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Compile Data Set for Download or QSAR

Found 42 hits Enz. Inhib. hit(s) with all data for assayid = 5 entry = 50027751   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))
BDBM50273512
PNG
(1-[4-Difluoromethoxy-3-(tetrahydrofuran-3-yloxy)ph...)
Show SMILES CC(C)CC(=O)c1ccc(OC(F)F)c(OC2CCOC2)c1
Show InChI InChI=1S/C16H20F2O4/c1-10(2)7-13(19)11-3-4-14(22-16(17)18)15(8-11)21-12-5-6-20-9-12/h3-4,8,10,12,16H,5-7,9H2,1-2H3
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n/an/a 26n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of full length human PDE4D2 expressed in Escherichia coli BL21 by liquid scintillation counting


J Med Chem 51: 7673-88 (2008)


Article DOI: 10.1021/jm701635j
BindingDB Entry DOI: 10.7270/Q2736QRN
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))
BDBM50273572
PNG
(1-(3-Cyclopentyloxy-4-difluoromethoxyphenyl]-3-met...)
Show SMILES CC(C)CC(=O)c1ccc(OC(F)F)c(OC2CCCC2)c1
Show InChI InChI=1S/C17H22F2O3/c1-11(2)9-14(20)12-7-8-15(22-17(18)19)16(10-12)21-13-5-3-4-6-13/h7-8,10-11,13,17H,3-6,9H2,1-2H3
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n/an/a 28n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of full length human PDE4D2 expressed in Escherichia coli BL21 by liquid scintillation counting


J Med Chem 51: 7673-88 (2008)


Article DOI: 10.1021/jm701635j
BindingDB Entry DOI: 10.7270/Q2736QRN
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))
BDBM50273545
PNG
(1-[4-Difluoromethoxy-3-(tetrahydrofuran-3-yloxy)ph...)
Show SMILES CCCCC(=O)c1ccc(OC(F)F)c(OC2CCOC2)c1
Show InChI InChI=1S/C16H20F2O4/c1-2-3-4-13(19)11-5-6-14(22-16(17)18)15(9-11)21-12-7-8-20-10-12/h5-6,9,12,16H,2-4,7-8,10H2,1H3
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n/an/a 62n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of full length human PDE4D2 expressed in Escherichia coli BL21 by liquid scintillation counting


J Med Chem 51: 7673-88 (2008)


Article DOI: 10.1021/jm701635j
BindingDB Entry DOI: 10.7270/Q2736QRN
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))
BDBM50273577
PNG
(1-[4-Methoxy-3-(tetrahydrofuran-3-yloxy)phenyl]-3-...)
Show SMILES COc1ccc(cc1OC1CCOC1)C(=O)CC(C)C
Show InChI InChI=1S/C16H22O4/c1-11(2)8-14(17)12-4-5-15(18-3)16(9-12)20-13-6-7-19-10-13/h4-5,9,11,13H,6-8,10H2,1-3H3
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n/an/a 178n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of full length human PDE4D2 expressed in Escherichia coli BL21 by liquid scintillation counting


J Med Chem 51: 7673-88 (2008)


Article DOI: 10.1021/jm701635j
BindingDB Entry DOI: 10.7270/Q2736QRN
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))
BDBM50273544
PNG
(1-[4-Difluoromethoxy-3-(tetrahydrofuran-3-yloxy)ph...)
Show SMILES FC(F)Oc1ccc(cc1OC1CCOC1)C(=O)CCc1ccccc1
Show InChI InChI=1S/C20H20F2O4/c21-20(22)26-18-9-7-15(12-19(18)25-16-10-11-24-13-16)17(23)8-6-14-4-2-1-3-5-14/h1-5,7,9,12,16,20H,6,8,10-11,13H2
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n/an/a 182n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of full length human PDE4D2 expressed in Escherichia coli BL21 by liquid scintillation counting


J Med Chem 51: 7673-88 (2008)


Article DOI: 10.1021/jm701635j
BindingDB Entry DOI: 10.7270/Q2736QRN
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))
BDBM50273334
PNG
(1-[4-Methoxy-3-(tetrahydrofuran-3-yloxy)phenyl]pen...)
Show SMILES CCCCC(=O)c1ccc(OC)c(OC2CCOC2)c1
Show InChI InChI=1S/C16H22O4/c1-3-4-5-14(17)12-6-7-15(18-2)16(10-12)20-13-8-9-19-11-13/h6-7,10,13H,3-5,8-9,11H2,1-2H3
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n/an/a 200n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of full length human PDE4D2 expressed in Escherichia coli BL21 by liquid scintillation counting


J Med Chem 51: 7673-88 (2008)


Article DOI: 10.1021/jm701635j
BindingDB Entry DOI: 10.7270/Q2736QRN
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))
BDBM50273511
PNG
(1-[4-Difluoromethoxy-3-(tetrahydropyran-4-yloxy)ph...)
Show SMILES CCCC(=O)c1ccc(OC(F)F)c(OC2CCOCC2)c1
Show InChI InChI=1S/C16H20F2O4/c1-2-3-13(19)11-4-5-14(22-16(17)18)15(10-11)21-12-6-8-20-9-7-12/h4-5,10,12,16H,2-3,6-9H2,1H3
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n/an/a 347n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of full length human PDE4D2 expressed in Escherichia coli BL21 by liquid scintillation counting


J Med Chem 51: 7673-88 (2008)


Article DOI: 10.1021/jm701635j
BindingDB Entry DOI: 10.7270/Q2736QRN
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))
BDBM50273600
PNG
(1-[4-Methoxy-3-(tetrahydrofuran-3-yloxy)phenyl]-4-...)
Show SMILES COc1ccc(cc1OC1CCOC1)C(=O)CCC(C)C
Show InChI InChI=1S/C17H24O4/c1-12(2)4-6-15(18)13-5-7-16(19-3)17(10-13)21-14-8-9-20-11-14/h5,7,10,12,14H,4,6,8-9,11H2,1-3H3
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n/an/a 380n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of full length human PDE4D2 expressed in Escherichia coli BL21 by liquid scintillation counting


J Med Chem 51: 7673-88 (2008)


Article DOI: 10.1021/jm701635j
BindingDB Entry DOI: 10.7270/Q2736QRN
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))
BDBM50273335
PNG
(1-[4-Methoxy-3-(tetrahydrofuran-3-yloxy)phenyl]but...)
Show SMILES CCCC(=O)c1ccc(OC)c(OC2CCOC2)c1
Show InChI InChI=1S/C15H20O4/c1-3-4-13(16)11-5-6-14(17-2)15(9-11)19-12-7-8-18-10-12/h5-6,9,12H,3-4,7-8,10H2,1-2H3
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n/an/a 398n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of full length human PDE4D2 expressed in Escherichia coli BL21 by liquid scintillation counting


J Med Chem 51: 7673-88 (2008)


Article DOI: 10.1021/jm701635j
BindingDB Entry DOI: 10.7270/Q2736QRN
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))
BDBM50273576
PNG
(1-[4-Difluoromethoxy-3-(tetrahydrofuran-3-yloxy)ph...)
Show SMILES CC(C)(C)C(=O)c1ccc(OC(F)F)c(OC2CCOC2)c1
Show InChI InChI=1S/C16H20F2O4/c1-16(2,3)14(19)10-4-5-12(22-15(17)18)13(8-10)21-11-6-7-20-9-11/h4-5,8,11,15H,6-7,9H2,1-3H3
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n/an/a 407n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of full length human PDE4D2 expressed in Escherichia coli BL21 by liquid scintillation counting


J Med Chem 51: 7673-88 (2008)


Article DOI: 10.1021/jm701635j
BindingDB Entry DOI: 10.7270/Q2736QRN
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))
BDBM14361
PNG
((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Show SMILES COc1ccc(cc1OC1CCCC1)C1CNC(=O)C1
Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)
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n/an/a 550n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of full length human PDE4D2 expressed in Escherichia coli BL21 by liquid scintillation counting


J Med Chem 51: 7673-88 (2008)


Article DOI: 10.1021/jm701635j
BindingDB Entry DOI: 10.7270/Q2736QRN
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))
BDBM50273575
PNG
(1-[4-Difluoromethoxy-3-(tetrahydrofuran-3-yloxy)ph...)
Show SMILES FC(F)Oc1ccc(cc1OC1CCOC1)C(=O)CCCc1ccccc1
Show InChI InChI=1S/C21H22F2O4/c22-21(23)27-19-10-9-16(13-20(19)26-17-11-12-25-14-17)18(24)8-4-7-15-5-2-1-3-6-15/h1-3,5-6,9-10,13,17,21H,4,7-8,11-12,14H2
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n/an/a 631n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of full length human PDE4D2 expressed in Escherichia coli BL21 by liquid scintillation counting


J Med Chem 51: 7673-88 (2008)


Article DOI: 10.1021/jm701635j
BindingDB Entry DOI: 10.7270/Q2736QRN
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))
BDBM50273574
PNG
(2-Cyclohexyl-1-[4-difluoromethoxy-3-(tetrahydrofur...)
Show SMILES FC(F)Oc1ccc(cc1OC1CCOC1)C(=O)CC1CCCCC1
Show InChI InChI=1S/C19H24F2O4/c20-19(21)25-17-7-6-14(11-18(17)24-15-8-9-23-12-15)16(22)10-13-4-2-1-3-5-13/h6-7,11,13,15,19H,1-5,8-10,12H2
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n/an/a 661n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of full length human PDE4D2 expressed in Escherichia coli BL21 by liquid scintillation counting


J Med Chem 51: 7673-88 (2008)


Article DOI: 10.1021/jm701635j
BindingDB Entry DOI: 10.7270/Q2736QRN
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))
BDBM50273920
PNG
(1-[4-Methoxy-3-(tetrahydropyran-4-yloxy)phenyl]pen...)
Show SMILES CCCCC(=O)c1ccc(OC)c(OC2CCOCC2)c1
Show InChI InChI=1S/C17H24O4/c1-3-4-5-15(18)13-6-7-16(19-2)17(12-13)21-14-8-10-20-11-9-14/h6-7,12,14H,3-5,8-11H2,1-2H3
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n/an/a 724n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of full length human PDE4D2 expressed in Escherichia coli BL21 by liquid scintillation counting


J Med Chem 51: 7673-88 (2008)


Article DOI: 10.1021/jm701635j
BindingDB Entry DOI: 10.7270/Q2736QRN
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))
BDBM50273546
PNG
(1-(3,4-Bisdifluoromethoxyphenyl)-3-phenylpropan-1-...)
Show SMILES FC(F)Oc1ccc(cc1OC(F)F)C(=O)CCc1ccccc1
Show InChI InChI=1S/C17H14F4O3/c18-16(19)23-14-9-7-12(10-15(14)24-17(20)21)13(22)8-6-11-4-2-1-3-5-11/h1-5,7,9-10,16-17H,6,8H2
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n/an/a 820n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of full length human PDE4D2 expressed in Escherichia coli BL21 by liquid scintillation counting


J Med Chem 51: 7673-88 (2008)


Article DOI: 10.1021/jm701635j
BindingDB Entry DOI: 10.7270/Q2736QRN
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))
BDBM50273543
PNG
(CHEMBL457662 | Cyclohexyl-1-[4-difluoromethoxy-3-(...)
Show SMILES FC(F)Oc1ccc(cc1OC1CCOC1)C(=O)CCC1CCCCC1
Show InChI InChI=1S/C20H26F2O4/c21-20(22)26-18-9-7-15(12-19(18)25-16-10-11-24-13-16)17(23)8-6-14-4-2-1-3-5-14/h7,9,12,14,16,20H,1-6,8,10-11,13H2
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n/an/a 1.10E+3n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of full length human PDE4D2 expressed in Escherichia coli BL21 by liquid scintillation counting


J Med Chem 51: 7673-88 (2008)


Article DOI: 10.1021/jm701635j
BindingDB Entry DOI: 10.7270/Q2736QRN
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))
BDBM50273412
PNG
(3-Cyclohexyl-1-[4-methoxy-3-(tetrahydrofuran-3-ylo...)
Show SMILES COc1ccc(cc1OC1CCOC1)C(=O)CCC1CCCCC1
Show InChI InChI=1S/C20H28O4/c1-22-19-10-8-16(13-20(19)24-17-11-12-23-14-17)18(21)9-7-15-5-3-2-4-6-15/h8,10,13,15,17H,2-7,9,11-12,14H2,1H3
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n/an/a 1.91E+3n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of full length human PDE4D2 expressed in Escherichia coli BL21 by liquid scintillation counting


J Med Chem 51: 7673-88 (2008)


Article DOI: 10.1021/jm701635j
BindingDB Entry DOI: 10.7270/Q2736QRN
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))
BDBM50273573
PNG
(4-(2-Difluoromethoxy-5-pentanoylphenoxy)piperidine...)
Show SMILES CCCCC(=O)c1ccc(OC(F)F)c(OC2CCN(CC2)C(=O)OC(C)(C)C)c1
Show InChI InChI=1S/C22H31F2NO5/c1-5-6-7-17(26)15-8-9-18(29-20(23)24)19(14-15)28-16-10-12-25(13-11-16)21(27)30-22(2,3)4/h8-9,14,16,20H,5-7,10-13H2,1-4H3
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n/an/a 2.19E+3n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of full length human PDE4D2 expressed in Escherichia coli BL21 by liquid scintillation counting


J Med Chem 51: 7673-88 (2008)


Article DOI: 10.1021/jm701635j
BindingDB Entry DOI: 10.7270/Q2736QRN
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))
BDBM50273336
PNG
(1-[4-Methoxy-3-(tetrahydrofuran-3-yloxy)phenyl]-4-...)
Show SMILES COc1ccc(cc1OC1CCOC1)C(=O)CCCc1ccccc1
Show InChI InChI=1S/C21H24O4/c1-23-20-11-10-17(14-21(20)25-18-12-13-24-15-18)19(22)9-5-8-16-6-3-2-4-7-16/h2-4,6-7,10-11,14,18H,5,8-9,12-13,15H2,1H3
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n/an/a 2.29E+3n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of full length human PDE4D2 expressed in Escherichia coli BL21 by liquid scintillation counting


J Med Chem 51: 7673-88 (2008)


Article DOI: 10.1021/jm701635j
BindingDB Entry DOI: 10.7270/Q2736QRN
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))
BDBM50273508
PNG
(2-Cyclohexyl-1-[4-methoxy-3-(tetrahydrofuran-3-ylo...)
Show SMILES COc1ccc(cc1OC1CCOC1)C(=O)CC1CCCCC1
Show InChI InChI=1S/C19H26O4/c1-21-18-8-7-15(12-19(18)23-16-9-10-22-13-16)17(20)11-14-5-3-2-4-6-14/h7-8,12,14,16H,2-6,9-11,13H2,1H3
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n/an/a 2.57E+3n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of full length human PDE4D2 expressed in Escherichia coli BL21 by liquid scintillation counting


J Med Chem 51: 7673-88 (2008)


Article DOI: 10.1021/jm701635j
BindingDB Entry DOI: 10.7270/Q2736QRN
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))
BDBM50273507
PNG
(1-[4-Methoxy-3-(tetrahydrofuran-3-yloxy)phenyl]-3-...)
Show SMILES COc1ccc(cc1OC1CCOC1)C(=O)CCc1ccccc1
Show InChI InChI=1S/C20H22O4/c1-22-19-10-8-16(13-20(19)24-17-11-12-23-14-17)18(21)9-7-15-5-3-2-4-6-15/h2-6,8,10,13,17H,7,9,11-12,14H2,1H3
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n/an/a 2.57E+3n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of full length human PDE4D2 expressed in Escherichia coli BL21 by liquid scintillation counting


J Med Chem 51: 7673-88 (2008)


Article DOI: 10.1021/jm701635j
BindingDB Entry DOI: 10.7270/Q2736QRN
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))
BDBM50273333
PNG
(1-[4-Methoxy-3-(tetrahydropyran-4-yloxy)phenyl]but...)
Show SMILES CCCC(=O)c1ccc(OC)c(OC2CCOCC2)c1
Show InChI InChI=1S/C16H22O4/c1-3-4-14(17)12-5-6-15(18-2)16(11-12)20-13-7-9-19-10-8-13/h5-6,11,13H,3-4,7-10H2,1-2H3
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n/an/a 3.47E+3n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of full length human PDE4D2 expressed in Escherichia coli BL21 by liquid scintillation counting


J Med Chem 51: 7673-88 (2008)


Article DOI: 10.1021/jm701635j
BindingDB Entry DOI: 10.7270/Q2736QRN
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))
BDBM50273547
PNG
(1-(3,4-Bisdifluoromethoxyphenyl)-2-cyclohexylethan...)
Show SMILES FC(F)Oc1ccc(cc1OC(F)F)C(=O)CC1CCCCC1
Show InChI InChI=1S/C16H18F4O3/c17-15(18)22-13-7-6-11(9-14(13)23-16(19)20)12(21)8-10-4-2-1-3-5-10/h6-7,9-10,15-16H,1-5,8H2
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n/an/a 5.20E+3n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of full length human PDE4D2 expressed in Escherichia coli BL21 by liquid scintillation counting


J Med Chem 51: 7673-88 (2008)


Article DOI: 10.1021/jm701635j
BindingDB Entry DOI: 10.7270/Q2736QRN
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))
BDBM50273983
PNG
(1-[3-Methoxy-4-(pyridin-2-yloxy)phenyl]-1-quinolin...)
Show SMILES CCCC(O)(c1ccc(Oc2ccccn2)c(OC)c1)c1cnc2ccccc2c1
Show InChI InChI=1S/C25H24N2O3/c1-3-13-25(28,20-15-18-8-4-5-9-21(18)27-17-20)19-11-12-22(23(16-19)29-2)30-24-10-6-7-14-26-24/h4-12,14-17,28H,3,13H2,1-2H3
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n/an/a 6.00E+3n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of full length human PDE4D2 expressed in Escherichia coli BL21 by liquid scintillation counting


J Med Chem 51: 7673-88 (2008)


Article DOI: 10.1021/jm701635j
BindingDB Entry DOI: 10.7270/Q2736QRN
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))
BDBM50273601
PNG
(4-[3-Methoxy-4-(pyridin-2-yloxy)phenyl]-4-quinolin...)
Show SMILES COc1cc(ccc1Oc1ccccn1)C(CC(C)=O)c1cnc2ccccc2c1
Show InChI InChI=1S/C25H22N2O3/c1-17(28)13-21(20-14-19-7-3-4-8-22(19)27-16-20)18-10-11-23(24(15-18)29-2)30-25-9-5-6-12-26-25/h3-12,14-16,21H,13H2,1-2H3
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n/an/a 6.03E+3n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of full length human PDE4D2 expressed in Escherichia coli BL21 by liquid scintillation counting


J Med Chem 51: 7673-88 (2008)


Article DOI: 10.1021/jm701635j
BindingDB Entry DOI: 10.7270/Q2736QRN
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))
BDBM50273603
PNG
(2-(2-methoxy-4-(1-(pyridin-3-yl)pentyl)phenoxy)pyr...)
Show SMILES CCCCC(c1cccnc1)c1ccc(Oc2ccccn2)c(OC)c1
Show InChI InChI=1S/C22H24N2O2/c1-3-4-9-19(18-8-7-13-23-16-18)17-11-12-20(21(15-17)25-2)26-22-10-5-6-14-24-22/h5-8,10-16,19H,3-4,9H2,1-2H3
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n/an/a 1.00E+4n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of full length human PDE4D2 expressed in Escherichia coli BL21 by liquid scintillation counting


J Med Chem 51: 7673-88 (2008)


Article DOI: 10.1021/jm701635j
BindingDB Entry DOI: 10.7270/Q2736QRN
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))
BDBM50273925
PNG
(1-[4-Methoxy-3-(tetrahydrofuran-3-yloxy)phenyl]pen...)
Show SMILES CCCCC(O)c1ccc(OC)c(OC2CCOC2)c1
Show InChI InChI=1S/C16H24O4/c1-3-4-5-14(17)12-6-7-15(18-2)16(10-12)20-13-8-9-19-11-13/h6-7,10,13-14,17H,3-5,8-9,11H2,1-2H3
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n/an/a 1.00E+4n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of full length human PDE4D2 expressed in Escherichia coli BL21 by liquid scintillation counting


J Med Chem 51: 7673-88 (2008)


Article DOI: 10.1021/jm701635j
BindingDB Entry DOI: 10.7270/Q2736QRN
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))
BDBM50273988
PNG
(1-[3-Methoxy-4-(tetrahydrofuran-3-yloxy)phenyl]but...)
Show SMILES CCCC(=O)c1ccc(OC2CCOC2)c(OC)c1
Show InChI InChI=1S/C15H20O4/c1-3-4-13(16)11-5-6-14(15(9-11)17-2)19-12-7-8-18-10-12/h5-6,9,12H,3-4,7-8,10H2,1-2H3
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n/an/a 2.40E+4n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of full length human PDE4D2 expressed in Escherichia coli BL21 by liquid scintillation counting


J Med Chem 51: 7673-88 (2008)


Article DOI: 10.1021/jm701635j
BindingDB Entry DOI: 10.7270/Q2736QRN
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))
BDBM50273986
PNG
(4-(4-Butyryl-2-methoxyphenoxy)piperidine-1-carboxy...)
Show SMILES CCCC(=O)c1ccc(OC2CCN(CC2)C(=O)OC(C)(C)C)c(OC)c1
Show InChI InChI=1S/C21H31NO5/c1-6-7-17(23)15-8-9-18(19(14-15)25-5)26-16-10-12-22(13-11-16)20(24)27-21(2,3)4/h8-9,14,16H,6-7,10-13H2,1-5H3
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n/an/a 2.88E+4n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of full length human PDE4D2 expressed in Escherichia coli BL21 by liquid scintillation counting


J Med Chem 51: 7673-88 (2008)


Article DOI: 10.1021/jm701635j
BindingDB Entry DOI: 10.7270/Q2736QRN
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))
BDBM50273510
PNG
(1-[4-Difluoromethoxy-3-(pyridin-2-yloxy)phenyl]but...)
Show SMILES CCCC(=O)c1ccc(OC(F)F)c(Oc2ccccn2)c1
Show InChI InChI=1S/C16H15F2NO3/c1-2-5-12(20)11-7-8-13(22-16(17)18)14(10-11)21-15-6-3-4-9-19-15/h3-4,6-10,16H,2,5H2,1H3
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n/an/a 3.98E+4n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of full length human PDE4D2 expressed in Escherichia coli BL21 by liquid scintillation counting


J Med Chem 51: 7673-88 (2008)


Article DOI: 10.1021/jm701635j
BindingDB Entry DOI: 10.7270/Q2736QRN
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))
BDBM50273548
PNG
(1-(3,4-Bisdifluoromethoxyphenyl)-4-phenylbutan-1-o...)
Show SMILES FC(F)Oc1ccc(cc1OC(F)F)C(=O)CCCc1ccccc1
Show InChI InChI=1S/C18H16F4O3/c19-17(20)24-15-10-9-13(11-16(15)25-18(21)22)14(23)8-4-7-12-5-2-1-3-6-12/h1-3,5-6,9-11,17-18H,4,7-8H2
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n/an/a 4.37E+4n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of full length human PDE4D2 expressed in Escherichia coli BL21 by liquid scintillation counting


J Med Chem 51: 7673-88 (2008)


Article DOI: 10.1021/jm701635j
BindingDB Entry DOI: 10.7270/Q2736QRN
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))
BDBM50273332
PNG
(4-Methoxy-3-(tetrahydropyran-4-yloxyphenyl]quinoli...)
Show SMILES COc1ccc(cc1OC1CCOCC1)C(=O)c1cnc2ccccc2c1
Show InChI InChI=1S/C22H21NO4/c1-25-20-7-6-16(13-21(20)27-18-8-10-26-11-9-18)22(24)17-12-15-4-2-3-5-19(15)23-14-17/h2-7,12-14,18H,8-11H2,1H3
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n/an/a 4.47E+4n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of full length human PDE4D2 expressed in Escherichia coli BL21 by liquid scintillation counting


J Med Chem 51: 7673-88 (2008)


Article DOI: 10.1021/jm701635j
BindingDB Entry DOI: 10.7270/Q2736QRN
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))
BDBM50273985
PNG
(1-[3-Methoxy-4-(tetrahydropyran-4-yloxy)phenyl]but...)
Show SMILES CCCC(=O)c1ccc(OC2CCOCC2)c(OC)c1
Show InChI InChI=1S/C16H22O4/c1-3-4-14(17)12-5-6-15(16(11-12)18-2)20-13-7-9-19-10-8-13/h5-6,11,13H,3-4,7-10H2,1-2H3
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n/an/a 6.03E+4n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of full length human PDE4D2 expressed in Escherichia coli BL21 by liquid scintillation counting


J Med Chem 51: 7673-88 (2008)


Article DOI: 10.1021/jm701635j
BindingDB Entry DOI: 10.7270/Q2736QRN
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))
BDBM50273987
PNG
(1-[3-Methoxy-4-(tetrahydropyran-4-yloxy)phenyl]pen...)
Show SMILES CCCCC(=O)c1ccc(OC2CCOCC2)c(OC)c1
Show InChI InChI=1S/C17H24O4/c1-3-4-5-15(18)13-6-7-16(17(12-13)19-2)21-14-8-10-20-11-9-14/h6-7,12,14H,3-5,8-11H2,1-2H3
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n/an/a 7.08E+4n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of full length human PDE4D2 expressed in Escherichia coli BL21 by liquid scintillation counting


J Med Chem 51: 7673-88 (2008)


Article DOI: 10.1021/jm701635j
BindingDB Entry DOI: 10.7270/Q2736QRN
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))
BDBM50273602
PNG
(4-(4-Hydroxy-3-methoxyphenyl]-4-pyridin-3-ylbutan-...)
Show SMILES COc1cc(ccc1O)C(CC(C)=O)c1cccnc1
Show InChI InChI=1S/C16H17NO3/c1-11(18)8-14(13-4-3-7-17-10-13)12-5-6-15(19)16(9-12)20-2/h3-7,9-10,14,19H,8H2,1-2H3
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n/an/a 7.94E+4n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of full length human PDE4D2 expressed in Escherichia coli BL21 by liquid scintillation counting


J Med Chem 51: 7673-88 (2008)


Article DOI: 10.1021/jm701635j
BindingDB Entry DOI: 10.7270/Q2736QRN
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))
BDBM50273984
PNG
(4-(2-Methoxy-4-pentanoylphenoxy)piperidine-1-carbo...)
Show SMILES CCCCC(=O)c1ccc(OC2CCN(CC2)C(=O)OC(C)(C)C)c(OC)c1
Show InChI InChI=1S/C22H33NO5/c1-6-7-8-18(24)16-9-10-19(20(15-16)26-5)27-17-11-13-23(14-12-17)21(25)28-22(2,3)4/h9-10,15,17H,6-8,11-14H2,1-5H3
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n/an/a 9.33E+4n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of full length human PDE4D2 expressed in Escherichia coli BL21 by liquid scintillation counting


J Med Chem 51: 7673-88 (2008)


Article DOI: 10.1021/jm701635j
BindingDB Entry DOI: 10.7270/Q2736QRN
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))
BDBM50273331
PNG
(1-[3-Methoxy-4-(tetrahydrofuran-3-yloxy)phenyl]pen...)
Show SMILES CCCCC(=O)c1ccc(OC2CCOC2)c(OC)c1
Show InChI InChI=1S/C16H22O4/c1-3-4-5-14(17)12-6-7-15(16(10-12)18-2)20-13-8-9-19-11-13/h6-7,10,13H,3-5,8-9,11H2,1-2H3
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n/an/a 1.00E+5n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of full length human PDE4D2 expressed in Escherichia coli BL21 by liquid scintillation counting


J Med Chem 51: 7673-88 (2008)


Article DOI: 10.1021/jm701635j
BindingDB Entry DOI: 10.7270/Q2736QRN
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))
BDBM50273509
PNG
(1-[4-Methoxy-3-(piperidin-4-yloxy)phenyl]pentan-1-...)
Show SMILES CCCCC(=O)c1ccc(OC)c(OC2CCNCC2)c1
Show InChI InChI=1S/C17H25NO3/c1-3-4-5-15(19)13-6-7-16(20-2)17(12-13)21-14-8-10-18-11-9-14/h6-7,12,14,18H,3-5,8-11H2,1-2H3
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n/an/a 1.02E+5n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of full length human PDE4D2 expressed in Escherichia coli BL21 by liquid scintillation counting


J Med Chem 51: 7673-88 (2008)


Article DOI: 10.1021/jm701635j
BindingDB Entry DOI: 10.7270/Q2736QRN
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))
BDBM50273924
PNG
(1-[3-Methoxy-4-(tetrahydrofuran-3-yloxy)phenyl]pen...)
Show SMILES CCCCC(O)c1ccc(OC2CCOC2)c(OC)c1
Show InChI InChI=1S/C16H24O4/c1-3-4-5-14(17)12-6-7-15(16(10-12)18-2)20-13-8-9-19-11-13/h6-7,10,13-14,17H,3-5,8-9,11H2,1-2H3
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n/an/a 3.98E+5n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of full length human PDE4D2 expressed in Escherichia coli BL21 by liquid scintillation counting


J Med Chem 51: 7673-88 (2008)


Article DOI: 10.1021/jm701635j
BindingDB Entry DOI: 10.7270/Q2736QRN
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))
BDBM50273923
PNG
(1-[3-Methoxy-4-(tetrahydrofuran-3-yloxy)phenyl]but...)
Show SMILES CCCC(O)c1ccc(OC2CCOC2)c(OC)c1
Show InChI InChI=1S/C15H22O4/c1-3-4-13(16)11-5-6-14(15(9-11)17-2)19-12-7-8-18-10-12/h5-6,9,12-13,16H,3-4,7-8,10H2,1-2H3
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n/an/a 5.25E+5n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of full length human PDE4D2 expressed in Escherichia coli BL21 by liquid scintillation counting


J Med Chem 51: 7673-88 (2008)


Article DOI: 10.1021/jm701635j
BindingDB Entry DOI: 10.7270/Q2736QRN
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))
BDBM50273922
PNG
(1-[3-Methoxy-4-(tetrahydropyran-4-yloxy)phenyl]pen...)
Show SMILES CCCCC(O)c1ccc(OC2CCOCC2)c(OC)c1
Show InChI InChI=1S/C17H26O4/c1-3-4-5-15(18)13-6-7-16(17(12-13)19-2)21-14-8-10-20-11-9-14/h6-7,12,14-15,18H,3-5,8-11H2,1-2H3
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Article
PubMed
n/an/a 5.37E+5n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of full length human PDE4D2 expressed in Escherichia coli BL21 by liquid scintillation counting


J Med Chem 51: 7673-88 (2008)


Article DOI: 10.1021/jm701635j
BindingDB Entry DOI: 10.7270/Q2736QRN
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))
BDBM50273921
PNG
(1-[3-Methoxy-4-(tetrahydropyran-4-yloxy)phenyl]but...)
Show SMILES CCCC(O)c1ccc(OC2CCOCC2)c(OC)c1
Show InChI InChI=1S/C16H24O4/c1-3-4-14(17)12-5-6-15(16(11-12)18-2)20-13-7-9-19-10-8-13/h5-6,11,13-14,17H,3-4,7-10H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.51E+6n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of full length human PDE4D2 expressed in Escherichia coli BL21 by liquid scintillation counting


J Med Chem 51: 7673-88 (2008)


Article DOI: 10.1021/jm701635j
BindingDB Entry DOI: 10.7270/Q2736QRN
More data for this
Ligand-Target Pair