-4.34,;-.05,-3.62,;-.05,-2.07,;-1.33,-4.48,;-1.33,-6.02,;0,-6.8,;0,-8.33,;-1.32,-9.11,;1.34,-9.11,;-2.54,-3.59,;-3.9,-4.32,;-3.89,-5.86,;-5.17,-3.45,;-5.17,-1.91,;-6.39,-4.33,;-7.74,-3.6,;-7.74,-2.06,;-9.03,-4.47,;-10.24,-3.58,;-11.6,-4.31,;-11.59,-5.85,;-12.89,-3.44,;-12.89,-1.9,;-14.09,-4.33,;-9.03,-6.02,;-7.7,-6.79,;-10.36,-6.79,;2.51,-1.9,;3.85,-1.13,;1.18,-1.12,;1.16,.42,;15.34,-3.59,;15.35,-2.04,;16.7,-4.32,;17.92,-3.43,;17.92,-1.89,;19.25,-1.11,;20.72,-1.6,;21.63,-.37,;20.75,.89,;19.27,.43,;19.2,-4.3,;19.21,-5.84,;20.56,-3.57,;21.77,-4.46,;21.77,-6,;23.1,-6.78,;23.1,-8.31,;21.78,-9.08,;24.45,-9.08,;23.05,-3.59,;23.06,-2.05,;24.42,-4.32,;25.64,-3.43,;25.64,-1.89,;26.97,-1.11,;26.97,.43,;28.3,1.19,;28.3,2.72,;29.63,3.49,;29.63,5.02,;30.95,2.72,;26.91,-4.3,;26.92,-5.84,;28.27,-3.57,;29.48,-4.47,;29.48,-6.01,;30.76,-3.6,;30.77,-2.05,;32.13,-4.33,;33.34,-3.44,;33.34,-1.89,;34.68,-1.12,;34.68,.42,;36.01,1.18,;36.01,2.72,;34.62,-4.3,;34.63,-5.85,;35.98,-3.57,;37.2,-4.46,;37.21,-6,;38.53,-6.78,;40.03,-6.44,;40.82,-7.75,;39.8,-8.91,;40,-10.44,;38.76,-11.36,;37.35,-10.75,;37.16,-9.24,;38.4,-8.3,;38.48,-3.59,;38.48,-2.04,;39.83,-4.31,;41.13,-3.51,;41.08,-1.97,;42.38,-1.17,;43.73,-1.9,;45.03,-1.09,;44.98,.44,;46.28,1.25,;43.62,1.16,;42.33,.35,;42.48,-4.23,;43.79,-3.42,;42.53,-5.76,)| Show InChI InChI=1S/C86H135N25O20/c1-11-13-21-56(103-81(127)63(37-44(3)4)107-79(125)60(30-33-67(90)114)105-85(131)70(46(7)12-2)111-80(126)61(31-34-68(115)116)101-74(120)49(10)99-84(130)69(45(5)6)110-72(118)47(8)88)76(122)109-65(40-52-42-94-43-97-52)83(129)104-59(29-32-66(89)113)78(124)102-57(24-17-19-36-95-86(92)93)75(121)98-48(9)73(119)100-58(23-16-18-35-87)77(123)108-64(39-51-41-96-55-22-15-14-20-54(51)55)82(128)106-62(71(91)117)38-50-25-27-53(112)28-26-50/h14-15,20,22,25-28,41-49,56-65,69-70,96,112H,11-13,16-19,21,23-24,29-40,87-88H2,1-10H3,(H2,89,113)(H2,90,114)(H2,91,117)(H,94,97)(H,98,121)(H,99,130)(H,100,119)(H,101,120)(H,102,124)(H,103,127)(H,104,129)(H,105,131)(H,106,128)(H,107,125)(H,108,123)(H,109,122)(H,110,118)(H,111,126)(H,115,116)(H4,92,93,95)/t46-,47-,48-,49-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,69-,70-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.46E+3 | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Activity at human PTH/PTH-related peptide receptor expressed in SAOS2 cells assessed as cAMP formation |
Proc Natl Acad Sci U S A 104: 6846-51 (2007)
Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50269972
(Ala-Val-Ala-Glu-lle-Gln-Leu-Met-His-Gln-Har-Ala-Ly...)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1ccccc1-c1c2ccc(O)cc2oc2cc(=O)ccc12)C(N)=O |r,wU:4.4,44.43,60.59,79.79,26.27,96.96,17.17,119.121,wD:105.105,2.2,35.34,52.51,91.92,22.22,70.70,8.13,(4.06,-29.82,;4.08,-31.37,;5.42,-32.14,;6.75,-31.37,;5.42,-33.68,;4.2,-34.58,;2.86,-33.87,;2.86,-32.31,;1.59,-34.73,;1.59,-36.27,;2.91,-37.04,;2.91,-38.57,;1.59,-39.36,;4.24,-39.35,;.37,-33.83,;-.98,-34.56,;-.98,-36.11,;-2.26,-33.69,;-2.26,-32.15,;-3.5,-34.58,;-4.83,-33.85,;-4.82,-32.3,;-6.12,-34.72,;-7.33,-33.82,;-8.68,-34.55,;-8.68,-36.1,;-9.96,-33.68,;-9.96,-32.14,;-11.17,-34.57,;-6.12,-36.27,;-4.78,-37.03,;-7.44,-37.03,;6.7,-34.55,;6.7,-36.1,;8.06,-33.82,;9.27,-34.71,;9.27,-36.25,;10.61,-37.02,;10.61,-38.56,;9.27,-39.33,;11.93,-39.33,;10.54,-33.84,;10.55,-32.29,;11.91,-34.57,;13.13,-33.67,;13.13,-32.13,;14.46,-31.35,;14.46,-29.81,;15.79,-32.13,;14.4,-34.54,;14.4,-36.08,;15.76,-33.81,;16.96,-34.7,;16.96,-36.24,;18.3,-37.02,;18.3,-38.55,;19.63,-39.32,;18.24,-33.83,;18.26,-32.29,;19.61,-34.56,;20.83,-33.67,;20.83,-32.13,;22.16,-31.35,;23.63,-31.85,;24.54,-30.61,;23.65,-29.35,;22.18,-29.81,;22.11,-34.54,;22.11,-36.09,;23.46,-33.81,;24.68,-34.7,;24.68,-36.25,;26.01,-37.02,;26.01,-38.55,;24.68,-39.33,;27.35,-39.32,;25.96,-33.84,;25.97,-32.29,;27.33,-34.57,;28.54,-33.67,;28.55,-32.13,;29.88,-31.36,;29.88,-29.82,;31.21,-29.05,;31.21,-27.52,;32.54,-26.76,;32.54,-25.23,;33.86,-27.52,;29.82,-34.54,;29.82,-36.09,;31.18,-33.82,;32.39,-34.71,;32.39,-36.25,;33.67,-33.84,;33.67,-32.29,;35.03,-34.57,;36.25,-33.68,;36.25,-32.14,;37.59,-31.36,;37.59,-29.82,;38.91,-29.06,;38.91,-27.52,;37.53,-34.55,;37.54,-36.09,;38.89,-33.81,;40.11,-34.7,;40.11,-36.24,;41.44,-37.02,;42.94,-36.68,;43.73,-37.99,;42.71,-39.16,;42.9,-40.68,;41.67,-41.6,;40.25,-41,;40.07,-39.48,;41.3,-38.55,;41.38,-33.83,;41.39,-32.29,;42.74,-34.56,;44.06,-33.78,;44.05,-32.25,;42.72,-31.49,;42.71,-29.96,;41.38,-29.2,;41.36,-27.67,;42.66,-26.88,;44,-27.62,;42.63,-25.35,;41.1,-25.38,;40.3,-24.07,;41.05,-22.73,;42.58,-22.7,;43.37,-24.02,;44.89,-24,;45.64,-22.65,;44.85,-21.34,;45.6,-20,;47.14,-19.98,;47.88,-18.64,;47.92,-21.28,;47.19,-22.63,;47.98,-23.95,;47.22,-25.3,;48.01,-26.61,;47.25,-27.95,;48.03,-29.27,;45.72,-27.97,;44.93,-26.65,;45.68,-25.32,;45.39,-34.54,;45.4,-36.07,;46.72,-33.77,)| Show InChI InChI=1S/C102H146N26O23S/c1-11-54(6)85(128-96(145)73(35-38-82(133)134)119-89(138)57(9)116-100(149)84(53(4)5)127-87(136)55(7)104)101(150)123-72(34-37-81(106)132)94(143)124-75(44-52(2)3)97(146)122-74(39-43-152-10)95(144)126-77(46-59-50-110-51-114-59)99(148)121-71(33-36-80(105)131)93(142)120-69(28-18-21-42-112-102(108)109)91(140)115-56(8)88(137)118-70(27-16-19-40-103)92(141)125-76(45-58-49-113-67-25-15-14-22-62(58)67)98(147)117-68(86(107)135)26-17-20-41-111-90(139)64-24-13-12-23-63(64)83-65-31-29-60(129)47-78(65)151-79-48-61(130)30-32-66(79)83/h12-15,22-25,29-32,47-57,68-77,84-85,113,129H,11,16-21,26-28,33-46,103-104H2,1-10H3,(H2,105,131)(H2,106,132)(H2,107,135)(H,110,114)(H,111,139)(H,115,140)(H,116,149)(H,117,147)(H,118,137)(H,119,138)(H,120,142)(H,121,148)(H,122,146)(H,123,150)(H,124,143)(H,125,141)(H,126,144)(H,127,136)(H,128,145)(H,133,134)(H4,108,109,112)/t54-,55-,56-,57-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,84-,85-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Activity at human PTH/PTH-related peptide receptor expressed in SAOS2 cells assessed as cAMP formation |
Proc Natl Acad Sci U S A 104: 6846-51 (2007)
Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Rattus norvegicus (Rat)) | BDBM50269976
(Aib-Val-Aib-Glu-lle-Gln-Leu-Nle-His-Gln-Arg-Ala-Ly...)Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)C(C)(C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r,wU:81.81,25.25,62.61,8.12,97.97,wD:16.21,92.93,72.72,55.55,106.106,4.4,44.44,29.34,(16.82,-7.68,;15.49,-6.94,;15.46,-5.4,;14.12,-4.66,;14.1,-3.13,;12.8,-2.32,;11.44,-3.04,;11.45,-4.59,;10.17,-2.17,;10.17,-.63,;11.5,.14,;11.51,1.68,;12.83,-.63,;8.95,-3.07,;7.59,-2.35,;7.59,-.8,;6.31,-3.21,;6.31,-4.76,;7.65,-5.53,;7.65,-7.06,;6.32,-7.84,;8.98,-7.84,;5.11,-2.32,;3.74,-3.06,;3.75,-4.6,;2.46,-2.19,;1.25,-3.09,;-.11,-2.37,;-.1,-.82,;-1.38,-3.23,;-1.38,-4.77,;-.05,-5.55,;-.05,-7.08,;-1.38,-7.86,;1.29,-7.86,;-2.59,-2.34,;-3.95,-3.07,;-3.94,-4.61,;-5.22,-2.2,;-4.41,-.9,;-6.06,-3.48,;-6.53,-1.45,;-6.57,.09,;-5.22,.85,;-7.96,.78,;-7.96,2.28,;-9.35,2.94,;-10.59,2.02,;-9.36,4.47,;-7.82,4.49,;-10.89,4.45,;-9.38,6.01,;-9.3,.01,;-9.31,-1.52,;-10.63,.79,;2.46,-.65,;3.8,.13,;1.13,.13,;1.11,1.67,;15.29,-2.34,;15.3,-.79,;16.65,-3.07,;17.87,-2.18,;17.87,-.63,;19.2,.14,;20.67,-.35,;21.59,.88,;20.7,2.14,;19.22,1.68,;19.15,-3.04,;19.16,-4.59,;20.51,-2.32,;21.72,-3.21,;21.73,-4.75,;23.05,-5.53,;23.05,-7.06,;21.73,-7.83,;24.4,-7.83,;23,-2.34,;23.01,-.79,;24.37,-3.07,;25.59,-2.18,;25.59,-.64,;26.92,.14,;26.93,1.68,;28.25,2.44,;28.25,3.97,;29.58,4.74,;26.93,4.74,;26.86,-3.05,;26.87,-4.59,;28.22,-2.32,;29.43,-3.21,;29.43,-4.76,;30.71,-2.35,;30.72,-.8,;32.08,-3.08,;33.29,-2.19,;33.3,-.64,;34.63,.13,;34.63,1.67,;35.96,2.44,;35.96,3.98,;34.58,-3.05,;34.58,-4.6,;35.93,-2.31,;37.28,-3.05,;37.31,-4.58,;38.65,-5.32,;38.67,-6.85,;40.01,-7.59,;41.33,-6.8,;42.67,-7.53,;41.29,-5.26,;39.95,-4.53,;38.59,-2.26,;39.93,-2.99,;38.56,-.72,)| Show InChI InChI=1S/C76H127N23O19/c1-13-15-19-46(90-68(113)53(34-39(3)4)94-66(111)50(27-30-56(79)102)92-70(115)59(41(7)14-2)97-67(112)51(28-31-57(103)104)96-73(118)76(11,12)99-71(116)58(40(5)6)98-72(117)75(9,10)83)64(109)95-54(36-44-37-84-38-86-44)69(114)91-49(26-29-55(78)101)65(110)89-48(21-18-33-85-74(81)82)62(107)87-42(8)61(106)88-47(20-16-17-32-77)63(108)93-52(60(80)105)35-43-22-24-45(100)25-23-43/h22-25,37-42,46-54,58-59,100H,13-21,26-36,77,83H2,1-12H3,(H2,78,101)(H2,79,102)(H2,80,105)(H,84,86)(H,87,107)(H,88,106)(H,89,110)(H,90,113)(H,91,114)(H,92,115)(H,93,108)(H,94,111)(H,95,109)(H,96,118)(H,97,112)(H,98,117)(H,99,116)(H,103,104)(H4,81,82,85)/t41-,42-,46-,47-,48-,49-,50-,51-,52-,53-,54-,58-,59-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Activity at rat PTH/PTH-related peptide receptor expressed in rat UMR106 cells assessed as cAMP formation |
Proc Natl Acad Sci U S A 104: 6846-51 (2007)
Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Rattus norvegicus (Rat)) | BDBM50269974
(Ala-Val-Ala-Glu-lle-Gln-Leu-Nle-His-Gln-Har-Ala-Ly...)Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r,wU:79.79,25.25,47.48,60.59,8.12,38.38,96.96,wD:29.34,16.21,91.92,70.70,53.53,105.105,43.43,4.4,(19.79,-32.24,;18.45,-31.5,;18.43,-29.97,;17.09,-29.22,;17.07,-27.69,;15.77,-26.88,;14.41,-27.6,;14.41,-29.15,;13.14,-26.73,;13.14,-25.19,;14.47,-24.42,;14.47,-22.88,;15.8,-25.19,;11.92,-27.63,;10.55,-26.91,;10.56,-25.36,;9.28,-27.78,;9.28,-29.32,;10.62,-30.09,;10.62,-31.62,;9.28,-32.4,;11.94,-32.4,;8.07,-26.88,;6.71,-27.62,;6.71,-29.17,;5.43,-26.75,;4.22,-27.65,;2.86,-26.93,;2.87,-25.38,;1.59,-27.79,;1.59,-29.33,;2.92,-30.11,;2.92,-31.64,;1.59,-32.42,;4.25,-32.42,;.38,-26.9,;-.98,-27.63,;-.97,-29.17,;-2.25,-26.76,;-2.25,-25.22,;-3.47,-27.64,;-4.82,-26.91,;-4.82,-25.37,;-6.11,-27.78,;-7.32,-26.89,;-8.68,-27.62,;-8.67,-29.16,;-9.96,-26.75,;-9.96,-25.21,;-11.17,-27.64,;-6.11,-29.33,;-4.78,-30.1,;-7.44,-30.1,;5.43,-25.21,;6.76,-24.44,;4.09,-24.43,;4.08,-22.89,;18.25,-26.9,;18.27,-25.35,;19.62,-27.63,;20.84,-26.74,;20.84,-25.2,;22.17,-24.42,;23.64,-24.92,;24.55,-23.68,;23.66,-22.42,;22.19,-22.88,;22.12,-27.61,;22.12,-29.15,;23.47,-26.88,;24.69,-27.77,;24.69,-29.31,;26.02,-30.09,;26.02,-31.62,;24.69,-32.39,;27.36,-32.39,;25.97,-26.9,;25.98,-25.36,;27.34,-27.63,;28.55,-26.74,;28.55,-25.2,;29.89,-24.43,;29.89,-22.89,;31.22,-22.12,;31.22,-20.59,;32.54,-19.82,;32.54,-18.29,;33.87,-20.59,;29.83,-27.61,;29.83,-29.15,;31.19,-26.88,;32.4,-27.78,;32.4,-29.32,;33.68,-26.91,;33.68,-25.36,;35.04,-27.64,;36.26,-26.75,;36.26,-25.2,;37.59,-24.43,;37.6,-22.89,;38.92,-22.13,;38.92,-20.59,;37.54,-27.61,;37.55,-29.16,;38.9,-26.88,;40.24,-27.61,;40.27,-29.14,;41.61,-29.88,;41.64,-31.41,;42.98,-32.15,;44.29,-31.36,;45.63,-32.09,;44.25,-29.82,;42.91,-29.09,;41.55,-26.82,;42.89,-27.55,;41.52,-25.28,)| Show InChI InChI=1S/C75H125N23O19/c1-11-13-18-47(91-71(114)54(33-38(3)4)95-69(112)51(26-29-57(79)101)93-74(117)60(40(7)12-2)98-70(113)52(27-30-58(102)103)89-64(107)43(10)87-73(116)59(39(5)6)97-62(105)41(8)77)67(110)96-55(35-45-36-83-37-85-45)72(115)92-50(25-28-56(78)100)68(111)90-48(20-15-17-32-84-75(81)82)65(108)86-42(9)63(106)88-49(19-14-16-31-76)66(109)94-53(61(80)104)34-44-21-23-46(99)24-22-44/h21-24,36-43,47-55,59-60,99H,11-20,25-35,76-77H2,1-10H3,(H2,78,100)(H2,79,101)(H2,80,104)(H,83,85)(H,86,108)(H,87,116)(H,88,106)(H,89,107)(H,90,111)(H,91,114)(H,92,115)(H,93,117)(H,94,109)(H,95,112)(H,96,110)(H,97,105)(H,98,113)(H,102,103)(H4,81,82,84)/t40-,41-,42-,43-,47-,48-,49-,50-,51-,52-,53-,54-,55-,59-,60-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 344 | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Activity at rat PTH/PTH-related peptide receptor expressed in rat UMR106 cells assessed as cAMP formation |
Proc Natl Acad Sci U S A 104: 6846-51 (2007)
Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Rattus norvegicus (Rat)) | BDBM50269973
(Ala-Val-Ala-Glu-lle-Gln-Leu-Nle-His-Gln-Har-Ala-Ly...)Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r,wU:96.96,47.48,25.25,79.79,8.12,60.59,38.38,119.121,wD:16.21,91.92,53.53,43.43,70.70,4.4,105.105,29.34,(16.87,-8.93,;15.54,-8.19,;15.51,-6.66,;14.17,-5.91,;14.15,-4.38,;12.85,-3.57,;11.49,-4.29,;11.5,-5.84,;10.22,-3.42,;10.22,-1.88,;11.55,-1.11,;11.56,.43,;12.88,-1.88,;9,-4.32,;7.64,-3.6,;7.64,-2.05,;6.36,-4.47,;6.37,-6.01,;7.7,-6.78,;7.7,-8.31,;6.37,-9.09,;9.03,-9.09,;5.16,-3.57,;3.79,-4.31,;3.8,-5.86,;2.51,-3.44,;1.3,-4.34,;-.05,-3.62,;-.05,-2.07,;-1.33,-4.48,;-1.33,-6.02,;0,-6.8,;0,-8.33,;-1.32,-9.11,;1.34,-9.11,;-2.54,-3.59,;-3.9,-4.32,;-3.89,-5.86,;-5.17,-3.45,;-5.17,-1.91,;-6.39,-4.33,;-7.74,-3.6,;-7.74,-2.06,;-9.03,-4.47,;-10.24,-3.58,;-11.6,-4.31,;-11.59,-5.85,;-12.89,-3.44,;-12.89,-1.9,;-14.09,-4.33,;-9.03,-6.02,;-7.7,-6.79,;-10.36,-6.79,;2.51,-1.9,;3.85,-1.13,;1.18,-1.12,;1.16,.42,;15.34,-3.59,;15.35,-2.04,;16.7,-4.32,;17.92,-3.43,;17.92,-1.89,;19.25,-1.11,;20.72,-1.6,;21.63,-.37,;20.75,.89,;19.27,.43,;19.2,-4.3,;19.21,-5.84,;20.56,-3.57,;21.77,-4.46,;21.77,-6,;23.1,-6.78,;23.1,-8.31,;21.78,-9.08,;24.45,-9.08,;23.05,-3.59,;23.06,-2.05,;24.42,-4.32,;25.64,-3.43,;25.64,-1.89,;26.97,-1.11,;26.97,.43,;28.3,1.19,;28.3,2.72,;29.63,3.49,;29.63,5.02,;30.95,2.72,;26.91,-4.3,;26.92,-5.84,;28.27,-3.57,;29.48,-4.47,;29.48,-6.01,;30.76,-3.6,;30.77,-2.05,;32.13,-4.33,;33.34,-3.44,;33.34,-1.89,;34.68,-1.12,;34.68,.42,;36.01,1.18,;36.01,2.72,;34.62,-4.3,;34.63,-5.85,;35.98,-3.57,;37.2,-4.46,;37.21,-6,;38.53,-6.78,;40.03,-6.44,;40.82,-7.75,;39.8,-8.91,;40,-10.44,;38.76,-11.36,;37.35,-10.75,;37.16,-9.24,;38.4,-8.3,;38.48,-3.59,;38.48,-2.04,;39.83,-4.31,;41.13,-3.51,;41.08,-1.97,;42.38,-1.17,;43.73,-1.9,;45.03,-1.09,;44.98,.44,;46.28,1.25,;43.62,1.16,;42.33,.35,;42.48,-4.23,;43.79,-3.42,;42.53,-5.76,)| Show InChI InChI=1S/C86H135N25O20/c1-11-13-21-56(103-81(127)63(37-44(3)4)107-79(125)60(30-33-67(90)114)105-85(131)70(46(7)12-2)111-80(126)61(31-34-68(115)116)101-74(120)49(10)99-84(130)69(45(5)6)110-72(118)47(8)88)76(122)109-65(40-52-42-94-43-97-52)83(129)104-59(29-32-66(89)113)78(124)102-57(24-17-19-36-95-86(92)93)75(121)98-48(9)73(119)100-58(23-16-18-35-87)77(123)108-64(39-51-41-96-55-22-15-14-20-54(51)55)82(128)106-62(71(91)117)38-50-25-27-53(112)28-26-50/h14-15,20,22,25-28,41-49,56-65,69-70,96,112H,11-13,16-19,21,23-24,29-40,87-88H2,1-10H3,(H2,89,113)(H2,90,114)(H2,91,117)(H,94,97)(H,98,121)(H,99,130)(H,100,119)(H,101,120)(H,102,124)(H,103,127)(H,104,129)(H,105,131)(H,106,128)(H,107,125)(H,108,123)(H,109,122)(H,110,118)(H,111,126)(H,115,116)(H4,92,93,95)/t46-,47-,48-,49-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,69-,70-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 129 | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Activity at rat PTH/PTH-related peptide receptor expressed in rat UMR106 cells assessed as cAMP formation |
Proc Natl Acad Sci U S A 104: 6846-51 (2007)
Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Rattus norvegicus (Rat)) | BDBM50269972
(Ala-Val-Ala-Glu-lle-Gln-Leu-Met-His-Gln-Har-Ala-Ly...)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1ccccc1-c1c2ccc(O)cc2oc2cc(=O)ccc12)C(N)=O |r,wU:4.4,44.43,60.59,79.79,26.27,96.96,17.17,119.121,wD:105.105,2.2,35.34,52.51,91.92,22.22,70.70,8.13,(4.06,-29.82,;4.08,-31.37,;5.42,-32.14,;6.75,-31.37,;5.42,-33.68,;4.2,-34.58,;2.86,-33.87,;2.86,-32.31,;1.59,-34.73,;1.59,-36.27,;2.91,-37.04,;2.91,-38.57,;1.59,-39.36,;4.24,-39.35,;.37,-33.83,;-.98,-34.56,;-.98,-36.11,;-2.26,-33.69,;-2.26,-32.15,;-3.5,-34.58,;-4.83,-33.85,;-4.82,-32.3,;-6.12,-34.72,;-7.33,-33.82,;-8.68,-34.55,;-8.68,-36.1,;-9.96,-33.68,;-9.96,-32.14,;-11.17,-34.57,;-6.12,-36.27,;-4.78,-37.03,;-7.44,-37.03,;6.7,-34.55,;6.7,-36.1,;8.06,-33.82,;9.27,-34.71,;9.27,-36.25,;10.61,-37.02,;10.61,-38.56,;9.27,-39.33,;11.93,-39.33,;10.54,-33.84,;10.55,-32.29,;11.91,-34.57,;13.13,-33.67,;13.13,-32.13,;14.46,-31.35,;14.46,-29.81,;15.79,-32.13,;14.4,-34.54,;14.4,-36.08,;15.76,-33.81,;16.96,-34.7,;16.96,-36.24,;18.3,-37.02,;18.3,-38.55,;19.63,-39.32,;18.24,-33.83,;18.26,-32.29,;19.61,-34.56,;20.83,-33.67,;20.83,-32.13,;22.16,-31.35,;23.63,-31.85,;24.54,-30.61,;23.65,-29.35,;22.18,-29.81,;22.11,-34.54,;22.11,-36.09,;23.46,-33.81,;24.68,-34.7,;24.68,-36.25,;26.01,-37.02,;26.01,-38.55,;24.68,-39.33,;27.35,-39.32,;25.96,-33.84,;25.97,-32.29,;27.33,-34.57,;28.54,-33.67,;28.55,-32.13,;29.88,-31.36,;29.88,-29.82,;31.21,-29.05,;31.21,-27.52,;32.54,-26.76,;32.54,-25.23,;33.86,-27.52,;29.82,-34.54,;29.82,-36.09,;31.18,-33.82,;32.39,-34.71,;32.39,-36.25,;33.67,-33.84,;33.67,-32.29,;35.03,-34.57,;36.25,-33.68,;36.25,-32.14,;37.59,-31.36,;37.59,-29.82,;38.91,-29.06,;38.91,-27.52,;37.53,-34.55,;37.54,-36.09,;38.89,-33.81,;40.11,-34.7,;40.11,-36.24,;41.44,-37.02,;42.94,-36.68,;43.73,-37.99,;42.71,-39.16,;42.9,-40.68,;41.67,-41.6,;40.25,-41,;40.07,-39.48,;41.3,-38.55,;41.38,-33.83,;41.39,-32.29,;42.74,-34.56,;44.06,-33.78,;44.05,-32.25,;42.72,-31.49,;42.71,-29.96,;41.38,-29.2,;41.36,-27.67,;42.66,-26.88,;44,-27.62,;42.63,-25.35,;41.1,-25.38,;40.3,-24.07,;41.05,-22.73,;42.58,-22.7,;43.37,-24.02,;44.89,-24,;45.64,-22.65,;44.85,-21.34,;45.6,-20,;47.14,-19.98,;47.88,-18.64,;47.92,-21.28,;47.19,-22.63,;47.98,-23.95,;47.22,-25.3,;48.01,-26.61,;47.25,-27.95,;48.03,-29.27,;45.72,-27.97,;44.93,-26.65,;45.68,-25.32,;45.39,-34.54,;45.4,-36.07,;46.72,-33.77,)| Show InChI InChI=1S/C102H146N26O23S/c1-11-54(6)85(128-96(145)73(35-38-82(133)134)119-89(138)57(9)116-100(149)84(53(4)5)127-87(136)55(7)104)101(150)123-72(34-37-81(106)132)94(143)124-75(44-52(2)3)97(146)122-74(39-43-152-10)95(144)126-77(46-59-50-110-51-114-59)99(148)121-71(33-36-80(105)131)93(142)120-69(28-18-21-42-112-102(108)109)91(140)115-56(8)88(137)118-70(27-16-19-40-103)92(141)125-76(45-58-49-113-67-25-15-14-22-62(58)67)98(147)117-68(86(107)135)26-17-20-41-111-90(139)64-24-13-12-23-63(64)83-65-31-29-60(129)47-78(65)151-79-48-61(130)30-32-66(79)83/h12-15,22-25,29-32,47-57,68-77,84-85,113,129H,11,16-21,26-28,33-46,103-104H2,1-10H3,(H2,105,131)(H2,106,132)(H2,107,135)(H,110,114)(H,111,139)(H,115,140)(H,116,149)(H,117,147)(H,118,137)(H,119,138)(H,120,142)(H,121,148)(H,122,146)(H,123,150)(H,124,143)(H,125,141)(H,126,144)(H,127,136)(H,128,145)(H,133,134)(H4,108,109,112)/t54-,55-,56-,57-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,84-,85-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 251 | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Activity at rat PTH/PTH-related peptide receptor expressed in rat UMR106 cells assessed as cAMP formation |
Proc Natl Acad Sci U S A 104: 6846-51 (2007)
Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50269978
(Aib-Val-Aib-Glu-lle-Gln-Leu-Nle-His-Gln-Arg-Ala-Fl...)Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)C(C)(C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCNC(=O)c1ccccc1-c1c2ccc(O)cc2oc2cc(=O)ccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r,wU:62.61,8.12,81.81,97.97,25.25,wD:55.55,44.44,4.4,29.34,92.93,72.72,130.134,16.21,(17.08,-55.29,;15.74,-54.54,;15.72,-53,;14.37,-52.25,;14.35,-50.72,;13.05,-49.9,;11.68,-50.63,;11.69,-52.18,;10.41,-49.76,;10.41,-48.21,;11.75,-47.44,;11.75,-45.89,;13.08,-48.22,;9.18,-50.66,;7.82,-49.93,;7.82,-48.38,;6.54,-50.81,;6.54,-52.35,;7.88,-53.13,;7.88,-54.66,;6.54,-55.44,;9.21,-55.44,;5.33,-49.91,;3.96,-50.65,;3.97,-52.2,;2.68,-49.78,;1.46,-50.68,;.1,-49.96,;.11,-48.4,;-1.17,-50.82,;-1.17,-52.37,;.16,-53.14,;.16,-54.68,;-1.17,-55.47,;1.5,-55.47,;-2.39,-49.93,;-3.75,-50.66,;-3.74,-52.21,;-5.02,-49.78,;-4.21,-48.48,;-5.88,-51.07,;-6.33,-49.03,;-6.37,-47.49,;-5.03,-46.73,;-7.78,-46.8,;-7.77,-45.29,;-9.18,-44.63,;-10.4,-45.56,;-9.17,-43.1,;-7.63,-43.08,;-10.7,-43.12,;-9.19,-41.56,;-9.11,-47.57,;-9.14,-49.11,;-10.44,-46.79,;2.68,-48.23,;4.02,-47.46,;1.34,-47.45,;1.33,-45.91,;15.54,-49.93,;15.55,-48.38,;16.91,-50.66,;18.13,-49.76,;18.13,-48.22,;19.47,-47.44,;20.94,-47.94,;21.86,-46.7,;20.97,-45.43,;19.48,-45.89,;19.42,-50.64,;19.42,-52.19,;20.78,-49.91,;22,-50.8,;22,-52.35,;23.33,-53.12,;23.33,-54.66,;22,-55.44,;24.68,-55.43,;23.28,-49.93,;23.29,-48.38,;24.65,-50.66,;25.87,-49.77,;25.87,-48.22,;27.21,-47.45,;27.21,-45.9,;28.54,-45.13,;28.54,-43.6,;29.87,-42.83,;27.21,-42.83,;27.15,-50.64,;27.15,-52.19,;28.51,-49.91,;29.72,-50.81,;29.73,-52.35,;31.01,-49.93,;31.01,-48.38,;32.36,-50.66,;33.68,-49.87,;33.68,-48.34,;32.34,-47.58,;32.33,-46.04,;31,-45.28,;30.97,-43.74,;32.28,-42.95,;33.63,-43.7,;32.25,-41.42,;30.72,-41.45,;29.92,-40.13,;30.67,-38.78,;32.2,-38.76,;32.99,-40.08,;34.52,-40.06,;35.27,-38.71,;34.48,-37.39,;35.23,-36.05,;36.77,-36.03,;37.52,-34.69,;37.56,-37.34,;36.82,-38.69,;37.62,-40.01,;36.85,-41.36,;37.65,-42.68,;36.89,-44.03,;37.67,-45.35,;35.35,-44.05,;34.56,-42.72,;35.31,-41.38,;35.02,-50.64,;35.03,-52.17,;36.35,-49.86,;37.68,-50.62,;37.69,-52.15,;39.03,-52.92,;39.02,-54.45,;40.36,-55.21,;41.69,-54.44,;43.02,-55.2,;41.67,-52.89,;40.34,-52.14,;39.01,-49.84,;40.34,-50.6,;39,-48.31,)| Show InChI InChI=1S/C96H137N23O23/c1-13-15-23-62(110-88(136)69(42-49(3)4)114-86(134)66(35-38-74(98)124)112-90(138)78(51(7)14-2)117-87(135)67(36-39-75(125)126)116-93(141)96(11,12)119-91(139)77(50(5)6)118-92(140)95(9,10)102)84(132)115-70(44-54-47-103-48-106-54)89(137)111-65(34-37-73(97)123)85(133)109-64(25-20-41-105-94(100)101)82(130)107-52(8)80(128)108-63(83(131)113-68(79(99)127)43-53-26-28-55(120)29-27-53)24-18-19-40-104-81(129)59-22-17-16-21-58(59)76-60-32-30-56(121)45-71(60)142-72-46-57(122)31-33-61(72)76/h16-17,21-22,26-33,45-52,62-70,77-78,120-121H,13-15,18-20,23-25,34-44,102H2,1-12H3,(H2,97,123)(H2,98,124)(H2,99,127)(H,103,106)(H,104,129)(H,107,130)(H,108,128)(H,109,133)(H,110,136)(H,111,137)(H,112,138)(H,113,131)(H,114,134)(H,115,132)(H,116,141)(H,117,135)(H,118,140)(H,119,139)(H,125,126)(H4,100,101,105)/t51-,52-,62-,63-,64-,65-,66-,67-,68-,69-,70-,77-,78-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.920 | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Activity at human PTH/PTH-related peptide receptor expressed in HEK293 cells assessed as induction of luciferase activity by CRE-luciferase reporter ... |
Proc Natl Acad Sci U S A 104: 6846-51 (2007)
Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50269977
(Aib-Val-Aib-Glu-lle-Gln-Leu-Nle-His-Gln-Arg-Ala-Ly...)Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)C(C)(C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCNC(=O)c1ccccc1-c1c2ccc(O)cc2oc2cc(=O)ccc12)C(N)=O |r,wU:62.61,8.12,97.97,81.81,25.25,118.119,wD:55.55,106.106,4.4,44.44,29.34,16.21,92.93,72.72,(16.67,-31.38,;15.33,-30.63,;15.31,-29.09,;13.97,-28.35,;13.94,-26.81,;12.64,-26,;11.27,-26.72,;11.28,-28.28,;10,-25.85,;10,-24.31,;11.34,-23.53,;11.34,-21.99,;12.67,-24.31,;8.78,-26.75,;7.41,-26.03,;7.42,-24.48,;6.13,-26.9,;6.14,-28.44,;7.47,-29.22,;7.47,-30.76,;6.14,-31.53,;8.8,-31.53,;4.92,-26,;3.55,-26.74,;3.56,-28.29,;2.27,-25.87,;1.05,-26.77,;-.3,-26.05,;-.3,-24.49,;-1.58,-26.92,;-1.58,-28.46,;-.25,-29.24,;-.25,-30.77,;-1.58,-31.56,;1.09,-31.56,;-2.8,-26.02,;-4.15,-26.75,;-4.15,-28.3,;-5.43,-25.88,;-4.62,-24.58,;-6.27,-27.16,;-6.75,-25.13,;-6.78,-23.59,;-5.43,-22.83,;-8.17,-22.89,;-8.18,-21.39,;-9.57,-20.73,;-10.82,-21.65,;-9.58,-19.19,;-8.04,-19.18,;-11.11,-19.21,;-9.6,-17.65,;-9.53,-23.66,;-9.53,-25.2,;-10.85,-22.88,;2.27,-24.33,;3.61,-23.55,;.93,-23.55,;.92,-22,;15.13,-26.02,;15.15,-24.47,;16.5,-26.75,;17.72,-25.86,;17.72,-24.31,;19.06,-23.53,;20.53,-24.03,;21.45,-22.79,;20.56,-21.53,;19.07,-21.99,;19.01,-26.73,;19.01,-28.28,;20.37,-26,;21.59,-26.89,;21.59,-28.44,;22.92,-29.21,;22.92,-30.75,;21.59,-31.53,;24.27,-31.53,;22.87,-26.02,;22.88,-24.47,;24.24,-26.75,;25.46,-25.86,;25.46,-24.31,;26.8,-23.54,;26.8,-21.99,;28.13,-21.23,;28.13,-19.69,;29.46,-18.92,;26.8,-18.92,;26.74,-26.73,;26.74,-28.28,;28.1,-26,;29.31,-26.9,;29.31,-28.44,;30.6,-26.03,;30.6,-24.48,;31.97,-26.76,;33.19,-25.87,;33.19,-24.32,;34.53,-23.54,;34.53,-22,;35.86,-21.23,;35.86,-19.69,;34.47,-26.74,;34.48,-28.29,;35.83,-26,;37.18,-26.73,;37.21,-28.27,;38.56,-29.01,;38.58,-30.54,;39.93,-31.28,;41.24,-30.49,;42.59,-31.23,;41.2,-28.95,;39.86,-28.21,;38.49,-25.94,;38.46,-24.4,;39.84,-26.67,;41.16,-25.89,;41.15,-24.36,;39.82,-23.6,;39.81,-22.06,;38.48,-21.3,;38.45,-19.76,;39.76,-18.97,;41.1,-19.72,;39.72,-17.44,;38.19,-17.47,;37.4,-16.15,;38.14,-14.8,;39.68,-14.78,;40.47,-16.1,;41.99,-16.08,;42.74,-14.73,;41.96,-13.41,;42.71,-12.07,;44.25,-12.05,;44.99,-10.71,;45.04,-13.36,;44.3,-14.71,;45.1,-16.03,;44.33,-17.38,;45.12,-18.7,;44.36,-20.05,;45.15,-21.37,;42.82,-20.07,;42.04,-18.74,;42.79,-17.4,;42.5,-26.65,;42.51,-28.19,;43.83,-25.88,)| Show InChI InChI=1S/C102H149N25O24/c1-13-15-25-67(118-93(144)73(46-53(3)4)121-91(142)71(38-41-79(105)132)120-96(147)83(55(7)14-2)125-92(143)72(39-42-80(133)134)124-99(150)102(11,12)127-97(148)82(54(5)6)126-98(149)101(9,10)109)88(139)123-75(48-58-51-110-52-113-58)95(146)119-70(37-40-78(104)131)90(141)117-69(28-22-45-112-100(107)108)87(138)114-56(8)85(136)116-68(27-18-20-43-103)89(140)122-74(47-57-29-31-59(128)32-30-57)94(145)115-66(84(106)135)26-19-21-44-111-86(137)63-24-17-16-23-62(63)81-64-35-33-60(129)49-76(64)151-77-50-61(130)34-36-65(77)81/h16-17,23-24,29-36,49-56,66-75,82-83,128-129H,13-15,18-22,25-28,37-48,103,109H2,1-12H3,(H2,104,131)(H2,105,132)(H2,106,135)(H,110,113)(H,111,137)(H,114,138)(H,115,145)(H,116,136)(H,117,141)(H,118,144)(H,119,146)(H,120,147)(H,121,142)(H,122,140)(H,123,139)(H,124,150)(H,125,143)(H,126,149)(H,127,148)(H,133,134)(H4,107,108,112)/t55-,56-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,82-,83-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Activity at human PTH/PTH-related peptide receptor expressed in HEK293 cells assessed as induction of luciferase activity by CRE-luciferase reporter ... |
Proc Natl Acad Sci U S A 104: 6846-51 (2007)
Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50269976
(Aib-Val-Aib-Glu-lle-Gln-Leu-Nle-His-Gln-Arg-Ala-Ly...)Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)C(C)(C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r,wU:81.81,25.25,62.61,8.12,97.97,wD:16.21,92.93,72.72,55.55,106.106,4.4,44.44,29.34,(16.82,-7.68,;15.49,-6.94,;15.46,-5.4,;14.12,-4.66,;14.1,-3.13,;12.8,-2.32,;11.44,-3.04,;11.45,-4.59,;10.17,-2.17,;10.17,-.63,;11.5,.14,;11.51,1.68,;12.83,-.63,;8.95,-3.07,;7.59,-2.35,;7.59,-.8,;6.31,-3.21,;6.31,-4.76,;7.65,-5.53,;7.65,-7.06,;6.32,-7.84,;8.98,-7.84,;5.11,-2.32,;3.74,-3.06,;3.75,-4.6,;2.46,-2.19,;1.25,-3.09,;-.11,-2.37,;-.1,-.82,;-1.38,-3.23,;-1.38,-4.77,;-.05,-5.55,;-.05,-7.08,;-1.38,-7.86,;1.29,-7.86,;-2.59,-2.34,;-3.95,-3.07,;-3.94,-4.61,;-5.22,-2.2,;-4.41,-.9,;-6.06,-3.48,;-6.53,-1.45,;-6.57,.09,;-5.22,.85,;-7.96,.78,;-7.96,2.28,;-9.35,2.94,;-10.59,2.02,;-9.36,4.47,;-7.82,4.49,;-10.89,4.45,;-9.38,6.01,;-9.3,.01,;-9.31,-1.52,;-10.63,.79,;2.46,-.65,;3.8,.13,;1.13,.13,;1.11,1.67,;15.29,-2.34,;15.3,-.79,;16.65,-3.07,;17.87,-2.18,;17.87,-.63,;19.2,.14,;20.67,-.35,;21.59,.88,;20.7,2.14,;19.22,1.68,;19.15,-3.04,;19.16,-4.59,;20.51,-2.32,;21.72,-3.21,;21.73,-4.75,;23.05,-5.53,;23.05,-7.06,;21.73,-7.83,;24.4,-7.83,;23,-2.34,;23.01,-.79,;24.37,-3.07,;25.59,-2.18,;25.59,-.64,;26.92,.14,;26.93,1.68,;28.25,2.44,;28.25,3.97,;29.58,4.74,;26.93,4.74,;26.86,-3.05,;26.87,-4.59,;28.22,-2.32,;29.43,-3.21,;29.43,-4.76,;30.71,-2.35,;30.72,-.8,;32.08,-3.08,;33.29,-2.19,;33.3,-.64,;34.63,.13,;34.63,1.67,;35.96,2.44,;35.96,3.98,;34.58,-3.05,;34.58,-4.6,;35.93,-2.31,;37.28,-3.05,;37.31,-4.58,;38.65,-5.32,;38.67,-6.85,;40.01,-7.59,;41.33,-6.8,;42.67,-7.53,;41.29,-5.26,;39.95,-4.53,;38.59,-2.26,;39.93,-2.99,;38.56,-.72,)| Show InChI InChI=1S/C76H127N23O19/c1-13-15-19-46(90-68(113)53(34-39(3)4)94-66(111)50(27-30-56(79)102)92-70(115)59(41(7)14-2)97-67(112)51(28-31-57(103)104)96-73(118)76(11,12)99-71(116)58(40(5)6)98-72(117)75(9,10)83)64(109)95-54(36-44-37-84-38-86-44)69(114)91-49(26-29-55(78)101)65(110)89-48(21-18-33-85-74(81)82)62(107)87-42(8)61(106)88-47(20-16-17-32-77)63(108)93-52(60(80)105)35-43-22-24-45(100)25-23-43/h22-25,37-42,46-54,58-59,100H,13-21,26-36,77,83H2,1-12H3,(H2,78,101)(H2,79,102)(H2,80,105)(H,84,86)(H,87,107)(H,88,106)(H,89,110)(H,90,113)(H,91,114)(H,92,115)(H,93,108)(H,94,111)(H,95,109)(H,96,118)(H,97,112)(H,98,117)(H,99,116)(H,103,104)(H4,81,82,85)/t41-,42-,46-,47-,48-,49-,50-,51-,52-,53-,54-,58-,59-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.150 | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Activity at human PTH/PTH-related peptide receptor expressed in HEK293 cells assessed as induction of luciferase activity by CRE-luciferase reporter ... |
Proc Natl Acad Sci U S A 104: 6846-51 (2007)
Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50269975
(Aib-Val-Aib-Glu-lle-Gln-Leu-Nle-His-Gln-Har-Ala-Ly...)Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)C(C)(C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r,wU:81.81,25.25,62.61,8.12,98.98,wD:16.21,93.94,72.72,55.55,107.107,4.4,44.44,29.34,(18.87,-52.12,;17.53,-51.38,;17.51,-49.85,;16.17,-49.1,;16.14,-47.57,;14.85,-46.76,;13.48,-47.48,;13.49,-49.03,;12.21,-46.62,;12.21,-45.07,;13.55,-44.3,;13.55,-42.76,;14.87,-45.07,;10.99,-47.51,;9.63,-46.79,;9.63,-45.24,;8.36,-47.66,;8.36,-49.2,;9.69,-49.97,;9.69,-51.5,;8.36,-52.28,;11.02,-52.28,;7.15,-46.77,;5.78,-47.5,;5.79,-49.05,;4.5,-46.63,;3.29,-47.53,;1.94,-46.81,;1.94,-45.26,;.66,-47.67,;.66,-49.22,;1.99,-49.99,;1.99,-51.52,;.67,-52.3,;3.33,-52.3,;-.55,-46.78,;-1.91,-47.51,;-1.9,-49.05,;-3.18,-46.64,;-2.37,-45.34,;-4.02,-47.92,;-4.49,-45.89,;-4.52,-44.35,;-3.18,-43.6,;-5.92,-43.66,;-5.92,-42.16,;-7.31,-41.5,;-8.55,-42.43,;-7.31,-39.97,;-5.78,-39.96,;-8.85,-39.99,;-7.34,-38.44,;-7.26,-44.43,;-7.27,-45.97,;-8.58,-43.65,;4.5,-45.09,;5.84,-44.32,;3.17,-44.32,;3.16,-42.77,;17.33,-46.78,;17.34,-45.23,;18.7,-47.51,;19.91,-46.62,;19.91,-45.08,;21.25,-44.3,;22.72,-44.8,;23.63,-43.56,;22.74,-42.3,;21.26,-42.76,;21.19,-47.49,;21.2,-49.03,;22.55,-46.76,;23.77,-47.65,;23.77,-49.19,;25.09,-49.97,;25.1,-51.5,;23.77,-52.27,;26.44,-52.27,;25.05,-46.78,;25.05,-45.24,;26.42,-47.51,;27.63,-46.62,;27.63,-45.08,;28.97,-44.31,;28.97,-42.77,;30.3,-42,;30.3,-40.47,;31.62,-39.7,;31.62,-38.17,;32.95,-40.47,;28.9,-47.49,;28.91,-49.04,;30.27,-46.77,;31.47,-47.66,;31.47,-49.2,;32.75,-46.79,;32.76,-45.24,;34.12,-47.52,;35.34,-46.63,;35.34,-45.09,;36.67,-44.31,;36.67,-42.77,;38,-42.01,;38,-40.47,;36.62,-47.5,;36.62,-49.04,;37.98,-46.76,;39.32,-47.49,;39.35,-49.03,;40.69,-49.76,;40.72,-51.29,;42.06,-52.03,;43.37,-51.24,;44.71,-51.97,;43.33,-49.7,;41.99,-48.97,;40.63,-46.7,;41.97,-47.43,;40.6,-45.17,)| Show InChI InChI=1S/C77H129N23O19/c1-13-15-20-47(91-69(114)54(35-40(3)4)95-67(112)51(28-31-57(80)103)93-71(116)60(42(7)14-2)98-68(113)52(29-32-58(104)105)97-74(119)77(11,12)100-72(117)59(41(5)6)99-73(118)76(9,10)84)65(110)96-55(37-45-38-85-39-87-45)70(115)92-50(27-30-56(79)102)66(111)90-48(22-17-19-34-86-75(82)83)63(108)88-43(8)62(107)89-49(21-16-18-33-78)64(109)94-53(61(81)106)36-44-23-25-46(101)26-24-44/h23-26,38-43,47-55,59-60,101H,13-22,27-37,78,84H2,1-12H3,(H2,79,102)(H2,80,103)(H2,81,106)(H,85,87)(H,88,108)(H,89,107)(H,90,111)(H,91,114)(H,92,115)(H,93,116)(H,94,109)(H,95,112)(H,96,110)(H,97,119)(H,98,113)(H,99,118)(H,100,117)(H,104,105)(H4,82,83,86)/t42-,43-,47-,48-,49-,50-,51-,52-,53-,54-,55-,59-,60-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.0600 | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Activity at human PTH/PTH-related peptide receptor expressed in HEK293 cells assessed as induction of luciferase activity by CRE-luciferase reporter ... |
Proc Natl Acad Sci U S A 104: 6846-51 (2007)
Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50269974
(Ala-Val-Ala-Glu-lle-Gln-Leu-Nle-His-Gln-Har-Ala-Ly...)Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r,wU:79.79,25.25,47.48,60.59,8.12,38.38,96.96,wD:29.34,16.21,91.92,70.70,53.53,105.105,43.43,4.4,(19.79,-32.24,;18.45,-31.5,;18.43,-29.97,;17.09,-29.22,;17.07,-27.69,;15.77,-26.88,;14.41,-27.6,;14.41,-29.15,;13.14,-26.73,;13.14,-25.19,;14.47,-24.42,;14.47,-22.88,;15.8,-25.19,;11.92,-27.63,;10.55,-26.91,;10.56,-25.36,;9.28,-27.78,;9.28,-29.32,;10.62,-30.09,;10.62,-31.62,;9.28,-32.4,;11.94,-32.4,;8.07,-26.88,;6.71,-27.62,;6.71,-29.17,;5.43,-26.75,;4.22,-27.65,;2.86,-26.93,;2.87,-25.38,;1.59,-27.79,;1.59,-29.33,;2.92,-30.11,;2.92,-31.64,;1.59,-32.42,;4.25,-32.42,;.38,-26.9,;-.98,-27.63,;-.97,-29.17,;-2.25,-26.76,;-2.25,-25.22,;-3.47,-27.64,;-4.82,-26.91,;-4.82,-25.37,;-6.11,-27.78,;-7.32,-26.89,;-8.68,-27.62,;-8.67,-29.16,;-9.96,-26.75,;-9.96,-25.21,;-11.17,-27.64,;-6.11,-29.33,;-4.78,-30.1,;-7.44,-30.1,;5.43,-25.21,;6.76,-24.44,;4.09,-24.43,;4.08,-22.89,;18.25,-26.9,;18.27,-25.35,;19.62,-27.63,;20.84,-26.74,;20.84,-25.2,;22.17,-24.42,;23.64,-24.92,;24.55,-23.68,;23.66,-22.42,;22.19,-22.88,;22.12,-27.61,;22.12,-29.15,;23.47,-26.88,;24.69,-27.77,;24.69,-29.31,;26.02,-30.09,;26.02,-31.62,;24.69,-32.39,;27.36,-32.39,;25.97,-26.9,;25.98,-25.36,;27.34,-27.63,;28.55,-26.74,;28.55,-25.2,;29.89,-24.43,;29.89,-22.89,;31.22,-22.12,;31.22,-20.59,;32.54,-19.82,;32.54,-18.29,;33.87,-20.59,;29.83,-27.61,;29.83,-29.15,;31.19,-26.88,;32.4,-27.78,;32.4,-29.32,;33.68,-26.91,;33.68,-25.36,;35.04,-27.64,;36.26,-26.75,;36.26,-25.2,;37.59,-24.43,;37.6,-22.89,;38.92,-22.13,;38.92,-20.59,;37.54,-27.61,;37.55,-29.16,;38.9,-26.88,;40.24,-27.61,;40.27,-29.14,;41.61,-29.88,;41.64,-31.41,;42.98,-32.15,;44.29,-31.36,;45.63,-32.09,;44.25,-29.82,;42.91,-29.09,;41.55,-26.82,;42.89,-27.55,;41.52,-25.28,)| Show InChI InChI=1S/C75H125N23O19/c1-11-13-18-47(91-71(114)54(33-38(3)4)95-69(112)51(26-29-57(79)101)93-74(117)60(40(7)12-2)98-70(113)52(27-30-58(102)103)89-64(107)43(10)87-73(116)59(39(5)6)97-62(105)41(8)77)67(110)96-55(35-45-36-83-37-85-45)72(115)92-50(25-28-56(78)100)68(111)90-48(20-15-17-32-84-75(81)82)65(108)86-42(9)63(106)88-49(19-14-16-31-76)66(109)94-53(61(80)104)34-44-21-23-46(99)24-22-44/h21-24,36-43,47-55,59-60,99H,11-20,25-35,76-77H2,1-10H3,(H2,78,100)(H2,79,101)(H2,80,104)(H,83,85)(H,86,108)(H,87,116)(H,88,106)(H,89,107)(H,90,111)(H,91,114)(H,92,115)(H,93,117)(H,94,109)(H,95,112)(H,96,110)(H,97,105)(H,98,113)(H,102,103)(H4,81,82,84)/t40-,41-,42-,43-,47-,48-,49-,50-,51-,52-,53-,54-,55-,59-,60-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 13 | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Activity at human PTH/PTH-related peptide receptor expressed in HEK293 cells assessed as induction of luciferase activity by CRE-luciferase reporter ... |
Proc Natl Acad Sci U S A 104: 6846-51 (2007)
Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50269973
(Ala-Val-Ala-Glu-lle-Gln-Leu-Nle-His-Gln-Har-Ala-Ly...)Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r,wU:96.96,47.48,25.25,79.79,8.12,60.59,38.38,119.121,wD:16.21,91.92,53.53,43.43,70.70,4.4,105.105,29.34,(16.87,-8.93,;15.54,-8.19,;15.51,-6.66,;14.17,-5.91,;14.15,-4.38,;12.85,-3.57,;11.49,-4.29,;11.5,-5.84,;10.22,-3.42,;10.22,-1.88,;11.55,-1.11,;11.56,.43,;12.88,-1.88,;9,-4.32,;7.64,-3.6,;7.64,-2.05,;6.36,-4.47,;6.37,-6.01,;7.7,-6.78,;7.7,-8.31,;6.37,-9.09,;9.03,-9.09,;5.16,-3.57,;3.79,-4.31,;3.8,-5.86,;2.51,-3.44,;1.3,-4.34,;-.05,-3.62,;-.05,-2.07,;-1.33,-4.48,;-1.33,-6.02,;0,-6.8,;0,-8.33,;-1.32,-9.11,;1.34,-9.11,;-2.54,-3.59,;-3.9,-4.32,;-3.89,-5.86,;-5.17,-3.45,;-5.17,-1.91,;-6.39,-4.33,;-7.74,-3.6,;-7.74,-2.06,;-9.03,-4.47,;-10.24,-3.58,;-11.6,-4.31,;-11.59,-5.85,;-12.89,-3.44,;-12.89,-1.9,;-14.09,-4.33,;-9.03,-6.02,;-7.7,-6.79,;-10.36,-6.79,;2.51,-1.9,;3.85,-1.13,;1.18,-1.12,;1.16,.42,;15.34,-3.59,;15.35,-2.04,;16.7,-4.32,;17.92,-3.43,;17.92,-1.89,;19.25,-1.11,;20.72,-1.6,;21.63,-.37,;20.75,.89,;19.27,.43,;19.2,-4.3,;19.21,-5.84,;20.56,-3.57,;21.77,-4.46,;21.77,-6,;23.1,-6.78,;23.1,-8.31,;21.78,-9.08,;24.45,-9.08,;23.05,-3.59,;23.06,-2.05,;24.42,-4.32,;25.64,-3.43,;25.64,-1.89,;26.97,-1.11,;26.97,.43,;28.3,1.19,;28.3,2.72,;29.63,3.49,;29.63,5.02,;30.95,2.72,;26.91,-4.3,;26.92,-5.84,;28.27,-3.57,;29.48,-4.47,;29.48,-6.01,;30.76,-3.6,;30.77,-2.05,;32.13,-4.33,;33.34,-3.44,;33.34,-1.89,;34.68,-1.12,;34.68,.42,;36.01,1.18,;36.01,2.72,;34.62,-4.3,;34.63,-5.85,;35.98,-3.57,;37.2,-4.46,;37.21,-6,;38.53,-6.78,;40.03,-6.44,;40.82,-7.75,;39.8,-8.91,;40,-10.44,;38.76,-11.36,;37.35,-10.75,;37.16,-9.24,;38.4,-8.3,;38.48,-3.59,;38.48,-2.04,;39.83,-4.31,;41.13,-3.51,;41.08,-1.97,;42.38,-1.17,;43.73,-1.9,;45.03,-1.09,;44.98,.44,;46.28,1.25,;43.62,1.16,;42.33,.35,;42.48,-4.23,;43.79,-3.42,;42.53,-5.76,)| Show InChI InChI=1S/C86H135N25O20/c1-11-13-21-56(103-81(127)63(37-44(3)4)107-79(125)60(30-33-67(90)114)105-85(131)70(46(7)12-2)111-80(126)61(31-34-68(115)116)101-74(120)49(10)99-84(130)69(45(5)6)110-72(118)47(8)88)76(122)109-65(40-52-42-94-43-97-52)83(129)104-59(29-32-66(89)113)78(124)102-57(24-17-19-36-95-86(92)93)75(121)98-48(9)73(119)100-58(23-16-18-35-87)77(123)108-64(39-51-41-96-55-22-15-14-20-54(51)55)82(128)106-62(71(91)117)38-50-25-27-53(112)28-26-50/h14-15,20,22,25-28,41-49,56-65,69-70,96,112H,11-13,16-19,21,23-24,29-40,87-88H2,1-10H3,(H2,89,113)(H2,90,114)(H2,91,117)(H,94,97)(H,98,121)(H,99,130)(H,100,119)(H,101,120)(H,102,124)(H,103,127)(H,104,129)(H,105,131)(H,106,128)(H,107,125)(H,108,123)(H,109,122)(H,110,118)(H,111,126)(H,115,116)(H4,92,93,95)/t46-,47-,48-,49-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,69-,70-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 26 | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Activity at human PTH/PTH-related peptide receptor expressed in HEK293 cells assessed as induction of luciferase activity by CRE-luciferase reporter ... |
Proc Natl Acad Sci U S A 104: 6846-51 (2007)
Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50269972
(Ala-Val-Ala-Glu-lle-Gln-Leu-Met-His-Gln-Har-Ala-Ly...)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1ccccc1-c1c2ccc(O)cc2oc2cc(=O)ccc12)C(N)=O |r,wU:4.4,44.43,60.59,79.79,26.27,96.96,17.17,119.121,wD:105.105,2.2,35.34,52.51,91.92,22.22,70.70,8.13,(4.06,-29.82,;4.08,-31.37,;5.42,-32.14,;6.75,-31.37,;5.42,-33.68,;4.2,-34.58,;2.86,-33.87,;2.86,-32.31,;1.59,-34.73,;1.59,-36.27,;2.91,-37.04,;2.91,-38.57,;1.59,-39.36,;4.24,-39.35,;.37,-33.83,;-.98,-34.56,;-.98,-36.11,;-2.26,-33.69,;-2.26,-32.15,;-3.5,-34.58,;-4.83,-33.85,;-4.82,-32.3,;-6.12,-34.72,;-7.33,-33.82,;-8.68,-34.55,;-8.68,-36.1,;-9.96,-33.68,;-9.96,-32.14,;-11.17,-34.57,;-6.12,-36.27,;-4.78,-37.03,;-7.44,-37.03,;6.7,-34.55,;6.7,-36.1,;8.06,-33.82,;9.27,-34.71,;9.27,-36.25,;10.61,-37.02,;10.61,-38.56,;9.27,-39.33,;11.93,-39.33,;10.54,-33.84,;10.55,-32.29,;11.91,-34.57,;13.13,-33.67,;13.13,-32.13,;14.46,-31.35,;14.46,-29.81,;15.79,-32.13,;14.4,-34.54,;14.4,-36.08,;15.76,-33.81,;16.96,-34.7,;16.96,-36.24,;18.3,-37.02,;18.3,-38.55,;19.63,-39.32,;18.24,-33.83,;18.26,-32.29,;19.61,-34.56,;20.83,-33.67,;20.83,-32.13,;22.16,-31.35,;23.63,-31.85,;24.54,-30.61,;23.65,-29.35,;22.18,-29.81,;22.11,-34.54,;22.11,-36.09,;23.46,-33.81,;24.68,-34.7,;24.68,-36.25,;26.01,-37.02,;26.01,-38.55,;24.68,-39.33,;27.35,-39.32,;25.96,-33.84,;25.97,-32.29,;27.33,-34.57,;28.54,-33.67,;28.55,-32.13,;29.88,-31.36,;29.88,-29.82,;31.21,-29.05,;31.21,-27.52,;32.54,-26.76,;32.54,-25.23,;33.86,-27.52,;29.82,-34.54,;29.82,-36.09,;31.18,-33.82,;32.39,-34.71,;32.39,-36.25,;33.67,-33.84,;33.67,-32.29,;35.03,-34.57,;36.25,-33.68,;36.25,-32.14,;37.59,-31.36,;37.59,-29.82,;38.91,-29.06,;38.91,-27.52,;37.53,-34.55,;37.54,-36.09,;38.89,-33.81,;40.11,-34.7,;40.11,-36.24,;41.44,-37.02,;42.94,-36.68,;43.73,-37.99,;42.71,-39.16,;42.9,-40.68,;41.67,-41.6,;40.25,-41,;40.07,-39.48,;41.3,-38.55,;41.38,-33.83,;41.39,-32.29,;42.74,-34.56,;44.06,-33.78,;44.05,-32.25,;42.72,-31.49,;42.71,-29.96,;41.38,-29.2,;41.36,-27.67,;42.66,-26.88,;44,-27.62,;42.63,-25.35,;41.1,-25.38,;40.3,-24.07,;41.05,-22.73,;42.58,-22.7,;43.37,-24.02,;44.89,-24,;45.64,-22.65,;44.85,-21.34,;45.6,-20,;47.14,-19.98,;47.88,-18.64,;47.92,-21.28,;47.19,-22.63,;47.98,-23.95,;47.22,-25.3,;48.01,-26.61,;47.25,-27.95,;48.03,-29.27,;45.72,-27.97,;44.93,-26.65,;45.68,-25.32,;45.39,-34.54,;45.4,-36.07,;46.72,-33.77,)| Show InChI InChI=1S/C102H146N26O23S/c1-11-54(6)85(128-96(145)73(35-38-82(133)134)119-89(138)57(9)116-100(149)84(53(4)5)127-87(136)55(7)104)101(150)123-72(34-37-81(106)132)94(143)124-75(44-52(2)3)97(146)122-74(39-43-152-10)95(144)126-77(46-59-50-110-51-114-59)99(148)121-71(33-36-80(105)131)93(142)120-69(28-18-21-42-112-102(108)109)91(140)115-56(8)88(137)118-70(27-16-19-40-103)92(141)125-76(45-58-49-113-67-25-15-14-22-62(58)67)98(147)117-68(86(107)135)26-17-20-41-111-90(139)64-24-13-12-23-63(64)83-65-31-29-60(129)47-78(65)151-79-48-61(130)30-32-66(79)83/h12-15,22-25,29-32,47-57,68-77,84-85,113,129H,11,16-21,26-28,33-46,103-104H2,1-10H3,(H2,105,131)(H2,106,132)(H2,107,135)(H,110,114)(H,111,139)(H,115,140)(H,116,149)(H,117,147)(H,118,137)(H,119,138)(H,120,142)(H,121,148)(H,122,146)(H,123,150)(H,124,143)(H,125,141)(H,126,144)(H,127,136)(H,128,145)(H,133,134)(H4,108,109,112)/t54-,55-,56-,57-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,84-,85-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 53 | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Activity at human PTH/PTH-related peptide receptor expressed in HEK293 cells assessed as induction of luciferase activity by CRE-luciferase reporter ... |
Proc Natl Acad Sci U S A 104: 6846-51 (2007)
Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50269974
(Ala-Val-Ala-Glu-lle-Gln-Leu-Nle-His-Gln-Har-Ala-Ly...)Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r,wU:79.79,25.25,47.48,60.59,8.12,38.38,96.96,wD:29.34,16.21,91.92,70.70,53.53,105.105,43.43,4.4,(19.79,-32.24,;18.45,-31.5,;18.43,-29.97,;17.09,-29.22,;17.07,-27.69,;15.77,-26.88,;14.41,-27.6,;14.41,-29.15,;13.14,-26.73,;13.14,-25.19,;14.47,-24.42,;14.47,-22.88,;15.8,-25.19,;11.92,-27.63,;10.55,-26.91,;10.56,-25.36,;9.28,-27.78,;9.28,-29.32,;10.62,-30.09,;10.62,-31.62,;9.28,-32.4,;11.94,-32.4,;8.07,-26.88,;6.71,-27.62,;6.71,-29.17,;5.43,-26.75,;4.22,-27.65,;2.86,-26.93,;2.87,-25.38,;1.59,-27.79,;1.59,-29.33,;2.92,-30.11,;2.92,-31.64,;1.59,-32.42,;4.25,-32.42,;.38,-26.9,;-.98,-27.63,;-.97,-29.17,;-2.25,-26.76,;-2.25,-25.22,;-3.47,-27.64,;-4.82,-26.91,;-4.82,-25.37,;-6.11,-27.78,;-7.32,-26.89,;-8.68,-27.62,;-8.67,-29.16,;-9.96,-26.75,;-9.96,-25.21,;-11.17,-27.64,;-6.11,-29.33,;-4.78,-30.1,;-7.44,-30.1,;5.43,-25.21,;6.76,-24.44,;4.09,-24.43,;4.08,-22.89,;18.25,-26.9,;18.27,-25.35,;19.62,-27.63,;20.84,-26.74,;20.84,-25.2,;22.17,-24.42,;23.64,-24.92,;24.55,-23.68,;23.66,-22.42,;22.19,-22.88,;22.12,-27.61,;22.12,-29.15,;23.47,-26.88,;24.69,-27.77,;24.69,-29.31,;26.02,-30.09,;26.02,-31.62,;24.69,-32.39,;27.36,-32.39,;25.97,-26.9,;25.98,-25.36,;27.34,-27.63,;28.55,-26.74,;28.55,-25.2,;29.89,-24.43,;29.89,-22.89,;31.22,-22.12,;31.22,-20.59,;32.54,-19.82,;32.54,-18.29,;33.87,-20.59,;29.83,-27.61,;29.83,-29.15,;31.19,-26.88,;32.4,-27.78,;32.4,-29.32,;33.68,-26.91,;33.68,-25.36,;35.04,-27.64,;36.26,-26.75,;36.26,-25.2,;37.59,-24.43,;37.6,-22.89,;38.92,-22.13,;38.92,-20.59,;37.54,-27.61,;37.55,-29.16,;38.9,-26.88,;40.24,-27.61,;40.27,-29.14,;41.61,-29.88,;41.64,-31.41,;42.98,-32.15,;44.29,-31.36,;45.63,-32.09,;44.25,-29.82,;42.91,-29.09,;41.55,-26.82,;42.89,-27.55,;41.52,-25.28,)| Show InChI InChI=1S/C75H125N23O19/c1-11-13-18-47(91-71(114)54(33-38(3)4)95-69(112)51(26-29-57(79)101)93-74(117)60(40(7)12-2)98-70(113)52(27-30-58(102)103)89-64(107)43(10)87-73(116)59(39(5)6)97-62(105)41(8)77)67(110)96-55(35-45-36-83-37-85-45)72(115)92-50(25-28-56(78)100)68(111)90-48(20-15-17-32-84-75(81)82)65(108)86-42(9)63(106)88-49(19-14-16-31-76)66(109)94-53(61(80)104)34-44-21-23-46(99)24-22-44/h21-24,36-43,47-55,59-60,99H,11-20,25-35,76-77H2,1-10H3,(H2,78,100)(H2,79,101)(H2,80,104)(H,83,85)(H,86,108)(H,87,116)(H,88,106)(H,89,107)(H,90,111)(H,91,114)(H,92,115)(H,93,117)(H,94,109)(H,95,112)(H,96,110)(H,97,105)(H,98,113)(H,102,103)(H4,81,82,84)/t40-,41-,42-,43-,47-,48-,49-,50-,51-,52-,53-,54-,55-,59-,60-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.43E+3 | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Activity at human PTH/PTH-related peptide receptor expressed in SAOS2 cells assessed as cAMP formation |
Proc Natl Acad Sci U S A 104: 6846-51 (2007)
Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50269976
(Aib-Val-Aib-Glu-lle-Gln-Leu-Nle-His-Gln-Arg-Ala-Ly...)Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)C(C)(C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r,wU:81.81,25.25,62.61,8.12,97.97,wD:16.21,92.93,72.72,55.55,106.106,4.4,44.44,29.34,(16.82,-7.68,;15.49,-6.94,;15.46,-5.4,;14.12,-4.66,;14.1,-3.13,;12.8,-2.32,;11.44,-3.04,;11.45,-4.59,;10.17,-2.17,;10.17,-.63,;11.5,.14,;11.51,1.68,;12.83,-.63,;8.95,-3.07,;7.59,-2.35,;7.59,-.8,;6.31,-3.21,;6.31,-4.76,;7.65,-5.53,;7.65,-7.06,;6.32,-7.84,;8.98,-7.84,;5.11,-2.32,;3.74,-3.06,;3.75,-4.6,;2.46,-2.19,;1.25,-3.09,;-.11,-2.37,;-.1,-.82,;-1.38,-3.23,;-1.38,-4.77,;-.05,-5.55,;-.05,-7.08,;-1.38,-7.86,;1.29,-7.86,;-2.59,-2.34,;-3.95,-3.07,;-3.94,-4.61,;-5.22,-2.2,;-4.41,-.9,;-6.06,-3.48,;-6.53,-1.45,;-6.57,.09,;-5.22,.85,;-7.96,.78,;-7.96,2.28,;-9.35,2.94,;-10.59,2.02,;-9.36,4.47,;-7.82,4.49,;-10.89,4.45,;-9.38,6.01,;-9.3,.01,;-9.31,-1.52,;-10.63,.79,;2.46,-.65,;3.8,.13,;1.13,.13,;1.11,1.67,;15.29,-2.34,;15.3,-.79,;16.65,-3.07,;17.87,-2.18,;17.87,-.63,;19.2,.14,;20.67,-.35,;21.59,.88,;20.7,2.14,;19.22,1.68,;19.15,-3.04,;19.16,-4.59,;20.51,-2.32,;21.72,-3.21,;21.73,-4.75,;23.05,-5.53,;23.05,-7.06,;21.73,-7.83,;24.4,-7.83,;23,-2.34,;23.01,-.79,;24.37,-3.07,;25.59,-2.18,;25.59,-.64,;26.92,.14,;26.93,1.68,;28.25,2.44,;28.25,3.97,;29.58,4.74,;26.93,4.74,;26.86,-3.05,;26.87,-4.59,;28.22,-2.32,;29.43,-3.21,;29.43,-4.76,;30.71,-2.35,;30.72,-.8,;32.08,-3.08,;33.29,-2.19,;33.3,-.64,;34.63,.13,;34.63,1.67,;35.96,2.44,;35.96,3.98,;34.58,-3.05,;34.58,-4.6,;35.93,-2.31,;37.28,-3.05,;37.31,-4.58,;38.65,-5.32,;38.67,-6.85,;40.01,-7.59,;41.33,-6.8,;42.67,-7.53,;41.29,-5.26,;39.95,-4.53,;38.59,-2.26,;39.93,-2.99,;38.56,-.72,)| Show InChI InChI=1S/C76H127N23O19/c1-13-15-19-46(90-68(113)53(34-39(3)4)94-66(111)50(27-30-56(79)102)92-70(115)59(41(7)14-2)97-67(112)51(28-31-57(103)104)96-73(118)76(11,12)99-71(116)58(40(5)6)98-72(117)75(9,10)83)64(109)95-54(36-44-37-84-38-86-44)69(114)91-49(26-29-55(78)101)65(110)89-48(21-18-33-85-74(81)82)62(107)87-42(8)61(106)88-47(20-16-17-32-77)63(108)93-52(60(80)105)35-43-22-24-45(100)25-23-43/h22-25,37-42,46-54,58-59,100H,13-21,26-36,77,83H2,1-12H3,(H2,78,101)(H2,79,102)(H2,80,105)(H,84,86)(H,87,107)(H,88,106)(H,89,110)(H,90,113)(H,91,114)(H,92,115)(H,93,108)(H,94,111)(H,95,109)(H,96,118)(H,97,112)(H,98,117)(H,99,116)(H,103,104)(H4,81,82,85)/t41-,42-,46-,47-,48-,49-,50-,51-,52-,53-,54-,58-,59-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 2.20 | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Activity at human PTH/PTH-related peptide receptor expressed in SAOS2 cells assessed as cAMP formation |
Proc Natl Acad Sci U S A 104: 6846-51 (2007)
Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50269977
(Aib-Val-Aib-Glu-lle-Gln-Leu-Nle-His-Gln-Arg-Ala-Ly...)Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)C(C)(C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCNC(=O)c1ccccc1-c1c2ccc(O)cc2oc2cc(=O)ccc12)C(N)=O |r,wU:62.61,8.12,97.97,81.81,25.25,118.119,wD:55.55,106.106,4.4,44.44,29.34,16.21,92.93,72.72,(16.67,-31.38,;15.33,-30.63,;15.31,-29.09,;13.97,-28.35,;13.94,-26.81,;12.64,-26,;11.27,-26.72,;11.28,-28.28,;10,-25.85,;10,-24.31,;11.34,-23.53,;11.34,-21.99,;12.67,-24.31,;8.78,-26.75,;7.41,-26.03,;7.42,-24.48,;6.13,-26.9,;6.14,-28.44,;7.47,-29.22,;7.47,-30.76,;6.14,-31.53,;8.8,-31.53,;4.92,-26,;3.55,-26.74,;3.56,-28.29,;2.27,-25.87,;1.05,-26.77,;-.3,-26.05,;-.3,-24.49,;-1.58,-26.92,;-1.58,-28.46,;-.25,-29.24,;-.25,-30.77,;-1.58,-31.56,;1.09,-31.56,;-2.8,-26.02,;-4.15,-26.75,;-4.15,-28.3,;-5.43,-25.88,;-4.62,-24.58,;-6.27,-27.16,;-6.75,-25.13,;-6.78,-23.59,;-5.43,-22.83,;-8.17,-22.89,;-8.18,-21.39,;-9.57,-20.73,;-10.82,-21.65,;-9.58,-19.19,;-8.04,-19.18,;-11.11,-19.21,;-9.6,-17.65,;-9.53,-23.66,;-9.53,-25.2,;-10.85,-22.88,;2.27,-24.33,;3.61,-23.55,;.93,-23.55,;.92,-22,;15.13,-26.02,;15.15,-24.47,;16.5,-26.75,;17.72,-25.86,;17.72,-24.31,;19.06,-23.53,;20.53,-24.03,;21.45,-22.79,;20.56,-21.53,;19.07,-21.99,;19.01,-26.73,;19.01,-28.28,;20.37,-26,;21.59,-26.89,;21.59,-28.44,;22.92,-29.21,;22.92,-30.75,;21.59,-31.53,;24.27,-31.53,;22.87,-26.02,;22.88,-24.47,;24.24,-26.75,;25.46,-25.86,;25.46,-24.31,;26.8,-23.54,;26.8,-21.99,;28.13,-21.23,;28.13,-19.69,;29.46,-18.92,;26.8,-18.92,;26.74,-26.73,;26.74,-28.28,;28.1,-26,;29.31,-26.9,;29.31,-28.44,;30.6,-26.03,;30.6,-24.48,;31.97,-26.76,;33.19,-25.87,;33.19,-24.32,;34.53,-23.54,;34.53,-22,;35.86,-21.23,;35.86,-19.69,;34.47,-26.74,;34.48,-28.29,;35.83,-26,;37.18,-26.73,;37.21,-28.27,;38.56,-29.01,;38.58,-30.54,;39.93,-31.28,;41.24,-30.49,;42.59,-31.23,;41.2,-28.95,;39.86,-28.21,;38.49,-25.94,;38.46,-24.4,;39.84,-26.67,;41.16,-25.89,;41.15,-24.36,;39.82,-23.6,;39.81,-22.06,;38.48,-21.3,;38.45,-19.76,;39.76,-18.97,;41.1,-19.72,;39.72,-17.44,;38.19,-17.47,;37.4,-16.15,;38.14,-14.8,;39.68,-14.78,;40.47,-16.1,;41.99,-16.08,;42.74,-14.73,;41.96,-13.41,;42.71,-12.07,;44.25,-12.05,;44.99,-10.71,;45.04,-13.36,;44.3,-14.71,;45.1,-16.03,;44.33,-17.38,;45.12,-18.7,;44.36,-20.05,;45.15,-21.37,;42.82,-20.07,;42.04,-18.74,;42.79,-17.4,;42.5,-26.65,;42.51,-28.19,;43.83,-25.88,)| Show InChI InChI=1S/C102H149N25O24/c1-13-15-25-67(118-93(144)73(46-53(3)4)121-91(142)71(38-41-79(105)132)120-96(147)83(55(7)14-2)125-92(143)72(39-42-80(133)134)124-99(150)102(11,12)127-97(148)82(54(5)6)126-98(149)101(9,10)109)88(139)123-75(48-58-51-110-52-113-58)95(146)119-70(37-40-78(104)131)90(141)117-69(28-22-45-112-100(107)108)87(138)114-56(8)85(136)116-68(27-18-20-43-103)89(140)122-74(47-57-29-31-59(128)32-30-57)94(145)115-66(84(106)135)26-19-21-44-111-86(137)63-24-17-16-23-62(63)81-64-35-33-60(129)49-76(64)151-77-50-61(130)34-36-65(77)81/h16-17,23-24,29-36,49-56,66-75,82-83,128-129H,13-15,18-22,25-28,37-48,103,109H2,1-12H3,(H2,104,131)(H2,105,132)(H2,106,135)(H,110,113)(H,111,137)(H,114,138)(H,115,145)(H,116,136)(H,117,141)(H,118,144)(H,119,146)(H,120,147)(H,121,142)(H,122,140)(H,123,139)(H,124,150)(H,125,143)(H,126,149)(H,127,148)(H,133,134)(H4,107,108,112)/t55-,56-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,82-,83-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 20 | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Activity at human PTH/PTH-related peptide receptor expressed in SAOS2 cells assessed as cAMP formation |
Proc Natl Acad Sci U S A 104: 6846-51 (2007)
Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50269978
(Aib-Val-Aib-Glu-lle-Gln-Leu-Nle-His-Gln-Arg-Ala-Fl...)Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)C(C)(C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCNC(=O)c1ccccc1-c1c2ccc(O)cc2oc2cc(=O)ccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r,wU:62.61,8.12,81.81,97.97,25.25,wD:55.55,44.44,4.4,29.34,92.93,72.72,130.134,16.21,(17.08,-55.29,;15.74,-54.54,;15.72,-53,;14.37,-52.25,;14.35,-50.72,;13.05,-49.9,;11.68,-50.63,;11.69,-52.18,;10.41,-49.76,;10.41,-48.21,;11.75,-47.44,;11.75,-45.89,;13.08,-48.22,;9.18,-50.66,;7.82,-49.93,;7.82,-48.38,;6.54,-50.81,;6.54,-52.35,;7.88,-53.13,;7.88,-54.66,;6.54,-55.44,;9.21,-55.44,;5.33,-49.91,;3.96,-50.65,;3.97,-52.2,;2.68,-49.78,;1.46,-50.68,;.1,-49.96,;.11,-48.4,;-1.17,-50.82,;-1.17,-52.37,;.16,-53.14,;.16,-54.68,;-1.17,-55.47,;1.5,-55.47,;-2.39,-49.93,;-3.75,-50.66,;-3.74,-52.21,;-5.02,-49.78,;-4.21,-48.48,;-5.88,-51.07,;-6.33,-49.03,;-6.37,-47.49,;-5.03,-46.73,;-7.78,-46.8,;-7.77,-45.29,;-9.18,-44.63,;-10.4,-45.56,;-9.17,-43.1,;-7.63,-43.08,;-10.7,-43.12,;-9.19,-41.56,;-9.11,-47.57,;-9.14,-49.11,;-10.44,-46.79,;2.68,-48.23,;4.02,-47.46,;1.34,-47.45,;1.33,-45.91,;15.54,-49.93,;15.55,-48.38,;16.91,-50.66,;18.13,-49.76,;18.13,-48.22,;19.47,-47.44,;20.94,-47.94,;21.86,-46.7,;20.97,-45.43,;19.48,-45.89,;19.42,-50.64,;19.42,-52.19,;20.78,-49.91,;22,-50.8,;22,-52.35,;23.33,-53.12,;23.33,-54.66,;22,-55.44,;24.68,-55.43,;23.28,-49.93,;23.29,-48.38,;24.65,-50.66,;25.87,-49.77,;25.87,-48.22,;27.21,-47.45,;27.21,-45.9,;28.54,-45.13,;28.54,-43.6,;29.87,-42.83,;27.21,-42.83,;27.15,-50.64,;27.15,-52.19,;28.51,-49.91,;29.72,-50.81,;29.73,-52.35,;31.01,-49.93,;31.01,-48.38,;32.36,-50.66,;33.68,-49.87,;33.68,-48.34,;32.34,-47.58,;32.33,-46.04,;31,-45.28,;30.97,-43.74,;32.28,-42.95,;33.63,-43.7,;32.25,-41.42,;30.72,-41.45,;29.92,-40.13,;30.67,-38.78,;32.2,-38.76,;32.99,-40.08,;34.52,-40.06,;35.27,-38.71,;34.48,-37.39,;35.23,-36.05,;36.77,-36.03,;37.52,-34.69,;37.56,-37.34,;36.82,-38.69,;37.62,-40.01,;36.85,-41.36,;37.65,-42.68,;36.89,-44.03,;37.67,-45.35,;35.35,-44.05,;34.56,-42.72,;35.31,-41.38,;35.02,-50.64,;35.03,-52.17,;36.35,-49.86,;37.68,-50.62,;37.69,-52.15,;39.03,-52.92,;39.02,-54.45,;40.36,-55.21,;41.69,-54.44,;43.02,-55.2,;41.67,-52.89,;40.34,-52.14,;39.01,-49.84,;40.34,-50.6,;39,-48.31,)| Show InChI InChI=1S/C96H137N23O23/c1-13-15-23-62(110-88(136)69(42-49(3)4)114-86(134)66(35-38-74(98)124)112-90(138)78(51(7)14-2)117-87(135)67(36-39-75(125)126)116-93(141)96(11,12)119-91(139)77(50(5)6)118-92(140)95(9,10)102)84(132)115-70(44-54-47-103-48-106-54)89(137)111-65(34-37-73(97)123)85(133)109-64(25-20-41-105-94(100)101)82(130)107-52(8)80(128)108-63(83(131)113-68(79(99)127)43-53-26-28-55(120)29-27-53)24-18-19-40-104-81(129)59-22-17-16-21-58(59)76-60-32-30-56(121)45-71(60)142-72-46-57(122)31-33-61(72)76/h16-17,21-22,26-33,45-52,62-70,77-78,120-121H,13-15,18-20,23-25,34-44,102H2,1-12H3,(H2,97,123)(H2,98,124)(H2,99,127)(H,103,106)(H,104,129)(H,107,130)(H,108,128)(H,109,133)(H,110,136)(H,111,137)(H,112,138)(H,113,131)(H,114,134)(H,115,132)(H,116,141)(H,117,135)(H,118,140)(H,119,139)(H,125,126)(H4,100,101,105)/t51-,52-,62-,63-,64-,65-,66-,67-,68-,69-,70-,77-,78-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 7.20 | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Activity at human PTH/PTH-related peptide receptor expressed in SAOS2 cells assessed as cAMP formation |
Proc Natl Acad Sci U S A 104: 6846-51 (2007)
Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50269976
(Aib-Val-Aib-Glu-lle-Gln-Leu-Nle-His-Gln-Arg-Ala-Ly...)Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)C(C)(C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r,wU:81.81,25.25,62.61,8.12,97.97,wD:16.21,92.93,72.72,55.55,106.106,4.4,44.44,29.34,(16.82,-7.68,;15.49,-6.94,;15.46,-5.4,;14.12,-4.66,;14.1,-3.13,;12.8,-2.32,;11.44,-3.04,;11.45,-4.59,;10.17,-2.17,;10.17,-.63,;11.5,.14,;11.51,1.68,;12.83,-.63,;8.95,-3.07,;7.59,-2.35,;7.59,-.8,;6.31,-3.21,;6.31,-4.76,;7.65,-5.53,;7.65,-7.06,;6.32,-7.84,;8.98,-7.84,;5.11,-2.32,;3.74,-3.06,;3.75,-4.6,;2.46,-2.19,;1.25,-3.09,;-.11,-2.37,;-.1,-.82,;-1.38,-3.23,;-1.38,-4.77,;-.05,-5.55,;-.05,-7.08,;-1.38,-7.86,;1.29,-7.86,;-2.59,-2.34,;-3.95,-3.07,;-3.94,-4.61,;-5.22,-2.2,;-4.41,-.9,;-6.06,-3.48,;-6.53,-1.45,;-6.57,.09,;-5.22,.85,;-7.96,.78,;-7.96,2.28,;-9.35,2.94,;-10.59,2.02,;-9.36,4.47,;-7.82,4.49,;-10.89,4.45,;-9.38,6.01,;-9.3,.01,;-9.31,-1.52,;-10.63,.79,;2.46,-.65,;3.8,.13,;1.13,.13,;1.11,1.67,;15.29,-2.34,;15.3,-.79,;16.65,-3.07,;17.87,-2.18,;17.87,-.63,;19.2,.14,;20.67,-.35,;21.59,.88,;20.7,2.14,;19.22,1.68,;19.15,-3.04,;19.16,-4.59,;20.51,-2.32,;21.72,-3.21,;21.73,-4.75,;23.05,-5.53,;23.05,-7.06,;21.73,-7.83,;24.4,-7.83,;23,-2.34,;23.01,-.79,;24.37,-3.07,;25.59,-2.18,;25.59,-.64,;26.92,.14,;26.93,1.68,;28.25,2.44,;28.25,3.97,;29.58,4.74,;26.93,4.74,;26.86,-3.05,;26.87,-4.59,;28.22,-2.32,;29.43,-3.21,;29.43,-4.76,;30.71,-2.35,;30.72,-.8,;32.08,-3.08,;33.29,-2.19,;33.3,-.64,;34.63,.13,;34.63,1.67,;35.96,2.44,;35.96,3.98,;34.58,-3.05,;34.58,-4.6,;35.93,-2.31,;37.28,-3.05,;37.31,-4.58,;38.65,-5.32,;38.67,-6.85,;40.01,-7.59,;41.33,-6.8,;42.67,-7.53,;41.29,-5.26,;39.95,-4.53,;38.59,-2.26,;39.93,-2.99,;38.56,-.72,)| Show InChI InChI=1S/C76H127N23O19/c1-13-15-19-46(90-68(113)53(34-39(3)4)94-66(111)50(27-30-56(79)102)92-70(115)59(41(7)14-2)97-67(112)51(28-31-57(103)104)96-73(118)76(11,12)99-71(116)58(40(5)6)98-72(117)75(9,10)83)64(109)95-54(36-44-37-84-38-86-44)69(114)91-49(26-29-55(78)101)65(110)89-48(21-18-33-85-74(81)82)62(107)87-42(8)61(106)88-47(20-16-17-32-77)63(108)93-52(60(80)105)35-43-22-24-45(100)25-23-43/h22-25,37-42,46-54,58-59,100H,13-21,26-36,77,83H2,1-12H3,(H2,78,101)(H2,79,102)(H2,80,105)(H,84,86)(H,87,107)(H,88,106)(H,89,110)(H,90,113)(H,91,114)(H,92,115)(H,93,108)(H,94,111)(H,95,109)(H,96,118)(H,97,112)(H,98,117)(H,99,116)(H,103,104)(H4,81,82,85)/t41-,42-,46-,47-,48-,49-,50-,51-,52-,53-,54-,58-,59-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | 21.6 | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity to PTH/PTH-related peptide receptor (unknown origin) expressed in HKRK-B28 cells |
Proc Natl Acad Sci U S A 104: 6846-51 (2007)
Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50269976
(Aib-Val-Aib-Glu-lle-Gln-Leu-Nle-His-Gln-Arg-Ala-Ly...)Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)C(C)(C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r,wU:81.81,25.25,62.61,8.12,97.97,wD:16.21,92.93,72.72,55.55,106.106,4.4,44.44,29.34,(16.82,-7.68,;15.49,-6.94,;15.46,-5.4,;14.12,-4.66,;14.1,-3.13,;12.8,-2.32,;11.44,-3.04,;11.45,-4.59,;10.17,-2.17,;10.17,-.63,;11.5,.14,;11.51,1.68,;12.83,-.63,;8.95,-3.07,;7.59,-2.35,;7.59,-.8,;6.31,-3.21,;6.31,-4.76,;7.65,-5.53,;7.65,-7.06,;6.32,-7.84,;8.98,-7.84,;5.11,-2.32,;3.74,-3.06,;3.75,-4.6,;2.46,-2.19,;1.25,-3.09,;-.11,-2.37,;-.1,-.82,;-1.38,-3.23,;-1.38,-4.77,;-.05,-5.55,;-.05,-7.08,;-1.38,-7.86,;1.29,-7.86,;-2.59,-2.34,;-3.95,-3.07,;-3.94,-4.61,;-5.22,-2.2,;-4.41,-.9,;-6.06,-3.48,;-6.53,-1.45,;-6.57,.09,;-5.22,.85,;-7.96,.78,;-7.96,2.28,;-9.35,2.94,;-10.59,2.02,;-9.36,4.47,;-7.82,4.49,;-10.89,4.45,;-9.38,6.01,;-9.3,.01,;-9.31,-1.52,;-10.63,.79,;2.46,-.65,;3.8,.13,;1.13,.13,;1.11,1.67,;15.29,-2.34,;15.3,-.79,;16.65,-3.07,;17.87,-2.18,;17.87,-.63,;19.2,.14,;20.67,-.35,;21.59,.88,;20.7,2.14,;19.22,1.68,;19.15,-3.04,;19.16,-4.59,;20.51,-2.32,;21.72,-3.21,;21.73,-4.75,;23.05,-5.53,;23.05,-7.06,;21.73,-7.83,;24.4,-7.83,;23,-2.34,;23.01,-.79,;24.37,-3.07,;25.59,-2.18,;25.59,-.64,;26.92,.14,;26.93,1.68,;28.25,2.44,;28.25,3.97,;29.58,4.74,;26.93,4.74,;26.86,-3.05,;26.87,-4.59,;28.22,-2.32,;29.43,-3.21,;29.43,-4.76,;30.71,-2.35,;30.72,-.8,;32.08,-3.08,;33.29,-2.19,;33.3,-.64,;34.63,.13,;34.63,1.67,;35.96,2.44,;35.96,3.98,;34.58,-3.05,;34.58,-4.6,;35.93,-2.31,;37.28,-3.05,;37.31,-4.58,;38.65,-5.32,;38.67,-6.85,;40.01,-7.59,;41.33,-6.8,;42.67,-7.53,;41.29,-5.26,;39.95,-4.53,;38.59,-2.26,;39.93,-2.99,;38.56,-.72,)| Show InChI InChI=1S/C76H127N23O19/c1-13-15-19-46(90-68(113)53(34-39(3)4)94-66(111)50(27-30-56(79)102)92-70(115)59(41(7)14-2)97-67(112)51(28-31-57(103)104)96-73(118)76(11,12)99-71(116)58(40(5)6)98-72(117)75(9,10)83)64(109)95-54(36-44-37-84-38-86-44)69(114)91-49(26-29-55(78)101)65(110)89-48(21-18-33-85-74(81)82)62(107)87-42(8)61(106)88-47(20-16-17-32-77)63(108)93-52(60(80)105)35-43-22-24-45(100)25-23-43/h22-25,37-42,46-54,58-59,100H,13-21,26-36,77,83H2,1-12H3,(H2,78,101)(H2,79,102)(H2,80,105)(H,84,86)(H,87,107)(H,88,106)(H,89,110)(H,90,113)(H,91,114)(H,92,115)(H,93,108)(H,94,111)(H,95,109)(H,96,118)(H,97,112)(H,98,117)(H,99,116)(H,103,104)(H4,81,82,85)/t41-,42-,46-,47-,48-,49-,50-,51-,52-,53-,54-,58-,59-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 26 | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Activity at human PTH/PTH-related peptide receptor expressed in HEK293 cells assessed as induction of intracellular calcium mobilization |
Proc Natl Acad Sci U S A 104: 6846-51 (2007)
Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50269971
(Ala-Val-Ala-Glu-lle-Gln-Leu-Met-His-Gln-Har-Ala-Ly...)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O |r,wU:26.27,96.96,17.17,4.4,44.43,60.59,79.79,wD:70.70,8.13,105.105,2.2,35.34,52.51,91.92,22.22,(5.02,-.01,;5.03,-1.56,;6.37,-2.33,;7.7,-1.56,;6.37,-3.87,;5.16,-4.77,;3.8,-4.05,;3.81,-2.5,;2.53,-4.91,;2.53,-6.45,;3.86,-7.22,;3.86,-8.75,;2.53,-9.53,;5.19,-9.53,;1.32,-4.02,;-.03,-4.74,;-.03,-6.29,;-1.3,-3.88,;-1.3,-2.34,;-2.53,-4.76,;-3.88,-4.03,;-3.87,-2.49,;-5.16,-4.9,;-6.37,-4.01,;-7.72,-4.74,;-7.72,-6.28,;-9,-3.87,;-9,-2.33,;-10.21,-4.76,;-5.16,-6.45,;-3.83,-7.21,;-6.49,-7.21,;7.64,-4.74,;7.65,-6.28,;9.01,-4,;10.21,-4.89,;10.22,-6.43,;11.55,-7.21,;11.55,-8.74,;10.22,-9.51,;12.87,-9.51,;11.49,-4.03,;11.49,-2.48,;12.85,-4.75,;14.06,-3.85,;14.06,-2.31,;15.4,-1.54,;15.4,-0,;16.72,-2.31,;15.33,-4.72,;15.34,-6.26,;16.7,-4,;17.9,-4.88,;17.9,-6.42,;19.23,-7.2,;19.23,-8.73,;20.56,-9.5,;19.18,-4.02,;19.19,-2.47,;20.54,-4.75,;21.76,-3.86,;21.76,-2.32,;23.09,-1.54,;24.56,-2.04,;25.47,-.8,;24.58,.46,;23.1,-0,;23.03,-4.72,;23.04,-6.27,;24.39,-4,;25.61,-4.89,;25.61,-6.43,;26.93,-7.2,;26.93,-8.73,;25.61,-9.5,;28.27,-9.5,;26.88,-4.02,;26.89,-2.48,;28.25,-4.75,;29.46,-3.86,;29.47,-2.32,;30.8,-1.55,;30.8,-.01,;32.12,.76,;32.12,2.28,;33.45,3.05,;33.45,4.58,;34.77,2.28,;30.74,-4.73,;30.74,-6.27,;32.1,-4,;33.3,-4.89,;33.3,-6.43,;34.58,-4.03,;34.59,-2.48,;35.95,-4.76,;37.16,-3.86,;37.16,-2.32,;38.5,-1.55,;38.5,-.01,;39.82,.75,;39.82,2.29,;38.44,-4.73,;38.45,-6.28,;39.79,-3.99,;41.02,-4.88,;41.02,-6.42,;42.34,-7.2,;43.84,-6.86,;44.63,-8.17,;43.61,-9.33,;43.81,-10.86,;42.58,-11.78,;41.16,-11.17,;40.98,-9.66,;42.21,-8.73,;42.29,-4.02,;43.64,-4.74,;42.29,-2.47,)| Show InChI InChI=1S/C76H124N24O18S/c1-11-40(6)61(100-71(114)52(24-27-59(103)104)91-65(108)43(9)89-74(117)60(39(4)5)99-63(106)41(7)78)75(118)95-51(23-26-58(80)102)69(112)97-55(32-38(2)3)72(115)94-53(28-31-119-10)70(113)98-56(34-45-36-84-37-87-45)73(116)93-50(22-25-57(79)101)68(111)92-48(21-15-17-30-85-76(82)83)66(109)88-42(8)64(107)90-49(20-14-16-29-77)67(110)96-54(62(81)105)33-44-35-86-47-19-13-12-18-46(44)47/h12-13,18-19,35-43,48-56,60-61,86H,11,14-17,20-34,77-78H2,1-10H3,(H2,79,101)(H2,80,102)(H2,81,105)(H,84,87)(H,88,109)(H,89,117)(H,90,107)(H,91,108)(H,92,111)(H,93,116)(H,94,115)(H,95,118)(H,96,110)(H,97,112)(H,98,113)(H,99,106)(H,100,114)(H,103,104)(H4,82,83,85)/t40-,41-,42-,43-,48-,49-,50-,51-,52-,53-,54-,55-,56-,60-,61-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 32 | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Activity at human PTH/PTH-related peptide receptor expressed in HEK293 cells assessed as induction of luciferase activity by CRE-luciferase reporter ... |
Proc Natl Acad Sci U S A 104: 6846-51 (2007)
Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Rattus norvegicus (Rat)) | BDBM50269971
(Ala-Val-Ala-Glu-lle-Gln-Leu-Met-His-Gln-Har-Ala-Ly...)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O |r,wU:26.27,96.96,17.17,4.4,44.43,60.59,79.79,wD:70.70,8.13,105.105,2.2,35.34,52.51,91.92,22.22,(5.02,-.01,;5.03,-1.56,;6.37,-2.33,;7.7,-1.56,;6.37,-3.87,;5.16,-4.77,;3.8,-4.05,;3.81,-2.5,;2.53,-4.91,;2.53,-6.45,;3.86,-7.22,;3.86,-8.75,;2.53,-9.53,;5.19,-9.53,;1.32,-4.02,;-.03,-4.74,;-.03,-6.29,;-1.3,-3.88,;-1.3,-2.34,;-2.53,-4.76,;-3.88,-4.03,;-3.87,-2.49,;-5.16,-4.9,;-6.37,-4.01,;-7.72,-4.74,;-7.72,-6.28,;-9,-3.87,;-9,-2.33,;-10.21,-4.76,;-5.16,-6.45,;-3.83,-7.21,;-6.49,-7.21,;7.64,-4.74,;7.65,-6.28,;9.01,-4,;10.21,-4.89,;10.22,-6.43,;11.55,-7.21,;11.55,-8.74,;10.22,-9.51,;12.87,-9.51,;11.49,-4.03,;11.49,-2.48,;12.85,-4.75,;14.06,-3.85,;14.06,-2.31,;15.4,-1.54,;15.4,-0,;16.72,-2.31,;15.33,-4.72,;15.34,-6.26,;16.7,-4,;17.9,-4.88,;17.9,-6.42,;19.23,-7.2,;19.23,-8.73,;20.56,-9.5,;19.18,-4.02,;19.19,-2.47,;20.54,-4.75,;21.76,-3.86,;21.76,-2.32,;23.09,-1.54,;24.56,-2.04,;25.47,-.8,;24.58,.46,;23.1,-0,;23.03,-4.72,;23.04,-6.27,;24.39,-4,;25.61,-4.89,;25.61,-6.43,;26.93,-7.2,;26.93,-8.73,;25.61,-9.5,;28.27,-9.5,;26.88,-4.02,;26.89,-2.48,;28.25,-4.75,;29.46,-3.86,;29.47,-2.32,;30.8,-1.55,;30.8,-.01,;32.12,.76,;32.12,2.28,;33.45,3.05,;33.45,4.58,;34.77,2.28,;30.74,-4.73,;30.74,-6.27,;32.1,-4,;33.3,-4.89,;33.3,-6.43,;34.58,-4.03,;34.59,-2.48,;35.95,-4.76,;37.16,-3.86,;37.16,-2.32,;38.5,-1.55,;38.5,-.01,;39.82,.75,;39.82,2.29,;38.44,-4.73,;38.45,-6.28,;39.79,-3.99,;41.02,-4.88,;41.02,-6.42,;42.34,-7.2,;43.84,-6.86,;44.63,-8.17,;43.61,-9.33,;43.81,-10.86,;42.58,-11.78,;41.16,-11.17,;40.98,-9.66,;42.21,-8.73,;42.29,-4.02,;43.64,-4.74,;42.29,-2.47,)| Show InChI InChI=1S/C76H124N24O18S/c1-11-40(6)61(100-71(114)52(24-27-59(103)104)91-65(108)43(9)89-74(117)60(39(4)5)99-63(106)41(7)78)75(118)95-51(23-26-58(80)102)69(112)97-55(32-38(2)3)72(115)94-53(28-31-119-10)70(113)98-56(34-45-36-84-37-87-45)73(116)93-50(22-25-57(79)101)68(111)92-48(21-15-17-30-85-76(82)83)66(109)88-42(8)64(107)90-49(20-14-16-29-77)67(110)96-54(62(81)105)33-44-35-86-47-19-13-12-18-46(44)47/h12-13,18-19,35-43,48-56,60-61,86H,11,14-17,20-34,77-78H2,1-10H3,(H2,79,101)(H2,80,102)(H2,81,105)(H,84,87)(H,88,109)(H,89,117)(H,90,107)(H,91,108)(H,92,111)(H,93,116)(H,94,115)(H,95,118)(H,96,110)(H,97,112)(H,98,113)(H,99,106)(H,100,114)(H,103,104)(H4,82,83,85)/t40-,41-,42-,43-,48-,49-,50-,51-,52-,53-,54-,55-,56-,60-,61-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 155 | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Activity at rat PTH/PTH-related peptide receptor expressed in rat UMR106 cells assessed as cAMP formation |
Proc Natl Acad Sci U S A 104: 6846-51 (2007)
Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V |
More data for this
Ligand-Target Pair | |
Parathyroid hormone/parathyroid hormone-related peptide receptor
(Homo sapiens (Human)) | BDBM50269971
(Ala-Val-Ala-Glu-lle-Gln-Leu-Met-His-Gln-Har-Ala-Ly...)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O |r,wU:26.27,96.96,17.17,4.4,44.43,60.59,79.79,wD:70.70,8.13,105.105,2.2,35.34,52.51,91.92,22.22,(5.02,-.01,;5.03,-1.56,;6.37,-2.33,;7.7,-1.56,;6.37,-3.87,;5.16,-4.77,;3.8,-4.05,;3.81,-2.5,;2.53,-4.91,;2.53,-6.45,;3.86,-7.22,;3.86,-8.75,;2.53,-9.53,;5.19,-9.53,;1.32,-4.02,;-.03,-4.74,;-.03,-6.29,;-1.3,-3.88,;-1.3,-2.34,;-2.53,-4.76,;-3.88,-4.03,;-3.87,-2.49,;-5.16,-4.9,;-6.37,-4.01,;-7.72,-4.74,;-7.72,-6.28,;-9,-3.87,;-9,-2.33,;-10.21,-4.76,;-5.16,-6.45,;-3.83,-7.21,;-6.49,-7.21,;7.64,-4.74,;7.65,-6.28,;9.01,-4,;10.21,-4.89,;10.22,-6.43,;11.55,-7.21,;11.55,-8.74,;10.22,-9.51,;12.87,-9.51,;11.49,-4.03,;11.49,-2.48,;12.85,-4.75,;14.06,-3.85,;14.06,-2.31,;15.4,-1.54,;15.4,-0,;16.72,-2.31,;15.33,-4.72,;15.34,-6.26,;16.7,-4,;17.9,-4.88,;17.9,-6.42,;19.23,-7.2,;19.23,-8.73,;20.56,-9.5,;19.18,-4.02,;19.19,-2.47,;20.54,-4.75,;21.76,-3.86,;21.76,-2.32,;23.09,-1.54,;24.56,-2.04,;25.47,-.8,;24.58,.46,;23.1,-0,;23.03,-4.72,;23.04,-6.27,;24.39,-4,;25.61,-4.89,;25.61,-6.43,;26.93,-7.2,;26.93,-8.73,;25.61,-9.5,;28.27,-9.5,;26.88,-4.02,;26.89,-2.48,;28.25,-4.75,;29.46,-3.86,;29.47,-2.32,;30.8,-1.55,;30.8,-.01,;32.12,.76,;32.12,2.28,;33.45,3.05,;33.45,4.58,;34.77,2.28,;30.74,-4.73,;30.74,-6.27,;32.1,-4,;33.3,-4.89,;33.3,-6.43,;34.58,-4.03,;34.59,-2.48,;35.95,-4.76,;37.16,-3.86,;37.16,-2.32,;38.5,-1.55,;38.5,-.01,;39.82,.75,;39.82,2.29,;38.44,-4.73,;38.45,-6.28,;39.79,-3.99,;41.02,-4.88,;41.02,-6.42,;42.34,-7.2,;43.84,-6.86,;44.63,-8.17,;43.61,-9.33,;43.81,-10.86,;42.58,-11.78,;41.16,-11.17,;40.98,-9.66,;42.21,-8.73,;42.29,-4.02,;43.64,-4.74,;42.29,-2.47,)| Show InChI InChI=1S/C76H124N24O18S/c1-11-40(6)61(100-71(114)52(24-27-59(103)104)91-65(108)43(9)89-74(117)60(39(4)5)99-63(106)41(7)78)75(118)95-51(23-26-58(80)102)69(112)97-55(32-38(2)3)72(115)94-53(28-31-119-10)70(113)98-56(34-45-36-84-37-87-45)73(116)93-50(22-25-57(79)101)68(111)92-48(21-15-17-30-85-76(82)83)66(109)88-42(8)64(107)90-49(20-14-16-29-77)67(110)96-54(62(81)105)33-44-35-86-47-19-13-12-18-46(44)47/h12-13,18-19,35-43,48-56,60-61,86H,11,14-17,20-34,77-78H2,1-10H3,(H2,79,101)(H2,80,102)(H2,81,105)(H,84,87)(H,88,109)(H,89,117)(H,90,107)(H,91,108)(H,92,111)(H,93,116)(H,94,115)(H,95,118)(H,96,110)(H,97,112)(H,98,113)(H,99,106)(H,100,114)(H,103,104)(H4,82,83,85)/t40-,41-,42-,43-,48-,49-,50-,51-,52-,53-,54-,55-,56-,60-,61-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 800 | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Activity at human PTH/PTH-related peptide receptor expressed in SAOS2 cells assessed as cAMP formation |
Proc Natl Acad Sci U S A 104: 6846-51 (2007)
Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V |
More data for this
Ligand-Target Pair | |
Search and Browse
