Found 46 hits Enz. Inhib. hit(s) with all data for entry = 50033909 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50353707
(CHEMBL1830791)Show SMILES CC1(C)CCc2c(Nc3c(Cl)cncc3Cl)nc3oc4c(NCc5cccnc5)ncnc4c3c2C1 Show InChI InChI=1S/C26H23Cl2N7O/c1-26(2)6-5-15-16(8-26)19-21-22(24(33-13-32-21)31-10-14-4-3-7-29-9-14)36-25(19)35-23(15)34-20-17(27)11-30-12-18(20)28/h3-4,7,9,11-13H,5-6,8,10H2,1-2H3,(H,30,34,35)(H,31,32,33) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.0200 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4B1 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50353703
(CHEMBL1830646)Show SMILES CC(C)Nc1nc2oc3c(NCCCN4CCCC4=O)ncnc3c2c2CC(C)(C)CCc12 Show InChI InChI=1S/C25H34N6O2/c1-15(2)29-22-16-8-9-25(3,4)13-17(16)19-20-21(33-24(19)30-22)23(28-14-27-20)26-10-6-12-31-11-5-7-18(31)32/h14-15H,5-13H2,1-4H3,(H,29,30)(H,26,27,28) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4B1 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50353703
(CHEMBL1830646)Show SMILES CC(C)Nc1nc2oc3c(NCCCN4CCCC4=O)ncnc3c2c2CC(C)(C)CCc12 Show InChI InChI=1S/C25H34N6O2/c1-15(2)29-22-16-8-9-25(3,4)13-17(16)19-20-21(33-24(19)30-22)23(28-14-27-20)26-10-6-12-31-11-5-7-18(31)32/h14-15H,5-13H2,1-4H3,(H,29,30)(H,26,27,28) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4D3 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50353706
(CHEMBL1828652)Show SMILES CC(C)Nc1nc2oc3c(NCc4cccnc4)ncnc3c2c2CC(C)(C)CCc12 Show InChI InChI=1S/C24H28N6O/c1-14(2)29-21-16-7-8-24(3,4)10-17(16)18-19-20(31-23(18)30-21)22(28-13-27-19)26-12-15-6-5-9-25-11-15/h5-6,9,11,13-14H,7-8,10,12H2,1-4H3,(H,29,30)(H,26,27,28) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4B1 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50353700
(CHEMBL1830643)Show SMILES CC(C)Nc1nc2oc3c(NCCN4CCOCC4)ncnc3c2c2CC(C)(C)CCc12 Show InChI InChI=1S/C24H34N6O2/c1-15(2)28-21-16-5-6-24(3,4)13-17(16)18-19-20(32-23(18)29-21)22(27-14-26-19)25-7-8-30-9-11-31-12-10-30/h14-15H,5-13H2,1-4H3,(H,28,29)(H,25,26,27) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4B1 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM14774
(3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl...)Show SMILES FC(F)Oc1ccc(cc1OCC1CC1)C(=O)Nc1c(Cl)cncc1Cl Show InChI InChI=1S/C17H14Cl2F2N2O3/c18-11-6-22-7-12(19)15(11)23-16(24)10-3-4-13(26-17(20)21)14(5-10)25-8-9-1-2-9/h3-7,9,17H,1-2,8H2,(H,22,23,24) | PDB
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| DrugBank
PDB
Article
PubMed
| n/a | n/a | 0.270 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4D3 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
(Homo sapiens (Human)) | BDBM50353703
(CHEMBL1830646)Show SMILES CC(C)Nc1nc2oc3c(NCCCN4CCCC4=O)ncnc3c2c2CC(C)(C)CCc12 Show InChI InChI=1S/C25H34N6O2/c1-15(2)29-22-16-8-9-25(3,4)13-17(16)19-20-21(33-24(19)30-22)23(28-14-27-20)26-10-6-12-31-11-5-7-18(31)32/h14-15H,5-13H2,1-4H3,(H,29,30)(H,26,27,28) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4A4 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50353700
(CHEMBL1830643)Show SMILES CC(C)Nc1nc2oc3c(NCCN4CCOCC4)ncnc3c2c2CC(C)(C)CCc12 Show InChI InChI=1S/C24H34N6O2/c1-15(2)28-21-16-5-6-24(3,4)13-17(16)18-19-20(32-23(18)29-21)22(27-14-26-19)25-7-8-30-9-11-31-12-10-30/h14-15H,5-13H2,1-4H3,(H,28,29)(H,25,26,27) | PDB
KEGG
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antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4D3 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
(Homo sapiens (Human)) | BDBM50353700
(CHEMBL1830643)Show SMILES CC(C)Nc1nc2oc3c(NCCN4CCOCC4)ncnc3c2c2CC(C)(C)CCc12 Show InChI InChI=1S/C24H34N6O2/c1-15(2)28-21-16-5-6-24(3,4)13-17(16)18-19-20(32-23(18)29-21)22(27-14-26-19)25-7-8-30-9-11-31-12-10-30/h14-15H,5-13H2,1-4H3,(H,28,29)(H,25,26,27) | PDB
MMDB
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UniProtKB/SwissProt
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antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4A4 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50353706
(CHEMBL1828652)Show SMILES CC(C)Nc1nc2oc3c(NCc4cccnc4)ncnc3c2c2CC(C)(C)CCc12 Show InChI InChI=1S/C24H28N6O/c1-14(2)29-21-16-7-8-24(3,4)10-17(16)18-19-20(31-23(18)30-21)22(28-13-27-19)26-12-15-6-5-9-25-11-15/h5-6,9,11,13-14H,7-8,10,12H2,1-4H3,(H,29,30)(H,26,27,28) | PDB
KEGG
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GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
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PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4D3 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
(Homo sapiens (Human)) | BDBM14774
(3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl...)Show SMILES FC(F)Oc1ccc(cc1OCC1CC1)C(=O)Nc1c(Cl)cncc1Cl Show InChI InChI=1S/C17H14Cl2F2N2O3/c18-11-6-22-7-12(19)15(11)23-16(24)10-3-4-13(26-17(20)21)14(5-10)25-8-9-1-2-9/h3-7,9,17H,1-2,8H2,(H,22,23,24) | PDB
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| DrugBank
Article
PubMed
| n/a | n/a | 0.590 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4A4 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM14774
(3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl...)Show SMILES FC(F)Oc1ccc(cc1OCC1CC1)C(=O)Nc1c(Cl)cncc1Cl Show InChI InChI=1S/C17H14Cl2F2N2O3/c18-11-6-22-7-12(19)15(11)23-16(24)10-3-4-13(26-17(20)21)14(5-10)25-8-9-1-2-9/h3-7,9,17H,1-2,8H2,(H,22,23,24) | PDB
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| PDB
Article
PubMed
| n/a | n/a | 0.690 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4B1 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50353695
(CHEMBL1830638)Show SMILES CC1(C)CCc2c(C1)c1c(nc2N2CCOCC2)oc2c(ncnc12)N(CCO)CCN1CCOCC1 Show InChI InChI=1S/C27H38N6O4/c1-27(2)4-3-19-20(17-27)21-22-23(37-26(21)30-24(19)33-10-15-36-16-11-33)25(29-18-28-22)32(7-12-34)6-5-31-8-13-35-14-9-31/h18,34H,3-17H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4B1 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
(Homo sapiens (Human)) | BDBM50353706
(CHEMBL1828652)Show SMILES CC(C)Nc1nc2oc3c(NCc4cccnc4)ncnc3c2c2CC(C)(C)CCc12 Show InChI InChI=1S/C24H28N6O/c1-14(2)29-21-16-7-8-24(3,4)10-17(16)18-19-20(31-23(18)30-21)22(28-13-27-19)26-12-15-6-5-9-25-11-15/h5-6,9,11,13-14H,7-8,10,12H2,1-4H3,(H,29,30)(H,26,27,28) | PDB
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4A4 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50353705
(CHEMBL1830790)Show SMILES CCNc1nc2oc3c(NCc4cccnc4)ncnc3c2c2CC(C)(C)CCc12 Show InChI InChI=1S/C23H26N6O/c1-4-25-20-15-7-8-23(2,3)10-16(15)17-18-19(30-22(17)29-20)21(28-13-27-18)26-12-14-6-5-9-24-11-14/h5-6,9,11,13H,4,7-8,10,12H2,1-3H3,(H,25,29)(H,26,27,28) | PDB
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UniChem
Similars
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PubMed
| n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4D3 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50353701
(CHEMBL1830644)Show SMILES CCNc1nc2oc3c(NCCCN4CCCC4=O)ncnc3c2c2CC(C)(C)CCc12 Show InChI InChI=1S/C24H32N6O2/c1-4-25-21-15-8-9-24(2,3)13-16(15)18-19-20(32-23(18)29-21)22(28-14-27-19)26-10-6-12-30-11-5-7-17(30)31/h14H,4-13H2,1-3H3,(H,25,29)(H,26,27,28) | PDB
KEGG
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4D3 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50353701
(CHEMBL1830644)Show SMILES CCNc1nc2oc3c(NCCCN4CCCC4=O)ncnc3c2c2CC(C)(C)CCc12 Show InChI InChI=1S/C24H32N6O2/c1-4-25-21-15-8-9-24(2,3)13-16(15)18-19-20(32-23(18)29-21)22(28-14-27-19)26-10-6-12-30-11-5-7-17(30)31/h14H,4-13H2,1-3H3,(H,25,29)(H,26,27,28) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4B1 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50353698
(CHEMBL1830641)Show SMILES CCNc1nc2oc3c(NCCN4CCOCC4)ncnc3c2c2CC(C)(C)CCc12 Show InChI InChI=1S/C23H32N6O2/c1-4-24-20-15-5-6-23(2,3)13-16(15)17-18-19(31-22(17)28-20)21(27-14-26-18)25-7-8-29-9-11-30-12-10-29/h14H,4-13H2,1-3H3,(H,24,28)(H,25,26,27) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4B1 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50353695
(CHEMBL1830638)Show SMILES CC1(C)CCc2c(C1)c1c(nc2N2CCOCC2)oc2c(ncnc12)N(CCO)CCN1CCOCC1 Show InChI InChI=1S/C27H38N6O4/c1-27(2)4-3-19-20(17-27)21-22-23(37-26(21)30-24(19)33-10-15-36-16-11-33)25(29-18-28-22)32(7-12-34)6-5-31-8-13-35-14-9-31/h18,34H,3-17H2,1-2H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4D3 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50353698
(CHEMBL1830641)Show SMILES CCNc1nc2oc3c(NCCN4CCOCC4)ncnc3c2c2CC(C)(C)CCc12 Show InChI InChI=1S/C23H32N6O2/c1-4-24-20-15-5-6-23(2,3)13-16(15)17-18-19(31-22(17)28-20)21(27-14-26-18)25-7-8-29-9-11-30-12-10-29/h14H,4-13H2,1-3H3,(H,24,28)(H,25,26,27) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4D3 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50353705
(CHEMBL1830790)Show SMILES CCNc1nc2oc3c(NCc4cccnc4)ncnc3c2c2CC(C)(C)CCc12 Show InChI InChI=1S/C23H26N6O/c1-4-25-20-15-7-8-23(2,3)10-16(15)17-18-19(30-22(17)29-20)21(28-13-27-18)26-12-14-6-5-9-24-11-14/h5-6,9,11,13H,4,7-8,10,12H2,1-3H3,(H,25,29)(H,26,27,28) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
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UniChem
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| Article
PubMed
| n/a | n/a | 4.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4B1 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
(Homo sapiens (Human)) | BDBM50353695
(CHEMBL1830638)Show SMILES CC1(C)CCc2c(C1)c1c(nc2N2CCOCC2)oc2c(ncnc12)N(CCO)CCN1CCOCC1 Show InChI InChI=1S/C27H38N6O4/c1-27(2)4-3-19-20(17-27)21-22-23(37-26(21)30-24(19)33-10-15-36-16-11-33)25(29-18-28-22)32(7-12-34)6-5-31-8-13-35-14-9-31/h18,34H,3-17H2,1-2H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4A4 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
(Homo sapiens (Human)) | BDBM50353701
(CHEMBL1830644)Show SMILES CCNc1nc2oc3c(NCCCN4CCCC4=O)ncnc3c2c2CC(C)(C)CCc12 Show InChI InChI=1S/C24H32N6O2/c1-4-25-21-15-8-9-24(2,3)13-16(15)18-19-20(32-23(18)29-21)22(28-14-27-19)26-10-6-12-30-11-5-7-17(30)31/h14H,4-13H2,1-3H3,(H,25,29)(H,26,27,28) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4A4 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
(Homo sapiens (Human)) | BDBM50353698
(CHEMBL1830641)Show SMILES CCNc1nc2oc3c(NCCN4CCOCC4)ncnc3c2c2CC(C)(C)CCc12 Show InChI InChI=1S/C23H32N6O2/c1-4-24-20-15-5-6-23(2,3)13-16(15)17-18-19(31-22(17)28-20)21(27-14-26-18)25-7-8-29-9-11-30-12-10-29/h14H,4-13H2,1-3H3,(H,24,28)(H,25,26,27) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4A4 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50353692
(CHEMBL1830635)Show SMILES CC1(C)CCc2c(C1)c1c(nc2N2CCOCC2)oc2c(NCc3cccnc3)ncnc12 Show InChI InChI=1S/C25H28N6O2/c1-25(2)6-5-17-18(12-25)19-20-21(33-24(19)30-23(17)31-8-10-32-11-9-31)22(29-15-28-20)27-14-16-4-3-7-26-13-16/h3-4,7,13,15H,5-6,8-12,14H2,1-2H3,(H,27,28,29) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4B1 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
(Homo sapiens (Human)) | BDBM50353705
(CHEMBL1830790)Show SMILES CCNc1nc2oc3c(NCc4cccnc4)ncnc3c2c2CC(C)(C)CCc12 Show InChI InChI=1S/C23H26N6O/c1-4-25-20-15-7-8-23(2,3)10-16(15)17-18-19(30-22(17)29-20)21(28-13-27-18)26-12-14-6-5-9-24-11-14/h5-6,9,11,13H,4,7-8,10,12H2,1-3H3,(H,25,29)(H,26,27,28) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4A4 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50353693
(CHEMBL1830636)Show SMILES CC1(C)CCc2c(C1)c1c(nc2N2CCOCC2)oc2c(NCCN3CCOCC3)ncnc12 Show InChI InChI=1S/C25H34N6O3/c1-25(2)4-3-17-18(15-25)19-20-21(34-24(19)29-23(17)31-9-13-33-14-10-31)22(28-16-27-20)26-5-6-30-7-11-32-12-8-30/h16H,3-15H2,1-2H3,(H,26,27,28) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4B1 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50353693
(CHEMBL1830636)Show SMILES CC1(C)CCc2c(C1)c1c(nc2N2CCOCC2)oc2c(NCCN3CCOCC3)ncnc12 Show InChI InChI=1S/C25H34N6O3/c1-25(2)4-3-17-18(15-25)19-20-21(34-24(19)29-23(17)31-9-13-33-14-10-31)22(28-16-27-20)26-5-6-30-7-11-32-12-8-30/h16H,3-15H2,1-2H3,(H,26,27,28) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4D3 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50353704
(CHEMBL1830647)Show SMILES CCN(C)c1nc2oc3c(NCc4cccnc4)ncnc3c2c2CC(C)(C)CCc12 Show InChI InChI=1S/C24H28N6O/c1-5-30(4)22-16-8-9-24(2,3)11-17(16)18-19-20(31-23(18)29-22)21(28-14-27-19)26-13-15-7-6-10-25-12-15/h6-7,10,12,14H,5,8-9,11,13H2,1-4H3,(H,26,27,28) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4B1 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50353692
(CHEMBL1830635)Show SMILES CC1(C)CCc2c(C1)c1c(nc2N2CCOCC2)oc2c(NCc3cccnc3)ncnc12 Show InChI InChI=1S/C25H28N6O2/c1-25(2)6-5-17-18(12-25)19-20-21(33-24(19)30-23(17)31-8-10-32-11-9-31)22(29-15-28-20)27-14-16-4-3-7-26-13-16/h3-4,7,13,15H,5-6,8-12,14H2,1-2H3,(H,27,28,29) | PDB
KEGG
UniProtKB/SwissProt
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DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4D3 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50353697
(CHEMBL1830640)Show SMILES CC1(C)CCc2c(NCCO)nc3oc4c(NCc5cccnc5)ncnc4c3c2C1 Show InChI InChI=1S/C23H26N6O2/c1-23(2)6-5-15-16(10-23)17-18-19(31-22(17)29-20(15)25-8-9-30)21(28-13-27-18)26-12-14-4-3-7-24-11-14/h3-4,7,11,13,30H,5-6,8-10,12H2,1-2H3,(H,25,29)(H,26,27,28) | PDB
KEGG
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antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 13.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4D3 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50353699
(CHEMBL1830642)Show SMILES CCN(C)c1nc2oc3c(NCCN4CCOCC4)ncnc3c2c2CC(C)(C)CCc12 Show InChI InChI=1S/C24H34N6O2/c1-5-29(4)22-16-6-7-24(2,3)14-17(16)18-19-20(32-23(18)28-22)21(27-15-26-19)25-8-9-30-10-12-31-13-11-30/h15H,5-14H2,1-4H3,(H,25,26,27) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4D3 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
(Homo sapiens (Human)) | BDBM50353693
(CHEMBL1830636)Show SMILES CC1(C)CCc2c(C1)c1c(nc2N2CCOCC2)oc2c(NCCN3CCOCC3)ncnc12 Show InChI InChI=1S/C25H34N6O3/c1-25(2)4-3-17-18(15-25)19-20-21(34-24(19)29-23(17)31-9-13-33-14-10-31)22(28-16-27-20)26-5-6-30-7-11-32-12-8-30/h16H,3-15H2,1-2H3,(H,26,27,28) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 16.3 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4A4 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50353702
(CHEMBL1830645)Show SMILES CCN(C)c1nc2oc3c(NCCCN4CCCC4=O)ncnc3c2c2CC(C)(C)CCc12 Show InChI InChI=1S/C25H34N6O2/c1-5-30(4)23-16-9-10-25(2,3)14-17(16)19-20-21(33-24(19)29-23)22(28-15-27-20)26-11-7-13-31-12-6-8-18(31)32/h15H,5-14H2,1-4H3,(H,26,27,28) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4D3 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50353699
(CHEMBL1830642)Show SMILES CCN(C)c1nc2oc3c(NCCN4CCOCC4)ncnc3c2c2CC(C)(C)CCc12 Show InChI InChI=1S/C24H34N6O2/c1-5-29(4)22-16-6-7-24(2,3)14-17(16)18-19-20(32-23(18)28-22)21(27-15-26-19)25-8-9-30-10-12-31-13-11-30/h15H,5-14H2,1-4H3,(H,25,26,27) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4B1 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
(Homo sapiens (Human)) | BDBM50353692
(CHEMBL1830635)Show SMILES CC1(C)CCc2c(C1)c1c(nc2N2CCOCC2)oc2c(NCc3cccnc3)ncnc12 Show InChI InChI=1S/C25H28N6O2/c1-25(2)6-5-17-18(12-25)19-20-21(33-24(19)30-23(17)31-8-10-32-11-9-31)22(29-15-28-20)27-14-16-4-3-7-26-13-16/h3-4,7,13,15H,5-6,8-12,14H2,1-2H3,(H,27,28,29) | PDB
MMDB
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UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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| CHEMBL
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PC sid
UniChem
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PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4A4 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
(Homo sapiens (Human)) | BDBM50353704
(CHEMBL1830647)Show SMILES CCN(C)c1nc2oc3c(NCc4cccnc4)ncnc3c2c2CC(C)(C)CCc12 Show InChI InChI=1S/C24H28N6O/c1-5-30(4)22-16-8-9-24(2,3)11-17(16)18-19-20(31-23(18)29-22)21(28-14-27-19)26-13-15-7-6-10-25-12-15/h6-7,10,12,14H,5,8-9,11,13H2,1-4H3,(H,26,27,28) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4A4 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50353697
(CHEMBL1830640)Show SMILES CC1(C)CCc2c(NCCO)nc3oc4c(NCc5cccnc5)ncnc4c3c2C1 Show InChI InChI=1S/C23H26N6O2/c1-23(2)6-5-15-16(10-23)17-18-19(31-22(17)29-20(15)25-8-9-30)21(28-13-27-18)26-12-14-4-3-7-24-11-14/h3-4,7,11,13,30H,5-6,8-10,12H2,1-2H3,(H,25,29)(H,26,27,28) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4B1 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50353702
(CHEMBL1830645)Show SMILES CCN(C)c1nc2oc3c(NCCCN4CCCC4=O)ncnc3c2c2CC(C)(C)CCc12 Show InChI InChI=1S/C25H34N6O2/c1-5-30(4)23-16-9-10-25(2,3)14-17(16)19-20-21(33-24(19)29-23)22(28-15-27-20)26-11-7-13-31-12-6-8-18(31)32/h15H,5-14H2,1-4H3,(H,26,27,28) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4B1 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
(Homo sapiens (Human)) | BDBM50353699
(CHEMBL1830642)Show SMILES CCN(C)c1nc2oc3c(NCCN4CCOCC4)ncnc3c2c2CC(C)(C)CCc12 Show InChI InChI=1S/C24H34N6O2/c1-5-29(4)22-16-6-7-24(2,3)14-17(16)18-19-20(32-23(18)28-22)21(27-15-26-19)25-8-9-30-10-12-31-13-11-30/h15H,5-14H2,1-4H3,(H,25,26,27) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4A4 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
(Homo sapiens (Human)) | BDBM50353697
(CHEMBL1830640)Show SMILES CC1(C)CCc2c(NCCO)nc3oc4c(NCc5cccnc5)ncnc4c3c2C1 Show InChI InChI=1S/C23H26N6O2/c1-23(2)6-5-15-16(10-23)17-18-19(31-22(17)29-20(15)25-8-9-30)21(28-13-27-18)26-12-14-4-3-7-24-11-14/h3-4,7,11,13,30H,5-6,8-10,12H2,1-2H3,(H,25,29)(H,26,27,28) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4A4 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
(Homo sapiens (Human)) | BDBM50353702
(CHEMBL1830645)Show SMILES CCN(C)c1nc2oc3c(NCCCN4CCCC4=O)ncnc3c2c2CC(C)(C)CCc12 Show InChI InChI=1S/C25H34N6O2/c1-5-30(4)23-16-9-10-25(2,3)14-17(16)19-20-21(33-24(19)29-23)22(28-15-27-20)26-11-7-13-31-12-6-8-18(31)32/h15H,5-14H2,1-4H3,(H,26,27,28) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 62 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4A4 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50353696
(CHEMBL1830639)Show SMILES CC1(C)Cc2c(CO1)c(nc1oc3c(ncnc3c21)N(CCO)CCN1CCOCC1)N1CCOCC1 Show InChI InChI=1S/C26H36N6O5/c1-26(2)15-18-19(16-36-26)23(32-8-13-35-14-9-32)29-25-20(18)21-22(37-25)24(28-17-27-21)31(5-10-33)4-3-30-6-11-34-12-7-30/h17,33H,3-16H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 79 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4B1 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50353691
(CHEMBL1830634)Show SMILES CC1(C)Cc2c(CO1)c(nc1oc3c(NCc4cccnc4)ncnc3c21)N1CCOCC1 Show InChI InChI=1S/C24H26N6O3/c1-24(2)10-16-17(13-32-24)22(30-6-8-31-9-7-30)29-23-18(16)19-20(33-23)21(28-14-27-19)26-12-15-4-3-5-25-11-15/h3-5,11,14H,6-10,12-13H2,1-2H3,(H,26,27,28) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 235 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4B1 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50353704
(CHEMBL1830647)Show SMILES CCN(C)c1nc2oc3c(NCc4cccnc4)ncnc3c2c2CC(C)(C)CCc12 Show InChI InChI=1S/C24H28N6O/c1-5-30(4)22-16-8-9-24(2,3)11-17(16)18-19-20(31-23(18)29-22)21(28-14-27-19)26-13-15-7-6-10-25-12-15/h6-7,10,12,14H,5,8-9,11,13H2,1-4H3,(H,26,27,28) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 240 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4D3 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50353694
(CHEMBL1830637)Show SMILES CC1(C)Cc2c(CO1)c(nc1oc3c(NCCN4CCOCC4)ncnc3c21)N1CCOCC1 Show InChI InChI=1S/C24H32N6O4/c1-24(2)13-16-17(14-33-24)22(30-7-11-32-12-8-30)28-23-18(16)19-20(34-23)21(27-15-26-19)25-3-4-29-5-9-31-10-6-29/h15H,3-14H2,1-2H3,(H,25,26,27) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 337 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4B1 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assay |
Eur J Med Chem 46: 4946-56 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.054
BindingDB Entry DOI: 10.7270/Q2VM4CPM |
More data for this
Ligand-Target Pair | |
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