Compile Data Set for Download or QSAR

Found 58 hits Enz. Inhib. hit(s) with all data for assayid = 1 entry = 2965   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM26429 ((2E)-3-{4-[({8-carbamoyl-7-[(3,5-dimethoxyphenyl)a...) Show SMILES COc1cc(Nc2nc(NCc3ccc(\C=C\C(O)=O)cc3)n3ccnc3c2C(N)=O)cc(OC)c1 Show InChI InChI=1S/C25H24N6O5/c1-35-18-11-17(12-19(13-18)36-2)29-23-21(22(26)34)24-27-9-10-31(24)25(30-23)28-14-16-5-3-15(4-6-16)7-8-20(32)33/h3-13,29H,14H2,1-2H3,(H2,26,34)(H,28,30)(H,32,33)/b8-7+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	47	n/a	n/a	n/a	n/a	7.6	30
Kissei Pharmaceutical Company					Assay Description A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...				Bioorg Med Chem 17: 284-94 (2009) Article DOI: 10.1016/j.bmc.2008.10.070 BindingDB Entry DOI: 10.7270/Q2FQ9TXB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM26428 (ethyl (2E)-3-{4-[({8-carbamoyl-7-[(3,5-dimethoxyph...) Show SMILES CCOC(=O)\C=C\c1ccc(CNc2nc(Nc3cc(OC)cc(OC)c3)c(C(N)=O)c3nccn23)cc1 Show InChI InChI=1S/C27H28N6O5/c1-4-38-22(34)10-9-17-5-7-18(8-6-17)16-30-27-32-25(23(24(28)35)26-29-11-12-33(26)27)31-19-13-20(36-2)15-21(14-19)37-3/h5-15,31H,4,16H2,1-3H3,(H2,28,35)(H,30,32)/b10-9+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	88	n/a	n/a	n/a	n/a	7.6	30
Kissei Pharmaceutical Company					Assay Description A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...				Bioorg Med Chem 17: 284-94 (2009) Article DOI: 10.1016/j.bmc.2008.10.070 BindingDB Entry DOI: 10.7270/Q2FQ9TXB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM26415 (5-{[(2,4-difluorophenyl)methyl]amino}-7-[(3,5-dime...) Show SMILES COc1cc(Nc2nc(NCc3ccc(F)cc3F)n3ccnc3c2C(N)=O)cc(OC)c1 Show InChI InChI=1S/C22H20F2N6O3/c1-32-15-8-14(9-16(10-15)33-2)28-20-18(19(25)31)21-26-5-6-30(21)22(29-20)27-11-12-3-4-13(23)7-17(12)24/h3-10,28H,11H2,1-2H3,(H2,25,31)(H,27,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	7.6	30
Kissei Pharmaceutical Company					Assay Description A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...				Bioorg Med Chem 17: 284-94 (2009) Article DOI: 10.1016/j.bmc.2008.10.070 BindingDB Entry DOI: 10.7270/Q2FQ9TXB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM26419 (7-[(3,5-dimethoxyphenyl)amino]-5-{[(4-sulfamoylphe...) Show SMILES COc1cc(Nc2nc(NCc3ccc(cc3)S(N)(=O)=O)n3ccnc3c2C(N)=O)cc(OC)c1 Show InChI InChI=1S/C22H23N7O5S/c1-33-15-9-14(10-16(11-15)34-2)27-20-18(19(23)30)21-25-7-8-29(21)22(28-20)26-12-13-3-5-17(6-4-13)35(24,31)32/h3-11,27H,12H2,1-2H3,(H2,23,30)(H,26,28)(H2,24,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	7.6	30
Kissei Pharmaceutical Company					Assay Description A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...				Bioorg Med Chem 17: 284-94 (2009) Article DOI: 10.1016/j.bmc.2008.10.070 BindingDB Entry DOI: 10.7270/Q2FQ9TXB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM26422 (4-[({8-carbamoyl-7-[(3,5-dimethoxyphenyl)amino]imi...) Show SMILES COc1cc(Nc2nc(NCc3ccc(cc3)C(O)=O)n3ccnc3c2C(N)=O)cc(OC)c1 Show InChI InChI=1S/C23H22N6O5/c1-33-16-9-15(10-17(11-16)34-2)27-20-18(19(24)30)21-25-7-8-29(21)23(28-20)26-12-13-3-5-14(6-4-13)22(31)32/h3-11,27H,12H2,1-2H3,(H2,24,30)(H,26,28)(H,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	180	n/a	n/a	n/a	n/a	7.6	30
Kissei Pharmaceutical Company					Assay Description A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...				Bioorg Med Chem 17: 284-94 (2009) Article DOI: 10.1016/j.bmc.2008.10.070 BindingDB Entry DOI: 10.7270/Q2FQ9TXB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM26420 (7-[(3,5-dimethoxyphenyl)amino]-5-{[(4-methanesulfo...) Show SMILES COc1cc(Nc2nc(NCc3ccc(cc3)S(C)(=O)=O)n3ccnc3c2C(N)=O)cc(OC)c1 Show InChI InChI=1S/C23H24N6O5S/c1-33-16-10-15(11-17(12-16)34-2)27-21-19(20(24)30)22-25-8-9-29(22)23(28-21)26-13-14-4-6-18(7-5-14)35(3,31)32/h4-12,27H,13H2,1-3H3,(H2,24,30)(H,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	190	n/a	n/a	n/a	n/a	7.6	30
Kissei Pharmaceutical Company					Assay Description A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...				Bioorg Med Chem 17: 284-94 (2009) Article DOI: 10.1016/j.bmc.2008.10.070 BindingDB Entry DOI: 10.7270/Q2FQ9TXB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM26418 (5-[(1H-1,3-benzodiazol-2-ylmethyl)amino]-7-[(3,5-d...) Show SMILES COc1cc(Nc2nc(NCc3nc4ccccc4[nH]3)n3ccnc3c2C(N)=O)cc(OC)c1 Show InChI InChI=1S/C23H22N8O3/c1-33-14-9-13(10-15(11-14)34-2)27-21-19(20(24)32)22-25-7-8-31(22)23(30-21)26-12-18-28-16-5-3-4-6-17(16)29-18/h3-11,27H,12H2,1-2H3,(H2,24,32)(H,26,30)(H,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	7.6	30
Kissei Pharmaceutical Company					Assay Description A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...				Bioorg Med Chem 17: 284-94 (2009) Article DOI: 10.1016/j.bmc.2008.10.070 BindingDB Entry DOI: 10.7270/Q2FQ9TXB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM26410 (7-[(3,5-dimethoxyphenyl)amino]-5-{[(4-fluorophenyl...) Show SMILES COc1cc(Nc2nc(NCc3ccc(F)cc3)n3ccnc3c2C(N)=O)cc(OC)c1 Show InChI InChI=1S/C22H21FN6O3/c1-31-16-9-15(10-17(11-16)32-2)27-20-18(19(24)30)21-25-7-8-29(21)22(28-20)26-12-13-3-5-14(23)6-4-13/h3-11,27H,12H2,1-2H3,(H2,24,30)(H,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	220	n/a	n/a	n/a	n/a	7.6	30
Kissei Pharmaceutical Company					Assay Description A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...				Bioorg Med Chem 17: 284-94 (2009) Article DOI: 10.1016/j.bmc.2008.10.070 BindingDB Entry DOI: 10.7270/Q2FQ9TXB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM26404 (5-[(2-aminoethyl)amino]-7-[(3,5-dimethoxyphenyl)am...) Show SMILES COc1cc(Nc2nc(NCCN)n3ccnc3c2C(N)=O)cc(OC)c1 Show InChI InChI=1S/C17H21N7O3/c1-26-11-7-10(8-12(9-11)27-2)22-15-13(14(19)25)16-20-5-6-24(16)17(23-15)21-4-3-18/h5-9,22H,3-4,18H2,1-2H3,(H2,19,25)(H,21,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	230	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Company					Assay Description A coupled spectrophotometric assay was used, wherein ADP generated by Syk kinase was converted to ATP by pyruvate kinase (PK), with concomitant produ...				Bioorg Med Chem 17: 284-94 (2009) Article DOI: 10.1016/j.bmc.2008.10.070 BindingDB Entry DOI: 10.7270/Q2FQ9TXB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM26411 (7-[(3,5-dimethoxyphenyl)amino]-5-{[(4-methoxypheny...) Show SMILES COc1ccc(CNc2nc(Nc3cc(OC)cc(OC)c3)c(C(N)=O)c3nccn23)cc1 Show InChI InChI=1S/C23H24N6O4/c1-31-16-6-4-14(5-7-16)13-26-23-28-21(19(20(24)30)22-25-8-9-29(22)23)27-15-10-17(32-2)12-18(11-15)33-3/h4-12,27H,13H2,1-3H3,(H2,24,30)(H,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	230	n/a	n/a	n/a	n/a	7.6	30
Kissei Pharmaceutical Company					Assay Description A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...				Bioorg Med Chem 17: 284-94 (2009) Article DOI: 10.1016/j.bmc.2008.10.070 BindingDB Entry DOI: 10.7270/Q2FQ9TXB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM26426 (2-{4-[({8-carbamoyl-7-[(3,5-dimethoxyphenyl)amino]...) Show SMILES COc1cc(Nc2nc(NCc3ccc(CC(O)=O)cc3)n3ccnc3c2C(N)=O)cc(OC)c1 Show InChI InChI=1S/C24H24N6O5/c1-34-17-10-16(11-18(12-17)35-2)28-22-20(21(25)33)23-26-7-8-30(23)24(29-22)27-13-15-5-3-14(4-6-15)9-19(31)32/h3-8,10-12,28H,9,13H2,1-2H3,(H2,25,33)(H,27,29)(H,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	240	n/a	n/a	n/a	n/a	7.6	30
Kissei Pharmaceutical Company					Assay Description A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...				Bioorg Med Chem 17: 284-94 (2009) Article DOI: 10.1016/j.bmc.2008.10.070 BindingDB Entry DOI: 10.7270/Q2FQ9TXB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM26416 (7-[(3,5-dimethoxyphenyl)amino]-5-[(pyridin-4-ylmet...) Show SMILES COc1cc(Nc2nc(NCc3ccncc3)n3ccnc3c2C(N)=O)cc(OC)c1 Show InChI InChI=1S/C21H21N7O3/c1-30-15-9-14(10-16(11-15)31-2)26-19-17(18(22)29)20-24-7-8-28(20)21(27-19)25-12-13-3-5-23-6-4-13/h3-11,26H,12H2,1-2H3,(H2,22,29)(H,25,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	7.6	30
Kissei Pharmaceutical Company					Assay Description A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...				Bioorg Med Chem 17: 284-94 (2009) Article DOI: 10.1016/j.bmc.2008.10.070 BindingDB Entry DOI: 10.7270/Q2FQ9TXB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM26413 (7-[(3,5-dimethoxyphenyl)amino]-5-{[(2-methoxypheny...) Show SMILES COc1cc(Nc2nc(NCc3ccccc3OC)n3ccnc3c2C(N)=O)cc(OC)c1 Show InChI InChI=1S/C23H24N6O4/c1-31-16-10-15(11-17(12-16)32-2)27-21-19(20(24)30)22-25-8-9-29(22)23(28-21)26-13-14-6-4-5-7-18(14)33-3/h4-12,27H,13H2,1-3H3,(H2,24,30)(H,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	340	n/a	n/a	n/a	n/a	7.6	30
Kissei Pharmaceutical Company					Assay Description A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...				Bioorg Med Chem 17: 284-94 (2009) Article DOI: 10.1016/j.bmc.2008.10.070 BindingDB Entry DOI: 10.7270/Q2FQ9TXB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM26405 (5-(benzylamino)-7-[(3,5-dimethoxyphenyl)amino]imid...) Show SMILES COc1cc(Nc2nc(NCc3ccccc3)n3ccnc3c2C(N)=O)cc(OC)c1 Show InChI InChI=1S/C22H22N6O3/c1-30-16-10-15(11-17(12-16)31-2)26-20-18(19(23)29)21-24-8-9-28(21)22(27-20)25-13-14-6-4-3-5-7-14/h3-12,26H,13H2,1-2H3,(H2,23,29)(H,25,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	7.6	30
Kissei Pharmaceutical Company					Assay Description A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...				Bioorg Med Chem 17: 284-94 (2009) Article DOI: 10.1016/j.bmc.2008.10.070 BindingDB Entry DOI: 10.7270/Q2FQ9TXB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM26408 (7-[(3,5-dimethoxyphenyl)amino]-5-{[(1R)-1-phenylet...) Show SMILES COc1cc(Nc2nc(N[C@H](C)c3ccccc3)n3ccnc3c2C(N)=O)cc(OC)c1 |r| Show InChI InChI=1S/C23H24N6O3/c1-14(15-7-5-4-6-8-15)26-23-28-21(19(20(24)30)22-25-9-10-29(22)23)27-16-11-17(31-2)13-18(12-16)32-3/h4-14,27H,1-3H3,(H2,24,30)(H,26,28)/t14-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	410	n/a	n/a	n/a	n/a	7.6	30
Kissei Pharmaceutical Company					Assay Description A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...				Bioorg Med Chem 17: 284-94 (2009) Article DOI: 10.1016/j.bmc.2008.10.070 BindingDB Entry DOI: 10.7270/Q2FQ9TXB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM26421 (imidazo[1,2-c]pyrimidine-8-carboxamide, 10t | meth...) Show SMILES COC(=O)c1ccc(CNc2nc(Nc3cc(OC)cc(OC)c3)c(C(N)=O)c3nccn23)cc1 Show InChI InChI=1S/C24H24N6O5/c1-33-17-10-16(11-18(12-17)34-2)28-21-19(20(25)31)22-26-8-9-30(22)24(29-21)27-13-14-4-6-15(7-5-14)23(32)35-3/h4-12,28H,13H2,1-3H3,(H2,25,31)(H,27,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	420	n/a	n/a	n/a	n/a	7.6	30
Kissei Pharmaceutical Company					Assay Description A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...				Bioorg Med Chem 17: 284-94 (2009) Article DOI: 10.1016/j.bmc.2008.10.070 BindingDB Entry DOI: 10.7270/Q2FQ9TXB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM26427 (5-({[4-(carbamoylmethyl)phenyl]methyl}amino)-7-[(3...) Show SMILES COc1cc(Nc2nc(NCc3ccc(CC(N)=O)cc3)n3ccnc3c2C(N)=O)cc(OC)c1 Show InChI InChI=1S/C24H25N7O4/c1-34-17-10-16(11-18(12-17)35-2)29-22-20(21(26)33)23-27-7-8-31(23)24(30-22)28-13-15-5-3-14(4-6-15)9-19(25)32/h3-8,10-12,29H,9,13H2,1-2H3,(H2,25,32)(H2,26,33)(H,28,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	480	n/a	n/a	n/a	n/a	7.6	30
Kissei Pharmaceutical Company					Assay Description A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...				Bioorg Med Chem 17: 284-94 (2009) Article DOI: 10.1016/j.bmc.2008.10.070 BindingDB Entry DOI: 10.7270/Q2FQ9TXB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM26412 (7-[(3,5-dimethoxyphenyl)amino]-5-{[(3-methoxypheny...) Show SMILES COc1cccc(CNc2nc(Nc3cc(OC)cc(OC)c3)c(C(N)=O)c3nccn23)c1 Show InChI InChI=1S/C23H24N6O4/c1-31-16-6-4-5-14(9-16)13-26-23-28-21(19(20(24)30)22-25-7-8-29(22)23)27-15-10-17(32-2)12-18(11-15)33-3/h4-12,27H,13H2,1-3H3,(H2,24,30)(H,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	530	n/a	n/a	n/a	n/a	7.6	30
Kissei Pharmaceutical Company					Assay Description A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...				Bioorg Med Chem 17: 284-94 (2009) Article DOI: 10.1016/j.bmc.2008.10.070 BindingDB Entry DOI: 10.7270/Q2FQ9TXB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM26423 (5-{[(4-carbamoylphenyl)methyl]amino}-7-[(3,5-dimet...) Show SMILES COc1cc(Nc2nc(NCc3ccc(cc3)C(N)=O)n3ccnc3c2C(N)=O)cc(OC)c1 Show InChI InChI=1S/C23H23N7O4/c1-33-16-9-15(10-17(11-16)34-2)28-21-18(20(25)32)22-26-7-8-30(22)23(29-21)27-12-13-3-5-14(6-4-13)19(24)31/h3-11,28H,12H2,1-2H3,(H2,24,31)(H2,25,32)(H,27,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	660	n/a	n/a	n/a	n/a	7.6	30
Kissei Pharmaceutical Company					Assay Description A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...				Bioorg Med Chem 17: 284-94 (2009) Article DOI: 10.1016/j.bmc.2008.10.070 BindingDB Entry DOI: 10.7270/Q2FQ9TXB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM26429 ((2E)-3-{4-[({8-carbamoyl-7-[(3,5-dimethoxyphenyl)a...) Show SMILES COc1cc(Nc2nc(NCc3ccc(\C=C\C(O)=O)cc3)n3ccnc3c2C(N)=O)cc(OC)c1 Show InChI InChI=1S/C25H24N6O5/c1-35-18-11-17(12-19(13-18)36-2)29-23-21(22(26)34)24-27-9-10-31(24)25(30-23)28-14-16-5-3-15(4-6-16)7-8-20(32)33/h3-13,29H,14H2,1-2H3,(H2,26,34)(H,28,30)(H,32,33)/b8-7+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	690	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Company					Assay Description A coupled spectrophotometric assay was used, wherein ADP generated by Syk kinase was converted to ATP by pyruvate kinase (PK), with concomitant produ...				Bioorg Med Chem 17: 284-94 (2009) Article DOI: 10.1016/j.bmc.2008.10.070 BindingDB Entry DOI: 10.7270/Q2FQ9TXB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM26424 (7-[(3,5-dimethoxyphenyl)amino]-5-({[4-(hydroxymeth...) Show SMILES COc1cc(Nc2nc(NCc3ccc(CO)cc3)n3ccnc3c2C(N)=O)cc(OC)c1 Show InChI InChI=1S/C23H24N6O4/c1-32-17-9-16(10-18(11-17)33-2)27-21-19(20(24)31)22-25-7-8-29(22)23(28-21)26-12-14-3-5-15(13-30)6-4-14/h3-11,27,30H,12-13H2,1-2H3,(H2,24,31)(H,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	690	n/a	n/a	n/a	n/a	7.6	30
Kissei Pharmaceutical Company					Assay Description A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...				Bioorg Med Chem 17: 284-94 (2009) Article DOI: 10.1016/j.bmc.2008.10.070 BindingDB Entry DOI: 10.7270/Q2FQ9TXB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM26426 (2-{4-[({8-carbamoyl-7-[(3,5-dimethoxyphenyl)amino]...) Show SMILES COc1cc(Nc2nc(NCc3ccc(CC(O)=O)cc3)n3ccnc3c2C(N)=O)cc(OC)c1 Show InChI InChI=1S/C24H24N6O5/c1-34-17-10-16(11-18(12-17)35-2)28-22-20(21(25)33)23-26-7-8-30(23)24(29-22)27-13-15-5-3-14(4-6-15)9-19(31)32/h3-8,10-12,28H,9,13H2,1-2H3,(H2,25,33)(H,27,29)(H,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	760	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Company					Assay Description A coupled spectrophotometric assay was used, wherein ADP generated by Syk kinase was converted to ATP by pyruvate kinase (PK), with concomitant produ...				Bioorg Med Chem 17: 284-94 (2009) Article DOI: 10.1016/j.bmc.2008.10.070 BindingDB Entry DOI: 10.7270/Q2FQ9TXB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM26414 (5-{[(3,5-difluorophenyl)methyl]amino}-7-[(3,5-dime...) Show SMILES COc1cc(Nc2nc(NCc3cc(F)cc(F)c3)n3ccnc3c2C(N)=O)cc(OC)c1 Show InChI InChI=1S/C22H20F2N6O3/c1-32-16-8-15(9-17(10-16)33-2)28-20-18(19(25)31)21-26-3-4-30(21)22(29-20)27-11-12-5-13(23)7-14(24)6-12/h3-10,28H,11H2,1-2H3,(H2,25,31)(H,27,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	910	n/a	n/a	n/a	n/a	7.6	30
Kissei Pharmaceutical Company					Assay Description A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...				Bioorg Med Chem 17: 284-94 (2009) Article DOI: 10.1016/j.bmc.2008.10.070 BindingDB Entry DOI: 10.7270/Q2FQ9TXB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM26417 (7-[(3,5-dimethoxyphenyl)amino]-5-[(furan-2-ylmethy...) Show SMILES COc1cc(Nc2nc(NCc3ccco3)n3ccnc3c2C(N)=O)cc(OC)c1 Show InChI InChI=1S/C20H20N6O4/c1-28-14-8-12(9-15(10-14)29-2)24-18-16(17(21)27)19-22-5-6-26(19)20(25-18)23-11-13-4-3-7-30-13/h3-10,24H,11H2,1-2H3,(H2,21,27)(H,23,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	920	n/a	n/a	n/a	n/a	7.6	30
Kissei Pharmaceutical Company					Assay Description A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...				Bioorg Med Chem 17: 284-94 (2009) Article DOI: 10.1016/j.bmc.2008.10.070 BindingDB Entry DOI: 10.7270/Q2FQ9TXB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM26409 (7-[(3,5-dimethoxyphenyl)amino]-5-{[(1S)-1-phenylet...) Show SMILES COc1cc(Nc2nc(N[C@@H](C)c3ccccc3)n3ccnc3c2C(N)=O)cc(OC)c1 |r| Show InChI InChI=1S/C23H24N6O3/c1-14(15-7-5-4-6-8-15)26-23-28-21(19(20(24)30)22-25-9-10-29(22)23)27-16-11-17(31-2)13-18(12-16)32-3/h4-14,27H,1-3H3,(H2,24,30)(H,26,28)/t14-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	930	n/a	n/a	n/a	n/a	7.6	30
Kissei Pharmaceutical Company					Assay Description A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...				Bioorg Med Chem 17: 284-94 (2009) Article DOI: 10.1016/j.bmc.2008.10.070 BindingDB Entry DOI: 10.7270/Q2FQ9TXB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM26427 (5-({[4-(carbamoylmethyl)phenyl]methyl}amino)-7-[(3...) Show SMILES COc1cc(Nc2nc(NCc3ccc(CC(N)=O)cc3)n3ccnc3c2C(N)=O)cc(OC)c1 Show InChI InChI=1S/C24H25N7O4/c1-34-17-10-16(11-18(12-17)35-2)29-22-20(21(26)33)23-27-7-8-31(23)24(30-22)28-13-15-5-3-14(4-6-15)9-19(25)32/h3-8,10-12,29H,9,13H2,1-2H3,(H2,25,32)(H2,26,33)(H,28,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Company					Assay Description A coupled spectrophotometric assay was used, wherein ADP generated by Syk kinase was converted to ATP by pyruvate kinase (PK), with concomitant produ...				Bioorg Med Chem 17: 284-94 (2009) Article DOI: 10.1016/j.bmc.2008.10.070 BindingDB Entry DOI: 10.7270/Q2FQ9TXB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM26410 (7-[(3,5-dimethoxyphenyl)amino]-5-{[(4-fluorophenyl...) Show SMILES COc1cc(Nc2nc(NCc3ccc(F)cc3)n3ccnc3c2C(N)=O)cc(OC)c1 Show InChI InChI=1S/C22H21FN6O3/c1-31-16-9-15(10-17(11-16)32-2)27-20-18(19(24)30)21-25-7-8-29(21)22(28-20)26-12-13-3-5-14(23)6-4-13/h3-11,27H,12H2,1-2H3,(H2,24,30)(H,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Company					Assay Description A coupled spectrophotometric assay was used, wherein ADP generated by Syk kinase was converted to ATP by pyruvate kinase (PK), with concomitant produ...				Bioorg Med Chem 17: 284-94 (2009) Article DOI: 10.1016/j.bmc.2008.10.070 BindingDB Entry DOI: 10.7270/Q2FQ9TXB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM26403 (7-[(3,5-dimethoxyphenyl)amino]-5-[(2-hydroxyethyl)...) Show SMILES COc1cc(Nc2nc(NCCO)n3ccnc3c2C(N)=O)cc(OC)c1 Show InChI InChI=1S/C17H20N6O4/c1-26-11-7-10(8-12(9-11)27-2)21-15-13(14(18)25)16-19-3-5-23(16)17(22-15)20-4-6-24/h3,5,7-9,21,24H,4,6H2,1-2H3,(H2,18,25)(H,20,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	7.6	30
Kissei Pharmaceutical Company					Assay Description A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...				Bioorg Med Chem 17: 284-94 (2009) Article DOI: 10.1016/j.bmc.2008.10.070 BindingDB Entry DOI: 10.7270/Q2FQ9TXB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM26416 (7-[(3,5-dimethoxyphenyl)amino]-5-[(pyridin-4-ylmet...) Show SMILES COc1cc(Nc2nc(NCc3ccncc3)n3ccnc3c2C(N)=O)cc(OC)c1 Show InChI InChI=1S/C21H21N7O3/c1-30-15-9-14(10-16(11-15)31-2)26-19-17(18(22)29)20-24-7-8-28(20)21(27-19)25-12-13-3-5-23-6-4-13/h3-11,26H,12H2,1-2H3,(H2,22,29)(H,25,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Company					Assay Description A coupled spectrophotometric assay was used, wherein ADP generated by Syk kinase was converted to ATP by pyruvate kinase (PK), with concomitant produ...				Bioorg Med Chem 17: 284-94 (2009) Article DOI: 10.1016/j.bmc.2008.10.070 BindingDB Entry DOI: 10.7270/Q2FQ9TXB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM26417 (7-[(3,5-dimethoxyphenyl)amino]-5-[(furan-2-ylmethy...) Show SMILES COc1cc(Nc2nc(NCc3ccco3)n3ccnc3c2C(N)=O)cc(OC)c1 Show InChI InChI=1S/C20H20N6O4/c1-28-14-8-12(9-15(10-14)29-2)24-18-16(17(21)27)19-22-5-6-26(19)20(25-18)23-11-13-4-3-7-30-13/h3-10,24H,11H2,1-2H3,(H2,21,27)(H,23,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Company					Assay Description A coupled spectrophotometric assay was used, wherein ADP generated by Syk kinase was converted to ATP by pyruvate kinase (PK), with concomitant produ...				Bioorg Med Chem 17: 284-94 (2009) Article DOI: 10.1016/j.bmc.2008.10.070 BindingDB Entry DOI: 10.7270/Q2FQ9TXB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM26401 (7-[(3,5-dimethoxyphenyl)amino]-5-(methylsulfanyl)i...) Show SMILES COc1cc(Nc2nc(SC)n3ccnc3c2C(N)=O)cc(OC)c1 Show InChI InChI=1S/C16H17N5O3S/c1-23-10-6-9(7-11(8-10)24-2)19-14-12(13(17)22)15-18-4-5-21(15)16(20-14)25-3/h4-8,19H,1-3H3,(H2,17,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	7.6	30
Kissei Pharmaceutical Company					Assay Description A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...				Bioorg Med Chem 17: 284-94 (2009) Article DOI: 10.1016/j.bmc.2008.10.070 BindingDB Entry DOI: 10.7270/Q2FQ9TXB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM26425 (imidazo[1,2-c]pyrimidine-8-carboxamide, 20 | tert-...) Show SMILES COc1cc(Nc2nc(NCc3ccc(CC(=O)OC(C)(C)C)cc3)n3ccnc3c2C(N)=O)cc(OC)c1 Show InChI InChI=1S/C28H32N6O5/c1-28(2,3)39-22(35)12-17-6-8-18(9-7-17)16-31-27-33-25(23(24(29)36)26-30-10-11-34(26)27)32-19-13-20(37-4)15-21(14-19)38-5/h6-11,13-15,32H,12,16H2,1-5H3,(H2,29,36)(H,31,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	7.6	30
Kissei Pharmaceutical Company					Assay Description A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...				Bioorg Med Chem 17: 284-94 (2009) Article DOI: 10.1016/j.bmc.2008.10.070 BindingDB Entry DOI: 10.7270/Q2FQ9TXB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM26409 (7-[(3,5-dimethoxyphenyl)amino]-5-{[(1S)-1-phenylet...) Show SMILES COc1cc(Nc2nc(N[C@@H](C)c3ccccc3)n3ccnc3c2C(N)=O)cc(OC)c1 |r| Show InChI InChI=1S/C23H24N6O3/c1-14(15-7-5-4-6-8-15)26-23-28-21(19(20(24)30)22-25-9-10-29(22)23)27-16-11-17(31-2)13-18(12-16)32-3/h4-14,27H,1-3H3,(H2,24,30)(H,26,28)/t14-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Company					Assay Description A coupled spectrophotometric assay was used, wherein ADP generated by Syk kinase was converted to ATP by pyruvate kinase (PK), with concomitant produ...				Bioorg Med Chem 17: 284-94 (2009) Article DOI: 10.1016/j.bmc.2008.10.070 BindingDB Entry DOI: 10.7270/Q2FQ9TXB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM26404 (5-[(2-aminoethyl)amino]-7-[(3,5-dimethoxyphenyl)am...) Show SMILES COc1cc(Nc2nc(NCCN)n3ccnc3c2C(N)=O)cc(OC)c1 Show InChI InChI=1S/C17H21N7O3/c1-26-11-7-10(8-12(9-11)27-2)22-15-13(14(19)25)16-20-5-6-24(16)17(23-15)21-4-3-18/h5-9,22H,3-4,18H2,1-2H3,(H2,19,25)(H,21,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a	7.6	30
Kissei Pharmaceutical Company					Assay Description A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...				Bioorg Med Chem 17: 284-94 (2009) Article DOI: 10.1016/j.bmc.2008.10.070 BindingDB Entry DOI: 10.7270/Q2FQ9TXB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM26415 (5-{[(2,4-difluorophenyl)methyl]amino}-7-[(3,5-dime...) Show SMILES COc1cc(Nc2nc(NCc3ccc(F)cc3F)n3ccnc3c2C(N)=O)cc(OC)c1 Show InChI InChI=1S/C22H20F2N6O3/c1-32-15-8-14(9-16(10-15)33-2)28-20-18(19(25)31)21-26-5-6-30(21)22(29-20)27-11-12-3-4-13(23)7-17(12)24/h3-10,28H,11H2,1-2H3,(H2,25,31)(H,27,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Company					Assay Description A coupled spectrophotometric assay was used, wherein ADP generated by Syk kinase was converted to ATP by pyruvate kinase (PK), with concomitant produ...				Bioorg Med Chem 17: 284-94 (2009) Article DOI: 10.1016/j.bmc.2008.10.070 BindingDB Entry DOI: 10.7270/Q2FQ9TXB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM26405 (5-(benzylamino)-7-[(3,5-dimethoxyphenyl)amino]imid...) Show SMILES COc1cc(Nc2nc(NCc3ccccc3)n3ccnc3c2C(N)=O)cc(OC)c1 Show InChI InChI=1S/C22H22N6O3/c1-30-16-10-15(11-17(12-16)31-2)26-20-18(19(23)29)21-24-8-9-28(21)22(27-20)25-13-14-6-4-3-5-7-14/h3-12,26H,13H2,1-2H3,(H2,23,29)(H,25,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Company					Assay Description A coupled spectrophotometric assay was used, wherein ADP generated by Syk kinase was converted to ATP by pyruvate kinase (PK), with concomitant produ...				Bioorg Med Chem 17: 284-94 (2009) Article DOI: 10.1016/j.bmc.2008.10.070 BindingDB Entry DOI: 10.7270/Q2FQ9TXB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM26403 (7-[(3,5-dimethoxyphenyl)amino]-5-[(2-hydroxyethyl)...) Show SMILES COc1cc(Nc2nc(NCCO)n3ccnc3c2C(N)=O)cc(OC)c1 Show InChI InChI=1S/C17H20N6O4/c1-26-11-7-10(8-12(9-11)27-2)21-15-13(14(18)25)16-19-3-5-23(16)17(22-15)20-4-6-24/h3,5,7-9,21,24H,4,6H2,1-2H3,(H2,18,25)(H,20,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Company					Assay Description A coupled spectrophotometric assay was used, wherein ADP generated by Syk kinase was converted to ATP by pyruvate kinase (PK), with concomitant produ...				Bioorg Med Chem 17: 284-94 (2009) Article DOI: 10.1016/j.bmc.2008.10.070 BindingDB Entry DOI: 10.7270/Q2FQ9TXB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM26421 (imidazo[1,2-c]pyrimidine-8-carboxamide, 10t | meth...) Show SMILES COC(=O)c1ccc(CNc2nc(Nc3cc(OC)cc(OC)c3)c(C(N)=O)c3nccn23)cc1 Show InChI InChI=1S/C24H24N6O5/c1-33-17-10-16(11-18(12-17)34-2)28-21-19(20(25)31)22-26-8-9-30(22)24(29-21)27-13-14-4-6-15(7-5-14)23(32)35-3/h4-12,28H,13H2,1-3H3,(H2,25,31)(H,27,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Company					Assay Description A coupled spectrophotometric assay was used, wherein ADP generated by Syk kinase was converted to ATP by pyruvate kinase (PK), with concomitant produ...				Bioorg Med Chem 17: 284-94 (2009) Article DOI: 10.1016/j.bmc.2008.10.070 BindingDB Entry DOI: 10.7270/Q2FQ9TXB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM26407 (7-[(3,5-dimethoxyphenyl)amino]-5-[(2-phenylethyl)a...) Show SMILES COc1cc(Nc2nc(NCCc3ccccc3)n3ccnc3c2C(N)=O)cc(OC)c1 Show InChI InChI=1S/C23H24N6O3/c1-31-17-12-16(13-18(14-17)32-2)27-21-19(20(24)30)22-25-10-11-29(22)23(28-21)26-9-8-15-6-4-3-5-7-15/h3-7,10-14,27H,8-9H2,1-2H3,(H2,24,30)(H,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Company					Assay Description A coupled spectrophotometric assay was used, wherein ADP generated by Syk kinase was converted to ATP by pyruvate kinase (PK), with concomitant produ...				Bioorg Med Chem 17: 284-94 (2009) Article DOI: 10.1016/j.bmc.2008.10.070 BindingDB Entry DOI: 10.7270/Q2FQ9TXB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM26407 (7-[(3,5-dimethoxyphenyl)amino]-5-[(2-phenylethyl)a...) Show SMILES COc1cc(Nc2nc(NCCc3ccccc3)n3ccnc3c2C(N)=O)cc(OC)c1 Show InChI InChI=1S/C23H24N6O3/c1-31-17-12-16(13-18(14-17)32-2)27-21-19(20(24)30)22-25-10-11-29(22)23(28-21)26-9-8-15-6-4-3-5-7-15/h3-7,10-14,27H,8-9H2,1-2H3,(H2,24,30)(H,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.10E+3	n/a	n/a	n/a	n/a	7.6	30
Kissei Pharmaceutical Company					Assay Description A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...				Bioorg Med Chem 17: 284-94 (2009) Article DOI: 10.1016/j.bmc.2008.10.070 BindingDB Entry DOI: 10.7270/Q2FQ9TXB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM26406 (5-[benzyl(methyl)amino]-7-[(3,5-dimethoxyphenyl)am...) Show SMILES COc1cc(Nc2nc(N(C)Cc3ccccc3)n3ccnc3c2C(N)=O)cc(OC)c1 Show InChI InChI=1S/C23H24N6O3/c1-28(14-15-7-5-4-6-8-15)23-27-21(19(20(24)30)22-25-9-10-29(22)23)26-16-11-17(31-2)13-18(12-16)32-3/h4-13,26H,14H2,1-3H3,(H2,24,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	7.6	30
Kissei Pharmaceutical Company					Assay Description A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...				Bioorg Med Chem 17: 284-94 (2009) Article DOI: 10.1016/j.bmc.2008.10.070 BindingDB Entry DOI: 10.7270/Q2FQ9TXB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM26413 (7-[(3,5-dimethoxyphenyl)amino]-5-{[(2-methoxypheny...) Show SMILES COc1cc(Nc2nc(NCc3ccccc3OC)n3ccnc3c2C(N)=O)cc(OC)c1 Show InChI InChI=1S/C23H24N6O4/c1-31-16-10-15(11-17(12-16)32-2)27-21-19(20(24)30)22-25-8-9-29(22)23(28-21)26-13-14-6-4-5-7-18(14)33-3/h4-12,27H,13H2,1-3H3,(H2,24,30)(H,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Company					Assay Description A coupled spectrophotometric assay was used, wherein ADP generated by Syk kinase was converted to ATP by pyruvate kinase (PK), with concomitant produ...				Bioorg Med Chem 17: 284-94 (2009) Article DOI: 10.1016/j.bmc.2008.10.070 BindingDB Entry DOI: 10.7270/Q2FQ9TXB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM26412 (7-[(3,5-dimethoxyphenyl)amino]-5-{[(3-methoxypheny...) Show SMILES COc1cccc(CNc2nc(Nc3cc(OC)cc(OC)c3)c(C(N)=O)c3nccn23)c1 Show InChI InChI=1S/C23H24N6O4/c1-31-16-6-4-5-14(9-16)13-26-23-28-21(19(20(24)30)22-25-7-8-29(22)23)27-15-10-17(32-2)12-18(11-15)33-3/h4-12,27H,13H2,1-3H3,(H2,24,30)(H,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Company					Assay Description A coupled spectrophotometric assay was used, wherein ADP generated by Syk kinase was converted to ATP by pyruvate kinase (PK), with concomitant produ...				Bioorg Med Chem 17: 284-94 (2009) Article DOI: 10.1016/j.bmc.2008.10.070 BindingDB Entry DOI: 10.7270/Q2FQ9TXB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM26402 (5-amino-7-[(3,5-dimethoxyphenyl)amino]imidazo[1,2-...) Show SMILES COc1cc(Nc2nc(N)n3ccnc3c2C(N)=O)cc(OC)c1 Show InChI InChI=1S/C15H16N6O3/c1-23-9-5-8(6-10(7-9)24-2)19-13-11(12(16)22)14-18-3-4-21(14)15(17)20-13/h3-7,19H,1-2H3,(H2,16,22)(H2,17,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Company					Assay Description A coupled spectrophotometric assay was used, wherein ADP generated by Syk kinase was converted to ATP by pyruvate kinase (PK), with concomitant produ...				Bioorg Med Chem 17: 284-94 (2009) Article DOI: 10.1016/j.bmc.2008.10.070 BindingDB Entry DOI: 10.7270/Q2FQ9TXB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM26422 (4-[({8-carbamoyl-7-[(3,5-dimethoxyphenyl)amino]imi...) Show SMILES COc1cc(Nc2nc(NCc3ccc(cc3)C(O)=O)n3ccnc3c2C(N)=O)cc(OC)c1 Show InChI InChI=1S/C23H22N6O5/c1-33-16-9-15(10-17(11-16)34-2)27-20-18(19(24)30)21-25-7-8-29(21)23(28-20)26-12-13-3-5-14(6-4-13)22(31)32/h3-11,27H,12H2,1-2H3,(H2,24,30)(H,26,28)(H,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Company					Assay Description A coupled spectrophotometric assay was used, wherein ADP generated by Syk kinase was converted to ATP by pyruvate kinase (PK), with concomitant produ...				Bioorg Med Chem 17: 284-94 (2009) Article DOI: 10.1016/j.bmc.2008.10.070 BindingDB Entry DOI: 10.7270/Q2FQ9TXB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM26424 (7-[(3,5-dimethoxyphenyl)amino]-5-({[4-(hydroxymeth...) Show SMILES COc1cc(Nc2nc(NCc3ccc(CO)cc3)n3ccnc3c2C(N)=O)cc(OC)c1 Show InChI InChI=1S/C23H24N6O4/c1-32-17-9-16(10-18(11-17)33-2)27-21-19(20(24)31)22-25-7-8-29(22)23(28-21)26-12-14-3-5-15(13-30)6-4-14/h3-11,27,30H,12-13H2,1-2H3,(H2,24,31)(H,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Company					Assay Description A coupled spectrophotometric assay was used, wherein ADP generated by Syk kinase was converted to ATP by pyruvate kinase (PK), with concomitant produ...				Bioorg Med Chem 17: 284-94 (2009) Article DOI: 10.1016/j.bmc.2008.10.070 BindingDB Entry DOI: 10.7270/Q2FQ9TXB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM26423 (5-{[(4-carbamoylphenyl)methyl]amino}-7-[(3,5-dimet...) Show SMILES COc1cc(Nc2nc(NCc3ccc(cc3)C(N)=O)n3ccnc3c2C(N)=O)cc(OC)c1 Show InChI InChI=1S/C23H23N7O4/c1-33-16-9-15(10-17(11-16)34-2)28-21-18(20(25)32)22-26-7-8-30(22)23(29-21)27-12-13-3-5-14(6-4-13)19(24)31/h3-11,28H,12H2,1-2H3,(H2,24,31)(H2,25,32)(H,27,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Company					Assay Description A coupled spectrophotometric assay was used, wherein ADP generated by Syk kinase was converted to ATP by pyruvate kinase (PK), with concomitant produ...				Bioorg Med Chem 17: 284-94 (2009) Article DOI: 10.1016/j.bmc.2008.10.070 BindingDB Entry DOI: 10.7270/Q2FQ9TXB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM26418 (5-[(1H-1,3-benzodiazol-2-ylmethyl)amino]-7-[(3,5-d...) Show SMILES COc1cc(Nc2nc(NCc3nc4ccccc4[nH]3)n3ccnc3c2C(N)=O)cc(OC)c1 Show InChI InChI=1S/C23H22N8O3/c1-33-14-9-13(10-15(11-14)34-2)27-21-19(20(24)32)22-25-7-8-31(22)23(30-21)26-12-18-28-16-5-3-4-6-17(16)29-18/h3-11,27H,12H2,1-2H3,(H2,24,32)(H,26,30)(H,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Company					Assay Description A coupled spectrophotometric assay was used, wherein ADP generated by Syk kinase was converted to ATP by pyruvate kinase (PK), with concomitant produ...				Bioorg Med Chem 17: 284-94 (2009) Article DOI: 10.1016/j.bmc.2008.10.070 BindingDB Entry DOI: 10.7270/Q2FQ9TXB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM26414 (5-{[(3,5-difluorophenyl)methyl]amino}-7-[(3,5-dime...) Show SMILES COc1cc(Nc2nc(NCc3cc(F)cc(F)c3)n3ccnc3c2C(N)=O)cc(OC)c1 Show InChI InChI=1S/C22H20F2N6O3/c1-32-16-8-15(9-17(10-16)33-2)28-20-18(19(25)31)21-26-3-4-30(21)22(29-20)27-11-12-5-13(23)7-14(24)6-12/h3-10,28H,11H2,1-2H3,(H2,25,31)(H,27,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Company					Assay Description A coupled spectrophotometric assay was used, wherein ADP generated by Syk kinase was converted to ATP by pyruvate kinase (PK), with concomitant produ...				Bioorg Med Chem 17: 284-94 (2009) Article DOI: 10.1016/j.bmc.2008.10.070 BindingDB Entry DOI: 10.7270/Q2FQ9TXB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM26419 (7-[(3,5-dimethoxyphenyl)amino]-5-{[(4-sulfamoylphe...) Show SMILES COc1cc(Nc2nc(NCc3ccc(cc3)S(N)(=O)=O)n3ccnc3c2C(N)=O)cc(OC)c1 Show InChI InChI=1S/C22H23N7O5S/c1-33-15-9-14(10-16(11-15)34-2)27-20-18(19(23)30)21-25-7-8-29(21)22(28-20)26-12-13-3-5-17(6-4-13)35(24,31)32/h3-11,27H,12H2,1-2H3,(H2,23,30)(H,26,28)(H2,24,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Company					Assay Description A coupled spectrophotometric assay was used, wherein ADP generated by Syk kinase was converted to ATP by pyruvate kinase (PK), with concomitant produ...				Bioorg Med Chem 17: 284-94 (2009) Article DOI: 10.1016/j.bmc.2008.10.070 BindingDB Entry DOI: 10.7270/Q2FQ9TXB
					More data for this Ligand-Target Pair

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