Found 7 hits of ic50 data for polymerid = 50006881 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Equilibrative nucleoside transporter 2
(Homo sapiens (Human)) | BDBM56941
(6-[[4-(4-fluorophenyl)-1-piperazinyl]methyl]-N2-(3...)Show SMILES Cc1cccc(Nc2nc(N)nc(CN3CCN(CC3)c3ccc(F)cc3)n2)c1 Show InChI InChI=1S/C21H24FN7/c1-15-3-2-4-17(13-15)24-21-26-19(25-20(23)27-21)14-28-9-11-29(12-10-28)18-7-5-16(22)6-8-18/h2-8,13H,9-12,14H2,1H3,(H3,23,24,25,26,27) | UniProtKB/SwissProt
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AffyNet 
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PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 570 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2022.114645
BindingDB Entry DOI: 10.7270/Q2SQ94GB |
More data for this
Ligand-Target Pair | |
Equilibrative nucleoside transporter 2
(Homo sapiens (Human)) | BDBM50606918
(CHEMBL5219061)Show SMILES Nc1nc(CN2CCN(CC2)c2ccccc2F)nc(Nc2cccc3ccccc23)n1 | UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.69E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2022.114645
BindingDB Entry DOI: 10.7270/Q2SQ94GB |
More data for this
Ligand-Target Pair | |
Equilibrative nucleoside transporter 2
(Homo sapiens (Human)) | BDBM50606918
(CHEMBL5219061)Show SMILES Nc1nc(CN2CCN(CC2)c2ccccc2F)nc(Nc2cccc3ccccc23)n1 | UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.36E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2022.114645
BindingDB Entry DOI: 10.7270/Q2SQ94GB |
More data for this
Ligand-Target Pair | |
Equilibrative nucleoside transporter 2
(Homo sapiens (Human)) | BDBM50606919
(CHEMBL5219347)Show SMILES COc1ccc(Nc2nc(N)nc(CN3CCN(CC3)c3ccccc3F)n2)cc1 | UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 7.71E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2022.114645
BindingDB Entry DOI: 10.7270/Q2SQ94GB |
More data for this
Ligand-Target Pair | |
Equilibrative nucleoside transporter 2
(Homo sapiens (Human)) | BDBM14487
((2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxy...)Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O Show InChI InChI=1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1 | UniProtKB/SwissProt
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CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.06E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences, Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to recombinant human ENT2 expressed in Saccharomyces cerevisiae assessed as inhibition of [3H]-uridine transport after 15 mins by sc... |
Drug Metab Dispos 41: 916-22 (2013)
Article DOI: 10.1124/dmd.112.049858
BindingDB Entry DOI: 10.7270/Q21N82VJ |
More data for this
Ligand-Target Pair | |
Equilibrative nucleoside transporter 2
(Homo sapiens (Human)) | BDBM50138530
((2R,3R,5R)-2-Hydroxymethyl-5-{6-[(R)-(tetrahydro-f...)Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N[C@@H]3CCOC3)ncnc12 Show InChI InChI=1S/C14H19N5O5/c20-3-8-10(21)11(22)14(24-8)19-6-17-9-12(15-5-16-13(9)19)18-7-1-2-23-4-7/h5-8,10-11,14,20-22H,1-4H2,(H,15,16,18)/t7?,8-,10-,11-,14?/m1/s1 | UniProtKB/SwissProt
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CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.90E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences, Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to recombinant human ENT2 expressed in Saccharomyces cerevisiae assessed as inhibition of [3H]-uridine transport after 15 mins by sc... |
Drug Metab Dispos 41: 916-22 (2013)
Article DOI: 10.1124/dmd.112.049858
BindingDB Entry DOI: 10.7270/Q21N82VJ |
More data for this
Ligand-Target Pair | |
Equilibrative nucleoside transporter 2
(Homo sapiens (Human)) | BDBM50088517
(CHEBI:16704 | Uridine)Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ccc(=O)[nH]c1=O |r| Show InChI InChI=1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1 | UniProtKB/SwissProt
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MCE
KEGG
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.34E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences, Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to recombinant human ENT2 expressed in Saccharomyces cerevisiae assessed as inhibition of [3H]-uridine transport after 15 mins by sc... |
Drug Metab Dispos 41: 916-22 (2013)
Article DOI: 10.1124/dmd.112.049858
BindingDB Entry DOI: 10.7270/Q21N82VJ |
More data for this
Ligand-Target Pair | |
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