Compile Data Set for Download or QSAR

Found 138 hits Enz. Inhib. hit(s) with all data for entry = 520   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275877 (US10071957, Example 96) Show SMILES Fc1cc(COc2cc(Cl)cc(Cl)c2)c(cc1C(=O)NS(=O)(=O)N1CCC1)C1CC1 Show InChI InChI=1S/C20H19Cl2FN2O4S/c21-14-7-15(22)9-16(8-14)29-11-13-6-19(23)18(10-17(13)12-2-3-12)20(26)24-30(27,28)25-4-1-5-25/h6-10,12H,1-5,11H2,(H,24,26)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275876 (US10071957, Example 95) Show SMILES Fc1cc(COc2cc(Cl)cc(OC(F)(F)F)c2)c(cc1C(=O)NS(=O)(=O)N1CCC1)C1CC1 Show InChI InChI=1S/C21H19ClF4N2O5S/c22-14-7-15(9-16(8-14)33-21(24,25)26)32-11-13-6-19(23)18(10-17(13)12-2-3-12)20(29)27-34(30,31)28-4-1-5-28/h6-10,12H,1-5,11H2,(H,27,29)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275868 (US10071957, Example 87) Show SMILES CC(C)Oc1ncc(Oc2cc(F)c(cc2C2CC2)C(=O)NS(=O)(=O)N2CCC2)cc1Cl Show InChI InChI=1S/C21H23ClFN3O5S/c1-12(2)30-21-17(22)8-14(11-24-21)31-19-10-18(23)16(9-15(19)13-4-5-13)20(27)25-32(28,29)26-6-3-7-26/h8-13H,3-7H2,1-2H3,(H,25,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.10	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275873 (US10071957, Example 92) Show SMILES Fc1cc(Oc2cnc(OCC(F)(F)F)c(Cl)c2)c(C=C)cc1C(=O)NS(=O)(=O)N1CCC1 Show InChI InChI=1S/C19H16ClF4N3O5S/c1-2-11-6-13(17(28)26-33(29,30)27-4-3-5-27)15(21)8-16(11)32-12-7-14(20)18(25-9-12)31-10-19(22,23)24/h2,6-9H,1,3-5,10H2,(H,26,28)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.30	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275872 (US10071957, Example 91) Show SMILES CC(C)Oc1ncc(Oc2cc(F)c(cc2C=C)C(=O)NS(=O)(=O)N2CCC2)cc1Cl Show InChI InChI=1S/C20H21ClFN3O5S/c1-4-13-8-15(19(26)24-31(27,28)25-6-5-7-25)17(22)10-18(13)30-14-9-16(21)20(23-11-14)29-12(2)3/h4,8-12H,1,5-7H2,2-3H3,(H,24,26)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275868 (US10071957, Example 87) Show SMILES CC(C)Oc1ncc(Oc2cc(F)c(cc2C2CC2)C(=O)NS(=O)(=O)N2CCC2)cc1Cl Show InChI InChI=1S/C21H23ClFN3O5S/c1-12(2)30-21-17(22)8-14(11-24-21)31-19-10-18(23)16(9-15(19)13-4-5-13)20(27)25-32(28,29)26-6-3-7-26/h8-13H,3-7H2,1-2H3,(H,25,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM50118513 (CHEMBL3617065 | US10071957, Example 6) Show SMILES CNS(=O)(=O)NC(=O)c1cc(Cl)c(Oc2cnc(OCC(C)C)c(Cl)c2)cc1F Show InChI InChI=1S/C17H18Cl2FN3O5S/c1-9(2)8-27-17-13(19)4-10(7-22-17)28-15-6-14(20)11(5-12(15)18)16(24)23-29(25,26)21-3/h4-7,9,21H,8H2,1-3H3,(H,23,24)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275871 (US10071957, Example 90) Show SMILES CNS(=O)(=O)NC(=O)c1cc(C2CC2)c(Oc2cnc(OC(C)C)c(Cl)c2)cc1F Show InChI InChI=1S/C19H21ClFN3O5S/c1-10(2)28-19-15(20)6-12(9-23-19)29-17-8-16(21)14(7-13(17)11-4-5-11)18(25)24-30(26,27)22-3/h6-11,22H,4-5H2,1-3H3,(H,24,25)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275863 (US10071957, Example 82) Show SMILES CC(C)Oc1ncc(OCc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)N2CCC2)cc1Cl Show InChI InChI=1S/C19H20Cl2FN3O5S/c1-11(2)30-19-16(21)7-13(9-23-19)29-10-12-6-17(22)14(8-15(12)20)18(26)24-31(27,28)25-4-3-5-25/h6-9,11H,3-5,10H2,1-2H3,(H,24,26)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.10	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275872 (US10071957, Example 91) Show SMILES CC(C)Oc1ncc(Oc2cc(F)c(cc2C=C)C(=O)NS(=O)(=O)N2CCC2)cc1Cl Show InChI InChI=1S/C20H21ClFN3O5S/c1-4-13-8-15(19(26)24-31(27,28)25-6-5-7-25)17(22)10-18(13)30-14-9-16(21)20(23-11-14)29-12(2)3/h4,8-12H,1,5-7H2,2-3H3,(H,24,26)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.70	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275865 (US10071957, Example 84) Show SMILES CC(C)Oc1ncc(Oc2ccc(cc2C2CC2)C(=O)NS(=O)(=O)N2CCC2)cc1Cl Show InChI InChI=1S/C21H24ClN3O5S/c1-13(2)29-21-18(22)11-16(12-23-21)30-19-7-6-15(10-17(19)14-4-5-14)20(26)24-31(27,28)25-8-3-9-25/h6-7,10-14H,3-5,8-9H2,1-2H3,(H,24,26)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.40	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM50118513 (CHEMBL3617065 | US10071957, Example 6) Show SMILES CNS(=O)(=O)NC(=O)c1cc(Cl)c(Oc2cnc(OCC(C)C)c(Cl)c2)cc1F Show InChI InChI=1S/C17H18Cl2FN3O5S/c1-9(2)8-27-17-13(19)4-10(7-22-17)28-15-6-14(20)11(5-12(15)18)16(24)23-29(25,26)21-3/h4-7,9,21H,8H2,1-3H3,(H,23,24)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8.5	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275809 (N-((1H-imidazol-4- yl)sulfonyl)-5-chloro- 4-((5-ch...) Show SMILES CC(C)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)c2c[nH]cn2)cc1Cl Show InChI InChI=1S/C19H17Cl2FN4O5S/c1-10(2)8-30-19-14(21)3-11(6-24-19)31-16-5-15(22)12(4-13(16)20)18(27)26-32(28,29)17-7-23-9-25-17/h3-7,9-10H,8H2,1-2H3,(H,23,25)(H,26,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275787 (5-chloro-4-((5-chloro- 6-isobutoxypyridin- 3-yl)ox...) Show SMILES CC(C)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(N)(=O)=O)cc1Cl Show InChI InChI=1S/C16H16Cl2FN3O5S/c1-8(2)7-26-16-12(18)3-9(6-21-16)27-14-5-13(19)10(4-11(14)17)15(23)22-28(20,24)25/h3-6,8H,7H2,1-2H3,(H,22,23)(H2,20,24,25)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275879 (US10071957, Example 98) Show SMILES Fc1cc(COc2ccc(Cl)c(Cl)c2)c(cc1C(=O)NS(=O)(=O)N1CCC1)C1CC1 Show InChI InChI=1S/C20H19Cl2FN2O4S/c21-17-5-4-14(9-18(17)22)29-11-13-8-19(23)16(10-15(13)12-2-3-12)20(26)24-30(27,28)25-6-1-7-25/h4-5,8-10,12H,1-3,6-7,11H2,(H,24,26)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275875 (US10071957, Example 94) Show SMILES Fc1cc(Oc2cnc(OCC(F)(F)F)c(Cl)c2)c(cc1C(=O)NS(=O)(=O)N1CCC1)C1CC1 Show InChI InChI=1S/C20H18ClF4N3O5S/c21-15-6-12(9-26-19(15)32-10-20(23,24)25)33-17-8-16(22)14(7-13(17)11-2-3-11)18(29)27-34(30,31)28-4-1-5-28/h6-9,11H,1-5,10H2,(H,27,29)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275828 (N-(azetidin-1- ylsulfonyl)-5-chloro- 4-((5-chloro-...) Show SMILES CC(C)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)N2CCC2)cc1Cl Show InChI InChI=1S/C19H20Cl2FN3O5S/c1-11(2)10-29-19-15(21)6-12(9-23-19)30-17-8-16(22)13(7-14(17)20)18(26)24-31(27,28)25-4-3-5-25/h6-9,11H,3-5,10H2,1-2H3,(H,24,26)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9.20	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275784 (5-chloro-4-((5-chloro- 6-isobutoxypyridin- 3-yl)ox...) Show SMILES CC(C)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)N(C)C)cc1Cl Show InChI InChI=1S/C18H20Cl2FN3O5S/c1-10(2)9-28-18-14(20)5-11(8-22-18)29-16-7-15(21)12(6-13(16)19)17(25)23-30(26,27)24(3)4/h5-8,10H,9H2,1-4H3,(H,23,25)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275867 (US10071957, Example 86) Show SMILES COc1ncccc1-c1cc(ccc1Oc1cnc(OC(C)C)c(Cl)c1)C(=O)NS(=O)(=O)N1CCC1 Show InChI InChI=1S/C24H25ClN4O6S/c1-15(2)34-24-20(25)13-17(14-27-24)35-21-8-7-16(22(30)28-36(31,32)29-10-5-11-29)12-19(21)18-6-4-9-26-23(18)33-3/h4,6-9,12-15H,5,10-11H2,1-3H3,(H,28,30)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275873 (US10071957, Example 92) Show SMILES Fc1cc(Oc2cnc(OCC(F)(F)F)c(Cl)c2)c(C=C)cc1C(=O)NS(=O)(=O)N1CCC1 Show InChI InChI=1S/C19H16ClF4N3O5S/c1-2-11-6-13(17(28)26-33(29,30)27-4-3-5-27)15(21)8-16(11)32-12-7-14(20)18(25-9-12)31-10-19(22,23)24/h2,6-9H,1,3-5,10H2,(H,26,28)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275861 (US10071957, Example 80) Show SMILES CNS(=O)(=O)NC(=O)c1cc(Cl)c(COc2ccc(Cl)c(Cl)c2)cc1F Show InChI InChI=1S/C15H12Cl3FN2O4S/c1-20-26(23,24)21-15(22)10-6-12(17)8(4-14(10)19)7-25-9-2-3-11(16)13(18)5-9/h2-6,20H,7H2,1H3,(H,21,22)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11.6	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275794 (5-chloro-4-(3-chloro- 4-(trifluoromethoxy) phenoxy...) Show SMILES CNS(=O)(=O)NC(=O)c1cc(Cl)c(Oc2ccc(OC(F)(F)F)c(Cl)c2)cc1F Show InChI InChI=1S/C15H10Cl2F4N2O5S/c1-22-29(25,26)23-14(24)8-5-10(17)13(6-11(8)18)27-7-2-3-12(9(16)4-7)28-15(19,20)21/h2-6,22H,1H3,(H,23,24)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275874 (US10071957, Example 93) Show SMILES Fc1cc(Oc2cnc(OCC(F)(F)F)c(Cl)c2)c(Cl)cc1C(=O)NS(=O)(=O)N1CCC1 Show InChI InChI=1S/C17H13Cl2F4N3O5S/c18-11-5-10(15(27)25-32(28,29)26-2-1-3-26)13(20)6-14(11)31-9-4-12(19)16(24-7-9)30-8-17(21,22)23/h4-7H,1-3,8H2,(H,25,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275792 (N-(azetidin-1- ylsulfonyl)-5-chloro- 4-(4-chloro-3...) Show SMILES Fc1cc(Oc2ccc(Cl)c(c2)C(F)(F)F)c(Cl)cc1C(=O)NS(=O)(=O)N1CCC1 Show InChI InChI=1S/C17H12Cl2F4N2O4S/c18-12-3-2-9(6-11(12)17(21,22)23)29-15-8-14(20)10(7-13(15)19)16(26)24-30(27,28)25-4-1-5-25/h2-3,6-8H,1,4-5H2,(H,24,26)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275860 (US10071957, Example 79) Show SMILES Fc1cc(COc2ccc(OC(F)(F)F)c(Cl)c2)c(Cl)cc1C(=O)NS(=O)(=O)N1CCC1 Show InChI InChI=1S/C18H14Cl2F4N2O5S/c19-13-8-12(17(27)25-32(28,29)26-4-1-5-26)15(21)6-10(13)9-30-11-2-3-16(14(20)7-11)31-18(22,23)24/h2-3,6-8H,1,4-5,9H2,(H,25,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275788 (5-chloro-4-((3,4- dichlorophenoxy) methyl)-N-(N,N-...) Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(COc2ccc(Cl)c(Cl)c2)cc1F Show InChI InChI=1S/C16H14Cl3FN2O4S/c1-22(2)27(24,25)21-16(23)11-7-13(18)9(5-15(11)20)8-26-10-3-4-12(17)14(19)6-10/h3-7H,8H2,1-2H3,(H,21,23)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	19	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275867 (US10071957, Example 86) Show SMILES COc1ncccc1-c1cc(ccc1Oc1cnc(OC(C)C)c(Cl)c1)C(=O)NS(=O)(=O)N1CCC1 Show InChI InChI=1S/C24H25ClN4O6S/c1-15(2)34-24-20(25)13-17(14-27-24)35-21-8-7-16(22(30)28-36(31,32)29-10-5-11-29)12-19(21)18-6-4-9-26-23(18)33-3/h4,6-9,12-15H,5,10-11H2,1-3H3,(H,28,30)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	22	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275791 (5-chloro-4-(4-chloro- 3-(trifluoromethyl) phenoxy)...) Show SMILES CNS(=O)(=O)NC(=O)c1cc(Cl)c(Oc2ccc(Cl)c(c2)C(F)(F)F)cc1F Show InChI InChI=1S/C15H10Cl2F4N2O4S/c1-22-28(25,26)23-14(24)8-5-11(17)13(6-12(8)18)27-7-2-3-10(16)9(4-7)15(19,20)21/h2-6,22H,1H3,(H,23,24)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	22	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275815 (5-chloro-4-((5-chloro- 6-(2,2,3,3-tetrafluoro- pro...) Show SMILES CNS(=O)(=O)NC(=O)c1cc(Cl)c(Oc2cnc(OCC(F)(F)C(F)F)c(Cl)c2)cc1F Show InChI InChI=1S/C16H12Cl2F5N3O5S/c1-24-32(28,29)26-13(27)8-3-9(17)12(4-11(8)19)31-7-2-10(18)14(25-5-7)30-6-16(22,23)15(20)21/h2-5,15,24H,6H2,1H3,(H,26,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	22.8	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275784 (5-chloro-4-((5-chloro- 6-isobutoxypyridin- 3-yl)ox...) Show SMILES CC(C)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)N(C)C)cc1Cl Show InChI InChI=1S/C18H20Cl2FN3O5S/c1-10(2)9-28-18-14(20)5-11(8-22-18)29-16-7-15(21)12(6-13(16)19)17(25)23-30(26,27)24(3)4/h5-8,10H,9H2,1-4H3,(H,23,25)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	24.8	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275865 (US10071957, Example 84) Show SMILES CC(C)Oc1ncc(Oc2ccc(cc2C2CC2)C(=O)NS(=O)(=O)N2CCC2)cc1Cl Show InChI InChI=1S/C21H24ClN3O5S/c1-13(2)29-21-18(22)11-16(12-23-21)30-19-7-6-15(10-17(19)14-4-5-14)20(26)24-31(27,28)25-8-3-9-25/h6-7,10-14H,3-5,8-9H2,1-2H3,(H,24,26)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	25	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275866 (US10071957, Example 85) Show SMILES Fc1cc(COc2ccc(Cl)c(c2)C(F)(F)F)c(Cl)cc1C(=O)NS(=O)(=O)N1CCC1 Show InChI InChI=1S/C18H14Cl2F4N2O4S/c19-14-3-2-11(7-13(14)18(22,23)24)30-9-10-6-16(21)12(8-15(10)20)17(27)25-31(28,29)26-4-1-5-26/h2-3,6-8H,1,4-5,9H2,(H,25,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	26	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275847 (5-chloro-4-((5-chloro- 6-(2,2,3,3-tetrafluoro- pro...) Show SMILES FC(F)C(F)(F)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)N2CCCC2)cc1Cl Show InChI InChI=1S/C19H16Cl2F5N3O5S/c20-12-6-11(16(30)28-35(31,32)29-3-1-2-4-29)14(22)7-15(12)34-10-5-13(21)17(27-8-10)33-9-19(25,26)18(23)24/h5-8,18H,1-4,9H2,(H,28,30)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	26	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275861 (US10071957, Example 80) Show SMILES CNS(=O)(=O)NC(=O)c1cc(Cl)c(COc2ccc(Cl)c(Cl)c2)cc1F Show InChI InChI=1S/C15H12Cl3FN2O4S/c1-20-26(23,24)21-15(22)10-6-12(17)8(4-14(10)19)7-25-9-2-3-11(16)13(18)5-9/h2-6,20H,7H2,1H3,(H,21,22)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	28	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275797 (5-chloro-4-((5-chloro- 6-isobutoxypyridin- 3-yl)ox...) Show SMILES CC(C)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)N2CCCC2)cc1Cl Show InChI InChI=1S/C20H22Cl2FN3O5S/c1-12(2)11-30-20-16(22)7-13(10-24-20)31-18-9-17(23)14(8-15(18)21)19(27)25-32(28,29)26-5-3-4-6-26/h7-10,12H,3-6,11H2,1-2H3,(H,25,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	30.1	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275813 (5-chloro-4-(5-chloro- 6-(2,2,3,3-tetrafluoro- prop...) Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(Oc2cnc(OCC(F)(F)C(F)F)c(Cl)c2)cc1F Show InChI InChI=1S/C17H14Cl2F5N3O5S/c1-27(2)33(29,30)26-14(28)9-4-10(18)13(5-12(9)20)32-8-3-11(19)15(25-6-8)31-7-17(23,24)16(21)22/h3-6,16H,7H2,1-2H3,(H,26,28)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	34	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275807 (5-chloro-4-((5-chloro- 6-isobutoxypyridin- 3-yl)ox...) Show SMILES CC(C)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)c2cn(C)cn2)cc1Cl Show InChI InChI=1S/C20H19Cl2FN4O5S/c1-11(2)9-31-20-15(22)4-12(7-24-20)32-17-6-16(23)13(5-14(17)21)19(28)26-33(29,30)18-8-27(3)10-25-18/h4-8,10-11H,9H2,1-3H3,(H,26,28)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	34	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275821 (5-chloro-4-(((5-chloro- 6-(2,2,3,3-tetrafluoro- pr...) Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(COc2cnc(OCC(F)(F)C(F)F)c(Cl)c2)cc1F Show InChI InChI=1S/C18H16Cl2F5N3O5S/c1-28(2)34(30,31)27-15(29)11-5-12(19)9(3-14(11)21)7-32-10-4-13(20)16(26-6-10)33-8-18(24,25)17(22)23/h3-6,17H,7-8H2,1-2H3,(H,27,29)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	34.3	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275859 (US10071957, Example 78) Show SMILES CNS(=O)(=O)NC(=O)c1cc(Cl)c(COc2ccc(Cl)c(c2)C(F)(F)F)cc1F Show InChI InChI=1S/C16H12Cl2F4N2O4S/c1-23-29(26,27)24-15(25)10-6-13(18)8(4-14(10)19)7-28-9-2-3-12(17)11(5-9)16(20,21)22/h2-6,23H,7H2,1H3,(H,24,25)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	35	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275795 (5-chloro-4-(3-chloro- 4-(trifluoromethoxy) phenoxy...) Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(Oc2ccc(OC(F)(F)F)c(Cl)c2)cc1F Show InChI InChI=1S/C16H12Cl2F4N2O5S/c1-24(2)30(26,27)23-15(25)9-6-11(18)14(7-12(9)19)28-8-3-4-13(10(17)5-8)29-16(20,21)22/h3-7H,1-2H3,(H,23,25)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	41	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275881 (US10071957, Example 100) Show SMILES CNS(=O)(=O)NC(=O)c1cc(Cl)c(COc2ccc(OC(F)(F)F)c(Cl)c2)cc1F Show InChI InChI=1S/C16H12Cl2F4N2O5S/c1-23-30(26,27)24-15(25)10-6-11(17)8(4-13(10)19)7-28-9-2-3-14(12(18)5-9)29-16(20,21)22/h2-6,23H,7H2,1H3,(H,24,25)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	43	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275864 (US10071957, Example 83) Show SMILES CNS(=O)(=O)NC(=O)c1ccc(Oc2cnc(OC(C)C)c(Cl)c2)c(c1)-c1cccnc1OC Show InChI InChI=1S/C22H23ClN4O6S/c1-13(2)32-22-18(23)11-15(12-26-22)33-19-8-7-14(20(28)27-34(29,30)24-3)10-17(19)16-6-5-9-25-21(16)31-4/h5-13,24H,1-4H3,(H,27,28)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	43	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275863 (US10071957, Example 82) Show SMILES CC(C)Oc1ncc(OCc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)N2CCC2)cc1Cl Show InChI InChI=1S/C19H20Cl2FN3O5S/c1-11(2)30-19-16(21)7-13(9-23-19)29-10-12-6-17(22)14(8-15(12)20)18(26)24-31(27,28)25-4-3-5-25/h6-9,11H,3-5,10H2,1-2H3,(H,24,26)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	43	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275797 (5-chloro-4-((5-chloro- 6-isobutoxypyridin- 3-yl)ox...) Show SMILES CC(C)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)N2CCCC2)cc1Cl Show InChI InChI=1S/C20H22Cl2FN3O5S/c1-12(2)11-30-20-16(22)7-13(10-24-20)31-18-9-17(23)14(8-15(18)21)19(27)25-32(28,29)26-5-3-4-6-26/h7-10,12H,3-6,11H2,1-2H3,(H,25,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	44	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275869 (US10071957, Example 88) Show SMILES CC(C)Oc1ncc(Oc2cc(F)c(cc2C2(F)COC2)C(=O)NS(=O)(=O)N2CCC2)cc1Cl Show InChI InChI=1S/C21H22ClF2N3O6S/c1-12(2)32-20-16(22)6-13(9-25-20)33-18-8-17(23)14(7-15(18)21(24)10-31-11-21)19(28)26-34(29,30)27-4-3-5-27/h6-9,12H,3-5,10-11H2,1-2H3,(H,26,28)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	44	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275813 (5-chloro-4-(5-chloro- 6-(2,2,3,3-tetrafluoro- prop...) Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(Oc2cnc(OCC(F)(F)C(F)F)c(Cl)c2)cc1F Show InChI InChI=1S/C17H14Cl2F5N3O5S/c1-27(2)33(29,30)26-14(28)9-4-10(18)13(5-12(9)20)32-8-3-11(19)15(25-6-8)31-7-17(23,24)16(21)22/h3-6,16H,7H2,1-2H3,(H,26,28)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	47.8	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275880 (US10071957, Example 99) Show SMILES Fc1cc(COc2ccc(Cl)c(Cl)c2)c(Cl)cc1C(=O)NS(=O)(=O)N1CCC1 Show InChI InChI=1S/C17H14Cl3FN2O4S/c18-13-3-2-11(7-15(13)20)27-9-10-6-16(21)12(8-14(10)19)17(24)22-28(25,26)23-4-1-5-23/h2-3,6-8H,1,4-5,9H2,(H,22,24)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	51	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275878 (US10071957, Example 97) Show SMILES COc1ncccc1-c1cc(ccc1Oc1ccc(OC(F)(F)F)c(Cl)c1)C(=O)NS(=O)(=O)N1CCC1 Show InChI InChI=1S/C23H19ClF3N3O6S/c1-34-22-16(4-2-9-28-22)17-12-14(21(31)29-37(32,33)30-10-3-11-30)5-7-19(17)35-15-6-8-20(18(24)13-15)36-23(25,26)27/h2,4-9,12-13H,3,10-11H2,1H3,(H,29,31)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	52	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275770 (5-chloro-4-(4-chloro- 3-(trifluoromethyl) phenoxy)...) Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(Oc2ccc(Cl)c(c2)C(F)(F)F)cc1F Show InChI InChI=1S/C16H12Cl2F4N2O4S/c1-24(2)29(26,27)23-15(25)9-6-12(18)14(7-13(9)19)28-8-3-4-11(17)10(5-8)16(20,21)22/h3-7H,1-2H3,(H,23,25)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	53	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM275811 (5-chloro-4-((5-chloro- 6-isobutoxypyridin- 3-yl)ox...) Show SMILES CC(C)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)c2cccnc2)cc1Cl Show InChI InChI=1S/C21H18Cl2FN3O5S/c1-12(2)11-31-21-17(23)6-13(9-26-21)32-19-8-18(24)15(7-16(19)22)20(28)27-33(29,30)14-4-3-5-25-10-14/h3-10,12H,11H2,1-2H3,(H,27,28)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	57	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...				US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P
					More data for this Ligand-Target Pair

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