Found 10 hits Enz. Inhib. hit(s) with all data for entry = 50032838 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
DNA polymerase beta
(Homo sapiens (Human)) | BDBM50335554
(({[({[2-(2-amino-6-oxo-6,9-dihydro-3H-purin-9-yl)e...)Show SMILES Nc1nc2n(CCOCP(O)(=O)OP(O)(=O)OP(O)(O)=O)cnc2c(=O)[nH]1 Show InChI InChI=1S/C8H14N5O11P3/c9-8-11-6-5(7(14)12-8)10-3-13(6)1-2-22-4-25(15,16)23-27(20,21)24-26(17,18)19/h3H,1-2,4H2,(H,15,16)(H,20,21)(H2,17,18,19)(H3,9,11,12,14) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
USA.
Curated by ChEMBL
| Assay Description
Inhibition of human DNA polymerase beta by microplate reader analysis |
Antimicrob Agents Chemother 53: 2777-84 (2009)
Article DOI: 10.1128/AAC.00103-09
BindingDB Entry DOI: 10.7270/Q2M32W2N |
More data for this
Ligand-Target Pair | |
DNA polymerase alpha catalytic subunit
(Homo sapiens (Human)) | BDBM50335554
(({[({[2-(2-amino-6-oxo-6,9-dihydro-3H-purin-9-yl)e...)Show SMILES Nc1nc2n(CCOCP(O)(=O)OP(O)(=O)OP(O)(O)=O)cnc2c(=O)[nH]1 Show InChI InChI=1S/C8H14N5O11P3/c9-8-11-6-5(7(14)12-8)10-3-13(6)1-2-22-4-25(15,16)23-27(20,21)24-26(17,18)19/h3H,1-2,4H2,(H,15,16)(H,20,21)(H2,17,18,19)(H3,9,11,12,14) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
USA.
Curated by ChEMBL
| Assay Description
Inhibition of human DNA polymerase alpha by microplate reader analysis |
Antimicrob Agents Chemother 53: 2777-84 (2009)
Article DOI: 10.1128/AAC.00103-09
BindingDB Entry DOI: 10.7270/Q2M32W2N |
More data for this
Ligand-Target Pair | |
DNA polymerase beta
(Homo sapiens (Human)) | BDBM50335553
(CHEMBL1652466 | [({[2-(2-amino-6-oxo-6,9-dihydro-3...)Show SMILES Nc1nc2n(CCOCP(O)(=O)OP(O)(O)=O)cnc2c(=O)[nH]1 Show InChI InChI=1S/C8H13N5O8P2/c9-8-11-6-5(7(14)12-8)10-3-13(6)1-2-20-4-22(15,16)21-23(17,18)19/h3H,1-2,4H2,(H,15,16)(H2,17,18,19)(H3,9,11,12,14) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.35E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
USA.
Curated by ChEMBL
| Assay Description
Inhibition of human DNA polymerase beta by microplate reader analysis |
Antimicrob Agents Chemother 53: 2777-84 (2009)
Article DOI: 10.1128/AAC.00103-09
BindingDB Entry DOI: 10.7270/Q2M32W2N |
More data for this
Ligand-Target Pair | |
DNA polymerase beta
(Homo sapiens (Human)) | BDBM50335556
(CHEMBL1652469 | [({[({2-[2-amino-6-(cyclopropylami...)Show SMILES Nc1nc(NC2CC2)c2ncn(CCOCP(O)(=O)OP(O)(=O)OP(O)(O)=O)c2n1 Show InChI InChI=1S/C11H19N6O10P3/c12-11-15-9(14-7-1-2-7)8-10(16-11)17(5-13-8)3-4-25-6-28(18,19)26-30(23,24)27-29(20,21)22/h5,7H,1-4,6H2,(H,18,19)(H,23,24)(H2,20,21,22)(H3,12,14,15,16) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
USA.
Curated by ChEMBL
| Assay Description
Inhibition of human DNA polymerase beta by microplate reader analysis |
Antimicrob Agents Chemother 53: 2777-84 (2009)
Article DOI: 10.1128/AAC.00103-09
BindingDB Entry DOI: 10.7270/Q2M32W2N |
More data for this
Ligand-Target Pair | |
DNA polymerase beta
(Homo sapiens (Human)) | BDBM50335555
(CHEMBL1652468 | {[({2-[2-amino-6-(cyclopropylamino...)Show SMILES Nc1nc(NC2CC2)c2ncn(CCOCP(O)(=O)OP(O)(O)=O)c2n1 Show InChI InChI=1S/C11H18N6O7P2/c12-11-15-9(14-7-1-2-7)8-10(16-11)17(5-13-8)3-4-23-6-25(18,19)24-26(20,21)22/h5,7H,1-4,6H2,(H,18,19)(H2,20,21,22)(H3,12,14,15,16) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
USA.
Curated by ChEMBL
| Assay Description
Inhibition of human DNA polymerase beta by microplate reader analysis |
Antimicrob Agents Chemother 53: 2777-84 (2009)
Article DOI: 10.1128/AAC.00103-09
BindingDB Entry DOI: 10.7270/Q2M32W2N |
More data for this
Ligand-Target Pair | |
DNA polymerase subunit gamma-1
(Homo sapiens (Human)) | BDBM50335554
(({[({[2-(2-amino-6-oxo-6,9-dihydro-3H-purin-9-yl)e...)Show SMILES Nc1nc2n(CCOCP(O)(=O)OP(O)(=O)OP(O)(O)=O)cnc2c(=O)[nH]1 Show InChI InChI=1S/C8H14N5O11P3/c9-8-11-6-5(7(14)12-8)10-3-13(6)1-2-22-4-25(15,16)23-27(20,21)24-26(17,18)19/h3H,1-2,4H2,(H,15,16)(H,20,21)(H2,17,18,19)(H3,9,11,12,14) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.94E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
USA.
Curated by ChEMBL
| Assay Description
Inhibition of human DNA polymerase gamma by microplate reader analysis |
Antimicrob Agents Chemother 53: 2777-84 (2009)
Article DOI: 10.1128/AAC.00103-09
BindingDB Entry DOI: 10.7270/Q2M32W2N |
More data for this
Ligand-Target Pair | |
DNA polymerase alpha catalytic subunit
(Homo sapiens (Human)) | BDBM50335556
(CHEMBL1652469 | [({[({2-[2-amino-6-(cyclopropylami...)Show SMILES Nc1nc(NC2CC2)c2ncn(CCOCP(O)(=O)OP(O)(=O)OP(O)(O)=O)c2n1 Show InChI InChI=1S/C11H19N6O10P3/c12-11-15-9(14-7-1-2-7)8-10(16-11)17(5-13-8)3-4-25-6-28(18,19)26-30(23,24)27-29(20,21)22/h5,7H,1-4,6H2,(H,18,19)(H,23,24)(H2,20,21,22)(H3,12,14,15,16) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
USA.
Curated by ChEMBL
| Assay Description
Inhibition of human DNA polymerase alpha by microplate reader analysis |
Antimicrob Agents Chemother 53: 2777-84 (2009)
Article DOI: 10.1128/AAC.00103-09
BindingDB Entry DOI: 10.7270/Q2M32W2N |
More data for this
Ligand-Target Pair | |
DNA polymerase alpha catalytic subunit
(Homo sapiens (Human)) | BDBM50335553
(CHEMBL1652466 | [({[2-(2-amino-6-oxo-6,9-dihydro-3...)Show SMILES Nc1nc2n(CCOCP(O)(=O)OP(O)(O)=O)cnc2c(=O)[nH]1 Show InChI InChI=1S/C8H13N5O8P2/c9-8-11-6-5(7(14)12-8)10-3-13(6)1-2-20-4-22(15,16)21-23(17,18)19/h3H,1-2,4H2,(H,15,16)(H2,17,18,19)(H3,9,11,12,14) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
USA.
Curated by ChEMBL
| Assay Description
Inhibition of human DNA polymerase alpha by microplate reader analysis |
Antimicrob Agents Chemother 53: 2777-84 (2009)
Article DOI: 10.1128/AAC.00103-09
BindingDB Entry DOI: 10.7270/Q2M32W2N |
More data for this
Ligand-Target Pair | |
DNA polymerase alpha catalytic subunit
(Homo sapiens (Human)) | BDBM50335555
(CHEMBL1652468 | {[({2-[2-amino-6-(cyclopropylamino...)Show SMILES Nc1nc(NC2CC2)c2ncn(CCOCP(O)(=O)OP(O)(O)=O)c2n1 Show InChI InChI=1S/C11H18N6O7P2/c12-11-15-9(14-7-1-2-7)8-10(16-11)17(5-13-8)3-4-23-6-25(18,19)24-26(20,21)22/h5,7H,1-4,6H2,(H,18,19)(H2,20,21,22)(H3,12,14,15,16) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
USA.
Curated by ChEMBL
| Assay Description
Inhibition of human DNA polymerase alpha by microplate reader analysis |
Antimicrob Agents Chemother 53: 2777-84 (2009)
Article DOI: 10.1128/AAC.00103-09
BindingDB Entry DOI: 10.7270/Q2M32W2N |
More data for this
Ligand-Target Pair | |
DNA polymerase subunit gamma-1
(Homo sapiens (Human)) | BDBM50335556
(CHEMBL1652469 | [({[({2-[2-amino-6-(cyclopropylami...)Show SMILES Nc1nc(NC2CC2)c2ncn(CCOCP(O)(=O)OP(O)(=O)OP(O)(O)=O)c2n1 Show InChI InChI=1S/C11H19N6O10P3/c12-11-15-9(14-7-1-2-7)8-10(16-11)17(5-13-8)3-4-25-6-28(18,19)26-30(23,24)27-29(20,21)22/h5,7H,1-4,6H2,(H,18,19)(H,23,24)(H2,20,21,22)(H3,12,14,15,16) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.50E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
USA.
Curated by ChEMBL
| Assay Description
Inhibition of human DNA polymerase gamma by microplate reader analysis |
Antimicrob Agents Chemother 53: 2777-84 (2009)
Article DOI: 10.1128/AAC.00103-09
BindingDB Entry DOI: 10.7270/Q2M32W2N |
More data for this
Ligand-Target Pair | |
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