Found 29 hits Enz. Inhib. hit(s) with all data for entry = 50010480 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Dual specificity mitogen-activated protein kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50095232
(6-Methoxy-7-(3-morpholin-4-yl-propoxy)-4-(4-phenox...)Show SMILES COc1cc2c(Nc3ccc(Oc4ccccc4)cc3)c(cnc2cc1OCCCN1CCOCC1)C#N Show InChI InChI=1S/C30H30N4O4/c1-35-28-18-26-27(19-29(28)37-15-5-12-34-13-16-36-17-14-34)32-21-22(20-31)30(26)33-23-8-10-25(11-9-23)38-24-6-3-2-4-7-24/h2-4,6-11,18-19,21H,5,12-17H2,1H3,(H,32,33) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research
Curated by ChEMBL
| Assay Description Inhibition of ERK-phosphorylation by Raf-MEK-ERK in coupled ELISA |
Bioorg Med Chem Lett 10: 2825-8 (2000)
BindingDB Entry DOI: 10.7270/Q22N51J8 |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50095232
(6-Methoxy-7-(3-morpholin-4-yl-propoxy)-4-(4-phenox...)Show SMILES COc1cc2c(Nc3ccc(Oc4ccccc4)cc3)c(cnc2cc1OCCCN1CCOCC1)C#N Show InChI InChI=1S/C30H30N4O4/c1-35-28-18-26-27(19-29(28)37-15-5-12-34-13-16-36-17-14-34)32-21-22(20-31)30(26)33-23-8-10-25(11-9-23)38-24-6-3-2-4-7-24/h2-4,6-11,18-19,21H,5,12-17H2,1H3,(H,32,33) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research
Curated by ChEMBL
| Assay Description Inhibition of ERK-phosphorylation by MEK-ERK in direct ELISA |
Bioorg Med Chem Lett 10: 2825-8 (2000)
BindingDB Entry DOI: 10.7270/Q22N51J8 |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50095235
(6-Methoxy-7-(2-morpholin-4-yl-ethoxy)-4-(4-phenoxy...)Show SMILES COc1cc2c(Nc3ccc(Oc4ccccc4)cc3)c(cnc2cc1OCCN1CCOCC1)C#N Show InChI InChI=1S/C29H28N4O4/c1-34-27-17-25-26(18-28(27)36-16-13-33-11-14-35-15-12-33)31-20-21(19-30)29(25)32-22-7-9-24(10-8-22)37-23-5-3-2-4-6-23/h2-10,17-18,20H,11-16H2,1H3,(H,31,32) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research
Curated by ChEMBL
| Assay Description Inhibition of ERK-phosphorylation by Raf-MEK-ERK in coupled ELISA |
Bioorg Med Chem Lett 10: 2825-8 (2000)
BindingDB Entry DOI: 10.7270/Q22N51J8 |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50095226
(6,7-Dimethoxy-4-(4-phenoxy-phenylamino)-quinoline-...)Show SMILES COc1cc2ncc(C#N)c(Nc3ccc(Oc4ccccc4)cc3)c2cc1OC Show InChI InChI=1S/C24H19N3O3/c1-28-22-12-20-21(13-23(22)29-2)26-15-16(14-25)24(20)27-17-8-10-19(11-9-17)30-18-6-4-3-5-7-18/h3-13,15H,1-2H3,(H,26,27) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research
Curated by ChEMBL
| Assay Description Inhibition of ERK-phosphorylation by Raf-MEK-ERK in coupled ELISA |
Bioorg Med Chem Lett 10: 2825-8 (2000)
BindingDB Entry DOI: 10.7270/Q22N51J8 |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50095236
(6-Methoxy-4-(4-phenoxy-phenylamino)-quinoline-3-ca...)Show SMILES COc1ccc2ncc(C#N)c(Nc3ccc(Oc4ccccc4)cc3)c2c1 Show InChI InChI=1S/C23H17N3O2/c1-27-20-11-12-22-21(13-20)23(16(14-24)15-25-22)26-17-7-9-19(10-8-17)28-18-5-3-2-4-6-18/h2-13,15H,1H3,(H,25,26) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research
Curated by ChEMBL
| Assay Description Inhibition of ERK-phosphorylation by Raf-MEK-ERK in coupled ELISA |
Bioorg Med Chem Lett 10: 2825-8 (2000)
BindingDB Entry DOI: 10.7270/Q22N51J8 |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50095235
(6-Methoxy-7-(2-morpholin-4-yl-ethoxy)-4-(4-phenoxy...)Show SMILES COc1cc2c(Nc3ccc(Oc4ccccc4)cc3)c(cnc2cc1OCCN1CCOCC1)C#N Show InChI InChI=1S/C29H28N4O4/c1-34-27-17-25-26(18-28(27)36-16-13-33-11-14-35-15-12-33)31-20-21(19-30)29(25)32-22-7-9-24(10-8-22)37-23-5-3-2-4-6-23/h2-10,17-18,20H,11-16H2,1H3,(H,31,32) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research
Curated by ChEMBL
| Assay Description Inhibition of ERK-phosphorylation by MEK-ERK in direct ELISA |
Bioorg Med Chem Lett 10: 2825-8 (2000)
BindingDB Entry DOI: 10.7270/Q22N51J8 |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50095229
(7-(3-Morpholin-4-yl-propoxy)-4-(4-phenoxy-phenylam...)Show SMILES N#Cc1cnc2cc(OCCCN3CCOCC3)ccc2c1Nc1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C29H28N4O3/c30-20-22-21-31-28-19-26(35-16-4-13-33-14-17-34-18-15-33)11-12-27(28)29(22)32-23-7-9-25(10-8-23)36-24-5-2-1-3-6-24/h1-3,5-12,19,21H,4,13-18H2,(H,31,32) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research
Curated by ChEMBL
| Assay Description Inhibition of ERK-phosphorylation by Raf-MEK-ERK in coupled ELISA |
Bioorg Med Chem Lett 10: 2825-8 (2000)
BindingDB Entry DOI: 10.7270/Q22N51J8 |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50095226
(6,7-Dimethoxy-4-(4-phenoxy-phenylamino)-quinoline-...)Show SMILES COc1cc2ncc(C#N)c(Nc3ccc(Oc4ccccc4)cc3)c2cc1OC Show InChI InChI=1S/C24H19N3O3/c1-28-22-12-20-21(13-23(22)29-2)26-15-16(14-25)24(20)27-17-8-10-19(11-9-17)30-18-6-4-3-5-7-18/h3-13,15H,1-2H3,(H,26,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research
Curated by ChEMBL
| Assay Description Inhibition of ERK-phosphorylation by MEK-ERK in direct ELISA |
Bioorg Med Chem Lett 10: 2825-8 (2000)
BindingDB Entry DOI: 10.7270/Q22N51J8 |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50095236
(6-Methoxy-4-(4-phenoxy-phenylamino)-quinoline-3-ca...)Show SMILES COc1ccc2ncc(C#N)c(Nc3ccc(Oc4ccccc4)cc3)c2c1 Show InChI InChI=1S/C23H17N3O2/c1-27-20-11-12-22-21(13-20)23(16(14-24)15-25-22)26-17-7-9-19(10-8-17)28-18-5-3-2-4-6-18/h2-13,15H,1H3,(H,25,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research
Curated by ChEMBL
| Assay Description Inhibition of ERK-phosphorylation by MEK-ERK in direct ELISA |
Bioorg Med Chem Lett 10: 2825-8 (2000)
BindingDB Entry DOI: 10.7270/Q22N51J8 |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50095230
(5,7-Dimethoxy-4-(4-phenoxy-phenylamino)-quinoline-...)Show SMILES COc1cc(OC)c2c(Nc3ccc(Oc4ccccc4)cc3)c(cnc2c1)C#N Show InChI InChI=1S/C24H19N3O3/c1-28-20-12-21-23(22(13-20)29-2)24(16(14-25)15-26-21)27-17-8-10-19(11-9-17)30-18-6-4-3-5-7-18/h3-13,15H,1-2H3,(H,26,27) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research
Curated by ChEMBL
| Assay Description Inhibition of ERK-phosphorylation by Raf-MEK-ERK in coupled ELISA |
Bioorg Med Chem Lett 10: 2825-8 (2000)
BindingDB Entry DOI: 10.7270/Q22N51J8 |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50095229
(7-(3-Morpholin-4-yl-propoxy)-4-(4-phenoxy-phenylam...)Show SMILES N#Cc1cnc2cc(OCCCN3CCOCC3)ccc2c1Nc1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C29H28N4O3/c30-20-22-21-31-28-19-26(35-16-4-13-33-14-17-34-18-15-33)11-12-27(28)29(22)32-23-7-9-25(10-8-23)36-24-5-2-1-3-6-24/h1-3,5-12,19,21H,4,13-18H2,(H,31,32) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 68 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research
Curated by ChEMBL
| Assay Description Inhibition of ERK-phosphorylation by MEK-ERK in direct ELISA |
Bioorg Med Chem Lett 10: 2825-8 (2000)
BindingDB Entry DOI: 10.7270/Q22N51J8 |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50095234
(7-Methoxy-4-(4-phenoxy-phenylamino)-quinoline-3-ca...)Show SMILES COc1ccc2c(Nc3ccc(Oc4ccccc4)cc3)c(cnc2c1)C#N Show InChI InChI=1S/C23H17N3O2/c1-27-20-11-12-21-22(13-20)25-15-16(14-24)23(21)26-17-7-9-19(10-8-17)28-18-5-3-2-4-6-18/h2-13,15H,1H3,(H,25,26) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research
Curated by ChEMBL
| Assay Description Inhibition of ERK-phosphorylation by Raf-MEK-ERK in coupled ELISA |
Bioorg Med Chem Lett 10: 2825-8 (2000)
BindingDB Entry DOI: 10.7270/Q22N51J8 |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50095239
(6,7-Dimethoxy-4-(3-phenoxy-phenylamino)-quinoline-...)Show SMILES COc1cc2ncc(C#N)c(Nc3cccc(Oc4ccccc4)c3)c2cc1OC Show InChI InChI=1S/C24H19N3O3/c1-28-22-12-20-21(13-23(22)29-2)26-15-16(14-25)24(20)27-17-7-6-10-19(11-17)30-18-8-4-3-5-9-18/h3-13,15H,1-2H3,(H,26,27) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 95 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research
Curated by ChEMBL
| Assay Description Inhibition of ERK-phosphorylation by Raf-MEK-ERK in coupled ELISA |
Bioorg Med Chem Lett 10: 2825-8 (2000)
BindingDB Entry DOI: 10.7270/Q22N51J8 |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50095231
(5-Methoxy-4-(4-phenoxy-phenylamino)-quinoline-3-ca...)Show SMILES COc1cccc2ncc(C#N)c(Nc3ccc(Oc4ccccc4)cc3)c12 Show InChI InChI=1S/C23H17N3O2/c1-27-21-9-5-8-20-22(21)23(16(14-24)15-25-20)26-17-10-12-19(13-11-17)28-18-6-3-2-4-7-18/h2-13,15H,1H3,(H,25,26) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 98 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research
Curated by ChEMBL
| Assay Description Inhibition of ERK-phosphorylation by Raf-MEK-ERK in coupled ELISA |
Bioorg Med Chem Lett 10: 2825-8 (2000)
BindingDB Entry DOI: 10.7270/Q22N51J8 |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50095239
(6,7-Dimethoxy-4-(3-phenoxy-phenylamino)-quinoline-...)Show SMILES COc1cc2ncc(C#N)c(Nc3cccc(Oc4ccccc4)c3)c2cc1OC Show InChI InChI=1S/C24H19N3O3/c1-28-22-12-20-21(13-23(22)29-2)26-15-16(14-25)24(20)27-17-7-6-10-19(11-17)30-18-8-4-3-5-9-18/h3-13,15H,1-2H3,(H,26,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research
Curated by ChEMBL
| Assay Description Inhibition of ERK-phosphorylation by MEK-ERK in direct ELISA |
Bioorg Med Chem Lett 10: 2825-8 (2000)
BindingDB Entry DOI: 10.7270/Q22N51J8 |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50095234
(7-Methoxy-4-(4-phenoxy-phenylamino)-quinoline-3-ca...)Show SMILES COc1ccc2c(Nc3ccc(Oc4ccccc4)cc3)c(cnc2c1)C#N Show InChI InChI=1S/C23H17N3O2/c1-27-20-11-12-21-22(13-20)25-15-16(14-24)23(21)26-17-7-9-19(10-8-17)28-18-5-3-2-4-6-18/h2-13,15H,1H3,(H,25,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 125 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research
Curated by ChEMBL
| Assay Description Inhibition of ERK-phosphorylation by MEK-ERK in direct ELISA |
Bioorg Med Chem Lett 10: 2825-8 (2000)
BindingDB Entry DOI: 10.7270/Q22N51J8 |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50095233
(4-(4-Phenoxy-phenylamino)-quinoline-3-carbonitrile...)Show InChI InChI=1S/C22H15N3O/c23-14-16-15-24-21-9-5-4-8-20(21)22(16)25-17-10-12-19(13-11-17)26-18-6-2-1-3-7-18/h1-13,15H,(H,24,25) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 125 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research
Curated by ChEMBL
| Assay Description Inhibition of ERK-phosphorylation by Raf-MEK-ERK in coupled ELISA |
Bioorg Med Chem Lett 10: 2825-8 (2000)
BindingDB Entry DOI: 10.7270/Q22N51J8 |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50095230
(5,7-Dimethoxy-4-(4-phenoxy-phenylamino)-quinoline-...)Show SMILES COc1cc(OC)c2c(Nc3ccc(Oc4ccccc4)cc3)c(cnc2c1)C#N Show InChI InChI=1S/C24H19N3O3/c1-28-20-12-21-23(22(13-20)29-2)24(16(14-25)15-26-21)27-17-8-10-19(11-9-17)30-18-6-4-3-5-7-18/h3-13,15H,1-2H3,(H,26,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 185 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research
Curated by ChEMBL
| Assay Description Inhibition of ERK-phosphorylation by MEK-ERK in direct ELISA |
Bioorg Med Chem Lett 10: 2825-8 (2000)
BindingDB Entry DOI: 10.7270/Q22N51J8 |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50095231
(5-Methoxy-4-(4-phenoxy-phenylamino)-quinoline-3-ca...)Show SMILES COc1cccc2ncc(C#N)c(Nc3ccc(Oc4ccccc4)cc3)c12 Show InChI InChI=1S/C23H17N3O2/c1-27-21-9-5-8-20-22(21)23(16(14-24)15-25-20)26-17-10-12-19(13-11-17)28-18-6-3-2-4-7-18/h2-13,15H,1H3,(H,25,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 450 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research
Curated by ChEMBL
| Assay Description Inhibition of ERK-phosphorylation by MEK-ERK in direct ELISA |
Bioorg Med Chem Lett 10: 2825-8 (2000)
BindingDB Entry DOI: 10.7270/Q22N51J8 |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50095233
(4-(4-Phenoxy-phenylamino)-quinoline-3-carbonitrile...)Show InChI InChI=1S/C22H15N3O/c23-14-16-15-24-21-9-5-4-8-20(21)22(16)25-17-10-12-19(13-11-17)26-18-6-2-1-3-7-18/h1-13,15H,(H,24,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 680 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research
Curated by ChEMBL
| Assay Description Inhibition of ERK-phosphorylation by MEK-ERK in direct ELISA |
Bioorg Med Chem Lett 10: 2825-8 (2000)
BindingDB Entry DOI: 10.7270/Q22N51J8 |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50095237
(5,8-Dimethoxy-4-(4-phenoxy-phenylamino)-quinoline-...)Show SMILES COc1ccc(OC)c2c(Nc3ccc(Oc4ccccc4)cc3)c(cnc12)C#N Show InChI InChI=1S/C24H19N3O3/c1-28-20-12-13-21(29-2)24-22(20)23(16(14-25)15-26-24)27-17-8-10-19(11-9-17)30-18-6-4-3-5-7-18/h3-13,15H,1-2H3,(H,26,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research
Curated by ChEMBL
| Assay Description Inhibition of ERK-phosphorylation by MEK-ERK in direct ELISA |
Bioorg Med Chem Lett 10: 2825-8 (2000)
BindingDB Entry DOI: 10.7270/Q22N51J8 |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50095238
(6,7-Dimethoxy-4-(2-phenoxy-phenylamino)-quinoline-...)Show SMILES COc1cc2ncc(C#N)c(Nc3ccccc3Oc3ccccc3)c2cc1OC Show InChI InChI=1S/C24H19N3O3/c1-28-22-12-18-20(13-23(22)29-2)26-15-16(14-25)24(18)27-19-10-6-7-11-21(19)30-17-8-4-3-5-9-17/h3-13,15H,1-2H3,(H,26,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research
Curated by ChEMBL
| Assay Description Inhibition of ERK-phosphorylation by MEK-ERK in direct ELISA |
Bioorg Med Chem Lett 10: 2825-8 (2000)
BindingDB Entry DOI: 10.7270/Q22N51J8 |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50095228
(8-Methoxy-4-(4-phenoxy-phenylamino)-quinoline-3-ca...)Show SMILES COc1cccc2c(Nc3ccc(Oc4ccccc4)cc3)c(cnc12)C#N Show InChI InChI=1S/C23H17N3O2/c1-27-21-9-5-8-20-22(16(14-24)15-25-23(20)21)26-17-10-12-19(13-11-17)28-18-6-3-2-4-7-18/h2-13,15H,1H3,(H,25,26) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research
Curated by ChEMBL
| Assay Description Inhibition of ERK-phosphorylation by Raf-MEK-ERK in coupled ELISA |
Bioorg Med Chem Lett 10: 2825-8 (2000)
BindingDB Entry DOI: 10.7270/Q22N51J8 |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50095238
(6,7-Dimethoxy-4-(2-phenoxy-phenylamino)-quinoline-...)Show SMILES COc1cc2ncc(C#N)c(Nc3ccccc3Oc3ccccc3)c2cc1OC Show InChI InChI=1S/C24H19N3O3/c1-28-22-12-18-20(13-23(22)29-2)26-15-16(14-25)24(18)27-19-10-6-7-11-21(19)30-17-8-4-3-5-9-17/h3-13,15H,1-2H3,(H,26,27) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research
Curated by ChEMBL
| Assay Description Inhibition of ERK-phosphorylation by Raf-MEK-ERK in coupled ELISA |
Bioorg Med Chem Lett 10: 2825-8 (2000)
BindingDB Entry DOI: 10.7270/Q22N51J8 |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50095240
(6,7,8-Trimethoxy-4-(4-phenoxy-phenylamino)-quinoli...)Show SMILES COc1cc2c(Nc3ccc(Oc4ccccc4)cc3)c(cnc2c(OC)c1OC)C#N Show InChI InChI=1S/C25H21N3O4/c1-29-21-13-20-22(16(14-26)15-27-23(20)25(31-3)24(21)30-2)28-17-9-11-19(12-10-17)32-18-7-5-4-6-8-18/h4-13,15H,1-3H3,(H,27,28) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research
Curated by ChEMBL
| Assay Description Inhibition of ERK-phosphorylation by Raf-MEK-ERK in coupled ELISA |
Bioorg Med Chem Lett 10: 2825-8 (2000)
BindingDB Entry DOI: 10.7270/Q22N51J8 |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50095240
(6,7,8-Trimethoxy-4-(4-phenoxy-phenylamino)-quinoli...)Show SMILES COc1cc2c(Nc3ccc(Oc4ccccc4)cc3)c(cnc2c(OC)c1OC)C#N Show InChI InChI=1S/C25H21N3O4/c1-29-21-13-20-22(16(14-26)15-27-23(20)25(31-3)24(21)30-2)28-17-9-11-19(12-10-17)32-18-7-5-4-6-8-18/h4-13,15H,1-3H3,(H,27,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research
Curated by ChEMBL
| Assay Description Inhibition of ERK-phosphorylation by MEK-ERK in direct ELISA |
Bioorg Med Chem Lett 10: 2825-8 (2000)
BindingDB Entry DOI: 10.7270/Q22N51J8 |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50095237
(5,8-Dimethoxy-4-(4-phenoxy-phenylamino)-quinoline-...)Show SMILES COc1ccc(OC)c2c(Nc3ccc(Oc4ccccc4)cc3)c(cnc12)C#N Show InChI InChI=1S/C24H19N3O3/c1-28-20-12-13-21(29-2)24-22(20)23(16(14-25)15-26-24)27-17-8-10-19(11-9-17)30-18-6-4-3-5-7-18/h3-13,15H,1-2H3,(H,26,27) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research
Curated by ChEMBL
| Assay Description Inhibition of ERK-phosphorylation by Raf-MEK-ERK in coupled ELISA |
Bioorg Med Chem Lett 10: 2825-8 (2000)
BindingDB Entry DOI: 10.7270/Q22N51J8 |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50095228
(8-Methoxy-4-(4-phenoxy-phenylamino)-quinoline-3-ca...)Show SMILES COc1cccc2c(Nc3ccc(Oc4ccccc4)cc3)c(cnc12)C#N Show InChI InChI=1S/C23H17N3O2/c1-27-21-9-5-8-20-22(16(14-24)15-25-23(20)21)26-17-10-12-19(13-11-17)28-18-6-3-2-4-7-18/h2-13,15H,1H3,(H,25,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research
Curated by ChEMBL
| Assay Description Inhibition of ERK-phosphorylation by MEK-ERK in direct ELISA |
Bioorg Med Chem Lett 10: 2825-8 (2000)
BindingDB Entry DOI: 10.7270/Q22N51J8 |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50095227
((6,7-Dimethoxy-quinazolin-4-yl)-(4-phenoxy-phenyl)...)Show InChI InChI=1S/C22H19N3O3/c1-26-20-12-18-19(13-21(20)27-2)23-14-24-22(18)25-15-8-10-17(11-9-15)28-16-6-4-3-5-7-16/h3-14H,1-2H3,(H,23,24,25) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research
Curated by ChEMBL
| Assay Description Inhibition of ERK phosphorylation in coupled Raf-MEK-ERK ELISA (Weakly active) |
Bioorg Med Chem Lett 10: 2825-8 (2000)
BindingDB Entry DOI: 10.7270/Q22N51J8 |
More data for this Ligand-Target Pair | |