Compile Data Set for Download or QSAR

Found 82 hits Enz. Inhib. hit(s) with all data for entry = 50030472   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 1 (RAT)	BDBM50296674 ((E)-1-Adamantan-1-yl-3-quinolin-3-yl-propenone | C...) Show SMILES O=C(\C=C\c1cnc2ccccc2c1)C12CC3CC(CC(C3)C1)C2 |THB:19:18:15:21.20.22,19:20:17.18.23:15,1:14:17:21.19.20,22:20:17:23.14.15,22:14:17:21.19.20| Show InChI InChI=1S/C22H23NO/c24-21(22-11-16-7-17(12-22)9-18(8-16)13-22)6-5-15-10-19-3-1-2-4-20(19)23-14-15/h1-6,10,14,16-18H,7-9,11-13H2/b6-5+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	21	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...				Bioorg Med Chem 17: 5708-15 (2009) Article DOI: 10.1016/j.bmc.2009.05.072 BindingDB Entry DOI: 10.7270/Q2416X30
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50296665 (Adamantan-1-yl-[2-(6-morpholin-4-yl-2-pyridin-3-yl...) Show SMILES O=C(C1CC1c1ccc(nc1)N1CCOCC1)C12CC3CC(CC(C3)C1)C2 |THB:1:17:20:24.22.23,22:21:18:24.23.25,22:23:20.21.26:18,25:23:20:26.17.18,25:17:20:24.22.23| Show InChI InChI=1S/C23H30N2O2/c26-22(23-11-15-7-16(12-23)9-17(8-15)13-23)20-10-19(20)18-1-2-21(24-14-18)25-3-5-27-6-4-25/h1-2,14-17,19-20H,3-13H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	24	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...				Bioorg Med Chem 17: 5708-15 (2009) Article DOI: 10.1016/j.bmc.2009.05.072 BindingDB Entry DOI: 10.7270/Q2416X30
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50296665 (Adamantan-1-yl-[2-(6-morpholin-4-yl-2-pyridin-3-yl...) Show SMILES O=C(C1CC1c1ccc(nc1)N1CCOCC1)C12CC3CC(CC(C3)C1)C2 |THB:1:17:20:24.22.23,22:21:18:24.23.25,22:23:20.21.26:18,25:23:20:26.17.18,25:17:20:24.22.23| Show InChI InChI=1S/C23H30N2O2/c26-22(23-11-15-7-16(12-23)9-17(8-15)13-23)20-10-19(20)18-1-2-21(24-14-18)25-3-5-27-6-4-25/h1-2,14-17,19-20H,3-13H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	110	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Binding affinity to human GluR1 by FLIPR assay				Bioorg Med Chem 17: 5708-15 (2009) Article DOI: 10.1016/j.bmc.2009.05.072 BindingDB Entry DOI: 10.7270/Q2416X30
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50296677 (Adamantan-1-yl-(2-quinolin-3-yl-cyclopropyl)-metha...) Show SMILES O=C(C1CC1c1cnc2ccccc2c1)C12CC3CC(CC(C3)C1)C2 |THB:20:19:16:22.21.23,20:21:18.19.24:16,1:15:18:22.20.21,23:21:18:24.15.16,23:15:18:22.20.21| Show InChI InChI=1S/C23H25NO/c25-22(23-10-14-5-15(11-23)7-16(6-14)12-23)20-9-19(20)18-8-17-3-1-2-4-21(17)24-13-18/h1-4,8,13-16,19-20H,5-7,9-12H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	137	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...				Bioorg Med Chem 17: 5708-15 (2009) Article DOI: 10.1016/j.bmc.2009.05.072 BindingDB Entry DOI: 10.7270/Q2416X30
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50296676 ((E)-1-Adamantan-1-yl-3-(4-methoxy-3-methyl-phenyl)...) Show SMILES COc1ncc(\C=C\C(=O)C23CC4CC(CC(C4)C2)C3)cc1C |THB:8:10:13:17.15.16,15:14:11:17.16.18,15:16:13.14.19:11,18:16:13:19.10.11,18:10:13:17.15.16| Show InChI InChI=1S/C20H25NO2/c1-13-5-14(12-21-19(13)23-2)3-4-18(22)20-9-15-6-16(10-20)8-17(7-15)11-20/h3-5,12,15-17H,6-11H2,1-2H3/b4-3+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	294	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...				Bioorg Med Chem 17: 5708-15 (2009) Article DOI: 10.1016/j.bmc.2009.05.072 BindingDB Entry DOI: 10.7270/Q2416X30
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50296679 (Adamantan-1-yl-[2-(6-methoxy-pyridin-3-yl)-cyclopr...) Show SMILES COc1ccc(cn1)C1CC1C(=O)C12CC3CC(CC(C3)C1)C2 |THB:11:13:16:20.18.19,18:17:14:20.19.21,18:19:16.17.22:14,21:19:16:22.13.14,21:13:16:20.18.19| Show InChI InChI=1S/C20H25NO2/c1-23-18-3-2-15(11-21-18)16-7-17(16)19(22)20-8-12-4-13(9-20)6-14(5-12)10-20/h2-3,11-14,16-17H,4-10H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	304	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...				Bioorg Med Chem 17: 5708-15 (2009) Article DOI: 10.1016/j.bmc.2009.05.072 BindingDB Entry DOI: 10.7270/Q2416X30
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50296675 ((E)-1-Adamantan-1-yl-3-(2,3-dihydro-benzo[1,4]diox...) Show SMILES O=C(\C=C\c1cnc2OCCOc2c1)C12CC3CC(CC(C3)C1)C2 |THB:1:14:17:21.19.20,19:18:15:21.20.22,19:20:17.18.23:15,22:20:17:23.14.15,22:14:17:21.19.20| Show InChI InChI=1S/C20H23NO3/c22-18(20-9-14-5-15(10-20)7-16(6-14)11-20)2-1-13-8-17-19(21-12-13)24-4-3-23-17/h1-2,8,12,14-16H,3-7,9-11H2/b2-1+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	641	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...				Bioorg Med Chem 17: 5708-15 (2009) Article DOI: 10.1016/j.bmc.2009.05.072 BindingDB Entry DOI: 10.7270/Q2416X30
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50296674 ((E)-1-Adamantan-1-yl-3-quinolin-3-yl-propenone | C...) Show SMILES O=C(\C=C\c1cnc2ccccc2c1)C12CC3CC(CC(C3)C1)C2 |THB:19:18:15:21.20.22,19:20:17.18.23:15,1:14:17:21.19.20,22:20:17:23.14.15,22:14:17:21.19.20| Show InChI InChI=1S/C22H23NO/c24-21(22-11-16-7-17(12-22)9-18(8-16)13-22)6-5-15-10-19-3-1-2-4-20(19)23-14-15/h1-6,10,14,16-18H,7-9,11-13H2/b6-5+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	807	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Displacement of [3H]MPEP from mGluR5 in rat cortical membrane after 60 mins by liquid scintillation counting				Bioorg Med Chem 17: 5708-15 (2009) Article DOI: 10.1016/j.bmc.2009.05.072 BindingDB Entry DOI: 10.7270/Q2416X30
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50296676 ((E)-1-Adamantan-1-yl-3-(4-methoxy-3-methyl-phenyl)...) Show SMILES COc1ncc(\C=C\C(=O)C23CC4CC(CC(C4)C2)C3)cc1C |THB:8:10:13:17.15.16,15:14:11:17.16.18,15:16:13.14.19:11,18:16:13:19.10.11,18:10:13:17.15.16| Show InChI InChI=1S/C20H25NO2/c1-13-5-14(12-21-19(13)23-2)3-4-18(22)20-9-15-6-16(10-20)8-17(7-15)11-20/h3-5,12,15-17H,6-11H2,1-2H3/b4-3+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	5.15E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Displacement of [3H]MPEP from mGluR5 in rat cortical membrane after 60 mins by liquid scintillation counting				Bioorg Med Chem 17: 5708-15 (2009) Article DOI: 10.1016/j.bmc.2009.05.072 BindingDB Entry DOI: 10.7270/Q2416X30
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50296673 ((E)-4,4-Dimethyl-1-quinolin-3-yl-pent-1-en-3-one |...) Show SMILES CC(C)(C)C(=O)\C=C\c1cnc2ccccc2c1 Show InChI InChI=1S/C16H17NO/c1-16(2,3)15(18)9-8-12-10-13-6-4-5-7-14(13)17-11-12/h4-11H,1-3H3/b9-8+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	5.23E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...				Bioorg Med Chem 17: 5708-15 (2009) Article DOI: 10.1016/j.bmc.2009.05.072 BindingDB Entry DOI: 10.7270/Q2416X30
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50296675 ((E)-1-Adamantan-1-yl-3-(2,3-dihydro-benzo[1,4]diox...) Show SMILES O=C(\C=C\c1cnc2OCCOc2c1)C12CC3CC(CC(C3)C1)C2 |THB:1:14:17:21.19.20,19:18:15:21.20.22,19:20:17.18.23:15,22:20:17:23.14.15,22:14:17:21.19.20| Show InChI InChI=1S/C20H23NO3/c22-18(20-9-14-5-15(10-20)7-16(6-14)11-20)2-1-13-8-17-19(21-12-13)24-4-3-23-17/h1-2,8,12,14-16H,3-7,9-11H2/b2-1+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	6.23E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Displacement of [3H]MPEP from mGluR5 in rat cortical membrane after 60 mins by liquid scintillation counting				Bioorg Med Chem 17: 5708-15 (2009) Article DOI: 10.1016/j.bmc.2009.05.072 BindingDB Entry DOI: 10.7270/Q2416X30
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50296678 (Adamantan-1-yl-(2-pyridin-3-yl-cyclopropyl)-methan...) Show SMILES O=C(C1CC1c1cccnc1)C12CC3CC(CC(C3)C1)C2 |THB:1:11:14:18.16.17,16:15:12:18.17.19,16:17:14.15.20:12,19:17:14:20.11.12,19:11:14:18.16.17| Show InChI InChI=1S/C19H23NO/c21-18(17-7-16(17)15-2-1-3-20-11-15)19-8-12-4-13(9-19)6-14(5-12)10-19/h1-3,11-14,16-17H,4-10H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	7.04E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...				Bioorg Med Chem 17: 5708-15 (2009) Article DOI: 10.1016/j.bmc.2009.05.072 BindingDB Entry DOI: 10.7270/Q2416X30
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50296668 (3-(2-chloro-6-methylquinolin-3-yl)-1-phenylprop-2-...) Show SMILES Cc1ccc2nc(Cl)c(\C=C\C(=O)c3ccccc3)cc2c1 Show InChI InChI=1S/C19H14ClNO/c1-13-7-9-17-16(11-13)12-15(19(20)21-17)8-10-18(22)14-5-3-2-4-6-14/h2-12H,1H3/b10-8+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	9.18E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...				Bioorg Med Chem 17: 5708-15 (2009) Article DOI: 10.1016/j.bmc.2009.05.072 BindingDB Entry DOI: 10.7270/Q2416X30
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50296666 (3-(2-chloro-6-methylquinolin-3-yl)-1-(thiophen-2-y...) Show SMILES Cc1ccc2nc(Cl)c(\C=C\C(=O)c3cccs3)cc2c1 Show InChI InChI=1S/C17H12ClNOS/c1-11-4-6-14-13(9-11)10-12(17(18)19-14)5-7-15(20)16-3-2-8-21-16/h2-10H,1H3/b7-5+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	9.93E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...				Bioorg Med Chem 17: 5708-15 (2009) Article DOI: 10.1016/j.bmc.2009.05.072 BindingDB Entry DOI: 10.7270/Q2416X30
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50296669 (3-(2-chloro-7-methylquinolin-3-yl)-1-(thiophen-2-y...) Show SMILES Cc1ccc2cc(\C=C\C(=O)c3cccs3)c(Cl)nc2c1 Show InChI InChI=1S/C17H12ClNOS/c1-11-4-5-12-10-13(17(18)19-14(12)9-11)6-7-15(20)16-3-2-8-21-16/h2-10H,1H3/b7-6+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.72E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...				Bioorg Med Chem 17: 5708-15 (2009) Article DOI: 10.1016/j.bmc.2009.05.072 BindingDB Entry DOI: 10.7270/Q2416X30
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50296679 (Adamantan-1-yl-[2-(6-methoxy-pyridin-3-yl)-cyclopr...) Show SMILES COc1ccc(cn1)C1CC1C(=O)C12CC3CC(CC(C3)C1)C2 |THB:11:13:16:20.18.19,18:17:14:20.19.21,18:19:16.17.22:14,21:19:16:22.13.14,21:13:16:20.18.19| Show InChI InChI=1S/C20H25NO2/c1-23-18-3-2-15(11-21-18)16-7-17(16)19(22)20-8-12-4-13(9-20)6-14(5-12)10-20/h2-3,11-14,16-17H,4-10H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	1.84E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Displacement of [3H]MPEP from mGluR5 in rat cortical membrane after 60 mins by liquid scintillation counting				Bioorg Med Chem 17: 5708-15 (2009) Article DOI: 10.1016/j.bmc.2009.05.072 BindingDB Entry DOI: 10.7270/Q2416X30
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50296678 (Adamantan-1-yl-(2-pyridin-3-yl-cyclopropyl)-methan...) Show SMILES O=C(C1CC1c1cccnc1)C12CC3CC(CC(C3)C1)C2 |THB:1:11:14:18.16.17,16:15:12:18.17.19,16:17:14.15.20:12,19:17:14:20.11.12,19:11:14:18.16.17| Show InChI InChI=1S/C19H23NO/c21-18(17-7-16(17)15-2-1-3-20-11-15)19-8-12-4-13(9-19)6-14(5-12)10-19/h1-3,11-14,16-17H,4-10H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.29E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Displacement of [3H]MPEP from mGluR5 in rat cortical membrane after 60 mins by liquid scintillation counting				Bioorg Med Chem 17: 5708-15 (2009) Article DOI: 10.1016/j.bmc.2009.05.072 BindingDB Entry DOI: 10.7270/Q2416X30
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50296665 (Adamantan-1-yl-[2-(6-morpholin-4-yl-2-pyridin-3-yl...) Show SMILES O=C(C1CC1c1ccc(nc1)N1CCOCC1)C12CC3CC(CC(C3)C1)C2 |THB:1:17:20:24.22.23,22:21:18:24.23.25,22:23:20.21.26:18,25:23:20:26.17.18,25:17:20:24.22.23| Show InChI InChI=1S/C23H30N2O2/c26-22(23-11-15-7-16(12-23)9-17(8-15)13-23)20-10-19(20)18-1-2-21(24-14-18)25-3-5-27-6-4-25/h1-2,14-17,19-20H,3-13H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	2.78E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Displacement of [3H]MPEP from mGluR5 in rat cortical membrane after 60 mins by liquid scintillation counting				Bioorg Med Chem 17: 5708-15 (2009) Article DOI: 10.1016/j.bmc.2009.05.072 BindingDB Entry DOI: 10.7270/Q2416X30
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50296673 ((E)-4,4-Dimethyl-1-quinolin-3-yl-pent-1-en-3-one |...) Show SMILES CC(C)(C)C(=O)\C=C\c1cnc2ccccc2c1 Show InChI InChI=1S/C16H17NO/c1-16(2,3)15(18)9-8-12-10-13-6-4-5-7-14(13)17-11-12/h4-11H,1-3H3/b9-8+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	3.06E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Displacement of [3H]MPEP from mGluR5 in rat cortical membrane after 60 mins by liquid scintillation counting				Bioorg Med Chem 17: 5708-15 (2009) Article DOI: 10.1016/j.bmc.2009.05.072 BindingDB Entry DOI: 10.7270/Q2416X30
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50296700 (1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-phenylbu...) Show SMILES CC(CC(=O)c1ccc2OCCOc2c1)c1ccccc1 Show InChI InChI=1S/C18H18O3/c1-13(14-5-3-2-4-6-14)11-16(19)15-7-8-17-18(12-15)21-10-9-20-17/h2-8,12-13H,9-11H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.62E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...				Bioorg Med Chem 17: 5708-15 (2009) Article DOI: 10.1016/j.bmc.2009.05.072 BindingDB Entry DOI: 10.7270/Q2416X30
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50296671 (3-(2-chloro-7-methylquinolin-3-yl)-1-(2,4-dimethyl...) Show SMILES Cc1coc(C)c1C(=O)C=Cc1cc2ccc(C)cc2nc1Cl |w:10.11| Show InChI InChI=1S/C19H16ClNO2/c1-11-4-5-14-9-15(19(20)21-16(14)8-11)6-7-17(22)18-12(2)10-23-13(18)3/h4-10H,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...				Bioorg Med Chem 17: 5708-15 (2009) Article DOI: 10.1016/j.bmc.2009.05.072 BindingDB Entry DOI: 10.7270/Q2416X30
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50296670 (3-(2-chloro-6-methylquinolin-3-yl)-1-(4-methoxyphe...) Show SMILES COc1ccc(cc1)C(=O)\C=C\c1cc2cc(C)ccc2nc1Cl Show InChI InChI=1S/C20H16ClNO2/c1-13-3-9-18-16(11-13)12-15(20(21)22-18)6-10-19(23)14-4-7-17(24-2)8-5-14/h3-12H,1-2H3/b10-6+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...				Bioorg Med Chem 17: 5708-15 (2009) Article DOI: 10.1016/j.bmc.2009.05.072 BindingDB Entry DOI: 10.7270/Q2416X30
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50296689 ((4-(4-bromobenzylideneamino)phenyl)(phenyl)methano...) Show SMILES Brc1ccc(\C=N\c2ccc(cc2)C(=O)c2ccccc2)cc1 Show InChI InChI=1S/C20H14BrNO/c21-18-10-6-15(7-11-18)14-22-19-12-8-17(9-13-19)20(23)16-4-2-1-3-5-16/h1-14H/b22-14+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...				Bioorg Med Chem 17: 5708-15 (2009) Article DOI: 10.1016/j.bmc.2009.05.072 BindingDB Entry DOI: 10.7270/Q2416X30
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50296667 (3-(2-chloro-8-methylquinolin-3-yl)-1-phenylprop-2-...) Show SMILES Cc1cccc2cc(\C=C\C(=O)c3ccccc3)c(Cl)nc12 Show InChI InChI=1S/C19H14ClNO/c1-13-6-5-9-15-12-16(19(20)21-18(13)15)10-11-17(22)14-7-3-2-4-8-14/h2-12H,1H3/b11-10+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...				Bioorg Med Chem 17: 5708-15 (2009) Article DOI: 10.1016/j.bmc.2009.05.072 BindingDB Entry DOI: 10.7270/Q2416X30
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50296680 (4-acetylphenyl biphenyl-4-carboxylate | CHEMBL5619...) Show SMILES CC(=O)c1ccc(OC(=O)c2ccc(cc2)-c2ccccc2)cc1 Show InChI InChI=1S/C21H16O3/c1-15(22)16-11-13-20(14-12-16)24-21(23)19-9-7-18(8-10-19)17-5-3-2-4-6-17/h2-14H,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...				Bioorg Med Chem 17: 5708-15 (2009) Article DOI: 10.1016/j.bmc.2009.05.072 BindingDB Entry DOI: 10.7270/Q2416X30
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50296699 (3-(4-(2,4-dichlorobenzyloxy)phenyl)-1-(4-ethoxyphe...) Show SMILES CCOc1ccc(cc1)C(=O)\C=C\c1ccc(OCc2ccc(Cl)cc2Cl)cc1 Show InChI InChI=1S/C24H20Cl2O3/c1-2-28-21-12-7-18(8-13-21)24(27)14-5-17-3-10-22(11-4-17)29-16-19-6-9-20(25)15-23(19)26/h3-15H,2,16H2,1H3/b14-5+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...				Bioorg Med Chem 17: 5708-15 (2009) Article DOI: 10.1016/j.bmc.2009.05.072 BindingDB Entry DOI: 10.7270/Q2416X30
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50296698 (2,4-bis(3-bromo-4-methoxyphenyl)-6-methylpyridine ...) Show SMILES COc1ccc(cc1Br)-c1cc(C)nc(c1)-c1ccc(OC)c(Br)c1 Show InChI InChI=1S/C20H17Br2NO2/c1-12-8-15(13-4-6-19(24-2)16(21)9-13)11-18(23-12)14-5-7-20(25-3)17(22)10-14/h4-11H,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...				Bioorg Med Chem 17: 5708-15 (2009) Article DOI: 10.1016/j.bmc.2009.05.072 BindingDB Entry DOI: 10.7270/Q2416X30
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50296697 ((4-chlorophenyl)(2,3,4,5-tetrahydrobenzo[b]oxepin-...) Show SMILES Clc1ccc(cc1)C(=O)c1ccc2OCCCCc2c1 Show InChI InChI=1S/C17H15ClO2/c18-15-7-4-12(5-8-15)17(19)14-6-9-16-13(11-14)3-1-2-10-20-16/h4-9,11H,1-3,10H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...				Bioorg Med Chem 17: 5708-15 (2009) Article DOI: 10.1016/j.bmc.2009.05.072 BindingDB Entry DOI: 10.7270/Q2416X30
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50296696 (2-(biphenyl-4-yl)-5-(4-butoxyphenyl)-1,3,4-thiadia...) Show SMILES CCCCOc1ccc(cc1)-c1nnc(s1)-c1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C24H22N2OS/c1-2-3-17-27-22-15-13-21(14-16-22)24-26-25-23(28-24)20-11-9-19(10-12-20)18-7-5-4-6-8-18/h4-16H,2-3,17H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...				Bioorg Med Chem 17: 5708-15 (2009) Article DOI: 10.1016/j.bmc.2009.05.072 BindingDB Entry DOI: 10.7270/Q2416X30
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50296695 (CHEMBL537963 | N-((9-ethyl-9H-carbazol-3-yl)methyl...) Show SMILES CCn1c2ccccc2c2cc(\C=N\c3ccc(C)c(F)c3)ccc12 Show InChI InChI=1S/C22H19FN2/c1-3-25-21-7-5-4-6-18(21)19-12-16(9-11-22(19)25)14-24-17-10-8-15(2)20(23)13-17/h4-14H,3H2,1-2H3/b24-14+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...				Bioorg Med Chem 17: 5708-15 (2009) Article DOI: 10.1016/j.bmc.2009.05.072 BindingDB Entry DOI: 10.7270/Q2416X30
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50296694 (1-benzyl-6,7-dimethoxy-3,3-dimethyl-3,4-dihydroiso...) Show SMILES COc1cc2CC(C)(C)N=C(Cc3ccccc3)c2cc1OC |t:9| Show InChI InChI=1S/C20H23NO2/c1-20(2)13-15-11-18(22-3)19(23-4)12-16(15)17(21-20)10-14-8-6-5-7-9-14/h5-9,11-12H,10,13H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...				Bioorg Med Chem 17: 5708-15 (2009) Article DOI: 10.1016/j.bmc.2009.05.072 BindingDB Entry DOI: 10.7270/Q2416X30
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50296693 (6-chloro-7-(4-fluorobenzyloxy)-4-phenyl-2H-chromen...) Show SMILES Fc1ccc(COc2cc3oc(=O)cc(-c4ccccc4)c3cc2Cl)cc1 Show InChI InChI=1S/C22H14ClFO3/c23-19-10-18-17(15-4-2-1-3-5-15)11-22(25)27-20(18)12-21(19)26-13-14-6-8-16(24)9-7-14/h1-12H,13H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...				Bioorg Med Chem 17: 5708-15 (2009) Article DOI: 10.1016/j.bmc.2009.05.072 BindingDB Entry DOI: 10.7270/Q2416X30
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50296664 (3-(2-chloro-7-methylquinolin-3-yl)-1-(4-methoxyphe...) Show SMILES COc1ccc(cc1)C(=O)\C=C\c1cc2ccc(C)cc2nc1Cl Show InChI InChI=1S/C20H16ClNO2/c1-13-3-4-15-12-16(20(21)22-18(15)11-13)7-10-19(23)14-5-8-17(24-2)9-6-14/h3-12H,1-2H3/b10-7+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...				Bioorg Med Chem 17: 5708-15 (2009) Article DOI: 10.1016/j.bmc.2009.05.072 BindingDB Entry DOI: 10.7270/Q2416X30
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50296681 (4-acetylphenyl 4-butylcyclohexanecarboxylate | CHE...) Show SMILES CCCCC1CCC(CC1)C(=O)Oc1ccc(cc1)C(C)=O |(37.89,-30.99,;36.55,-30.24,;35.23,-31.03,;33.88,-30.27,;32.56,-31.06,;32.58,-32.61,;31.25,-33.4,;29.91,-32.64,;29.89,-31.09,;31.22,-30.31,;28.58,-33.42,;27.24,-32.66,;28.59,-34.96,;27.26,-35.74,;25.93,-34.97,;24.61,-35.75,;24.62,-37.29,;25.97,-38.05,;27.29,-37.27,;23.29,-38.08,;23.31,-39.62,;21.95,-37.32,)| Show InChI InChI=1S/C19H26O3/c1-3-4-5-15-6-8-17(9-7-15)19(21)22-18-12-10-16(11-13-18)14(2)20/h10-13,15,17H,3-9H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...				Bioorg Med Chem 17: 5708-15 (2009) Article DOI: 10.1016/j.bmc.2009.05.072 BindingDB Entry DOI: 10.7270/Q2416X30
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50296688 (4-cyclohexylphenyl 4-(hexyloxy)benzoate | CHEMBL56...) Show SMILES CCCCCCOc1ccc(cc1)C(=O)Oc1ccc(cc1)C1CCCCC1 Show InChI InChI=1S/C25H32O3/c1-2-3-4-8-19-27-23-15-13-22(14-16-23)25(26)28-24-17-11-21(12-18-24)20-9-6-5-7-10-20/h11-18,20H,2-10,19H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...				Bioorg Med Chem 17: 5708-15 (2009) Article DOI: 10.1016/j.bmc.2009.05.072 BindingDB Entry DOI: 10.7270/Q2416X30
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50296686 (7-(3-phenoxybenzyloxy)-4-phenyl-2H-chromen-2-one |...) Show SMILES O=c1cc(-c2ccccc2)c2ccc(OCc3cccc(Oc4ccccc4)c3)cc2o1 Show InChI InChI=1S/C28H20O4/c29-28-18-26(21-9-3-1-4-10-21)25-15-14-23(17-27(25)32-28)30-19-20-8-7-13-24(16-20)31-22-11-5-2-6-12-22/h1-18H,19H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...				Bioorg Med Chem 17: 5708-15 (2009) Article DOI: 10.1016/j.bmc.2009.05.072 BindingDB Entry DOI: 10.7270/Q2416X30
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50296682 (8-hexyl-7-methoxy-2,3-dihydrocyclopenta[c]chromen-...) Show SMILES CCCCCCc1cc2c3CCCc3c(=O)oc2cc1OC Show InChI InChI=1S/C19H24O3/c1-3-4-5-6-8-13-11-16-14-9-7-10-15(14)19(20)22-18(16)12-17(13)21-2/h11-12H,3-10H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...				Bioorg Med Chem 17: 5708-15 (2009) Article DOI: 10.1016/j.bmc.2009.05.072 BindingDB Entry DOI: 10.7270/Q2416X30
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50296683 (4-(5-pentylpyridin-2-yl)phenyl 4-ethylcyclohexanec...) Show SMILES CCCCCc1ccc(nc1)-c1ccc(OC(=O)C2CCC(CC)CC2)cc1 |(3.83,-46.98,;5.37,-46.96,;6.12,-45.61,;7.66,-45.59,;8.41,-44.24,;9.95,-44.22,;10.7,-42.87,;12.24,-42.84,;13.04,-44.16,;12.29,-45.51,;10.74,-45.54,;14.57,-44.13,;15.36,-45.45,;16.9,-45.42,;17.65,-44.08,;19.19,-44.05,;19.98,-45.36,;21.52,-45.33,;19.24,-46.71,;17.7,-46.73,;16.96,-48.08,;17.75,-49.4,;17,-50.74,;15.46,-50.77,;19.29,-49.37,;20.04,-48.02,;16.84,-42.75,;15.31,-42.79,)| Show InChI InChI=1S/C25H33NO2/c1-3-5-6-7-20-10-17-24(26-18-20)21-13-15-23(16-14-21)28-25(27)22-11-8-19(4-2)9-12-22/h10,13-19,22H,3-9,11-12H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...				Bioorg Med Chem 17: 5708-15 (2009) Article DOI: 10.1016/j.bmc.2009.05.072 BindingDB Entry DOI: 10.7270/Q2416X30
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50296684 (3-(1-phenylethoxy)-6H-benzo[c]chromen-6-one | CHEM...) Show SMILES CC(Oc1ccc2c(c1)oc(=O)c1ccccc21)c1ccccc1 Show InChI InChI=1S/C21H16O3/c1-14(15-7-3-2-4-8-15)23-16-11-12-18-17-9-5-6-10-19(17)21(22)24-20(18)13-16/h2-14H,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...				Bioorg Med Chem 17: 5708-15 (2009) Article DOI: 10.1016/j.bmc.2009.05.072 BindingDB Entry DOI: 10.7270/Q2416X30
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50296685 ((3,4-dimethylphenyl)(4-phenoxyphenyl)methanone | C...) Show SMILES Cc1ccc(cc1C)C(=O)c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C21H18O2/c1-15-8-9-18(14-16(15)2)21(22)17-10-12-20(13-11-17)23-19-6-4-3-5-7-19/h3-14H,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...				Bioorg Med Chem 17: 5708-15 (2009) Article DOI: 10.1016/j.bmc.2009.05.072 BindingDB Entry DOI: 10.7270/Q2416X30
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50296687 (1-(4-methoxyphenyl)-3-(4-(thietan-3-yloxy)phenyl)p...) Show SMILES COc1ccc(cc1)C(=O)\C=C\c1ccc(OC2CSC2)cc1 Show InChI InChI=1S/C19H18O3S/c1-21-16-9-5-15(6-10-16)19(20)11-4-14-2-7-17(8-3-14)22-18-12-23-13-18/h2-11,18H,12-13H2,1H3/b11-4+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...				Bioorg Med Chem 17: 5708-15 (2009) Article DOI: 10.1016/j.bmc.2009.05.072 BindingDB Entry DOI: 10.7270/Q2416X30
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50296690 (7-(4-fluorobenzyloxy)-4-phenyl-2H-chromen-2-one | ...) Show SMILES Fc1ccc(COc2ccc3c(cc(=O)oc3c2)-c2ccccc2)cc1 Show InChI InChI=1S/C22H15FO3/c23-17-8-6-15(7-9-17)14-25-18-10-11-19-20(16-4-2-1-3-5-16)13-22(24)26-21(19)12-18/h1-13H,14H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...				Bioorg Med Chem 17: 5708-15 (2009) Article DOI: 10.1016/j.bmc.2009.05.072 BindingDB Entry DOI: 10.7270/Q2416X30
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50296691 (3-(4-chlorophenyl)-1-(4-phenoxyphenyl)prop-2-en-1-...) Show SMILES Clc1ccc(\C=C\C(=O)c2ccc(Oc3ccccc3)cc2)cc1 Show InChI InChI=1S/C21H15ClO2/c22-18-11-6-16(7-12-18)8-15-21(23)17-9-13-20(14-10-17)24-19-4-2-1-3-5-19/h1-15H/b15-8+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...				Bioorg Med Chem 17: 5708-15 (2009) Article DOI: 10.1016/j.bmc.2009.05.072 BindingDB Entry DOI: 10.7270/Q2416X30
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50296692 ((4-(4-methoxy-3-methylbenzoyl)phenyl)(3-methoxy-4-...) Show SMILES COc1ccc(cc1C)C(=O)c1ccc(cc1)C(=O)c1ccc(C)c(OC)c1 Show InChI InChI=1S/C24H22O4/c1-15-5-6-20(14-22(15)28-4)24(26)18-9-7-17(8-10-18)23(25)19-11-12-21(27-3)16(2)13-19/h5-14H,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...				Bioorg Med Chem 17: 5708-15 (2009) Article DOI: 10.1016/j.bmc.2009.05.072 BindingDB Entry DOI: 10.7270/Q2416X30
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50296668 (3-(2-chloro-6-methylquinolin-3-yl)-1-phenylprop-2-...) Show SMILES Cc1ccc2nc(Cl)c(\C=C\C(=O)c3ccccc3)cc2c1 Show InChI InChI=1S/C19H14ClNO/c1-13-7-9-17-16(11-13)12-15(19(20)21-17)8-10-18(22)14-5-3-2-4-6-14/h2-12H,1H3/b10-8+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Displacement of [3H]MPEP from mGluR5 in rat cortical membrane after 60 mins by liquid scintillation counting				Bioorg Med Chem 17: 5708-15 (2009) Article DOI: 10.1016/j.bmc.2009.05.072 BindingDB Entry DOI: 10.7270/Q2416X30
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50296667 (3-(2-chloro-8-methylquinolin-3-yl)-1-phenylprop-2-...) Show SMILES Cc1cccc2cc(\C=C\C(=O)c3ccccc3)c(Cl)nc12 Show InChI InChI=1S/C19H14ClNO/c1-13-6-5-9-15-12-16(19(20)21-18(13)15)10-11-17(22)14-7-3-2-4-8-14/h2-12H,1H3/b11-10+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Displacement of [3H]MPEP from mGluR5 in rat cortical membrane after 60 mins by liquid scintillation counting				Bioorg Med Chem 17: 5708-15 (2009) Article DOI: 10.1016/j.bmc.2009.05.072 BindingDB Entry DOI: 10.7270/Q2416X30
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50296677 (Adamantan-1-yl-(2-quinolin-3-yl-cyclopropyl)-metha...) Show SMILES O=C(C1CC1c1cnc2ccccc2c1)C12CC3CC(CC(C3)C1)C2 |THB:20:19:16:22.21.23,20:21:18.19.24:16,1:15:18:22.20.21,23:21:18:24.15.16,23:15:18:22.20.21| Show InChI InChI=1S/C23H25NO/c25-22(23-10-14-5-15(11-23)7-16(6-14)12-23)20-9-19(20)18-8-17-3-1-2-4-21(17)24-13-18/h1-4,8,13-16,19-20H,5-7,9-12H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Displacement of [3H]MPEP from mGluR5 in rat cortical membrane after 60 mins by liquid scintillation counting				Bioorg Med Chem 17: 5708-15 (2009) Article DOI: 10.1016/j.bmc.2009.05.072 BindingDB Entry DOI: 10.7270/Q2416X30
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50296672 ((E)-1-Cyclopropyl-3-quinolin-3-yl-propenone | CHEM...) Show SMILES O=C(C=Cc1cnc2ccccc2c1)C1CC1 |w:3.3| Show InChI InChI=1S/C15H13NO/c17-15(12-6-7-12)8-5-11-9-13-3-1-2-4-14(13)16-10-11/h1-5,8-10,12H,6-7H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Displacement of [3H]MPEP from mGluR5 in rat cortical membrane after 60 mins by liquid scintillation counting				Bioorg Med Chem 17: 5708-15 (2009) Article DOI: 10.1016/j.bmc.2009.05.072 BindingDB Entry DOI: 10.7270/Q2416X30
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50296672 ((E)-1-Cyclopropyl-3-quinolin-3-yl-propenone | CHEM...) Show SMILES O=C(C=Cc1cnc2ccccc2c1)C1CC1 |w:3.3| Show InChI InChI=1S/C15H13NO/c17-15(12-6-7-12)8-5-11-9-13-3-1-2-4-14(13)16-10-11/h1-5,8-10,12H,6-7H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b...				Bioorg Med Chem 17: 5708-15 (2009) Article DOI: 10.1016/j.bmc.2009.05.072 BindingDB Entry DOI: 10.7270/Q2416X30
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50296664 (3-(2-chloro-7-methylquinolin-3-yl)-1-(4-methoxyphe...) Show SMILES COc1ccc(cc1)C(=O)\C=C\c1cc2ccc(C)cc2nc1Cl Show InChI InChI=1S/C20H16ClNO2/c1-13-3-4-15-12-16(20(21)22-18(15)11-13)7-10-19(23)14-5-8-17(24-2)9-6-14/h3-12H,1-2H3/b10-7+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Displacement of [3H]MPEP from mGluR5 in rat cortical membrane after 60 mins by liquid scintillation counting				Bioorg Med Chem 17: 5708-15 (2009) Article DOI: 10.1016/j.bmc.2009.05.072 BindingDB Entry DOI: 10.7270/Q2416X30
					More data for this Ligand-Target Pair

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